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<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z4F5</accession>
    <name>A0A3S0Z4F5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_023073</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001800">
        <property type="protein sequence ID" value="RUS69165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z4F5"/>
    <dbReference type="STRING" id="188477.A0A3S0Z4F5"/>
    <dbReference type="OrthoDB" id="420380at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000054">
        <property type="entry name" value="Prolyl 4-hydroxylase subunit alpha-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF180">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0847">Vitamin C</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="9">
        <location>
            <begin position="542"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="308"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="361"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="378"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS69165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="702" mass="78773" checksum="1EAEEF80D6F047D2" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z685</accession>
    <name>A0A3S0Z685_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carboxypeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_022009</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001457">
        <property type="protein sequence ID" value="RUS70229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z685"/>
    <dbReference type="STRING" id="188477.A0A3S0Z685"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF472">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CPVL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS70229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="456" mass="51152" checksum="53A245269EB94A49" modified="2019-04-10" version="1" fragment="single">PLHLSPYIARGEIGKARSLSKVKDPCRAQRGRVCDVTIPESFSGFITVDNTLGKHMFFWFFPSQVKPDAPVSIWLNGGPGVTSMSGLFWENGPLQPRRRKVMDAFIPEEFDIRNSSWSDALSMLYIDNPVGAGYSYQERGNPEDLPTQASYTEDLYQFVEQFYQLFPDLFAKELYIGGQSYAAKYVTSLAYRVHQAVKGGQTRLHLAGIYLGSPFFAPEVIIPAQAEFLYSMGAMTRTQANRHRASMMATIRRYTAPNKGLTGQQTRGTPSTSAILEELFFKGLPSNDNYVSVQAVVPYAVIHRIMTSGRIRRAVHAGNLTFHAINYDLHDRMGQDYLLSTSDKLGALLDSGQYKVLIFNGDLDPVTSSGAVEDAVLQIPWMGMSDYASEPRRVWKWPATPENLEVSSLFGFFTKSRDLCRVVVHRAGHQVPHDQLAISRQMMEQFVNVGCVFTWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z6K4</accession>
    <name>A0A3S0Z6K4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Receptor ligand binding region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_020441</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001157">
        <property type="protein sequence ID" value="RUS71805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z6K4"/>
    <dbReference type="STRING" id="188477.A0A3S0Z6K4"/>
    <dbReference type="OrthoDB" id="425344at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Receptor ligand binding region" evidence="7">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS71805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="134" mass="14708" checksum="C7098CB5342357F0" modified="2019-04-10" version="1" fragment="single">MIYAVDRVNADPTILPNIRLGGLGIDDCSSPILGQAFLAQLQRGNLNVMDSAGNVLDPRTIEAYTAAYSSPLTIPLAGAMNELKRPMVGYRARGSELDDSVMYPYYISAVPSLQEEIKAIVLMLKKLDWMFVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z6N4</accession>
    <name>A0A3S0Z6N4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_021698</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001385">
        <property type="protein sequence ID" value="RUS70540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z6N4"/>
    <dbReference type="STRING" id="188477.A0A3S0Z6N4"/>
    <dbReference type="OrthoDB" id="10019906at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS70540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="164" mass="18790" checksum="72A7C688DCA976E5" modified="2019-04-10" version="1">MNQKMRPEAEFLRLYDPPTECGDGRCVDLFPEFLYCVVVPCGVLVLVCLLIAIVACCKSKACAMELEDYNSVRRASLTLRQMSRNRETPMMGSRTNSMTLDRTQRRHNRNRDSCSSAPGTLQRQNRNRRAERTTSSMAMQFPYADETDNSVNGFSSHLQAWIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z6S3</accession>
    <name>A0A3S0Z6S3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PLA2c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_021610</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001365">
        <property type="protein sequence ID" value="RUS70626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z6S3"/>
    <dbReference type="STRING" id="188477.A0A3S0Z6S3"/>
    <dbReference type="OrthoDB" id="419768at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047498">
        <property type="term" value="F:calcium-dependent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF40">
        <property type="entry name" value="PATATIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2 3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLA2c" evidence="5">
        <location>
            <begin position="52"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="642"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="690"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="777"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="651"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="703"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="741"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="782"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="822"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="834"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="859"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="909"/>
            <end position="933"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS70626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="957" mass="107987" checksum="E9AD59F420718C20" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z823</accession>
    <name>A0A3S0Z823_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_020742</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001204">
        <property type="protein sequence ID" value="RUS71491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z823"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="405"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS71491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="437" mass="49225" checksum="A126C9D00D9F4C8D" modified="2019-04-10" version="1">MLEASLPTPKSKSKKRDDSDQNSVDSYESIDDEKRAKRLKRESKSSSSADSRKSSDKSNASRRKKRSDVRLSETEEDERDSPSPKNSEAMNQKRGRDDDRHSGSKTERVKGILKKQRDQHDVNVDDRMKIKSKKADYTDEYPHSDSNHATENHDVDMLYTQFQKRLVMGGTVFLAMISFVLAIYPFETYRTGYSKSDVCLFRDSACIVDISASVVFFVSGLINIATLIANREKWWVTTRHPSPFTWINIVILVKSIGISASFFGGATELMDVLLGGAFFALAMILPIVARTNKSVAIAIFLSILYGGFIFAVIINDAVEFTKNHYGDGIEMGFILTMGLFVPGAAMTLPLTVRAFECVMIDGRNHHKDIDDHSTQMTIKKMKGDEHDTLEADHVHKRLKMFKSPAVLEIIYMGCQLALMTSIYSQLVVFWIDANVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z8J4</accession>
    <name>A0A3S0Z8J4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_022956</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001746">
        <property type="protein sequence ID" value="RUS69282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z8J4"/>
    <dbReference type="STRING" id="188477.A0A3S0Z8J4"/>
    <dbReference type="OrthoDB" id="10593998at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS69282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="119" mass="13499" checksum="591FE5B1E56A2AAD" modified="2019-04-10" version="1" fragment="single">LYLTICTLYSAMCTLYSPRCTQYSPICTHNSHICTLYSPMCTLYSPKCTHYSPFCTLNTPNCTVYSPIYRLYSPICTLYSPNCTIYSPICTLYSPNCTLYSPICTLYSPNCTLHSPNQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z9Y6</accession>
    <name>A0A3S0Z9Y6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_019313</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001000">
        <property type="protein sequence ID" value="RUS72917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z9Y6"/>
    <dbReference type="STRING" id="188477.A0A3S0Z9Y6"/>
    <dbReference type="OrthoDB" id="19132at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="45"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="580"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="580"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS72917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="606" mass="68556" checksum="70E4A20FC86E62D8" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZBQ1</accession>
    <name>A0A3S0ZBQ1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_020947</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001238">
        <property type="protein sequence ID" value="RUS71290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZBQ1"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630:SF6">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS71290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="37995" checksum="9EB9BD73B3FE8557" modified="2019-04-10" version="1">MFTAKNREELETKGVTMVPDVLSMEDCDKHQAFFRNWLKRFPDGQWPETLSSLIQGYGAGHLEPAWDVRLKTRSVFAQVWGTNKLLSSMDFIAIGRPPEDGEEKFWAEGDNWLHTGQSADRVSLHAYQGAVYLEGCDEDDWTFEVFEGSHTHFDEFMDTTDQWRCDKIAGDHLDWFKSRGCRRRRVPCPKGGMILWDSRLVHANARPKAGRANTGRWRYVVFVCMTPAVWATPGDLAVKRRAYEQRRLTAHWPSDGVKLANNCPLPDQSLDPVDLLDLPEVARTDDAKRLVGILPYDEADPDWLDETDENRCKFRPAWNKERWAKHLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZC74</accession>
    <name>A0A3S0ZC74_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_016699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000732">
        <property type="protein sequence ID" value="RUS75531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZC74"/>
    <dbReference type="OrthoDB" id="19473at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16189:SF6">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16189">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 104-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS75531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="495" mass="53902" checksum="AD3759DEF6D0CB06" modified="2019-04-10" version="1">MKGRMQHIREIPLVQPPNLHLMGRLFLGCGVRQCFDAMLLVQFIALLICYALAGSEAFAELLGINYYYIIPVFVTVLTSAIVFALQLIQPVVSVLTFLKGSLLLGTTIVTFYVGMAVAEEISNDFTQIGGPFLMGTVALGGVVNTMPYTFEKVPYKKRQIRKYRLAVQLGLWTCVLLNIMWCWAVLDIVPQTIEMACLSKEYLSSLRPNVSGAGVATITCEGDLSLERAADKGEISTLPLTKLLQRDHPRFTWVAVLVEVFIMVSITVSYLTIGSALHHTLKGMVASQMQNKKRNNRIKHSKNSAGRWFASTCVSLGAFTLVFAVAMLNPQGFVIILEKLVSFAINIEVGLFISLMIVISRRSKYRDLEVPLPLSRCALYLAVLLPLFFNFAVFFDVYSSVLILVSPNEHPSLVMNLTTQGLNATGTSVVSGFKELLMTTASSNATASTIKSSAAPATSATMISAVIESLSGSNLVAGLNASSLGNSTFLPGPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZEZ5</accession>
    <name>A0A3S0ZEZ5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_016174</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000689">
        <property type="protein sequence ID" value="RUS76070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZEZ5"/>
    <dbReference type="STRING" id="188477.A0A3S0ZEZ5"/>
    <dbReference type="OrthoDB" id="6157630at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF36">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS76070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="297" mass="34404" checksum="CC8D0C51F0E89B33" modified="2019-04-10" version="1" fragment="single">MGFWSQLGLLLWKNWILQKRRVCVTIFEIILPVFFAVLILLIRTLVNKREISTPTTYSQSSVAIRSDYFEPTTIVGYVPDTTETSIIMQSVLAMLENRTVYTSSVNFTKMGFQTEELALDFISSNSLEMKHMVVFNGVEASSNSIPKNIEVSIRPYSGSDQWRTEYTFPFFQTNEPRRDDYPEYRRSGFNFLQALVGEALAKYWVQKDGGNPDSIYFGAYIQRMPYPPYFDDPMIQVLQGNLPLFLILSFILSVIINTKNLVYEKERKLKESMKLMGLQASVHWVSWFLTFAIYLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZFK0</accession>
    <name>A0A3S0ZFK0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfatase-modifying factor enzyme-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_015797</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase-modifying factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000661">
        <property type="protein sequence ID" value="RUS76456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZFK0"/>
    <dbReference type="STRING" id="188477.A0A3S0ZFK0"/>
    <dbReference type="OrthoDB" id="659at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120147">
        <property type="term" value="F:formylglycine-generating oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="entry name" value="paralog of FGE (formylglycine-generating enzyme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051043">
        <property type="entry name" value="Sulfatase_Mod_Factor_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23150:SF19">
        <property type="entry name" value="FORMYLGLYCINE-GENERATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23150">
        <property type="entry name" value="SULFATASE MODIFYING FACTOR 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="3">
        <location>
            <begin position="2"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS76456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="124" mass="13900" checksum="7AE0E5CB46417A9D" modified="2019-04-10" version="1">MNIWQGEFPSSNTEEDGYGTTAPVTAFPKQNKFGLKNIVGNVWEWTQDWWTTEHSAEPKINPTGPPTGVDKVKKGGSFQCHKSYCYRYRCAARSQNTPDSSASNLGFRCASSKLPDYLKSKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZIL7</accession>
    <name>A0A3S0ZIL7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_012462</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mTERF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000428">
        <property type="protein sequence ID" value="RUS79778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZIL7"/>
    <dbReference type="OrthoDB" id="75923at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006393">
        <property type="term" value="P:termination of mitochondrial transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.70.10">
        <property type="entry name" value="Transcription termination factor 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003690">
        <property type="entry name" value="MTERF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038538">
        <property type="entry name" value="MTERF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15437">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15437:SF6">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02536">
        <property type="entry name" value="mTERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS79778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="351" mass="40730" checksum="099129827863677C" modified="2019-04-10" version="1">MLKSCFLARQAALNMLGPVTLQQGLHSFSFLHRFWMRNSLLSFPSARQFHQRHKVKQVSIPFKNWAQTLLKTLHSETKYTQGYPQSFWQRHYSESVKSTSEDSSNLYSLSVDSLLSEAHIRRLAVKLSCKVAEVKSLVKGYAFLIHMDFHLLEGKVNLLLSYNLPVSFVREHLRIVYQASEKVLEERLELLKDSGLLHSHHLEIDKLAHLLECNGTEFAKSFKYRCDQRDALEGCYDQLAYLQMRLACSKEKAQSLLGSYPLERHVSNVKLKRLLDFFLVEVERSPDFVISYRKLLTFSVSRLQNRWRVMQAAGIESEAEMVYVWCMSQKEFEKQYSEHLKSSNSSSSSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZLX4</accession>
    <name>A0A3S0ZLX4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_021795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001408">
        <property type="protein sequence ID" value="RUS70446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZLX4"/>
    <dbReference type="STRING" id="188477.A0A3S0ZLX4"/>
    <dbReference type="OrthoDB" id="428346at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS70446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="329" mass="37501" checksum="F4FCC71E8549C3B1" modified="2019-04-10" version="1">MRTNHVIWHETLKNHNYDSMIPAWGRIHTSLLMGEGWVRLMKPTALLRTSLNKALIHIAEQIQEEAEVYKTLQNYSSCCKKRGHPTTVPVCAGNQTYCGKEKNPQICCDKLKMKMFPGCPELRDPCASLDSRACSTRLSKTFPNRWDNTRVQMLAHNFCTMPPSVSKLSGTIESLRNKKGFDMTDMNLMCAHIRLGQSKTFPFENFQFNHEADIKGLWGFLRSYAQKGYHIYLAADSQEAKDEAKGIFGDRLHVMEEKIVHIDHERNGKAEDAKAGLLFTLTEQLLLTTACQEIVRSHSGFSLRAVEIRKKLNGGDRGRVYRFQGGYVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZRE5</accession>
    <name>A0A3S0ZRE5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">EGW08_018705</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">EC2010</strain>
            <tissue evidence="19">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000927">
        <property type="protein sequence ID" value="RUS73520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZRE5"/>
    <dbReference type="STRING" id="188477.A0A3S0ZRE5"/>
    <dbReference type="OrthoDB" id="6151331at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0229">DNA integration</keyword>
    <keyword evidence="15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="14" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="18">
        <location>
            <begin position="469"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="721"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RUS73520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="929" mass="105370" checksum="76CA3AFFB99A673C" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZSG8</accession>
    <name>A0A3S0ZSG8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_010603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000326">
        <property type="protein sequence ID" value="RUS81640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZSG8"/>
    <dbReference type="STRING" id="188477.A0A3S0ZSG8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS81640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="458" mass="50045" checksum="E032BEB5D02D75EC" modified="2019-04-10" version="1">MEECDVSLVSHRFSVRHGNARINAVTTTSADSGSTVIIPETEPSFTTFEGRYRKAKHVCDDIVNFLSVVGMVEFTEKIHHLEHLLQLWCSPVDENESLMATNRTAARVVTLDPPLSPECTTGTATAAVTNTAIIPVTEQGVSPECFASTASSTVTNTATIPVTEQSVSPECFASTASSTVTNTALIPASMQGVSPECTVGTASTKVTNTAFIQLQCKVFHLSAQQAQTLPLSQLQCKVFHLSAQQALPQPQSQTLPSPQLQCKVFHLSAQQAQTLPLSQLQCKMFQLSVLQALQPPQSQTLPLSQITAVTVVTLDPPLGPNTVITLDVPPECSPYAESWPKMDKIPKHRGRPCTKQNFTQRKIALKRKRTCPKKFADLTEEAKIFLIIRATCTYTDTSTVITESCLKPVADFGDLVMDDRVDIEMVRPFFDTRAFSKLQYGVLNRKRDGPFSCGKCHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZTY8</accession>
    <name>A0A3S0ZTY8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_006489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDK5RAP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000160">
        <property type="protein sequence ID" value="RUS85775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZTY8"/>
    <dbReference type="STRING" id="188477.A0A3S0ZTY8"/>
    <dbReference type="OrthoDB" id="340432at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008491">
        <property type="entry name" value="CDK5RAP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14894">
        <property type="entry name" value="CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14894:SF0">
        <property type="entry name" value="CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05600">
        <property type="entry name" value="CDK5RAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS85775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="101" mass="11842" checksum="14023F234D5FB2E7" modified="2019-04-10" version="1" fragment="single">MTQQALQNLPIDIHYNKLLDWLVNRRHCTQQCQTILTVIRDKILKAKEASQKEDHPNQQILELLSIPQLNYFQVKQLFEHLKSTDAGKKNLIGQFSNQSMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZUD8</accession>
    <name>A0A3S0ZUD8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_006167</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000151">
        <property type="protein sequence ID" value="RUS86074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZUD8"/>
    <dbReference type="OrthoDB" id="6096173at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018633663" evidence="2">
        <location>
            <begin position="29"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS86074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="312" mass="35566" checksum="82B2E35B1528953F" modified="2019-04-10" version="1">MQTCAAKRQRHTPLVLCILLTFTFTSMGSKIPEISPQTPDLNGIRPLIGRTSVAFQEQASAWSLFKSKVTSSQTGSMPRSERSEVTAHKVRVKRQTAGTFFGLTSRQCGFVPLNNASFVESIYQYFSEESSTNILEYDVKIVSAGQEFDLTKASSLEAYKPFRWYRTQGEGSSQLLQVNHYYFGLIWPFMDLGLDKVTVTLNVTSPACLQNLPRGEIELLLTDYFLRDFDVNPSTVERPYVKAETVEVCHMTIRNENDWGKLTYKCCGFESDILQCRDVIEDAWVWVLRAFIMTVTVLLFLYFPAILPRGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZVC9</accession>
    <name>A0A3S0ZVC9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="5">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EGW08_016092</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">EC2010</strain>
            <tissue evidence="15">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="5"/>
    <dbReference type="EMBL" id="RQTK01000684">
        <property type="protein sequence ID" value="RUS76149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZVC9"/>
    <dbReference type="STRING" id="188477.A0A3S0ZVC9"/>
    <dbReference type="OrthoDB" id="1164111at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000048">
        <property type="entry name" value="CCR4-associated factor 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039637">
        <property type="entry name" value="CNOT7/CNOT8/Pop2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10797">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RUS76149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="289" mass="33153" checksum="221E6BD63C8C506A" modified="2019-04-10" version="1">MPSVIDDHGIRDVWASNMEEELRNISHVVKTHRYIAMDTEFPGVVARPIGDFRSTQEYTYHQMKCNVNLLKIIQIGFTFFDEDGNRAKPVSTWQFNFKFCLDDDMYAQESIELLRKSGIQFERHERDGMDPFDFAAELIGAGVVLQPNVFLSFHSGYDFGYFIKMLQNSDLDEDDEEFFKKLRLHCPDIYDVKYMMKSCKDLKGGLQEVSDYLQIKRVGPQHQAGSDSLLTGMAFFKMRELYFENNLESEKYSGHLYGLGPFVGNSSNVTNGGSYGEYDTTSDNGAQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZX03</accession>
    <name>A0A3S0ZX03_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_003500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000074">
        <property type="protein sequence ID" value="RUS88783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZX03"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018781207" evidence="1">
        <location>
            <begin position="20"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS88783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="130" mass="13270" checksum="8A124D66983C585F" modified="2019-04-10" version="1">MTNNASLLIAAAVLAAACASPCTDSCFGTCELSASGSRTFLPFFAAFVEPGRDGCRALCAATCNCVDTCAAECGTQLASCREAEGNVFVHFLWCQAEFTACNAVCGTQCGMTITAGIMGRAINTLLPSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZXC2</accession>
    <name>A0A3S0ZXC2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_003893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000086">
        <property type="protein sequence ID" value="RUS88322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZXC2"/>
    <dbReference type="OrthoDB" id="6154305at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS88322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="421" mass="44374" checksum="02EF48172FCC8317" modified="2019-04-10" version="1">MYEDAPTSTLDSAAFKALLSVAVVAVAALLALILAKLASHMYDRKIARRKERQPVDAEAADLVRARLAVMQFKRHRMGKGELTPQEASMRKTIGIWSYKGGRTLGPLKPPKKRPEPVDKTVSGMAAKHLDTKRERKVAQKADVDSQSPRTSGESPSISKEASNVNAKQSHIEISTTASSDTKATNVAGKEEVKKFPKPMDQVQLVSKVNKNVAVKPQSGLVQKLNNSGHNKVGTAPSNGAQGSLNEQSSTPKPSRELESQSSSHDTGDSANQTPRAPSSPGKGSASPRRLFTVVTPSVAREKDLKRQESTMSSKGVGKRTSDTQSMKSESGARGAAESENGGTIQAPPIKRPTTSHLSSRGQSAQKNTSSVGVAILSSNAGKQATNGKTPVSTVKVKPNTGVGVAKDDSSRADVAMAGAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZYZ3</accession>
    <name>A0A3S0ZYZ3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 24</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mediator complex subunit 24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_002605</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000051">
        <property type="protein sequence ID" value="RUS89587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZYZ3"/>
    <dbReference type="STRING" id="188477.A0A3S0ZYZ3"/>
    <dbReference type="OrthoDB" id="21216at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021429">
        <property type="entry name" value="Mediator_Med24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12898">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12898:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11277">
        <property type="entry name" value="Med24_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="422"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="904"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="422"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="916"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS89587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="925" mass="105473" checksum="7E7EEF7269D20026" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A0S4</accession>
    <name>A0A3S1A0S4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EGW08_004509</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">EC2010</strain>
            <tissue evidence="15">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Endomembrane system</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000102">
        <property type="protein sequence ID" value="RUS87763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A0S4"/>
    <dbReference type="OrthoDB" id="6140148at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026966">
        <property type="entry name" value="Neurofascin/L1/NrCAM_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF253">
        <property type="entry name" value="DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13882">
        <property type="entry name" value="Bravo_FIGEY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="557"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="19"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="112"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="239"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="340"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="592"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="592"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="634"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RUS87763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="685" mass="77064" checksum="D3695609A020DB6F" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A3M5</accession>
    <name>A0A3S1A3M5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA replication factor Dna2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_002497</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000048">
        <property type="protein sequence ID" value="RUS89794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A3M5"/>
    <dbReference type="STRING" id="188477.A0A3S1A3M5"/>
    <dbReference type="OrthoDB" id="6155569at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22318">
        <property type="entry name" value="DNA2_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051827">
        <property type="entry name" value="Cas4_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014808">
        <property type="entry name" value="DNA_replication_fac_Dna2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36531">
        <property type="entry name" value="CRISPR-ASSOCIATED EXONUCLEASE CAS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36531:SF6">
        <property type="entry name" value="DNA REPLICATION ATP-DEPENDENT HELICASE_NUCLEASE DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08696">
        <property type="entry name" value="Dna2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication factor Dna2 N-terminal" evidence="11">
        <location>
            <begin position="4"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS89794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="275" mass="30892" checksum="F7386B7A2A10FB65" modified="2019-04-10" version="1" fragment="single">MCGRKQETRQCALRGFWADTKVDPGDVVNVLADMEGGQFIVDDKKGLVVVNPDTLLSGTLVVSAVFCRRKSVLNEQFKGVDKGNVQMLYGSIIHSLFQEVLRDGVTQQKDVEALAVSKLKASKFLHEMYGQNLVEGTVTEEVKQYIPTLMDWLGKHTLLHNTGRRQLKSEKRPEVMVTEIQDIEENIWSPRFGLKGKIDLTVQAELSKKDTGLEVKVVPLELKTGKASFSSEHKGQVTLYSMMCSDRRTDPEEGILLYLKHGQMQRVPVKPESKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A5T2</accession>
    <name>A0A3S1A5T2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_000828</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000012">
        <property type="protein sequence ID" value="RUS91398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A5T2"/>
    <dbReference type="STRING" id="188477.A0A3S1A5T2"/>
    <dbReference type="OrthoDB" id="411785at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051419">
        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176:SF83">
        <property type="entry name" value="CITRATE SYNTHASE-LYSINE N-METHYLTRANSFERASE CSKMT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="4">
        <location>
            <begin position="74"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS91398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="263" mass="30229" checksum="CEB7EE77BA38F1AD" modified="2019-04-10" version="1">MLKCIFNLQKNTVISGDFHDEKLSKFSYWKNRYKYRNKDVFEWFLEPGEIVEPILNNIAHIQAQHSVGKTNSFLRYIDIGCGLSDLSLHVLIHCPRPLSAAMVDFVSEALQYQNKRMQEYQQMVQLNSESTLHLICADVLCLPFRAGEFDVAIDKGTMDALLKDKGQGHFKSGLLMAEVTRLLSPGGRYLQISDEDPDSRLLFLESISNTKRAAWNCGKRVEETHEESMCGAAPDFHKLSSWNFKSIQLKFGSEYFLYWAERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A9I4</accession>
    <name>A0A3S1A9I4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_006119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000150">
        <property type="protein sequence ID" value="RUS86099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A9I4"/>
    <dbReference type="STRING" id="188477.A0A3S1A9I4"/>
    <dbReference type="OrthoDB" id="8964251at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS86099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="248" mass="29190" checksum="DCCD896FB31408C1" modified="2019-04-10" version="1">MVTQAEQNVAVHAQESSQERNIQKLIEEHTKDYAEQLEEQQGVAERLKKEVKKRKESETQLQVELEDTREELNKKERMVVKLRASKTRLEGEVDDLEKKLEKISAARSQKAGEFEKQQELDDMRRKCRALEDQLSRQLAAEKPYEQKENQTKTEDAIRWEESKKWQRTIEKMKNKIKDKEAEISNLNATINRLKALLERSNREKEIQHRPLQKSSAHSLSAAPSSGRLDHEREDLRATIYRQQEEGMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AAT6</accession>
    <name>A0A3S1AAT6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyl-CoA thioesterase 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_005248</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000122">
        <property type="protein sequence ID" value="RUS87010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AAT6"/>
    <dbReference type="STRING" id="188477.A0A3S1AAT6"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025652">
        <property type="entry name" value="TesB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF34">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02551">
        <property type="entry name" value="Acyl_CoA_thio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase 2 C-terminal" evidence="2">
        <location>
            <begin position="57"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS87010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="136" mass="16033" checksum="89CE3C5BEC56AC10" modified="2019-04-10" version="1" fragment="single">VPFPDELSTPAESLKKFLEQDLIGPKRYEYRKKQIEEIPIVMKYIKEEQVVYRTDQRQTLWLKVKGHLPDDLHPNIHKCCLAYMSDMYLLSTATIPLKWLHGADIFATSLDHSMWFHAPARADEWMLYDVQIDKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AW73</accession>
    <name>A0A3S1AW73_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_022306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001532">
        <property type="protein sequence ID" value="RUS69934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AW73"/>
    <dbReference type="STRING" id="188477.A0A3S1AW73"/>
    <dbReference type="OrthoDB" id="6161336at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS69934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="226" mass="24774" checksum="F6F4392B85E18012" modified="2019-04-10" version="1">MNAKDPPGMAIGKIRHLSRLREPGGDNIGTVSYPCLPWSSIDPPVLAFFAALVQLRLSKHHLQWAPLNSVALQCSISNRCQWRKSSVLETAPADHAVHSATAPRFNGTQPRYVPASLASANNVYVRKDSNKRPLQRSYDVLISSPKKSDNYFTLEIKGRSETVSIDRLKAAYVTQLMDGNSNKPVNSPDHLLTPDSKPVTGILTPGATPEDNTRVTTRAGRVPCRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AWC2</accession>
    <name>A0A3S1AWC2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_023216</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="RQTK01001861">
        <property type="protein sequence ID" value="RUS69023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AWC2"/>
    <dbReference type="STRING" id="188477.A0A3S1AWC2"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000495">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000004">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011678">
        <property type="entry name" value="PRK15098.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF10">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type III-like" evidence="8">
        <location>
            <begin position="530"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS69023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="580" mass="63497" checksum="B0212C50CEDACF7B" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AY46</accession>
    <name>A0A3S1AY46_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL45</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L45, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_020898</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrion-specific ribosomal protein mL45 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001230">
        <property type="protein sequence ID" value="RUS71333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AY46"/>
    <dbReference type="STRING" id="188477.A0A3S1AY46"/>
    <dbReference type="OrthoDB" id="19619at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051975">
        <property type="entry name" value="mtLSU_mL45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007379">
        <property type="entry name" value="Tim44-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28554">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L45, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28554:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04280">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tim44-like" evidence="10">
        <location>
            <begin position="10"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="110"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS71333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="152" mass="17598" checksum="9AD853CB6CB2F1A7" modified="2019-04-10" version="1">MVHGLETKTMRWSLTETVEPARVVHIRTEEVLTSDNLFAQVTVRLHTKQILAIYDRFGRLMYGDPKLAKSVVEYVIFEKWISDTYGRWRIHGKIIPQWMEPRDSLIKTYRVPNFGPLPPEEPDDKDDKSVKKNNDDDGGDEEGTSRPRLATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AYD7</accession>
    <name>A0A3S1AYD7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_016849</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000746">
        <property type="protein sequence ID" value="RUS75387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AYD7"/>
    <dbReference type="STRING" id="188477.A0A3S1AYD7"/>
    <dbReference type="OrthoDB" id="659at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS75387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="31817" checksum="78A405EF7FD940AB" modified="2019-04-10" version="1" fragment="single">GGSWISTGAYGSRFARIAFRRHFYQLCGFRLAKSKDLEAELPAKAVNTGVYIVGAGEEENKNSQENCAQKVAWEPSSNTAYQFDTTETLEGILELEFGFRDSLAAAVARFCSNYCTCNNISTKSVVHIGAATGRTAFELSKTFEHVLGLEPFARLIDTAIKLQGGETVVLKNGQPVQMDPEYQLDKINLKQFTWVANEVDIHDLVLLTHLDRVQNAKAWFLRLWEIVNLKGIVAVVSRDDMWNKKSLNTELNDRLEFVTEQKLVFLDTKGKGSASITLWRRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B2D3</accession>
    <name>A0A3S1B2D3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_018888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000946">
        <property type="protein sequence ID" value="RUS73353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B2D3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS73353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="104" mass="12641" checksum="B72ADE29F7125773" modified="2019-04-10" version="1">MIKDSNRKAVIIRKVQHQQTEQQHHHHHNHNHHHNHQPHQPQPHRLASLHPSNYQHLQHRNQYHQNHHHHHSHHHQHHHQQQQLTFPSAPGRHAESWPCHPAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B2Z2</accession>
    <name>A0A3S1B2Z2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_018464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000902">
        <property type="protein sequence ID" value="RUS73771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B2Z2"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48147:SF3">
        <property type="entry name" value="MYELIN TRANSCRIPTION FACTOR 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48147">
        <property type="entry name" value="PROTEIN CBG23787"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS73771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="246" mass="29018" checksum="EB41B5E57A4721EF" modified="2019-04-10" version="1">MLSHRLLSNRVAKTNIVHKLRVCPKAEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEAEEDQRGWKWNLRHDLGNLTMGAFPPDELTDEHRRNGMTFPREIGDGGGRNGVRDNKSEKKSHQHQGSFSRVDMIRTLLINIRYATEWWDQTLPGLTKVGFFGKGQQEVKIYKRFRFCGTDSPLPEFRPANHQEKTSPSRVGFVNPSSAHSLPESSHFSSDKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B4I5</accession>
    <name>A0A3S1B4I5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amine oxidase</fullName>
            <ecNumber evidence="8">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_017352</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="8">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="7">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="7 8">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="8"/>
    <dbReference type="EMBL" id="RQTK01000790">
        <property type="protein sequence ID" value="RUS74887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B4I5"/>
    <dbReference type="STRING" id="188477.A0A3S1B4I5"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF20">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00766">
        <property type="entry name" value="CUDAOXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0801">TPQ</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="592"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="12">
        <location>
            <begin position="90"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="11">
        <location>
            <begin position="341"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="11">
        <location>
            <begin position="619"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="321"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="413"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="6">
        <location>
            <position position="501"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="7">
        <location>
            <position position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS74887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="786" mass="88106" checksum="02FFE57226A7B312" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B5T5</accession>
    <name>A0A3S1B5T5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_015451</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000636">
        <property type="protein sequence ID" value="RUS76774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B5T5"/>
    <dbReference type="STRING" id="188477.A0A3S1B5T5"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000683">
        <property type="entry name" value="Abc transporter f family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000104">
        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF15">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="81"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="386"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS76774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="608" mass="69164" checksum="1556B906D63AC3C7" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B745</accession>
    <name>A0A3S1B745_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Transcription elongation factor SPT4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_010802</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the SPT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000338">
        <property type="protein sequence ID" value="RUS81418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B745"/>
    <dbReference type="STRING" id="188477.A0A3S1B745"/>
    <dbReference type="OrthoDB" id="248751at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07973">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.210:FF:000001">
        <property type="entry name" value="Transcription elongation factor SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009287">
        <property type="entry name" value="Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022800">
        <property type="entry name" value="Spt4/RpoE2_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038510">
        <property type="entry name" value="Spt4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882">
        <property type="entry name" value="SUPPRESSOR OF TY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06093">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025023">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01389">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="10 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Spt4/RpoE2 zinc finger" evidence="13">
        <location>
            <begin position="13"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR025023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS81418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="117" mass="13393" checksum="65696984182A7DA6" modified="2019-04-10" version="1">MSLETIPKDLRGLRACLLCSLIKTMDQFEFDGCENCQDVLHMKNNRDIVIECTSANFEGMIALMSPEDSWVAKWQRIERMVKGCYAVSVTGSLPPRFVRELRAKGRVYNSRDVSNRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B8G8</accession>
    <name>A0A3S1B8G8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_014661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000570">
        <property type="protein sequence ID" value="RUS77585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B8G8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS77585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="98" mass="11316" checksum="80AF96607A6CCC31" modified="2019-04-10" version="1" fragment="single">ITAHPLPKPISRAHSCLPKTQGSIFAATGVQFPIRRETHTVHWSKKPLCIHTHLFSSIIIKLVHLEVFSTTHKKVLRRMKRSCVHRCWCLYLLDLLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B9C8</accession>
    <name>A0A3S1B9C8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_009356</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000267">
        <property type="protein sequence ID" value="RUS82891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B9C8"/>
    <dbReference type="STRING" id="188477.A0A3S1B9C8"/>
    <dbReference type="OrthoDB" id="10036964at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF233">
        <property type="entry name" value="THYROTROPIN-RELEASING HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="331"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="72"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS82891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="406" mass="45210" checksum="CD2CE237FBE50030" modified="2019-04-10" version="1" fragment="single">MDTRLCCLDQQGSSCTGCELNSSTRGLFGNGSSEGPPRDLPEEDPPNLGPPLYMYIYVTVVNVLVLLVGITGNVLVIQVVARTKSMRRRINYFLISLSAADLLVLVVCLPIALLEFYGKERWYIGEAMCKIVPFLENMSHHCSVLTLLVIGFERYHAICHPLKETTSRRYLSVSLMVPVVWAVSIVVSLPFAIISSTKKTIYYDDSVVDICRTDTTSKQARGFIIFIFVVFLVLPLLLLTAMYTAIIRSSTVSVNTAGSVGGTSASGRHYCGPDSETVRHPRVQSSRRQVVRMMVAVMALYFCCLMPMRCVQLWVVFGPDEDIERLGFEGYLNLICCVRILIMVNSAGNPIIYGLLSSNFRSAFRQSLCCCRGSARNGGLRYNTTYYSNTNSHHQHYLQVHTQGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BB66</accession>
    <name>A0A3S1BB66_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">T-complex protein 1 subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_012246</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000417">
        <property type="protein sequence ID" value="RUS79981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BB66"/>
    <dbReference type="STRING" id="188477.A0A3S1BB66"/>
    <dbReference type="OrthoDB" id="275057at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03337">
        <property type="entry name" value="TCP1_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000069">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000073">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000005">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012719">
        <property type="entry name" value="Chap_CCT_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02344">
        <property type="entry name" value="chap_CCT_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="531"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="535"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS79981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="552" mass="60708" checksum="AA5CDBD53294CE96" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BHJ2</accession>
    <name>A0A3S1BHJ2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_003773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000082">
        <property type="protein sequence ID" value="RUS88436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BHJ2"/>
    <dbReference type="STRING" id="188477.A0A3S1BHJ2"/>
    <dbReference type="OrthoDB" id="5985425at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS88436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="13359" checksum="D35AD237359493B5" modified="2019-04-10" version="1" fragment="single">SYDAVTASGCFCAGHVPCTAIFEIFRLLKPGGYFLNCMREEYLYEVPEYKDRLVRMLNDLEKQGLIKSVEWTVYPNHYVGKPGVRMIYQKLNTQARTPKDVQTICENVKDTRDNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BIR5</accession>
    <name>A0A3S1BIR5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_002940</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000060">
        <property type="protein sequence ID" value="RUS89266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BIR5"/>
    <dbReference type="STRING" id="188477.A0A3S1BIR5"/>
    <dbReference type="OrthoDB" id="6155318at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005283">
        <property type="term" value="F:amino acid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089718">
        <property type="term" value="P:amino acid import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF321">
        <property type="entry name" value="SODIUM-DEPENDENT NUTRIENT AMINO ACID TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS89266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="253" mass="29738" checksum="01F71D14EBB533B1" modified="2019-04-10" version="1">MLLSMTECLVISWIYGVDRFMKDIQLMTGNKPSIYWKIMWKFVTPIVVLTIWIFNLYQMQRVSLDDYQYPEWAVMVGWSFALISILPLPIYAIYAVIQVESGSFRQRILLLIQPTANFGPSQIEDRERYFQTFNDFDWLRYNAAKNRMDWRTYKKYEAGKDKSSSNIAPDNHLPAVSTEDINILVEKMTSQQKLFLGGMFLEEAGDCQKLIEENNEVLGQVENEQTGHRETRYWDFDESLNGKNGKHTRCYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BJ28</accession>
    <name>A0A3S1BJ28_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_002734</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000054">
        <property type="protein sequence ID" value="RUS89501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BJ28"/>
    <dbReference type="STRING" id="188477.A0A3S1BJ28"/>
    <dbReference type="OrthoDB" id="10014807at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="480"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="218"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="518"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="575"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="627"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="644"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="660"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="700"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="722"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="732"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="749"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="800"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="876"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS89501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="937" mass="107934" checksum="2FE02E84599BBBE4" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BKM9</accession>
    <name>A0A3S1BKM9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Neurotransmitter-gated ion-channel ligand-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">EGW08_022834</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">EC2010</strain>
            <tissue evidence="18">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Synaptic cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001694">
        <property type="protein sequence ID" value="RUS69403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BKM9"/>
    <dbReference type="STRING" id="188477.A0A3S1BKM9"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18997">
        <property type="entry name" value="LGIC_ECD_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000043">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000028">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="748"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="16">
        <location>
            <begin position="4"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="17">
        <location>
            <begin position="224"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="364"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RUS69403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="795" mass="89228" checksum="AB464EF69BB6CEC1" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BPW3</accession>
    <name>A0A3S1BPW3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_020285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001136">
        <property type="protein sequence ID" value="RUS71957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BPW3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018757514" description="EGF-like domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS71957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="21082" checksum="A06A8B5AF9ED7E32" modified="2019-04-10" version="1" fragment="single">MLVLCFAPYFIMVALVTIPPASPTPSSTTKPLRTDTYGVQNVIDQQVTIGAQAENSHSFTDNGAQSTVSSSAGNGAVPLPNTAQDKSEYSQQMTTGPREIGTSTLPGDEDDGLVVSTETFAPSRIGTTLRPESERTCFPGVVCKHGVCDFAKCACDLGWFGPLCDVTCVPACPAHQSCLATDDLWNPKCVCDRPLDCDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BS33</accession>
    <name>A0A3S1BS33_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_004799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000111">
        <property type="protein sequence ID" value="RUS87424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BS33"/>
    <dbReference type="STRING" id="188477.A0A3S1BS33"/>
    <dbReference type="OrthoDB" id="6131156at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="14"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS87424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="296" mass="32702" checksum="9146809EB090487D" modified="2019-04-10" version="1">MSSPGPNWRCCSPGRGGVSLAEKAVRNGGAGIYIKYPGGEEDKISIPTGVFSTNYKAEATAIQEGAAHVQSSPHSTKNIVFLTDALSVLQALKSSKNKDLNDLTSALTSLSQTHTIALQWIPSHCNVFGNETADLLAKKAAALQQNDYTTTYSEAKTIIHAQQHEEWLQQHPNHVQNDAYHALTRAEQVVIFRLRTGHNCLNHHLYTKLHIGTSDQCTCQTGGQTVIHVLQHCPMYENIRNLMWPQDTPMAQKLYGSLEDLRRTATFMSETGLSIRVNAKKKKKKKPSQCIVGSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BTC7</accession>
    <name>A0A3S1BTC7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_001116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000018">
        <property type="protein sequence ID" value="RUS91091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BTC7"/>
    <dbReference type="OrthoDB" id="371494at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS91091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="118" mass="13832" checksum="AF71E1A493741B9B" modified="2019-04-10" version="1" fragment="single">ITVIDKYIAVIDTYITVIDRLITLIDKYITVIDKYITVIDKYITVIIDKYITVIETYLTVIDKYVSVIDKYITLKDKHITVIGKYITVIDKYITVIDKLITLIEKYITVIDKYITIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BVU6</accession>
    <name>A0A3S1BVU6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_016144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000687">
        <property type="protein sequence ID" value="RUS76113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BVU6"/>
    <dbReference type="STRING" id="188477.A0A3S1BVU6"/>
    <dbReference type="OrthoDB" id="7477027at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS76113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="330" mass="33847" checksum="DDD56D90C1A96EFD" modified="2019-04-10" version="1" fragment="single">MPGPTEDTNSTMPGPTDNTNSTMPGPTDNTNSTKPGSTDDTNSTMPGPTEDTNSTMPGPTDNTNSTKPGSTEDTNSTMPGPTEGGTAQTDSATNSTDGPNETEASVTPVSTTQTPAGTSTAKPQNLDARISETNLLLAGADEADSLFIELTGGAGQSLAGVWLVVRDAGPGAVLQLSLKLDAWAADNATGLCVLDSSSGLALAQLATAQAVFVGLYAAEPADSLTLTDVLDALLYSTSDTALDQSLAETFGPVTRFPLTLDHSQLAGLGEQSLSLSRCPRASGDKSNAAFLLAHSSPGNENGCAMPNSHPEEMWLSIRKQPCPDRLPESF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BWR9</accession>
    <name>A0A3S1BWR9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_001567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000027">
        <property type="protein sequence ID" value="RUS90667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BWR9"/>
    <dbReference type="OrthoDB" id="5954868at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.530.10">
        <property type="entry name" value="Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012444">
        <property type="entry name" value="DUF1647"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31389">
        <property type="entry name" value="LD39211P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31389:SF4">
        <property type="entry name" value="LD39211P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07801">
        <property type="entry name" value="DUF1647"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="744"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="821"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS90667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="850" mass="94982" checksum="471161F50CA1367F" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BWX1</accession>
    <name>A0A3S1BWX1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_001421</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000024">
        <property type="protein sequence ID" value="RUS90802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BWX1"/>
    <dbReference type="STRING" id="188477.A0A3S1BWX1"/>
    <dbReference type="OrthoDB" id="661148at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004939">
        <property type="entry name" value="APC_su10/DOC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040099">
        <property type="entry name" value="ZZEF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22772">
        <property type="entry name" value="NOVEL ZZ TYPE ZINC FINGER DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22772:SF4">
        <property type="entry name" value="ZINC FINGER ZZ-TYPE AND EF-HAND DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03256">
        <property type="entry name" value="ANAPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01337">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51284">
        <property type="entry name" value="DOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOC" evidence="2">
        <location>
            <begin position="117"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="455"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS90802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="623" mass="69260" checksum="63A8C2218492E220" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C3U0</accession>
    <name>A0A3S1C3U0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Neurotransmitter-gated ion-channel ligand-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_009997</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000296">
        <property type="protein sequence ID" value="RUS82221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C3U0"/>
    <dbReference type="STRING" id="188477.A0A3S1C3U0"/>
    <dbReference type="OrthoDB" id="410315at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="2">
        <location>
            <begin position="65"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS82221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="290" mass="32667" checksum="DA9986676419FFF5" modified="2019-04-10" version="1">MEVGGSTTEQFVPHPPPNHPEKATWCQLGEKSDHLTQQTSSDVRNVICIVAGLETSASSRFGPVISRLRKKSDPDVMPFAKEGGPLEVSLTLNIINIASVNPKRGEVEVLVWQAMSWRNSDLAWWPPDHKNVTSVRIHPKYLWTPDITIFNNARATEEVTPPIASVDSDGTVTLLPSLRIRVLCDLSDMTLNRFLDEQMAICEIRMGSWTYGADILTLVKPESENLGTSSYSQGSEFNLLDVRAKKNVFYYPCCDEPYEDLKFFFTFSRKRQVNTWSADGGLLHEKIRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C9P6</accession>
    <name>A0A3S1C9P6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_005528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000130">
        <property type="protein sequence ID" value="RUS86738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C9P6"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS86738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="107" mass="13209" checksum="C892554EF1116781" modified="2019-04-10" version="1">MLVFLSFSFYKSYHWYWLFFVLHFILMYCLNKGFNFFSEFILNHKLFCHSLPKYFYIFLLLLLTIMITLSLHNNMSQLDVMRFSCCCFFCCCFLTIFYTFSQIPMYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1CBF0</accession>
    <name>A0A3S1CBF0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">oleoyl-[acyl-carrier-protein] hydrolase</fullName>
            <ecNumber evidence="2">3.1.2.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_004107</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.14" evidence="2"/>
    <dbReference type="EMBL" id="RQTK01000092">
        <property type="protein sequence ID" value="RUS88145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1CBF0"/>
    <dbReference type="STRING" id="188477.A0A3S1CBF0"/>
    <dbReference type="OrthoDB" id="541883at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016297">
        <property type="term" value="F:fatty acyl-[ACP] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487:SF0">
        <property type="entry name" value="S-ACYL FATTY ACID SYNTHASE THIOESTERASE, MEDIUM CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="13"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS88145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="252" mass="28936" checksum="0812677A46210DFB" modified="2019-04-10" version="1">MNCRFKKPYASVRLFCFPGAGAGTSFYTQWGRELSDNIEVHAVCLPGRDNRQKEPLCNTKKDTVDSIVESLQNGLLDKPFAFWGHSMGAILSFWVALELKRKCNKEPVHMFLSSAMPPNSTGFKNIVRFSMSDDEYFEHALNTFSDGLPKDITQNKDMMDVFLPIWKSDLSLLRKLSYEKNSDEEPPLSCLIDVFCGQGEDLDVINYLDEWNELTRETASKHFMPGDHFYLNEKANVKKIQSFIETKFEDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1CD45</accession>
    <name>A0A3S1CD45_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rieske domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_002749</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000055">
        <property type="protein sequence ID" value="RUS89452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1CD45"/>
    <dbReference type="STRING" id="188477.A0A3S1CD45"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03467">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21496">
        <property type="entry name" value="FERREDOXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21496:SF0">
        <property type="entry name" value="RIESKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="6">
        <location>
            <begin position="12"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS89452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="122" mass="13561" checksum="AB8B2756ADEA4F78" modified="2019-04-10" version="1">MTDSATDTDPQWHFLGNVAELKQQESRKVYLKSGAPLVLFYLDPDRFFVCSTVCPHAKGPLDQGDIEDLGDTVQVTCPLHFYSFDLTSGESSSGLKLKTYKTEIRGDKLFVACPEPISLKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1CGP0</accession>
    <name>A0A3S1CGP0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Palmitoyl-protein thioesterase 1</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Palmitoyl-protein hydrolase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_000135</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palmitoyl-protein thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="RQTK01000002">
        <property type="protein sequence ID" value="RUS92111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1CGP0"/>
    <dbReference type="STRING" id="188477.A0A3S1CGP0"/>
    <dbReference type="OrthoDB" id="10263094at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000107">
        <property type="entry name" value="Palmitoyl-protein thioesterase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002472">
        <property type="entry name" value="Palm_thioest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF8">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02089">
        <property type="entry name" value="Palm_thioest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00414">
        <property type="entry name" value="PPTHIESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018608743" description="Palmitoyl-protein thioesterase 1" evidence="9">
        <location>
            <begin position="24"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS92111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="302" mass="33960" checksum="726B7CEC32E3CB83" modified="2019-04-10" version="1">MVASTKMILYAAALFLLVPLTTPQAGPVPVVLWHGMGDSCCNPLSMGSIKRLVEQKVGDGVYVKSLMIGSNIVQDTENGFFMNANDQVANVCAQLKNDPKVQQGYNAMGFSQGGQFLRAVAQRCPSPPMLNLISFGGQHQGVYGFPHCPGENQTLCDEVRKLLNFGAYIPWIQDFLAQAEYWHDPLNEAEYREKSVFLADINQEKNFNQTYKTNLLKLKNMVLVKFAYDTMVDPKESEWFGFYNEGQGVKLYNMTQSKLYQQDLIGLKELNESGRIALLESPGDHLQFTDAWFEANILKFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H0C9</accession>
    <name>A0A3S1H0C9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_022519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001596">
        <property type="protein sequence ID" value="RUS69719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H0C9"/>
    <dbReference type="STRING" id="188477.A0A3S1H0C9"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101967">
        <property type="entry name" value="Adhesin YadA, collagen-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS69719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="263" mass="29259" checksum="19222AA264C110AA" modified="2019-04-10" version="1" fragment="single">RDKRTLGSTSHTQSRDKRTLGSTSHTQSRDKRTLGSTSHTQSRDKRTLGSTSHTQSRDKRTLGSTSHTQSRDKRTLGSTSHTQSRDKRTLGSTSHTQSRDKRTLGSTSHTQSRDKRTLGSTSHTQSRDKRTLGSTSHTQSRDKRTLGSTSHTQSRDKRTLGSTSHTQSRDKRTLGSTSHTQSRDKRTLGSTSHTQSRDKRTLGSTSHTQSRDKRTLGSTSHTQSRDKRTLGSTSHTQSRDKRTLGSTSHTQSRDKRTLGSTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H109</accession>
    <name>A0A3S1H109_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Titin-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_022175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001500">
        <property type="protein sequence ID" value="RUS70060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H109"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS70060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="657" mass="70892" checksum="4C6F171967286BAE" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H521</accession>
    <name>A0A3S1H521_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_019900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001078">
        <property type="protein sequence ID" value="RUS72342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H521"/>
    <dbReference type="STRING" id="188477.A0A3S1H521"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043539">
        <property type="entry name" value="Grb2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46037">
        <property type="entry name" value="PROTEIN ENHANCER OF SEVENLESS 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="5">
        <location>
            <begin position="35"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="156"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS72342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="215" mass="25040" checksum="2FD630DD5257FED0" modified="2019-04-10" version="1">MEAKALYDFEATQADEMSFKKGNTVCVTSTEDGGWYKAVMGKRSGYIPATYIKFEKNDWYHPITRLEAEKLILKKNSLGSYINPDGYYLIRKSDKEFALSVKHEDTVQHFKILCDGNNKFYIWPNNVFSSINELVSNYHVENVSGDHRKIIQLRDIEQELYEALYDFTPANDEEIPLKRGDIIRLVCKSDENWWEGEVDGKTGFFPKIYVKEYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HEM6</accession>
    <name>A0A3S1HEM6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_014476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000554">
        <property type="protein sequence ID" value="RUS77771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HEM6"/>
    <dbReference type="STRING" id="188477.A0A3S1HEM6"/>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051049">
        <property type="entry name" value="Dienelactone_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46623:SF6">
        <property type="entry name" value="ALPHA_BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46623">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS77771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="229" mass="24890" checksum="0CC3086E413C8EC2" modified="2019-04-10" version="1">MSRVEVPSENKLGACPAMVFGDVSKAAAAIIVMQEWWGMNGHILDTAKQISERSGLVTLVPDIYRGKVAQDRETAGHYSADLDWKGAVADVVACAKFLKEGGCRKVGITGFCQGGAMTLAVIASSEILDAGAPFYGIPNKSGLQLDYNNIKCPLQCHFGEEDEVVGLSSPADYTALQAKLTKLNKEFEFYTYKAGHGFANPTRPNFNKDAAELSFSRMYSFFEKHLKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HTL8</accession>
    <name>A0A3S1HTL8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2</fullName>
            <ecNumber evidence="1">2.1.1.296</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_006309</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67024"/>
            <dbReference type="Rhea" id="RHEA-COMP:17169"/>
            <dbReference type="Rhea" id="RHEA-COMP:17170"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167612"/>
            <dbReference type="ChEBI" id="CHEBI:167614"/>
            <dbReference type="EC" id="2.1.1.296"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.296" evidence="1"/>
    <dbReference type="EMBL" id="RQTK01000156">
        <property type="protein sequence ID" value="RUS85906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HTL8"/>
    <dbReference type="STRING" id="188477.A0A3S1HTL8"/>
    <dbReference type="OrthoDB" id="429597at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004483">
        <property type="term" value="F:methyltransferase cap1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120550">
        <property type="term" value="F:methyltransferase cap2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025807">
        <property type="entry name" value="Adrift-typ_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050851">
        <property type="entry name" value="mRNA_Cap_2O-Ribose_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16121">
        <property type="entry name" value="CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16121:SF2">
        <property type="entry name" value="CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51614">
        <property type="entry name" value="SAM_MT_ADRIFT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adrift-type SAM-dependent 2'-O-MTase" evidence="9">
        <location>
            <begin position="45"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="519"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="766"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="533"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="769"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS85906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="788" mass="89248" checksum="05A6615822360A4F" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HUT3</accession>
    <name>A0A3S1HUT3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_005754</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000137">
        <property type="protein sequence ID" value="RUS86504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HUT3"/>
    <dbReference type="STRING" id="188477.A0A3S1HUT3"/>
    <dbReference type="OrthoDB" id="286734at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF4">
        <property type="entry name" value="LYSOPHOSPHOLIPID ACYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS86504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="290" mass="31703" checksum="205077197A878CA1" modified="2019-04-10" version="1" fragment="single">MTFFERMMFLLGVMTLAKHKYYFAWILGDALNNAAGLGFSGYDAQGNPQFDLTDNVDVYGVEFSSSLKVNIDSWNKKTLIWLRRVVYDRAPVHNTLAVFACSALWHGFYPAYYISFGSGALMTIVARQVRRKIRPHFQTSSSLKFFYDVLTFTACRFANPYLAMPFLVLEFQACYLMFKSLYFYLHILTLVGFIVLLFVPTPRQGRPPSSRASADAGNPAIVQSDPATAQAVDSSQGAQLHSNDAAHVGTDGTAVVKRAALGTDSGKSNGIPATNGTIVGAMGEGQAGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1I1Y8</accession>
    <name>A0A3S1I1Y8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TBC1 domain family member 15</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GTPase-activating protein RAB7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_001609</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with non-phosphorylated form of RAB8A; phosphorylation of RAB8A at 'Thr-72' disrupts this interaction. Interacts with ARMC12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000028">
        <property type="protein sequence ID" value="RUS90612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1I1Y8"/>
    <dbReference type="STRING" id="188477.A0A3S1I1Y8"/>
    <dbReference type="OrthoDB" id="10264062at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000005">
        <property type="entry name" value="TBC1 domain family member 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000005">
        <property type="entry name" value="TBC1 domain family member 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021935">
        <property type="entry name" value="SGSM1/2_RBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF645">
        <property type="entry name" value="LD27216P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12068">
        <property type="entry name" value="PH_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="11">
        <location>
            <begin position="307"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="673"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="673"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00055283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00065268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00082539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS90612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="696" mass="78860" checksum="9E7AFBC55B02570D" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SJJ3</accession>
    <name>A0A433SJJ3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_022967</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001751">
        <property type="protein sequence ID" value="RUS69270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SJJ3"/>
    <dbReference type="OrthoDB" id="6774133at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS69270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="24757" checksum="2BF5C02AFB59990B" modified="2019-05-08" version="1">MPQPFWAPLLSKALKGIVGEHKSVTKLRSSELLVECCSEAQVKRLGKIDTFDNIPVTVKAPGILHRLSSLKQRNLNLHLELDYKTTWKKIETKYENIDNVKVRKPPPWEQYSVKFDTSLTEFEKGNTNALVLQKEFLNLKEQCNEYYEIYTDGSKQDHKVAAAFFLPADPGDSDSARLRDRSSVFSAELEAILMAIKMRLACILIHVYQFTVKRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SJY3</accession>
    <name>A0A433SJY3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cep57 centrosome localisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_022963</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the translokin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001749">
        <property type="protein sequence ID" value="RUS69275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SJY3"/>
    <dbReference type="STRING" id="188477.A0A433SJY3"/>
    <dbReference type="OrthoDB" id="76453at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051756">
        <property type="entry name" value="Centrosomal_MT-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025913">
        <property type="entry name" value="Cep57_CLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024957">
        <property type="entry name" value="Cep57_MT-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19336:SF9">
        <property type="entry name" value="SPINDLE POLE BODY PROTEIN PPC89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19336">
        <property type="entry name" value="UNCHARACTERIZED DUF1167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14073">
        <property type="entry name" value="Cep57_CLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06657">
        <property type="entry name" value="Cep57_MT_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cep57 centrosome localisation" evidence="10">
        <location>
            <begin position="96"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Cep57 centrosome microtubule-binding" evidence="9">
        <location>
            <begin position="425"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="194"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="283"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="406"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="487"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="94"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="413"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="499"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="528"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="538"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS69275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="600" mass="66755" checksum="BD3AF920EEFA2807" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SNV6</accession>
    <name>A0A433SNV6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Guanylate kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_021403</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001325">
        <property type="protein sequence ID" value="RUS70832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SNV6"/>
    <dbReference type="STRING" id="188477.A0A433SNV6"/>
    <dbReference type="OrthoDB" id="6334211at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:GMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000828">
        <property type="entry name" value="leucine-rich repeat and guanylate kinase domain-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117">
        <property type="entry name" value="GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117:SF18">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND GUANYLATE KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="3">
        <location>
            <begin position="382"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="623"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="720"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="852"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="640"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="728"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="753"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="772"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="799"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="814"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="875"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS70832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="898" mass="98050" checksum="12FF46624820C647" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SQZ4</accession>
    <name>A0A433SQZ4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_020579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001179">
        <property type="protein sequence ID" value="RUS71655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SQZ4"/>
    <dbReference type="OrthoDB" id="6049596at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS71655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="159" mass="18887" checksum="32CB05D39C73FCB0" modified="2019-05-08" version="1" fragment="single">MTGSKPCESSKHLNPTQQNDRDIRFWRRCAAEPHCIRLLPENQPRTRNEAIMRRVVNPGDRRSYFDHKGRFMYPTRPVAMEIDAMRERRRQSLQVVRRHTEVLKSIVMKQQFKPETPDMDLAAMRERLTKVKREHAQQMLQRQKLPPMGTLRNGGTPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SV65</accession>
    <name>A0A433SV65_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_019066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000969">
        <property type="protein sequence ID" value="RUS73174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SV65"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS73174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="111" mass="11985" checksum="3F6B32AFA6158638" modified="2019-05-08" version="1" fragment="single">CGVTCLSGLVFVSAPPAQYLCRDSPGPHWTPGLAVPRCGRSLPSDYTVHLDLNLSYQGSSRAHACLEEMERAVADLVLLKVQQTCLRGLILGNIRISPVTDIFTSDTPFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SW84</accession>
    <name>A0A433SW84_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_018691</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000925">
        <property type="protein sequence ID" value="RUS73550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A433SW84"/>
    <dbReference type="OrthoDB" id="63891at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048491">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567">
        <property type="entry name" value="CLASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567:SF87">
        <property type="entry name" value="CRESCERIN-LIKE PROTEIN CHE-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21041">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOG" evidence="5">
        <location>
            <begin position="22"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="5">
        <location>
            <begin position="276"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="5">
        <location>
            <begin position="1239"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="5">
        <location>
            <begin position="1519"/>
            <end position="1757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="582"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="725"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="983"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1055"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1159"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1472"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="611"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="627"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="671"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="738"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="830"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="857"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="899"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="921"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="986"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1063"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1089"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1159"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1195"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1212"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1488"/>
            <end position="1510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS73550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1757" mass="194866" checksum="B49201E545575EA1" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SWY1</accession>
    <name>A0A433SWY1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ARID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_018442</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000898">
        <property type="protein sequence ID" value="RUS73803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SWY1"/>
    <dbReference type="STRING" id="188477.A0A433SWY1"/>
    <dbReference type="OrthoDB" id="757982at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20146">
        <property type="entry name" value="PWWP_ZCWPW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042778">
        <property type="entry name" value="ZCWPW1/ZCWPW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011124">
        <property type="entry name" value="Znf_CW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15999">
        <property type="entry name" value="ZINC FINGER CW-TYPE PWWP DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15999:SF6">
        <property type="entry name" value="ZINC FINGER CW-TYPE PWWP DOMAIN PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07496">
        <property type="entry name" value="zf-CW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51050">
        <property type="entry name" value="ZF_CW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CW-type" evidence="7">
        <location>
            <begin position="42"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="PWWP" evidence="5">
        <location>
            <begin position="116"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="ARID" evidence="6">
        <location>
            <begin position="397"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="588"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS73803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="638" mass="72348" checksum="9354D159730C2B5A" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SY26</accession>
    <name>A0A433SY26_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sjoegren syndrome nuclear autoantigen 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_018056</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000857">
        <property type="protein sequence ID" value="RUS74188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SY26"/>
    <dbReference type="STRING" id="188477.A0A433SY26"/>
    <dbReference type="OrthoDB" id="295355at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033362">
        <property type="entry name" value="SSNA1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28661:SF1">
        <property type="entry name" value="MICROTUBULE NUCLEATION FACTOR SSNA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28661">
        <property type="entry name" value="SJOEGREN SYNDROME NUCLEAR AUTOANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS74188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="13741" checksum="103BB029E3340FD3" modified="2019-05-08" version="1">MSMQGAALQSYNNELVKCIEELCGKRDEIHKSILQEEEEKQKLQNDIRVLTERLAKVNESLAKKMASRNEFDKTIAETETAYMKILESSQTLLNVLKRESQSLKEKSTPAPGAPTQRGGMPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SYA6</accession>
    <name>A0A433SYA6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_017968</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000849">
        <property type="protein sequence ID" value="RUS74266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SYA6"/>
    <dbReference type="STRING" id="188477.A0A433SYA6"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF375">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS74266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="524" mass="59319" checksum="ADB6DBB12AE16551" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SZX9</accession>
    <name>A0A433SZX9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit L</fullName>
            <shortName evidence="4">eIF3l</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_017395</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000794">
        <property type="protein sequence ID" value="RUS74838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SZX9"/>
    <dbReference type="STRING" id="188477.A0A433SZX9"/>
    <dbReference type="OrthoDB" id="15082at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03011">
        <property type="entry name" value="eIF3l"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019382">
        <property type="entry name" value="eIF3l"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10255">
        <property type="entry name" value="Paf67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="311"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS74838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="540" mass="63342" checksum="0372F1E54E15CAE4" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T123</accession>
    <name>A0A433T123_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_016988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000758">
        <property type="protein sequence ID" value="RUS75253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T123"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS75253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="204" mass="22862" checksum="194103E306B39287" modified="2019-05-08" version="1">MSVEVCMSALRASDGMPSGPAAFPHWRDFMVSAYFALLGGKEAQLVVGYLVGKQLRLGSGANSEEAAVMLQRISFTDFFPAVCLLAFFRLSLHFSFSDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDNDDDDDDDDNDDDDDDDDNDDDDDDDDNDDDDDDDDNDDDDDDDDDDDDDDDDDNDDDDDDDDDDDDDDDNDDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T2D9</accession>
    <name>A0A433T2D9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_016531</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000717">
        <property type="protein sequence ID" value="RUS75716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T2D9"/>
    <dbReference type="STRING" id="188477.A0A433T2D9"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001289">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050752">
        <property type="entry name" value="C2H2-ZF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384:SF189">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384">
        <property type="entry name" value="FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="302"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="328"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="499"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="527"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="659"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="688"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="714"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="757"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="785"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="811"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="901"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1014"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="405"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1111"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="408"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="428"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS75716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1167" mass="130558" checksum="6E474BFE33F10FF6" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T4M1</accession>
    <name>A0A433T4M1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_015716</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000656">
        <property type="protein sequence ID" value="RUS76523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T4M1"/>
    <dbReference type="OrthoDB" id="10051649at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15039">
        <property type="entry name" value="7tmB3_Methuselah-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053231">
        <property type="entry name" value="GPCR_LN-TM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902:SF1">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="649"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="685"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="716"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="761"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="806"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="854"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="881"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="648"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="925"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="925"/>
            <end position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS76523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="956" mass="107920" checksum="E5FEE5D3D2E0B518" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T4T2</accession>
    <name>A0A433T4T2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_015675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000652">
        <property type="protein sequence ID" value="RUS76567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T4T2"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS76567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="128" mass="14183" checksum="71BE259225C6D444" modified="2019-05-08" version="1" fragment="single">FFSGSLSPSHPWSLPFGCSFFRSGLPNEQGIAFYVTAERSGKRGSWREESKDLHTGVKTGQGLSSLEGDLEVRPEEPQQRYHGDHLATEREHGYSLGLPAGRRARVWGPSLGTEGNTWKRGGRCPVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T8H9</accession>
    <name>A0A433T8H9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_014338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000544">
        <property type="protein sequence ID" value="RUS77907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T8H9"/>
    <dbReference type="OrthoDB" id="10037961at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019096424" evidence="2">
        <location>
            <begin position="19"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS77907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="325" mass="36872" checksum="93179A22A915C3B3" modified="2019-05-08" version="1">MLEKFLFTFLRTILSICSETCPCQDKTRTVEGFHPCELTEDEKLFVYFSDGLNTLSEAEIKRIVPMIFRDYATQRDGVGIRHDPDPVLGKWMEAVKLEVETKLIGWFSISDATIYNLLRETQVEERNIFLNQILTLILKKILGEENNVWLIIYEADPQYFWPNSSASHLMICYPDMSGKPHRMPKKAFMVLSGSKCTKTQYHFKDKVELAVISAAAAAYNFGPLSVSLLGDALNVPSGAHSARLANSCARKRLNKSPLKNLDTEKRRRQSIEYSSEEYGTGRVHSADVNDTSGPKNYQIQLGCIPCLQLRHVGIRKGNDNLRTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T906</accession>
    <name>A0A433T906_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Notch ligand N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_014251</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000539">
        <property type="protein sequence ID" value="RUS77990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T906"/>
    <dbReference type="STRING" id="188477.A0A433T906"/>
    <dbReference type="OrthoDB" id="6146635at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011651">
        <property type="entry name" value="Notch_ligand_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07657">
        <property type="entry name" value="MNNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Notch ligand N-terminal" evidence="5">
        <location>
            <begin position="195"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS77990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="414" mass="45674" checksum="551DA700DA785227" modified="2019-05-08" version="1">MFGSGPWSSRPSSVLAELAELAELAELAELAELAELDLCRRFIGTCFRVSREARIGFLTCTATFRVSREARIVFLTCTATFRVSREARIGFLTCTATFRVSREASSLPVPLPSEVSREARIGFLTCTATFRVSREASSLPVPLPSEPGLGQGRPLNMASVKVPLVLALCAVFHIVLQVCSARAVVSIRFLTFRSSGLLDGSQCCDGKWGVCVFQCDPSFSICLDQGDSLITDMSRCSIGRAKHSGAIHNQLTISFGPRVGRLKNPVAWILDRWPFMFSGFSEAEGQGYALYQRVKVISTHGYDDTSSDLYPQHRERLTVRVNVSCGLGYFGLHCTEHCLASASDRYTCTRDGTKLCHTDDISLLSQKQQVAQEELYRVVAETGKTGLQINIGNTEAVRINNRQADLLWLYQENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T9V0</accession>
    <name>A0A433T9V0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_013866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000514">
        <property type="protein sequence ID" value="RUS78373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T9V0"/>
    <dbReference type="STRING" id="188477.A0A433T9V0"/>
    <dbReference type="OrthoDB" id="6275292at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033557">
        <property type="entry name" value="CIMAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010736">
        <property type="entry name" value="SHIPPO-rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34914">
        <property type="entry name" value="LYMPHOCYTE EXPANSION MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34914:SF1">
        <property type="entry name" value="LYMPHOCYTE EXPANSION MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07004">
        <property type="entry name" value="SHIPPO-rpt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS78373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="635" mass="69995" checksum="E77A76A147148264" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TAZ3</accession>
    <name>A0A433TAZ3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_013481</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000491">
        <property type="protein sequence ID" value="RUS78765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TAZ3"/>
    <dbReference type="STRING" id="188477.A0A433TAZ3"/>
    <dbReference type="OrthoDB" id="6073803at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="45"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS78765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="375" mass="42142" checksum="F3943B23401D4406" modified="2019-05-08" version="1">MSGVHGGNGKAVAKGPLVSKRVRDIFVTINMAILSQIISVFGVVANIINIAVFMKQGFGEAMTVTLTGLAVADLGTVTCQVWLSICWNPWFDFERLKLQFRPLHIEYLSAGHPRLSSVRVSAWILALATFERCLCITIPFKVREIITPYRARVFVIVVFAVNTACAVPFYYTSRIVQFFDSSANRSYLILSFTDDRQQIDSVFFAFSVSLTVISFVAVALCTIVLVYSLDKASQWRESVKTSNETKEEFKKTNRSAAKKDHGKTTQLNKNKRAAKMVSLISTIFIVCSLPNTVNQLVMSMVPEYAKNGAYNNINQMFWSLGYMFETVNASINIFMYYFMSTRYRTTIQELFGACCFCMDGADNVGKETEGNQTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433THX9</accession>
    <name>A0A433THX9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_011125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000354">
        <property type="protein sequence ID" value="RUS81139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433THX9"/>
    <dbReference type="OrthoDB" id="6146674at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019291664" description="C-type lectin domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="301"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="253"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS81139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="429" mass="46007" checksum="C8D454D2C8EABB1F" modified="2019-05-08" version="1">MCVHRAILLLALGMMSATVADPILDTNKAIKLSYVSNEHCLTITCNFEQTSSSLTQVGKLEIAITPLIGDGIFNPLTAIETSSQGQKLYNSLSESDLDLSGEIGESGNTESHLKLDWKTVTSGYCLIYKCSATGVDAQGNEVELFRSIKVKGRGGESCAVKPSFNEILNNLLTDSYTCSSTVERARHGLIQHRIDSLRGTVDGLAQLETSVDQNTQQIALLNSEISLFDSISSLTVVNTNSLTDAENQVSLLATKLTNDESETENLLNDLEARVNQASQQAILQYKLAKQVDSGNSISPVYEGRIYALATSTTNFTLVSANDMCKLYGGYLVELDGGSGEQSAVGNFLLSAGVTSAFTGGNDVDSESTFRYINSGTLFVNEMWAQFEPALAGRGAADDCVTIGQDGTLSEEECSGAGKYVCEIPLEFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TJM9</accession>
    <name>A0A433TJM9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_010533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000323">
        <property type="protein sequence ID" value="RUS81726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TJM9"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS81726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="147" mass="16165" checksum="9C8B1E99BB54ED91" modified="2019-05-08" version="1" fragment="single">MLAWLVGWLVAWLFGWLVIWLDARVVGYLRGWLVAWLVSCLASCLASSLVNCSVVLLVFVVVLMVMVVQVVVMVVMVVLVVEVVVVMLMMVVLVVVVMVVMLLIMVVLVVVVLVVQVLLEVVVVVPVVVVVMMVTIILLTVVVTIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TKG1</accession>
    <name>A0A433TKG1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_010190</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in signal transduction through the Wnt pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000307">
        <property type="protein sequence ID" value="RUS82034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TKG1"/>
    <dbReference type="STRING" id="188477.A0A433TKG1"/>
    <dbReference type="OrthoDB" id="270215at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15637">
        <property type="entry name" value="PHD_dPYGO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000107">
        <property type="entry name" value="pygopus homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052475">
        <property type="entry name" value="Wnt_Signal_Transd_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23194:SF16">
        <property type="entry name" value="PROTEIN PYGOPUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23194">
        <property type="entry name" value="PYGOPUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0879">Wnt signaling pathway</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="109"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS82034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="177" mass="19408" checksum="3A7CB1E8E8E7987A" modified="2019-05-08" version="1">MRIPHMEEKPKKSSDQQKNTLAELLPGPSPPPPVSTSNSSVIAQNPFDDPMPANALQSIPNTQTSMVSSQAGNMPQAMQHGGGMNPLSKVYPPNQPMVFNPSNPSAPPIYPCGICHKEVHENDQAVLCESGCNFWFHRMCAGLTHDAFSMLKVEVYAEWVCDRCLNTKNIPLVKLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TKV8</accession>
    <name>A0A433TKV8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_010013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000296">
        <property type="protein sequence ID" value="RUS82237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TKV8"/>
    <dbReference type="STRING" id="188477.A0A433TKV8"/>
    <dbReference type="OrthoDB" id="10256523at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="592"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="649"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="733"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="438"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="608"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="649"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="676"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="776"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS82237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="787" mass="89707" checksum="73FD1ACFB51A2392" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TN71</accession>
    <name>A0A433TN71_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HECT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_009202</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000261">
        <property type="protein sequence ID" value="RUS83014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TN71"/>
    <dbReference type="STRING" id="188477.A0A433TN71"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004939">
        <property type="entry name" value="APC_su10/DOC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042469">
        <property type="entry name" value="HECTD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46654">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46654:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03256">
        <property type="entry name" value="ANAPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01337">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51284">
        <property type="entry name" value="DOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DOC" evidence="4">
        <location>
            <begin position="207"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="3">
        <location>
            <begin position="530"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="2">
        <location>
            <position position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS83014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="854" mass="97276" checksum="B8DC70574399AEF7" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TPK7</accession>
    <name>A0A433TPK7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_008747</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000241">
        <property type="protein sequence ID" value="RUS83497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TPK7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019494589" evidence="3">
        <location>
            <begin position="26"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS83497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="491" mass="52088" checksum="42EFA1FC044AAB38" modified="2019-05-08" version="1">MASLSCRSVISVLLIHITIYLYAYAVGANNDTVITSIPTPINQQTTVNVTAKSTTDVGLQKTTDGQIKTDINTVLPTTVASTIENTTNNDFYSNSTTDVIPDQNSIETTTIKVSLQPSIDPVTDTGLQLNSTGELKTTLNPQLPTNNIEPQNNISDSSTSNNTSNNTTNPFISNNKSSTSNSTELTTPSGVNVLTAENKTATAASDDPPTSTPQFLPATTGLLTNSSASFLDTTEKTSPQPTEADNSTKTTNDTSESSQNTTIFQPTTNALVSSTGGPLLNTTEYSSFEDADNYTIMGNSTYEIVNSTDSPTTNPAKYENVSTNAAEEPTAQPEVSTKLTAKPETKPDTKPETKPETTPEPANNNDGEDGAMANSKSATTSGLQGDDVTIIIVLVCVGALIISIAVAIVYRRRQNRYAVELPILLDDTPRSSQGNQLHLWDYDESKSVPQSSSGQFSLDGPQANQDTPPNGLGDTSTLQIDSPKLNSFRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TQ22</accession>
    <name>A0A433TQ22_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospholipase B1, membrane-associated</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Lysophospholipase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Phospholipase A2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Phospholipase B/lipase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Triacylglycerol lipase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="43" type="ORF">EGW08_008588</name>
    </gene>
    <organism evidence="43 44">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="43 44" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="43">EC2010</strain>
            <tissue evidence="43">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Calcium-independent membrane-associated phospholipase that catalyzes complete diacylation of phospholipids by hydrolyzing both sn-1 and sn-2 fatty acyl chains attached to the glycerol backbone (phospholipase B activity). Has dual phospholipase and lysophospholipase activities toward diacylphospholipids. Preferentially cleaves sn-2 ester bonds over sn-1 bonds. Acts as a lipase toward glycerolipid substrates. Hydrolyzes fatty acyl chains of diacylglycerols with preference for the sn-2 position and of triacylglycerols with not positional selectivity. May also hydrolyze long chain retinyl esters such as retinyl palmitate. May contribute to digestion of dietary phospholipids, glycerolipids and retinoids, facilitating lipid absorption at the brush border.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = di-(9Z)-octadecenoylglycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38575"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:53753"/>
            <dbReference type="ChEBI" id="CHEBI:75945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="32">
            <dbReference type="Rhea" id="RHEA:38576"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40923"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28610"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:74669"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:40924"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="40">
            <text>1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2 H2O = sn-glycerol 3-phosphocholine + 2 hexadecanoate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:40975"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:72999"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="40">
            <dbReference type="Rhea" id="RHEA:40976"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41223"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:72999"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:41224"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="41">
            <text>1,3-di-(9Z-octadecenoyl)-glycerol + H2O = 1-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:39939"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75342"/>
            <dbReference type="ChEBI" id="CHEBI:75735"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="41">
            <dbReference type="Rhea" id="RHEA:39940"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="37">
            <text>1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O = 1,3-dihexadecanoylglycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40983"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75688"/>
            <dbReference type="ChEBI" id="CHEBI:77619"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="37">
            <dbReference type="Rhea" id="RHEA:40984"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O = 1-hexadecanoyl-2-(9Z-octadecenoyl)-glycerol + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40979"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:75585"/>
            <dbReference type="ChEBI" id="CHEBI:75688"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:40980"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>1-(9Z-octadecenoyl)-glycerol + H2O = glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38487"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75342"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:38488"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="38">
            <text>1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40915"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:34112"/>
            <dbReference type="ChEBI" id="CHEBI:64496"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="38">
            <dbReference type="Rhea" id="RHEA:40916"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41111"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:75466"/>
            <dbReference type="ChEBI" id="CHEBI:77623"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:41112"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="39">
            <text>1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O = 1-hexadecanoyl-3-octadecanoyl-sn-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41103"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:77623"/>
            <dbReference type="ChEBI" id="CHEBI:77624"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="39">
            <dbReference type="Rhea" id="RHEA:41104"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-3-octadecanoyl-sn-glycerol + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41107"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:75558"/>
            <dbReference type="ChEBI" id="CHEBI:77623"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:41108"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40811"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:73002"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:40812"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40971"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73002"/>
            <dbReference type="ChEBI" id="CHEBI:76084"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:40972"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40919"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:72841"/>
            <dbReference type="ChEBI" id="CHEBI:75158"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:40920"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="36">
            <text>1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38779"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:73001"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="36">
            <dbReference type="Rhea" id="RHEA:38780"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40911"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:73004"/>
            <dbReference type="ChEBI" id="CHEBI:73007"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="34">
            <dbReference type="Rhea" id="RHEA:40912"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="35">
            <text>1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40435"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="35">
            <dbReference type="Rhea" id="RHEA:40436"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + H2O = 1-octadecanoyl-sn-glycerol + (9Z,12Z)-octadecadienoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40927"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:75550"/>
            <dbReference type="ChEBI" id="CHEBI:77097"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:40928"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = 3-(9Z-octadecenoyl)-sn-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75824"/>
            <dbReference type="ChEBI" id="CHEBI:75938"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:42605"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="42">
            <text>2-(9Z-octadecenoyl)-glycerol + H2O = glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38491"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:73990"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="42">
            <dbReference type="Rhea" id="RHEA:38492"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:15802"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36231"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:30909"/>
            <dbReference type="ChEBI" id="CHEBI:36702"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:36232"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="33">
            <dbReference type="Rhea" id="RHEA:15178"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:12045"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 'GDSL' lipolytic enzyme family. Phospholipase B1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="43">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000236">
        <property type="protein sequence ID" value="RUS83620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TQ22"/>
    <dbReference type="STRING" id="188477.A0A433TQ22"/>
    <dbReference type="OrthoDB" id="10265800at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01824">
        <property type="entry name" value="Phospholipase_B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1110:FF:000005">
        <property type="entry name" value="Phospholipase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035547">
        <property type="entry name" value="Phospholipase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038885">
        <property type="entry name" value="PLB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325:SF31">
        <property type="entry name" value="GH22081P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325">
        <property type="entry name" value="PHOSPHOLIPASE B, PLB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="44" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00033022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00045916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00048015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00048049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00048227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00048362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00048374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00048386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00048454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00048613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00048656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="ARBA" id="ARBA00048699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="ARBA" id="ARBA00048869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="ARBA" id="ARBA00048872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="39">
        <source>
            <dbReference type="ARBA" id="ARBA00048939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="40">
        <source>
            <dbReference type="ARBA" id="ARBA00049363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="41">
        <source>
            <dbReference type="ARBA" id="ARBA00049372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="42">
        <source>
            <dbReference type="ARBA" id="ARBA00049461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="43">
        <source>
            <dbReference type="EMBL" id="RUS83620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="44">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="444" mass="49886" checksum="6E604DE0D22DDA39" modified="2019-05-08" version="1">MRKGEGSDVREPLVRREREMGFAAQMQVMPQAYPIPASTLTGRTLGQTRCPLVGFRRRRGHTLNETGKPKRILDEAMRNETWVTLMSEDQRIQDSETRKLGVFPCPGLPPSDPVPTSVHRLRPSDIKVVAAIGDSYSTARAGGGISPINMLFDYRGNSWSIGGDQDYDFHTSMPNILREYNANLYGYSKSIGDCQRNLNEAIIGARSRGFANQATSLVTKLKQDPNVDFENDWKLITVFLGGNDLCVYCLFDLTAAAYTRNLRRGLDILYANIPRAFINLVVVMHVGLTQTLHNGLISTIMLRLACPCGAFPKSQEANTKLGEYTEAYQQAVLDLAASGLYDTDNFTVVAQPFYQNITIPYKDNGELDYSFFAIDRFHISKRGHSVSGRSLWNNMFEPVGNKTTQVDWYDTEIVCPTEEFPFLFTNQNSDVADYAPYRMKLNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TVY4</accession>
    <name>A0A433TVY4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein AAR2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">AAR2 splicing factor homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_006535</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with PRPF8 (via RNase H homology domain). Component of a U5 snRNP complex that contains PRPF8.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000161">
        <property type="protein sequence ID" value="RUS85741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TVY4"/>
    <dbReference type="STRING" id="188477.A0A433TVY4"/>
    <dbReference type="OrthoDB" id="201752at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13778">
        <property type="entry name" value="Aar2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13777">
        <property type="entry name" value="Aar2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.550:FF:000001">
        <property type="entry name" value="AAR2 splicing factor homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.20:FF:000001">
        <property type="entry name" value="protein AAR2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.550">
        <property type="entry name" value="Aar2, C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007946">
        <property type="entry name" value="AAR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033648">
        <property type="entry name" value="AAR2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038514">
        <property type="entry name" value="AAR2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033647">
        <property type="entry name" value="Aar2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038516">
        <property type="entry name" value="AAR2_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689">
        <property type="entry name" value="A1 CISTRON SPLICING FACTOR AAR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689:SF4">
        <property type="entry name" value="PROTEIN AAR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05282">
        <property type="entry name" value="AAR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20981">
        <property type="entry name" value="AAR2_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="AAR2 N-terminal" evidence="10">
        <location>
            <begin position="12"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="AAR2 C-terminal" evidence="9">
        <location>
            <begin position="199"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS85741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="366" mass="42103" checksum="46F8A0B6AF765D90" modified="2019-05-08" version="1">MDQENAQKLFEQGAMFVLHDFPERSEFGVDYMSWNTGPNFKGLKMIPAGIHFIYYSSVNTEGERGPRSGFFYNFSPQEIVVRHWDVQAEDIKSTPLDEGEMERYKSNRLELDTFLGPYPYEKYKQWISLSKHISAELVNLLQPESGIIYSVPQFESASSTTQSRQAAVEAKQVENKDSKPKVSQSLPKLITVESSKIKYSDVPKKKFPPGATPAEISKYNLDSSYALDVLLTRYNKDFDKLLGEIQFAFLCFLIGQDFDSFEQWKKLVHLVCTSSEAIKVYSESYLALISVLHFQIREIPSDFFVDIVTCNNFLTSTLYELFQNIAGENANKKLQKKSKDFEKHLTEKFKWDFSSEPDEYAPVIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TX76</accession>
    <name>A0A433TX76_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_006035</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000147">
        <property type="protein sequence ID" value="RUS86189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TX76"/>
    <dbReference type="STRING" id="188477.A0A433TX76"/>
    <dbReference type="OrthoDB" id="9873027at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001397">
        <property type="entry name" value="Datilografo, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000322">
        <property type="entry name" value="GDNF-inducible zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000045">
        <property type="entry name" value="ZFP69 zinc finger protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000557">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000744">
        <property type="entry name" value="zinc finger E-box-binding homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000097">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001049">
        <property type="entry name" value="zinc finger protein 319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF53">
        <property type="entry name" value="CHORION TRANSCRIPTION FACTOR CF2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="344"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="372"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="400"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="428"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="456"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="484"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="512"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="540"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="568"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="596"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="153"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="235"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS86189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="626" mass="70185" checksum="3F20AB343152BB07" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U002</accession>
    <name>A0A433U002_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_005079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000118">
        <property type="protein sequence ID" value="RUS87147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U002"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS87147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="224" mass="26653" checksum="919A31FAD0409255" modified="2019-05-08" version="1">MDRFPTAEAELPLYHYAIRHIHREKTRVGRTAALSLRYSPHSPRKDTRGQNCRSIITLFATFTEKRHAWAELPLYHYAIRHIHREKTRVGRTAALSLRYSPHSPRKDTRGQNCRSIITLFATFTEKRHEWAELPLYHYAIRHIHREKTRGQNCRSIITLFATFTEKRHAWAELPLYHYAIRHIHREKTRVGRTAALSLRYSPHSPRKDTRDWRLSPSPCRRGHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U4H3</accession>
    <name>A0A433U4H3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6451 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_003516</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000075">
        <property type="protein sequence ID" value="RUS88701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U4H3"/>
    <dbReference type="STRING" id="188477.A0A433U4H3"/>
    <dbReference type="OrthoDB" id="6242193at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045609">
        <property type="entry name" value="DUF6451"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF25">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20049">
        <property type="entry name" value="DUF6451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6451" evidence="2">
        <location>
            <begin position="297"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="140"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS88701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="457" mass="53737" checksum="9B0C2ECAA84A96E1" modified="2019-05-08" version="1">MQTARAQTTQNQIDHITIDRKWRRSLQDVRAKRGADAASDHQLVIAVLKLKLKAYRDQADRPAHRFNVQHLKNKAKAEEYKVELKNRFEALSELDDETVENHWQEIKKTWNTACQQVLGKRTRELKEWISPDSWNLIKERKEAKQKINHTQDQARKEELQGQYRELNQKVKRSTKQDKKNFIHELTEEAETAAGKGDMKRLYNITRTLSGKNRSTPCPVKDKDGKAITCEAKQKERWAEHFKEILNRPPPPEPPEVPDAEGKNIKEVDKFTYLGSVVDKHGGIEEDIKSRTNKARFAFNSLRPIWNSSALSIRNKLRIFNTNVKSVLLYGSETWRTTKTNTTKLQTFINRCLKYILKVRWPQTISNEELWRRSEQTPIDIQIKKRKWVWIGHTLRKPSTDITRQSLEWNPQGKRKVGRPKQTWRRSMEAEIRSAGKTWTELKRDAQNRVRWRGVALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U5P2</accession>
    <name>A0A433U5P2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_003041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000063">
        <property type="protein sequence ID" value="RUS89162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U5P2"/>
    <dbReference type="STRING" id="188477.A0A433U5P2"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS89162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="213" mass="22197" checksum="E97F58765312549C" modified="2019-05-08" version="1">MVLKISICATANSLHLVAASNGAIANSLHLVAAILKISNCAIANSLHLVAAILKISICTIANSLHLVAAILKISICAIANSLHLVAAILKISICARANSLHLVAAILKISICAIANSLHLVAAILKISICAIANSLHLVAAILKISICARANSLHLVAAVLKISICARANSLHLVAAILKISICARANSLHFAAVVLKIFLMRKGFQKMLINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U6G6</accession>
    <name>A0A433U6G6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_002952</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000060">
        <property type="protein sequence ID" value="RUS89278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U6G6"/>
    <dbReference type="STRING" id="188477.A0A433U6G6"/>
    <dbReference type="OrthoDB" id="8065060at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF296">
        <property type="entry name" value="DEGENERIN-LIKE PROTEIN DEL-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 11" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="9 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS89278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="506" mass="57420" checksum="875D6312FABADBA4" modified="2019-05-08" version="1" fragment="single">MVVSGYALLPTQLRKKEMSKLTTRLNGRDLHPPATDYGTLQYHKGPSPAVLPITQLDAGSQTDPYLLEPVPGEQRYQQVGSLSADINDIIYSFRSVTTIHGVQHAAAARNRSFRRRVWAILVSLMAIFLTWFLCQQVSALSEHQISTTTTFDLRETMEFPAVTLCNLNQYNKNRVPDNFTIKAVIFYMSEYSRVARELDPDFAEPDLSKVKDVSGEELLEAATQAAPTIREFLVRCRWKGVLYNCSDLFHPSHTPQGWCYTFDMLLNQPIQTARVGEWAGLEVMLNIQQQDSYYSDELQAGIKVVVHRSGDNPFPKRYGWHVRPGVFASVALTQHNRMGLPKPYKAYKNRHCEDTNSPHFVNPLKRYSRYTAANCLEECSVNRMVSLCGCRAFNDAGNDTICSSRELLICYIPNKFNQTAAALAENGTSTLDNCDCPEECDMVTYTAALSYADFSSRFEQLQLRKTKIYPNIKDLRSSFINLRIFFETMSVDTLRQEPAVSILDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U8Z3</accession>
    <name>A0A433U8Z3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_001902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000035">
        <property type="protein sequence ID" value="RUS90304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U8Z3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS90304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="207" mass="21829" checksum="7BAADABF7FB6E19C" modified="2019-05-08" version="1" fragment="single">MMMKAAEMAGTGNLPGNSGHAGPIFTQEQLLERAKNLRALSEMAAGRGPRISAPQGVIPSIPAQTTASPKTSGIEDLSVQRKRKSEGEELRAAKKRQEMLEAEESRQRVERERIQRMQEQQQLKEKLAQEGMGDVTVVLPDAPPMEATDLSTSAPATLAAATTSGSSGTPGPSSSSSSMAVDKTTTLSLIRDNMNIQAPPPPPAGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U9B5</accession>
    <name>A0A433U9B5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_001812</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000033">
        <property type="protein sequence ID" value="RUS90407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U9B5"/>
    <dbReference type="STRING" id="188477.A0A433U9B5"/>
    <dbReference type="OrthoDB" id="6514358at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052129">
        <property type="entry name" value="Spermadhesin-Link_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46908:SF8">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46908">
        <property type="entry name" value="CUBILIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUB" evidence="3">
        <location>
            <begin position="143"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS90407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="178" mass="18638" checksum="429D3B59FEF21CE5" modified="2019-05-08" version="1">MLVVVSNLAAGELFNASFTSVPAGCDTLTSATSGSRTFSASSSVLINQTCSWTVAPVQTTGTAVISLSSVNLRADESLTVSSGVDGSGQVLAQFTGPHYLQGAPLPQVYVPATQRFRVSYTRLAAGSPFTGAVVQYSTLPEVCGGRLSQPKGSLQTPNYPNQYPINAKCEWTFSSRCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UBS1</accession>
    <name>A0A433UBS1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_000958</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000015">
        <property type="protein sequence ID" value="RUS91246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UBS1"/>
    <dbReference type="STRING" id="188477.A0A433UBS1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="42"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS91246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="149" mass="16282" checksum="B87F2F589AFE3300" modified="2019-05-08" version="1" fragment="single">MHSGGCVSNENRKSYTCVCHYPYTGQHCEIMLRTSPEPTTPEPTTTTTTPTTTTTTTTTTTTTTTATPTTTTTTTTTTTPTTTTEPLEKEQRIPKENLTDWAARDTLGNSPLHTAAKTLDAEETTTSAEHRQNNLFQSDAGRFETSRQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UD65</accession>
    <name>A0A433UD65_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_000489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000006">
        <property type="protein sequence ID" value="RUS91781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UD65"/>
    <dbReference type="STRING" id="188477.A0A433UD65"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2850">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS91781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="233" mass="26814" checksum="D355F92EE154192E" modified="2019-05-08" version="1">MWRRGVEGWGVELSGWGEHGSDLKGPINMCLYECEESERWVIEGVEYREPSEAELQPVPPGSVRGVPSSDSPLLVPVLCLRRALVTHVQRLGLVSVIAVPTGHAVREEEEEGEEKEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEKEKMVKKMKMKKKTLEEGSCFAAVWPNIFALDSGQYYTYRSDTNTGRVLLQFDPRSSHWTPDSITHTDLTQTQVSEILASKYFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UDB6</accession>
    <name>A0A433UDB6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EGW08_000472</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">EC2010</strain>
            <tissue evidence="15">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000006">
        <property type="protein sequence ID" value="RUS91764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UDB6"/>
    <dbReference type="STRING" id="188477.A0A433UDB6"/>
    <dbReference type="OrthoDB" id="2132067at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000405">
        <property type="entry name" value="Galanin_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF23">
        <property type="entry name" value="GALANIN-LIKE G-PROTEIN COUPLED RECEPTOR NPR-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00663">
        <property type="entry name" value="GALANINR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="213"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="62"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RUS91764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="346" mass="38807" checksum="DE7DB623DD8D0A6F" modified="2019-05-08" version="1" fragment="single">MAQDESQLSAHEPSTTPEVLDNMLPNSSLNRSAENSDILNNTLLQVLVPTIWGIIVVIGALGNTIVIFTMCRRGRGIPRTATNCYIINVALADLAFILIVVPLTTAAYVSDEWVYGEVMCKFQNYIIYVTLLSTCLTLTAMTIDRYFAIVHPIRSLRRRTPRVAAIICLAIWLTCLALCSPYLQVFALVQVESGPMELTVCKADWPQGWEKTVIVVVVMLTYVIPLFVIVVSYTLILRFLWRHRIGTRKGADSVRTTIANRRKKVAKMVAAVVVLFAITWLPIHLFNLCFVLLDDFPQSRPLYILKIFAHTLSYTGSCVNPFVYTIMGDGFRKAFRESLPVCANGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UDE4</accession>
    <name>A0A433UDE4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_000380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000005">
        <property type="protein sequence ID" value="RUS91809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UDE4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019123774" evidence="2">
        <location>
            <begin position="23"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS91809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="175" mass="19453" checksum="40CE295E36674B8A" modified="2019-05-08" version="1" fragment="single">MRPRAFLVLCVTWAVMYASVCSLSTQKKREGKRAQKYKQQPSGSPSSTRETTEAEADPQGNSPHTPSLQENILAVFGIRLPSNKGDNKQLSESRNSLHFTPEVTTSGDRDAVINSPAPKPNSMLDEGSGVDENVESTVRPSFVTEDDLKIQERQDRSYQYLQYLGNLVSAERFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UDH6</accession>
    <name>A0A433UDH6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_000446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000005">
        <property type="protein sequence ID" value="RUS91875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UDH6"/>
    <dbReference type="OrthoDB" id="6077660at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019213807" evidence="1">
        <location>
            <begin position="22"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS91875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="228" mass="25814" checksum="B4E98887BA0C0776" modified="2019-05-08" version="1">MGIRFLSLLLLPLTLEALAPADEFFDVLGTGLKEWRLVFRGTAFINKSMYKAYKDGSNVPAVVKNSCRQTDWTQPCDTHYRNTDALTHWNNVMEVLLGVVDRGQLVKTAVFKGDNSDYMNWFSESHYLNSSWPDLKPQHPHIYGITGDDGLQRRFFISHNYNGCMNDAGWVVVVDRLGVPCDWEKDEAFPIIKYAAGEKFENWNTGNFRNGDALVVFVKYSSGASIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-05-03" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UDR1</accession>
    <name>A0A433UDR1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_000300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000004">
        <property type="protein sequence ID" value="RUS91898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UDR1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS91898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="200" mass="22697" checksum="088AD7128AC743FF" modified="2019-05-08" version="1">MSWGIKAHSKIWPTFTMSWEEKAHSKIWPIFTMSWGEKGHSKIWPTFTMSWGEKGHSKIWPTFTMSWGEKGHSKIWPTFTMSWKEKGHSKIWPTFTMSWGEKGLSKIWPTLPSPGKRKVTVKYGPPSPCPGKRKVTVKYGPSSPCPGERKVTVKYGPPSPCPKKRKLTVKYGPPSPCPGKRKVTVKYGPPSPCPGRERSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z1U4</accession>
    <name>A0A3S0Z1U4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_023340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001938">
        <property type="protein sequence ID" value="RUS68899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z1U4"/>
    <dbReference type="STRING" id="188477.A0A3S0Z1U4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36162">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36162:SF12">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS68899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="355" mass="43651" checksum="88AFB0F3E0558FCF" modified="2019-04-10" version="1">MCCHTRDSNGTRINQDSDKRWPFLDMFLYSRDSQYVFGLNYVHLRKFTFKVEDVFPTQLMPFEGMLLWSMFVLIDQLWSMFVLIDQLWSMFVLIDQLWSMFVLIDQLWSMFVLIDQLWSMFVLIDQLWSMFVLIDQLWSMFVLIDQLWSMFVLIDQLWSMFVLIDQLWSMFVLIDQLWSMFVLIDQLWSMFVLIDQLWSMFVLIDQLWSMFVLIDQLWSMFVLIDQLWSMFVLIDQLWSMFVLIDQLWSMFVLIDQLWSMFVLIDQLWSMFVLIDQLWSMFVLIDQLWSMFVLIDQLWSMFVLIDQLWSMFVLIDQLWSMFVLIDQLWSMFVLIDQLWSMFVFIDQLWSMFVLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z8W9</accession>
    <name>A0A3S0Z8W9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RWD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_020184</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001121">
        <property type="protein sequence ID" value="RUS72055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z8W9"/>
    <dbReference type="STRING" id="188477.A0A3S0Z8W9"/>
    <dbReference type="OrthoDB" id="432311at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051246">
        <property type="term" value="P:regulation of protein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16470">
        <property type="entry name" value="RING-H2_RNF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23818">
        <property type="entry name" value="RWD_RNF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000215">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000050">
        <property type="entry name" value="eIF-2-alpha kinase GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039133">
        <property type="entry name" value="RNF25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13198:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13198">
        <property type="entry name" value="RING FINGER PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RWD" evidence="6">
        <location>
            <begin position="12"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="128"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="296"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="819"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1003"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1079"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1190"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="466"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="496"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="541"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="565"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="628"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="668"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="819"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="868"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="914"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="959"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1008"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1080"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1216"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS72055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1267" mass="143087" checksum="B6B02FF51C58FAF9" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZCB7</accession>
    <name>A0A3S0ZCB7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_016640</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000725">
        <property type="protein sequence ID" value="RUS75614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZCB7"/>
    <dbReference type="STRING" id="188477.A0A3S0ZCB7"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097272">
        <property type="term" value="P:ammonium homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000010">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730:SF6">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="10">
        <location>
            <begin position="19"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="461"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="465"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS75614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="509" mass="54938" checksum="7E52889F8C2983FC" modified="2019-04-10" version="1">MDNLETRLDSLETNMNIQFLVTMGTIVFLMQGGFALLEAGSVRSKNTSNILIKNLLDAFVSGIAYWIIGYALAYGDGNAFIGWTKWASDEVSRIELATFFFQYCFAATAATIVSGALAERCEFIAYFVYSFFITAFIYPVVTHWAWTDEGWLNKGYNYSIDGEYVVVSYSDFAGSGVLHCLSGVAALVGAAILGPRLGRYHSESGTVLPIRGHSVPFAALGGFILLFGFIAFNGGARSAIAGKEDGAVVSLAIVNTIISGSMGAFITLFIHRVGILGHTWSLLNTLNGSLAGMVAVCAGCNIIRPWAATITGTIGGIAFNITSWALTKLKVDDPLDAVAVHLGAGCWGVIAVAFLSYEKGIFYKWDKASGLFLGWQLIGLVSILAWTTVLCTIMFGALRLLGIFRVPEEIEKKGLDIPKHGEPAYPLESYGHGYMETILTMTDSGQLSNLKQGYPGYGNINKGMTPEEGHYESPEMKTMKHNASSVDFSPVSHPPSNGRPDGVQEQTQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZH26</accession>
    <name>A0A3S0ZH26_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_014779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000578">
        <property type="protein sequence ID" value="RUS77473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZH26"/>
    <dbReference type="OrthoDB" id="6160040at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS77473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="10458" checksum="8A29A8338190B18C" modified="2019-04-10" version="1" fragment="single">GRSEKDAGWAWVVLFASAASLFIFVVLSSSIGFFQVEIMEDLGVGSGPISIMSALALGQSSLLGPVSGLLSSLLSVRVTVYLGVSLYSGGLVLASFSQSLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZID7</accession>
    <name>A0A3S0ZID7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_013773</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000507">
        <property type="protein sequence ID" value="RUS78485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZID7"/>
    <dbReference type="STRING" id="188477.A0A3S0ZID7"/>
    <dbReference type="OrthoDB" id="10012075at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF253">
        <property type="entry name" value="DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="59"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="151"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="249"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS78485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="290" mass="32810" checksum="A8D6DA69BC1D22DA" modified="2019-04-10" version="1" fragment="single">MGNRRIISDDRITVERPFIVEWNLHLRKVMLSDAGTYECHINTSPVQLSPIQLVVQEPPRILESASSPVSMRVKEGETVQLLCNATGTPPPEVTWYKRPPGKDQVGIMNPGEVLVIHNASRTCAEVYQCRASNGVDPPAVRTISVHVEFQPEVVLPTKRIGQSLSRPTILECIISAYPHNVNRWRFNGSFISQSADRYSIELYKDGENQVTLTLRINSIRESDYGRYECYASNLLGEDSETMELYKYSREEKTVPTPTTTARPWIENPQNNFGTKDHQVSNRNGHSGYYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZIG4</accession>
    <name>A0A3S0ZIG4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_016662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000729">
        <property type="protein sequence ID" value="RUS75568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZIG4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS75568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="105" mass="12267" checksum="2671E73B1A3FF45E" modified="2019-04-10" version="1">MRKGLKDDEGYIFCILLLKFISFSQQTQHPFWIQPTCLKITTVTLSLPHSHTYTHFFYIFYLRCSFFFFTTSLYLSMFVCLSVCLSACLPACFLTFSSTPVRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZIS9</accession>
    <name>A0A3S0ZIS9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WDHD1 first WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_016495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000715">
        <property type="protein sequence ID" value="RUS75744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZIS9"/>
    <dbReference type="STRING" id="188477.A0A3S0ZIS9"/>
    <dbReference type="OrthoDB" id="427368at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057646">
        <property type="entry name" value="WD40_WDHD1_1st"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932:SF10">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24817">
        <property type="entry name" value="WD40_WDHD1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1 first WD40" evidence="2">
        <location>
            <begin position="2"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS75744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="126" mass="13686" checksum="421D5BF88328E655" modified="2019-04-10" version="1" fragment="single">SFILTGGSDGKVCIWEGKDDTDITTVTVGEKVYAVAFQGGRFFAATDENTIRIHTFPDGVGDGLVTRFTSPCRCFCITEDGSLLIAGADDFKIKVISMEENECICLYSEHQAPILSVSFDPSKEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZM53</accession>
    <name>A0A3S0ZM53_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_011290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000364">
        <property type="protein sequence ID" value="RUS80939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZM53"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS80939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="124" mass="14335" checksum="BB0435F1EC6DED91" modified="2019-04-10" version="1">MYKFQTLQATFSTIEYNNLFHNQHSGLLESWCLQLLTITAMYLSTMLPHFPYLPQHLDLRLIVYSTHTCSFCTTIICFADADRLALSCISTTKQILGEKKLDSPVLLNFNDKFNSIERCKAIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZNC7</accession>
    <name>A0A3S0ZNC7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_013297</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000480">
        <property type="protein sequence ID" value="RUS78956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZNC7"/>
    <dbReference type="STRING" id="188477.A0A3S0ZNC7"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972:SF65">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="232"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="52"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="191"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="307"/>
            <end position="314"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS78956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="562" mass="63850" checksum="FAC982A52CD71407" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZQ65</accession>
    <name>A0A3S0ZQ65_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_011997</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>oxaloacetate + acetyl-CoA + H2O = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the citrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000403">
        <property type="protein sequence ID" value="RUS80232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZQ65"/>
    <dbReference type="STRING" id="188477.A0A3S0ZQ65"/>
    <dbReference type="OrthoDB" id="8017587at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006101">
        <property type="term" value="P:citrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06105">
        <property type="entry name" value="ScCit1-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.580.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010109">
        <property type="entry name" value="Citrate_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01793">
        <property type="entry name" value="cit_synth_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007128">
        <property type="entry name" value="PRK09569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF8">
        <property type="entry name" value="CITRATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" evidence="8">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR610109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS80232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="468" mass="52008" checksum="925C126B887FB151" modified="2019-04-10" version="1">MSHAKTLGKLANGALKLQKCVLPATNHCRQASTSTNLKDVMEKIIPEKQKEVIEFRKKYGGAKVGEVTVDMMYGGMRGIRGLVTETSVLDPDEGIRFRGYSIPECQEKLPRAPGGEEPLPEGLFWLLLTGKIPTQEQVAAVTKEWNDRAGIPNHVITMLNNFPSKLHPMSQFSAAIAAMNSESKFAKAYAEGVHKSKYWELCYEDSMDLIAKLPTVAAIIYRNLYREGNPPDSIDKKKDWSWNYTSMLGFDDPKFVELMRLYLTIHTDHEGGNVSAHATHLVGSALSDPYLSFAAGMNGLAGPLHGLANQEVLVWTTKLQESLGGEVTDDQLRDFIWNTLKSGQVVPGYGHAVLRKTDPRYMCQREFALKHLPNDPLFKLVAQLYKVVPDILIEQGKAKNPWPNVDAHSGVLLQYYGLTEMNYYTVMFGVSRALGVLASLVWDRALGLPIERPKSFDTPGLKKLVGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZSF6</accession>
    <name>A0A3S0ZSF6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein fem-1 homolog C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_018098</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the fem-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000862">
        <property type="protein sequence ID" value="RUS74143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZSF6"/>
    <dbReference type="STRING" id="188477.A0A3S0ZSF6"/>
    <dbReference type="OrthoDB" id="4429489at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000104">
        <property type="entry name" value="Fem-1 homolog c (C.elegans)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000163">
        <property type="entry name" value="Fem-1 homolog c (C.elegans)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF85">
        <property type="entry name" value="PROTEIN FEM-1 HOMOLOG CG6966"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="128"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="161"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="508"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="554"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS74143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="665" mass="75310" checksum="1E7BE9692B4D9A62" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZTA5</accession>
    <name>A0A3S0ZTA5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dihydrofolate reductase</fullName>
            <ecNumber evidence="2">1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_017487</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15009"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="2"/>
    <dbReference type="EMBL" id="RQTK01000802">
        <property type="protein sequence ID" value="RUS74758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZTA5"/>
    <dbReference type="STRING" id="188477.A0A3S0ZTA5"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046452">
        <property type="term" value="P:dihydrofolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046655">
        <property type="term" value="P:folic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069:SF3">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00070">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHFR" evidence="7">
        <location>
            <begin position="6"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS74758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="189" mass="21736" checksum="E3FF56A79E9E73CC" modified="2019-04-10" version="1">MCKDSPIAAVVAICDGSRGIGKDGHLPWPYLREDHEFYMGLCKTTKDPAKKNGIIMGRNGWKKWKHKQHPNMAVVVTSESVPLDEPDCLGVARTFDEAIELLQTGPRSEEIETIYILGGRRNYDHSVSDPRCTTLYLTKVYKEFECDIFFPEYEHAFKKINHPTIQDHIRKDPTNGIEFRFEVHEKISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZUR7</accession>
    <name>A0A3S0ZUR7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_005914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000142">
        <property type="protein sequence ID" value="RUS86329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZUR7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS86329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="209" mass="23223" checksum="980A889FC5536F19" modified="2019-04-10" version="1">MYVRLCVPPSLPPFVIFHEAGRGPIIGRGVPGRARSCDKQSSSSRLVCSINTEPRTSRKQHHPQFSWSTFRKVCMLSKSQVTPVISSHISLGGVLSNVGPECLLQGKWVKPLVSIDLRPPYSRLTPPWAGDPLGETRPPGSSASQKPAARSTKDAELGLQMGEWRRWAGRTTQHQTQAHGPTDHQGYRFHGQTPALELPRWYIRNTTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZX21</accession>
    <name>A0A3S0ZX21_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CABIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_007068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000179">
        <property type="protein sequence ID" value="RUS85164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZX21"/>
    <dbReference type="STRING" id="188477.A0A3S0ZX21"/>
    <dbReference type="OrthoDB" id="9879477at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="776"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="856"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="964"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1001"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1134"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="806"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="964"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="975"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1024"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1057"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1079"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1134"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1154"/>
            <end position="1163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS85164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1163" mass="127936" checksum="25BE15FD2A74CC16" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZYZ2</accession>
    <name>A0A3S0ZYZ2_ELYCH</name>
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        <recommendedName>
            <fullName evidence="9">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_002102</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
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            <taxon>Mollusca</taxon>
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            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000039">
        <property type="protein sequence ID" value="RUS90135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="188477.A0A3S0ZYZ2"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01388">
        <property type="entry name" value="HMG-box_SoxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000002">
        <property type="entry name" value="transcription factor Sox-2"/>
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    </dbReference>
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        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022097">
        <property type="entry name" value="SOX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF231">
        <property type="entry name" value="TRANSCRIPTION FACTOR SOX-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12336">
        <property type="entry name" value="SOXp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3 7" id="KW-0238">DNA-binding</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="9">
        <location>
            <begin position="108"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="7">
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            <begin position="108"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <end position="110"/>
        </location>
    </feature>
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            <end position="348"/>
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            <end position="381"/>
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            <end position="424"/>
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            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS90135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="424" mass="46462" checksum="B85E40178FCD425F" modified="2019-04-10" version="1">MMMMEPADMKPPILHQPQQTQLPPLQPPSSQSGGGMHQGHHQMGGQQQHPQQTSPKGGSGHHHQQQQQHPGHTELPQTNHGGHGSPTNINNNNNNSANSKNNMDPSRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSEAEKRPFIDEAKRLRAIHMKEHPDYKYRPRRKTKTLMKKDKYALPGMPNPSSMSQVVRDPTGMYPPHMNYMSNGYAHMMGDPNAYSQMASGHLSGLNPAQYYPNFQAQAMQSQVNSGSYMNGPGGYNMSSMAAQMSPYAAHTMSPGPQGHGGQASIKREPGNGQQQQQGQGGNPVNGAAPAHTGPSKSPYPTPSAGQTGNEIREFISMYLPGQSEHGMSPGDQHSAHSAHSAHSAAFAAAQQRLQQMQQHYGVNGHHSHIPTSSDNSTVPLTHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZZV4</accession>
    <name>A0A3S0ZZV4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_001364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
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            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000023">
        <property type="protein sequence ID" value="RUS90857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZZV4"/>
    <dbReference type="OrthoDB" id="6157355at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018608436" evidence="1">
        <location>
            <begin position="26"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS90857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="515" mass="58146" checksum="DDBD1238053C8F68" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A0Z1</accession>
    <name>A0A3S1A0Z1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_001197</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000019">
        <property type="protein sequence ID" value="RUS91069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A0Z1"/>
    <dbReference type="STRING" id="188477.A0A3S1A0Z1"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF39">
        <property type="entry name" value="AMINOTRANSFERASE CLASS I_CLASSII DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="109"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS91069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="511" mass="58129" checksum="96638ECED123A712" modified="2019-04-10" version="1">MLCTRRVFGRQLMIQSKTGKKQFRSSLWLKLDRSYWTGHPFRSSGRMDSNSKPSTPHPDGATQDPSYDGLSDRALKAFSVSPAFNDYLSRTKHNKYHPETNPQGVVAFGLAENKVAVDVLQPKLEAIAARKEDPKIYSYGDTVGETGFRHSLKRFLEHNFHPLQELDINQLIVTNGVTVLLENLAFALASPGEYIMIPKPYYYRLILDFVERPGVNILPVEQPLPSDTKDNRYALDVPALEAAYLQAVREGKVVRAIHITNPSNPTGDIYTAQELRDLLDFAHRYNLHVIANELYGLSTYDPQVDFTSILSLPQPDPGRVHFLWGFSKDFGLSGIRISAMYTRHPGLLRFSRQTGIYIRPTEMGQNRLKHLIDDTDYIDTQALPEVRRRMWARHQSVKQQIEACGGRVHPSPATIFRWLDLSSFLTTPDLEGERDLFDRLYKAGVHLMSGESLGHSLPGWFRMVAALEDFAHTEGMNRLVSVLNEIRRERQQQNKTASRSSRDDISGMNVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A1L6</accession>
    <name>A0A3S1A1L6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_000682</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000009">
        <property type="protein sequence ID" value="RUS91567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A1L6"/>
    <dbReference type="STRING" id="188477.A0A3S1A1L6"/>
    <dbReference type="OrthoDB" id="2261376at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17317">
        <property type="entry name" value="MFS_SLC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="521"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="554"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="582"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="95"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS91567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="628" mass="69927" checksum="4AEFB5280FA5E8E2" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A403</accession>
    <name>A0A3S1A403_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_010030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000297">
        <property type="protein sequence ID" value="RUS82216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A403"/>
    <dbReference type="STRING" id="188477.A0A3S1A403"/>
    <dbReference type="OrthoDB" id="109543at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23802">
        <property type="entry name" value="UBCc_UBE2Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="32"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS82216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="194" mass="22022" checksum="1F2C66DFB52A84CA" modified="2019-04-10" version="1" fragment="single">YIVLLNFVSKLNRQEKEETLAASFTNSQGSKMAVKRLVKDLMQLNSSKTKSGIDASPSGNDLFIWNVKFTDIPTETKLGKDLQEYAKKYEEEAVICLQMLFPPDYPFSPPFIRILKPRFQFLTGHVTLGGSICMQMLTKSGWQPCNDIESILVQVRAEILSDPKASLADHETNISYSLEDAKIAFQRMTKKYGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A6X9</accession>
    <name>A0A3S1A6X9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_007994</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000212">
        <property type="protein sequence ID" value="RUS84242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A6X9"/>
    <dbReference type="STRING" id="188477.A0A3S1A6X9"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="87"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="187"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="220"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="253"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS84242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="383" mass="42399" checksum="27B8615A1A5A727E" modified="2019-04-10" version="1">MERCYCCQNQHQMSKDAVPSWSKGGQLSLAIQTCNKMWVQSLLSVPDQDFDIKKGNYICQASDKGDKDIMLELLAAGADPNEESSVCAKRPVHICAENGHLGAMEVLVRYGADINQLDAHKRTVMHFASQQGHGHSIEWLIDHGALADEIEMDGYSPLHVATCLGYKTACRSLLTLGKAEVNRLSKDSWSSLHMAASYGHPEIVKMLLSFGASHAQKTAEGETALHMACAKGFIDICQVLLDHGTHIESCNIHGATPLHYAVYYGHIQVVYRLLKSGASVNFLHLPAISCPVNISAMRGDQDMLDLLQCAGCVVRQDTAALLYQRKNISAQYRNSISRSPSLRDLCIWKVRLVLAPDLQNKTIFLPLPRVVKDVIMLHRLVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A9E9</accession>
    <name>A0A3S1A9E9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_006187</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000152">
        <property type="protein sequence ID" value="RUS86033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A9E9"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018750779" description="C-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="59"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS86033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="150" mass="17011" checksum="17DB0D7A77088D88" modified="2019-04-10" version="1" fragment="single">MGRTFCSTQLTITFLSLMTPSGGVPSEAETEKTLQALPCTAEKYSFPCERNFTELPEINKCLFFSTKALTRLEARLYCRWHEAHLVFIACAETDSAITHSSDFRNDSWVGIKACTESASWQEPNRKEPNYTNWETGPPERFCVVKSRLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AFL6</accession>
    <name>A0A3S1AFL6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_001679</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000029">
        <property type="protein sequence ID" value="RUS90591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AFL6"/>
    <dbReference type="STRING" id="188477.A0A3S1AFL6"/>
    <dbReference type="OrthoDB" id="9976881at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09401">
        <property type="entry name" value="LIM_TLP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21886">
        <property type="entry name" value="SARAH_RASSF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033614">
        <property type="entry name" value="RASSF1-6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011524">
        <property type="entry name" value="SARAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22738:SF15">
        <property type="entry name" value="LD40758P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22738">
        <property type="entry name" value="RASSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16517">
        <property type="entry name" value="Nore1-SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="3"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="7">
        <location>
            <begin position="205"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="140"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS90591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="46300" checksum="606C3FCC77923AC1" modified="2019-04-10" version="1">MNKNCAGCGKPVYFAERKTSLGREWHPSCLKCRECGKVLSPGQHAEYVNPLYLVLLTYINVLFCFLCRQEMLDKLAEFNKYYEGKVHHHMRAQQADDGSVFVEGPLRVYWGLSRPIQLAHCDNIPPAPISQWRHSLHVSADSPSLRRTGSPSRKSRDLDDLLSPSSSDDVVRRKKGGVRKFKTVAYRGGDQPSKWKRASINGHIFNFDTSVFTPVLGSCTSVTVDGTLNSLEVIETLLDKFKVQNSADEYVLSIVNEEGERLLTNRDRPLLERLKLGPDETVGKIFIKEREIIQEKGVGELVVSANVKASLLTGDKDSIDGGADGSPGYGRSIRSSSIKIPIRETEEEENLPHDVEQLLILPEPVLRGLLVKYHNDEELEVKKIRARYDVFRQRMTKRIYELLSNSTSSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AHB6</accession>
    <name>A0A3S1AHB6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNL-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_000088</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000001">
        <property type="protein sequence ID" value="RUS92235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AHB6"/>
    <dbReference type="STRING" id="188477.A0A3S1AHB6"/>
    <dbReference type="OrthoDB" id="512667at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024158">
        <property type="entry name" value="Mt_import_TIM15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007853">
        <property type="entry name" value="Znf_DNL-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922:SF13">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05180">
        <property type="entry name" value="zf-DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51501">
        <property type="entry name" value="ZF_DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNL-type" evidence="6">
        <location>
            <begin position="130"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS92235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="274" mass="31144" checksum="D1983EB419EC2936" modified="2019-04-10" version="1" fragment="single">TLQTAVFVGVYFLSCSVPFRVRWRRTRRIELRFIMSQIVKILRFSQSFRPLSRCASSVTHRWSRSTKSSCGNVNLCLLSVHQGLGQNVTKTSPILLTLTSSRQLTTSSVMFRPKRDYNKLENLRKKRLAEFQPKMGIIFKCKICGDRNAQSFSKKSYEEGVVIVKCNNCNNNHLIADNLGWFQDVEGRNIEEILASKGEKVLRASDTHLPQDLMEKIGEASSSSDGEEALTTAIPFEDVCLPVDQKAEKVEFSETERNMKIDGEKAKEPGRKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1ASI1</accession>
    <name>A0A3S1ASI1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">glutamate synthase (NADH)</fullName>
            <ecNumber evidence="19">1.4.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">EGW08_021360</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">EC2010</strain>
            <tissue evidence="22">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>2 L-glutamate + NAD(+) = L-glutamine + 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="1.4.1.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-glutamate biosynthesis via GLT pathway; L-glutamate from 2-oxoglutarate and L-glutamine (NAD(+) route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Energy metabolism; nitrogen metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Nitrogen metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the glutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.14" evidence="19"/>
    <dbReference type="EMBL" id="RQTK01001315">
        <property type="protein sequence ID" value="RUS70880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S1ASI1"/>
    <dbReference type="OrthoDB" id="4327079at2759"/>
    <dbReference type="UniPathway" id="UPA00045"/>
    <dbReference type="UniPathway" id="UPA00634">
        <property type="reaction ID" value="UER00690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016040">
        <property type="term" value="F:glutamate synthase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019676">
        <property type="term" value="P:ammonia assimilation cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097054">
        <property type="term" value="P:L-glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00982">
        <property type="entry name" value="gltB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00713">
        <property type="entry name" value="GltS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000031">
        <property type="entry name" value="Glutamate synthase 1 [NADH]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000043">
        <property type="entry name" value="Glutamate synthase 1 [NADH] chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000017">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000113">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.60:FF:000001">
        <property type="entry name" value="Glutamate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="entry name" value="Glutamate synthase, alpha subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006005">
        <property type="entry name" value="Glut_synth_ssu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051394">
        <property type="entry name" value="Glutamate_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01317">
        <property type="entry name" value="GOGAT_sm_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008730">
        <property type="entry name" value="PRK11750.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="Alpha subunit of glutamate synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0288">FMN</keyword>
    <keyword evidence="17" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="13" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="15" id="KW-0408">Iron</keyword>
    <keyword evidence="16" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="21">
        <location>
            <begin position="29"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="22">
        <location>
            <position position="1913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00024383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="RUS70880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1913" mass="211835" checksum="C05ABB98384AF5FF" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1ASQ3</accession>
    <name>A0A3S1ASQ3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sterile alpha motif domain-containing protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_021180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts promiscuously (via SAM domain) with EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3 and EPHB4 (via SAM domain) (in vitro).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001279">
        <property type="protein sequence ID" value="RUS71056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1ASQ3"/>
    <dbReference type="STRING" id="188477.A0A3S1ASQ3"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000055">
        <property type="entry name" value="Sterile alpha motif domain containing 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051725">
        <property type="entry name" value="SAM-SH3_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12301">
        <property type="entry name" value="SAM-DOMAIN, SH3 AND NUCLEAR LOCALIZATION SIGNALS PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12301:SF8">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="6">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="78"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00065890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00073398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS71056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="162" mass="17143" checksum="2F4B94C7F1192789" modified="2019-04-10" version="1" fragment="single">MATGSSSIVEDWLRSLGLVQYTQPFLDNGYDDLEVCKQIGEADLAAIGVCGGEHMEQLLGAVKVLREEGGAAVYFTLEESPRPTKPMPHGDARKFSGSPATAPSTPSGRGASGAAGASSLMRMDAYELGKSALVKFPSVQLKLILRDKLVENNIDLSGPPYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AZG5</accession>
    <name>A0A3S1AZG5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">snRNA-activating protein complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_020005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001094">
        <property type="protein sequence ID" value="RUS72232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AZG5"/>
    <dbReference type="STRING" id="188477.A0A3S1AZG5"/>
    <dbReference type="OrthoDB" id="20127at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019188">
        <property type="entry name" value="SNAPC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15131">
        <property type="entry name" value="SMALL NUCLEAR RNA ACTIVATING COMPLEX, POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15131:SF3">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09808">
        <property type="entry name" value="SNAPC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="354"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="537"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS72232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="660" mass="73499" checksum="83745E031A7FF8B5" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B181</accession>
    <name>A0A3S1B181_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_018578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000912">
        <property type="protein sequence ID" value="RUS73672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B181"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS73672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="482" mass="52845" checksum="B5C58F35333984AF" modified="2019-04-10" version="1">MEETFFVFAIQIIGALVLTKLDKARLIKLIVDSSGVRRQDILEVRPTRTRVTFAARPTNRTKAVADTTKNGPKRSHFGAFQTVLSLLTNKSVSMTPDRLAPPSSAPLPRPGGTRNTARTSTPGYIAPATIPPHIPGPRSGGPTWASRVSSRVPSPDHPAHSIRPEGQNNSPPLPSHPGVSRPDNARRSQQPNHTARANRPPLLPDPPLSRHLHPGHAKMTRASSYRLPRPAHRPPPVITPLASKETNSTPLPSLLDLKLSPPRNGPWPKEQNRKTKEKGERHNKKDMATNTEKQTTDADTETRTQTGQAMTREVYIQFKALHVHAALNDLIRCSPLKRITGELMLLQMHIQKASEEILYYTPPSRLRKIITKGPRADCDCLKDLESSLSCPPSELTPTPEIPPPTDADPISSPEASPPASPYPSSDEHDTSSAESTPPTSPRKSRPRARDPTPPPHVDREVFLERPTPGVVTRARAAKHSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B267</accession>
    <name>A0A3S1B267_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_017949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000847">
        <property type="protein sequence ID" value="RUS74274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B267"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS74274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="154" mass="17680" checksum="A9D4AD05C61E5BF5" modified="2019-04-10" version="1">MRRGMYNFVLHKVPRGYNQTNLFHNSFDQSLVHGYIFSGTVEKLELRVLMAKSKTQLLGLLSPFLLPYSADTRTLLWTFSHPLLLRLLILFYRIELSPHFPETLTLVALFLWCSPVLGTIPISWLICICLLFLGFIFHVELNALRATAGHGTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B329</accession>
    <name>A0A3S1B329_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_018388</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000894">
        <property type="protein sequence ID" value="RUS73844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B329"/>
    <dbReference type="STRING" id="188477.A0A3S1B329"/>
    <dbReference type="OrthoDB" id="6158692at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF18">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="54"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS73844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="364" mass="40780" checksum="F46110723389BB89" modified="2019-04-10" version="1">MSQLDLIAGLITGAQTAEPIQVQFDLDIPSRVFSFLMENISYWMVAVAMFGMTSNIFIIVTFAKMGFSESINISYCALCISDILCVATFTWNAICFIPAFVDLDLPFLPSEVVVITGGALSDTFSKTTAWITAFISLERCLCVVFPLRVKDIVGHRRTIFIVVTIFVLTILPLTSVTFYISVFDNKLDLDRNRTLVGVRYRTSALANVLYDMNFVYKLVFMNTAPLFIVLVCSVSMAVQLSRSAFWRLQQSGGAVSQDSGGESRAERKYLKDIRVAKTVLAIATCFIVLETLGTIKVLVSTTWQDFRPVGAYSRTFKLVSRLAFLLSLTNSSVNFVIYYNMGSRFRHTVKQLVVFNRQKPPTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B3V0</accession>
    <name>A0A3S1B3V0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein xylosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_020928</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001235">
        <property type="protein sequence ID" value="RUS71309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B3V0"/>
    <dbReference type="STRING" id="188477.A0A3S1B3V0"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008375">
        <property type="term" value="F:acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003406">
        <property type="entry name" value="Glyco_trans_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19297:SF185">
        <property type="entry name" value="BETA-1,3-GALACTOSYL-O-GLYCOSYL-GLYCOPROTEIN BETA-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19297">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 14 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02485">
        <property type="entry name" value="Branch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="63"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="86"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS71309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="400" mass="46169" checksum="5264F9EDF71EE7BF" modified="2019-04-10" version="1">MAFKLPHRAWWLKYMAILLALCTSLTYVQYTMQQPVWLGPISVVKSSIAFTVSDRTQFNVDKSGTSDKATVDNEDKYNINNLDDLDNSKENGKVDSDKNDKDDSNNSNKYDSHSKYEQKSDKDGKDNHSKVHTNGPDKKDKDKDNSYKGTSSDFKTNRTNQSNVKISKQNSSPATERPGFKLFSPAHSEIFQHKHFNCREMFAGNREEITRGVTVARIIAAQENNKTYDSTKPEIKNLIRVLETEGVNNRARDFRYLTPKWYLNATRNCSWFKQTRGYVTSALTQAEREFPIAFSMLVFKDVEMVERLLRAVYRPQNRYCIHVDAKADPEFFAAVQAVASCFRGSVRMSSRRVDVTWATFTVLEPELICMQDLWDMDGAHAQRKNRKWKYFINLTGQEFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B408</accession>
    <name>A0A3S1B408_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_017763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000827">
        <property type="protein sequence ID" value="RUS74488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B408"/>
    <dbReference type="STRING" id="188477.A0A3S1B408"/>
    <dbReference type="OrthoDB" id="6101731at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050672">
        <property type="entry name" value="FBXO45-Fsn/SPSB_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245:SF11">
        <property type="entry name" value="PROTEIN GUSTAVUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245">
        <property type="entry name" value="SPRY DOMAIN CONTAINING SOCS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="1">
        <location>
            <begin position="5"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS74488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="194" mass="21084" checksum="E2935C79362CF28F" modified="2019-04-10" version="1" fragment="single">SLSLSLSLSLTSGLREAVPMWIYTAKLPDDQSNHKFAAMSSGMQQLGPNTVARQRTGKFDTDAARWKEGFSSGEHVFEVVFPVAQRGVHASVGVGRDSVPLTINKSCSLSPGNFSVVSEIEFSTCSTPYSPLIDQVFLPDKFYMYLDADSGCLMFGSDHTYYGTAFDGIPTDQPLFPMVSAVTHGATITLFYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B7U2</accession>
    <name>A0A3S1B7U2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LITAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_014158</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CDIP1/LITAF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000534">
        <property type="protein sequence ID" value="RUS78078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B7U2"/>
    <dbReference type="OrthoDB" id="4713066at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006629">
        <property type="entry name" value="LITAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037519">
        <property type="entry name" value="LITAF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292:SF6">
        <property type="entry name" value="FI16602P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292">
        <property type="entry name" value="LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10601">
        <property type="entry name" value="zf-LITAF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00714">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51837">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="LITAF" evidence="9">
        <location>
            <begin position="16"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS78078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="103" mass="11455" checksum="C5C13E59E398BD47" modified="2019-04-10" version="1">MVPSGSVYYTQPTDGPALRVPVHGCLQIYGTHPALIQCQYCGQTVYTFPEPRAGALTILLSLLLVIWGCFLCCWIIPFWTNFGKDVEHRCPSCGYIVGVYKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B8M8</accession>
    <name>A0A3S1B8M8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_014534</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000559">
        <property type="protein sequence ID" value="RUS77698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S1B8M8"/>
    <dbReference type="OrthoDB" id="10038545at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047150">
        <property type="entry name" value="SGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831:SF2">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="88"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="88"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS77698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="340" mass="38412" checksum="87931C3F7AB3671C" modified="2019-04-10" version="1">MIHKLFYNGSCKDNLKKRKNKRKKKKKKKKKKKKKKKKKKKKKKKKKKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXEEEEEEEEEEEEEEEEEEEEEEEEEEEEAEDRLKNICPIVSLLGQNASTSLACPAPAAIPAPTPSPSAQAQYLQKLQESSEAIRAGNYRRAIQLYTESIGLDPENHILYTNRAAAHLKNGQPEKALEDSVRARSICPKWGKVQNPPLNRLAAVTSAVIWSARNYLIGSINIWPGSAVSPALSLGSLRPTQAVRYYMGLSTNQTVFISLSNGPNNILDFYLELIRCGGPSLHPDCCHDGEDEGVYESVMIRHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B8R7</accession>
    <name>A0A3S1B8R7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_009718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000283">
        <property type="protein sequence ID" value="RUS82504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="70"/>
        </location>
    </feature>
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</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
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                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
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                <person name="Li S."/>
                <person name="Pierce S.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <sequence length="298" mass="34183" checksum="FD67552E4D12F2AD" modified="2019-04-10" version="1">MNVRKEFISLKKVKVICPDGFPYHAYDAKGQVTPWSIIRMVDFSRNIAFSNSPTADPPQQSFLDVVRLTEEFLLFTAATSTSISPNLYDSGTKKGPLELHLELDNVGNTSYCIKTLFFLGDQDRPVIENETQMVMVDFNLKRPSPPPDWWREKYSAGGLETGKGLRLPRAVPPESGVLSHYQVKIAASDLDIYLHTNWANYLKFCYDAFVDYKFHQVHQVHQHGRESIQDAFRKTRRFALRFMHETSLGDALDVTLWKDSGNPDLYMFQVLKQAEDLCEAQVEFYPDEDDDDEVAPKN</sequence>
</entry>
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                <person name="Li Q."/>
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                <person name="Li J."/>
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                <person name="Li S."/>
                <person name="Pierce S.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="1">
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            <begin position="3"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
    <sequence length="206" mass="24540" checksum="9172A3B69CA8A3A6" modified="2019-04-10" version="1">MSENGMTYFLYGGALIGSYRHHGLVPWDDDVDVIMPFSHRLNLYRLLGSLHEDIIVSFHPVHYWKLYHKDGEVIRNVPWKYPFLDIFFYNKNETHIWDMAPQYKRSFVYPKYQIFPLRLRPFMGLSMFVPKDPKAVISKHYNISMCTSGGYAHRWERKIYSTTVPCSWMQPLFPFVERQTMHGGCNETLWYRDTLVGDFFDWGVSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BBX6</accession>
    <name>A0A3S1BBX6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="4 10">5.2.1.8</ecNumber>
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        <alternativeName>
            <fullName evidence="9 10">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_007603</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
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                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4 10"/>
    <dbReference type="EMBL" id="RQTK01000199">
        <property type="protein sequence ID" value="RUS84631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BBX6"/>
    <dbReference type="STRING" id="188477.A0A3S1BBX6"/>
    <dbReference type="OrthoDB" id="16120at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1150:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0697">Rotamase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="364"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="377"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS84631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="414" mass="46012" checksum="7ED408ACF65A7A3C" modified="2019-04-10" version="1">MASTFAVKLTSETESDALDLSTHVFMKPEKNLKSPDDMPKWKASQAYSNIVGFILTLNEAVKNKKIGDEYPVSEMVEKMVGLLSTVEGWIAETPAIEQPQRFGNKAFRQIYTRLLNKGPTLLEEMLPSELEPAVLELCTYLVESIGNDTRIDYGTGHELAFVAFMCCATRVGVFKEEDYPALVLRVFDKYLNLVRKLQLTYRMEPAGSQGVWSLDDFQFLPFLWGSSQLFDHPTIRPQSFPEEEIYNTFYKDYLFLAAIKYINMVKTGPFAEHSNQLWGISGVPGWKKVNSGLIKMYKAEVLGKYPVVQHFLFGSLLTMVDAPAWSHFSSMSTISSQPMSGFSTPKGSIVSPAPLPPNLGMAPWALPQAVGKPAPPQVQTTHLQTDRASPSQSQPASNTSPENLSPDSSSRGCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BDR4</accession>
    <name>A0A3S1BDR4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cryptochrome DASH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_011062</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May have a photoreceptor function.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </cofactor>
        <text evidence="7">Binds 1 5,10-methenyltetrahydrofolate (MTHF) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="5 7">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000351">
        <property type="protein sequence ID" value="RUS81197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BDR4"/>
    <dbReference type="STRING" id="188477.A0A3S1BDR4"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000719">
        <property type="term" value="P:photoreactive repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014133">
        <property type="entry name" value="Cry_DASH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02765">
        <property type="entry name" value="crypto_DASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF22">
        <property type="entry name" value="CRYPTOCHROME DASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00147">
        <property type="entry name" value="DNAPHOTLYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0157">Chromophore</keyword>
    <keyword evidence="3 5 7" id="KW-0274">FAD</keyword>
    <keyword evidence="2 5 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="8">
        <location>
            <begin position="7"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="283"/>
            <end position="290"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="6">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="6">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="6">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS81197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="471" mass="53772" checksum="3B46E97A2F777B7E" modified="2019-04-10" version="1">MGSQTYDLVICLFRNDLRIDDNEILELANQSKHVLPLYCFDPRHFSKTKLFGFPLSNGHQWKFLVECLTDLRKQFQSLGSDLVIRQGKPEEVISNLLKTLNLGPDVAVMFDKEVLGEDAEMENALKKSCEVTVEGTWGKMLYHIDDLPFAPKEVPDIFKNFEKALTDTCKIRKCFERPKQMKPLPEGVDPGTFPKPESFGIHAPEQDSKSQLAFVGGEMVALDHLQKFLWGHKGDKASSDMSGTRLSPWLSHGCLSPRKVFWAVKTYEKEQKTNPSTEKMTHELMWRDFFQYMAMKHKEKLFAPEGIKGEQVTWKHNMDHFNAWKDGKTGVPYIDANMRELAATGFMSNKGRENVASFLTKDLLLDWRLGAEWFEANLIDHEVCNNYGNWMCVAGVGLDPELSHKYNVVKEGLLHDCNGDYVRLWVPELDGIKSSKVHKTWCLEATDLKASKVELGKTYPKPIATAAEWTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BDZ5</accession>
    <name>A0A3S1BDZ5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_010842</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000339">
        <property type="protein sequence ID" value="RUS81404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BDZ5"/>
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    <dbReference type="OrthoDB" id="10267033at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.670:FF:000001">
        <property type="entry name" value="Exocyst complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.670">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.30">
        <property type="entry name" value="Exocyst complex subunit Sec15 C-terminal domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007225">
        <property type="entry name" value="EXOC6/Sec15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046361">
        <property type="entry name" value="EXOC6/Sec15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042045">
        <property type="entry name" value="EXOC6/Sec15_C_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048359">
        <property type="entry name" value="EXOC6_Sec15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042044">
        <property type="entry name" value="EXOC6PINT-1/Sec15/Tip20_C_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702">
        <property type="entry name" value="SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20651">
        <property type="entry name" value="EXOC6_Sec15_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04091">
        <property type="entry name" value="Sec15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025007">
        <property type="entry name" value="Sec15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC6/Sec15 N-terminal" evidence="7">
        <location>
            <begin position="71"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex subunit EXOC6/Sec15 C-terminal" evidence="6">
        <location>
            <begin position="472"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="256"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="399"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="418"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS81404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="861" mass="98949" checksum="A0533F008D09094D" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BGQ1</accession>
    <name>A0A3S1BGQ1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_011907</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000398">
        <property type="protein sequence ID" value="RUS80338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BGQ1"/>
    <dbReference type="STRING" id="188477.A0A3S1BGQ1"/>
    <dbReference type="OrthoDB" id="6089342at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050991">
        <property type="entry name" value="ECM_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708:SF2">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708">
        <property type="entry name" value="TENASCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018549241" description="Fibronectin type-III domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="310"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="430"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS80338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="746" mass="82249" checksum="945559CA6F7ABFB8" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BK07</accession>
    <name>A0A3S1BK07_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_006669</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000165">
        <property type="protein sequence ID" value="RUS85586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BK07"/>
    <dbReference type="STRING" id="188477.A0A3S1BK07"/>
    <dbReference type="OrthoDB" id="6107040at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000007">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Peptidase A2" evidence="9">
        <location>
            <begin position="127"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS85586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="417" mass="46736" checksum="7F135870A9CD7550" modified="2019-04-10" version="1">MIADGSSIPEEDVTSSRSQPETIQPLVESANSNTGLDTKNLGKGKMKRKRELGESYMGRQLDKRTKTYIPTERMQKVLGNSSSLPTWVQIFVLAAFGKRQRQPLSVATAGNPHQPNTFSVVDRLSGRSYLVDTGTEVSVYPASVQERKSQPPSSTLTAANGTSIRTWGKRKIFLAIGQKGQYQHEFYLADVTRPILGADFFIKHGLAIDLRGPPTHSRARRLHQAKLSAAKAEFLQMEDTGIIRLYKSTWSSPLHMVPKADGKWRPCGDYRRLNASTDDDRYPLPHIQDFNNHLAGCKVFSKIDLIRGYHQIPMAPSSIPKTAVVTPFGLWEFLRMPFGLKNAAQSFQRLMDGILRDIPFAFVYLDDILVASRSSQEHAQHLEQLFNSCLLTVLSSTRQNVSSVSRNLIFWDIMSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BK66</accession>
    <name>A0A3S1BK66_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_006593</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000163">
        <property type="protein sequence ID" value="RUS85647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BK66"/>
    <dbReference type="STRING" id="188477.A0A3S1BK66"/>
    <dbReference type="OrthoDB" id="6161279at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000116">
        <property type="entry name" value="Dachsous cadherin-related 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026">
        <property type="entry name" value="FAT ATYPICAL CADHERIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026:SF126">
        <property type="entry name" value="PROTOCADHERIN FAT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="76"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="181"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="286"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="391"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="496"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="601"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="709"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="815"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="948"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS85647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="948" mass="104032" checksum="B7F4B741AE66C381" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BKN3</accession>
    <name>A0A3S1BKN3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_006253</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000154">
        <property type="protein sequence ID" value="RUS85983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BKN3"/>
    <dbReference type="OrthoDB" id="6104821at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS85983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="301" mass="31361" checksum="05FB90D9D5A8821D" modified="2019-04-10" version="1">MTGTRHSRSNPRPAAAMLDGQVAVALTLLFCCLLMSGTGNTFAADVAVDVSNNSSLSVLVINVTDTPTDVCPEASCGGGCGGAVAGAVVASLIVGLVTGALATYLVQRYLKKRRRSIPPKDYTNTESSALDVNMNNGEGTARDSGDVSPPEDVPQVKGHKKLERLSKQGPKPIIGPKPVLGQKGKPNPHSGVQTPLIYLGPRNEKPDSRPSSAPSLAVQSEEGRRSAGLASLQQPSSSPAGDDEGGGSDDEADQGNVYQDVDYTNIGLDAALSQPYDSLDVIPEEVEYANTQEYEQLGLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BMZ7</accession>
    <name>A0A3S1BMZ7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="10">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_021418</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="10"/>
    <dbReference type="EMBL" id="RQTK01001328">
        <property type="protein sequence ID" value="RUS70818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BMZ7"/>
    <dbReference type="STRING" id="188477.A0A3S1BMZ7"/>
    <dbReference type="OrthoDB" id="15304at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19673">
        <property type="entry name" value="UBR-box_UBR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.30:FF:000002">
        <property type="entry name" value="Putative e3 ubiquitin-protein ligase ubr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF39">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="12">
        <location>
            <begin position="100"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="9">
        <location>
            <begin position="100"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS70818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1235" mass="139925" checksum="75FE569A3737D095" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BNI6</accession>
    <name>A0A3S1BNI6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UPAR/Ly6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_004433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000100">
        <property type="protein sequence ID" value="RUS87834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BNI6"/>
    <dbReference type="OrthoDB" id="6148423at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018652479" description="UPAR/Ly6 domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS87834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="19351" checksum="71A32A8930187C73" modified="2019-04-10" version="1">MNSWKVLGAVLLLSVFVEDALGFPKFEWMAHKLSENSADLLRQASKRSEQAKRFGGGDKDNDGQLKCYGCRNTDPDSSSCSGTVELCQTGEVCASIFHSDNTNLDGCLAATICSELAKAPGIYARCCSSDMCNMTLSCQRTPKTWTGVLKTPNQLSRGYGVEVVEAQIRPNVPGSKNVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BNN0</accession>
    <name>A0A3S1BNN0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphodiester glycosidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_007247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000186">
        <property type="protein sequence ID" value="RUS85002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BNN0"/>
    <dbReference type="STRING" id="188477.A0A3S1BNN0"/>
    <dbReference type="OrthoDB" id="192253at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033299">
        <property type="term" value="P:secretion of lysosomal enzymes"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018711">
        <property type="entry name" value="NAGPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40446">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40446:SF2">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09992">
        <property type="entry name" value="NAGPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphodiester glycosidase" evidence="1">
        <location>
            <begin position="157"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS85002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="383" mass="41204" checksum="E90B2CFF73F6FF8B" modified="2019-04-10" version="1" fragment="single">MTSTGSQPWARGISLPRRSPSLQCFALQCLWLAVMASLDGDLLYRLSGAESRYAPLSREHRDVKSCQRVLFENVTHTKHLAAGAGVTGPPSLPLVESHYFLDTVGQSYWDRKEVSVLHQVIPNPLTSLAVLEPGRPGSCDNGTDGRTLVRDTATLNDCILATNAGMFNTHTGACLGNVVSNGVLVQDSGGIQNAHFSLTKDGHIFTGYLSQLDLLTEDFTQLVGGVIWLVKDGASYVDHSLGVECPDTQETGSLERFTSVVSARTAIGHDVEGRVHLVEVNGKTDQKGINLYSLAEMLIRMGIVNAINLDGGGSTTTVINGTLVNYPSDQCQNSSYNCERPVTTVMCVHAPHCDPRDCSGHGSCDLGECRCRGFWHGPGCDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BNU5</accession>
    <name>A0A3S1BNU5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase/retrotransposon-derived protein RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_020894</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001229">
        <property type="protein sequence ID" value="RUS71351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BNU5"/>
    <dbReference type="STRING" id="188477.A0A3S1BNU5"/>
    <dbReference type="OrthoDB" id="6283403at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="2">
        <location>
            <begin position="138"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS71351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="269" mass="30169" checksum="2376F308187CB4CD" modified="2019-04-10" version="1">MTVMTKRDFDQYIAVPLAPSNKQLQTYTDQPVPILGECLVSVKCQAKQVDLPLIVVKGEGPPLLGRNWLQCLRLDWPSLFSLSDLSASAPPPICLEDVLNQNSEVFGESGLLKDRKVRLSIKSDSVPRLLRKGEKEQWAKEQEDAFHRDKEILSSKQVLVHFDASKKIILICDASPDEVGAFLSHEESSGSFGKSKPLPEHAAPRVQRWAITLAVAAYTYQLKYRPGSENNADAFSRLPLQQNTKEYVPEDIEMLFSVIDTAELMLMML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BRF0</accession>
    <name>A0A3S1BRF0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_002544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000049">
        <property type="protein sequence ID" value="RUS89726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BRF0"/>
    <dbReference type="OrthoDB" id="273230at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053325">
        <property type="entry name" value="H3-Acetyl_Activator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35706:SF1">
        <property type="entry name" value="EMBRYOGENESIS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35706">
        <property type="entry name" value="F14O23.11 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS89726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="115" mass="13407" checksum="F27E3D7D33C4E7F8" modified="2019-04-10" version="1">MQHLYQIRHISVSEKRLKQELSAADMKKAMDQLTEQFMEARELIEDARESMETVYFSDDMAEAQEAVTTTLDQYQKLLSQLSESQRQEVLRTIGLRMEELKAQEQALKDAVLDSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BSB5</accession>
    <name>A0A3S1BSB5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ceramide glucosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.80</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_002044</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.80" evidence="5"/>
    <dbReference type="EMBL" id="RQTK01000038">
        <property type="protein sequence ID" value="RUS90165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BSB5"/>
    <dbReference type="STRING" id="188477.A0A3S1BSB5"/>
    <dbReference type="OrthoDB" id="1483400at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008120">
        <property type="term" value="F:ceramide glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006679">
        <property type="term" value="P:glucosylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025993">
        <property type="entry name" value="Ceramide_glucosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726:SF0">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13506">
        <property type="entry name" value="Glyco_transf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS90165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="362" mass="40284" checksum="F28D4F24996A73F4" modified="2019-04-10" version="1">MITITDFCSQYELLFSVPDDYDPAILVVKSLIESYPKVDAKLFIGARDVGSNGKINNMVRPYEAAKFNNIVISDTGIKTTPTTLREMVSCLKPDVGLVLQMPYCAPRKGFGAVYQQVYFGTMQARNCLSANACNINCSTGMSCLLRREVLDQAGGLAPFGKYLAEDHFIAEGIRKQGYKVVLSTLPALQNSGNCGISDFHKRLVRWAKLRMTLLPTLILLEPLGESVIQGAAASLAAGYLLDISPLAFFIGHLLIWFLSDYILLRIVQNGPLPFSKFEFLAAWLFRETMAPYILIQGHMTTHVMWRDRKYRVKWGGEVERIPELGETIEDKVEKFSADSGNVATQRSSKKMVEVLNCVAVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BSV9</accession>
    <name>A0A3S1BSV9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_018140</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000866">
        <property type="protein sequence ID" value="RUS74093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BSV9"/>
    <dbReference type="STRING" id="188477.A0A3S1BSV9"/>
    <dbReference type="OrthoDB" id="6147321at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF199">
        <property type="entry name" value="IP13425P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="356"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="60"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS74093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="392" mass="44064" checksum="AD284117F9E9D0FE" modified="2019-04-10" version="1" fragment="single">MSSIPNATDEFPPLPTTDVYTVNVNQIYDTQDVFWSHTGHVLDQRHTTAIRIFSIFGAMVNLFVMAVCMTSKGLMSMRSTYLVISLSLADFLVCAGVMPLTNAMHHIPVQPIICSLWYAFASFACVTSSLNICAISIDRYVFITSPLRYDRKMSQTKLRLLLLAVWLTGAAVSALCFFLTYDVGIPFPWVRNFLHDHKDTRCAPNATTEWELQRNNCTGCHVYLGKEYNLSLIIFILFLPTIVIIVLYSRIYIVVRSQLKAIRRNAHRSFSTTAESPAPVPPAPRPSKLDLRPRSKSEIELRSIHRRSLSYEAAQFISDAFSSRNSFVFGQKVASNFSTKLDALASFITQEKKASFILGIVIGAYVLSWVPFGISVVLEVIYETPGNSKTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BUJ4</accession>
    <name>A0A3S1BUJ4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_003189</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000067">
        <property type="protein sequence ID" value="RUS89078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BUJ4"/>
    <dbReference type="STRING" id="188477.A0A3S1BUJ4"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000036">
        <property type="entry name" value="CYtochrome P450 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF375">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS89078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="509" mass="57389" checksum="C1289A453E7FB1F5" modified="2019-04-10" version="1">MLQPDHSTVLLAVAAILMGWCYFFLQRRKTGDHRRLPPCPVRPWPLVGNMFSLGEDIRAQFKAWHKQCGDIYCLYFGNTLLVVVNGFTTIKKVFVQNGAVSSDRPRVFFNEVAGMGQAGLGFATGATWKDNRSTSLQILREFGMGSTSNFLADTVRKETVCLVNKLVEKEGKTVDLLYFARVSMANVILSMLIGRRFSYEDPRFKNAVERMINVAESARGAGAINFLPFLKYLPGDMFDAKKIQVNLKPFADFLVEEIIELESNGCSKSDTVERSADNFISSYKRRQTEKLQSGKKTSLNYENMIKSALDLFAAGTETTSSTIIWCVLFILHSTDVQSKIHEELDREVGQGRQPTMEDQKNLPYLGAVIKETQRLASVLPFSVLHKTSKEIAIGDFVIPEGTTLMPSLDSVLHDPQIWGDDAEEFNPERFLDKDGNLIHREEFIPFFVGPRYCVGEAMAKMELFLFLSSMFQRFNFVAIDPENPPTLKPIIGVVSVPTPYKVLCVDRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BXF5</accession>
    <name>A0A3S1BXF5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_000966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000015">
        <property type="protein sequence ID" value="RUS91254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BXF5"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS91254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="187" mass="21337" checksum="D89DD002125BE51C" modified="2019-04-10" version="1" fragment="single">MRSYRDAANQDRENHIETPEEQEVHHHEKHKRGRSPRRRNVLANDAASNNRRVNSKELNASKEVEKASNSNNTRGHKENSNKLGSLVVVEEWDRGRAKKSKKSKKIVGINEALLSKANTHSNQAVASSLVDVDLDSNLMSQEAPAFQNKTSKDRETDYFVKFCDRVFDDPKVVPNICNRPYIEISNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BXH8</accession>
    <name>A0A3S1BXH8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_000916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000014">
        <property type="protein sequence ID" value="RUS91302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BXH8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS91302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="122" mass="13204" checksum="074B85A1BD7072FF" modified="2019-04-10" version="1">MPGTKDEVAVETPETTTEPIVAKTVEDVKAKTDAVEAEAEQKKEESEATESTENTNDNASTEEKSEESESKTEETETTAEKRSVEEETEEAEDESPKKKVKTDTTEAEESSNGTAEKAEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BYP1</accession>
    <name>A0A3S1BYP1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_000142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000002">
        <property type="protein sequence ID" value="RUS92118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BYP1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS92118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="147" mass="17187" checksum="E795E64AE84A31BF" modified="2019-04-10" version="1" fragment="single">TWYTCILVHISDSSRFQDFIINGKVASELATITGQNDISRITHHVSSSAVFLDLPSTSQHFHSCSPDSYFLITCSWPKSVDSYTIILELFRHSENTKRHSVLGHCICYRHIKLTYMTFEPFWIQVQWRADVEYMRIFGFKEMWQAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C4F2</accession>
    <name>A0A3S1C4F2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear pore complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_009543</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
            <location evidence="8">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the nucleoporin Nup84/Nup107 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000275">
        <property type="protein sequence ID" value="RUS82706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C4F2"/>
    <dbReference type="STRING" id="188477.A0A3S1C4F2"/>
    <dbReference type="OrthoDB" id="3098at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.190.50:FF:000001">
        <property type="entry name" value="Nuclear pore complex protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007252">
        <property type="entry name" value="Nup84/Nup107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003:SF2">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003">
        <property type="entry name" value="NUP107-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04121">
        <property type="entry name" value="Nup84_Nup100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6 8" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS82706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="554" mass="63752" checksum="50057F6CDFEBF63D" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C689</accession>
    <name>A0A3S1C689_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_008093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000217">
        <property type="protein sequence ID" value="RUS84119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C689"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018658741" description="VWFD domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS84119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="26925" checksum="0501EEF8A065D01F" modified="2019-04-10" version="1" fragment="single">MNGTVLVVSLALLVNLTLGAEVCDSRGRSCVSSSAECVNAKCVCKAPNVWGDGAFNCYRQNTVVSQVLNDPDLYNYNNESIAFPYPCRYMLTHLIQELKDDDRNIIGSCEIMVHSFNAKYRGKFFLHGFDVALSIRYDNGQKVKMSSRHYGVAKNGAYSFKSRGTIGQFWQNGPWQTDDIYYEDAANGIKVEVYQDTDNNQLIYEAKKCGIRATFVPYDIKDRRAQVSLPGMSFAVNCAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H4H2</accession>
    <name>A0A3S1H4H2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-keto-steroid reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_020215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001126">
        <property type="protein sequence ID" value="RUS72031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H4H2"/>
    <dbReference type="STRING" id="188477.A0A3S1H4H2"/>
    <dbReference type="OrthoDB" id="9989144at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000253">
        <property type="term" value="F:3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052834">
        <property type="entry name" value="3KSR/17beta-HSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44442">
        <property type="entry name" value="3-KETO-STEROID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44442:SF1">
        <property type="entry name" value="3-KETO-STEROID REDUCTASE_17-BETA-HYDROXYSTEROID DEHYDROGENASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS72031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="15989" checksum="D77A69E9A6B3338B" modified="2019-04-10" version="1" fragment="single">KNPYSSSKYATDVVSVGLNSRLNKQGVYSHSVCPGLVESNMTYGILPNWFWKLVLPFIFLMRLFVPSLTTSTFNGSESLLWLSSQDPRTLDSQIKFRSLVNVCGKPYVSNEKMKIDPDRAEDLLLELDKLQNSLDTHVKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H581</accession>
    <name>A0A3S1H581_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_019794</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001066">
        <property type="protein sequence ID" value="RUS72448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H581"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="476"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS72448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="502" mass="55550" checksum="60E3F2B31E42AF32" modified="2019-04-10" version="1">MATIFTLQLNTGSNMNSCISQEPFADSEASPDGYSMSSLTPTTATHRDDNGETQGRRSFYMDLMGDHLSTPPERFRVDQNCLQETSLHGHSSPLTCTENTIKDESATPSSARSCSKSSIRVPERKSFYAELMDGHGVSISKVNGQKAKPSDESRESDITSTLQVVKKVEKSSRKKAKSSDESRESDITSTLQVVKEKEKSSRKKSNSSNEIRERNVISALQVVKKVEKSSRKKAKPSNESRESGTTSTLQVVKEVEKSFRLSNPPSEYYTKDKELEESATLPLLGKTSTAMSTWEHFQAMNPSLRRHDSSAPGRSDLRKSDWNIPMPREHDSLSGKNLAEPGGKDTSQASISSSQALSQSGGREDVCMPRPLSVIIEESEEHDDHDDFDGSEQPWSQLLPWWDDSSKALQKVHAKQSSANGLDDDVKVEDHTVDIYTDVTLTFPEKLKVKDSPSKVMVMPLFQGRPKMTLSQTLQVAGLMVIGAIFVAFILAWVFSPVIFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HB92</accession>
    <name>A0A3S1HB92_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">G8 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_016453</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CEMIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000711">
        <property type="protein sequence ID" value="RUS75792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HB92"/>
    <dbReference type="STRING" id="188477.A0A3S1HB92"/>
    <dbReference type="OrthoDB" id="190675at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052252">
        <property type="entry name" value="CEMIP/CEMIP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055401">
        <property type="entry name" value="CEMIP_beta-hel_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055400">
        <property type="entry name" value="CEMIP_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019316">
        <property type="entry name" value="G8_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039477">
        <property type="entry name" value="ILEI/PANDER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15535:SF17">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15535">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24606">
        <property type="entry name" value="CEMIP_beta-hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24605">
        <property type="entry name" value="CEMIP_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10162">
        <property type="entry name" value="G8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15711">
        <property type="entry name" value="ILEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01225">
        <property type="entry name" value="G8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51484">
        <property type="entry name" value="G8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="G8" evidence="8">
        <location>
            <begin position="53"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS75792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1159" mass="130456" checksum="8DB9ECC3AD500598" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HDC0</accession>
    <name>A0A3S1HDC0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coiled-coil domain-containing protein 51</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_015160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000612">
        <property type="protein sequence ID" value="RUS77077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HDC0"/>
    <dbReference type="STRING" id="188477.A0A3S1HDC0"/>
    <dbReference type="OrthoDB" id="6243211at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037660">
        <property type="entry name" value="CCDC51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28624">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28624:SF1">
        <property type="entry name" value="MITOCHONDRIAL POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS77077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="46365" checksum="C54360EFDA4C13E5" modified="2019-04-10" version="1">MTASIIVNIGRMPKYPRVTTDRVCHVLFVLQQRANICRTAGIHYFHKECTDNQANNVRRKQSQTLLPSPLTLTQLSRQYSSSSETTHQQSLNSVAQERLGHVMQMYEDFVGLTEVKEAQNKVVSAEQKFLQVQEDRRVMQAELLSVQADVRAVGAELEKTSRTDSRYIDLVKREHEALLVEKDMVTKIKALDKAERDFFALLSAALRESHEKERSRAERTKYWSITGSIIGAIIGIIGSTVNNMRRMKELRAIVTESGENTAEYKDLVTRTLQSVDDQKSKVEDFFNSLSISQSQELQKLSGTDQPLLLTADVFLNKEDLTKSTETIIETLEKQSNHFSSQLQEILKIAGVSHAQEGSSHVIYAGPEVESLLAKTEENLQNKMNKNVMITSVVVSSVVTLGVGLLAFIFRGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HMQ3</accession>
    <name>A0A3S1HMQ3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_009709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000282">
        <property type="protein sequence ID" value="RUS82537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HMQ3"/>
    <dbReference type="OrthoDB" id="6137083at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS82537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="224" mass="25765" checksum="F530AA8801707921" modified="2019-04-10" version="1">MEGTAEEEEMQSLKNTESKGGARPKHFHLPCACKDTRSSSESEAEDEDVRVDEECSMDVYTFKKNKRGCGRSFSSNIAAYAGCSRDTTITNISKEEADLYSVFKISHPAQDPWLSEGIVSRQARQRAECTPRDQTTHQSNQYALLEFGCSCKLIGGGGGEEEEEKKKKKKKKKKKKKKKKKKKKKKKKGEEGEQMEEEEEEEEEEEEEGRSRRRRRRRRGKRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HS05</accession>
    <name>A0A3S1HS05_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Prospero domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_007276</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000187">
        <property type="protein sequence ID" value="RUS84965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HS05"/>
    <dbReference type="STRING" id="188477.A0A3S1HS05"/>
    <dbReference type="OrthoDB" id="10038576at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.500:FF:000005">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.500">
        <property type="entry name" value="Homeo-prospero domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023082">
        <property type="entry name" value="Homeo_prospero_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037131">
        <property type="entry name" value="Homeo_prospero_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039350">
        <property type="entry name" value="Prospero_homeodomain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12198:SF0">
        <property type="entry name" value="HOMEOBOX PROTEIN PROSPERO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12198">
        <property type="entry name" value="HOMEOBOX PROTEIN PROSPERO/PROX-1/CEH-26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05044">
        <property type="entry name" value="HPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51818">
        <property type="entry name" value="HOMEO_PROSPERO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Prospero" evidence="7">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS84965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="155" mass="18483" checksum="C9FEA6B35C65BCBA" modified="2019-04-10" version="1">MHLRKAKLMFFYTRYPSSSILKMYFPDVMFNKNNTAQLVKWFSNFREFFYIQMEKYARQALAEGVKGEEELVVTVDSELFRHLNLHYNRNNQIEVPQNFLVATQAALREFFKSVQASKDSEPSWKKAIYKIIARMDESLPDFFKAPNWMEQLGDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1I0R6</accession>
    <name>A0A3S1I0R6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Aminopeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">EGW08_002309</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">EC2010</strain>
            <tissue evidence="20">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000044">
        <property type="protein sequence ID" value="RUS89957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1I0R6"/>
    <dbReference type="STRING" id="188477.A0A3S1I0R6"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000012">
        <property type="entry name" value="Aminopeptidase N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF290">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="18">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="19">
        <location>
            <begin position="177"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="17">
        <location>
            <begin position="409"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="481"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="484"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="503"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="16">
        <location>
            <position position="566"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RUS89957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="22">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="612" mass="69784" checksum="579DA6D02871C02F" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1I3C2</accession>
    <name>A0A3S1I3C2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_000774</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000011">
        <property type="protein sequence ID" value="RUS91450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1I3C2"/>
    <dbReference type="OrthoDB" id="8196546at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS91450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="204" mass="23385" checksum="3E7F8C85E8054DDB" modified="2019-04-10" version="1">MQLGNSEVKTKQTLVQVDQVLLCFSTTKEKKGFGVQVARALFLNALLEDYDSTVTPTFDKSQPTNVNVSVYINNIDAVNEQTMHYISYIVDELQEQCQRSLHATMQRRKISLHLKGSTMLKNDSSSDRRKLAYYGHIRRHCSIQKRVVEGKVEGKRGRGRKRQSWLANIQETSQLRLSVACEAALDRERWRRMTAHLGDGTAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SKR5</accession>
    <name>A0A433SKR5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_022518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001596">
        <property type="protein sequence ID" value="RUS69718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SKR5"/>
    <dbReference type="STRING" id="188477.A0A433SKR5"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS69718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="182" mass="21207" checksum="6E990352EF8FBBBB" modified="2019-05-08" version="1" fragment="single">CSVCDWLSLKFSYPCSVCDWLSLKFSYPCSVCDWLSLKFSYPCSVCDWLSLKFSYPCSVCDWLSLKFSYPCSVCDWLSLKFSYPCSVCDWLSLKFSYPCSVCDWLSLKFSYPCSVCDWLSLKFSYPCSVCDWLSLKFSYPCSVCDWLSLKFSYPCSVCDWLSLKFSYPCSVCDWLSLKFSYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SLI0</accession>
    <name>A0A433SLI0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_022247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001517">
        <property type="protein sequence ID" value="RUS69993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SLI0"/>
    <dbReference type="STRING" id="188477.A0A433SLI0"/>
    <dbReference type="OrthoDB" id="6059742at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS69993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="439" mass="50707" checksum="9FFA7C2E1F094218" modified="2019-05-08" version="1">MREYFRAFRDQNITHRDYRPHFRPVLAYLEGAWTVSAPDSIEESFDSDRHRLDANSWFDMQERIRYTSTVGTKDPDENFANLPTSMIGINPETDEPIYVQWNYRIMGWPIDLPDLPTKYMRFEDDLMVRYPRGYTVEDAKNHRTAHFRFDENDTPRYTVGETLLDKIVSKIPGKDNIPDLLTDDIFGNNLYHEGFDNLTLLNLGYYNHWFKQNRPGAMGTSGRDHKSFPAMYAEYPNRDGTNHPDKAFNGTNFRNFYRIPSEFYESVQGNEDPADTAKSGVFVLDQEGNIRRCEASGLFLKTPMIPDVGRIRLRYPIAPIHQYGSPVWKELNAFKDTFRDYVNSVKVEAVTFEMSPASATFGSHTHMFIITGEQYRQIRAGNTLKVETTQAFAHTHSLTIQFNSKSGRFEYSRCGNNALCGDQHATLLHIVSSSLDLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SMY3</accession>
    <name>A0A433SMY3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_021702</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001386">
        <property type="protein sequence ID" value="RUS70536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SMY3"/>
    <dbReference type="STRING" id="188477.A0A433SMY3"/>
    <dbReference type="OrthoDB" id="7700931at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS70536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="162" mass="18061" checksum="A98261BF13E335F5" modified="2019-05-08" version="1">MPDDYALDFVTSTNLKEMHSLPPLEKQKIFWRHAVNGSTLYYEDLQNELTVGELLPNGVSLDCHDDNVFVRYKTIRSQVKQSNLITSNGVIHVLAKFLYDFRAVKDPSDPTAAPRVTPATNRPGTPSTIVGGLQGGVALRAPLMLVGVVYSFVLVLGWYQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SPA2</accession>
    <name>A0A433SPA2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Neurotransmitter-gated ion-channel ligand-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">EGW08_021196</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">EC2010</strain>
            <tissue evidence="18">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Synaptic cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001282">
        <property type="protein sequence ID" value="RUS71038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SPA2"/>
    <dbReference type="STRING" id="188477.A0A433SPA2"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18997">
        <property type="entry name" value="LGIC_ECD_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000073">
        <property type="entry name" value="Neuronal acetylcholine receptor subunit alpha-9-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000016">
        <property type="entry name" value="Nicotinic acetylcholine receptor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 15" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5022248208" description="Neurotransmitter-gated ion-channel ligand-binding domain-containing protein" evidence="15">
        <location>
            <begin position="21"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="299"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="16">
        <location>
            <begin position="31"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="17">
        <location>
            <begin position="244"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RUS71038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="42378" checksum="0A44C239A2E7D2D5" modified="2019-05-08" version="1" fragment="single">MDMWQPLFALITFLIGACLSQGLGYYGSDDEYRLVRDLMKGYNKQVKPSVINNQALNVSFGVALAQIIDLDEKNQIITTNCWNTQIWHDPKLTWDPKKYGSIEVVRLPYDTVWLPDIVLYNSAHLADESVSTNVIVNSNGTVMYLAMVIYKSSCSIDVKYFPFDSQHCTLDFSSWTYDLQGMNLILLGGEDGDLSNYKNSTEWELVGFLQEREVVKFSCCEVPYPFIKNHIKIKRRPLFYVFNMIFPCVLITLVALLGFYMPSDTGEKISMGITTLLSMTVFLMIVADQMPPTSDNLPLVGLFYGITIAIVSSATGMTVFVLNIHHKGQRGREVPRLAKKIFFGIVARMLFLTLDLDDMPPDHKQANPPKGPKGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SR14</accession>
    <name>A0A433SR14_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Immunoglobulin subtype domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_020547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001174">
        <property type="protein sequence ID" value="RUS71689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SR14"/>
    <dbReference type="OrthoDB" id="10627883at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS71689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="21939" checksum="D5246FD885580226" modified="2019-05-08" version="1">MGREVRKEGEGVEEGGGGMEEEGGYSFTCMAAVSLTSQISVTYTLLKNDVQVESARDNQTFTVRDVSNGDAGRYTCVHTFDNQWSPRSNEMVVTVVVGPTHTRRLQGCPSRQGYRQSCDTDLNRCQCEDAYTRKGNECVLGEIVCNHWSVVELFFCSCCCYILYHTVAAAAAAAAADDDDDDDDDDDDDDDDDDDDDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SRS8</accession>
    <name>A0A433SRS8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_020256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001133">
        <property type="protein sequence ID" value="RUS71986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SRS8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS71986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="303" mass="29956" checksum="A99C7E4FA3C31421" modified="2019-05-08" version="1" fragment="single">FSTESHTGSIVVRVQSFSSWSQSLPTHPTGPKSSLGSSRSCTAQRVDDAGQEVEVTLQLAGGRAHAQVQTAGQHVQTSERSGSGGVGALAGSELTPALGSTAIGTATSRGTRLGAHAAYSVAQVAENLRKAAVFALVAMLASMAYATPCTDICNAQCTIQKQTCSFAEIFGNLCDTVGGVCAQSCAAACSCADSCAAQCGGEFATCKSADSSAAGPFGGVGALAGSELTPALGSAAIGTATSRGTRLGAHAAYSVAQVAENLRKAAGLLLDGALGVTDVSAGGCVGHGGQHGDKSEDCERVHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433STC5</accession>
    <name>A0A433STC5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_019836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001072">
        <property type="protein sequence ID" value="RUS72399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433STC5"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS72399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="173" mass="18304" checksum="FC9B4366191004FB" modified="2019-05-08" version="1">MTANTMSCYKIAALSTGGSRIMTANTMSCYKIAALSTGGSRIMTANTMSCYKISALSTGGSRIMTANTMSCYKIAALSTGGSRIMTASTMSCYKIAALSTGGSRMTAITMSCYKISALSTGGSRIMTASTMSCYKIAALSTGGSRIMTASTMSCYNWWTRQRLVAHCLSRWEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T017</accession>
    <name>A0A433T017_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_017349</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000790">
        <property type="protein sequence ID" value="RUS74884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T017"/>
    <dbReference type="STRING" id="188477.A0A433T017"/>
    <dbReference type="OrthoDB" id="61815at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043358">
        <property type="entry name" value="GNL1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709:SF2">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS74884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="146" mass="17010" checksum="EDBF57B4C9814F4C" modified="2019-05-08" version="1">MGRRKGQIAMMGNSLLVKDKHKRHGHRGNKDDSFLHTTDLDDGTTYNRINFQSVTEQSNLEDFLNTAEMAGKDFTAERQNIHIITNPGQGKRLTEADMREISLAQTTHKALLQIPRRPQWDENTTKENLLMMERDSFTDWRRQLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T2Z7</accession>
    <name>A0A433T2Z7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_016319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000700">
        <property type="protein sequence ID" value="RUS75931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T2Z7"/>
    <dbReference type="STRING" id="188477.A0A433T2Z7"/>
    <dbReference type="OrthoDB" id="40118at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050715">
        <property type="entry name" value="LRR-SigEffector_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45752:SF187">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45752">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS75931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="553" mass="61860" checksum="34EFAAD382A0E8C1" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T3Y6</accession>
    <name>A0A433T3Y6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase M13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_015949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000675">
        <property type="protein sequence ID" value="RUS76277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T3Y6"/>
    <dbReference type="OrthoDB" id="10526299at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="1">
        <location>
            <begin position="35"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS76277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="585" mass="65776" checksum="7703A48EA5D2FE23" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T5Y9</accession>
    <name>A0A433T5Y9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_015255</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000620">
        <property type="protein sequence ID" value="RUS76968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T5Y9"/>
    <dbReference type="STRING" id="188477.A0A433T5Y9"/>
    <dbReference type="OrthoDB" id="432835at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018503">
        <property type="entry name" value="Tetraspanin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF478">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00421">
        <property type="entry name" value="TM4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="165"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR002419-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS76968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="259" mass="28887" checksum="F1BE575FF6FE058E" modified="2019-05-08" version="1">MGREKTSFCIVKYIFFVFNIFLWLVGCAVLAVSIWVWASRGTSLAVIPTYSFMSSTSLGIIAGILILGIGFMGCLGAFFENQCLLIGYFVLVLFVFALEVTAGTLGFVYKANAREIVREELSGGIRHDYLTVVQLQKQNRTGAYYDADAKGWSTSLDSMQRDLQCCGADNFTDWYDVKAWPGERKVPESCCLKPKPGCGDAGNIAQWHQRGCIDEMDYWLTRHMYIMGVTGVTVASIQILAMVAAIAQFCYIRSKRFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T6K0</accession>
    <name>A0A433T6K0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_015013</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000598">
        <property type="protein sequence ID" value="RUS77221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T6K0"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS77221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="221" mass="23333" checksum="34506D6D29B1FAA0" modified="2019-05-08" version="1">MACWCLALNSHHACEFPVMHQCFLSSRSPEHNLDRALISGAALVGSSNTGVGGTPGKEGGVWWGGGGIVELKVEVGSGGSETSDRARMFKNVSPNRYVRSSKTTIGQNIFDHLRPLLVGSVSALSDRVRYDFGLSNQSRHCLPHPHPKLPVLPGGELREGIITEALTLIEDDNSSLISVTLGQREFVTPSRGLKPGDLGAGPAARVSQGGQAISRLGSCPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T8L9</accession>
    <name>A0A433T8L9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_014306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000542">
        <property type="protein sequence ID" value="RUS77932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T8L9"/>
    <dbReference type="OrthoDB" id="7441410at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS77932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="167" mass="18604" checksum="118E22AFE0083FDE" modified="2019-05-08" version="1">MFPTYVTPAALVFPTYVTPAALLFPTYDTPATLMFPTYVTPATLMFPTYVTPAAVMFPTYVTPATLTFPTYVTPEPLMFPTYVTPAALMFLTYVTPEALMFPTCVSPAALMFPTYVTPETLLTYVTPETLLTYVTPETLTFLTYVTPETLMFPTDVTPKTHAHLEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T9N7</accession>
    <name>A0A433T9N7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_013953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000520">
        <property type="protein sequence ID" value="RUS78289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T9N7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS78289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="236" mass="25555" checksum="DC20170A0440466A" modified="2019-05-08" version="1">MDIWCAYQSTCLDLCKICAHRKNLALGCFKTVKRPSPACTPSARSPETVTRTETPDQPDQASQDFDETHNFPQETDTEITNTDFNNTDCSASTSVIANNSTTSHPSESSFNTINTPIIPITESGLSGRASSPLSVQLWVISGQALRPGPPSAVLPVPSSCHSTTVLCAWWLGGQRARHTGQLGPALVLETTRLVMDGRSESSHLKRRSSAARASWSLLLLHPGLEAHAPKQRHCHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TAR7</accession>
    <name>A0A433TAR7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_013606</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000498">
        <property type="protein sequence ID" value="RUS78636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TAR7"/>
    <dbReference type="STRING" id="188477.A0A433TAR7"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19178">
        <property type="entry name" value="SET_SETD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1410.10:FF:000007">
        <property type="entry name" value="Ribosomal lysine N-methyltransferase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1420.10">
        <property type="entry name" value="Rubisco LSMT, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011383">
        <property type="entry name" value="N-lys_methylase_SETD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036464">
        <property type="entry name" value="Rubisco_LSMT_subst-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044430">
        <property type="entry name" value="SETD6_SET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF34">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE SETD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011771">
        <property type="entry name" value="RMS1_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81822">
        <property type="entry name" value="RuBisCo LSMT C-terminal, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="7">
        <location>
            <begin position="52"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="221"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS78636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="491" mass="55498" checksum="32930A510B4361B3" modified="2019-05-08" version="1" fragment="single">MAAPIKRKCEVENGEHHVEKQPKGDVAVEDKSSSTLSRFISWCDKHNFQISPKVTVSRIGSCAQWGMHAVEDIAEGYCIFQVPRTALLMPAQSDIADKVDIESPELTSTNQWVPLLLTLLYESSKPDSKWSPYLALAPDPESIDLPMFWDQAEVDRLLRGTGVEKAVKRDLDMIESDYNNLVLPFKQKMNGKISDDAVSLSNFKRMVAFVMAYSFTEPAHKKLDTSESGDENKEEEEEEEDEDSEKLQPPMMVPMADMLNHITKHNAKLTFGAEALKMVTIRAIQKGEEIFNTYGQVSNLHLMHMYGFAERYPENTNDVVEIPVTRLLEAAKENCEEESQSKLIESKWELLKKQDVIDDDVVVLGRDGILNDDVCRQVLKVLCKDPSQFSEYVEKEGWSDAESEASDTETNGLDLSHIPQLDPEQKVLLRRMGELHLEDYAISIDDATKKMERANQLPLRERYALFTAHGQQMLIEQLIKACSATTCAGCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TDD4</accession>
    <name>A0A433TDD4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pericentrin/AKAP-450 centrosomal targeting domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_012673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000444">
        <property type="protein sequence ID" value="RUS79543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A433TDD4"/>
    <dbReference type="OrthoDB" id="6161297at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1179"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1256"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="4"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="235"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="386"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="530"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="770"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1181"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1195"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1260"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS79543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1459" mass="167109" checksum="104A5626303A7724" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TE34</accession>
    <name>A0A433TE34_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sushi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_012377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000424">
        <property type="protein sequence ID" value="RUS79851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TE34"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019548076" description="Sushi domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS79851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="23313" checksum="FF9D141E2AEE1A4E" modified="2019-05-08" version="1" fragment="single">MVFLLHKLWMFALGAVCHAQHFLDGKIVGVSQGRRCERLPDQEHGHFVCLRGHSGAPQKCRLSCPPGYTAPITYTPPTGLMDVKLRGLYVCTKFAGGLTWSPPLLMDCVEKKSATKLSLHSELNFHLPCNDQTDLDTIQRDMLFKLRNESHLLNSSCLDHMVTCQVELFLECNGTIVGDIEVTIPYTEDNAEIFPHFRKSVDNSLGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TFN2</accession>
    <name>A0A433TFN2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EGW08_011905</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">EC2010</strain>
            <tissue evidence="17">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000398">
        <property type="protein sequence ID" value="RUS80336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TFN2"/>
    <dbReference type="STRING" id="188477.A0A433TFN2"/>
    <dbReference type="OrthoDB" id="4748970at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000018">
        <property type="entry name" value="Krueppel-like factor 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000237">
        <property type="entry name" value="Krueppel-like factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000736">
        <property type="entry name" value="Zinc finger protein 423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF158">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0010">Activator</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="259"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="289"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="93"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="243"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RUS80336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="342" mass="39157" checksum="9B365808071439B5" modified="2019-05-08" version="1" fragment="single">YEQLLDLDFILNNTVDEASSDTNASKRVIKQELQSQQSGIPDFQSTFFDIPPIKFDDECMDVANTSDNMNINDNNCLSNMMMMFNNDIGHNGVNSANSPSHGPLPPYISMNGHSQNQMNVRPLQSQHHHHHHQQQQQQKQQQSMVPSSTKLLPHHPHPYQHQHLNHRHQHQQEQQRCPPHVTNQHHSHPHMAVGAPGPAMSPASHQIITPPSSPQLDQILLPSQPQQQQQAALSPMGVPPVQPKKRGRRTWGRKRQTSHSCSHPGCSKTYTKSSHLKAHLRTHTGEKPYHCSWKGCGWKFARSDELTRHYRKHTGDRPFQCHLCERAFSRSDHLSLHMKRHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TP57</accession>
    <name>A0A433TP57_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_008872</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000246">
        <property type="protein sequence ID" value="RUS83369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A433TP57"/>
    <dbReference type="OrthoDB" id="10012602at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="119"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="1">
        <location>
            <begin position="241"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="476"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="635"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="774"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1022"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1078"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1119"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1208"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1380"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1453"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1564"/>
            <end position="1583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1599"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1686"/>
            <end position="1707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1742"/>
            <end position="1786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1990"/>
            <end position="2010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2188"/>
            <end position="2212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="504"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="539"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="647"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="685"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="774"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="824"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="838"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="876"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="891"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="951"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="985"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1047"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1238"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1268"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1382"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1404"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1457"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1476"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1487"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1573"/>
            <end position="1583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1607"/>
            <end position="1617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1619"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1742"/>
            <end position="1772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1990"/>
            <end position="1999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2000"/>
            <end position="2010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2190"/>
            <end position="2212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS83369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="2251" mass="245614" checksum="A2425B0230D0110B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TQN2</accession>
    <name>A0A433TQN2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_008348</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000226">
        <property type="protein sequence ID" value="RUS83867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TQN2"/>
    <dbReference type="STRING" id="188477.A0A433TQN2"/>
    <dbReference type="OrthoDB" id="10005910at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044715">
        <property type="term" value="F:8-oxo-dGDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044716">
        <property type="term" value="F:8-oxo-GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22769:SF56">
        <property type="entry name" value="8-OXO-DGDP PHOSPHATASE NUDT18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22769">
        <property type="entry name" value="MUTT/NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="41"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS83867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="329" mass="36457" checksum="4E23B1682A425762" modified="2019-05-08" version="1">MGVEDDLRRIIAGQAVSVGTIIDVKPESSQEEKFIPMTKTNMCYICGAVIFDEAGKVLMIQEAKKSARGEWYLPIGRLERNETILSGALREVKEEAGIDCEFSTLLSVEMQGNTWMRFTFFGTIKEGTRLKSLEEQDSESLQAKMFTMEELHQSRHLIRAPDVFKLIEAGRKYWQTSSVDRRPSCFPVVAPHMQLLHRVVIIDRASSKHYPISILVNTSGEEHIPLTLLNFGRHGHLAASVYGILKVALSSNLDASTSSVRMCGILGVEHKGTGDLQDGVCLTSIVSLDLATPPPAAVLAQYEWRTLADKDLVDKVEVAAKGKLVPFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U0Q7</accession>
    <name>A0A433U0Q7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_004850</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000112">
        <property type="protein sequence ID" value="RUS87396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U0Q7"/>
    <dbReference type="STRING" id="188477.A0A433U0Q7"/>
    <dbReference type="OrthoDB" id="9000293at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004104">
        <property type="term" value="F:cholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00312">
        <property type="entry name" value="Esterase_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000029">
        <property type="entry name" value="Acetylcholinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019322942" description="Carboxylesterase type B domain-containing protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="34"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600997-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS87396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="555" mass="61810" checksum="37EB365F62BAC81A" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U169</accession>
    <name>A0A433U169_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_004634</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000106">
        <property type="protein sequence ID" value="RUS87589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U169"/>
    <dbReference type="OrthoDB" id="6208012at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030594">
        <property type="term" value="F:neurotransmitter receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007187">
        <property type="term" value="P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247:SF202">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="39"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="292"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="373"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="292"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="344"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="373"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="425"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS87589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="537" mass="59864" checksum="2AC26F9801C23BB0" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U295</accession>
    <name>A0A433U295_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_004306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000096">
        <property type="protein sequence ID" value="RUS87951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U295"/>
    <dbReference type="OrthoDB" id="6141669at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47018">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47018:SF3">
        <property type="entry name" value="MYCBP-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS87951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="322" mass="37114" checksum="B769F4118243FE44" modified="2019-05-08" version="1">MREDVTVLEALERLLFAKFEQDRDSKLSKDLMTFMTTKELTNEMSSSTAKKILQSGVHTELFSQYEAFKENVRSGKYGKTAQYWIQYMDRVWLLLQFVQATKTNNFSLHVSCLKDLCPLIFTMNHQNYARYLSMYNVSLANLSLSHPGAKELLQNKGFSVSRSRKPAGRIAVDMTIEQTINKHVKSKGGIVGFSGNLPGYYRWSVTRHNRAEYVSATLKMINNRCSDTDSHKELNPAEKRMFQNPSIPKPEDNGWQRNSANELEVQWFKDAFIPDELHDIVTEEICTRTDEETYDDDSFDSDFLDDSSEDEEDIATDDEDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U2W3</accession>
    <name>A0A433U2W3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_004064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000091">
        <property type="protein sequence ID" value="RUS88167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U2W3"/>
    <dbReference type="STRING" id="188477.A0A433U2W3"/>
    <dbReference type="OrthoDB" id="424310at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS88167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="656" mass="74727" checksum="D84A38336637C5B8" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U3W6</accession>
    <name>A0A433U3W6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_003769</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000081">
        <property type="protein sequence ID" value="RUS88511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U3W6"/>
    <dbReference type="OrthoDB" id="6153483at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15039">
        <property type="entry name" value="7tmB3_Methuselah-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053231">
        <property type="entry name" value="GPCR_LN-TM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902:SF1">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="6">
        <location>
            <begin position="192"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS88511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="511" mass="56678" checksum="A92AEF10A68D1F6F" modified="2019-05-08" version="1" fragment="single">LNALSAFWVQGYVGANTSLSRDEFEARVLEELIDTPISMQYVDYETKLEAQINLGETDTVDLCLKPNIECIVIQERKIRLESNIFEYTDSFINFGKVLTCQTVHFDSTAYRITKSLTTDALPTTKVSLQLGETSLAFSEPKDLNQMSIGQDLSLTVCKGLLDSALQSLDEERRREYYSRDFRAEVDDITQAQYYTTLVCVGASITCLFLALMTYFLFNVLRSVAGINNMFLCASLLLAQASLLASVHVSGPQTLCTVLGFLTHFLWLWVFAWSFICCFRMFKVFTAKTRQDKSDKSLTATVVRTALLSVAAPALVICSVVTASLLTSGGRRCGYGRESCYLDSPLLIGLSTALPLAIVTASNIGFFSLTVARIRSVKRLQSSDFCRKEDQRDLAIYVKLSTMTGSFWLTQIVAEAADLNFLRFVAILLNGLQGVFIFASYICNKRVLNLYLRMLGMEPMTLTSSGSQRGGSTAKISLGALASKLRKGDNPNRKALESDAGVEEIKENVFEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U5T7</accession>
    <name>A0A433U5T7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_003066</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000063">
        <property type="protein sequence ID" value="RUS89187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U5T7"/>
    <dbReference type="OrthoDB" id="9993736at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001614">
        <property type="entry name" value="Myelin_PLP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11683:SF12">
        <property type="entry name" value="M6, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11683">
        <property type="entry name" value="MYELIN PROTEOLIPID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01275">
        <property type="entry name" value="Myelin_PLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="279"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS89187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="408" mass="46196" checksum="C28BBD81A8F757B1" modified="2019-05-08" version="1">MSGSLLDMESPVIDEEGHVLKHADSDSVNSIPPPPPPLGMSTVPVASEESCDITEQERLRQADDDDEAERQHRELEAQQLQQQHLYAEPHQLRQEHQQHLQQQQQQHENHSHHEEDQSFQQQQNPEEEPLQPLQQHQSNEEDGAENDTQELQAQQQMLVAVEPTTSSKQKEAADGHSDTCCDKFLKCLGLVPCPTLLSWILLLLGLGCMVGAILFGTWDTRTLLDDDDLLWFMEYTVIGVSVGMFVVGCLVLLSSHLSSEPTSRRVFNSFKKNRCAQGMNIFALVVCYILTVVWVLATAIFGVPLVLIINMFIVDADSVDLGFLFCVIKLIHFFFFTSVTFFNLLFNNTYFLLKSVFTAVFFSHPQICFIICITANITHLRDNRFSTLNAYGSEEVRNSKHSVLDTNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U7E8</accession>
    <name>A0A433U7E8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_002459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000048">
        <property type="protein sequence ID" value="RUS89756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U7E8"/>
    <dbReference type="OrthoDB" id="75343at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS89756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="214" mass="23754" checksum="3BE03D1989027B1C" modified="2019-05-08" version="1">MASNIKKAGSALKKSFRQRRFLSSLELDENVYTDASPRAGSYRKMKDSRSGPSSSSSPVPASQMNEDETTNNRTTVKRGASMTQSMREAVGTIRQKFRMSTRRLTRLQSQTPPGRAGKTRRHTLGGKDVKMLSPFGIETPRRSGSSDPKSCLSMETPTRLRKEVEALTSNMQALSALTPNTLQARARARRDPPLINGSLKTTRSKRRSVTTDIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U927</accession>
    <name>A0A433U927_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_001921</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Antp homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000035">
        <property type="protein sequence ID" value="RUS90323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U927"/>
    <dbReference type="STRING" id="188477.A0A433U927"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000193">
        <property type="entry name" value="Ultrabithorax, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050296">
        <property type="entry name" value="Antp_homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45659:SF4">
        <property type="entry name" value="HOMEOBOX PROTEIN ABDOMINAL-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45659">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="102"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="104"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="79"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="170"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="181"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="241"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS90323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="257" mass="28885" checksum="53BA84189368A78C" modified="2019-05-08" version="1">MGYPLTDGERGVHSIAIIFCGHSGLESLWFPRKYHTERSLGGFFELSHMLCLTERQIKIWFQNRRMKEKKELQAIKELNEQSRGHDKPQAAAAANGNGPNSNQRRRGRQTYTRFQTLELEKEFKFNRYLTRRRRIELSHMLCLTERQIKIWFQNRRMKEKKELQAIKELNEQSRGHDKPQAAAAANGNGTTNNSSSNTTTNNNNNNSSSSNNSGGVHVNGSAVKPEGGIKASPGSILAGHQHNQSLGSPTSSGSEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U9G0</accession>
    <name>A0A433U9G0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_001781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000032">
        <property type="protein sequence ID" value="RUS90440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6163231at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="652"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="830"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1234"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1371"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1627"/>
            <end position="1686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1714"/>
            <end position="1745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1754"/>
            <end position="1773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1821"/>
            <end position="2061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
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            <begin position="381"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="408"/>
            <end position="420"/>
        </location>
    </feature>
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            <begin position="423"/>
            <end position="437"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <end position="451"/>
        </location>
    </feature>
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            <begin position="452"/>
            <end position="464"/>
        </location>
    </feature>
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        <location>
            <begin position="580"/>
            <end position="590"/>
        </location>
    </feature>
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        <location>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="846"/>
            <end position="855"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="859"/>
            <end position="871"/>
        </location>
    </feature>
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        <location>
            <begin position="872"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1019"/>
            <end position="1033"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1234"/>
            <end position="1249"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1371"/>
            <end position="1389"/>
        </location>
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        <location>
            <begin position="1396"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1427"/>
            <end position="1439"/>
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    </feature>
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        <location>
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        </location>
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            <end position="1484"/>
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        <location>
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            <end position="1740"/>
        </location>
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        <location>
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        <location>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="1926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1956"/>
            <end position="2031"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS90440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="2061" mass="226436" checksum="6629F3B10993E98C" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U9N9</accession>
    <name>A0A433U9N9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase M12B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_001688</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000030">
        <property type="protein sequence ID" value="RUS90511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U9N9"/>
    <dbReference type="OrthoDB" id="7695528at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13688">
        <property type="entry name" value="Reprolysin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019382779" description="Peptidase M12B domain-containing protein" evidence="9">
        <location>
            <begin position="26"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="10">
        <location>
            <begin position="38"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS90511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="604" mass="66615" checksum="3B702665B2B96D42" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UAH9</accession>
    <name>A0A433UAH9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_001415</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000024">
        <property type="protein sequence ID" value="RUS90796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UAH9"/>
    <dbReference type="STRING" id="188477.A0A433UAH9"/>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000020">
        <property type="entry name" value="Dachsous cadherin-related 1b"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000080">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050971">
        <property type="entry name" value="Cadherin-domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025">
        <property type="entry name" value="DESMOGLEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025:SF23">
        <property type="entry name" value="NEURAL-CADHERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="573"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="16"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="120"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="229"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="333"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="443"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="546"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="630"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="773"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="871"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="548"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="631"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="667"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="683"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="732"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="938"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="986"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1004"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS90796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1048" mass="112861" checksum="4817F12D4E2BD811" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UCW1</accession>
    <name>A0A433UCW1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_000566</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000007">
        <property type="protein sequence ID" value="RUS91740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UCW1"/>
    <dbReference type="STRING" id="188477.A0A433UCW1"/>
    <dbReference type="OrthoDB" id="428111at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF73">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="2"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="100"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="313"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="354"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS91740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="581" mass="63674" checksum="6F0DD3B8B3A81729" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UDI6</accession>
    <name>A0A433UDI6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_000409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000005">
        <property type="protein sequence ID" value="RUS91838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UDI6"/>
    <dbReference type="STRING" id="188477.A0A433UDI6"/>
    <dbReference type="OrthoDB" id="6118231at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001888">
        <property type="entry name" value="Transposase_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF1">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01359">
        <property type="entry name" value="Transposase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS91838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="163" mass="18595" checksum="A37D5AB4CCD552B2" modified="2019-05-08" version="1">MIVANRRVKQKDIANALDISKERVHHIITVHLGYRKVSVPGQLTVEMKAQRKTICTQLLERFTHDGERFLRSIITGDESWVHHYDPESKMQSMQYRHKNSPAPKKFKVVASARKVLLTIFWDMEVGRLMELHGEGTTSTTTKAKPSEGGEKVDGYEPPVLDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UDS3</accession>
    <name>A0A433UDS3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_000306</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000004">
        <property type="protein sequence ID" value="RUS91904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UDS3"/>
    <dbReference type="STRING" id="188477.A0A433UDS3"/>
    <dbReference type="OrthoDB" id="6153870at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF66">
        <property type="entry name" value="OCTOPAMINE RECEPTOR BETA-3R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="91"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS91904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="305" mass="33877" checksum="1EA731D227A83D24" modified="2019-05-08" version="1" fragment="single">MSGPTIFVDGKNTSLGDDTSYATKDHAGWNSTSPLPYTRSNVRMDTTEHSLAWCHDLQGSDFIYTPTLYSTATRHAIAVAFIFLIIITVMGNAFVILTVVVDKPLKKITRALVVSMAASDILVALCGELQSVVTMLTEDVWTLSDTLCEVFTSADLYFSLSGILHIVCLAGDRYLAICYPFKYVRMGRKYLVISVVGAWTLPFLFSFLPILSHWHRLGQDDLYACLHGLEVHVCTMIPNKEFSTVTFSIMFGLPCLVMGFCYAQIYRTAMFHKDRMSFVTLGSYTSNTSAPLSSPRTASNEKVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UDV5</accession>
    <name>A0A433UDV5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_000344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000004">
        <property type="protein sequence ID" value="RUS91942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UDV5"/>
    <dbReference type="OrthoDB" id="5980459at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032045">
        <property type="term" value="C:guanyl-nucleotide exchange factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048814">
        <property type="term" value="P:regulation of dendrite morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029899">
        <property type="entry name" value="KNDC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21560:SF0">
        <property type="entry name" value="KINASE NON-CATALYTIC C-LOBE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21560">
        <property type="entry name" value="VERY KIND PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="919"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="686"/>
            <end position="695"/>
        </location>
    </feature>
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        <location>
            <begin position="702"/>
            <end position="714"/>
        </location>
    </feature>
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            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="788"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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    </feature>
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        <location>
            <begin position="935"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS91942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1173" mass="128075" checksum="D810435390F8B7EB" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UE39</accession>
    <name>A0A433UE39_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_000247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000003">
        <property type="protein sequence ID" value="RUS92034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UE39"/>
    <dbReference type="OrthoDB" id="10408235at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS92034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="178" mass="21214" checksum="7FD7F09F1F962236" modified="2019-05-08" version="1">MAMHLRDVFDLVKKQIAFHRKAEARQNTLTIQERREMLLSSENEFNSTFPWLTASFVRKLIGQKVDAPSGVLNVGYLYKIMEQLSTGQGFRTFLGVMRRNDLWCTIRHYGFGEVKNSNYLAHKLTRVRYMTSENRFFEKLITCFKTLSGFYIIIRHEKSTPLHNFIKRYERFNDEELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z409</accession>
    <name>A0A3S0Z409_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Corticotropin-releasing factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_022048</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001469">
        <property type="protein sequence ID" value="RUS70186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z409"/>
    <dbReference type="OrthoDB" id="10659356at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018782390" description="Corticotropin-releasing factor domain-containing protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS70186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="33642" checksum="0D6B580459E840CC" modified="2019-04-10" version="1">MELSCLIKASLLSLVVMVTVLDVCVTSAALPAMKCSESNKKECGNAHSNAITGSNAEGGQNVGLPSSSGSKKAESSQGEQLPGQQGQDQGQGHSVQPLSRRSRDIGAADREMLLQARGFVSRVMDNMAAEGAEPATVGWNSPGISGDALLRSFEVQRILSELKNNQLVRRLLQWSTTHSKPKQTDKEDELDSEEEEQEEEQEEEEEEDSLYPDTSVTGHNSELSSGRRAKNTAQAPWAEQQTRAESDLMRMSAGRVLSGSRLVQKRNPSHVSVNNAMMAITNMVRAQQKQRLMKNRELIRQHMLIQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z410</accession>
    <name>A0A3S0Z410_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Purple acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_023374</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="EMBL" id="RQTK01001962">
        <property type="protein sequence ID" value="RUS68863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z410"/>
    <dbReference type="STRING" id="188477.A0A3S0Z410"/>
    <dbReference type="OrthoDB" id="45007at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00839">
        <property type="entry name" value="MPP_PAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041792">
        <property type="entry name" value="MPP_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025733">
        <property type="entry name" value="PAPs_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="PAPs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45867:SF3">
        <property type="entry name" value="ACID PHOSPHATASE TYPE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45867">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14008">
        <property type="entry name" value="Metallophos_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="Purple acid phosphatase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018382858" description="Purple acid phosphatase" evidence="3">
        <location>
            <begin position="26"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="492"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase N-terminal" evidence="7">
        <location>
            <begin position="48"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="5">
        <location>
            <begin position="151"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase C-terminal" evidence="6">
        <location>
            <begin position="375"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS68863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="520" mass="59685" checksum="2D5490BC9952CA5B" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z6H5</accession>
    <name>A0A3S0Z6H5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_021844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001418">
        <property type="protein sequence ID" value="RUS70400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z6H5"/>
    <dbReference type="OrthoDB" id="10065669at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS70400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="151" mass="17449" checksum="DAA1D8E8EFB92942" modified="2019-04-10" version="1" fragment="single">MLLMSVINSELPRDSRISNVETLVNKTLCESVSKFCIERECSSCGVDALFSSFEEQISDLCKERKWSCWEKTERCSKDLVFRHSSVSEILSLLKQNVFLCFLNISRWLNGSVSSISFYRLTCQRAMQCALWTSQKIIFVNSKTKFRVHTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z6Q3</accession>
    <name>A0A3S0Z6Q3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_021657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001378">
        <property type="protein sequence ID" value="RUS70578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z6Q3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS70578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="113" mass="12292" checksum="D626605390EB5892" modified="2019-04-10" version="1">MQSLLKFAVISVLKFAVISVLKFAVIGVLKFAVIIVLKFAVIIVLKFAVISVLKFAVISVLKFAVIGVLKFAVIGVLKFAVISVLKFAMISVLKFAVISVLKFAVISVLKFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z720</accession>
    <name>A0A3S0Z720_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_023777</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="RQTK01002744">
        <property type="protein sequence ID" value="RUS68461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z720"/>
    <dbReference type="STRING" id="188477.A0A3S0Z720"/>
    <dbReference type="OrthoDB" id="6105237at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000026">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF8">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="8">
        <location>
            <begin position="454"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS68461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="964" mass="110551" checksum="E30CDAB3D9DB28A8" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z8B0</accession>
    <name>A0A3S0Z8B0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Armadillo repeat-containing domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_019225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000985">
        <property type="protein sequence ID" value="RUS73019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z8B0"/>
    <dbReference type="OrthoDB" id="6120180at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="799"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="801"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS73019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="840" mass="93162" checksum="27527ACA2E3FED0E" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z8U9</accession>
    <name>A0A3S0Z8U9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_022762</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001667">
        <property type="protein sequence ID" value="RUS69478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z8U9"/>
    <dbReference type="OrthoDB" id="5990390at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052224">
        <property type="entry name" value="THAP_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927">
        <property type="entry name" value="AGAP005574-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927:SF3">
        <property type="entry name" value="THAP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="117"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS69478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="206" mass="23828" checksum="1B7F52DC5CC4AEB3" modified="2019-04-10" version="1">MVQNCCVVNCSNRQIKNTPFSFHSFPWSDRHRLAAWISRISRKNPDGSEWCPKPCDKVCSSHFVKADFFKAHNRSKPCDKVCSSHFVKADFFKAHNRSILKTDAIPSVFPNYPKHKQVYSSRRKSPKRRVLVSPPTKSQPRPAISPSASIQLDHAYTFSSVEAHLQSTQRKLDFYLEKQQKQASELKKMKKQVQRRDKKIESLSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZCD3</accession>
    <name>A0A3S0ZCD3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="9">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EGW08_016600</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">EC2010</strain>
            <tissue evidence="15">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="9"/>
    <dbReference type="EMBL" id="RQTK01000722">
        <property type="protein sequence ID" value="RUS75646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZCD3"/>
    <dbReference type="STRING" id="188477.A0A3S0ZCD3"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06618">
        <property type="entry name" value="PKc_MKK7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000040">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000432">
        <property type="entry name" value="mitogen-activated protein kinase kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052468">
        <property type="entry name" value="Dual_spec_MAPK_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47238:SF2">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE HEMIPTEROUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47238">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="131"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="21"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RUS75646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="416" mass="47048" checksum="54F70D2FBB6F76A4" modified="2019-04-10" version="1">MSSSQFFLNKVNELQKRLMAENRSLDAERNADLGSPSPRRPRMLATGMPVATAASTPNFLAPPSSSRSSSAPSPGRRRPNMGGMKLDCGARSPLRIMPDSAEIDQKIEEIMKQSGILTFQGQRFLCDTEDLQPEGELGHGTCGQVTRMRHKPTNHLMAVKQMRRSGNKEENKRIIMDLDVVIKSHDCPYIVQCIGTFITKSEVWICMELMATCLDKLLKRTRRPVPERILGNIVVATVKALHYLKERHGVIHRDVKPSNILLDDRGNVKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIEPPDPTRPDYDIRADVWSLGISLVELATGEFPYKNCKTDFEVLTKVLQEEPPQLGREFSDELRSFVKDCLTKDFKRRPKYRKLLEHQLVKKAEAEKVDITPWFAEMSHLMEMNRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZE21</accession>
    <name>A0A3S0ZE21_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_019368</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001007">
        <property type="protein sequence ID" value="RUS72862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZE21"/>
    <dbReference type="OrthoDB" id="6070117at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="41"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="235"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS72862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="349" mass="39561" checksum="8133763B68A25D64" modified="2019-04-10" version="1">MTNDSVAGISTPPLLFSGEFYTSVKFLTSLWLAIISFGMLSNTTNFLVFLKSGLKDNVTILLFCLSISDISFLVLITPTVATSLIFVHAPTWPWPFDRRIVSFLLYWPAFTFYDFSAYLSVCLGVMRCACVAMPLHFKLVFTKSRTMAAVVIIFCSTILLRIPVLTVHSVGMKMNPLTNQSYAYLKKDSSEVKVFINDVLNRTSMPWVSFIIMVTCVIILTYKLFDASKVRLSHTSCPEPATNNPSDDQKTEGQQRREKHINQSMSSKEAQVVRSVVLVCVIFILSQLPFLLYSTARLIYPEFDEDTHFRFLFGFCSNISVTCSYLNASVNIFVYYKFNSHVTLGKDYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZG90</accession>
    <name>A0A3S0ZG90_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_015300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000623">
        <property type="protein sequence ID" value="RUS76927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZG90"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS76927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="221" mass="25760" checksum="11EACC9217A8CFD8" modified="2019-04-10" version="1" fragment="single">MKKQSQNNMPVDNPVAKESFITFPEKDLSRRTAVTHKKYVGLGWTRKASQPHVHKTHREHVERREQRDSIKEEARIREAAARARRKATGEDLSDEWSRSSDEQQKQVDTNDARKTASSIGESLQAGPDGMESEEVAANTQLMTSRKPSKEIRQSDDRRSRSHSSHRDKRQGRGRQPRVDKTSRKRSKEILREDDGRRRRSHSLSQRDMRQRSARQSREEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZJL4</accession>
    <name>A0A3S0ZJL4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_023309</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001917">
        <property type="protein sequence ID" value="RUS68933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S0ZJL4"/>
    <dbReference type="OrthoDB" id="6147158at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006259">
        <property type="term" value="P:DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052560">
        <property type="entry name" value="RdDP_mobile_element"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36688">
        <property type="entry name" value="ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36688:SF2">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="536"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="3">
        <location>
            <begin position="1017"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS68933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1359" mass="152885" checksum="65EAB6B0050FD5B2" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZLE1</accession>
    <name>A0A3S0ZLE1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_011818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000391">
        <property type="protein sequence ID" value="RUS80449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZLE1"/>
    <dbReference type="STRING" id="188477.A0A3S0ZLE1"/>
    <dbReference type="OrthoDB" id="9450131at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051864">
        <property type="entry name" value="NCF2_NOXA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15175">
        <property type="entry name" value="NEUTROPHIL CYTOSOLIC FACTOR 2, NEUTROPHIL NADPH OXIDASE FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15175:SF0">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN C23A1.17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS80449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="419" mass="45366" checksum="354CED4040111026" modified="2019-04-10" version="1">MDLKDTLAKWHTGMCLLDSNKSLDEAISVLLSIRSPSSKIIHNIGCIKMKQGLFLDAILCFNQSLEKDKYLALSYFQRGVCYYETQRFDGAELDFLTAQSMCPKDGINYRQLGADFVLSPELLGECLKVTRETLSLRRSGQFPKFDSDRCLFRPPKKMVDNLVKQDFLGKAKVISSTAEQDILYATDKMQNSSSAPRRSAQSSPSASTHQKIMVTPSGAKIVVPPRPTRPPPNLPATPDSRAPITRAGQRLVREKSRSAEDILDGGESQGYSLASCVGTNSSGSRLDMRADLASVLLSQRMTSGQAVTLPARRSDKSGKGLHVGRLDQDKPHFAQDGSASEARQDPKMMLKMPSPVGGAVVRPGAGQGTPADESAGKKSVRELANSFSQSGFAGPIAPGPRGDAKPLKPPRPPPPKIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZLR1</accession>
    <name>A0A3S0ZLR1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF1907 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_014368</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000546">
        <property type="protein sequence ID" value="RUS77855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZLR1"/>
    <dbReference type="STRING" id="188477.A0A3S0ZLR1"/>
    <dbReference type="OrthoDB" id="5119241at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17298">
        <property type="entry name" value="DUF1907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015021">
        <property type="entry name" value="C11orf54_DUF1907"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13204:SF1">
        <property type="entry name" value="ESTER HYDROLASE C11ORF54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13204">
        <property type="entry name" value="PTD012 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08925">
        <property type="entry name" value="DUF1907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01168">
        <property type="entry name" value="DUF1907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117856">
        <property type="entry name" value="AF0104/ALDC/Ptd012-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DUF1907" evidence="7">
        <location>
            <begin position="22"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS77855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="311" mass="34109" checksum="79D2691809D224FE" modified="2019-04-10" version="1">MSTLPVQKMCCHVPPLEEVAEVLQKGLAANFAVAEVKVVDCPDLSVAPFNLADKGLCGQPRLVDIGGVDHLKPFPRKDKNYELQKICDLCEMPSGGLVIGAGAGPNDVFGYNCEFICNARLGGDCPSDKSKISKVKEDGQSLQLDSNSGRFSLMGNFLISEGKPGKVLEVKVSQRTGKQNFVECLHQTLARHYGDGRGVGLGGTFLLQTGKANIHVMPGFLTEAMETEEQTLNWLKFYDMDAPLVHVGEVVSADPQGLHLRQEHFHCFSDHGHAGHYHYDTTPENASYLGYFSLAEALYRIDLPTNTKYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZMT0</accession>
    <name>A0A3S0ZMT0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_009531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000275">
        <property type="protein sequence ID" value="RUS82694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZMT0"/>
    <dbReference type="OrthoDB" id="20889at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47824">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47824:SF3">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="6"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS82694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="325" mass="36084" checksum="1EEE0B14DD78C255" modified="2019-04-10" version="1" fragment="single">MAAPMDVVFSFDTTGSMSQVLDEVKCRLNDLIQRLQADIPQLKVGIIAHGDYCDKDHFYDIRTLDLTNNLPDVVSFVSETTGTGGGDIPECYELSLRHARDMSWREGSRRVFVVIGDAYPHQPDYAQNTLKIDWQEELSSLVKKSVTVYGVQYGEDPESVSFFQRITGQSGGQHLRLQNMGDICHVIMAICYRENDPNQLQNYEAEIRANNADTALKSGLENVFDKLGNSTTAPAASHQLSKPSLALLSLLSSFSSVGSGDTAILRNNSIDEREGSGTIEKHTSIDYSCPPTPINMDTEWLSDDESNEDGPFKPPKQVKRKHTCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZN64</accession>
    <name>A0A3S0ZN64_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_013387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000486">
        <property type="protein sequence ID" value="RUS78845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZN64"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS78845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="111" mass="12686" checksum="ECEA39B201AB6489" modified="2019-04-10" version="1">MIFHYHLLFLNMTVGRFLKLLFCLSFLLEGFDCVQRTAAFKRVRTSEGAPDSIPQREELAVVVVVEEVVVSVVRTSIDQWLQGLRNSVVTVMDGNRPDVDKHKQAQVRQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZPM9</accession>
    <name>A0A3S0ZPM9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_008333</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000225">
        <property type="protein sequence ID" value="RUS83919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZPM9"/>
    <dbReference type="STRING" id="188477.A0A3S0ZPM9"/>
    <dbReference type="OrthoDB" id="10039931at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051574">
        <property type="entry name" value="ZnF_E-box_Homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24391:SF18">
        <property type="entry name" value="EG:115C2.6 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24391">
        <property type="entry name" value="HISTONE H4 TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="397"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="242"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="319"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="459"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="561"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="784"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="971"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="281"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="326"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="359"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="492"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="529"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="593"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="641"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="666"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="790"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="840"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="971"/>
            <end position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS83919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1049" mass="116401" checksum="D34D57E45280220D" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZQ43</accession>
    <name>A0A3S0ZQ43_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_012027</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000405">
        <property type="protein sequence ID" value="RUS80202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZQ43"/>
    <dbReference type="STRING" id="188477.A0A3S0ZQ43"/>
    <dbReference type="OrthoDB" id="10009315at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042352">
        <property type="entry name" value="EFCAB14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15717:SF2">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15717">
        <property type="entry name" value="PROTEIN KIAA0494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="427"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS80202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="60327" checksum="BA55C1AB5B508D15" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZU49</accession>
    <name>A0A3S0ZU49_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_009367</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="RQTK01000268">
        <property type="protein sequence ID" value="RUS82845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZU49"/>
    <dbReference type="STRING" id="188477.A0A3S0ZU49"/>
    <dbReference type="OrthoDB" id="5600252at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002151">
        <property type="term" value="F:G-quadruplex RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000500">
        <property type="entry name" value="ATP-dependent RNA helicase DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000002">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059023">
        <property type="entry name" value="RNA_hel_CTD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF237">
        <property type="entry name" value="ATP-DEPENDENT DNA_RNA HELICASE DHX36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26026">
        <property type="entry name" value="RNA_hel_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="367"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="620"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1136"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS82845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1166" mass="131554" checksum="7CB373E797A67AFB" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZUL9</accession>
    <name>A0A3S0ZUL9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_009033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000253">
        <property type="protein sequence ID" value="RUS83222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZUL9"/>
    <dbReference type="OrthoDB" id="10027339at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029266">
        <property type="entry name" value="FAM217"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22145">
        <property type="entry name" value="SI:CH211-266K22.6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22145:SF2">
        <property type="entry name" value="SI:CH211-266K22.6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="625"/>
            <end position="639"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RUS83222.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="639" mass="70778" checksum="E24E5473F11CF6D2" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
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    <name>A0A3S0ZV99_ELYCH</name>
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        <name type="common">Eastern emerald elysia</name>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000131">
        <property type="protein sequence ID" value="RUS86705.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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            <end position="100"/>
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            <end position="37"/>
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            <position position="1"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="RUS86705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="382" mass="41990" checksum="B70CAC2215CC1CC9" modified="2019-04-10" version="1" fragment="single">VVDSDSGKVLADVKQQTETDFIPSGGDSQPKTVSQTHIDIPSAGVHKTFVGGDRKSSEENTNGAAEAEDNADAAADVVAAAGAEGGDEGEDEEEPDLTPADMAAYLYETQQFGAFYAAMDRLVNQSKMSPEDAEAYARTVAVEYERLQLQDLEDRYMIERRSFHQSVPQNNFYGSAPGYDVYSPPMAVPESSDPSFDMLAYINSLMSPEEQFLAQRQAQNEADLTSSDTIDPYQFVAALWNEAYEHGNEEAQEIVRLLYDRVSQDSNPDDMGEIRDILLDTVAQSLGEDTPFVFDTPIDTPLNMPQMPVNQEEAELETSEGVANDAAQSEANEADKVPEKDEEKEKKEVEDETAGKEEKSAEDKEQVPKVEGKTGEQGEKKH</sequence>
</entry>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="188477.A0A3S0ZW10"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="39"/>
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            <end position="98"/>
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            <position position="1"/>
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    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS76617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="898" mass="99162" checksum="41127364FB71EE86" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZYP0</accession>
    <name>A0A3S0ZYP0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_013791</name>
    </gene>
    <organism evidence="4 5">
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        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
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    <reference evidence="4 5" key="1">
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            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
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                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000509">
        <property type="protein sequence ID" value="RUS78445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AGGF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23106">
        <property type="entry name" value="ANGIOGENIC FACTOR WITH G PATCH AND FHA DOMAINS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23106:SF24">
        <property type="entry name" value="ANGIOGENIC FACTOR WITH G PATCH AND FHA DOMAINS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="33"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="3">
        <location>
            <begin position="240"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="319"/>
            <end position="362"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="433"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
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    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS78445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="47623" checksum="B4AA49CC9BFE6CC3" modified="2019-04-10" version="1" fragment="single">EVAEQHPPCIRMIVLESDCLTLGSLVIITCAGGTIGREPDRDHVLELPDLNVSKVGSHFKWCFFPHHSDIFHIHARVEFDYNCSSYFVTDNGSQNGTLLNSQRLSESKTKSAAHHLSHGDVLEVGSSRLLLHIHSGHETCEDCEPGQVQAKLRALNPVKNDHVILSKDEKNRQRIKELKQIKKRYGLQNSYFENSGASISNSSDYCDKAFLRRKYIGSLPPEIRDVTREMPASTQRPIAASNKGHKLLSKMGWKEGQGLGKTSSGIATPVTVELRVNQSAGLGSSANHSLSLDNVHQAKKAQRWSAARQMYSKLEAQEREANRQLGLNTSQPETEHGIGYEKNQSGSREVDGPSITSTVSSDCMDLSRIPSLSLNEFSHSKALTPVTSATPSTASSKKYSSVPKISWVKGATQLPSETTENCSDSHSHNTKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A0Q2</accession>
    <name>A0A3S1A0Q2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_000764</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000011">
        <property type="protein sequence ID" value="RUS91440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A0Q2"/>
    <dbReference type="STRING" id="188477.A0A3S1A0Q2"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS91440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="231" mass="26760" checksum="5547CD210B758B06" modified="2019-04-10" version="1" fragment="single">ASGQCFNIHLDRQARGQCFNIHLDRQARGHCFNIHLDRQASGQCFNIHLDRQASGHCFNIHLDRQASGHCFNIHLDRQARGHCFNIHLDRQASGHCFNIHLDRQARGQCFNIHLDRQASGHCFNIHLDRQARGQCFNIHLDRQASGHCFNIHLDRQASGHCFNIHLDRQARGHCFNIHLDRQARGHCFNIHLDRQARGHCFNIHLDRQASGHCFNIHLDRQASGHCFNIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A1T1</accession>
    <name>A0A3S1A1T1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_000054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000001">
        <property type="protein sequence ID" value="RUS92201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A1T1"/>
    <dbReference type="OrthoDB" id="10529496at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018604891" evidence="1">
        <location>
            <begin position="22"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS92201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="101" mass="11288" checksum="A16DA3AE013D5E85" modified="2019-04-10" version="1">MLRNIFVVCLSLALLVVFTAAYSIVDEKDDIEPWMNKDPWITHVDSQTGTGGDTLSAEKRQQQPAACGYRCDCSKLTVGGCDICKYLRDLCRQRYGHVVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A4N5</accession>
    <name>A0A3S1A4N5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_009603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000277">
        <property type="protein sequence ID" value="RUS82650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A4N5"/>
    <dbReference type="STRING" id="188477.A0A3S1A4N5"/>
    <dbReference type="OrthoDB" id="6262682at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS82650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="135" mass="15819" checksum="CDFC012B3A6AD139" modified="2019-04-10" version="1">MKEKGNGEEHEIVLEEHDVEKDLERLATLKLPSLEFRRKRGDMIDLWKYIHGVYDTDRPHFDIGNSRDTRGNSLKIYKHRCRLNLPSNSFSHRVVNDWNGLPESVVTAPTVNCFKNRLDKCWENHPSLYNPQCAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A5K3</accession>
    <name>A0A3S1A5K3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_000975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000015">
        <property type="protein sequence ID" value="RUS91263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A5K3"/>
    <dbReference type="OrthoDB" id="6218661at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018719481" description="Ig-like domain-containing protein" evidence="2">
        <location>
            <begin position="32"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS91263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="584" mass="65064" checksum="00FC3911C069CB83" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1APX4</accession>
    <name>A0A3S1APX4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_023664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01002299">
        <property type="protein sequence ID" value="RUS68574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1APX4"/>
    <dbReference type="STRING" id="188477.A0A3S1APX4"/>
    <dbReference type="OrthoDB" id="6774133at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS68574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="406" mass="45235" checksum="3DEDA7BFB83F6D6B" modified="2019-04-10" version="1" fragment="single">MWKLSPDAPPISPSSKAAPSQRSLPPSPSPSSSLATIFGDVLTPESPIKLSLTPSNPPSPKPKKAPAPYPFTPEVTVERRGTGKKPAGLAPARLQKSPADTFTEKVLEAARASIPFHTNKGNRVRVPWFTTECREAIKNRKKAQRKYFNNPIPENFINFKRAIAKCRVVGHTDWGADRETLLKLYRTLVRSKLDYGSIVYGSAKKHILKTLDPIHHQGLRIALGAFRTSPVQSLYAGSGEPSLEHRRLKLSLNYAAKLNSIPENPGFESLSDSSPIEFFETKKSGPSLGARLQNHLEKLKQNENIDNVKVRKPPPWEQYNVKFDASLTEFEKGTTSAPVLQKEFLNLKEQYNEYYEIYTDGSKQDHKVAAAFFLPDDPGDSDSARLRDHSSVFSAELEAILMAMKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AQ12</accession>
    <name>A0A3S1AQ12_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">tRNA (guanine(26)-N(2))-dimethyltransferase</fullName>
            <ecNumber evidence="15">2.1.1.216</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EGW08_023528</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">EC2010</strain>
            <tissue evidence="17">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:43140"/>
            <dbReference type="Rhea" id="RHEA-COMP:10359"/>
            <dbReference type="Rhea" id="RHEA-COMP:10360"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74513"/>
            <dbReference type="EC" id="2.1.1.216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.216" evidence="15"/>
    <dbReference type="EMBL" id="RQTK01002075">
        <property type="protein sequence ID" value="RUS68709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AQ12"/>
    <dbReference type="STRING" id="188477.A0A3S1AQ12"/>
    <dbReference type="OrthoDB" id="6349953at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160104">
        <property type="term" value="F:tRNA (guanine(26)-N2)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002940">
        <property type="term" value="P:tRNA N2-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.70">
        <property type="entry name" value="N2,N2-dimethylguanosine tRNA methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002905">
        <property type="entry name" value="Trm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042296">
        <property type="entry name" value="tRNA_met_Trm1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631">
        <property type="entry name" value="N 2 ,N 2 -DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631:SF1">
        <property type="entry name" value="TRMT1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02005">
        <property type="entry name" value="TRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51626">
        <property type="entry name" value="SAM_MT_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4 15" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="12" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="372"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RUS68709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="526" mass="58926" checksum="A1D3BE7BBA2430F2" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1ARS4</accession>
    <name>A0A3S1ARS4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_021982</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001450">
        <property type="protein sequence ID" value="RUS70252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1ARS4"/>
    <dbReference type="OrthoDB" id="5877963at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015501">
        <property type="term" value="F:glutamate:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015175">
        <property type="term" value="F:neutral L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="entry name" value="Sodium:dicarboxylate symporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050746">
        <property type="entry name" value="DAACS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958:SF63">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958">
        <property type="entry name" value="SODIUM/DICARBOXYLATE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00173">
        <property type="entry name" value="EDTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="Proton glutamate symport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="524"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="556"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="605"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="637"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="679"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="715"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="748"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS70252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="798" mass="88620" checksum="F53BB150A0717284" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AVK6</accession>
    <name>A0A3S1AVK6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_018868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000944">
        <property type="protein sequence ID" value="RUS73366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AVK6"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS73366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="168" mass="17938" checksum="211394F462D37753" modified="2019-04-10" version="1">MQFYSLTSGLNVFIGTCALVILTGSSAGLAMGSFPDAEASTNSASDWFKHRWNMRSLGRGLNMLRLGKRDSISSLRLLKDLPLLRLGSVGGSSSVDGEDVDGAPVVSEQLLALLKEAVAQHAERDETRGGVRGAAPPAATALRASERRSQQANRGQRSLQPLSFRILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AWU0</accession>
    <name>A0A3S1AWU0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_017970</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000849">
        <property type="protein sequence ID" value="RUS74268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AWU0"/>
    <dbReference type="STRING" id="188477.A0A3S1AWU0"/>
    <dbReference type="OrthoDB" id="6084983at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000122">
        <property type="entry name" value="Protein crumbs homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916:SF4">
        <property type="entry name" value="UNINFLATABLE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="9"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="138"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS74268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="208" mass="22139" checksum="96FB33B7FE360042" modified="2019-04-10" version="1">MNFITLVLDVNECASSPCEHGGTCTDQVGGFSCLCPAGFSGQSCQQGQWSGERGSAEVRVWAYLGSESVQVVDEVHVPEVTSEWSEGNGSMLTVNCSFPRTPVGQLQTLLSLIVTKKRVTDRDGEEAEEVATIELEHQSQVNVLPSSSGSSSPTATTTTTTTTTTSKLSNGESVPTNTSGHINSPDSLLSLAWLSPNRFNFDFELIAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AYR6</accession>
    <name>A0A3S1AYR6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_016634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000725">
        <property type="protein sequence ID" value="RUS75608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AYR6"/>
    <dbReference type="OrthoDB" id="6083252at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS75608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="188" mass="21026" checksum="C9ABDB0203F1331E" modified="2019-04-10" version="1" fragment="single">MVFLRVLGIARLPSRLIVSLAGVNLVNTLALALHTSTVNSVLFSGNEEDCRFVGCLYHESNILFFYTLCCAIVERIIACNMASFYSRALPIIGPTVLVSPWAFWTSELLLMNAGVYDFDLGYECSSHHNLIYPHFTMATGERFAHGLALALVICLLLSILFNQQSSGDVWEINRSQFELKTTWVILKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B0Q4</accession>
    <name>A0A3S1B0Q4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_018914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000950">
        <property type="protein sequence ID" value="RUS73321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B0Q4"/>
    <dbReference type="OrthoDB" id="6151561at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS73321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="381" mass="42518" checksum="7027A7CC2146E31F" modified="2019-04-10" version="1">MAQPDTETDSEISALAASATEDSADIQLGGDEAGGETSTEASGPTVPGEIAPPPEESALDTPSVPAEIAPPPEESAQDTPMETSPESSPFANTPFPGDPPLSGTTPFPGAMRLSEDALNYSDKPLSRGMSELATHGEEKLRQSQMTSKTGTGSTGSKSGRGARRTLNDREWELRQLSTLEVVQAAEIMYYKRASVIQNPLLPPRPCRAYPKGTRPPAGSCLSIRSGPDKNRIPEEKEHYLNYRTDRSEPDMFNPNSAAATPLTARRKRRAPPKSIFLKRELGWREKEERLKNFRDHKLAEEIGYETLVGNLLYIDIPKGKDINRSWQNFLSYDVMEWGFPYYKGSKERPRIKQREPYLAHQLKEKLWRYPKTRIYHSLAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B1Q1</accession>
    <name>A0A3S1B1Q1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PIF1/LRR1 pleckstrin homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_022462</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001579">
        <property type="protein sequence ID" value="RUS69776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B1Q1"/>
    <dbReference type="STRING" id="188477.A0A3S1B1Q1"/>
    <dbReference type="OrthoDB" id="17912at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057437">
        <property type="entry name" value="PIF1/LRR1_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF46">
        <property type="entry name" value="LEUCINE RICH REPEAT-CONTAINING DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25344">
        <property type="entry name" value="PH_LRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PIF1/LRR1 pleckstrin homology" evidence="4">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS69776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="335" mass="37636" checksum="91AF6E5D9D7D77DA" modified="2019-04-10" version="1" fragment="single">MRLRCEVQVSNRQLPSLNIRKPTRPNFSQVSVGKKPGERNKDGPVYIMLCTTQNKSGTKYLIQNNVEQIFSKFAHEGKATVRIKSPPDDIALSKADPAQLSSFLRIVRMATEGRELPERVLSHLVPAATTQVTRPVETLTIDCPSRYPMVFPKTLHTLHVRHCSLRRMSPQITALTSLTVLDLSYNNLSQLPESFSNLVLLRKLDLSHNSFEAFPPVLSSESFCRSLRELDMKDNGMLALSPLFTRLSALVSINLNCNRLRYLPEQMGLMKSLAVVLVSNNLLNLLPCTLVIRAYHRADFSDNPFTVQLPPGAFVRERRKVPTLQEAAGQAVLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B5Z6</accession>
    <name>A0A3S1B5Z6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">KY-like immunoglobulin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_019343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001003">
        <property type="protein sequence ID" value="RUS72898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B5Z6"/>
    <dbReference type="STRING" id="188477.A0A3S1B5Z6"/>
    <dbReference type="OrthoDB" id="6045135at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056564">
        <property type="entry name" value="Ig-like_KY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053041">
        <property type="entry name" value="Transglut-like_Superfamily_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47020">
        <property type="entry name" value="HILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47020:SF1">
        <property type="entry name" value="HILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23265">
        <property type="entry name" value="Ig-like_KY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KY-like immunoglobulin-like" evidence="1">
        <location>
            <begin position="14"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS72898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="222" mass="25149" checksum="E42CDB168B5DC84B" modified="2019-04-10" version="1">MAERPEIPVGYLGSQPKFGELHMQTISHDDPEFSLDNNTELEIKFKCPKQIKVTTNLIHCQTDTENSEYVFTQTKDNVLSFLITFPQAGFYKFQVFALEASDESKSLPNAFNYLINVKEALKAAYPFPKQYAQWKEGCYLFSPLVLNCKTSLAKIDFKLFIPNAKAVAVVAAGEWFHLAKKDDNWEGTAALSKHRGKDVKVTVNANFGQDETKYATLLEYVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B6H6</accession>
    <name>A0A3S1B6H6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SRP54-type proteins GTP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_015004</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP-binding SRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000597">
        <property type="protein sequence ID" value="RUS77229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B6H6"/>
    <dbReference type="STRING" id="188477.A0A3S1B6H6"/>
    <dbReference type="OrthoDB" id="1727884at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005785">
        <property type="term" value="C:signal recognition particle receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14826">
        <property type="entry name" value="SR_alpha_SRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17876">
        <property type="entry name" value="SRalpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000015">
        <property type="entry name" value="Signal recognition particle receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000188">
        <property type="entry name" value="signal recognition particle receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007222">
        <property type="entry name" value="Sig_recog_particle_rcpt_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF1">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04086">
        <property type="entry name" value="SRP-alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="9">
        <location>
            <begin position="592"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="122"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS77229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="620" mass="67934" checksum="C1A46FB01315DA12" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B994</accession>
    <name>A0A3S1B994_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_009422</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000270">
        <property type="protein sequence ID" value="RUS82802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B994"/>
    <dbReference type="STRING" id="188477.A0A3S1B994"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000040">
        <property type="entry name" value="dnaJ homolog subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000013">
        <property type="entry name" value="DnaJ subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051736">
        <property type="entry name" value="DnaJ-B11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44298">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44298:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018686836" description="J domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="4">
        <location>
            <begin position="26"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS82802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="356" mass="40368" checksum="57C6553EDE325E80" modified="2019-04-10" version="1">MVASGSLVCQLAFLFVILAQVLAGRDFYKILGVSRSATTYQIKRAYRQLAKELHPDKNQDDPQAQEQFQDLGAAYEVLSDPEKRKIYDKRGEEGLKQGDTTGDPFSSFFGDFGFGFGNMREQDREVPRGGDVVMSLDVTLEELYNGNFVEVLRYKPVAKSAKGKRKCNCRMEMVTQQLGPGRFSMTQQQVCDDCPNIKFVPEEKLLEIEIEPGMRDGQEYPFVAEGEPHIDGEPGDLRFKIVQIKHARFERRGDDLYTNVTITLADALTGFEMDIKHLDGHKVHVVRDKITWPGARMRKPNEGMPNYENNNVKGSLFITFDIDFPKGVMTEEDKKGIQEILKQPSKQSVYNGLQGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B9J0</accession>
    <name>A0A3S1B9J0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_013177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000474">
        <property type="protein sequence ID" value="RUS79051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B9J0"/>
    <dbReference type="STRING" id="188477.A0A3S1B9J0"/>
    <dbReference type="OrthoDB" id="6157104at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS79051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="130" mass="15082" checksum="B2B4D52CB2576EFB" modified="2019-04-10" version="1" fragment="single">SVDIHYVTEDDFPAITVCDPNYINTRILRHVVKDNFTLFQLTKLTELPGFYHRFLHKLKGKLQVPKQENISSTDQIIRLLEFSRKVFGSPKLNPLYCSWGDFHFKEHCPGSISRLTEMGPCSTIDTRKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BC56</accession>
    <name>A0A3S1BC56_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LRRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_011648</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000383">
        <property type="protein sequence ID" value="RUS80593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BC56"/>
    <dbReference type="STRING" id="188477.A0A3S1BC56"/>
    <dbReference type="OrthoDB" id="6066926at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018760088" description="LRRCT domain-containing protein" evidence="3">
        <location>
            <begin position="28"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="506"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS80593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="567" mass="62721" checksum="0786893F99EE4851" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BEQ9</accession>
    <name>A0A3S1BEQ9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_005587</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000132">
        <property type="protein sequence ID" value="RUS86638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BEQ9"/>
    <dbReference type="STRING" id="188477.A0A3S1BEQ9"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF41">
        <property type="entry name" value="GEO08203P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="9">
        <location>
            <begin position="97"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS86638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="184" mass="20603" checksum="FF4E6B248CEB0B8E" modified="2019-04-10" version="1">MSSAMKKGICWALATLQVTHDDIDCEPAIADNQTKLPKQLPLGTKHSPNHQHQQKHCILGNIKTGGNHNQGPTTLIKDAVHSVVDTLFGREDRENVQPRYSRLDVSDHCSAESCWLVINNRVYDATRFLRMHPGGEDIILEYGGHDATTAFIEKGHSVDAFDMLAEYCIGEVIEEDRYPEVNHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BF71</accession>
    <name>A0A3S1BF71_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_005307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000124">
        <property type="protein sequence ID" value="RUS86902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BF71"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS86902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="207" mass="22082" checksum="A675B408C81CC4F0" modified="2019-04-10" version="1" fragment="single">ASLSLSPSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSLSVLIALSLGLYSDYFFFELSSVPIHPCLSVCLSVCLSVCLSVCLSVCLSVCLSVCLSVCLSVYLSIYLSICLSIYLSIYLSIYLSIYLSIYLSIYLSIYLSIYLSIYLSVYLSVCLSFCLSVCLSVCLSVCLSVCLSVCLSVCLSVCLSISLSVFCICHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BFI9</accession>
    <name>A0A3S1BFI9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TsaA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_009457</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the tRNA methyltransferase O family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000271">
        <property type="protein sequence ID" value="RUS82793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BFI9"/>
    <dbReference type="STRING" id="188477.A0A3S1BFI9"/>
    <dbReference type="OrthoDB" id="4882at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09281">
        <property type="entry name" value="UPF0066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2310.10:FF:000002">
        <property type="entry name" value="tRNA methyltransferase O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.70">
        <property type="entry name" value="YaeB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.10">
        <property type="entry name" value="YaeB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023370">
        <property type="entry name" value="TrmO-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023368">
        <property type="entry name" value="UPF0066_cons_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040372">
        <property type="entry name" value="YaeB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036413">
        <property type="entry name" value="YaeB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036414">
        <property type="entry name" value="YaeB_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00104">
        <property type="entry name" value="tRNA_TsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12818">
        <property type="entry name" value="TRNA (ADENINE(37)-N6)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12818:SF0">
        <property type="entry name" value="TRNA (ADENINE(37)-N6)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01980">
        <property type="entry name" value="TrmO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118196">
        <property type="entry name" value="YaeB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01318">
        <property type="entry name" value="TSAA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51668">
        <property type="entry name" value="TSAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="TsaA-like" evidence="4">
        <location>
            <begin position="5"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00033753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS82793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="391" mass="43502" checksum="B7834EC8E58C8D21" modified="2019-04-10" version="1" fragment="single">MNVTMKPIGTMKSLFHFKNGTPRQASVCHSAPGILTVEKTVFNNPEHSIEGLQDYSHAWVIFVFHKNNNSHTKAKVKPPRLDGKRTGVFSSRSPYRPNNIGLSLLKIDKIEGATIHFSGVDMIDGTPVLDIKPYIPEYDSPTSKLGHGTKLPLLLETGDELQEKLLDSNNIKNSIDNNTAETSTVIELEKGFLALSSALDKAGSFLASHSSKDQKDVLREESEIEITPNSSGLNTLEGSRKQHYITNDNQTVLDSHQTSATSDHVTREAAGAKNFPSASDPVIAPWLLNPPVKKLTVTFTTEALQQLQQFSKLSPDPHYQLQLLSNPKEAESAIRTVLHEDPRSVYRRQHCKDSLYFFTVDVVHITCWFDEDVAQVVRLKPVAYVSKLHAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BHK3</accession>
    <name>A0A3S1BHK3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_011358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000368">
        <property type="protein sequence ID" value="RUS80887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BHK3"/>
    <dbReference type="OrthoDB" id="6134432at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018725274" evidence="1">
        <location>
            <begin position="24"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS80887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="154" mass="16953" checksum="4817CBA7D1830E4C" modified="2019-04-10" version="1">MSLAKYSVTLMLCLGVWGFAARAHHPCGENPLRRLISVSRILSEALPDIDRDMNSILGLLRSSHPQLYRQIQDEWRSYASCVGLVDTGYFKRSSLDPSGGAGESRPKLTRAVLYQDSALSGSLGQEADLLLDILQGAIFQETDAVQEGQIEEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BJJ2</accession>
    <name>A0A3S1BJJ2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fibrinogen C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_023503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01002052">
        <property type="protein sequence ID" value="RUS68734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BJJ2"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018552322" description="Fibrinogen C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS68734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="11708" checksum="5F1EF304727065C4" modified="2019-04-10" version="1" fragment="single">MALRDLFTTARLVTLLVMASAATGLVQKQGLSIPTAHDSRSTSLILMKLERLGAKIASLENGLAGSKRSAIDSDAHDCSSTSLELLKRLDDRLGTMKYKIASLENGFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BKU1</accession>
    <name>A0A3S1BKU1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">STI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_001598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000028">
        <property type="protein sequence ID" value="RUS90601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BKU1"/>
    <dbReference type="STRING" id="188477.A0A3S1BKU1"/>
    <dbReference type="OrthoDB" id="71407at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS90601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="469" mass="51072" checksum="124681ADFD7A456A" modified="2019-04-10" version="1">MTMDVKKKSNVNLPHYLVYDCKKANAPSQWVKVNPSNVKDCLKMADDSDVPPLEDMTEIVKKADVIRESRNGPAKQNGSSNPSAKERAKVVKKPAAQVVTPNSELAKGDVSSKKPQEVKSTKQASATNPPDTGMFGGMKKGFLFGGPTKSNKTISSSLKSSSDSIKKSKENIPFITPKEKTQSALTFDEVQQAMSEAKGLMDNQDWITDDLLTKIEKNGTLRKKFADAKFMQALEEFQKDPEGAMQKYKGNEDVEKFLLDFCGLLGDHFTSMGDNPSQQKTQNSSQSVPGQSQMAKSLNDSKQFSNTVGATAKSPKIVDVTSELDASLDECSKPKPKESSSKSKSKIVELNADDDDDVSSPLSKVTLDGASSGSSGGGRVPDILTYTPGAGADIQEVSKAPLMADDEVREVLKDKRVMETLMDPQIMNIIQLLRTDPEKAQKIVDKATGDLKERITLLFMKGLLRFQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BL26</accession>
    <name>A0A3S1BL26_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Sodium/nucleoside cotransporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_022616</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001619">
        <property type="protein sequence ID" value="RUS69629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BL26"/>
    <dbReference type="STRING" id="188477.A0A3S1BL26"/>
    <dbReference type="OrthoDB" id="6075923at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005415">
        <property type="term" value="F:nucleoside:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008276">
        <property type="entry name" value="C_nuclsd_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011657">
        <property type="entry name" value="CNT_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002668">
        <property type="entry name" value="CNT_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590">
        <property type="entry name" value="SODIUM/NUCLEOSIDE COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 28 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07662">
        <property type="entry name" value="Nucleos_tra2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01773">
        <property type="entry name" value="Nucleos_tra2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter N-terminal" evidence="9">
        <location>
            <begin position="110"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside transporter/FeoB GTPase Gate" evidence="11">
        <location>
            <begin position="190"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter C-terminal" evidence="10">
        <location>
            <begin position="293"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS69629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="57269" checksum="1B4A0720FA13C29B" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BLG3</accession>
    <name>A0A3S1BLG3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FtsK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_022363</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001550">
        <property type="protein sequence ID" value="RUS69876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BLG3"/>
    <dbReference type="STRING" id="188477.A0A3S1BLG3"/>
    <dbReference type="OrthoDB" id="6742454at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050206">
        <property type="entry name" value="FtsK/SpoIIIE/SftA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018541">
        <property type="entry name" value="Ftsk_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22683:SF41">
        <property type="entry name" value="DNA TRANSLOCASE FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22683">
        <property type="entry name" value="SPORULATION PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09397">
        <property type="entry name" value="FtsK_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00843">
        <property type="entry name" value="Ftsk_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsK" evidence="4">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS69876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="236" mass="26117" checksum="67682139AFBE191D" modified="2019-04-10" version="1">MFIKMNPERAHEAPTLTKMPYIVVVADEFADMIMVVGKKVEELIARLAQKARAAGIHIILATQRPSADVVTGLIKANIPTRMAFQVSAKIDSRIMLDQQGAEQLLGNGDMLYLKPGLGAPMRIHGAFVEDDEVHRIVEKWKEYGVPEYIDSILDESEDGSDGGSNTASDGNSEDPLYNEAVEIVLKSQKASISAVQRRLKIGYNRSARLMEEMEENGIVSEMGQNGMREVLIKRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BND4</accession>
    <name>A0A3S1BND4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_004582</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000104">
        <property type="protein sequence ID" value="RUS87659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BND4"/>
    <dbReference type="STRING" id="188477.A0A3S1BND4"/>
    <dbReference type="OrthoDB" id="192544at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21464">
        <property type="entry name" value="7tm_GPR137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029723">
        <property type="entry name" value="GPR137"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15146">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN GPR137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15146:SF3">
        <property type="entry name" value="THH1_TOM1_TOM3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0458">Lysosome</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="455"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="480"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS87659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="493" mass="56309" checksum="378BAC20368810EE" modified="2019-04-10" version="1">MNQNISFSDNRTIIENTTLIGIKSNKYPDASISSRYITMEQFINTSSTIVTALTTSQQTVETTSHKMPSTTTMPIIRPALPSTVELSLTIFYFVMFSLLFILVYVQLWMIWYYRHKRLSHQTLFLFMCLVWAGLRTSLFSFYFYDCDKANSLSVFFYWLLYSFPVCLQFSMLCLLLHFFAQIVLKARTKYEAGQYKIPLRVFLSMSVVAFITLNLVFAWLTCSNDVQYRSSSLKLVTIRVILTETMFLLYGCVLSFCIYRMAKMASSHRVLEAKGTTLCQAMVTCIITTLLFLSRAVYNIITICPLTNKTTPSFGYDWINVTDQADALVGDLQHGLAYVSFGIVLFLWEVLPISMVVIFFRVRRLGTGLVPNDFSQQQHGRRVFFFDNPRRYDSEDDLSYHSGANHYPEIGARHSVNAEISRSWTPRVTPHGTPSQSLLWGVINQQDIAATNSQTVSTSATGVATDSKREGYGSFDSDPQKVQSNNNTRYDIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BPA2</accession>
    <name>A0A3S1BPA2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Replication factor C subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Activator 1 140 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Activator 1 large subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Activator 1 subunit 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Replication factor C 140 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Replication factor C large subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">EGW08_003946</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">EC2010</strain>
            <tissue evidence="19">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA. This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Can bind single- or double-stranded DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Large subunit of the RFC complex, an heteropentameric complex consisting of RFC1 and four small subunits RFC2, RFC3, RFC4 and RFC5; the RFC complex interacts with PCNA and the interaction involves RFC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000087">
        <property type="protein sequence ID" value="RUS88308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BPA2"/>
    <dbReference type="STRING" id="188477.A0A3S1BPA2"/>
    <dbReference type="OrthoDB" id="446168at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="18">
        <location>
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            <end position="651"/>
        </location>
    </feature>
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    <feature type="region of interest" description="Disordered" evidence="17">
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        <location>
            <begin position="1222"/>
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            <begin position="10"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
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    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00054501"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00064311"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00075134"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00076017"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00077727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00078526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00080382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RUS88308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1275" mass="139390" checksum="10FADB8747C13A4E" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BPF8</accession>
    <name>A0A3S1BPF8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Heat shock 70 kDa protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_003872</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000085">
        <property type="protein sequence ID" value="RUS88360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BPF8"/>
    <dbReference type="STRING" id="188477.A0A3S1BPF8"/>
    <dbReference type="OrthoDB" id="29851at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10238">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000010">
        <property type="entry name" value="heat shock 70 kDa protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042049">
        <property type="entry name" value="HSPA14_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS88360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="506" mass="55060" checksum="7548692D566FD746" modified="2019-04-10" version="1">MAAFGLHIGTCSGCLAVYRDGKTNVVANDLGDRVTPCVVAFTEHETIVGAAAKQGIIRNASNTVCHVKRLLGCSPDDPLVAEYSKTSSVNVVNHNGVLMFEVNHRGKPAKFSPTDILKTIYKKMLETAQSHGGSGIQDAVLAVPPDFDTNQRNLVTDAATKAGFNILRVITEPSAALLAFDVGQLDQTEGFKTLVYRLGGTSHEAVIMEVEHGMYRTVAKVSDSQFGGDFFTEALQRFLMSEFNRQSRCDMKDNKRSVAKLGLAAERCKHSLSTMLTAQCAVDSLYDGCDFHYNMSRARFDSLCQPLLFKCTALIEQVLGEARCTKEDISKLIICGGGAKPPIVKKAICDFLPNATRLDSVPEDEIIAIGAAKQAALLVGGVESENIGIDKESSLINFKFLPKAVCIKTSNEELEVVLPQHSLAPSRRQHTLTLAQAQTDVALEIFQTDDPAKLETSELLAKLIMRDLPPGSTIKSNFHLKREGDLHITCHEVTSDKYESVTIPCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BPR3</accession>
    <name>A0A3S1BPR3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_003770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000081">
        <property type="protein sequence ID" value="RUS88512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BPR3"/>
    <dbReference type="STRING" id="188477.A0A3S1BPR3"/>
    <dbReference type="OrthoDB" id="8170117at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.30:FF:000001">
        <property type="entry name" value="MOB kinase activator 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS88512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="216" mass="25124" checksum="94059351B86AEF9B" modified="2019-04-10" version="1">MSFLFGSRSNKTFKPKKNIPEGTHQYDLMKHAAVTLGSGNLRQAVQLPDGEDLNEWVAVNTVDFFNQINMLYGTITEFCLEETCPVMSAGPKYEYHWADGQTIKKPIKCSAPKYIDYLMTWVQDQLDDEALFPSKIGVPFPRNFLSIAKTILKRLFRVYAHIYHQHFKEVVQLSEEAHLNTSFKHFIFFVQEFNLIDRKELAPLQELIERLTSKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BU08</accession>
    <name>A0A3S1BU08_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_017374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000792">
        <property type="protein sequence ID" value="RUS74867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BU08"/>
    <dbReference type="OrthoDB" id="6156466at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043:SF8">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="6"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="43"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="98"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="144"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS74867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="178" mass="18638" checksum="17D81E420EE53E84" modified="2019-04-10" version="1" fragment="single">GYFGSNCVQRCGHCLDGAVCDPASGACPWRCQPGWSGIMCDTECSSGFHGQNCDFSCGHCRDGSVCLRSTGVCPQGCEAGFQGLFCTKGCMSGKWGPDCHSTCGQCFHGRCHNVTGECDPPGCLPGWDGPRCDADCPAGTYGMNCSNRCGHCQGTCQPLDGRCSAHCKPGWAGPMCLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C048</accession>
    <name>A0A3S1C048_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_012886</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000456">
        <property type="protein sequence ID" value="RUS79365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C048"/>
    <dbReference type="STRING" id="188477.A0A3S1C048"/>
    <dbReference type="OrthoDB" id="10059338at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480:SF1">
        <property type="entry name" value="TYR RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS79365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="195" mass="22371" checksum="B1421CF207D54055" modified="2019-04-10" version="1" fragment="single">LESCPHEISTKKGVCTAVKTASNHSDTSLDTNPHLRPFDDLPDDAIVRRAVSRNGASVLDKKQYCYFCHKPQLKLARHLTTIHKDARAVARLLAVKQSKHEEYLIGLKKLKCIGNFIHNVESIKLNKPDIVVKRPTKSRSVAEYLPCVHCYGFYVREELWKHTKNCEINNSNDEKDLLDTLCIFCKTLRSFLYVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C7H6</accession>
    <name>A0A3S1C7H6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_007256</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000186">
        <property type="protein sequence ID" value="RUS85011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C7H6"/>
    <dbReference type="STRING" id="188477.A0A3S1C7H6"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20041">
        <property type="entry name" value="FH_dFKH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000042">
        <property type="entry name" value="hepatocyte nuclear factor 3-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047388">
        <property type="entry name" value="FH-like_dFKH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013638">
        <property type="entry name" value="Fork-head_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF380">
        <property type="entry name" value="PROTEIN FORK HEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08430">
        <property type="entry name" value="Forkhead_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="6">
        <location>
            <begin position="150"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="4">
        <location>
            <begin position="150"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="250"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="416"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="457"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS85011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="527" mass="57288" checksum="75A1475FF8664242" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1CGA0</accession>
    <name>A0A3S1CGA0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">acetyl-CoA C-acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EGW08_000418</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">EC2010</strain>
            <tissue evidence="16">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="5"/>
    <dbReference type="EMBL" id="RQTK01000005">
        <property type="protein sequence ID" value="RUS91847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1CGA0"/>
    <dbReference type="STRING" id="188477.A0A3S1CGA0"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000007">
        <property type="entry name" value="acetyl-CoA acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF156">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0630">Potassium</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="14">
        <location>
            <begin position="30"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="15">
        <location>
            <begin position="295"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="12">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RUS91847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="411" mass="43084" checksum="644648F4AB07B31E" modified="2019-04-10" version="1">MPALRILHSQIFKSCANARTFTQSSGLEDVVIASAVRTPIGSFMGSLSSLPATKLGSVAIAGAIDKAGIAPEAVGEVYMGNVLQGGQGQAPCRQATLGAGLPITTPTTTINKVCASGMKSIMLAAQNLMCGHQSVMVAGGMESMSNVPYYVRRGATPYGGFKVEDAIVADGLTDAYNHCHMGNCAESTAKKFSIGREEQDEYAVRSYQLSQKSAKDGLFKAEIVNVTVPQKRGDPTIVSEDEEYKKVNFDKFKTLRPVFQKEGGTVTAANASTLNDGAAALVLMTAKAAEEMKVKPLARILGFADAAIDPMDFPTAPAHAIPKMLQRCGVKVEDVSMWEINEAFSVVVLANMKMLGLDINRVNVHGGAVSIGHPIGMSGARITGHMAHTLKKGQYGVAGICNGGGGASAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H2R9</accession>
    <name>A0A3S1H2R9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_021167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001278">
        <property type="protein sequence ID" value="RUS71063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H2R9"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS71063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="138" mass="15072" checksum="F5F8D470AD77B173" modified="2019-04-10" version="1" fragment="single">AVIQEQVELVSDLPWVPSRGWCHYTPPNVNAEFVNRESLAVPKLFFRACNLPKSSSNMESGFSEWSSPIQTSGNTDAFIQLRGFCDLKVAIETVGMVTHLVIRPVSKAEVSAREIRSRLKGSRSDHVAVAGASGGDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H4N5</accession>
    <name>A0A3S1H4N5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_020141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001114">
        <property type="protein sequence ID" value="RUS72096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H4N5"/>
    <dbReference type="OrthoDB" id="10594190at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS72096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="701" mass="75737" checksum="19A32F893194B8C3" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H8T2</accession>
    <name>A0A3S1H8T2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_017818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000832">
        <property type="protein sequence ID" value="RUS74424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H8T2"/>
    <dbReference type="OrthoDB" id="6161632at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS74424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="332" mass="37026" checksum="DF5EE7600F63D145" modified="2019-04-10" version="1" fragment="single">PSNSTFPREINNGTVISDTREHFHRATSILIGDSFKRFEDEQTPNFSNQSITFSQVLCNNPQGLNSSSHTLNDSSQDLFINTEDARLDSFQTLNDSSQDLFINTEDVSLDISQTMNDSSKDLLNDTDARPNYSQTEKECTMNTHDFVRYILDCTPAAVEHATLPESVSTAGNVPMSAPSVPDHDVGEEDCPSEDDIGGGKDEEDRDPSYNPHGASNENSEGETDSSDSEDDCPITDAQPILPEYDTPIAPAISPDNRMQSTHPGRNTTRKRVRDEADWKTNIRKKQRNNGKEYVTRKGKQVREKSLKDTKCGCQSNCNGKISFQTRQEIFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HST5</accession>
    <name>A0A3S1HST5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_006805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000170">
        <property type="protein sequence ID" value="RUS85414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HST5"/>
    <dbReference type="STRING" id="188477.A0A3S1HST5"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS85414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="141" mass="17987" checksum="9F3042E76AA56F28" modified="2019-04-10" version="1" fragment="single">LFSYIAYRFISYIAYRFVSYITYRFISYIAYRFISYIAYRLISYIAYRFISYIAYRFFSYIVYRFISFIAYRFISYIAYRFISYIAYRFFSYIAYRFISYIAYRLISYIAYRFFSYIAYRFISYIAYRFFSYIAYRFLKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HZR2</accession>
    <name>A0A3S1HZR2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_002827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000057">
        <property type="protein sequence ID" value="RUS89390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HZR2"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS89390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="233" mass="25226" checksum="BB38F6F1177B3399" modified="2019-04-10" version="1">MSSSSSSYDGDTQSDVISGGADSAFWEGPASLLDGSPREQRGEGQKVKVIENNFDAEGHAEAPIYKRIQRDRDGNNQGQGQGQGRKVRFVEEGYSYRAARKMKPDRDKKRGSRNGKRRRASRRGGGSKNKLVISGDGGRNSDLTSSDDDEEGGGLAARCISLALGPSQNTVSLVGFRSLPVDPGPFRSFPETPSVYGADSPLILALFGVSPRLRLFMEQTQTIRACIEARLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SJD9</accession>
    <name>A0A433SJD9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome-recycling factor, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ribosome-releasing factor, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_023086</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001803">
        <property type="protein sequence ID" value="RUS69158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SJD9"/>
    <dbReference type="STRING" id="188477.A0A433SJD9"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002184">
        <property type="term" value="P:cytoplasmic translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.20:FF:000001">
        <property type="entry name" value="Ribosome-recycling factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="entry name" value="Ribosome-recycling factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982:SF3">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME RECYCLING FACTOR PSEUDO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="RIBOSOME RECYCLING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="Ribosome recycling factor, RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome recycling factor" evidence="7">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="53"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS69158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="106" mass="11883" checksum="E332B5BC3C9786F8" modified="2019-05-08" version="1" fragment="single">KAIMSSDLGLNPTNLGDTLRLPLPALNEERRRELVKVVKSEAENGRISIRNIRRDANSDIKELLKEKEITEDEAKKAEENVQKVTNAMIAEADALAVKKEQDLMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SK71</accession>
    <name>A0A433SK71_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_022817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001689">
        <property type="protein sequence ID" value="RUS69419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SK71"/>
    <dbReference type="STRING" id="188477.A0A433SK71"/>
    <dbReference type="OrthoDB" id="6120255at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="394"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS69419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="469" mass="51271" checksum="38304792FA924A2F" modified="2019-05-08" version="1" fragment="single">LVPSNNYEYEGEEEEDEPEYAVVHKRRGDSTYRPQTNAENTLGARASHVGSDDYSTSGAMPPEPPRLFNAYEDEEEEETYSVTSPTDEKKEHRYSRVTARESLASMSARNALNPYELVNDMPENMYATVEGGSGDGIVLRHMDSDDNNSNRNSQNSDTYAEIAVSGSGGFRSSTISNNNNSSNINMGSTNNSSNNSNANNASMNNASGASSGAPDPPSLDSLHLMTKSQTSSEDDRLSDRHLASPEDSGFDATGFPRLPAWGSRTFMQGDEDSGGSIAEDGYSTLKRVVDAGARGAERESLVPPDQLGQMTVRDEESGEVTQLSQGYSRVKDHIRQADLEKEMENDPNYESVDEARAKLRLLYKTEKRIGEENDDAGNSSNRNHVTVVEVLHSVKTSTVSSSSKMQRASSNMHTPPSPPPHSNVKTKNASTEDKEMLKKRSDGKPRRRPNHDYEELDLSPPTSPTAAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SMZ5</accession>
    <name>A0A433SMZ5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_021640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001373">
        <property type="protein sequence ID" value="RUS70594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SMZ5"/>
    <dbReference type="STRING" id="188477.A0A433SMZ5"/>
    <dbReference type="OrthoDB" id="6140595at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS70594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="265" mass="29423" checksum="2AD18FDE1D6B0D53" modified="2019-05-08" version="1">MQINWSGDGSAEKAVRNGGAGIYIKYPGGEEDKISIPTGVFSTNYKAEATAIQEGAAHVQSSPHSTKNIVFLTDALSVLQALKSSKNKDLNDLTSALTSLSQTHTIALQWIPSHCNVFGNETADLLAKKAAALQQNDYTTTYSEAKTIIHAQQHEEWLQEHPNHVQNDAYHALTRAEQVVIFRLRTGHNRLNHHLYTKLHIGTSDQCTCQTGGQTVIHVLQHCPMYENLRNLMWPQDTPMAQKLYGSLEDLRRTATFMSETGLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SMZ9</accession>
    <name>A0A433SMZ9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_021685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001382">
        <property type="protein sequence ID" value="RUS70556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SMZ9"/>
    <dbReference type="STRING" id="188477.A0A433SMZ9"/>
    <dbReference type="OrthoDB" id="6040964at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.75.10">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036645">
        <property type="entry name" value="Elafin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00095">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00217">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57256">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51390">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WAP" evidence="2">
        <location>
            <begin position="345"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS70556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="539" mass="57193" checksum="746F1AE5395E7002" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SQA3</accession>
    <name>A0A433SQA3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_020829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001217">
        <property type="protein sequence ID" value="RUS71408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SQA3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS71408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="454" mass="49510" checksum="BF83548416D1A865" modified="2019-05-08" version="1" fragment="single">MKAKPATRSGSPAMSPSPKSPSKSSTRLPIKMGSKSPSKTVGKPTTNASPTKTTTKTPVKELPSQAKKTAKAPMKDSTKSPAKSKSPTPGAKPTAKQQQKTADKKPVKESPEKSKAGNERQGSQNRGKSPRPDAKASSSKGSQTAKGKIAIKQRETKILNLKAKADSPSKKKPQTVLGNNKKTPLKKTPSKIVQKAKKKKIERELSTSQFIDLWTLANIGKREASLNASMKVNIMYESVAKSPPKSAPTKPSTDAEEVKGKAQQDKSTPKKSTPENKDKTAETDEKKTKRPMLRVCKCKATKGKKLAVSAALKVHKKSVMSSPSKTGQTELRKRKSPHYKIFKEEPIAKSRKVEDKKAKLAVKSKAKTTNGTSKKKKPKAAPSGHQLCNIIEKSPRQASLIAKAMIALEQEEDVVLESTARTKVYDWKELRPHHQNSRRRLVWVSGLAKSITDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SR49</accession>
    <name>A0A433SR49_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_020530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001172">
        <property type="protein sequence ID" value="RUS71703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SR49"/>
    <dbReference type="OrthoDB" id="43807at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026728">
        <property type="entry name" value="BLTP3A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22774">
        <property type="entry name" value="CHOREIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22774:SF11">
        <property type="entry name" value="CHOREIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24917">
        <property type="entry name" value="BLTP3A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS71703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="163" mass="18207" checksum="6E8F4B6065D68E3E" modified="2019-05-08" version="1" fragment="single">NLYVLVNPVRVTLDFLTLLWSNVFLLTLSNSLDMDFGEQKPPEHADIKVEMLMPRVIIPAEEKVENQPDRPEAVQVQVSKLVLTNGRTEDGMTRTDLLTTLDMYGRAGLFASPEFPNQGGQGHRGVKGEVIPDFLYQHAEDCDDPYIDTAIKALLSHVKAEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SSZ6</accession>
    <name>A0A433SSZ6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_019862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001074">
        <property type="protein sequence ID" value="RUS72382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SSZ6"/>
    <dbReference type="OrthoDB" id="6041441at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019347174" description="EGF-like domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS72382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="25093" checksum="EF13B6BD2216A233" modified="2019-05-08" version="1" fragment="single">MDARISLLVFVLGISIGVVCSQIVITSGESGELCGTYHRCLSNSTCLRAKGNFLCACPEPLTGNAKLGCVSKESATVYIQNDPHMKNLFRQFLTVSTPCRYRVMEFYSDNLYVVRVYVEHLMYKGGNFYANQISVQMAKSSEYFTSEPDASKLTWSSVSIIGDTVSQGHYEFREWRSVLALPDGIEMYTEYDETNNLAIIKAPGVGLKVWLRPLDRHALQEDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433STU2</accession>
    <name>A0A433STU2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_019662</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001050">
        <property type="protein sequence ID" value="RUS72576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433STU2"/>
    <dbReference type="STRING" id="188477.A0A433STU2"/>
    <dbReference type="OrthoDB" id="6151988at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11410">
        <property type="entry name" value="bHLH_O_HES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050370">
        <property type="entry name" value="HES_HEY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10985">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="5">
        <location>
            <begin position="28"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS72576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="101" mass="11666" checksum="6E9A4153314CCDA8" modified="2019-05-08" version="1" fragment="single">MAMDRPTFTNICEATSQSHELDNMRPIHRKGKKLLAEKKRRARINNCLVQIRDLVCEGEDEKDSDIDKMEKAEILEKTLEVLTRFRREYNTSGFSSCSGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SVL9</accession>
    <name>A0A433SVL9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">STIL N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_018877</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000945">
        <property type="protein sequence ID" value="RUS73358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A433SVL9"/>
    <dbReference type="OrthoDB" id="76173at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031023">
        <property type="term" value="P:microtubule organizing center organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071539">
        <property type="term" value="P:protein localization to centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026123">
        <property type="entry name" value="STIL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057731">
        <property type="entry name" value="STIL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15128:SF0">
        <property type="entry name" value="SCL-INTERRUPTING LOCUS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15128">
        <property type="entry name" value="TAL1 SCL INTERRUPTING LOCUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15253">
        <property type="entry name" value="STIL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STIL N-terminal" evidence="2">
        <location>
            <begin position="12"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="696"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="827"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="939"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1281"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="544"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="654"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="696"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="743"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="760"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="827"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="867"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="979"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1316"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1342"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS73358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1358" mass="147691" checksum="FF5968C50E1B72F4" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SVX1</accession>
    <name>A0A433SVX1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_018835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000941">
        <property type="protein sequence ID" value="RUS73396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SVX1"/>
    <dbReference type="STRING" id="188477.A0A433SVX1"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF130">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="90"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS73396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="221" mass="25328" checksum="8E53839BB064BD4D" modified="2019-05-08" version="1">MAQNDPSKISGEILEKAKKELNEDPQTRLIEVKNLAKRLQKVPGKKPRLDYPFLIKFLRARKFEQERAFQLVKSYYDVRRTQKDIFDDLKPSRVKHILDAGVIEVLPGTDADGATVIVLRVGRISLQDDAVYVLKITGLMEKFSKEEIQVNGIHIINNMEGITMKHASHIGPSVAKTIASVIQNVVPMRFKRLDYVNEPSFFDLIFGLIKQFLKEKILKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SYK1</accession>
    <name>A0A433SYK1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_017844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000835">
        <property type="protein sequence ID" value="RUS74389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SYK1"/>
    <dbReference type="STRING" id="188477.A0A433SYK1"/>
    <dbReference type="OrthoDB" id="1702031at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.950">
        <property type="entry name" value="Methyl-accepting chemotaxis protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58104">
        <property type="entry name" value="Methyl-accepting chemotaxis protein (MCP) signaling domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS74389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="230" mass="26136" checksum="BF7E4A3D9509A104" modified="2019-05-08" version="1">MTRSVDSIKRNSHTMRRFVDGIKRNPQTMTRSVRDIKRISETMTRTVGDIKRNSQTMTRSVDGIKRSSHTITRSVDGIKRNSQTMARSVHDIKRNFQTMTRSVDGIKRNSHTMRRFVDGIKRNSHTMARSVHGIKRNSHTMTRSVDGIKRNSQTMTRSVGAIKRNSHTVTRSVDGIKRNSHAVARSVGGIKRNSHTMTRSVDGIKRKSHTMARSVGGIKRNNSPKEEECV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SZI4</accession>
    <name>A0A433SZI4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aminomethyltransferase</fullName>
            <ecNumber evidence="11">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_017661</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[protein] + (6S)-5,6,7,8-tetrahydrofolate = N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the GcvT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="11"/>
    <dbReference type="EMBL" id="RQTK01000818">
        <property type="protein sequence ID" value="RUS74580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SZI4"/>
    <dbReference type="STRING" id="188477.A0A433SZI4"/>
    <dbReference type="OrthoDB" id="10263536at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.110:FF:000002">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.120:FF:000014">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1400:FF:000001">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1250.10:FF:000002">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1250.10">
        <property type="entry name" value="Aminomethyltransferase fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GcvT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001567">
        <property type="entry name" value="PRK00389.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF16">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006487">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GCVT N-terminal" evidence="12">
        <location>
            <begin position="39"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="13">
        <location>
            <begin position="321"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006487-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS74580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="407" mass="44393" checksum="496CFE60CAEF64AE" modified="2019-05-08" version="1">MAHIRFGLKNLRDVLNTVGGRSVSKRFLAQDAELKRTALYDFHLAEGAKMVPFAGWEMPVKYKGGITEEHLHVRQQVGIFDVSHMLQTRVEGKDRKEFMEKMVVTDIQALQDNQGTLTVFTNDQGGILDDLIINNTDKDYLYVVSNAGCADADLAHMKATEASFKKSGGDVKLSVIENALLAVQGPQMVSVLQPGVDFDLKNLPFMTTTEGKVFGVDGCRITRCGYTGEDGVEISVPQSGAEKLLASLLGSSQASVKLIGLGARDSLRLEAGLCLYGNDIDATTSPVEANLTWLVSKTRRQKLDFPGAEIIVDQIKKKPSKRRVGFVSSGAPIRGHAKIFSEDGSELIGETTSGCPSPSLKVNVSMGYVKTPFAKNGTKVKIEVRKKMIEGEVSKMPFVPSKYFILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SZX2</accession>
    <name>A0A433SZX2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_017387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000794">
        <property type="protein sequence ID" value="RUS74830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SZX2"/>
    <dbReference type="STRING" id="188477.A0A433SZX2"/>
    <dbReference type="OrthoDB" id="10066265at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS74830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="27935" checksum="63BC0E6FB2359FC7" modified="2019-05-08" version="1">MLKRLCNEKPKQWHRYINALLFAYREVPQESTHFAPFELMYGRTVRGPIHILRKLWTQDIDEPEVKSSYQYVLDLRERLTDTLELAKKQLESSQARQKKHFDKKTKSRCFRPGDKVLVLLPTDTNKLLVQWKGPYDIIKSVGLNDYKVKINGKEKTLHANLLKKYLSRNDETCSTVLDVSSHIRDDLNVPSCVAVVEDYDYDADNDQDNPADGEQGSEDLPEIGTWGQKEDAADVKSSRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T1P1</accession>
    <name>A0A433T1P1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_016789</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the importin beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000742">
        <property type="protein sequence ID" value="RUS75439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T1P1"/>
    <dbReference type="STRING" id="188477.A0A433T1P1"/>
    <dbReference type="OrthoDB" id="760868at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000813">
        <property type="entry name" value="D-Importin 7/RanBP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058669">
        <property type="entry name" value="TPR_IPO7/11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF18">
        <property type="entry name" value="D-IMPORTIN 7_RANBP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25758">
        <property type="entry name" value="TPR_IPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="22"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="878"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="882"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS75439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="928" mass="106298" checksum="E7FA8F28FDE43FFB" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T3X4</accession>
    <name>A0A433T3X4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_015995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000678">
        <property type="protein sequence ID" value="RUS76252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T3X4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS76252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="207" mass="26386" checksum="B9D2EE15AE6C39B1" modified="2019-05-08" version="1">MQYKHRRQALQYKHRRQAMQYKHRRQALQYKHRRKALQYKHRRQALQYKHRRQAMQYKHRRQALQYKHRRQAMQYKHRRKALQYKHRRQAMQYKHGRKALQYKHRREAMQYKHGRKALQYKHRRQAMQYKHRRQAMQYKHGRKALQYKHGRKALRAHLPGRRYHYFHFQLEGYKIMCNREANTNNKRTQLTISLDQLTLLPTFKTFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T499</accession>
    <name>A0A433T499_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_015876</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000669">
        <property type="protein sequence ID" value="RUS76346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T499"/>
    <dbReference type="STRING" id="188477.A0A433T499"/>
    <dbReference type="OrthoDB" id="6154617at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS76346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="323" mass="36214" checksum="4DD9A09FF48D1668" modified="2019-05-08" version="1">MRPGVSAKASIFTAEAVALCMALDSVSTSRKDTFLILSGSLSLVKVVGEANSKNPKIIINIKILEQIHEIQKNGKKIVLSWIPSHVGIKGNEIVDELAKIGLELEPTQMQIPASDAKPNIHTFIRENWKARWNNMTSNKLHCVQPHLGHWPGISQARRRDQVVLDRVRLEHSHLTHAFLLRGEEPPLCQTCNCELSILVDCPFFYQGRNLYLASKPLESIFTYLAHFMAASNSKTPSPISEKAQTLHKFNYTEEWKTKETEMDNAASKQSPSVKTFLDPESALPQPPPPPPLPPPFLKSNDSQGQQITRLDPNCVTWMKKCLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T5W0</accession>
    <name>A0A433T5W0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_015294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000622">
        <property type="protein sequence ID" value="RUS76945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T5W0"/>
    <dbReference type="STRING" id="188477.A0A433T5W0"/>
    <dbReference type="OrthoDB" id="10015857at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS76945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="328" mass="37506" checksum="B32DF43A02901FAA" modified="2019-05-08" version="1">MASAYLGPEIHRPLSVISESYQNRLKIPALGEEERYRFGQMYEQKMFSLLHEHLELGTTDKLVYVGDTKGSMSEAIEEKFCLVHPVQTVIPGHFHFAETEGGAKMLPIRIAHVGAEEFFRTLAENTSPDKPKYDRILIDDCVRYLAEPRVTYKNMVASLAPQGRLLLIHRPGDLSTLPYFSDARQRLSDNEIAYSDIIRDLQACRLDVSWELECLPVRMPKRKWLAMLRERYPTQTEILSQVEVVSGIRELSEGVLKYEGDMVEFIDRQLFISATPCRLPKGIPSVTRGGAELDPSPAHTLPPLKYVMKICPDQLKELRRKPDDDLFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T659</accession>
    <name>A0A433T659_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gastrin/cholecystokinin type B receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Cholecystokinin-2 receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">EGW08_015195</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">EC2010</strain>
            <tissue evidence="19">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000615">
        <property type="protein sequence ID" value="RUS77038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T659"/>
    <dbReference type="STRING" id="188477.A0A433T659"/>
    <dbReference type="OrthoDB" id="10037617at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015054">
        <property type="term" value="F:gastrin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009126">
        <property type="entry name" value="Cholcskin_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000314">
        <property type="entry name" value="Gastrin_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238:SF75">
        <property type="entry name" value="CHOLECYSTOKININ-LIKE RECEPTOR AT 17D1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01822">
        <property type="entry name" value="CCYSTOKININR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00527">
        <property type="entry name" value="GASTRINR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 16" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 16" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="18">
        <location>
            <begin position="96"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RUS77038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="424" mass="47455" checksum="B36207B0B2BCBB5B" modified="2019-05-08" version="1" fragment="single">MGDNSSLATRLSDAFTPTTIASNLQNMMAAANISNLGSLWGVNESDINTENNNINNNIPFNNVNNRTNGSMGGNNNNFLMAQIPFYGLIFVLSVVGNILVIVTVIQNKKMRSLTNVFLLNLSLSDLLLTLFCMPFTLVPVYLRDFIFGEVMCVLVRYMQGVSVATSCFTLVAISLERYFAICHPLKSRRWQTLSHSYKAIAVCWLCALALSVPIAIHHVYSEIGTTGRHSCREIWPSVESEKAYTVALDLLLLVLPVLIMTWAYGCKVSQQQKSCRGGGGNGLYSCNNDTSSSLINNSSSGNGNGKSSQSLKSSAEPIVASKPFRRFDAHRAMRQSNTERSRAAKKRVIKMLFIIVLEFFIFWTPTYVIYTWYVFSFQTARKHVSPEMKSLFHLLSYVSTCCNPITYCFMNKNFRDSFLVAFRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T6F5</accession>
    <name>A0A433T6F5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_015114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000608">
        <property type="protein sequence ID" value="RUS77127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T6F5"/>
    <dbReference type="OrthoDB" id="10648146at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS77127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="340" mass="35627" checksum="31F2984ECE8C9D03" modified="2019-05-08" version="1">MPEVEELDDACVEKAFNIVDNGYGHQHESTIPNSTLATINSTVSALGATGIINTTVFNDTARALIANDTFEAILRNLTASVLSIDGDYKSLRYANSANNYTVFNHTTSSILKTIIPFNSSTSSSYLSSSLSFTTAATITSPTTTPGGAIMTPHDLRDFPLNDSSPVSSVTSSLETLLQNLTGVTADIGSAALDPNSTPFSYTDGGFSAPLENAGDTTFNKDFSGERGTKIVQSTAASHPNTKQTDLVAGTSVKASSPSTGSPVSNYYVNLSTTFYDLVNASQSGTSSVVHDPALTNLLSTPPSSNNTTMAAGGVDCSRTLLLLRTALHRTEVRVVVVELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T751</accession>
    <name>A0A433T751_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fibrinogen C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_014842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000584">
        <property type="protein sequence ID" value="RUS77396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T751"/>
    <dbReference type="STRING" id="188477.A0A433T751"/>
    <dbReference type="OrthoDB" id="6275059at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF458">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS77396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="108" mass="12416" checksum="F3D228AA5A380338" modified="2019-05-08" version="1" fragment="single">QYPPYVVMAHDGPKEEILCDTHTDGGGWIVIQRRAKGDVDFYRDWTSYRDGFGSLTGDFWIGNEAIHKLTDAHPYELRIDARHEGKELFAEYSSFRISGEEDNFSLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T7Y3</accession>
    <name>A0A433T7Y3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_014535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000559">
        <property type="protein sequence ID" value="RUS77699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T7Y3"/>
    <dbReference type="STRING" id="188477.A0A433T7Y3"/>
    <dbReference type="OrthoDB" id="7472369at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS77699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="118" mass="14076" checksum="9B621CFD9D5750CD" modified="2019-05-08" version="1">MLAVTHKKAERVVTTETQIELRQFANTELRQFANTELRQFANTELRQFANTELRQFANTELRQFANTELRQFANTELRQFANTELRQFANTELRQFANTELRQFANTELREFANTELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T8D9</accession>
    <name>A0A433T8D9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_014378</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000546">
        <property type="protein sequence ID" value="RUS77865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T8D9"/>
    <dbReference type="STRING" id="188477.A0A433T8D9"/>
    <dbReference type="OrthoDB" id="10249245at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11286">
        <property type="entry name" value="ADF_cofilin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="3">
        <location>
            <begin position="2"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS77865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="153" mass="16888" checksum="1A0DF996CBDCB90E" modified="2019-05-08" version="1">MASGVKVVDDVKLAFSNVSINSSSKKKEKLKYGIFKFSEDATQIVVDSTGKKGESENWEYDKLVQNLPANDVRYVAYDFEFLKMDGTPNSKVILVSWCPETSPIKKKMLAASSFNSLKTALGNPDKYLEGDCLSEVDTKAVLDKLQAKEGCNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T8E6</accession>
    <name>A0A433T8E6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_014423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000550">
        <property type="protein sequence ID" value="RUS77806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T8E6"/>
    <dbReference type="OrthoDB" id="6038736at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS77806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="184" mass="21608" checksum="F979765CA4CE66AC" modified="2019-05-08" version="1">MSDRFLSTSKGPAFCKYATSKGQNLFERGYWNPMPVNTYLTGDGLSHTYRGSGYYVPSERAWIDYKDYRSLPPLARRDAKHMDSEDKYREFQKRRDSRPNPSGISMSGYPMNFTGVPYPQLVPFHTDAWRRRWNGPGNLVPPSDKWVHENPGSQYNAYKFYNEEDFDKFKHMNQGICTVEKIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TD47</accession>
    <name>A0A433TD47_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">asparaginase</fullName>
            <ecNumber evidence="1">3.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_012885</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="RQTK01000456">
        <property type="protein sequence ID" value="RUS79364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TD47"/>
    <dbReference type="STRING" id="188477.A0A433TD47"/>
    <dbReference type="OrthoDB" id="542841at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009066">
        <property type="term" value="P:aspartate family amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08963">
        <property type="entry name" value="L-asparaginase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1170:FF:000003">
        <property type="entry name" value="60 kDa lysophospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="entry name" value="L-asparaginase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027475">
        <property type="entry name" value="Asparaginase/glutaminase_AS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041725">
        <property type="entry name" value="L-asparaginase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707:SF28">
        <property type="entry name" value="60 KDA LYSOPHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500176">
        <property type="entry name" value="L_ASNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00057">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00917">
        <property type="entry name" value="ASN_GLN_ASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="L-asparaginase N-terminal" evidence="4">
        <location>
            <begin position="42"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase/glutaminase C-terminal" evidence="5">
        <location>
            <begin position="274"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="418"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS79364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="457" mass="49819" checksum="7B73E5346A0373A2" modified="2019-05-08" version="1" fragment="single">MSAESETNGGASSLSADTVEGIHSSAACYRQGSLSSQRDSTVLVIYTGGTIGMVNLNGSYQPLANCMISKLRSLPIFNSAAIQQQGSKEENEDSFLVLQSSAASPRRVAYKIIEFDPLLDSSNMAISDWIKIAECIKENYEEYDGFVVLHGTDTMAYTASALSFMLENLGKPVILTGSQIPIYESRSDGRNNFLDSLIIAGTCAIPEVVMICFFERVYRGNRCIKSDAESFSAFASPNMSPLVQLQVKIKVDYSSIFRQGSEDKFCISTNMCPNVGLLRLFPGITIQTVRAFLHPPVQGVVLQTYGAGNAPNNRPDLLSLFKEAYNWGVIIVNISQCTKGNVGASYATGAEVLKVKDALYPCLMSAAAKANDIPALEKLRVTNFNFLLADLLNQFAPPLNMVHYLLNHGVSVHARDCRRETPLYDAVSRGHLDIIRVLTQTGASLHLSVVDMAVKMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TEM9</accession>
    <name>A0A433TEM9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SOCS box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_012222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000415">
        <property type="protein sequence ID" value="RUS80014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TEM9"/>
    <dbReference type="STRING" id="188477.A0A433TEM9"/>
    <dbReference type="OrthoDB" id="6121651at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34226">
        <property type="entry name" value="PROTEIN CBR-ABU-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34226:SF1">
        <property type="entry name" value="PROTEIN CBR-ABU-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="312"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="540"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="568"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="397"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="632"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="453"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="682"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS80014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="929" mass="102865" checksum="88DD21C19477668D" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TFC0</accession>
    <name>A0A433TFC0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_011975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000402">
        <property type="protein sequence ID" value="RUS80246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TFC0"/>
    <dbReference type="STRING" id="188477.A0A433TFC0"/>
    <dbReference type="OrthoDB" id="1902038at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35385:SF2">
        <property type="entry name" value="PROTEIN B, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35385">
        <property type="entry name" value="PROTEIN B, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS80246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="190" mass="21451" checksum="E8F34BAD67F5A2C7" modified="2019-05-08" version="1">MPLYTLEDLNKWKDDFEQNSTSTFRKTAPYPNVGQKVLFKGRYHFHHKGGKNQHIPEFPASVSLKWIHNHDICTASALRYRDVGPAAEEKLIGFFNDGLSPSSALDALHKSIEDDPNYVTMMADRQIVPHYFFVNSVGGRALRHSPELAPLRADLAAPLHQPQKSASHNRELAPLCTSLTISENIDYKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TGL5</accession>
    <name>A0A433TGL5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_011536</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000377">
        <property type="protein sequence ID" value="RUS80713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A433TGL5"/>
    <dbReference type="OrthoDB" id="1883493at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016500">
        <property type="term" value="F:protein-hormone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15136">
        <property type="entry name" value="7tmA_Glyco_hormone_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002131">
        <property type="entry name" value="Gphrmn_rcpt_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF82">
        <property type="entry name" value="RICKETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00373">
        <property type="entry name" value="GLYCHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="159"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="497"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="653"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="929"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1086"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1185"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="516"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="668"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="692"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="710"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="929"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="960"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="998"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1149"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1185"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1222"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1336"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS80713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1347" mass="148420" checksum="B1C6B7AD5F8F565C" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TGP9</accession>
    <name>A0A433TGP9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_011557</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000378">
        <property type="protein sequence ID" value="RUS80691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TGP9"/>
    <dbReference type="STRING" id="188477.A0A433TGP9"/>
    <dbReference type="OrthoDB" id="8799554at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="190"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS80691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="336" mass="38163" checksum="CD78E924F557D6A5" modified="2019-05-08" version="1">MSHPKPRKPRPLGSLRHISRNVPEKLPSIPHRLPEISPDAEHLKAGIHGNAMAVPPPQAETTRRSVDERPKSDKSLVGVKPSKSSMSSTSAVSHENCEKEIKEGLVREKDLKDTVSCLTKQIEELKIALRKKEDENKALQTRLQTQEEEAASRLSEEQTAHQHTRDSLKEVQVELEQAHEFNGLMSRQHAEDMEKQKAELEKRLADTTAEKDAQIADRDQKLSRLKSQMADALKGNSWERQQQLEELTKELSRIQEESDLLRMKIKSLSKNKQGQCSNCDDNKVKVTKLQSQVKEKDVTIKELKTLCSKFESQLTTQDKLLEQWASSQGHKITAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TH82</accession>
    <name>A0A433TH82_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_011296</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000364">
        <property type="protein sequence ID" value="RUS80945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TH82"/>
    <dbReference type="OrthoDB" id="6061881at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010695">
        <property type="entry name" value="FAIM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038513">
        <property type="entry name" value="FAIM1_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06905">
        <property type="entry name" value="FAIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS80945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="128" mass="14301" checksum="EF291FE47FACC9A8" modified="2019-05-08" version="1">MSVILLAGRKKAIGKKRKVVKKVGVGCEGKEPTMTASWRLTTSGKKACISFSRDNMNVYVDGEPIECVAYITDNGYDLDLIFNLGTKKGHIYSDVEGTEMTNYLFFDEQLVAQDKQTNLKSGHRPDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TKK9</accession>
    <name>A0A433TKK9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_010113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000301">
        <property type="protein sequence ID" value="RUS82139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TKK9"/>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS82139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="25854" checksum="BC8EB47A6D5E46F1" modified="2019-05-08" version="1" fragment="single">YYDYKTEDIRHYPSHRRLDGKDIKKIPTKATTTRGVFWNGVWSLSDMMTQLLLLLLLLCHGGEPQWNPREDHEDFKAQVELSLSHHPGRVYSGAGPDLLVMQVSGVNTITGEQVSNFKFEQSAYADYFNIDSMGYIRTRREINFGLSKEFGLMVVGQNGNKVGYKYIQIIVSEENLFPPEFETDNFRFQIYGRDVGATIGRIPVYDKDEKAYNRDVLLRAKVDPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TKV6</accession>
    <name>A0A433TKV6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA (guanine-9-)-methyltransferase domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_010110</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000301">
        <property type="protein sequence ID" value="RUS82136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TKV6"/>
    <dbReference type="STRING" id="188477.A0A433TKV6"/>
    <dbReference type="OrthoDB" id="278300at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097745">
        <property type="term" value="P:mitochondrial tRNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070131">
        <property type="term" value="P:positive regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18102">
        <property type="entry name" value="Trm10_MRRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028564">
        <property type="entry name" value="MT_TRM10-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038459">
        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025812">
        <property type="entry name" value="Trm10_C_MTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007356">
        <property type="entry name" value="tRNA_m1G_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563">
        <property type="entry name" value="TRNA (GUANINE-9-) METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563:SF5">
        <property type="entry name" value="TRNA METHYLTRANSFERASE 10 HOMOLOG C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51675">
        <property type="entry name" value="SAM_MT_TRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent MTase TRM10-type" evidence="10">
        <location>
            <begin position="250"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS82136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="442" mass="51281" checksum="784127981C07D2FD" modified="2019-05-08" version="1">MALKSFTRLNSSLVRRINQLHSVEQSCCLKPVQTAIPSIGSMQICCQNYASISHCGRTKNSNLRVAQLQPLNLGRSLASSDSFGYRKLVFARHMSGVVFSRYTKDIDLEKLKEDLKRESKETGQQILLVDRVKQIVAGRCAETIANLDEDGKKKLRVLQLEHNFLYSEGHDIPNPDVMTDENWVEAMELSSKSQRLKYYLYVQKKSHLKMAGQLKKAAHKEEMQNRLKSEEYEHGRIFMRIYDQTMRRWLNYGMSRAMQHGMPLVIDMDYVDLMRPQEQKNTAHQLHDVYCINRGDPGQDPFHLHFTGCHPNNAILKLMQVKTQDSPVLFSTVTEQSYVDMFDKDRLVYLSPQGRQVMKAYDPEAVYIIGAFNDKATQKPVSYARAMEQGIKCQRLPIDEHLHWNQGTKNLTLDQMMRIMLDVKSKLPWKTAFRHIPQRKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TV44</accession>
    <name>A0A433TV44_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_006789</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000169">
        <property type="protein sequence ID" value="RUS85456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TV44"/>
    <dbReference type="STRING" id="188477.A0A433TV44"/>
    <dbReference type="OrthoDB" id="6376512at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="55"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS85456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="320" mass="35790" checksum="D7B9E98321FAFE8D" modified="2019-05-08" version="1" fragment="single">MPDTTEATATLGHENWPLSDPGPSVASTFESSIPNWEKALEVGALGLICATAVVSNFSLWLVVLTTKSLRNESNFLILCLSLADLLVSVVSMPITVATIVSGGWTFPHKMCTALGYINMLAFVSSVESLGVISINRYVKICHPSQFIDIYTTRSVLLMFAGVWLISGIMSLPPLFGWAKYSYLPLSSICFCDWPRSPSYAFFMIACCFCVPCGVMTVCYIRILLAFRQSRKTLQARREEIRLTTSLLVVVALFIVCWFPYCISMFMSIYRPDLSGRALDMTSLLLGYMNSCVNPIVYGLMNKRFKEGYRKLFTKCRFRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U3P8</accession>
    <name>A0A433U3P8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_003786</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Antp homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000082">
        <property type="protein sequence ID" value="RUS88449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U3P8"/>
    <dbReference type="STRING" id="188477.A0A433U3P8"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000017">
        <property type="entry name" value="Homeobox protein antennapedia"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050296">
        <property type="entry name" value="Antp_homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017995">
        <property type="entry name" value="Homeobox_antennapedia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001827">
        <property type="entry name" value="Homeobox_Antennapedia_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45659:SF4">
        <property type="entry name" value="HOMEOBOX PROTEIN ABDOMINAL-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45659">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00025">
        <property type="entry name" value="ANTENNAPEDIA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00032">
        <property type="entry name" value="ANTENNAPEDIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="11">
        <location>
            <begin position="434"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="436"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="151"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="495"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS88449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="538" mass="60930" checksum="D02193C3BB8DBB17" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U4M3</accession>
    <name>A0A433U4M3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UV excision repair protein RAD23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_003486</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RAD23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000074">
        <property type="protein sequence ID" value="RUS88769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U4M3"/>
    <dbReference type="STRING" id="188477.A0A433U4M3"/>
    <dbReference type="OrthoDB" id="419317at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14380">
        <property type="entry name" value="UBA2_Rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01805">
        <property type="entry name" value="Ubl_Rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000254">
        <property type="entry name" value="UV excision repair protein Rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.540:FF:000001">
        <property type="entry name" value="UV excision repair protein RAD23 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000002">
        <property type="entry name" value="UV excision repair protein RAD23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000003">
        <property type="entry name" value="UV excision repair protein RAD23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.540">
        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004806">
        <property type="entry name" value="Rad23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015360">
        <property type="entry name" value="XPC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036353">
        <property type="entry name" value="XPC-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00601">
        <property type="entry name" value="rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621:SF0">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09280">
        <property type="entry name" value="XPC-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01839">
        <property type="entry name" value="RAD23PROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101238">
        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="161"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="328"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="80"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="205"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="80"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="115"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS88769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="378" mass="40360" checksum="5E02DDFA5312BA2B" modified="2019-05-08" version="1">MMMITLKTLQQQTFKLEVTPETLVKELKEKIEKEKGKEYPASGQKLIYAGKILDDAKPLDDYKIEEKNFIVVMVTKPKAAPPAASTKAPEAAPTETPQAAAAAAAAAPTLPTPAAPTTITTAPPQASATTTAPTTPTTASSTPQATGDTLQFAESNLVTGQAYENMVQQLMLMGFDRENVVRALRASFNNPERAVEYLIGGIPDAQEEPIGGGGGGGAPPRPADASESNVSMASNPSSESSLSQQGTPEDPLAFLRSQPQFQRMRQAIQENPGLLPALLQQIGQNNPRLLQMISQNQERFVQMLNEPESGSDQEGAGGPNAPGYISVTPEEKQAIDRLKALGFPEAMCIQAYFACDKNEDLAANFLLSQNFDDDDLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U5P7</accession>
    <name>A0A433U5P7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_003118</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="RQTK01000065">
        <property type="protein sequence ID" value="RUS89110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U5P7"/>
    <dbReference type="STRING" id="188477.A0A433U5P7"/>
    <dbReference type="OrthoDB" id="106623at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008655">
        <property type="term" value="P:pyrimidine-containing compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000023">
        <property type="entry name" value="Probable uracil phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="10">
        <location>
            <begin position="66"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS89110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="212" mass="24232" checksum="C79D32FD4F6B3163" modified="2019-05-08" version="1" fragment="single">MEPVKGACLQTMDPDVIPLYKAVNECKIGPESRKENNTHTDGNDYYYTDLFDFGPKFIRMRLTDGVRELQTVIRDKATPRNDFIFYADRLIRLVVEEGLNKLPYRKCDVVTPTGQVYEGLRYEKGNCGVSIVRSGEAMEQGLRDCCRSIRIGKILIQSDDDTHDARVVYANLPKDINQRKVLLMYPIMCTGNTVSKALEILQMNNVKEENII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U8C0</accession>
    <name>A0A433U8C0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_002176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000041">
        <property type="protein sequence ID" value="RUS90063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U8C0"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS90063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="201" mass="21823" checksum="5E4F840B0880A295" modified="2019-05-08" version="1">MDPCTKIYNKDPCPLSPELQLGLNPQPSNCQLHALPYTKSAPAMSPENRSQPHVHGSLYQKPQWGSVCPIAGLTTGFEPATFQLSAVCSTTSSLSPENRSQPHVHGSLNQNLQQGSVSPIAGVTVRFEPDTFQLSAGRSTRSPHRPCHLRTGASHCPRIPVPKNYNKDPYSPSPNVQLGSNQQPSNNQFHALPEVHTVHVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U8D6</accession>
    <name>A0A433U8D6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Biogenesis of lysosome-related organelles complex 1 subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_002126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BLOC1S2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000040">
        <property type="protein sequence ID" value="RUS90084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U8D6"/>
    <dbReference type="STRING" id="188477.A0A433U8D6"/>
    <dbReference type="OrthoDB" id="244061at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099078">
        <property type="term" value="C:BORC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032418">
        <property type="term" value="P:lysosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019269">
        <property type="entry name" value="BLOC1_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46479">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46479:SF1">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10046">
        <property type="entry name" value="BLOC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS90084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="18087" checksum="C46E0BD082635676" modified="2019-05-08" version="1">MAESQDGMESQTSATSSSGSSSMIAKSPEDEFPKVDQGASSPTTHETSHDSGPPQDVVELCRDTFQKTAEYLRGELDGTVEDYKLLEKMNTVTSTRYSEMKHIALSINGALKSLNEKYKSLQPYLEQIDQIEESVSTLEQAAYSLDQYSKRLESKFKALERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UA14</accession>
    <name>A0A433UA14_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein 223</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_001553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000027">
        <property type="protein sequence ID" value="RUS90653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UA14"/>
    <dbReference type="STRING" id="188477.A0A433UA14"/>
    <dbReference type="OrthoDB" id="5950063at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026100">
        <property type="entry name" value="Tmem223"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045325">
        <property type="entry name" value="TMEM70/TMEM186/TMEM223"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14549">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14549:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06979">
        <property type="entry name" value="TMEM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS90653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="29794" checksum="8D024F07308197E3" modified="2019-05-08" version="1">MLRQSTICLSLFAKAIKCETANAAASLGKHNGGISSKLRLNLICRTQTPFSHHRLFSNLTIKSICSQKTLITSWRSMQSKPFNISGTVKSDTLLFAHKNDAFYKMFAYFGIFQMGMWAYLSLFAFQQLKAVPVGLQDTSEMPWYKRLLYKQGHYKNALSLLSFIVGGVVLFITVAYPRRVIKSLYLLKGGDHVKITTYSWLGQTRTFTKPVDHLSCMEARTGKGPHIPVKIRDTNFYYIIDKQGSFPKTDLFDFVVGVKRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UA99</accession>
    <name>A0A433UA99_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_001544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000026">
        <property type="protein sequence ID" value="RUS90740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UA99"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS90740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="103" mass="11055" checksum="06523AB388EF6065" modified="2019-05-08" version="1" fragment="single">AVSTQGTSPGRPPETPETQDGETPETQNGETPDRLDGETPDRLNGETPETQDGKTPETQDGETPETQDGETPETQNGETPETQNGETPDHLDGEIPNRRDGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UEA4</accession>
    <name>A0A433UEA4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_000143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000002">
        <property type="protein sequence ID" value="RUS92119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UEA4"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS92119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="161" mass="18262" checksum="AB33ECC135F31A83" modified="2019-05-08" version="1" fragment="single">CQITACQLQALQTGREFGPGADLYNRLASDLPRLIHRVNKMSLWQEASALLHRLFNTFGNYHILQIAVAAAAIVTSSKAGVYVYTRQRRRQLMLKIQARRQKTKQGIEELREELKNIQINPDIPTWGISQLHTALQSGHVTATEVLRAYQAKALEVNERTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z9S1</accession>
    <name>A0A3S0Z9S1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BACK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_019480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001022">
        <property type="protein sequence ID" value="RUS72762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z9S1"/>
    <dbReference type="STRING" id="188477.A0A3S0Z9S1"/>
    <dbReference type="OrthoDB" id="6086527at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.820">
        <property type="entry name" value="PHR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012983">
        <property type="entry name" value="PHR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038648">
        <property type="entry name" value="PHR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08005">
        <property type="entry name" value="PHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BACK" evidence="3">
        <location>
            <begin position="79"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS72762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="377" mass="41863" checksum="E591F70D4ED2161F" modified="2019-04-10" version="1">MFLGPMRATSQDDSGSSVVIPDIEPQPFLAFLRYLYCGEAAITPENVIYLLYAAQKYAVLGLASKCISFVDQVLDTDNACTVLEQAHIFNEKDFHCTVLALILRKAEEVLAADDVTYLCDDCLATIVGSSKLMACEDLILNACLRWAESECKRRSLDVSDSNFRLVLNKILYKIRFPLLPVEVFMEKVVPGSLLTEEEKVDVMGRYIVANRPSSFFNTELRIAQRQLRLNRFQNLFGAGFNNKSGSNAIAFKVSQDIVLEGFTIYGSCRPSELELEIKGQVLDQKDAIISSINKTIYTQGDKGLYDVIFDESAPLEKNVLYTLVVSIAGAHTFAGKDGRLTTFSHNVAFTFSHSEKSQTGTTVSHGQLPGLIFALKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZCV1</accession>
    <name>A0A3S0ZCV1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_016263</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000695">
        <property type="protein sequence ID" value="RUS75981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZCV1"/>
    <dbReference type="STRING" id="188477.A0A3S0ZCV1"/>
    <dbReference type="OrthoDB" id="8065060at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.770:FF:000001">
        <property type="entry name" value="Acid-sensing ion channel subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF300">
        <property type="entry name" value="PICKPOCKET PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 12" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS75981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="250" mass="28577" checksum="C627129A92EB516C" modified="2019-04-10" version="1">MISLQADSLMAELGHIKSGTLGAIAQALSLARRFLFQGTLSKRQVAAEFLRDDIVKTQGTLKNFFNEVRTRGHAVYDDWIQVEEAAIAIWTMAIEEENLQTYYAAMNMTHMQATPESKARDIREWCRQSRDQHDLRRVVNNVDAQFTGALSDMLDEMTSFKETEKIDARFMRENILHLNVFYKELSYEQITQQEAYDLFALLCDIGGSMGLFVGASVITVFEVMDLVVFTYLARLLLPKPKEDRATQVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZFL0</accession>
    <name>A0A3S0ZFL0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_018458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000901">
        <property type="protein sequence ID" value="RUS73778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZFL0"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS73778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="131" mass="15168" checksum="623124739707589B" modified="2019-04-10" version="1">MDQIHDKEVELHDRDSVVLHKTARAKFECKKGWSAYLKCTMLSPHRISVYAKIQTTALSELGKNAFMEVKTGPLSENVDLRAVVYMKMDTKQPSFELWRQLQRNPDRGEEIVALLRIWDGNSRLMEGCNIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZHD5</accession>
    <name>A0A3S0ZHD5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sushi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_017310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000785">
        <property type="protein sequence ID" value="RUS74930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZHD5"/>
    <dbReference type="STRING" id="188477.A0A3S0ZHD5"/>
    <dbReference type="OrthoDB" id="6158054at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050350">
        <property type="entry name" value="Compl-Cell_Adhes-Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19325">
        <property type="entry name" value="COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19325:SF560">
        <property type="entry name" value="SUSHI, VON WILLEBRAND FACTOR TYPE A, EGF AND PENTRAXIN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="19"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="252"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS74930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="542" mass="58748" checksum="1D03A5212A31DF8D" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZHV5</accession>
    <name>A0A3S0ZHV5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_017001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000760">
        <property type="protein sequence ID" value="RUS75236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZHV5"/>
    <dbReference type="STRING" id="188477.A0A3S0ZHV5"/>
    <dbReference type="OrthoDB" id="440781at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042593">
        <property type="term" value="P:glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16105">
        <property type="entry name" value="Ubl_ASPSCR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17075">
        <property type="entry name" value="UBX1_UBXN9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16118">
        <property type="entry name" value="UBX2_UBXN9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021569">
        <property type="entry name" value="TUG-UBL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059238">
        <property type="entry name" value="UBX1_UBXN9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467:SF1">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11470">
        <property type="entry name" value="TUG-UBL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="450"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS75236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="562" mass="63506" checksum="656EA46CC791CAD7" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZIK9</accession>
    <name>A0A3S0ZIK9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Centromere protein J C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_013600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000498">
        <property type="protein sequence ID" value="RUS78630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S0ZIK9"/>
    <dbReference type="OrthoDB" id="10252174at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061511">
        <property type="term" value="P:centriole elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.450.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009852">
        <property type="entry name" value="CENPJ_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047002">
        <property type="entry name" value="Tcp10_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026581">
        <property type="entry name" value="TCP10L/CENPJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058029">
        <property type="entry name" value="Tubulin-bd_CENPJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10331:SF6">
        <property type="entry name" value="SPINDLE ASSEMBLY ABNORMAL 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10331">
        <property type="entry name" value="T COMPLEX PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07202">
        <property type="entry name" value="Tcp10_C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25779">
        <property type="entry name" value="Tubulin-bind_CPAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENPJ tubulin-binding region" evidence="5">
        <location>
            <begin position="446"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Centromere protein J C-terminal" evidence="4">
        <location>
            <begin position="1412"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="domain" description="Centromere protein J C-terminal" evidence="4">
        <location>
            <begin position="1486"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="domain" description="Centromere protein J C-terminal" evidence="4">
        <location>
            <begin position="1522"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="domain" description="Centromere protein J C-terminal" evidence="4">
        <location>
            <begin position="1560"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="125"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="329"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="618"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="760"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="841"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1187"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1226"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1331"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1035"/>
            <end position="1180"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="409"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="649"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="699"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="760"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="841"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="891"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="910"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="946"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1187"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1234"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1261"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1293"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS78630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1605" mass="175876" checksum="0FEF0D402A1DE75D" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZLG6</accession>
    <name>A0A3S0ZLG6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_014623</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000566">
        <property type="protein sequence ID" value="RUS77623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZLG6"/>
    <dbReference type="OrthoDB" id="19923at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001136">
        <property type="term" value="P:negative regulation of endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808:SF2">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="92"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="271"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS77623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="459" mass="52854" checksum="3CD9A11E2248C25D" modified="2019-04-10" version="1">MAAKNEYSNFLGSDEPELEFDEDGTELSASKEGPSEFSSPYSHIPSLPWDVELAKEADCGAFRGGAITPDGLIDEDFEKELGTPAEEDGPNEFSDVERFGVIEVAGDDLYGRKVIVFSACKLPCNQTFDHQRLLLYIKHTLDKYVEQDYVLVYFHHGLHRGNKPKLSWLRQAYREFDRKYKKNLKMLYLVHPTNFIKVLWQIFRPFISVKFGQKMMYVNYLVELKRHLPFDQLAIPLPVLEFDAQKVEKNKVPYPYDSSPPKEKKAQQFGLTLQSIKENTGLIIPLPVEDTIEFLKATGGDECDGLFRRCARVSTMKEVQEKYDDGEKVNFYTYGDPHLAAAILKKFLRELKEPLMTFDLFEPITRLHFLEPSKQLTEVQRILQDELPEDNYTILKFVFQFLQRVVSKSDLNQMTAENVATVFGPNIAWPTGQANLTNVEQAVKFALILINNFDDVFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZNT7</accession>
    <name>A0A3S0ZNT7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Uridine kinase</fullName>
            <ecNumber evidence="17">2.7.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">EGW08_012984</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">EC2010</strain>
            <tissue evidence="21">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">May contribute to UTP accumulation needed for blast transformation and proliferation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 17">
            <text>cytidine + ATP = CMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 17">
            <text>uridine + ATP = UMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16825"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="17">Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with RNF19B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the uridine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.48" evidence="17"/>
    <dbReference type="EMBL" id="RQTK01000462">
        <property type="protein sequence ID" value="RUS79254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZNT7"/>
    <dbReference type="STRING" id="188477.A0A3S0ZNT7"/>
    <dbReference type="OrthoDB" id="10257085at2759"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00637"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00579">
        <property type="reaction ID" value="UER00640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043771">
        <property type="term" value="F:cytidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004849">
        <property type="term" value="F:uridine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044211">
        <property type="term" value="P:CTP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02023">
        <property type="entry name" value="UMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000010">
        <property type="entry name" value="Uridine-cytidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000200">
        <property type="entry name" value="Uridine-cytidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000764">
        <property type="entry name" value="Uridine_kinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004018">
        <property type="entry name" value="PRK05480.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00235">
        <property type="entry name" value="udk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00988">
        <property type="entry name" value="URIDINKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="19">
        <location>
            <begin position="109"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="20">
        <location>
            <begin position="339"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00065923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RUS79254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="546" mass="61072" checksum="AD2EE4BA26BA7EDD" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZQ11</accession>
    <name>A0A3S0ZQ11_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_012131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000410">
        <property type="protein sequence ID" value="RUS80132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS80132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="101" mass="10962" checksum="05D3683E8C696A40" modified="2019-04-10" version="1" fragment="single">MACAFPTRSRTNGKKNGAACTEENXLLNTTSVKMTEAPFGGNRSDSDEDDIVEDYEDGISCKTPCFRGRTSLERLLLIVLFVCLVIIIGLAVGLTRPLIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZTZ6</accession>
    <name>A0A3S0ZTZ6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein-serine O-palmitoleoyltransferase porcupine</fullName>
            <ecNumber evidence="9">2.3.1.250</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_006430</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[Wnt protein]-L-serine + (9Z)-hexadecenoyl-CoA = [Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + CoA</text>
            <dbReference type="Rhea" id="RHEA:45336"/>
            <dbReference type="Rhea" id="RHEA-COMP:11170"/>
            <dbReference type="Rhea" id="RHEA-COMP:11171"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:61540"/>
            <dbReference type="ChEBI" id="CHEBI:85189"/>
            <dbReference type="EC" id="2.3.1.250"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the membrane-bound acyltransferase family. Porcupine subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.250" evidence="9"/>
    <dbReference type="EMBL" id="RQTK01000159">
        <property type="protein sequence ID" value="RUS85801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZTZ6"/>
    <dbReference type="STRING" id="188477.A0A3S0ZTZ6"/>
    <dbReference type="OrthoDB" id="5968863at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990698">
        <property type="term" value="F:palmitoleoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061355">
        <property type="term" value="P:Wnt protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF12">
        <property type="entry name" value="PROTEIN-SERINE O-PALMITOLEOYLTRANSFERASE PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS85801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="501" mass="57096" checksum="BC4C66C4008D0D2D" modified="2019-04-10" version="1">MGDYDYEYDDMEMDDYDPDAISYEQLMDYVDNYEGELTPEMLEVIETYKKRAGHNAGMDVSRIPVHELIENCVSPSCVQVLQLLLPLFIMCAAFRFFCYLSKAGSKDARVPAWLVHLTSALLGIMVLHSFFDMALLYLVACCTLAYFTFCLVCSWQRKYCGLAGAGVVVLVSLFCELWIVEPTTWHKIRGGQIILSMKIISLGIDVSQGDIADLPNVFEFLGYCFNVGSVIFGPWISYSQYYQLVENDNNMNGFMWCGQVLITSSLGIFCLVFSNCLTHWLILDNSQKWILAYRDAQSFRFSHYFVSFISDATSSLSGLTLRDNAIMNVVRPQNIEIPRSLVEVVTNWNLPMHNWLKTYVFKTVRPYGVFLAVLMTYAASSLLHGLNFQLAAVLLSLGFYSYTEFVFRRRLSVIYDACIQAKRCKPKCDHKYTSSHPVVMLVNVCLGALAVFHLAYLGLMFDSSAGEEKGYTMWHTLDKWSGLDFLSHWVALGTFILYWIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZUA5</accession>
    <name>A0A3S0ZUA5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_006235</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000153">
        <property type="protein sequence ID" value="RUS86023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZUA5"/>
    <dbReference type="STRING" id="188477.A0A3S0ZUA5"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF93">
        <property type="entry name" value="NUAK FAMILY SNF1-LIKE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS86023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="217" mass="24427" checksum="5C8CBC5C9047E1E6" modified="2019-04-10" version="1" fragment="single">LSVHPVFEKKDKIVLVMDYAQGGELYDYLNKMGRLGEWEARRIFRQIVSAIHCCHQVRFSSISALSLNCPCVCNPHRLPLLYSQIADFGLANYYSESSQLSTFCGSPLYASPEIVNGRPYYGPEVDVWSLGVILYTLVYGSMPFESNSLVSLKQQISDGDYRQPSRPSDAAGLIRHMLTVTPARRATMDDALKHWWINFGHAHMPNGQAYNPCGDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZVC2</accession>
    <name>A0A3S0ZVC2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_004625</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000105">
        <property type="protein sequence ID" value="RUS87640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZVC2"/>
    <dbReference type="STRING" id="188477.A0A3S0ZVC2"/>
    <dbReference type="OrthoDB" id="407010at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003834">
        <property type="term" value="F:beta-carotene 15,15'-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
        <property type="term" value="P:carotene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042574">
        <property type="term" value="P:retinal metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF24">
        <property type="entry name" value="CAROTENOID ISOMEROOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="522"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS87640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="542" mass="60898" checksum="7DF4FE93696A1875" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZVH1</accession>
    <name>A0A3S0ZVH1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_004482</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000102">
        <property type="protein sequence ID" value="RUS87736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZVH1"/>
    <dbReference type="STRING" id="188477.A0A3S0ZVH1"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17331">
        <property type="entry name" value="MFS_SLC22A18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24002">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24002:SF3">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="66"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS87736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="445" mass="48336" checksum="58D569ED05DCC9C0" modified="2019-04-10" version="1" fragment="single">MAEMNSQRDNLSSNGAELSLRKTGTMSSSSVIDTGTEELESKENSTEDKMDGNNFVTLFGRRFNRFVMVTHINIFLYSCGFWVQQSVFPYLSKQLGADPVTFGYLQTTFAVVQLAGGPLFGRFGDLFGSRQAMMLAFASASVSYFLLSVSSSIPLLFVSRLPSIFMHAMQAGQMIVTDVCSPDKRADALGKLGISYGVGMVVGPMVGGTVSRLFSIEKGALVACVLSLISIVITYVYVPSSVKKSSSQDSNIFSPSKILRLLQAPGAFFLLTIKMGTGLFFLMLKSMFSVVALERFQLPPQQNSFVMSYVGVMAMMVQGVGIGYVTKSFDENRILAGSAMSLMLGYLMITFATSIWHMCVVFIPLIVGLTFQNVVTTSALTHTVSPTDTGAMLGLSMAVNSLIRSVSPTIGGYMLTRFGFESFGYLGFIASSTVTVVLLYKRRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZVU7</accession>
    <name>A0A3S0ZVU7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Delta(24)-sterol reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_007978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000212">
        <property type="protein sequence ID" value="RUS84226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZVU7"/>
    <dbReference type="STRING" id="188477.A0A3S0ZVU7"/>
    <dbReference type="OrthoDB" id="6083373at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040165">
        <property type="entry name" value="Diminuto-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801">
        <property type="entry name" value="24-DEHYDROCHOLESTEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801:SF0">
        <property type="entry name" value="DELTA(24)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS84226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="36631" checksum="4333E5F1A64BF9FC" modified="2019-04-10" version="1" fragment="single">DENPDLFYAIPWSHGTLGFLVAAELSIVPASKYVRMEYQPVVGHGELGRLLNDPEIYRDYQFVEALVYSQTQAVLMLGNMVDTAEPGKVNAIGDYHKPWFFKHVEGFLRHGAGVEYIPLRHYYHRHTRSIFWMLEDIIPFGNNVVFRWLFGWMVPPKISLLKLTQGETIKQMYEKYQVIQDMLVPMKDLTRSLEFFHQELDLYPLWICPFMLYSQKGLVHPRGDKDEMYVDIGAYGTPKVRNFSTIPSTRRLEDFVCKVNGFQMLYADSYLSQDQFRKMFDHSLHDKMRRELDCEKAFPEIYDKVNRKART</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZX16</accession>
    <name>A0A3S0ZX16_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_004091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000092">
        <property type="protein sequence ID" value="RUS88129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZX16"/>
    <dbReference type="STRING" id="188477.A0A3S0ZX16"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS88129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="105" mass="11471" checksum="59FE7810FB68E0CA" modified="2019-04-10" version="1" fragment="single">MRACEVCKCLSKLRTEVCKCLSKLGTEVCKSLSKLRTEVCKCLSKLGTEVCKCLSKLGTEVCKCLSKLGTEVCKCLSKLGTEVCKCLSKLGTEVCKCLSKLRSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZZA2</accession>
    <name>A0A3S0ZZA2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_001846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000034">
        <property type="protein sequence ID" value="RUS90351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZZA2"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS90351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="104" mass="11529" checksum="F40E74744C33E86B" modified="2019-04-10" version="1">MKHNSTVGHMKHNSTVGHMKHNSTVGHMKHNSTVGHMKHNSTVGHMKHNSTVGHMKHNSTVGHMKHNSTVGHMKHNSTVGHMKHNSTVGHMKHNSTVGHMKHNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A0S6</accession>
    <name>A0A3S1A0S6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_001340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000022">
        <property type="protein sequence ID" value="RUS90943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A0S6"/>
    <dbReference type="OrthoDB" id="6188974at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001299">
        <property type="entry name" value="Ependymin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10697">
        <property type="entry name" value="MAMMALIAN EPENDYMIN-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10697:SF1">
        <property type="entry name" value="MAMMALIAN EPENDYMIN-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018682357" evidence="1">
        <location>
            <begin position="17"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS90943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="211" mass="22830" checksum="A69A1C1DCFDC3378" modified="2019-04-10" version="1">MLTLAAFTLLLAGACALSANTVTTMMQDLKVSSKLPPPCCSPPTWQAELVDLKSPYQVDSLIAVDYSKNMEGVITTSRATGQVIGRSLIDYSKHLIYEAVYVPDMAPTCKKVPFNMPLARCMNDTTITDLVYLGSSTLGMKGAGLNYDGYSFKAADNEISIALVPIPNSGNLCYPVIESLKNKQQDSIYIFLQAESKVNDPTIFDVPAPCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A0W9</accession>
    <name>A0A3S1A0W9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein misato homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_000685</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the misato family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000009">
        <property type="protein sequence ID" value="RUS91570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A0W9"/>
    <dbReference type="STRING" id="188477.A0A3S1A0W9"/>
    <dbReference type="OrthoDB" id="271881at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06060">
        <property type="entry name" value="misato"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049942">
        <property type="entry name" value="DML1/Misato"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029209">
        <property type="entry name" value="DML1/Misato_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019605">
        <property type="entry name" value="Misato_II_tubulin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION REGULATOR MISATO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391:SF0">
        <property type="entry name" value="PROTEIN MISATO HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10644">
        <property type="entry name" value="Misat_Tub_SegII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14881">
        <property type="entry name" value="Tubulin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Misato Segment II tubulin-like" evidence="5">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="DML1/Misato tubulin" evidence="6">
        <location>
            <begin position="168"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="117"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS91570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="576" mass="64280" checksum="9D563B9A815F4E15" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AAK5</accession>
    <name>A0A3S1AAK5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_005374</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000126">
        <property type="protein sequence ID" value="RUS86837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AAK5"/>
    <dbReference type="STRING" id="188477.A0A3S1AAK5"/>
    <dbReference type="OrthoDB" id="408493at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005049">
        <property type="entry name" value="STL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31362:SF0">
        <property type="entry name" value="EXOSTOSIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31362">
        <property type="entry name" value="GLYCOSYLTRANSFERASE STELLO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03385">
        <property type="entry name" value="STELLO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS86837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="674" mass="77189" checksum="89972A56B346B75A" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AET8</accession>
    <name>A0A3S1AET8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Protoporphyrinogen oxidase</fullName>
            <ecNumber evidence="4 11">1.3.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_002261</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>protoporphyrinogen IX + 3 O2 = protoporphyrin IX + 3 H2O2</text>
            <dbReference type="Rhea" id="RHEA:25576"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
            <dbReference type="EC" id="1.3.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.4" evidence="4 11"/>
    <dbReference type="EMBL" id="RQTK01000043">
        <property type="protein sequence ID" value="RUS89994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AET8"/>
    <dbReference type="STRING" id="188477.A0A3S1AET8"/>
    <dbReference type="OrthoDB" id="419752at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004729">
        <property type="term" value="F:oxygen-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004572">
        <property type="entry name" value="Protoporphyrinogen_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00562">
        <property type="entry name" value="proto_IX_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF3">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 11" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 11" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="12">
        <location>
            <begin position="12"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS89994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="481" mass="52565" checksum="2898694712A75B22" modified="2019-04-10" version="1">MSTAVVIGAGASGLASAFYIQKYLPKFSKVIVLEGSKQVGGWVSSTKHSDGCIFEHGPRSLRPVGEQGRNTLHLVEELGLSHDVLPVFRSDASAKNRYLYVKKKLCPLPNSLAGLFKTLPPFSKSLIRTLAMEPFHRRGKTDESVHSFVRRRLGREMADIAIDAMVRGIFAGDCRKLSVQACFPPLYKMERDYGSLFAGALFGSKGPKDDAESSHLTRRAKNEAWASWSLANGMQSLTDSLAESVGGSKGGEVRLESPCVRLSPASDGSGKMTVQTESDTINADLVVSAIYSKDLASVLPESMEDLREDLSALPSVNVVVVNLEYKDNVLPVKGFGHLLPSSENKQILGIVYDSCTFPEHNRKNCPDSTRLTVMMGGAWYNHLLTREGVLPDGNELVWMATDAAAKQLGIKSHPIRWQVTLQKECIPQYQLGHVAWVQGLEEKIQQSKLPLHLVGASYRGPAVNDCINNARKMVASLAQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1ASD3</accession>
    <name>A0A3S1ASD3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Complex I-B12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">NADH-ubiquinone oxidoreductase B12 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EGW08_021486</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">EC2010</strain>
            <tissue evidence="16">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB3 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001340">
        <property type="protein sequence ID" value="RUS70754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1ASD3"/>
    <dbReference type="STRING" id="188477.A0A3S1ASD3"/>
    <dbReference type="OrthoDB" id="521512at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012576">
        <property type="entry name" value="NDUFB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B12 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08122">
        <property type="entry name" value="NDUF_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RUS70754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="98" mass="10846" checksum="A7EFDBED435D7F9E" modified="2019-04-10" version="1">MGGGPGPPHGVPDWKTYKAEGVPELDRLQKRLAAVGLRDPWIRNEAWRFTEANGGTTTMARTAFRMTFRGFGYAVVAVALTIAYDKIVNRNKPSHGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AVG0</accession>
    <name>A0A3S1AVG0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_018982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000958">
        <property type="protein sequence ID" value="RUS73263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6143625at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="840"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="996"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1023"/>
            <end position="1032"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS73263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1107" mass="124426" checksum="D1B6C3033340A283" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AXB1</accession>
    <name>A0A3S1AXB1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EGW08_017598</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">EC2010</strain>
            <tissue evidence="17">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="RQTK01000812">
        <property type="protein sequence ID" value="RUS74644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AXB1"/>
    <dbReference type="STRING" id="188477.A0A3S1AXB1"/>
    <dbReference type="OrthoDB" id="66726at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051652">
        <property type="entry name" value="MDM2_MDM4_MUL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022170">
        <property type="entry name" value="MUL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12183:SF32">
        <property type="entry name" value="MITOCHONDRIAL E3 UBIQUITIN PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12183">
        <property type="entry name" value="MITOCHONDRIAL UBIQUITIN LIGASE ACTIVATOR OF NFKB 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12483">
        <property type="entry name" value="GIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="312"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RUS74644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="362" mass="40898" checksum="8D04202F62B95FAF" modified="2019-04-10" version="1">MNLDLLDKVLGVSGGISWVVSYVFYRLYRSRTDTARQVKNIPIWEPGEDLLSHLTNDGNLAYAAVEGVVKELNRTLHSRHGNNEGVIMETQLIEHKSQRINGFWSDVKKVLRDTTEYVPFALKPVKDSGTDGNKHVVEVLDPGQAARLRDELETTHDSFEPHRSSLVQIGIDRLFGEVSKGLQESEKMLLTGTSLLGVGKVFLERGQIKMAPPDDLSRTYILTKMRLSELVRHYEAQSSMYKVIALLSALIGGGILSIIVWRQTRAWLERRKQRIQFEDIRRAMAEAAERRRVHISVARNRNSEEAEIDNTCVVCLTNQRQVVALNCGHISLCADCAEALHFPKKCPVCRAAVVRFMPIFHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B311</accession>
    <name>A0A3S1B311_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dr1-associated corepressor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Dr1-associated protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Negative cofactor 2-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EGW08_018427</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">EC2010</strain>
            <tissue evidence="15">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Heterodimer with DR1. Binds BTAF1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NC2 alpha/DRAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000897">
        <property type="protein sequence ID" value="RUS73810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B311"/>
    <dbReference type="STRING" id="188477.A0A3S1B311"/>
    <dbReference type="OrthoDB" id="653904at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001046">
        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22906">
        <property type="entry name" value="HFD_DRAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000032">
        <property type="entry name" value="dr1-associated corepressor isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF5">
        <property type="entry name" value="DR1-ASSOCIATED COREPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="14">
        <location>
            <begin position="17"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="98"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="292"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="380"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00078501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RUS73810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="411" mass="44965" checksum="5D88D2047D7700AD" modified="2019-04-10" version="1">MPKTPSRMSKKKKYNSRFPPARIKKIMQTDEDVGKVAATVPIIISRALELFIESLITETSKATIAKNAKTLSTSHIKQTIHSNKQFDFLRDLVANIPDHNTAEDNNGNANGNGTSDAPQDNGDIPQKKKRGRPRKIKEAPVPNRKKQGGSSKVSPETSEEEDEEEEEDEDEDTESDDGGKTPKPPVTLTNHFSKSLPSSSTSSISYVATHQNSGGVVDINGPQNYPTHILFFTPCISFPPGYTVPALASLTNQQQQLQLPQQMMAHQQSLQQQQHNMGSNIPSSVAPSLSHPYLPSAAFPNHQPPPNFTNNALPSGSLEGYPIPPQFHHSHSPYHHPMPTPMMPPAHHQSAPMQLPQGGPGYPSMAHMPAATTVHVPASVSHSQQAQPINLSMSSQRRPHTRDDEADDYDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B9L5</accession>
    <name>A0A3S1B9L5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">EGW08_016864</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">EC2010</strain>
            <tissue evidence="27">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Secreted enzyme that regulates the endogenous N-fatty acyl amino acid (NAAs) tissue and circulating levels by functioning as a bidirectional NAA synthase/hydrolase. It condenses free fatty acids and free amino acids to generate NAAs and bidirectionally catalyzes the reverse hydrolysis reaction. Some of these NAAs stimulate oxidative metabolism via mitochondrial uncoupling, increasing energy expenditure in a UPC1-independent manner. Thereby, this secreted protein may indirectly regulate whole body energy expenditure. PM20D1 circulates in tight association with both low- and high-density (LDL and HDL,respectively) lipoprotein particles.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine + H2O</text>
            <dbReference type="Rhea" id="RHEA:51312"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:134022"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:51313"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:51314"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O</text>
            <dbReference type="Rhea" id="RHEA:51316"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:133992"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:51318"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-phenylalanine + (9Z)-octadecenoate = N-(9Z-octadecenoyl)-L-phenylalanine + H2O</text>
            <dbReference type="Rhea" id="RHEA:51300"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:134020"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:51301"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="23">
            <dbReference type="Rhea" id="RHEA:51302"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-L-phenylalanine + H2O = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + L-phenylalanine</text>
            <dbReference type="Rhea" id="RHEA:64132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:77016"/>
            <dbReference type="ChEBI" id="CHEBI:149701"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:64133"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine</text>
            <dbReference type="Rhea" id="RHEA:64108"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:59002"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:64109"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:64110"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:64116"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:149697"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:64117"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="24">
            <dbReference type="Rhea" id="RHEA:64118"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N-(9Z-octadecenoyl)-L-asparagine + H2O = L-asparagine + (9Z)-octadecenoate</text>
            <dbReference type="Rhea" id="RHEA:64136"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:149730"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:64137"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>N-(9Z-octadecenoyl)-L-glutamine + H2O = L-glutamine + (9Z)-octadecenoate</text>
            <dbReference type="Rhea" id="RHEA:51356"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:134033"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:51357"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>N-(9Z-octadecenoyl)-L-leucine + H2O = L-leucine + (9Z)-octadecenoate</text>
            <dbReference type="Rhea" id="RHEA:51360"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:134035"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:51361"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="21">
            <dbReference type="Rhea" id="RHEA:51362"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>N-(9Z-octadecenoyl)-L-lysine + H2O = L-lysine + (9Z)-octadecenoate</text>
            <dbReference type="Rhea" id="RHEA:64192"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:149731"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:64193"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N-(9Z-octadecenoyl)-L-methionine + H2O = (9Z)-octadecenoate + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:64144"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:149732"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:64145"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>N-(9Z-octadecenoyl)-L-serine + H2O = L-serine + (9Z)-octadecenoate</text>
            <dbReference type="Rhea" id="RHEA:51352"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:134031"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:51353"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>N-(9Z-octadecenoyl)-L-tryptophan + H2O = L-tryptophan + (9Z)-octadecenoate</text>
            <dbReference type="Rhea" id="RHEA:64176"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:149733"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:64177"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-(9Z-octadecenoyl)-L-tyrosine + H2O = L-tyrosine + (9Z)-octadecenoate</text>
            <dbReference type="Rhea" id="RHEA:64184"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:149734"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:64185"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N-hexadecanoyl-L-phenylalanine + H2O = hexadecanoate + L-phenylalanine</text>
            <dbReference type="Rhea" id="RHEA:64124"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:149699"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:64125"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-octadecanoyl-L-phenylalanine + H2O = octadecanoate + L-phenylalanine</text>
            <dbReference type="Rhea" id="RHEA:64128"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:149700"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:64129"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>an N-acyl-L-amino acid + H2O = an L-alpha-amino acid + a carboxylate</text>
            <dbReference type="Rhea" id="RHEA:15565"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="EC" id="3.5.1.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:15566"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:15567"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>an N-acyl-aromatic L-alpha-amino acid + H2O = an aromatic L-alpha-amino acid + a carboxylate</text>
            <dbReference type="Rhea" id="RHEA:54184"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:84824"/>
            <dbReference type="ChEBI" id="CHEBI:138093"/>
            <dbReference type="EC" id="3.5.1.114"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:54185"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="22">
            <dbReference type="Rhea" id="RHEA:54186"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000747">
        <property type="protein sequence ID" value="RUS75374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B9L5"/>
    <dbReference type="STRING" id="188477.A0A3S1B9L5"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004046">
        <property type="term" value="F:aminoacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043605">
        <property type="term" value="P:amide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.900:FF:000003">
        <property type="entry name" value="N-fatty-acyl-amino acid synthase/hydrolase PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047177">
        <property type="entry name" value="Pept_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE/HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962:SF1">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE_HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="26">
        <location>
            <begin position="71"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00049457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="RUS75374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="334" mass="36967" checksum="40548C804B86BB06" modified="2019-04-10" version="1">MLSSNIQPKRSLYISFGHDEETRGNDGAAQVAERLKEKGVTEFEFVVDEGMTVLEDIVDGVAGPVASVGVSEKGIVVLKLSVELAPGHSSMPPRETAIGILAKAVSRLEENPHPSMLGSGVETDMFESLVPKMGYLQRVIISNMWLFRYPLSWLLSRKPATNAVIRTVTAVTFFNSGIKFNIIPPVAEALVNHRIHPSQTVQEVLDYDRAVIADPRVKMELVYSMEPHPVSGYGQSDFGYQVMKTSVNQIWPNATVVPAIMVGNTDTVHFLNFSGDVYRFSPTHMFPGDPERFHGINERMSVRNYGQVVNFFYHVIRNADQAGLSPAHSPHSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BAN9</accession>
    <name>A0A3S1BAN9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_013207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000475">
        <property type="protein sequence ID" value="RUS79050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BAN9"/>
    <dbReference type="STRING" id="188477.A0A3S1BAN9"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS79050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="334" mass="35008" checksum="DE1E5928F8E32604" modified="2019-04-10" version="1">MTTLSTRCSHSMRTKSGSVWLFGPGEMSQVVGRYWETVGALFPQCPEFMGNSWEIRATGTITEEVSVVCGCHDMVSRFCLDLIEDGCGTHLELIEGGCGTHLELIEGGSGTHLELIEDGCGTHLELIEDGCGTHLELIEGGCGTHLELIEGGSGTHLELIEGGSGTHLELIEGGCGTHLELIEGGCGTHLELIEGGCGTHIELIEDGCGTHLELIEGGCGTHIELIEDGCGTHLELIEGGSGTHLKLIEGGSGTHLKLIEDGSGTHLKLIEDGSGTHLEIIEDGSGTYLELIEGGCGTHLELIEGGSGTHLELIEDGSGTHLELIEEVVLTLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BB01</accession>
    <name>A0A3S1BB01_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_008126</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000218">
        <property type="protein sequence ID" value="RUS84087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BB01"/>
    <dbReference type="STRING" id="188477.A0A3S1BB01"/>
    <dbReference type="OrthoDB" id="6410525at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001517">
        <property type="term" value="F:N-acetylglucosamine 6-O-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051135">
        <property type="entry name" value="Gal/GlcNAc/GalNAc_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704:SF44">
        <property type="entry name" value="LD35051P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018760955" description="Sulfotransferase domain-containing protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="80"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS84087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="401" mass="45492" checksum="3EB2716B82F0AFA0" modified="2019-04-10" version="1">MGRASRRGLAVLCSASALILLYWAGSGGRAVWEPAQFRVVRHKDLDPVTPDNNVAMRSTEGGQTPGQQPDQSQGGTARARVLLVSYMRSGSTFTGDIFQASPQVFYLYEPLIYVNDDDYMAPTERSAKNRLIPIAFGIPHPPEIHNYTLDTLNCGFTDHNLRFLYALTYSQSTTEFDQCQKKLGVKPSNFGECGERLRERCVQSKAVVSKILRLKMWEVERLLREDPELRVIHLVRDPRGVYISRRAARYYFGDAPFCARFNADAAKSAELQAKYPGRILTTRYEDLATNPLGIAKLLFNFGGIPWTEEVQTTLVSMTSNADVQTTEHVFSTKRKNSSLTATSWRQKIAFENSWKLQKLCSSAMELYGYVPFQTDQELRDLNIASFTRDYSHVFFKAQIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BD07</accession>
    <name>A0A3S1BD07_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Basal body-orientation factor 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Coiled-coil domain-containing protein 176</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_006756</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BBOF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000168">
        <property type="protein sequence ID" value="RUS85480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BD07"/>
    <dbReference type="STRING" id="188477.A0A3S1BD07"/>
    <dbReference type="OrthoDB" id="441129at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032777">
        <property type="entry name" value="DUF4515"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14845:SF5">
        <property type="entry name" value="BASAL BODY-ORIENTATION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14845">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING 166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14988">
        <property type="entry name" value="DUF4515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4515" evidence="12">
        <location>
            <begin position="79"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="48"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="241"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS85480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="457" mass="53359" checksum="7B8357D0DB7F0C49" modified="2019-04-10" version="1" fragment="single">MPKKGKKGKKGKKGKKGKKGAKKESVVALAAANSKVWEARLTIAENSKQEFRENAKKLMFENDALQSQMFQTERDTIDVITFLKKQDQEKDTQLERLQQQMRDTKKDHRKEKEGIVEDFSKQVNELESRLADKTREVDLMHSELKLVKEFRRKRGQMQKELEDIKETMHNANRDHKATLGRMEQKFFEEKMRLQQEANQKIAELAEKAHTQAIANLDETTKSVYKENVRLSEALNYHMKEGELLTKERDRLLEENNNFREEKEVTDLMVQEKVVQVKQQKEAIKELSDKIKILEKSLSHVVREFDTEKKSIVARAETENSAGQVEISKLQRVIELKTREMNKVKRLAKNILDERTELERFFLESLEQVKSEVAANQSQYRKDAHAAYQKRMLAAHAGKGDFPKIRTFNPSEHSTNSVFRDVEAAEILYDTSGKVDISELTWEQKERVLRYLFAKMNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BEP4</accession>
    <name>A0A3S1BEP4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_013167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000473">
        <property type="protein sequence ID" value="RUS79062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BEP4"/>
    <dbReference type="OrthoDB" id="6147660at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018586022" evidence="1">
        <location>
            <begin position="23"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS79062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="125" mass="13121" checksum="194159A7CABC3920" modified="2019-04-10" version="1">MRIPTCVLLSCLACLGLDVAQGADIVLCQQACGTPPEKTSESTLLLQHLCGCIKDATSDPFAFLDKTTPTDATTSPPPTTTKAPTLRYKITTTTAEPVTSICDYLCAHQMGGDACRCSNPSLPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BFH7</accession>
    <name>A0A3S1BFH7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_012691</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000444">
        <property type="protein sequence ID" value="RUS79561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BFH7"/>
    <dbReference type="STRING" id="188477.A0A3S1BFH7"/>
    <dbReference type="OrthoDB" id="6244967at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051622">
        <property type="entry name" value="R-tyr_protein_phosphatases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24051:SF9">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24051">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="83"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="185"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="369"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="385"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="423"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="457"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS79561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="489" mass="56298" checksum="8435AF420FF22690" modified="2019-04-10" version="1">MCESCCAVICRQIQFWERNKRALTAREVDFEPNQVESLAGNTYKVRVDKIIPFTNMEAQVAVRNNFYIGSPSQVVNFRTEPGLPGVVEYLRVLNIGDCVHLDLTRRGLENRGDLTGYDISYRVVQGLDLGVMQDREPQINDPYTTNAYLSGLSPSTRYRVYIYARTMQGRGEAYFIEIVTAQPGTPRMPRFTIENVGHTFINVSWWVNAFADSGTVVYVEYRKLYGAEWLRTTDEVVNTWKNVSNLEPGTRYELRIKATNGKISIASGIDEIVTDGNAKAYDLISNIGWFLGMLFSVLFIIGFLVFLVLLYRSGFRFSYSPVGGQGGARSLEPYSDTARVAAEKDFGPEPKGYSNDYYDDKDYHNYDYDDGGFNRPPSYSSRNGSNEEKRRSDEYEDFDRREPQNGRYYDRDDPGKFDQYGAPRDDYRDDYRDDYRDDYRDDYRDDHRDNYEDDHYEDDRRDYYGDGGRHVPSAPPSTSSEKPGASTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BH81</accession>
    <name>A0A3S1BH81_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_004017</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000089">
        <property type="protein sequence ID" value="RUS88251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BH81"/>
    <dbReference type="STRING" id="188477.A0A3S1BH81"/>
    <dbReference type="OrthoDB" id="6156699at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005112">
        <property type="term" value="F:Notch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000373">
        <property type="entry name" value="sushi, nidogen and EGF-like domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050906">
        <property type="entry name" value="Notch_signaling"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24044">
        <property type="entry name" value="NOTCH LIGAND FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24044:SF417">
        <property type="entry name" value="WEARY, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23106">
        <property type="entry name" value="EGF_Teneurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018672123" description="EGF-like domain-containing protein" evidence="6">
        <location>
            <begin position="19"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="22"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="63"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="119"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="120"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS88251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="171" mass="18887" checksum="6655D3CE00D3E182" modified="2019-04-10" version="1">MATRTCLFLISLFACSQALLLNRDPCSQIVCENGGYCLAPADYPTCVCPYGYTGKRCELIQVTRDPCVHFVCQNAGTCTAPADRPYCLCQPGFTGTHCELTDSDMSGHGRVSTIMAILCDNDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BJH7</accession>
    <name>A0A3S1BJH7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_009907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000291">
        <property type="protein sequence ID" value="RUS82317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BJH7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS82317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="104" mass="12270" checksum="ADA73EEA7E540745" modified="2019-04-10" version="1">MDMVGDRGMVMDRVRAMVRVGDRGMVMDRVRAMVRVRVRVRVSFRVRVRVRVRVRVRVRVRVRVSFRVRVRVRVRFRVRVRAMVPLGFGIWLGIGLGIWLGLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BLQ1</accession>
    <name>A0A3S1BLQ1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_000931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000014">
        <property type="protein sequence ID" value="RUS91317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10664701at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="160"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="244"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS91317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="244" mass="28226" checksum="3C9827C2A0EE8162" modified="2019-04-10" version="1">MDFPRKCKTKRKNPGKTLGLPKLDTLTQLEREQLYHQNFQELAALRRNVYSSLNIHPRNTYLPPQLKPTSVVRPSQQEPQKHQESASGTAATHLHQPQRDQASGAITTYQQQPQQQKQQRDLGIQRHDEQMQINKKQKHAPQYHHQQQHKEPKQHGQFREGSNTVMQSGLYDRSEKAAMNNGKDLSENRNYFNTPGRTNGASYMPAFEQEKPPPQPEIFVKVDEGSDSDFSSMMDTDSSEYERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BN72</accession>
    <name>A0A3S1BN72_ELYCH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">EGW08_000103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
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            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000002">
        <property type="protein sequence ID" value="RUS92079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BN72"/>
    <dbReference type="OrthoDB" id="6157320at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="676"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="784"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="879"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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    </feature>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="RUS92079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="907" mass="99625" checksum="CB2631DA77153475" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
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    <name>A0A3S1BP29_ELYCH</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">EGW08_020783</name>
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        <name type="synonym">Sea slug</name>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001208">
        <property type="protein sequence ID" value="RUS71452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
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    <feature type="chain" id="PRO_5018760957" evidence="2">
        <location>
            <begin position="21"/>
            <end position="540"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        <location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="528"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS71452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="540" mass="55795" checksum="9986A6D57E68F029" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BP89</accession>
    <name>A0A3S1BP89_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        <name type="common">Eastern emerald elysia</name>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="RUS88295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BP89"/>
    <dbReference type="OrthoDB" id="6162923at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS88295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="221" mass="23467" checksum="C278A3210C991B74" modified="2019-04-10" version="1" fragment="single">MNGGGIDLDSDDTDSVGTPGGSPAKGRARLKRGPSVESAMQSFGLHSPDNWPEGADVDFIDINCLDGLDGLDGSEGGDNIPPDETVEAFNPAYSQSGYHSRRQLYLDPDIIDLTNFPPPETPDDDSILDFTELSNFLPPEFPEANSPESGFAKTDPDLLAVDVDALIAQFTIPPPPTSTIPDAGSPARTRSFPGPAQRYQTSGASSGSSPDRLENFNNKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BQL5</accession>
    <name>A0A3S1BQL5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Dynamin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_003089</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
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        <lineage>
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            <taxon>Lophotrochozoa</taxon>
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            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000064">
        <property type="protein sequence ID" value="RUS89146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BQL5"/>
    <dbReference type="STRING" id="188477.A0A3S1BQL5"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09913">
        <property type="entry name" value="EHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000147">
        <property type="entry name" value="EH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000038">
        <property type="entry name" value="EH domain-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040990">
        <property type="entry name" value="DUF5600"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031692">
        <property type="entry name" value="EHD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF31">
        <property type="entry name" value="AT21416P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18150">
        <property type="entry name" value="DUF5600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16880">
        <property type="entry name" value="EHD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="13">
        <location>
            <begin position="55"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="11">
        <location>
            <begin position="450"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="12">
        <location>
            <begin position="482"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS89146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="543" mass="62172" checksum="C784954891C537D0" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BQN3</accession>
    <name>A0A3S1BQN3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_003120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0389 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000065">
        <property type="protein sequence ID" value="RUS89112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BQN3"/>
    <dbReference type="OrthoDB" id="8193498at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009432">
        <property type="entry name" value="DUF1075"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13674">
        <property type="entry name" value="GROWTH AND TRANSFORMATION-DEPENDENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13674:SF5">
        <property type="entry name" value="UPF0389 PROTEIN CG9231"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06388">
        <property type="entry name" value="DUF1075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS89112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="139" mass="15680" checksum="403735481287B849" modified="2019-04-10" version="1">MMIMCKSLARFSAAESFMSNLRTSYRQIGSRKLQYPVSRQSISLRCLSNETSGISGATLKPTPFQQKILVWGKMYPSVDKVPDRVSRGQVKKAMDIFRVRSSICMAAMVFVFAAVMAMIGRKQRQDGMSITKIALEKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BT48</accession>
    <name>A0A3S1BT48_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_004170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000093">
        <property type="protein sequence ID" value="RUS88117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BT48"/>
    <dbReference type="OrthoDB" id="6046087at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="74"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS88117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="183" mass="19387" checksum="034FF3584C86907E" modified="2019-04-10" version="1">MIASPYSSNCGSVVYAANLQRCMPGSQASLELPAPDSETEGALYSSNLGCDTSDGFSLVSAFGLLACLKTLPIQNFATQRAECEALGGFLASARSIEKLLLVQDFTNGVSAWMGLDDQLEEGKLVWHDTGLQLTSSEHGATFAAGEPSNGGGVEHCIINNFFTRLNDVSCTMTYPAVCERPMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BU24</accession>
    <name>A0A3S1BU24_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Autophagy-related protein 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_017342</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG13 family. Metazoan subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000789">
        <property type="protein sequence ID" value="RUS74896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BU24"/>
    <dbReference type="STRING" id="188477.A0A3S1BU24"/>
    <dbReference type="OrthoDB" id="70161at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040182">
        <property type="entry name" value="ATG13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13430:SF4">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="329"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS74896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="493" mass="54225" checksum="B8FF5EAB46241269" modified="2019-04-10" version="1">MAASISTLDDSIENIERLFKKFTLKCLQVIVNSRIEANLLRSNKDFNEFFNIYVPDNPAIEDSLKKSLKDIKTFPPKCPICVEVALVTSEGDHMFLETWDLAFNRSSLDMSANRRQHIFTRMGVTLKSLLSATRALPAYKLARNQGEKGGGYTLTHRVYLAKPQTHMLGEGFKTVRAGAVPTAHGLLTVTVSYRTKLLLSADMSVPAAAEIEVEENHFMREAQELTGRQISPKPSNPLPCSSPIQSPVGRAESPYCFAVSPSSLEREDRAMRARAEAESSPWAKSSTLSMDELPEPVIGAFSCQQPSQRRSVEPEVPFEGLMRRSFFARQERKSPADLSSQRGGAGAEILQDKEDGDEKENIPRESAAQNVFSLRGGASTTEDEFVMVDKPPFAEEDDPGDVKAFLSAMMRAPKLYENYGDTETYGLDGTSGNSGNGNPQPAVSVGQYLSDVEELVSRLEEDMPVLDEFCNSVINMDSGEEGEEGDGAGFLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BV16</accession>
    <name>A0A3S1BV16_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_002754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000055">
        <property type="protein sequence ID" value="RUS89457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BV16"/>
    <dbReference type="OrthoDB" id="6134577at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS89457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="463" mass="49303" checksum="8F40B4884D14F26A" modified="2019-04-10" version="1">MLPKEPQLAAMSVADDREEDLIDGAELPPAPSPDSTKSEPIRGVLSRAGESDVISIISEANSFKSSKSKKRVQFLPEGLMVRVREIPPRSNKSSSESDGSASDTSSESDGSEDESEDTSSGSRTPSPAQSVSATTFTTMPPLVWNPSNTAKGSYTVAKQTTRAFSTVAKITGIHHRTVSPASASGGAAKNSPRRARRTPSPKLEKRTKKTSPKLTEKTPVSVSIKSLEPPARSKSVRKSSQPRKDGKISPPTNTHKQTAKAKQSSVTTSNNIKFTTTATKVTLASRRVSSAPPVKLIPPKRGGYPSTGSTSVTLLPSTQTAGQQHQTPSSSMDRVGRAMQSLTMGQLYTIDGFIFPSHQAPEVHLPDVMAPYKTDGTGSNSGAVSRLLSPRRSLDSTVSLHGGINQQGQTPPMSATRKKRYAWQMAEGGAQSTLNNTPSIAQLWDHDTSNASRALSNGHSHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BXR8</accession>
    <name>A0A3S1BXR8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">POPDC1-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_014612</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000566">
        <property type="protein sequence ID" value="RUS77612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BXR8"/>
    <dbReference type="STRING" id="188477.A0A3S1BXR8"/>
    <dbReference type="OrthoDB" id="425611at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051146">
        <property type="term" value="P:striated muscle cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006916">
        <property type="entry name" value="POPDC1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055272">
        <property type="entry name" value="POPDC1-3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12101">
        <property type="entry name" value="POPEYE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12101:SF30">
        <property type="entry name" value="POPEYE DOMAIN-CONTAINING PROTEIN 3-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04831">
        <property type="entry name" value="POPDC1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="POPDC1-3" evidence="6">
        <location>
            <begin position="30"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS77612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="351" mass="39773" checksum="A387A43F3A903878" modified="2019-04-10" version="1">MMCLGVELVESQTRSMLESLRGCSSWQPTNHVLYHLANVMLCIGLMVPDSSYGALLLHGFMFLGYLLMSVWSWVILCAPDFFSWNFAFLLLNGVQTLSLMYSVRPVKFCDEIEAVYVALFLPLRVSRHLYKRLVCPEFCTIMTLHEGETYATQSVTRTDKLGLLISGTINKSEVIIHNQCVPSAHRTGPPIPATWSRGSMHAYSNRSLLHVIGEKQFIDSPEFESTTTGDAKFQVSIVAASMCRYLFWPRQHLEYLLIKEPHLASVMKTIIGRDVTNKLYALNEKVSNPEGRRLDIRLPGIPGCLRDRKCLKMTSPEVRINTIEASDENDLDKMSDADEYKSKDKFSSKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BY46</accession>
    <name>A0A3S1BY46_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_014344</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000544">
        <property type="protein sequence ID" value="RUS77913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BY46"/>
    <dbReference type="STRING" id="188477.A0A3S1BY46"/>
    <dbReference type="OrthoDB" id="10249149at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000002">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="12">
        <location>
            <begin position="49"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="13">
        <location>
            <begin position="248"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS77913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="451" mass="50222" checksum="6B928C914FECF389" modified="2019-04-10" version="1">MRECISIHVGQAGVQMGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGSGKHVPRAVFVDLEPSVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTVGKEHIDITLDRIRKLADQCTGLQGFLIFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFAVYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPSYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVPEITNACFEPANQMVKCDPRHGKYMACCMLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGVDSVDAEAEDEEEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C016</accession>
    <name>A0A3S1C016_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_012949</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000460">
        <property type="protein sequence ID" value="RUS79294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C016"/>
    <dbReference type="STRING" id="188477.A0A3S1C016"/>
    <dbReference type="OrthoDB" id="206339at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060287">
        <property type="term" value="P:epithelial cilium movement involved in determination of left/right asymmetry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055289">
        <property type="entry name" value="OFD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39063:SF1">
        <property type="entry name" value="OFD1 CENTRIOLE AND CENTRIOLAR SATELLITE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39063">
        <property type="entry name" value="ORAL-FACIAL-DIGITAL SYNDROME 1 PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16045">
        <property type="entry name" value="LisH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="560"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="699"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="826"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="887"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="231"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="375"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="497"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="713"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="737"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="826"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="848"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="887"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="910"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="968"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="998"/>
            <end position="1008"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS79294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1008" mass="117222" checksum="3014BA6C7171E71C" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1CBY3</accession>
    <name>A0A3S1CBY3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_003726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000081">
        <property type="protein sequence ID" value="RUS88468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1CBY3"/>
    <dbReference type="STRING" id="188477.A0A3S1CBY3"/>
    <dbReference type="OrthoDB" id="6153764at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS88468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="192" mass="21291" checksum="6AB431DC4DAFD4DE" modified="2019-04-10" version="1">MSVHTRTLGVTEHVNTHRTLGVTEHVNTHRTLGVAEYVITSRTLGVTEHVNTHRTLGVTEYVITSRTLGVAEHVNTHRTLGVTEYVNTHRTLGVAEYVITSRTLGVTEHVNTHRTLGVTEYVSTHRTLGVAKHVITSRTLGVTEHVNTSRTLGMTEHVSTSRTLGVTEHVKRQRPLLSKAFIRMGIGIEPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H155</accession>
    <name>A0A3S1H155_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_022116</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001486">
        <property type="protein sequence ID" value="RUS70124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H155"/>
    <dbReference type="OrthoDB" id="6146816at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050801">
        <property type="entry name" value="Ca-Dep_Lectins_ImmuneDev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801:SF63">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801">
        <property type="entry name" value="LITHOSTATHINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018661649" description="C-type lectin domain-containing protein" evidence="2">
        <location>
            <begin position="31"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="140"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS70124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="261" mass="28498" checksum="24E556C7518FADB5" modified="2019-04-10" version="1">MVLRNMRDFEIMLSVVVLVLCMIKPAKLTAQDPLTDLKFSVTDPTSVSPLVPYRLTSPGWTGMSSVLACAQRTVSTYPESRGFLYNSVSGLCTPLFWLQGPGADNATGVTSQEGAMYLAKDVCPQDFQVLEYGSKGQLACIKDSTDSQNYGDATSACNALQSRLVAVRTAEKLELVRSISGGDDKWVGLDDLVEEGKMVWQIDGGTMIQEERDAIFPSHEPNDMKGNEDCVQFRGSTQLLNDKSCDEKHGFICEVALPGFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H1T0</accession>
    <name>A0A3S1H1T0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LRRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_021737</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001394">
        <property type="protein sequence ID" value="RUS70497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H1T0"/>
    <dbReference type="STRING" id="188477.A0A3S1H1T0"/>
    <dbReference type="OrthoDB" id="6156376at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF30">
        <property type="entry name" value="LRRNT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018594937" description="LRRCT domain-containing protein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="692"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="LRRCT" evidence="7">
        <location>
            <begin position="630"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="775"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="970"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1034"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="803"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1036"/>
            <end position="1045"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS70497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1079" mass="121415" checksum="2CB7175D9138F2A2" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HAD1</accession>
    <name>A0A3S1HAD1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kazal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_016888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000749">
        <property type="protein sequence ID" value="RUS75343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HAD1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018578285" description="Kazal-like domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS75343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="11803" checksum="A2A8ED7A80FBF638" modified="2019-04-10" version="1" fragment="single">MALSQMHVFVLILFLICDVPCGSGFSKITQKLEKDLKKAQNLLESHNCSHTVDDCGNRFIPDKPRCSDFERTGKCMLNECLGIKGTGDEKTVAAILTKYINAIDYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HJ97</accession>
    <name>A0A3S1HJ97_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Helicase, lymphoid specific</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_011672</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000384">
        <property type="protein sequence ID" value="RUS80578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HJ97"/>
    <dbReference type="STRING" id="188477.A0A3S1HJ97"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006346">
        <property type="term" value="P:DNA methylation-dependent constitutive heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000015">
        <property type="entry name" value="lymphoid-specific helicase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47161">
        <property type="entry name" value="LYMPHOID-SPECIFIC HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47161:SF1">
        <property type="entry name" value="LYMPHOID-SPECIFIC HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="65"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="440"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS80578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="655" mass="75070" checksum="401BE77D83C57B38" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HXE9</accession>
    <name>A0A3S1HXE9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA polymerase II assembly factor Rtp1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_004142</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Tango6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000093">
        <property type="protein sequence ID" value="RUS88089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HXE9"/>
    <dbReference type="OrthoDB" id="39591at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019451">
        <property type="entry name" value="Rtp1_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039600">
        <property type="entry name" value="TANGO6/Rtp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959:SF1">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10363">
        <property type="entry name" value="RTP1_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase II assembly factor Rtp1 C-terminal" evidence="3">
        <location>
            <begin position="149"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS88089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="414" mass="45177" checksum="C088BF5526876B82" modified="2019-04-10" version="1" fragment="single">MCQACADEETAAFEWETVAMAMGLLTTVLSGGLELGDQTELLDELLPLMTFISDSKAADPRVKEMADDLKVAVATKGLVWAELSQMREERRNNKDPRSSKEETKTKKLIEVLSETSGEEDVKELIKQRKASKESGKETSADPATGVTQLEQALQELCDPMLPVRGHGLIALARLVEDRSPEVHDKQEVLLKVFLENLSHTDSYIYLAAVNGLAALADLCPDRVIPCLTSELRSKCENTTEGSGDEKSSESLVLKVSEALVKATRRLGEMTPKYRDLLLPAILCSCRHGDPLTRASCLSGLAEVCQRLHFALGPVLYEVITCCRDVLTSDPDPEPRKAAAMTFALILRGLGKDTLTALGGALIDVYRSLKRAAATDPEEGVRVHAALALDELDGTMREMLFARPELSKQISILGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SI31</accession>
    <name>A0A433SI31_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Core Histone H2A/H2B/H3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_023801</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the histone H2B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01002854">
        <property type="protein sequence ID" value="RUS68439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SI31"/>
    <dbReference type="STRING" id="188477.A0A433SI31"/>
    <dbReference type="OrthoDB" id="6256412at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000016">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="11">
        <location>
            <begin position="17"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS68439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="122" mass="13652" checksum="2434F5A41D858A58" modified="2019-05-08" version="1">MPPKVSSKGAKKAGKAKAVRTGDKKRKRKRKESYSIYIYKVLKQVHPDTGISSKAMSIMNSFVNDIFERISAEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVREGTKAVTKYTTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SIW1</accession>
    <name>A0A433SIW1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Vesicle-associated membrane protein 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Synaptobrevin-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">EGW08_023298</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">EC2010</strain>
            <tissue evidence="19">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle</location>
            <location evidence="12">Phagosome membrane</location>
            <topology evidence="12">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasmic vesicle</location>
            <location evidence="9">Secretory vesicle membrane</location>
            <topology evidence="9">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Golgi apparatus</location>
            <location evidence="8">trans-Golgi network membrane</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Late endosome membrane</location>
            <topology evidence="10">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Lysosome membrane</location>
            <topology evidence="11">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001914">
        <property type="protein sequence ID" value="RUS68940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SIW1"/>
    <dbReference type="STRING" id="188477.A0A433SIW1"/>
    <dbReference type="OrthoDB" id="248747at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030658">
        <property type="term" value="C:transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15871">
        <property type="entry name" value="R-SNARE_VAMP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000015">
        <property type="entry name" value="Synaptobrevin 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051097">
        <property type="entry name" value="Synaptobrevin-like_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136">
        <property type="entry name" value="SNARE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136:SF179">
        <property type="entry name" value="VESICLE ASSOCIATED MEMBRANE PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="17">
        <location>
            <begin position="7"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="18">
        <location>
            <begin position="124"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RUS68940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="219" mass="24888" checksum="BED804BD16D863C9" modified="2019-05-08" version="1">MPILFSVVARGNTVLAKYASCAGNFTEVTEQILSKIPQGNSKLTYSHGSYLFHYVTEDKITYLCITDDEFERAKAFMYLNDIKRRFQSQYGVRAQTALPYAMNSDFSRTMSTQMRVVSDKKPDTLNKVQDQVEELKGIMVRNIDQLAERGERLELLVDKTEDLSANSVTFKKTSRNLARSMWWKNVKLMVIISVVVIILLYIIISASCGGLNWPNCTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SJ89</accession>
    <name>A0A433SJ89_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_023149</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001839">
        <property type="protein sequence ID" value="RUS69089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SJ89"/>
    <dbReference type="STRING" id="188477.A0A433SJ89"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22707">
        <property type="entry name" value="FHA_KIF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000020">
        <property type="entry name" value="Kinesin family member 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032405">
        <property type="entry name" value="Kinesin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117:SF5">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16183">
        <property type="entry name" value="Kinesin_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="10">
        <location>
            <begin position="83"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="6"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="202"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS69089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="457" mass="51725" checksum="3B5A96360102B6F9" modified="2019-05-08" version="1">MNEEALAASMSEIARLKNEMEEMSRSWQERLRQAEARKVEELKLLERAGVTLKVDNRLPNLVNLNEDPQLSEMLLYVIKEGETRVGRDIDDSRHIKLTGALIADKHCVINSCDGQVKISPLGEAPTYVNGNLISETTLLHHADRVILGGDHYFRFNHPMEVQKNKGSESREVKDFDFARQELLGVQEARLQAELQAVMEKTRQQLDHQKDGYESKLKGLKKVLTKVEETHKEAQSTIHTLQKQNMMLEQEVLAGRKRHKLESSLSQQSIEALSLSRSKIVELLETETKKVAARLDKFRSKRSELAAVPLCNSSVTSLLSSSSSSPDTSCDGGCQQQQQQLSTPSRRDLYKIALLVREANKINQYLNTNLVFSREDVSDDIGSTDQVLRTQIRVTNTRHCIFTLWTVGKFEEKLAQMRDLFQNEGDKSADDDKIFNDPEDVWETEQGISSSACIDPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SKA3</accession>
    <name>A0A433SKA3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_022660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001632">
        <property type="protein sequence ID" value="RUS69576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SKA3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS69576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="196" mass="21244" checksum="0806AF50C4250B94" modified="2019-05-08" version="1" fragment="single">MLTDAGVSGQHVGVLHHGLVRGRVLRDFQHAAPLGKAASSLLVLSTPFRQTVETWGRDQQHNALVEGPSKGNNTFVHLDSWDDALIFSLISNLDKGDSSSCALPKGLVKKDHTTDVVGYDVVCCEQELSVLATILVSVGEVDVLQTDNTMMIYLTNRLVGGQDSFAWSHNGIGNFAKLILLSRGEVGCESRCRLCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SKK5</accession>
    <name>A0A433SKK5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_022646</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001627">
        <property type="protein sequence ID" value="RUS69592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SKK5"/>
    <dbReference type="STRING" id="188477.A0A433SKK5"/>
    <dbReference type="OrthoDB" id="6274627at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000630">
        <property type="entry name" value="Zinc finger protein 180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000176">
        <property type="entry name" value="zinc finger protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="671"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="699"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="727"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="755"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="783"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="811"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="839"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="867"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="184"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="244"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="336"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="401"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="590"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="644"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="251"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS69592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1091" mass="120161" checksum="93751748FE5A7B0A" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SKM3</accession>
    <name>A0A433SKM3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Caspase family p10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_022564</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001609">
        <property type="protein sequence ID" value="RUS69675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SKM3"/>
    <dbReference type="OrthoDB" id="6093024at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Caspase family p10" evidence="2">
        <location>
            <begin position="41"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS69675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="117" mass="13436" checksum="51FA6407D04915A9" modified="2019-05-08" version="1" fragment="single">PSLRSDNLPESRHQLPPTHHSDQGPTSSPVDTRSARGADTSDMCFVHSSSYGYKAYRTTTRGSPFITVFTQKVIELARHKEFRDIIQKIQNHFNKEPLSNNKMTLPDFSVQLMNKWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SL66</accession>
    <name>A0A433SL66_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_022374</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001552">
        <property type="protein sequence ID" value="RUS69868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SL66"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS69868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="145" mass="16330" checksum="BDDCCDA78EFF624C" modified="2019-05-08" version="1" fragment="single">EPVVQKLQDDPDGLHVLPVKLNLLAVPGPLVLLHHRSQELLVEVRRDVDQEVHNVATEQIHYFLFCCYCCFLNINQCSSTDSVRANYLINRLLLHGDCEVEENLEDLGTQLHLLVSEPAGLGLSVPQGQVEDFHQVREAMQLVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SLE7</accession>
    <name>A0A433SLE7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GST C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_022277</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001527">
        <property type="protein sequence ID" value="RUS69960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SLE7"/>
    <dbReference type="OrthoDB" id="5809458at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03193">
        <property type="entry name" value="GST_C_Metaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026928">
        <property type="entry name" value="FAX/IsoI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF41">
        <property type="entry name" value="FAILED AXON CONNECTIONS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17172">
        <property type="entry name" value="GST_N_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01180">
        <property type="entry name" value="SUF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01200">
        <property type="entry name" value="SUF1.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin-like fold" evidence="4">
        <location>
            <begin position="60"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="3">
        <location>
            <begin position="198"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS69960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="33157" checksum="02B7CED6AC5E6947" modified="2019-05-08" version="1">MLELGFFNGVALLTMVVVIGVWRKRSKPKPMESFLVSNPPQDTVVLHQYGPALTVPSISPFVMKMETYLRAAGIPYVNKFDRWPGPKDKLPWIQYNHQVVADSQMCIEFLNQERCVDLNKKLSPSDWAVGHLLRRTCEESLYWALLMWRLVFDKDATIYNRMSIPKPVIWYMRRMSYGRLWSQGIGRHKEQEVTQIMEDDLSALSTMMGDHKFLFGDTKDCVSEFDCAVFGQLCQLVWQMPGCCVQETIAKKYPNLVSFCENMKAAFWPDWEDRLLKTVKKMNCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SLF2</accession>
    <name>A0A433SLF2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UPAR/Ly6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_022259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001522">
        <property type="protein sequence ID" value="RUS69980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SLF2"/>
    <dbReference type="OrthoDB" id="6110938at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019382079" description="UPAR/Ly6 domain-containing protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS69980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="15455" checksum="DC18AECB2AECE1D1" modified="2019-05-08" version="1" fragment="single">PARTVSLKTISALFFAGLMECLTCWHCIAENCDLDPASNFRAEKRQCMEGHLCQAMYFEMQSDIDDARYKSTVRSCAEQCEPRDDYQNCTRDLYITRGCVRRMCCHNNDLCNSAPKWTSASVVLVMLMAGSSAWLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SMK3</accession>
    <name>A0A433SMK3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_021818</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001413">
        <property type="protein sequence ID" value="RUS70419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SMK3"/>
    <dbReference type="OrthoDB" id="6078889at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS70419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="151" mass="17341" checksum="84C68500E225D0F4" modified="2019-05-08" version="1">MQGDSKTATCCQQYQAHSGQMFDWWRHSQDGRIVHTPEVAPPPPPFRPPPLRRDQLCWPMYQVSQFEGLGQEMAANTPTADPEHCEPSKDYWPDTETICVQQCYRKEHVRPPWIPPKNPKNTPCCGSAIPRPHSYTCAGRQKPVQPYLCRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SPC8</accession>
    <name>A0A433SPC8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_021172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001278">
        <property type="protein sequence ID" value="RUS71068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SPC8"/>
    <dbReference type="STRING" id="188477.A0A433SPC8"/>
    <dbReference type="OrthoDB" id="10461707at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039782">
        <property type="entry name" value="VPS13B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12517:SF0">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12517">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 13B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS71068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="131" mass="14546" checksum="8E26C1CB8D48E5D9" modified="2019-05-08" version="1" fragment="single">MQQPGDAPSAPYVLDFSQDDLRRGHFQFVESQNDSSLQPEPYEIAFSAGDPASNEGSSMTWCYPHPRILTGIILNPVPFCLSSKAPDEGSFAVIPCELQYWSELSSQFVGLIKIHLSENEPVKVTFPDPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SQ55</accession>
    <name>A0A433SQ55_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein arginine N-methyltransferase 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Histone-arginine N-methyltransferase PRMT6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_020847</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001221">
        <property type="protein sequence ID" value="RUS71392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SQ55"/>
    <dbReference type="STRING" id="188477.A0A433SQ55"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF73">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="8">
        <location>
            <begin position="272"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS71392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="450" mass="51063" checksum="7DD9EE1793FCA66D" modified="2019-05-08" version="1">MRGRGGDEKKTKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKTSNVEAPFFYNNSKIHGRTDAVNFTVLRQFNLRQGSPLTATLSSPLEPHTVPSHSAPDTMERVSNSLEDVQNGCSFEETCSHATEKPSVKKSKHIDDSDADYFRCYADIRIHEQMLSDKVRTLAYRQALLENKGKLKDSTVLDVGAGTGILSQFAIQAGASKVFAVEPTRIAHVAKQICSENGTDKSISVIQSKIEGYTLLYESMLQSVLWARDQYLKPDGEMYPCKASLFLAPINDEAVQERSNNWNHMKELYGVSMASLEPLTKQALTARADTLHLDMESVLANACRLCHFDLKTMSVQDAKLVQENFEFKCYGSSMMHGFATWFTVTFPGSVTIDTSPYALPTHWGQTVLYLKEPISVQQDTKINGSYRMQPSAENPRFWDIHVEFKVNRGEKISQQWQCAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SQ66</accession>
    <name>A0A433SQ66_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_020956</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001240">
        <property type="protein sequence ID" value="RUS71279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SQ66"/>
    <dbReference type="OrthoDB" id="412155at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051560">
        <property type="entry name" value="MAM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282">
        <property type="entry name" value="APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282:SF101">
        <property type="entry name" value="MAM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="2">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS71279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="144" mass="16342" checksum="F6F138C02A5738C7" modified="2019-05-08" version="1" fragment="single">TCQFEATFCDWELSDKDNLRWSFQAGPTPTRIGGKILTGPENDHTMGTSQGLTFLQLFCFGCFCFLIYTSLAKILKLYLYYMHGLSMGSLSVLMWSNGQDYPGPNAQSEWRVSGEKGDLWIYQKVSLRNSVTPYKVTSAYPSCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SRN7</accession>
    <name>A0A433SRN7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_020306</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001139">
        <property type="protein sequence ID" value="RUS71931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SRN7"/>
    <dbReference type="OrthoDB" id="10583428at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019574962" evidence="3">
        <location>
            <begin position="29"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="106"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS71931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="261" mass="29081" checksum="ADC5F415A4D447BD" modified="2019-05-08" version="1">MKQDNIFNAIAIAVSAAMLVASPSGVRGGELCEQDPYQRKSMCGSVLNALSEASTLYTFTRDRAVFLPIWMYDFVDPVNVLQKPQTVINHPNHLEKLSMVHKMTDVSEFQSEISKYNAELDRLFQALERYTTTWVYLAWEQSNLKFKSLVETLRQRLRAARNTVDDLEDSLVTMLHSQPAAATSASKPEAKNTVSASKTAPTTAATTSTSTTAAPESVDSIQQKASFVSKKLRNLLRLWASRCSSCGDSRRRRSVFVSRMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433ST99</accession>
    <name>A0A433ST99_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_019752</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001061">
        <property type="protein sequence ID" value="RUS72498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433ST99"/>
    <dbReference type="STRING" id="188477.A0A433ST99"/>
    <dbReference type="OrthoDB" id="10051637at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="6">
        <location>
            <begin position="535"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS72498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1051" mass="118018" checksum="39BE28D88034064A" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SU42</accession>
    <name>A0A433SU42_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_019429</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001016">
        <property type="protein sequence ID" value="RUS72805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SU42"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005283">
        <property type="term" value="F:amino acid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089718">
        <property type="term" value="P:amino acid import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037979">
        <property type="entry name" value="Na_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF321">
        <property type="entry name" value="SODIUM-DEPENDENT NUTRIENT AMINO ACID TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="573"/>
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            <end position="613"/>
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        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
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        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
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        <location>
            <position position="351"/>
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        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
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            <dbReference type="ChEBI" id="CHEBI:29101"/>
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        </ligand>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS72805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="655" mass="73830" checksum="141FC4C633947DAF" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SUJ3</accession>
    <name>A0A433SUJ3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_019398</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C65 family. Otulin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001011">
        <property type="protein sequence ID" value="RUS72833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SUJ3"/>
    <dbReference type="STRING" id="188477.A0A433SUJ3"/>
    <dbReference type="OrthoDB" id="6288034at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22790">
        <property type="entry name" value="OTU_OTUL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023235">
        <property type="entry name" value="FAM105"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33662:SF1">
        <property type="entry name" value="INACTIVE UBIQUITIN THIOESTERASE OTULINL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33662">
        <property type="entry name" value="OTU DEUBIQUITINASE WITH LINEAR LINKAGE-SPECIFICITY A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_C101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02055">
        <property type="entry name" value="PROTEINF105"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="198"/>
            <end position="241"/>
        </location>
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        <location>
            <begin position="311"/>
            <end position="331"/>
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            <end position="449"/>
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            <begin position="200"/>
            <end position="211"/>
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            <end position="228"/>
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        <location>
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            <end position="418"/>
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        <location>
            <begin position="602"/>
            <end position="629"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS72833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1002" mass="109655" checksum="FDFBD23C12D8121B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SXC8</accession>
    <name>A0A433SXC8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_018279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000881">
        <property type="protein sequence ID" value="RUS73964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SXC8"/>
    <dbReference type="OrthoDB" id="6120699at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS73964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="178" mass="18899" checksum="4E0F489C6F2A2DE4" modified="2019-05-08" version="1">MPSAARQRLPSELWRCGKSINSCSGPGNANSSSFAEMQVSPGHYDTISDEKQHYHSHKKGSGKLQKRNNQGRKSPKTLARKISGAGAISDPEMDILEKSFASTVALSSSVQSDSGIDYTAKSGSGDVYALDSLSAPDPSELPFPPLEWLQPSTGKTSPVSSNYGSFDLQTILACTAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T1M0</accession>
    <name>A0A433T1M0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_016790</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000742">
        <property type="protein sequence ID" value="RUS75440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T1M0"/>
    <dbReference type="STRING" id="188477.A0A433T1M0"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009313">
        <property type="term" value="P:oligosaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000250">
        <property type="entry name" value="Probable di-N-acetylchitobiase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051887">
        <property type="entry name" value="GH18_Domain-Containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46290">
        <property type="entry name" value="DI-N-ACETYLCHITOBIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46290:SF1">
        <property type="entry name" value="DI-N-ACETYLCHITOBIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0458">Lysosome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019165682" description="GH18 domain-containing protein" evidence="9">
        <location>
            <begin position="27"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="10">
        <location>
            <begin position="15"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="10">
        <location>
            <begin position="422"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="380"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS75440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="793" mass="89605" checksum="0A36C92D27887DA6" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T307</accession>
    <name>A0A433T307_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_016295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000698">
        <property type="protein sequence ID" value="RUS75949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T307"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23334">
        <property type="entry name" value="VWC2L_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019573907" description="VWFC domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="2">
        <location>
            <begin position="35"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS75949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="100" mass="10653" checksum="DD4F73FA2A70710C" modified="2019-05-08" version="1">MQAVVGLTLILVGLTFAVPRSPLFVEYTPEKDSNKPCTLPDGSTLPIGETVQPDPCMHCTCLIAGWDAACATAMCALPLCELPHVVTYSKDHCCPYCAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T3A6</accession>
    <name>A0A433T3A6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin conjugation factor E4 core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_016227</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000693">
        <property type="protein sequence ID" value="RUS76022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T3A6"/>
    <dbReference type="STRING" id="188477.A0A433T3A6"/>
    <dbReference type="OrthoDB" id="20295at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF2">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin conjugation factor E4 core" evidence="7">
        <location>
            <begin position="392"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS76022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="707" mass="80024" checksum="EACB1017BEF1EC6A" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T411</accession>
    <name>A0A433T411_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Histidine kinase/HSP90-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_015954</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000675">
        <property type="protein sequence ID" value="RUS76282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A433T411"/>
    <dbReference type="OrthoDB" id="5426351at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
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    <sequence length="2702" mass="296521" checksum="4EF93E55092D8802" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T8I9</accession>
    <name>A0A433T8I9_ELYCH</name>
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        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="9" type="ORF">EGW08_014404</name>
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    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">EC2010</strain>
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        </source>
    </reference>
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    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="term" value="P:chloride ion homeostasis"/>
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        <property type="project" value="TreeGrafter"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="7">
        <location>
            <begin position="1"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="8">
        <location>
            <begin position="520"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="655"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="670"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="690"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="706"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS77830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="956" mass="105728" checksum="9E9C8A12F47D5C09" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T8J9</accession>
    <name>A0A433T8J9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_014343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000544">
        <property type="protein sequence ID" value="RUS77912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T8J9"/>
    <dbReference type="STRING" id="188477.A0A433T8J9"/>
    <dbReference type="OrthoDB" id="10672512at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS77912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="165" mass="19172" checksum="8897204E2C0C3F5B" modified="2019-05-08" version="1" fragment="single">RETRSSHIYMYSRETRGSPIYMYSRETMCSPIYMYSRETRGSPIYMYSRETMCSPIYISLHKTSGSSIYMSSRETRGSHIYMYSRETRGNPIYMYSRETMCSPIYISSHKTSGSSIYMSSRETRGNHIYMYSRKTKVVLPTCTHVKQCVALSTFTNVKKGVAIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TAH7</accession>
    <name>A0A433TAH7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_013676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000502">
        <property type="protein sequence ID" value="RUS78569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TAH7"/>
    <dbReference type="STRING" id="188477.A0A433TAH7"/>
    <dbReference type="OrthoDB" id="90756at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36489:SF2">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36489">
        <property type="entry name" value="PROTEIN-COUPLED RECEPTOR GPR1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="163"/>
        </location>
    </feature>
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        <location>
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            <end position="188"/>
        </location>
    </feature>
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        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
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            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS78569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="565" mass="59002" checksum="1DA1908B45B72F84" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TCL3</accession>
    <name>A0A433TCL3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_013072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000467">
        <property type="protein sequence ID" value="RUS79164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TCL3"/>
    <dbReference type="OrthoDB" id="6191062at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019504689" description="SH3 domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS79164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="28632" checksum="FD9EB853E48B8EF6" modified="2019-05-08" version="1">MMGFSTRSLAVLLVVALVGLSLTEARKGRGGGGGRGARHGSEEDSDSKGSSERGPGRHEQGSSGSDEERSSGSSSESHEQRGSRGHEQRGHGGEGHRQRGHGGESQGHKGPEGPGGSSEMSEIEIPDGELYAWNQTLSTGDVVVERVFVPENKSLMVVSSRGNQEAGFVPARTLYDFSGPRAGTQNATAYGQENLDGTSEKLPLDATAALYEAKPELKRFCGLGGVVIAAPLGDLPAFEGETRNITVLTYDSEVTLTVPVGIQGRHGRGHPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TEL8</accession>
    <name>A0A433TEL8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_012238</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000416">
        <property type="protein sequence ID" value="RUS80004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TEL8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS80004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="226" mass="24886" checksum="58A7D0ECB2E46D21" modified="2019-05-08" version="1" fragment="single">MDGQNIPPSTDSTAQIPIFDHNISVSPDSIPQTIKDNHSIPPPPDSTAHVPNIDEIIPLPPESTCQITKVPSCGIEETPSAEDTHSIHPDSAGVSRSEVLFNRGRAGCCQFRQKQTALSQGESNRSSPPDRKLRGKQTRNNCGNCWSTKTNSTLRRERKKRTTLLTLVILTLGVCSMNLPFTLYMIWCGSLKTLEDKVDLFHSPYGSVPIVLVGTQTALNPYVYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TF53</accession>
    <name>A0A433TF53_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_012072</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000408">
        <property type="protein sequence ID" value="RUS80149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TF53"/>
    <dbReference type="OrthoDB" id="6120220at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019284037" description="Ig-like domain-containing protein" evidence="3">
        <location>
            <begin position="17"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="170"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="403"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="465"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS80149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="580" mass="64603" checksum="D69ECC301AAD3590" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TFK6</accession>
    <name>A0A433TFK6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_011864</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000395">
        <property type="protein sequence ID" value="RUS80367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TFK6"/>
    <dbReference type="OrthoDB" id="6196941at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS80367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="150" mass="17314" checksum="EFC2C8E0AADCE327" modified="2019-05-08" version="1">MSIENKEKSLGSSGRGARYLWGLRAQRVKSPWKSETGESIRYCDVMWFSYGEEIDETKPTEHKGQVCCRYTCSPFENWKKVPIFKRNQTATAHVSLKYRQCLGVKAPKLRDLQALGKKKVLPEYAVEFYNSLTVMGEGVDNENDEDYDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TJI4</accession>
    <name>A0A433TJI4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_010531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000323">
        <property type="protein sequence ID" value="RUS81724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TJI4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS81724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="19206" checksum="9A3CB4163FBC71DD" modified="2019-05-08" version="1" fragment="single">YLSTYLPIYLSTYLPIYLSTYLPIYLSTYLPICLSIYLSIYLSIDLSIYLPIYLSIYLSIYLSIYLSIYLSIHLTISHSLTLSLSLSLSLSIYPYIYLSIYLSIYLSIYLSIYLSIYLSIYLSIYLSIYLSIYLSIYLSIYLSIYLSIYLSIYLSILSTSHSLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TKI6</accession>
    <name>A0A433TKI6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_010131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000302">
        <property type="protein sequence ID" value="RUS82119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TKI6"/>
    <dbReference type="OrthoDB" id="6045352at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS82119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="33227" checksum="7EBCA14C8B1F7CFA" modified="2019-05-08" version="1">MLQNMDKGFIECEFFEDASAALEGSSSWASCTKNGGHLGFIPYPDFQIGHLPSAWQRREVFQETVDLAERTVKLTIGHTSTDRPDVFRFSNLNRPGIVRSGSGWMEKVVHRSDVPCPCSDCSRDGVTPQETWFEAVVITARHVVFNEEEAKSTLVDLHYDTKESRKDGSMQRLQAYCFLLSEGVEDACSLACAAHDIKKAQLEFPLQLTLIPSTKPNIGKTDLCVVISHPHGNPKKITLGEVKDFNPSGSEFLVRYDSGTCPGSSGAPVIVFYEDGNSLVVHSMGNVTDGINQGSCVAFKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TKK1</accession>
    <name>A0A433TKK1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inositol-pentakisphosphate 2-kinase</fullName>
            <ecNumber evidence="2">2.7.1.158</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_010101</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20313"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.158"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.158" evidence="2"/>
    <dbReference type="EMBL" id="RQTK01000301">
        <property type="protein sequence ID" value="RUS82127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TKK1"/>
    <dbReference type="STRING" id="188477.A0A433TKK1"/>
    <dbReference type="OrthoDB" id="6160419at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035299">
        <property type="term" value="F:inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004210">
        <property type="entry name" value="BESS_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009286">
        <property type="entry name" value="Ins_P5_2-kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF64">
        <property type="entry name" value="DORSAL INTERACTING PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02944">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06090">
        <property type="entry name" value="Ins_P5_2-kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51031">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MADF" evidence="4">
        <location>
            <begin position="137"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="BESS" evidence="5">
        <location>
            <begin position="394"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="244"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="284"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS82127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="446" mass="49831" checksum="F0BFBE8AFC28FA1F" modified="2019-05-08" version="1" fragment="single">DNVTAHASNDLIQTKVPKKAQRTSIDDACCQSKQLSNGSSTCDEANPTLMVGEAGKVSSEGGCENTCGEWTNHVDQQDFTLSFEIKPKKAYMTSKTSGTGKAQVCKFCMHQCLKGGLLKSSTGTERKENMSPQETETLIREMEKRSLLWNTKSPFYKDQSKRMDAWREIARAVYPDITPKGKIAEVKKVKDLQARWKSMRDSYTKYMRRLQINGDSSHSKYKPYVYAPQLAFLEKVLSFRLEKRDNKDQQAKPDSQQQEGELEEPESEETPEDMEGEDSGAPNIASSIKGDSSVSTITSSIKGESSVPNITESSSPDLAESSSYIEPTHKHSQKLRISLGSFKPDPDAESSQNLDGASETFTNMHRQSAMEENDFRVLEDVVQRIVKKEVGMENEPDMAFFNMLLPTLRNFTEDQKLEFRTEVLLIMRAIKAGTNKTALAGSSGDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TKR6</accession>
    <name>A0A433TKR6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA repair protein RAD52 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_010141</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RAD52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000303">
        <property type="protein sequence ID" value="RUS82096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TKR6"/>
    <dbReference type="STRING" id="188477.A0A433TKR6"/>
    <dbReference type="OrthoDB" id="206565at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010792">
        <property type="term" value="P:DNA double-strand break processing involved in repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.80:FF:000001">
        <property type="entry name" value="DNA repair protein RAD52 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.80">
        <property type="entry name" value="DNA repair protein Rad52/59/22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004585">
        <property type="entry name" value="DNA_recomb/repair_Rad52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041247">
        <property type="entry name" value="Rad52_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007232">
        <property type="entry name" value="Rad52_Rad59_Rad22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042525">
        <property type="entry name" value="Rad52_Rad59_Rad22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00607">
        <property type="entry name" value="rad52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132">
        <property type="entry name" value="DNA REPAIR AND RECOMBINATION PROTEIN RAD52, RAD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04098">
        <property type="entry name" value="Rad52_Rad22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="181"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="272"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS82096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="382" mass="41919" checksum="015FDE7461094F76" modified="2019-05-08" version="1">MAESTSFGQQEYTLEEEVALQRSLRQRLGPEFISQRTGAAGLKLAYIEGWRLTNLANETFGFNGWSHSVTQQTVDFVDFINGKFYVGVSALVRVQLKNGAFHEDLGYGVSEGMKSKGQALEKAKKESVTDGLKRALKSFGNSLGNCLGDKDYLKCINRAPKPPAQTYNVCDMKRQLEDPLINRSRVLRKRSAPTGGAAPKTWSASNQAPAGEVDMPAPPAPPVKEELSSSVTDASASRMSEGSDTSSFPRRNSEPVLGEKSLRSSSSSDPDITEKARKERLMKVEQKKKAFQASLDKTEMGPPDVKSATTTNKINRRDVLIEKDDYDEIDLWSQAVYAEDLSALDSLAMDSALEDKELSIVQSDGPGISDLKKRRISAAPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TMX1</accession>
    <name>A0A433TMX1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_009337</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000266">
        <property type="protein sequence ID" value="RUS82914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TMX1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS82914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="357" mass="39956" checksum="F1B0204878085E5C" modified="2019-05-08" version="1" fragment="single">TCSLLCDVTRWPMSVLTTVDIAAVVVVAVGMVTVVGHRRGGRLHQAVVDAEDPLEGRAELLREPAVQDEVTGRLDGQQAVADEPEESHVIARTMHLRIEKIITRRMHLRIDEIRCVAHKEGDDDSHQHHGDFELLTRHYRSLARTVSQVVAQVARRSPDLHNKAHVQNHQHEQRDDSHEHSCRIDHDDVGVDLLVVQVHPGNGEHLLPSGQPLVRDLEVQKLRTTHDEADQGQQTDDDAGSLHLGENDWEKKTGEGRERERERERKKKTGGFLRLTGVDEEDCLFAAHVEVAVAQPVHQRADGQHTQEEQVAHGQRGQIAVGGRAHGLAAQDDHGHQDAQYAAQADDRLHHRLDEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TN80</accession>
    <name>A0A433TN80_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2HC/C3H-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_009212</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ZC2HC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000261">
        <property type="protein sequence ID" value="RUS83024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TN80"/>
    <dbReference type="STRING" id="188477.A0A433TN80"/>
    <dbReference type="OrthoDB" id="10255185at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049899">
        <property type="entry name" value="Znf_C2HC_C3H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026104">
        <property type="entry name" value="ZNF_C2HC_dom_1C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14649">
        <property type="entry name" value="ZINC FINGER C2HC DOMAIN-CONTAINING PROTEIN 1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14649:SF1">
        <property type="entry name" value="ZINC FINGER C2HC DOMAIN-CONTAINING PROTEIN 1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13913">
        <property type="entry name" value="zf-C2HC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52027">
        <property type="entry name" value="ZF_C2HC_C3H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2HC/C3H-type" evidence="8">
        <location>
            <begin position="648"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC/C3H-type" evidence="8">
        <location>
            <begin position="752"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="103"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="692"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="733"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="262"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="362"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="412"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="447"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="463"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="482"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="568"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="592"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="608"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="781"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS83024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="790" mass="90358" checksum="959B64002313045F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TP04</accession>
    <name>A0A433TP04_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Citrate transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_008941</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000249">
        <property type="protein sequence ID" value="RUS83319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TP04"/>
    <dbReference type="STRING" id="188477.A0A433TP04"/>
    <dbReference type="OrthoDB" id="44467at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071913">
        <property type="term" value="F:citrate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000007">
        <property type="entry name" value="Mitochondrial tricarboxylate transport protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF4">
        <property type="entry name" value="TRICARBOXYLATE TRANSPORT PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="35"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="135"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="231"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS83319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="323" mass="35770" checksum="3EA2AAD0C94473B0" modified="2019-05-08" version="1">MDRTGNNSFRSPFMRPNAHLMAASPNTEAVQNSKSKTLKGIIAGAITGGLEICITFPTEYVKTQLQLDEKSGAQKRYAGPVNCVTKTVKEYGVRGLYRGLSVLLYGSIPKSAVRFGSFEEFKKRLVGTDGTLNGQQRLVCGLGAGISEAIFAVTPMETVKVKFINDQTSANPRFRGFFHGVRCIIAEQGLRGVYQGLTATMMKQGSNQAIRFFVMETMKDWYRGDDKQMKVPTLVTGAFGAIAGTASVYGNTPIDVVKTRMQGLDAHKYKNTWDCAVQIMKHEGPRAFYKGTVPRLSRVTLDVAITFMIYDSFMHFFNTVWKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TPL8</accession>
    <name>A0A433TPL8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_008693</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000240">
        <property type="protein sequence ID" value="RUS83514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TPL8"/>
    <dbReference type="STRING" id="188477.A0A433TPL8"/>
    <dbReference type="OrthoDB" id="6428965at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11055">
        <property type="entry name" value="CYP3A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050705">
        <property type="entry name" value="Cytochrome_P450_3A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302:SF15">
        <property type="entry name" value="FATTY-ACID PEROXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="302"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="321"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS83514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="549" mass="62205" checksum="0915ABD9C169F7F9" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TPR9</accession>
    <name>A0A433TPR9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_008663</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the galactose-3-O-sulfotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000239">
        <property type="protein sequence ID" value="RUS83557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TPR9"/>
    <dbReference type="OrthoDB" id="514299at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001733">
        <property type="term" value="F:galactosylceramide sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009729">
        <property type="entry name" value="Gal-3-0_sulfotransfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14647">
        <property type="entry name" value="GALACTOSE-3-O-SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14647:SF87">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06990">
        <property type="entry name" value="Gal-3-0_sulfotr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS83557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="470" mass="55261" checksum="67B14249DEEFB871" modified="2019-05-08" version="1">MQSDTASFLLVAKASKNTRKRQQGSKRVAVWAEKTLCRSSANTCKRLDAAPTNTESSQGKKMYPNLLVNMRRGRIKTLLIIMSMFFILYFCSTTLMERFQASSQRKRPPIPRYGPEIRQVVFAKVHKAASSTMQNILMRFALARNLDVVLPKQGISLSEDGSNINRGSIVPHSQSKQFYDILCNHVLYNEEEISKHFSKSAVRIAIVRDPVDQAVSALKFYYTVWDRTGALTKGFNKHKEDPINSFLRNPQDFYEESFGPAASYINNRMSVDLGFPLTNFQESKKNNTMIREFLEQVERQFDVVLISDYFDESLILMRRILRWPMKNIVYLKVNVGENQTNSVWHKKPTLNSTIIERFREWDKIDFQLYTHFFNIFLERIRIEPLFMEEVEAFRKIQFDLNYFCRNQSTEQVLRITKSEWTPSFTILKRECDLMSISELKLTHVVRLRQTARYEEYVRRNNATRLRARKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TV83</accession>
    <name>A0A433TV83_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mos1 transposase HTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_006785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000169">
        <property type="protein sequence ID" value="RUS85452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TV83"/>
    <dbReference type="STRING" id="188477.A0A433TV83"/>
    <dbReference type="OrthoDB" id="6767820at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001888">
        <property type="entry name" value="Transposase_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF1">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01359">
        <property type="entry name" value="Transposase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS85452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="22200" checksum="0BA5546B965E0961" modified="2019-05-08" version="1">MVEVYAEKCPNYSTVTHWVRKFKSGFLSVMDEPREGRPTSVVTEKNVSTVEGLVKQDRRITVKQLKSETRISVGSVEKILHDHLNLNKVSARWVPRLLTADQKKERDDCCKHLLRLEANDDLFFQKIVTMDETWIYQFDPEPKNASMQWKRPSSPPPKKAKVTQSSGKVMLSCFWDWSEGEGPLMLAPYCRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TVU4</accession>
    <name>A0A433TVU4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_006576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000162">
        <property type="protein sequence ID" value="RUS85700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TVU4"/>
    <dbReference type="STRING" id="188477.A0A433TVU4"/>
    <dbReference type="OrthoDB" id="10041151at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS85700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="184" mass="20910" checksum="A2CB3EE935913198" modified="2019-05-08" version="1" fragment="single">MNIARNKFAQLNTPGQLVSFHKIGNVIMGVKFDEYLTAPMEVVTSEGDDVHNISGSLSENSTWDNYQMVYPTASEDANEELLAWEPHDDDLEFDDDFQLARQRSRSIVTDVLKNGQQRGTKLKFTKQGVPCEDSDSDLEDFHYILDQSELQLKLVDQSLRKKRRDPMGTGLHPNPGKYVCASRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TZ63</accession>
    <name>A0A433TZ63_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylinositol glycan anchor biosynthesis class U protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_005396</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000126">
        <property type="protein sequence ID" value="RUS86859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TZ63"/>
    <dbReference type="STRING" id="188477.A0A433TZ63"/>
    <dbReference type="OrthoDB" id="549017at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009600">
        <property type="entry name" value="PIG-U"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN ANCHOR BIOSYNTHESIS CLASS U PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06728">
        <property type="entry name" value="PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="389"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS86859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="49828" checksum="FD4CD6738003C270" modified="2019-05-08" version="1">MASAGVYIIGLLGVIVRVILMNSYLPKWLQTRNEVVTPITSWNNVEEGFSLQDQLVSPYSGDLFHETPLALRGLRIAHYFPYGVSGFFMFIDVLTMVFLYKIAAPFAKYLLCNQEEEKKNYSTKADSLVLTGNYLSWLPIMVVAMHALNPFSIMTTLAASTAALTNLAVLIAFYNMVIDNRLLSTLFIAVASYQSLYPIVFIVPAALHFYKNSCKSSPVSYTSKDSVCSFAETLSIFGMFLGLLIGFSFLAEKSWDFLFSTYGFILSVPDLTPNIGVFWYFFTEMFEHFRTLFVCVFQLNAVAYTFPLAIKFTEKPFFLLYVLIFLTSIFKSYPSYGDTALYFSLLPLWSHVFPYMRNTLVVGGMYICSVILAPILYHLWIFAGSANANFYFAITLVYSTAQIFLVTDVIFAYLRREFDLYHGTEHVNPDGTKARIKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U0T5</accession>
    <name>A0A433U0T5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VDE lipocalin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_004849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000112">
        <property type="protein sequence ID" value="RUS87395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U0T5"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019166873" description="VDE lipocalin domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS87395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="12779" checksum="97FFC0D8E3663B52" modified="2019-05-08" version="1">MNTFTATLAVVAMLVFSTSATPCSDICAAECALSLQACQFSGALGDLCATENTICTKDCDASCFCVDSCAEKCGTAFAACKGDGVDLLKLESCTFNFEACEAQCGTQCEMQAYNDALKAVIPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U0V8</accession>
    <name>A0A433U0V8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_004797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000111">
        <property type="protein sequence ID" value="RUS87422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U0V8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS87422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="253" mass="28531" checksum="7291943952B44738" modified="2019-05-08" version="1">MKTNLVQEVKGLVIRMESESKALFTMDGCLRVIDSKVQTLERARRGSLSQSPRRRSPSHGNVFFGRGATNHFCSGCFYKPFIPFQYRGGFEYVDQGYSLVMCQNFTFSIYYSCKSTVTCVEGCLPVSISSFLSSYHYLLGIMVGDEDDRCRPKIKGQVSIISVKCMGSREVMAGIMRRGDEDDRFRPKIKGEASIFSGKCLGSREVMAEVRVGDKDGRDRSKLVEVIPKQVDSSNIFRGLENDDGRCRPKLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U229</accession>
    <name>A0A433U229_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ribosomal protein S6 kinase</fullName>
            <ecNumber evidence="10">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EGW08_004359</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">EC2010</strain>
            <tissue evidence="17">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="10"/>
    <dbReference type="EMBL" id="RQTK01000098">
        <property type="protein sequence ID" value="RUS87881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U229"/>
    <dbReference type="STRING" id="188477.A0A433U229"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05584">
        <property type="entry name" value="STKc_p70S6K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000092">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000686">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016238">
        <property type="entry name" value="Ribosomal_S6_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000605">
        <property type="entry name" value="Ribsml_S6_kin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="71"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="16">
        <location>
            <begin position="337"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="504"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="512"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="77"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 13">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000605-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000605-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RUS87881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="526" mass="57936" checksum="B5C82B0AF3896EE1" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U3L9</accession>
    <name>A0A433U3L9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_003774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000082">
        <property type="protein sequence ID" value="RUS88437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U3L9"/>
    <dbReference type="STRING" id="188477.A0A433U3L9"/>
    <dbReference type="OrthoDB" id="6141955at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF110">
        <property type="entry name" value="RHODANESE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="77"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS88437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="227" mass="26069" checksum="158F29F7173E7F50" modified="2019-05-08" version="1">MSSNTSAKNFRDSEQVEQKIFRRDITYQEVQEQYDDWADYYDQTLDGKPKVYNTLMAYEEGMDTLFDATEKPNRRCLDLGAGTGLTGERLLKVGYTNIDGLEPNEKMADVCKKKGIFREFYVQPIGGDNPLKTPDNSYDAICCAGSFAPGHIPCSAIPEIVRLLKPGGYFLNCMREEFIHDVPEYKDRLVPMFNDLEKQGLIKTVEWTVYPNHYIDKPGVRMVYQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U464</accession>
    <name>A0A433U464_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_003619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000078">
        <property type="protein sequence ID" value="RUS88593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U464"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS88593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="136" mass="15216" checksum="661E20E1BA123EDA" modified="2019-05-08" version="1">MDSYINVVTLLLMFIVLHELYCVCCIKTFEVAFNLAFHFPNFNGKIQLSYFMTMSSVGQNWVAELTKVHHLGLGVNNGLVQHLESIVQICFGPVGRPKNLQVKRPTTGSFHVVVSPYSSKLATHLALNYSSLSLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U4I2</accession>
    <name>A0A433U4I2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_003529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000075">
        <property type="protein sequence ID" value="RUS88714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U4I2"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS88714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="102" mass="10520" checksum="A10AC1BBFF6121A0" modified="2019-05-08" version="1">MAEHGVIVIMAEHGVIVIIAEHGVIVIIVEHGVIVITAGHVVIVIIAEHGVIVIRAGHGVIVIIVGHGVIVIIVGHGVIVIIAEHGVIATSDWDSPETAVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U7M4</accession>
    <name>A0A433U7M4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_002371</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000046">
        <property type="protein sequence ID" value="RUS89841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U7M4"/>
    <dbReference type="STRING" id="188477.A0A433U7M4"/>
    <dbReference type="OrthoDB" id="295656at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000130">
        <property type="entry name" value="COP9 signalosome complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041406">
        <property type="entry name" value="CSN4_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF2">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18420">
        <property type="entry name" value="CSN4_RPN5_eIF3a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="188"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS89841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="396" mass="44950" checksum="6B9CCD9038E95BEB" modified="2019-05-08" version="1">MSLSHSSGSHKDVTERYKTILEGVIKTGGAELVPSLQAFIEALVSEGVSLVISRQILTDFTAQLSRMPDGVAKEVSHYTLEKIQARVISFEEQVAAIRQHLANIYEREESWREAANVLVGIPLETGQKQYSPDYKLETYLKIARLFLEDEDANQADAYINRASLLQAESKNEELQIVYKACYARVLDFRRKFIEAAQRYNELSYKSVVSKEERLTALKNALICTVLASAGQQRSRMLATLFKDERCQQLPAYNILEKMYLDRIIRSSDLVDFSALLLPHQKAITPDGSTILNRAVTEHNLLSASKLYNNISFAELGSLLEIPPQKAEKIASQMITEERMNGYVDQIDSIVHFEARETLPMWDRQIQSLCFQVNTIIEKISAAEPEWFTKAMEQNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UA47</accession>
    <name>A0A433UA47_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_001508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000026">
        <property type="protein sequence ID" value="RUS90704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UA47"/>
    <dbReference type="OrthoDB" id="6159161at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS90704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="217" mass="25679" checksum="33C4DF7AF00460B6" modified="2019-05-08" version="1">MTCTGESPREDGVPTALLTTKNKAKIGTWNTRTLYETGRTAQLSTKLKTFNDNAGRPEHKYNVQCLIEKQKSEHFKIELRNKFSVLSLLPEETIEEQWLSLRETWKETCSTVLGKKIRKHMEWISTDTWTRITERKNLKHQINQPQGIEEKHTLQARYWEKNREVTKSARKDKRNYIEELTTEAEAVESERNMERLCNHQDSLGEEQKLQLPRQRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UC34</accession>
    <name>A0A433UC34_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_000936</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000014">
        <property type="protein sequence ID" value="RUS91322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UC34"/>
    <dbReference type="STRING" id="188477.A0A433UC34"/>
    <dbReference type="OrthoDB" id="6147673at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019343173" description="Peptidase S1 domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS91322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="53457" checksum="78B72F3F9B1591A7" modified="2019-05-08" version="1">MYQHHTFLVGCLLIIHSVPLDARFSRFNAPHGQRQRVDPHWQKVDTQRQRVDNQLNECRSHHELYDYKPCPKESCNENGASLGKCCLEVSQNFHGDVKTKECRCDSRSGCPQDNVKQSRQSQSKKPASSSQTKQKVPPAKPTTVTIKPEASQRNCTFDFEIQSYKTCSMEFCDSSSQSDNALCCKHRQSLSIPETCLCHPQITCDLPKVSTPDDIVEAGVTEADVTEPVVTEAVVTEAAVAVDEPSLCENRFRLLNADRVTNPCKYNGVAKLTRKDANGDALICNAVYTIAKVKGTIRHTFLTPQACGLLIEQLSKDMSLELQVGDQIYPVQEPIFTTESGPNGNWYIGIGSRYINLFRDLGACQKKACPYDAIGMRGKVDFNDCKAVSYGASDAANFTTDGLYETSIALYPGGCLEQDDFFGVKSTLCFRTIDAENAYCANDAGGPVYCKSPSTNEWILLGILAFQNKCDTQAELKVIPFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z643</accession>
    <name>A0A3S0Z643_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_022089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001480">
        <property type="protein sequence ID" value="RUS70148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z643"/>
    <dbReference type="OrthoDB" id="6019893at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051696">
        <property type="entry name" value="DENN_Domain_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296:SF21">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="1">
        <location>
            <begin position="109"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS70148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="494" mass="55348" checksum="8F7D4C78B072EBCE" modified="2019-04-10" version="1" fragment="single">MGDKQTDAARPMHFNLYNRFAELMLVVGLDENTGLTRFHKGANAEEEEDAEEDSLSLLFFQQYEAQVLAAISSSKALVFQPHLMEDPSYPSRPDIANGGTHNFQDLRKSRLAKGSGSRRQVQAVNAAVIKQHLNKGDSSKSMPDLPLSKDAIESITTFCFPDNAHIYRHKPDSNIHFLVLTDVSGSKTYASCLTFYKPYRLTKDSGGTIQFELLTNPSWKQESRSSVDCFIPQCCVLVSKYPYFYAMKECLSCMISHVERDLEEMYQFIKDFTYTMTMAPVPPAGNVIVEMSVYNLSVSLFPSESPEKPVIDLPLHLAFLCFPVDDLLSIFTAILCEERLVFVSFNYALLTTIMESFLYYILPMTWRFTYVPILSASSLELLEAPGTFMMGCHSKHLDVVEQVEGLVVVNIDEGTVNINPVTSSAMGGYHHHSLTMSTASSLTSSISSGIHERSEMVVIDQTTQAIPSLPEEPAKLFKNICKRAKFQMELSDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZC57</accession>
    <name>A0A3S0ZC57_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_020668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001193">
        <property type="protein sequence ID" value="RUS71575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZC57"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS71575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="107" mass="12047" checksum="E7FCD360A73237DD" modified="2019-04-10" version="1">MLSKLYFSLSSLGLSFPSLYSALLYVPLNLLSHCPATPQPTPRTPPLLSLSLLLGLSLHFRSLLNTGMSFFIPLFSIFRFYPPLLPLSLSLRFFCFFFGLSLFSYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZD74</accession>
    <name>A0A3S0ZD74_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_017212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000777">
        <property type="protein sequence ID" value="RUS75031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S0ZD74"/>
    <dbReference type="OrthoDB" id="166212at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS75031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="216" mass="23773" checksum="4ABD63C5B58BE3F3" modified="2019-04-10" version="1" fragment="single">MFLDNEEAIVYKYYGQNRLITRDVNRTPWLHVVKSGHVKVVRRQSVVDVTDNSTRFQARTTDELGCGRSFSHAKAMLGNLTSQRQMKKLSEISLPEXXXRRSTILIEEGMRGNRKRRPTLKLTTPVIREMSGPKPGEAEVADPTSSPASGHKTKKDLTLPPIVVTSEEPPTESRSQSGKRKGSGQAGERRGSPPKGVSVSMPTSVLSEAVKASGMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZG65</accession>
    <name>A0A3S0ZG65_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Band 7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_014093</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000530">
        <property type="protein sequence ID" value="RUS78145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZG65"/>
    <dbReference type="STRING" id="188477.A0A3S0ZG65"/>
    <dbReference type="OrthoDB" id="2105077at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000002">
        <property type="entry name" value="band 7 protein AGAP004871"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF19">
        <property type="entry name" value="AT06885P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="4">
        <location>
            <begin position="2"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS78145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="144" mass="16071" checksum="CFDCB51C17116E5B" modified="2019-04-10" version="1" fragment="single">CYLFQVVQEYERAVIFRLGRLLSGGAKGPGLFFIIPCMDSYTKVDLRTVSFDVPPQEVLTRDSVTVAVDAVVYYRVQNATMSITNVEDANRSTRLLAATTLRNVLGTKNLSEILSDRENISHVMQSALDEATDPWGVKVERVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZGE6</accession>
    <name>A0A3S0ZGE6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_017982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000851">
        <property type="protein sequence ID" value="RUS74244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZGE6"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS74244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="110" mass="12219" checksum="625099928706A845" modified="2019-04-10" version="1">MHSAGFEHMYGQRWVNTFVLGSQASALSSDQYTTHCLFFFLFTLCSLSVSLTFSLSLSHSLSLSLSLSTLSLSLSLSMFDGLIFLLNIGKGNLSHRSFKLQPIFKKTADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZI24</accession>
    <name>A0A3S0ZI24_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_013999</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000524">
        <property type="protein sequence ID" value="RUS78230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZI24"/>
    <dbReference type="STRING" id="188477.A0A3S0ZI24"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS78230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="262" mass="29015" checksum="8D68B01DC5EE7AB4" modified="2019-04-10" version="1">MGDHRSTTFASSFPTAPEVLAQQPYGKEVDCWSIGVIAYILLCGYPPFYDENDAELFKQILKAQYEFDSPFWDEISESAKDFIRHLMCKDPKDRFTCKGAIAHPWISGNAALDKNIHASVKAQMLKTFARNKWKPQCSKVIFLFVIPPPPLLAAKDFIRHLMCKDPKDRFTCKGAIAHPWISGNAALDKNIHASVKAQMLKTFARNKWKQAYNATAVIRQMKKLVVVNKEEGGGGGGSSNHTDGASSSHQPSPEAKAGSSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZJH8</accession>
    <name>A0A3S0ZJH8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_023366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001956">
        <property type="protein sequence ID" value="RUS68874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZJH8"/>
    <dbReference type="STRING" id="188477.A0A3S0ZJH8"/>
    <dbReference type="OrthoDB" id="411211at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045453">
        <property type="term" value="P:bone resorption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051558">
        <property type="entry name" value="Metallophosphoesterase_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10161">
        <property type="entry name" value="TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10161:SF14">
        <property type="entry name" value="TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS68874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="14002" checksum="E8057801FF0DEB32" modified="2019-04-10" version="1" fragment="single">RANYLFTAGHFPIYSVGAHGPTECLTKDLQPMLETFEANGHFCGHDHNLQHLMVHTNQGQRIDYFVSGMANFVNPSTKHKGDVPDGSLQFHNANYFTKGGFLYAEATPQNMTFTFIAASGQVLYTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZJM7</accession>
    <name>A0A3S0ZJM7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_011767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000390">
        <property type="protein sequence ID" value="RUS80451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZJM7"/>
    <dbReference type="STRING" id="188477.A0A3S0ZJM7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS80451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="204" mass="24035" checksum="259171936D045DAB" modified="2019-04-10" version="1" fragment="single">MQVDLLYLQVDLLYLQVDLLYLQVDLLYLQVDLLYLQVDLLYLQVDLLYLQVDLLYLQVDLLYLQVDLLYLQVDLLYLQVDLLYLQVDLLYLQVDLLYLQVDLLYLQVDLLYLQVDLLYLQLEARMHVPKRYIPGLEGRTSVPKRYIPGLEGRTSVPKRYIPGLEGRTSVPKRYIPGLEGRTSVPKRYIPGLEGRTNVPKRYIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZJS2</accession>
    <name>A0A3S0ZJS2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_015842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000666">
        <property type="protein sequence ID" value="RUS76391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZJS2"/>
    <dbReference type="OrthoDB" id="6148366at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS76391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="278" mass="32096" checksum="FBBAF559B5BC6C98" modified="2019-04-10" version="1">MAEGFDIDLHPQRMVNITVSQFELDSLYEAHAKTCIQLKAFKSDYSILKTKFDEAQAQLGEANTQLDNKNVKVAQLIQQLAQQIVRNFFLQRRLLNGRGVEKNDGATQTWPESILAVQEAREPAQEDTMNSEYVCPRKNDSTEAALKDKLFKIEALYDIIQRENESMARQMAKLSSKLRILSMQNEDLDQYLGTTIRKQGRFEIRKWLECDQCYRGFSSHEEMKRSVCHFHPMQAVPYDDMNGKKYYYLCCSGLVKNKGQASGCCKGKHRLSIKQNRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZKS7</accession>
    <name>A0A3S0ZKS7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CG-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_012178</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000413">
        <property type="protein sequence ID" value="RUS80061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S0ZKS7"/>
    <dbReference type="OrthoDB" id="407555at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005559">
        <property type="entry name" value="CG-1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23335">
        <property type="entry name" value="CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR CAMTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23335:SF1">
        <property type="entry name" value="CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03859">
        <property type="entry name" value="CG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01076">
        <property type="entry name" value="CG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51437">
        <property type="entry name" value="CG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="CG-1" evidence="5">
        <location>
            <begin position="32"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="232"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="429"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="636"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="814"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="944"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1046"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1082"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1460"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1641"/>
            <end position="1685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1727"/>
            <end position="1769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2001"/>
            <end position="2051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2065"/>
            <end position="2145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="429"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="470"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="639"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="827"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="950"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1082"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1465"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1535"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1564"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1749"/>
            <end position="1760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2024"/>
            <end position="2046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2092"/>
            <end position="2105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2107"/>
            <end position="2116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2124"/>
            <end position="2143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS80061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="2188" mass="235558" checksum="C6C5A9767F5BC642" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZMI8</accession>
    <name>A0A3S0ZMI8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_013792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000509">
        <property type="protein sequence ID" value="RUS78446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZMI8"/>
    <dbReference type="OrthoDB" id="6147983at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF67">
        <property type="entry name" value="COREPRESSOR OF PANGOLIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="1">
        <location>
            <begin position="207"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS78446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="383" mass="43865" checksum="34DE8A130ADEECBC" modified="2019-04-10" version="1">MATPKVEANASPVSPLSVGETFNTYAEAELRIHQWGEQNHTLFIKTDGKRVKHEDLQHTVGYEYISYACKQGGPPRVGSGRGIRVNQRTLKTNCPVKLRLVHEIIEGEHKLVIKTLILDHNHEISELIYKGYPENRRASITPELVDLLNSPEVSNTVVRDFIKQEQGVLMLPRDVNNLRKRVHSEAFPKSEDSEYKISDAEKEFCTQLIQEIQTHSCLYDPAEKNNKGAIEITWGQVAQTMNTSVAHARRKWSELKNAFCKYLNPNKVFQKPKNFPFLEDMAFLQPYLSVSESSEYRTPRVTSYPVQYTSNAGGRYISSGMIHQPPEDSDVSWFKGLLPLIKCLTKKRKRQFISETTNLLMTLADENDNEEDEKTSTIYIFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZSA3</accession>
    <name>A0A3S0ZSA3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Spindle and centriole-associated protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Coiled-coil domain-containing protein 52</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_006625</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000164">
        <property type="protein sequence ID" value="RUS85613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="188477.A0A3S0ZSA3"/>
    <dbReference type="OrthoDB" id="6361178at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051310">
        <property type="term" value="P:metaphase chromosome alignment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046599">
        <property type="term" value="P:regulation of centriole replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031387">
        <property type="entry name" value="SPICE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31167">
        <property type="entry name" value="SPINDLE AND CENTRIOLE ASSOCIATED PROTEIN 1 SPICE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31167:SF3">
        <property type="entry name" value="SPINDLE AND CENTRIOLE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15678">
        <property type="entry name" value="SPICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="155"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
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            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
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            <end position="351"/>
        </location>
    </feature>
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        <location>
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            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="616"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
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            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="780"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="744"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="218"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="341"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="506"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="516"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="629"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="662"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="682"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="781"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS85613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="866" mass="96207" checksum="561EFA55157F6028" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZTC6</accession>
    <name>A0A3S0ZTC6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SUZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_006854</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000172">
        <property type="protein sequence ID" value="RUS85369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZTC6"/>
    <dbReference type="STRING" id="188477.A0A3S0ZTC6"/>
    <dbReference type="OrthoDB" id="278430at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02642">
        <property type="entry name" value="R3H_encore_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051937">
        <property type="entry name" value="R3H_domain_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024771">
        <property type="entry name" value="SUZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15672">
        <property type="entry name" value="CAMP-REGULATED PHOSPHOPROTEIN 21 RELATED R3H DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15672:SF8">
        <property type="entry name" value="PROTEIN ENCORE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12752">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51673">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="3">
        <location>
            <begin position="8"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="SUZ" evidence="4">
        <location>
            <begin position="70"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
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            <end position="202"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
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        </location>
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            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="323"/>
            <end position="336"/>
        </location>
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        <location>
            <begin position="640"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="698"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="796"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="813"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="845"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="950"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1015"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS85369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1015" mass="109325" checksum="94A49453F3BACCF5" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZVZ0</accession>
    <name>A0A3S0ZVZ0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_004123</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000093">
        <property type="protein sequence ID" value="RUS88070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZVZ0"/>
    <dbReference type="STRING" id="188477.A0A3S0ZVZ0"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS88070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="318" mass="39443" checksum="1662C284BFF87CFC" modified="2019-04-10" version="1" fragment="single">FYDLYIDLYLSVIYTFIHHHKDLDLYLSMIYTFIHHHTYIDLYLSVIYTFIHHDKNLDIYLSVMYTFIHHHKNLDIYLSMIYTFIHHHTDLDLYLSVIYIFIHHHSDIDIYFSVMYTFIHHHKNLDIYLSVIYTFIRNHKDLDIYLSVIFTFIYHYTDIDIYLSVIYTFIHHHTYIDIYLSMIYTFIHYDKNLDIYPSVMYTFIHHHKNLDIYLSMIYTFIHHHTDISIHLSVIYTFIHHHTDIDLYLSVIYTFIHHHKDIDIYLSMIYIFIHRHKNLDIYLSMIYTFIHHHKDIDIYLSMIYTFIHLSLYDLYIYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZYQ6</accession>
    <name>A0A3S0ZYQ6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_002834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000057">
        <property type="protein sequence ID" value="RUS89397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZYQ6"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS89397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="494" mass="53151" checksum="36F0D46A32306DBC" modified="2019-04-10" version="1">MYALFVCSLHLLDEPVGTCPPLPGNLGHDLQETSHDQAKPSSLKRNSKQQQENQDRAVPQDASTESVQSNDARNSKSASLTSGISENRARDVRPSGGSKSSKDNSHRQLVKEQRPKQSYGALEDSTSDSGKSAGGVSGKAGSRRDSNFRCDAGSEGRGISVDPDTAYVVSRNTVVHGGAHSGDDADSDDIDDEAVFLPCDDTLGASDGAVSSGLSYAGSSGGINSRADCSSNRNPEVYRAPQHYADDNDNDDDVENEINENVALVSAKQCKDKTSTLSSPSSSSTAASLSNKGDKNKADKNGAYTLEDAEKPQTSRKNFARLIGLYRRDINKSGKSARLSGTTSDCQPDTGRKASGGTPTQVNQVTSPKSPRTPTIQDHNSITQLKTFTDPVRHHRLRACAQIFTRKDPLYHPDQVEQQHLLPQQPAAAAATKSTTTTTPKHQLPNTAKHKVSFITGLRRFSREKAAFLRVDHSEPKASKTRPIPQPRRSCSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZZ12</accession>
    <name>A0A3S0ZZ12_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_005675</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000135">
        <property type="protein sequence ID" value="RUS86536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S0ZZ12"/>
    <dbReference type="OrthoDB" id="6217760at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000167">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117:SF6">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF16B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="1"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="845"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="995"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1207"/>
            <end position="1688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1965"/>
            <end position="1994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2023"/>
            <end position="2064"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="569"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="753"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="879"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="895"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="942"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1010"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1021"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1087"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1113"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1141"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1272"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1289"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1340"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1385"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1397"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1416"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1429"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1460"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1482"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1520"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1542"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1578"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1629"/>
            <end position="1642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1645"/>
            <end position="1663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1667"/>
            <end position="1677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1679"/>
            <end position="1688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2036"/>
            <end position="2047"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS86536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="2078" mass="233925" checksum="CF91F23EF7FE215C" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A0E1</accession>
    <name>A0A3S1A0E1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_001599</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the copine family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000028">
        <property type="protein sequence ID" value="RUS90602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A0E1"/>
    <dbReference type="STRING" id="188477.A0A3S1A0E1"/>
    <dbReference type="OrthoDB" id="5855668at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04048">
        <property type="entry name" value="C2A_Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04047">
        <property type="entry name" value="C2B_Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01459">
        <property type="entry name" value="vWA_copine_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000099">
        <property type="entry name" value="Copine 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000013">
        <property type="entry name" value="copine-9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037768">
        <property type="entry name" value="C2B_Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045052">
        <property type="entry name" value="Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010734">
        <property type="entry name" value="Copine_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857:SF106">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857">
        <property type="entry name" value="COPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07002">
        <property type="entry name" value="Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="C2" evidence="6">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="6">
        <location>
            <begin position="130"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="7">
        <location>
            <begin position="296"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="533"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS90602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="574" mass="64265" checksum="4B0D80B84513532A" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A3Y1</accession>
    <name>A0A3S1A3Y1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_002204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000042">
        <property type="protein sequence ID" value="RUS90017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A3Y1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS90017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="157" mass="18246" checksum="B7B44CB32FB5CFD8" modified="2019-04-10" version="1">MPLCSAAAGANFRERGRFPASYHYHYQRPLDTGRVVSHYHYQRPVDTGPVVSHYHYQRPVDTGPVVSHYHYQRPVDTGPVVSHYHYQRPVDTGPVVSHYHYQRPVDTGPVVSHYHYHYQRPVDTGPVVSHYHYQRPVDTGPVVSHYHYQRPVDTGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A4L3</accession>
    <name>A0A3S1A4L3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_009609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000278">
        <property type="protein sequence ID" value="RUS82616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A4L3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS82616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="145" mass="15795" checksum="3E3169738306D12C" modified="2019-04-10" version="1" fragment="single">KDDSHATRGWPTHALHHDGQDWFVQHVCQPQLSVAQVGRCVLRPPEALVYLGGELVPAAHLTDVHPAGVAGALQVVPERHDLVLHVPLVAEEDLRPLQVVLWGGRDTRQANDISDVVAAKMLQVVQQNVHGHGCVARGHDPVCQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A6W1</accession>
    <name>A0A3S1A6W1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">FAM69 protein-kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_008046</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DIPK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000214">
        <property type="protein sequence ID" value="RUS84206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A6W1"/>
    <dbReference type="OrthoDB" id="8543887at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022049">
        <property type="entry name" value="FAM69_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029244">
        <property type="entry name" value="FAM69_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21093:SF2">
        <property type="entry name" value="DIVERGENT PROTEIN KINASE DOMAIN 1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21093">
        <property type="entry name" value="DIVERGENT PROTEIN KINASE DOMAIN 1C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12260">
        <property type="entry name" value="PIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14875">
        <property type="entry name" value="PIP49_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAM69 N-terminal" evidence="10">
        <location>
            <begin position="10"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="FAM69 protein-kinase" evidence="9">
        <location>
            <begin position="160"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS84206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="43938" checksum="99323E3CEA96BF40" modified="2019-04-10" version="1" fragment="single">TLYGGTGSKCKLYERKEIIGNLCKPLCHKQNIQFSQCLNYKKGKHVISVQCKDHCVPGKTVPAVLKMARLNGEPLDKHLAEAGKELLIKTKPNVDPNTVSVFEYFISSESLSLLTSDYLNEEYGYFAREDQDLLSVIWGEDYPEKFRGPNTNLVFARSYWALLRQNEFRISRVFGEWEVFPNIYDFCGPLYMAEHSPPFKSLDTLFPFLHTEFPPWANRAKLAIQILELVQRMDTMEHPLHLCDTKSPHFGFTPSGQVRFIDSDTVFADEALSRIMSSQVCGSDAECIFYDCEGVCNKQTGKCLEMRSNNNLQVVCSKVFRGTTFAAYGGLLSTPPKSVAAKLTALVTECATDTKADLSGVVSRKPSQDTLLKLQRYLLESLKQEAAAEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AA87</accession>
    <name>A0A3S1AA87_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CARD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_005627</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000133">
        <property type="protein sequence ID" value="RUS86611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AA87"/>
    <dbReference type="OrthoDB" id="6142498at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01671">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50209">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CARD" evidence="2">
        <location>
            <begin position="8"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS86611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="247" mass="28213" checksum="6278CBDF37E5BA1A" modified="2019-04-10" version="1">MDVLGLKYRQHREEVTHALAVSTELLTLLTREGLLDIADCVKYQGITNSKRRTAALMKTLTERRTDRAYPVLLQCLRETGQHRAVDLLTDVGEEAHAIQELQIKLDEQVTAIDEFLEVEERRAGLAQDKLDCGHEDKRTRPSPPATSDRQVWTDAQDSMRRAVDALSRCQAVIAKLHQDCLQVAHTNAELTAETRSCYLQVRHTFFRRDTLPSVETSYLHMRHVTSRRGRLPPGEAGYLQLRQVTFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1ABZ9</accession>
    <name>A0A3S1ABZ9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Saposin B-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_004302</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000096">
        <property type="protein sequence ID" value="RUS87947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1ABZ9"/>
    <dbReference type="STRING" id="188477.A0A3S1ABZ9"/>
    <dbReference type="OrthoDB" id="14839at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050528">
        <property type="term" value="F:acyloxyacyl hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009104">
        <property type="term" value="P:lipopolysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.210">
        <property type="entry name" value="Ribonuclease P/MRP, subunit p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039676">
        <property type="entry name" value="AOAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048593">
        <property type="entry name" value="AOAH_Saposin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036980">
        <property type="entry name" value="RNase_P/MRP_Rpp29_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023534">
        <property type="entry name" value="Rof/RNase_P-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002730">
        <property type="entry name" value="Rpp29/RNP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15010">
        <property type="entry name" value="ACYLOXYACYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15010:SF0">
        <property type="entry name" value="ACYLOXYACYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01868">
        <property type="entry name" value="RNase_P-MRP_p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20825">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00538">
        <property type="entry name" value="POP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00741">
        <property type="entry name" value="SapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101744">
        <property type="entry name" value="Rof/RNase P subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Saposin B-type" evidence="3">
        <location>
            <begin position="196"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS87947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="735" mass="83714" checksum="D56ED2AF42E46107" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AH85</accession>
    <name>A0A3S1AH85_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleoplasmin core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_000114</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoplasmin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000002">
        <property type="protein sequence ID" value="RUS92090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AH85"/>
    <dbReference type="STRING" id="188477.A0A3S1AH85"/>
    <dbReference type="OrthoDB" id="6075101at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.340">
        <property type="entry name" value="Nucleoplasmin core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004301">
        <property type="entry name" value="Nucleoplasmin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024057">
        <property type="entry name" value="Nucleoplasmin_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036824">
        <property type="entry name" value="Nucleoplasmin_core_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22747:SF18">
        <property type="entry name" value="GEO09167P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22747">
        <property type="entry name" value="NUCLEOPLASMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03066">
        <property type="entry name" value="Nucleoplasmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69203">
        <property type="entry name" value="Nucleoplasmin-like core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoplasmin core" evidence="5">
        <location>
            <begin position="36"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="150"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="221"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS92090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="285" mass="32055" checksum="F46888A952F255E9" modified="2019-04-10" version="1">MASRNRRQSDKSNNSKMDESVKSSGYAAGLTEMEYFWSIELNDSNRTHTWMNNDDMEDGDEDFIEYTVFLKSATLGANAVPNERNLVMLESAGSDGEPQKGCIVHLCLGQNNMTPLDITVSGKVGPTTFTLAEGSGPVYICGNQLLEFPKEDSFLDNSQTESEKEETEEEDDDEEEEDDAEMEEDGKKVEKTDADAKKQPMKRKAAPIVGKPKQKPKVDKEEEEEDIEDDDEEEEEEEEEEEEEESEEDSEEEVKLKKAKKGKETGKKESKAKAVVKKPAKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AQC6</accession>
    <name>A0A3S1AQC6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_023238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001878">
        <property type="protein sequence ID" value="RUS68999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AQC6"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.150.10.10">
        <property type="entry name" value="Serralysin-like metalloprotease, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69349">
        <property type="entry name" value="Phage fibre proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS68999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="103" mass="11331" checksum="605C466A2991F1B4" modified="2019-04-10" version="1" fragment="single">DHENTTLLGHVNTTFDINNTILLGQDNTIFFGHDNTILLGYVNTMFGHNNTNLLGHNNTTLLDYNNTTLLGHNNTILLGHKNTTLLGHDNTSLLGHNNTSHDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AQU9</accession>
    <name>A0A3S1AQU9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Cytochrome b-c1 complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Complex III subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_022739</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12 13">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with UQCC6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the UQCRQ/QCR8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001663">
        <property type="protein sequence ID" value="RUS69499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AQU9"/>
    <dbReference type="STRING" id="188477.A0A3S1AQU9"/>
    <dbReference type="OrthoDB" id="6683853at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.210:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.210">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004205">
        <property type="entry name" value="Cyt_bc1_su8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036642">
        <property type="entry name" value="Cyt_bc1_su8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12119:SF2">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12119">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX UBIQUINONE-BINDING PROTEIN QP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02939">
        <property type="entry name" value="UcrQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81508">
        <property type="entry name" value="Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS69499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="83" mass="9725" checksum="DA61F6FFD057CB9B" modified="2019-04-10" version="1">MGMKWGNMATNVRGLVMYSLSPYEQKAFAGAFSKGIPNMFRRFRGQVFRVVPPFIGGYLIYSWAQEEHERLMRKDPKEFLNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1ASE2</accession>
    <name>A0A3S1ASE2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_021470</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001338">
        <property type="protein sequence ID" value="RUS70768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1ASE2"/>
    <dbReference type="OrthoDB" id="6158390at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS70768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="509" mass="56762" checksum="01D0759248383220" modified="2019-04-10" version="1">MRDLFQAAGHGRPTSVDSFRACAWLLLLALCGVTWLLPLSPAVNTLESNPRPLFSVPKVKDKEKVNTTVTDGIVEKALKAARCDTGYDSFGQDCELLKDTLGQLNKHLLDQGQKEDAGDREEDEGIPWNQDPDILPDLTVNCWCPAQFEPAQVAYTNSLCASNINRYIRGLDLEQNSDKDEPHPRGRVDVEADEVTVSGSVAESLRNMTQRKVYRQRKDVFDRYNHFVTRKTSFLLFVFGLVLLAPSLMWWKLAASTWCALNVDTTLDTLRHAQSCEPDVRGRIYQDISRYTSSGHTAKCFLLCKLLVCCASLVALVSVSQLLHVQANTLAGELEELSDMAKLAPLEDQGLLFHCFFTIRMMQNQHDYTVQCSTSFSDHGRVESARQNGMGPHHQLDWARRGVLAYGTLFQIVAAFLIMHATFNLCGFLEWVRRIYVDTNRFQSGTQNSDSDRPSGVGFAEDVRFLLHTAHAHLGHVVCKELAVSLAQGRHGSPAAGSGGKPRDAEDNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AVH4</accession>
    <name>A0A3S1AVH4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Roc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_022828</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001692">
        <property type="protein sequence ID" value="RUS69413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AVH4"/>
    <dbReference type="STRING" id="188477.A0A3S1AVH4"/>
    <dbReference type="OrthoDB" id="10252328at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1390">
        <property type="entry name" value="ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020859">
        <property type="entry name" value="ROC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08477">
        <property type="entry name" value="Roc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51424">
        <property type="entry name" value="ROC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Roc" evidence="4">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS69413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="208" mass="23928" checksum="D270756892C2A5C8" modified="2019-04-10" version="1" fragment="single">MNLMFVGFHSIGKTSLLQRLCERGRTLQKSSHWRDRVNKEEGKKQTTLLSTVGIDINELLLEKRSKGPVVFRTWDFGGQKEYYATHQYFLSPRSLYLVVWSIIDGERGVESLLQWLINIQARAPGAPVIIVGTHLDILRDRATRRHYPEDFEESMMLLIQKMFLSNPEPDKSGLPNILAAVNVSCKTGENIRILVDMIYENAFELKHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AVX8</accession>
    <name>A0A3S1AVX8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_022503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001589">
        <property type="protein sequence ID" value="RUS69736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AVX8"/>
    <dbReference type="STRING" id="188477.A0A3S1AVX8"/>
    <dbReference type="OrthoDB" id="6142292at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35385:SF2">
        <property type="entry name" value="PROTEIN B, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35385">
        <property type="entry name" value="PROTEIN B, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS69736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="365" mass="41614" checksum="FD3FAD87E17BE381" modified="2019-04-10" version="1">MKVRTVSTQGLDKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKQRQEKEKQGVGRGGTRSKDIHIHEWLTKVTLLWGHSHPLDDPFVLKYRDVRPATRQRLLEFFSQGYHIHTAHCLLKHELRLAGLEHPLAEVDKAFIPELDYLARLQKHFFMEKLGLHENISALGSIYEILARIKSRAIDEGVKTEATIVEGEVVIAMTTPIMERVHTLAPQSAQFVFVDSIDMIEKNKCIVRLLVTHSPSGALPLGCLLSTSASAQCTEQGLRLLQTILPAGAFYGQGRDGPKVWLTKGWNDGECQALRSVFPQGKQALSSHHMLYTLWSLMYNKHSIAKGTDRLSLLNKLKGMAYNIECFVSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AWY6</accession>
    <name>A0A3S1AWY6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase alpha catalytic subunit N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_022812</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001685">
        <property type="protein sequence ID" value="RUS69431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AWY6"/>
    <dbReference type="STRING" id="188477.A0A3S1AWY6"/>
    <dbReference type="OrthoDB" id="6161030at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024647">
        <property type="entry name" value="DNA_pol_a_cat_su_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861:SF1">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12254">
        <property type="entry name" value="DNA_pol_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha catalytic subunit N-terminal" evidence="2">
        <location>
            <begin position="26"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS69431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="138" mass="15858" checksum="7F8BA1EEB4BB718B" modified="2019-04-10" version="1" fragment="single">DGDTSLAQGRSRRQKVDKKGRLSAFEKLREAKEKGIKNKYEVQEEKNVYDVVEEEEYSDLVRQRQEDDWIVDDDGGYVEDGREIFDDEMDESAPVRPGHKRADGKKKNKNIVRPGTKPKQDIKSMFAAAAVSTKRKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B076</accession>
    <name>A0A3S1B076_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_023579</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01002134">
        <property type="protein sequence ID" value="RUS68659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B076"/>
    <dbReference type="STRING" id="188477.A0A3S1B076"/>
    <dbReference type="OrthoDB" id="6158937at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43023:SF6">
        <property type="entry name" value="INTERMEMBRANE PHOSPHOLIPID TRANSPORT SYSTEM ATP-BINDING PROTEIN MLAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43023">
        <property type="entry name" value="PROTEIN TRIGALACTOSYLDIACYLGLYCEROL 3, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS68659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="218" mass="24183" checksum="18088C74D905D0F7" modified="2019-04-10" version="1" fragment="single">DISFENVSFYREAKCIYNDISFQIPSKKITTILGPSGAGKTTILQLIAGLIKPTTGQICVDEHRVRPNSSEKSLEEMRKKLGFLFQSGALFNQMSVYDNIAFPIRKNTLLDENIIHTIVLLKLEAVGLAYTIDMMPSELSGGMARRVALARSIALDPDIMMYDEPFTGQDPTSFKKLLKLISTLNYTLGITSILVSHNIEESLSLSDHIIIVGDKSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B0T4</accession>
    <name>A0A3S1B0T4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Galactosyltransferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_018834</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000941">
        <property type="protein sequence ID" value="RUS73395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B0T4"/>
    <dbReference type="OrthoDB" id="10016069at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008378">
        <property type="term" value="F:galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00899">
        <property type="entry name" value="b4GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003859">
        <property type="entry name" value="Galactosyl_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027791">
        <property type="entry name" value="Galactosyl_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027995">
        <property type="entry name" value="Galactosyl_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300:SF57">
        <property type="entry name" value="BETA-1,4-N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02709">
        <property type="entry name" value="Glyco_transf_7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13733">
        <property type="entry name" value="Glyco_transf_7N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02050">
        <property type="entry name" value="B14GALTRFASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Galactosyltransferase N-terminal" evidence="12">
        <location>
            <begin position="10"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase C-terminal" evidence="11">
        <location>
            <begin position="129"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS73395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="33821" checksum="6F0E8772AA88782C" modified="2019-04-10" version="1" fragment="single">GGQFATALDPVQLYQVEQKYPEVSDGGHYQPRQCKAREKLAIIIPCRNREHHLYILLYNLLRLLIKQRLDFSIFVIDQEMPTTFNRGMLFNVGYLEALKVRDFDCFILHDVDMIPTNEQCLYRCTHNPRHFIGGLSKWQYGLPYNAYYGGVVSFTKEQYRKINGGSNLFFGWGGEDDDLMTRVQSKGYSLVRYPKMIGRYDTVSHNRDSGNGDNPQRFNLIRTSKFRQDREGLSTTKYKVTEVVKSQLFTKIKVFINMSEVLQVGFGDNDYRYSGYWRQSANHYSNLQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B1J5</accession>
    <name>A0A3S1B1J5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_014613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000566">
        <property type="protein sequence ID" value="RUS77613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B1J5"/>
    <dbReference type="STRING" id="188477.A0A3S1B1J5"/>
    <dbReference type="OrthoDB" id="6162398at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS77613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="280" mass="31660" checksum="89C1811D8AF957F3" modified="2019-04-10" version="1">MKFKVIQTDRQTDRQADRQADRQTGRQKRQTADRQTDRQTDRQTDRQTSIQLGTHSKNSAGRQTGRTDRQAGIQTGRQHRLQADRKAYNRQAGKQTGRQTRIQLGTHSEDSADRQTDRQTSIQICTHSENSAGRQTGRQTDRQADTHITWHTLRELCRQTDTQADRQAGRHEYSLAHTPRTLQADRQAGRQAGRQTDRQTGRQTDRQTNLQLGTHSENCAGRQTGRQTSIQICTHSENSAGRQTDRQAGGQLGTHSENSADRQTVGQGGDSAVRLKTTYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B1U2</accession>
    <name>A0A3S1B1U2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_019292</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000996">
        <property type="protein sequence ID" value="RUS72952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S1B1U2"/>
    <dbReference type="OrthoDB" id="6066315at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052579">
        <property type="entry name" value="Zinc_finger_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048325">
        <property type="entry name" value="ZSWIM3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21599">
        <property type="entry name" value="ZSWIM3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="6">
        <location>
            <begin position="504"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="653"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="827"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="919"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1316"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="667"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="681"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="696"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="858"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="921"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1319"/>
            <end position="1348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS72952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1389" mass="157216" checksum="C28B542B223C4E13" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B494</accession>
    <name>A0A3S1B494_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_020659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001192">
        <property type="protein sequence ID" value="RUS71581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B494"/>
    <dbReference type="OrthoDB" id="6146532at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS71581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="400" mass="44708" checksum="35879FD5729CD8B1" modified="2019-04-10" version="1" fragment="single">KFLSTCTDLDESKTLGGSYTRFCNNVFPPLIDSCNISGAVEFLDPEVEQACALYESVFDGKYRNMFCFLCNEPFPYDFMRLKNLVMTGFGANAARLDFAALLDLSGQMDDPVEETRTVEHCNVTQYLDVDTCECRELECSEGKYLSSSGACLSLLETDMLGYTACHRLDISSTEPLPVDRLRFASYMVVQTYAKEHIFQVLHFCPNGLNISLFFEDKVTSYGTLEDLEERIRSIRDVYRSMANDTLTSAVSSRVSVAYPCPRGPMLEDQCPSDPSFYMPPSRMEAPVMEGERTDTYYISYSPTSACPFVSIPRANFTLVEDGEKLLYKPTGNLIPTAQVSFIDSPDSDSGFVRVCISDYKELANSSFCRKDPVDDFDTWSVVGVISVISTVISLVCLVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B7G3</accession>
    <name>A0A3S1B7G3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_010661</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family. Platelet-activating factor acetylhydrolase IB beta/gamma subunits subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000329">
        <property type="protein sequence ID" value="RUS81587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B7G3"/>
    <dbReference type="STRING" id="188477.A0A3S1B7G3"/>
    <dbReference type="OrthoDB" id="505607at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01820">
        <property type="entry name" value="PAF_acetylesterase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11852">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11852:SF0">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE IB SUBUNIT BETA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="2">
        <location>
            <begin position="42"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS81587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="251" mass="27740" checksum="2B4955A658F66584" modified="2019-04-10" version="1">MSTRAAEPHPVEDVHGDGRWMSVHKHFLHDAKEKEPEVVLIGDSLIHNMICSPIWKLMFEPLHSLNLGVGCDRTENVLWRVLNGELDQIEPKVIVLMVGTNNHGDTAEQVTEGIMAIVKAILDKQPSSYLIVMGLLPRGEHPNPLREKHSAVNRLLSDQLANTPMTTFLQIDDQEFFLPGPKGGDPVTPSTGVIPRGLMHDFLHLTVDEGYQKLCDPLLEEIQNCLGTFVKVESTSFDTGSAAEDAALEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2022-12-14" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BCZ3</accession>
    <name>A0A3S1BCZ3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_011569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000379">
        <property type="protein sequence ID" value="RUS80665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BCZ3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS80665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="103" mass="11214" checksum="11BC656D1A3FA923" modified="2019-04-10" version="1" fragment="single">PPKPVVSYKDGSRLSCEFSATKTFSVQYQVEWVRGNITAATALLQNGVFESLLSVDLSDFSAGQKHFCSVRACYSNYCPGSNRNPNGTLSDAQVSDVFLPEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BDF5</accession>
    <name>A0A3S1BDF5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_010844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000339">
        <property type="protein sequence ID" value="RUS81406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BDF5"/>
    <dbReference type="OrthoDB" id="5981473at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028043">
        <property type="entry name" value="PAAT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14787:SF1">
        <property type="entry name" value="ATPASE PAAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14787">
        <property type="entry name" value="C10ORF188 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14958">
        <property type="entry name" value="PAAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS81406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="381" mass="42019" checksum="072668365371CEE5" modified="2019-04-10" version="1">MASNLCNLSFSWNNDRPPTGVTKFTYLDLTDANADLENGLELSGDERFAEDIESSNQTQILLTRHNSDEDSKHCIFQLTCPNPEFAQVNGISIVSESRTLEISSTDKGYLTTLRGKKVAESSQSSIQGLNTVNLYSCFYYFEESFPSLTIKFLSLGQRSSFFVQRIRINMLQHGLQSPRVNGTLDVGKLKKDIEDMGSTMSERAKDFMATLEQYEKNKMGKMNGILGSSLKSNSVGDNSNGLSSIMNSILGAGTMKSLSNPKVGSDGDKQDLFSILNSVCGSVANLRAPSVKQNTELCEATLSCDAETSNAMDTDAAQPSSHTLDLVNEKVERLRSDLKEELSEIRQEMFTKVEDVKSELNQKLDLVLNMLSALQPTKENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BDV2</accession>
    <name>A0A3S1BDV2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_010511</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Isomerization of 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(3E,5Z)-octadienoyl-CoA = (2E,4E)-octadienoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:45244"/>
            <dbReference type="ChEBI" id="CHEBI:62243"/>
            <dbReference type="ChEBI" id="CHEBI:85108"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(3E,5Z,8Z,11Z,14Z)-eicosapentaenoyl-CoA = (2E,4E,8Z,11Z,14Z)-eicosapentaenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:45224"/>
            <dbReference type="ChEBI" id="CHEBI:85090"/>
            <dbReference type="ChEBI" id="CHEBI:85091"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000323">
        <property type="protein sequence ID" value="RUS81704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BDV2"/>
    <dbReference type="STRING" id="188477.A0A3S1BDV2"/>
    <dbReference type="OrthoDB" id="14970at2759"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051750">
        <property type="term" value="F:delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000004">
        <property type="entry name" value="Delta3,5-delta2,4-dienoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000024">
        <property type="entry name" value="Delta3,5-delta2,4-dienoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045002">
        <property type="entry name" value="Ech1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004794">
        <property type="entry name" value="PRK06142.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149:SF1">
        <property type="entry name" value="DELTA(3,5)-DELTA(2,4)-DIENOYL-COA ISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS81704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="318" mass="35268" checksum="2058CA5756B6ABA7" modified="2019-04-10" version="1">MFSGLRTSLRLLGQQASKSFLKSSTEQNKSLVLCARAMSAAADKSYEFKTLKVHSPAEFVKHVELNRPERLNAMNMDFWREMVECFDKLAEDEDCRVVILSGSGKAFTSGLDLADNGLFQIIMADEDCSRKAFKMNKAIPKFQESFSAIEKCPKPVIAAVHSACIGGGIDMISACDIRFCTQDAWFQIKEVDVGLAADVGTLQRFPRIVGNDSLTRELVYTARKFYSDEAKSIGFVSRVLVDKDQMMKTALDMASTIAAKSPVAVQGSKINLVYSRDHSVPEGLDYNAKWNITMLQSEDVMKAASAFMNKTKPVFSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BE77</accession>
    <name>A0A3S1BE77_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_010286</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000313">
        <property type="protein sequence ID" value="RUS81941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BE77"/>
    <dbReference type="STRING" id="188477.A0A3S1BE77"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050129">
        <property type="entry name" value="Zn_alcohol_dh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401:SF2">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="32"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS81941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="369" mass="40474" checksum="A50481B91BE02C25" modified="2019-04-10" version="1">MTKAALNQNELRALRKLTGEPEVFSSSIQSSSLLSSSTCDAMSSMPVPDAPDSGLLVKISHAGACYLEGQTRNRRFTPQFPGNEVAGTVHEIGNNLPNANFTVGDRVMVLPKEDSINTGYAEYVPVDDINRVIQVPNRVPLEVAAMLPGDALKAYAAVNCAAPHVEKLRKVKSSVNILVIGGSSLGLWSVKLAKYMMGRNCNNVRLFVADNSIDRLLTAQDHGCYDIIHWNEEDHEQYIVERTLDSCRGGVDVIIDYVGTNRTMQRCLKVLNREGLILVGGNKPCETSISLSTLAAKQQSIVGVPRGNVNQLIQLLNAVQEKQVEIPAYKVFPVEDANHIFEEICECRITERAVFRFGSQSSGHLVDNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BEE9</accession>
    <name>A0A3S1BEE9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Receptor ligand binding region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_010126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000302">
        <property type="protein sequence ID" value="RUS82114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BEE9"/>
    <dbReference type="STRING" id="188477.A0A3S1BEE9"/>
    <dbReference type="OrthoDB" id="2150267at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS82114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="22025" checksum="0B2E3CEEB44EE0BF" modified="2019-04-10" version="1">MAAIDHSQLQKTTTLASNQRESTLTYFAFWTKAAILACVLSVCVCGPIEDTKTPLYVGGLWPMTGPGWRCGAETLPALELAVEVLNNSTDILPGHEIRLIWNDTRNCEDDDDDDEEEEELDDDDDDYDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDNDDDSVDDGDGAWVEMRGRDPPGLRASGGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BI57</accession>
    <name>A0A3S1BI57_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_003318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000071">
        <property type="protein sequence ID" value="RUS88879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BI57"/>
    <dbReference type="OrthoDB" id="6150789at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS88879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="314" mass="34984" checksum="B3EECCA7C206C8E5" modified="2019-04-10" version="1" fragment="single">MMDSRNKMTSMAGLAISITIMAALIPVALLVPVAVENERFVNIELLSEASNPDARVRREADSNLPDHLNFQVPMATGDITLRMKRSKLVRTATSHSEATTPFSENAAVYTDLEKGASMLVKREAGDYSLHGSFLHDNNEWNLEPLDRARRQASQTESESERRGSGSHRLFPGPPPDMQTISMVGDTVVDDEPPVEILSLADRNRHRQDRMRARSAGQSRDVSADQGQATSTGPQTRGGNRRSKREAVQHTVELVFVVDYADYEKWVSFKGASNAVNEMTLWYTYVAEAINIRYRSITDPDIAMSTVVTFLRILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BKW8</accession>
    <name>A0A3S1BKW8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_009101</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000256">
        <property type="protein sequence ID" value="RUS83154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BKW8"/>
    <dbReference type="STRING" id="188477.A0A3S1BKW8"/>
    <dbReference type="OrthoDB" id="6045558at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018596387" description="EGF-like domain-containing protein" evidence="5">
        <location>
            <begin position="30"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="35"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="145"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS83154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="258" mass="27843" checksum="28F0813328E4F735" modified="2019-04-10" version="1">MAQTSHQRSQHSEIVCFLIWLLFRPCYQAALSGMSNIVCPANCNQHGDCRLMHDRSVVACHCHRGWGGNSCELKCTKPCSNGTCFFAGSKQLCLCSPGFSGELCSRPGYDMTGLLHLAKIMTGTDLQLPLVRNPQQIVQANIDSGSSTCGENFVCQNGGVCVNGAMGGYRCECLTNEFTGNFCQHRCPRTCLNGGTCVRLRKARSSNQTGNSLSLPESQVAYGCACPEGYSGELCDRRRRAAVLGITMSTSEQPSAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BL74</accession>
    <name>A0A3S1BL74_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_005977</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000144">
        <property type="protein sequence ID" value="RUS86285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S1BL74"/>
    <dbReference type="OrthoDB" id="15627at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030155">
        <property type="term" value="P:regulation of cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023051">
        <property type="term" value="P:regulation of signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031865">
        <property type="entry name" value="DUF4757"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029978">
        <property type="entry name" value="LMO-7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46767:SF2">
        <property type="entry name" value="LIM DOMAIN 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46767">
        <property type="entry name" value="LIM DOMAIN ONLY PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15949">
        <property type="entry name" value="DUF4757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018575972" description="PDZ domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="1687"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="707"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="795"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1216"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1264"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1546"/>
            <end position="1687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="143"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
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            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="365"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="542"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="608"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="654"/>
        </location>
    </feature>
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        <location>
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            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
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            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1077"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1103"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1127"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1270"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1292"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="1415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1423"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1454"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1471"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1521"/>
            <end position="1530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1571"/>
            <end position="1594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1603"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1616"/>
            <end position="1655"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS86285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1687" mass="188088" checksum="90CC4A04ED4FC1AF" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BNW3</accession>
    <name>A0A3S1BNW3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Cytochrome P450 2U1</fullName>
            <ecNumber evidence="24">1.14.14.80</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="26">Long-chain fatty acid omega-monooxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">EGW08_007047</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">EC2010</strain>
            <tissue evidence="28">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="23">A cytochrome P450 monooxygenase involved in the metabolism of arachidonic acid and its conjugates. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Acts as an omega and omega-1 hydroxylase for arachidonic acid and possibly for other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes. May down-regulate the biological activities of N-arachidonoyl-serotonin, an endocannabinoid that has anti-nociceptive effects through inhibition of fatty acid amide hydrolase FAAH, TRPV1 receptor and T-type calcium channels. Catalyzes C-2 oxidation of the indole ring of N-arachidonoyl-serotonin forming a less active product 2-oxo-N-arachidonoyl-serotonin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:39759"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:76627"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:39760"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:39755"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:76624"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:39756"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + reduced [NADPH--hemoprotein reductase] + O2 = 2-oxo-N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50296"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:132255"/>
            <dbReference type="ChEBI" id="CHEBI:132256"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:50297"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>an omega-methyl-long-chain fatty acid + reduced [NADPH--hemoprotein reductase] + O2 = an omega-hydroxy-long-chain fatty acid + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56748"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:140991"/>
            <dbReference type="ChEBI" id="CHEBI:140992"/>
            <dbReference type="EC" id="1.14.14.80"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:56749"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.80" evidence="24"/>
    <dbReference type="EMBL" id="RQTK01000178">
        <property type="protein sequence ID" value="RUS85221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BNW3"/>
    <dbReference type="STRING" id="188477.A0A3S1BNW3"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102033">
        <property type="term" value="F:long-chain fatty acid omega-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000017">
        <property type="entry name" value="cytochrome P450 2U1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008069">
        <property type="entry name" value="Cyt_P450_E_grp-I_CYP2D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF375">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01686">
        <property type="entry name" value="EP450ICYP2D"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="18 27" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0492">Microsome</keyword>
    <keyword evidence="17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 27" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 27" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00051320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00052159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00052378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00058812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00066560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00067282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00079181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="RUS85221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="630" mass="71932" checksum="BF665B97B9DA2927" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BQC9</accession>
    <name>A0A3S1BQC9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_003224</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Plays an essential role in autophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Autophagosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000069">
        <property type="protein sequence ID" value="RUS88977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BQC9"/>
    <dbReference type="STRING" id="188477.A0A3S1BQC9"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF177">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018380920" description="Transmembrane 9 superfamily member" evidence="8">
        <location>
            <begin position="24"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="516"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="557"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS88977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="591" mass="67224" checksum="67CB056A26CAF88E" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BTL9</accession>
    <name>A0A3S1BTL9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADP-dependent 3-hydroxy acid dehydrogenase YdfG</fullName>
            <ecNumber evidence="4">1.1.1.298</ecNumber>
            <ecNumber evidence="5">1.1.1.381</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">L-allo-threonine dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Malonic semialdehyde reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_001168</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">NADP-dependent dehydrogenase with broad substrate specificity acting on 3-hydroxy acids. Catalyzes the NADP-dependent oxidation of L-allo-threonine to L-2-amino-3-keto-butyrate, which is spontaneously decarboxylated into aminoacetone. Also acts on D-threonine, L-serine, D-serine, D-3-hydroxyisobutyrate, L-3-hydroxyisobutyrate, D-glycerate and L-glycerate. Able to catalyze the reduction of the malonic semialdehyde to 3-hydroxypropionic acid. YdfG is apparently supplementing RutE, the presumed malonic semialdehyde reductase involved in pyrimidine degradation since both are able to detoxify malonic semialdehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>3-hydroxypropanoate + NADP(+) = 3-oxopropanoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:26438"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16510"/>
            <dbReference type="ChEBI" id="CHEBI:33190"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.298"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-allo-threonine + NADP(+) = aminoacetone + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:43524"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58320"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58585"/>
            <dbReference type="EC" id="1.1.1.381"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.298" evidence="4"/>
    <dbReference type="EC" id="1.1.1.381" evidence="5"/>
    <dbReference type="EMBL" id="RQTK01000019">
        <property type="protein sequence ID" value="RUS91040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BTL9"/>
    <dbReference type="STRING" id="188477.A0A3S1BTL9"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035527">
        <property type="term" value="F:3-hydroxypropionate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086:SF3">
        <property type="entry name" value="NADP-DEPENDENT 3-HYDROXY ACID DEHYDROGENASE YDFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086">
        <property type="entry name" value="VERY-LONG-CHAIN 3-OXOOACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS91040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="151" mass="16230" checksum="B9DABDCD97E4B19B" modified="2019-04-10" version="1">MMTSLHEDDWDKMVDVNCKGLLNGIGAVLGGMVERKKGHIVNISSDSGLKGFIGVSVYCGTKFFVEGVTESMRQEVAKHNVKVTTIQPGFVALDGPERAQKDPEAFALCSPPADLEVLQPENIAQAVLYAVSQPSFVAVNQMLVQPTGQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BTU2</accession>
    <name>A0A3S1BTU2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">E3 ubiquitin-protein ligase UBR4 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_003765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000081">
        <property type="protein sequence ID" value="RUS88507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BTU2"/>
    <dbReference type="STRING" id="188477.A0A3S1BTU2"/>
    <dbReference type="OrthoDB" id="30336at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045841">
        <property type="entry name" value="E3_UBR4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045189">
        <property type="entry name" value="UBR4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21725">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21725:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19423">
        <property type="entry name" value="E3_UBR4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E3 ubiquitin-protein ligase UBR4 N-terminal" evidence="2">
        <location>
            <begin position="44"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="545"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS88507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="762" mass="82532" checksum="FCD6555E39BCD668" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BU82</accession>
    <name>A0A3S1BU82_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_003376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000072">
        <property type="protein sequence ID" value="RUS88831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BU82"/>
    <dbReference type="STRING" id="188477.A0A3S1BU82"/>
    <dbReference type="OrthoDB" id="9973749at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000">
        <property type="entry name" value="HEMOGLOBINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000:SF42">
        <property type="entry name" value="LEGUMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS88831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="150" mass="16685" checksum="BFDC369BC0CCCBF2" modified="2019-04-10" version="1" fragment="single">KNWVLLIAGSNGYGNYRHQADVCHAYQIAHANGIPDEQIVVMMYDDIANNEYNPVQGNIINRPGGPNVYPGVPKDYTGDDVNAETFLAVLQGNKEKVKSLLGREGKNSDSADLHNETLQTQFTIVRQETNKSHVMQYGDTSFTNLPVEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BU94</accession>
    <name>A0A3S1BU94_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein 272</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_000768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000011">
        <property type="protein sequence ID" value="RUS91444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BU94"/>
    <dbReference type="STRING" id="188477.A0A3S1BU94"/>
    <dbReference type="OrthoDB" id="6157510at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040350">
        <property type="entry name" value="TMEM272"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33444">
        <property type="entry name" value="SI:DKEY-19B23.12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33444:SF7">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS91444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="21759" checksum="2BB015677DFCA175" modified="2019-04-10" version="1">MELVGPDTNWEIDNGASVTACQEILRTEMQSAFMTAAVALSMIVPVVMIALGIKYRDDCPLEPRVPVYLLVGGSFGALKISLMLWTSFRRRQQENMDSLYGLSGGITSHTYRSMDIILSLFLLVWHVLGTVWVLGIWKPRFKPLLHRPTQYCDRSLYFFSVSVIAGVYAVLALLLLGIGCLTCIYRSNGAHRSHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BVN1</accession>
    <name>A0A3S1BVN1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_002373</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000046">
        <property type="protein sequence ID" value="RUS89843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BVN1"/>
    <dbReference type="STRING" id="188477.A0A3S1BVN1"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000563">
        <property type="entry name" value="Guanine nucleotide-binding protein alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000007">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF231">
        <property type="entry name" value="GUANINE NUCLEOTIDE BINDING PROTEIN (G PROTEIN) ALPHA V1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="45"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="153"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="178"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="203"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="272"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS89843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="359" mass="41707" checksum="D7F4EB387D0C7C97" modified="2019-04-10" version="1">MGLCFSLDQEEEKARARSEAIDQRLQKWAKAESNVLNILLLGAAEGGKSTLVKQMKIIHHDGFSYEELMSFRPAVLENLVSSMKFVLSGMGLLRINLEKSANKKHAHTVLSTQYCYDEEHLMLVHVYEALRTLWKDRGVRTAVARGYEYELNDSAIYYFENMERLCSLKYVPTPTDVLRARVRTTGVIETWFKMDDVMIKMFDVGGQRSERRKWIQCFDNVKCVLFVVAISAYDMCLIEDPSMNRLEESLKLFSQICNNRFFIRSTMILFLNKLDLFQDKVKYSKRHLRYFFPDFPGPDKDVDAAARYIQHLFMMQVASPTKVVYPHFTTATDTSNIQVVFQVLMDSILRDNLRMTALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BW92</accession>
    <name>A0A3S1BW92_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_015746</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000658">
        <property type="protein sequence ID" value="RUS76492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BW92"/>
    <dbReference type="STRING" id="188477.A0A3S1BW92"/>
    <dbReference type="OrthoDB" id="10068240at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF248">
        <property type="entry name" value="PICKPOCKET 17, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 11" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="9 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS76492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="164" mass="18786" checksum="E7D15904CA75FE5B" modified="2019-04-10" version="1">MQQEVNTVLKTSRNLKACQSAEELRCALKIAVRFDENLDMCDCYRPCTETTFEKTVSSRNWPNPAYATLMASAACTSNSSVCATLPDKNQYDLREEFVKLVIHYEDLNYEELTESADYELDQFLSDVGGTIGLWIGLSLLSLFEIIHLFTDVFLYICCAHRRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BX35</accession>
    <name>A0A3S1BX35_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_015086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000606">
        <property type="protein sequence ID" value="RUS77151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BX35"/>
    <dbReference type="OrthoDB" id="6152692at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="521"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS77151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="582" mass="63243" checksum="95A3ABAD4E3651D5" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BY31</accession>
    <name>A0A3S1BY31_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_000451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000006">
        <property type="protein sequence ID" value="RUS91743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BY31"/>
    <dbReference type="OrthoDB" id="6107273at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS91743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="252" mass="29569" checksum="FB28CC3001FA6A80" modified="2019-04-10" version="1">MIPFVSPDEPRWRESVRQQMESELSRRVREALETPPLERIQKRNEVAKLQRESPDLNSHVLLDLSERERDFLRTKRWKALHARKLADQAGPEMTFMAHNHNHNHNHNHNHRSGHVAERTPHGQQIEFLFRDELSRSNHDEYPGVFGLGNLSEGIKNIRDEYSVSVSRYPGAKPKPRHFYTKEGFVKALKTGNLPQGMHFLNDSGTYIDKYGVIRNNDGPFWPVESVPMFSTPRFKWWTALSPEPLYFLLPWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BZC8</accession>
    <name>A0A3S1BZC8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_013412</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000487">
        <property type="protein sequence ID" value="RUS78827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BZC8"/>
    <dbReference type="STRING" id="188477.A0A3S1BZC8"/>
    <dbReference type="OrthoDB" id="270970at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017158">
        <property type="term" value="P:regulation of calcium ion-dependent exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061669">
        <property type="term" value="P:spontaneous neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04035">
        <property type="entry name" value="C2A_Rabphilin_Doc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000023">
        <property type="entry name" value="Double C2-like domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041282">
        <property type="entry name" value="FYVE_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043566">
        <property type="entry name" value="Rabphilin/DOC2/Noc2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047022">
        <property type="entry name" value="Rabphilin_Doc2_C2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001565">
        <property type="entry name" value="Synaptotagmin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45729">
        <property type="entry name" value="RABPHILIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45729:SF6">
        <property type="entry name" value="RABPHILIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02318">
        <property type="entry name" value="FYVE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00399">
        <property type="entry name" value="SYNAPTOTAGMN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="11">
        <location>
            <begin position="7"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="284"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="422"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="91"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS78827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="528" mass="57840" checksum="6DEA9CEDEA1D1DEC" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C4U7</accession>
    <name>A0A3S1C4U7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Alkaline phosphatase</fullName>
            <ecNumber evidence="2 11">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_009256</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="2 11"/>
    <dbReference type="EMBL" id="RQTK01000263">
        <property type="protein sequence ID" value="RUS82971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C4U7"/>
    <dbReference type="STRING" id="188477.A0A3S1C4U7"/>
    <dbReference type="OrthoDB" id="5818554at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018299">
        <property type="entry name" value="Alkaline_phosphatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF5">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00123">
        <property type="entry name" value="ALKALINE_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="218"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="8">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="502"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS82971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="546" mass="60364" checksum="83501C6B4DE11A89" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C628</accession>
    <name>A0A3S1C628_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dynein assembly factor with WD repeat domains 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_008273</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
            <location evidence="9">Cytoskeleton</location>
            <location evidence="9">Flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000223">
        <property type="protein sequence ID" value="RUS83967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C628"/>
    <dbReference type="STRING" id="188477.A0A3S1C628"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070286">
        <property type="term" value="P:axonemal dynein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000250">
        <property type="entry name" value="Dynein assembly factor with WDR repeat domains 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF744">
        <property type="entry name" value="DYNEIN ASSEMBLY FACTOR WITH WD REPEATS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="88"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="130"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="173"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="215"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="257"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="341"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="383"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS83967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="415" mass="46167" checksum="2F945C16D3DDABF7" modified="2019-04-10" version="1">MKLKRFLLRYYPPGIILEYEQGGILKTRSIDLLDLSPSTDVDKVVEEITQKEPLITPGKVEQVQKLVARLQEKIGQREDHHYYLFKVLRAHILPLTNVAFNKSGSSFITGSYDRTCKVWDTSSGEEVHTLDGHRNVVYAISFNNPYGDKIVTGSFDKTCRIWSFESGKCYNVYKGHTAEIVCVSFNPQSTQIATGSMDTTCRLWDVEKGTEVANLSGHTGEIISLSFSSTGSELITASFDNTVSLWDVRSHKRIHTLIGHKAEISSAQFNFDSSLIATGSMDGTCKLWDRASGRCTATLRGHSDEILDVGFDCTGQRVLTASADNTACCYSAVTHQQICKFFGHEGEISKITFNPQGTLVMTASADKTARLWDPDTGECKQVLEGHTDEIFSCAFNYEGNTIITGNKDNTCRVWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C7L2</accession>
    <name>A0A3S1C7L2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_007132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000181">
        <property type="protein sequence ID" value="RUS85127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C7L2"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS85127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="107" mass="11644" checksum="4A8411B1462C2833" modified="2019-04-10" version="1" fragment="single">MSSDSLYSDFPKEDNDKTEIFGRFPNNNTESARSNATSTSTSTSTADDVFILNNNNINNKHHHNNSNSSNSRNNIIFNNTSEVSSSPSRAGLHSSASRDSLTSLTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C9K3</accession>
    <name>A0A3S1C9K3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kringle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_005586</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000132">
        <property type="protein sequence ID" value="RUS86637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C9K3"/>
    <dbReference type="STRING" id="188477.A0A3S1C9K3"/>
    <dbReference type="OrthoDB" id="6157835at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.20.10">
        <property type="entry name" value="Plasminogen Kringle 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000001">
        <property type="entry name" value="Kringle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018056">
        <property type="entry name" value="Kringle_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038178">
        <property type="entry name" value="Kringle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050759">
        <property type="entry name" value="Serine_protease_kringle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24261:SF7">
        <property type="entry name" value="KRINGLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24261">
        <property type="entry name" value="PLASMINOGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00130">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00021">
        <property type="entry name" value="KRINGLE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50070">
        <property type="entry name" value="KRINGLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 3" id="KW-0420">Kringle</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018569323" description="Kringle domain-containing protein" evidence="6">
        <location>
            <begin position="24"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="890"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="domain" description="Kringle" evidence="7">
        <location>
            <begin position="523"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="461"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="772"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="461"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="772"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="801"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS86637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="918" mass="98922" checksum="F056F13587606B53" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1CFQ0</accession>
    <name>A0A3S1CFQ0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cilia- and flagella-associated protein 77</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_000801</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000011">
        <property type="protein sequence ID" value="RUS91477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1CFQ0"/>
    <dbReference type="STRING" id="188477.A0A3S1CFQ0"/>
    <dbReference type="OrthoDB" id="532484at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029147">
        <property type="entry name" value="CFAP77"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28617">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28617:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14825">
        <property type="entry name" value="CFAP77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS91477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="26892" checksum="1ECF8CEE78FF2724" modified="2019-04-10" version="1" fragment="single">DRVGHVKTRGFDLPGKGFAYGLPYDRREFSAANALQGWNGTYLTKGGATKTRSATERDFMYLNRAAIAGGLVKAPENSDYRATHDARRLPFDKKEMASKMRTRRLPPTMVFGIPSRPSTPIFDLLEHKYQDRWVKERQNQLSAKKSAEIKRRVMSAPVGSRNHGMIYETRASLLRTYQNPVDPAPLWQLPRFTKSAKPHIQTFRQDSAKAAAFRNLETDKIGRQGDFGTGIYEKPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H4I7</accession>
    <name>A0A3S1H4I7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Caspase recruitment domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_020194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001124">
        <property type="protein sequence ID" value="RUS72047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H4I7"/>
    <dbReference type="OrthoDB" id="6162700at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="397"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="434"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS72047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="532" mass="58195" checksum="34C92FA5B57DED9F" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SIX2</accession>
    <name>A0A433SIX2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_023287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001909">
        <property type="protein sequence ID" value="RUS68951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SIX2"/>
    <dbReference type="OrthoDB" id="6217368at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS68951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="273" mass="29221" checksum="8D9D8E71D3596433" modified="2019-05-08" version="1">MNPRILAAKEKMLDDLVGEFKDRLDIFSTEVKTKMRTSANEMANHTFEIVLLFLTQVFPDLSTLDSGPGSTLSGFEKDLAETKQSLAETKQSLSETKQSQTKQSLSETKQSLSETKQSLSETKKSLSETKQSHRFLSTKILKNEEKAILFKRQIKKLNKVSETNTHQIWGLRKLQKLLSNMTMTIQTAAAAAVAAAVPSAQATAAAPQSAQATAAAPSAQATAATPSAQATAATPQSAQATAATPRGPPKSLRHESTFSAKTAGDSRTPGIGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SQ20</accession>
    <name>A0A433SQ20_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chloride channel CLIC-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_020983</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chloride channel MCLC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001246">
        <property type="protein sequence ID" value="RUS71248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SQ20"/>
    <dbReference type="OrthoDB" id="10037397at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009231">
        <property type="entry name" value="Chloride_chnl_CLIC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34093">
        <property type="entry name" value="CHLORIDE CHANNEL CLIC-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34093:SF1">
        <property type="entry name" value="CHLORIDE CHANNEL CLIC-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="246"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="292"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS71248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="324" mass="36251" checksum="2F6F50FF6BA1474A" modified="2019-05-08" version="1" fragment="single">VLSSVFTRCILHPVELCGSTLGKALRAFFSEIPLQWQPAVMLVGTATALLLVLTATRYRLVIPMLLRLEPRTPVLTVSDTGDRHGDCQRRERGTCSGATGSASYIESPHDVHLQKYRYHNLQRGSRNLVHNLCDEKNSKYSGKEPNWENCGPEFSPTQNSCSVTHHNCRQSNDGEQNEIQPTPVVESLANEQFGRKSIPTSVEKCQNQRPSRLLRLFREDNSQETVDSTDSIGFKRNNLQRVLKTSSETVNSGRTRTQKRSTTSQFSKAPDGLLNDEKENSCKIPCATGKSTLKKSVRSRRRKGKGKTEDSLWSVDAEVISDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SRB0</accession>
    <name>A0A433SRB0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_020466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001161">
        <property type="protein sequence ID" value="RUS71772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SRB0"/>
    <dbReference type="OrthoDB" id="6114530at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS71772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="176" mass="19862" checksum="66C011EB11036368" modified="2019-05-08" version="1" fragment="single">LREAVRRRHYSTLRDAIDAVECSPFAKELPNSVQAARLLLDELAYQACCWSGEPVEHSMGYSSISEVRRFKSPPGCVVDSVKACFLLVSTPPSEVKTWPMMRALLCRTGRDSLLVQMATFDPGKLSVTQYKKADSLIRRWSEREVSAVSFEAGTFWAWANSALNRKYNQIGKKPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SS89</accession>
    <name>A0A433SS89_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NTR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_020099</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001106">
        <property type="protein sequence ID" value="RUS72140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SS89"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008191">
        <property type="term" value="F:metalloendopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001820">
        <property type="entry name" value="TIMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00965">
        <property type="entry name" value="TIMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="TIMP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019145871" description="NTR domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS72140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="16340" checksum="CE4C4286A75504CA" modified="2019-05-08" version="1">MNPVMTAALFAVVAMATQTLACENALTAEELQEFYCSSDVVFRGFNNRASSGFYRNMQGHRIQSASYTYRIEDMFKGTEPPSSSIVVRVTRNLDLDSCTQYVTDGQADSALVFASASGRFQMLETCRHSVPWSCVSESLRSSLSNITC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433STX2</accession>
    <name>A0A433STX2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_019516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001027">
        <property type="protein sequence ID" value="RUS72718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433STX2"/>
    <dbReference type="OrthoDB" id="5919401at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027967">
        <property type="entry name" value="DUF4612"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14974">
        <property type="entry name" value="SIMILAR TO RIKEN CDNA 1700025G04 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14974:SF3">
        <property type="entry name" value="SIMILAR TO RIKEN CDNA 1700025G04 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15389">
        <property type="entry name" value="DUF4612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS72718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="266" mass="27613" checksum="64DA92860C9A2AC0" modified="2019-05-08" version="1">MCVVGASAHVPQTMGCGKSRLRSPDNSDVDLKKNNSSGAGAGGNSNSNSGKASKKNSRNGGGKSNSGGIVGGNNKVGGGNVGEKQQQGGGDVTSSPSAQPQSAKKKKHFGGGNLASGGDKKSPEKDKDSHLEAKPPTSKKSQSNGKSVRPRERNDEIGVSPPRQPRLHPASSAQGAGQGETGGGFNGTNTSQPRSYVLEVPNEIPSTNTKTGMKDFKSLTASKIVHVTKSQIEFFRMLDEKIEKGDDYATSANTSEVSSLCDYERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SUN7</accession>
    <name>A0A433SUN7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_019265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000991">
        <property type="protein sequence ID" value="RUS72982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SUN7"/>
    <dbReference type="OrthoDB" id="6155671at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS72982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="287" mass="31618" checksum="62A11AC6A8CE9970" modified="2019-05-08" version="1" fragment="single">RARPAARPSGRRRGPSSERGFNLPVDCPSYAAAAFRRAPFPRRLAFNSQLRTVKRRAGLAPLDSGIKRGIAVRQGPLGVPTVRRAQSALKTVSGGEFDWGGTSVKSLPTPASGGNDMAAPEFAPRRLVEPRQEVFTVPPISAGGNLYDIHPMRRGGDKSFVDDLVLGRGVVISRAATSLRSVETQPLTRRFVRIRRATISDDGQGGALLLLIAPGFFLFAELEQLQLIQRRKLAYYGHIRRHCSIQKRVVEGKVEWKRGRGRKRHSWLANIQETSQIRLSVACEAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SWD9</accession>
    <name>A0A433SWD9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_018628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000918">
        <property type="protein sequence ID" value="RUS73605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SWD9"/>
    <dbReference type="OrthoDB" id="6047237at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS73605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="276" mass="31272" checksum="4468C68BBF0E349E" modified="2019-05-08" version="1">MKGGRRRILSTFYISKFGPGSSWPSPEVVLPPLGSAQAPQVSSAVRKRRVLDIGLSPRLTRQASDLKLRQNEAASSFPLPVDTKGRQPLPPLNSQDIRSVQNRGFPKQHSHGDVDNNQVLKQTCLVSAEERHSRNPYKLRRPTPFPVTPVVQNGALFHMLVKGKELKPVGIANDEETCASFYATHFPLLLRKLSETSEAVPAKRVMTEIEAEEQIKLSERRCRAREIRDRLEKAEDMLRQFETDPEDSGPIETELRSDLFNPATWPWNLERYSLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SY38</accession>
    <name>A0A433SY38_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein SDA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_018004</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for 60S pre-ribosomal subunits export to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the SDA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000852">
        <property type="protein sequence ID" value="RUS74236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SY38"/>
    <dbReference type="STRING" id="188477.A0A433SY38"/>
    <dbReference type="OrthoDB" id="2196187at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027312">
        <property type="entry name" value="Sda1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048292">
        <property type="entry name" value="SDA1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007949">
        <property type="entry name" value="SDA1_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012977">
        <property type="entry name" value="SDA1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730">
        <property type="entry name" value="HSDA/SDA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730:SF0">
        <property type="entry name" value="PROTEIN SDA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21638">
        <property type="entry name" value="SDA1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05285">
        <property type="entry name" value="SDA1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08158">
        <property type="entry name" value="SDA1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SDA1 N-terminal" evidence="10">
        <location>
            <begin position="65"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 middle" evidence="9">
        <location>
            <begin position="495"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 C-terminal" evidence="11">
        <location>
            <begin position="649"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="486"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="573"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="491"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="503"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="524"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS74236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="697" mass="80255" checksum="3A4FD62D55FE2657" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T0F5</accession>
    <name>A0A433T0F5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcription factor TFIIIC triple barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_017198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000776">
        <property type="protein sequence ID" value="RUS75043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T0F5"/>
    <dbReference type="OrthoDB" id="1877767at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042771">
        <property type="entry name" value="GTF3C6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019481">
        <property type="entry name" value="TFIIIC_triple_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21860:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21860">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIIC TFIIIC , POLYPEPTIDE 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10419">
        <property type="entry name" value="TFIIIC_sub6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor TFIIIC triple barrel" evidence="1">
        <location>
            <begin position="12"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS75043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="115" mass="12924" checksum="148340C3E00D6211" modified="2019-05-08" version="1">MAEKECDDSENEWEETLMMLQLPSRASNKKMEGDSYCQILGISSEQPLVKIKNHMFAGQLSQTMGTHIFLEIDNKLGSGPGKKNQIKEVTTSEKTMVLDPIYLETNKDKIAQDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T5J5</accession>
    <name>A0A433T5J5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_015463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000636">
        <property type="protein sequence ID" value="RUS76786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T5J5"/>
    <dbReference type="OrthoDB" id="6085853at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS76786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="242" mass="27526" checksum="F39E0B6DF0CE56A1" modified="2019-05-08" version="1">MGDSSTPVFDCGKVRPDPRHLNWVLPSPKRGMQATLHTGVPRRLLPTDICHDAEEYLATARRILHRQRMVNRMLPRFNRAKSANYAILLKEIHEAESSQIDHAHLPKFSKSVEAYQIPVFPGRRYTPSDVDKIVERLSTYDPMKIPESKGHHIKFEAPVLYKKKYTEEQLDSIVTRLAAYNPDTCPAESKGNPPVALPEPHRRSMSKVKRCTSQEVQEIVERLSAFDPSKWPPGSRSGVKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T771</accession>
    <name>A0A433T771_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_014790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000579">
        <property type="protein sequence ID" value="RUS77452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T771"/>
    <dbReference type="OrthoDB" id="2575524at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019008061" evidence="1">
        <location>
            <begin position="22"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS77452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="348" mass="38730" checksum="218967B2D302DCCE" modified="2019-05-08" version="1" fragment="single">MRHTDCLFLLVLALSAQVVLSRPTYNREECSQESGIDSASDNQTKCNLALEWRTCLMIPRHASKRGHFLQLQSMSVAIYTFCNRLSGDLALTSAKPNEDCITFVDECSNYLFLIQSSWLFKNKCIFIREWEECLRHVFWYCNLNDFDSSVTLSAVTTWSLSCSDYMYNGAPDGDDYHDYVDDDGDDDVATYAPDIDTGATTFATNAPFVDTDAPLDTEAPWVATDAPFVDSYYPIFYTDTPFVATDAPFVDAEAPFVDTDAPFLDTEAPFVDSDAPFVDSYYPIFYTDAPFVDTDAPFVATDAPFVDTDAPFVATDAPFVDTDAPFVATDAPFVDTDAPFVDTDAPFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T799</accession>
    <name>A0A433T799_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_014823</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000582">
        <property type="protein sequence ID" value="RUS77420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T799"/>
    <dbReference type="STRING" id="188477.A0A433T799"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000006">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000003">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="12">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="13">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="420"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="429"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS77420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="49897" checksum="0B2F06430C53180A" modified="2019-05-08" version="1">MREIVHLQCGQCGNQVGGKFWEVMSDEHGIDPTGTYHGDSDLQLERINVYFNEATGGKYVPRAILADLEPGTMDSVRSGPFGQIFRPDNFIFGQSGAGNNWAKGHYTEGAELCDSVLDVTRKEAEGCDCIQGFQLTHSLGGGSGSGLGTLLISKIREEYPDRIMSTYSIVPSPKVSDVVVEPYNATLSVHQLVENTDMTYAIDNEALYDICFRTLKLTTPTYGDLNHLISATLSGTTTCLRFPGQLNSDLRKLCVNMVPFPRLHFFIPGFAPLTSRGSQQYRAITVPELTQQMFDAKNMMAACDPRHGRYLTVACVFRGRMSTKEVDEQMLNVQNKNSSYFVEWIPSNVKTAICDIPPRGLKMSATFIGNTTALQELFKRIEEQFSAMFRRKAFLHWYTGEGMDEMEFTEAESNMSDLISEYQQYQDATAEEEGEMEEEEEEEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-05-03" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T7P6</accession>
    <name>A0A433T7P6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_014662</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000570">
        <property type="protein sequence ID" value="RUS77586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T7P6"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS77586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="146" mass="15282" checksum="3F56463D26651AEF" modified="2019-05-08" version="1" fragment="single">QSCPGVDIDLCSPQSCPYVDIDLCSPQSCPGVDIDLCSPQSCPGVDIDLCSPQHCPGVDIDLCSPQSCPGVDIDLCSPQHCPGVDIDLCSPHHCPGVDIDLCSHISPQYCPGVDIDLCSPHHCPGVDIDLCSPGLEMGPHATFSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T928</accession>
    <name>A0A433T928_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_014143</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000533">
        <property type="protein sequence ID" value="RUS78099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T928"/>
    <dbReference type="STRING" id="188477.A0A433T928"/>
    <dbReference type="OrthoDB" id="546826at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000180">
        <property type="entry name" value="serine/threonine-protein kinase STY46-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS78099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="145" mass="16179" checksum="305CD8C992ED1278" modified="2019-05-08" version="1" fragment="single">MKIGTGNFGEVYKGVYQKSLEVAVKTCKDTLTEDQKIKFLQEGRILKQYKHPNIVRYIGIAAQKQPVMIVMEFIPKGALLSFLKASGGSQTTRQLTQMCVDAASGMEYLEGRGCIHRDLAARNCLVGENNVIKISDFGMSREEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TAE0</accession>
    <name>A0A433TAE0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EGW08_013828</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">EC2010</strain>
            <tissue evidence="17">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TMTC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="5"/>
    <dbReference type="EMBL" id="RQTK01000511">
        <property type="protein sequence ID" value="RUS78414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TAE0"/>
    <dbReference type="STRING" id="188477.A0A433TAE0"/>
    <dbReference type="OrthoDB" id="19588at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013618">
        <property type="entry name" value="TMTC_DUF1736"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052384">
        <property type="entry name" value="TMTC_O-mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44216">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE TMTC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44216:SF3">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE TMTC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08409">
        <property type="entry name" value="TMTC_DUF1736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 13" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="470"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="532"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1736" evidence="16">
        <location>
            <begin position="281"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="572"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="606"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="685"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="722"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="858"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="391"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="391"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="409"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RUS78414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="909" mass="101367" checksum="6D7B11677072E2DC" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TAT7</accession>
    <name>A0A433TAT7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ApaG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_013523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000494">
        <property type="protein sequence ID" value="RUS78702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TAT7"/>
    <dbReference type="STRING" id="188477.A0A433TAT7"/>
    <dbReference type="OrthoDB" id="5913487at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1470">
        <property type="entry name" value="ApaG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007474">
        <property type="entry name" value="ApaG_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036767">
        <property type="entry name" value="ApaG_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011722">
        <property type="entry name" value="Hemimethylated_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036623">
        <property type="entry name" value="Hemimethylated_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003967">
        <property type="entry name" value="PRK05461.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14289">
        <property type="entry name" value="F-BOX ONLY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14289:SF16">
        <property type="entry name" value="POLYMERASE DELTA-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04379">
        <property type="entry name" value="DUF525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08755">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00992">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110069">
        <property type="entry name" value="ApaG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141255">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51087">
        <property type="entry name" value="APAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApaG" evidence="1">
        <location>
            <begin position="208"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS78702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="342" mass="39401" checksum="37C1C94A4A1E7175" modified="2019-05-08" version="1">MALNVFRKIALRAYITPLTALTLQKSCVRCLTTRLAEVGVLEPPRDHGQAYDTGQLFLHKIFGYRGIVLFPWLAHVYDRDVNNKVEERPPEDHNSAVGKEVKGKNHMYYQVLIDARDCPHIRAQTEAVTFLGNQDNSRALYAIPGLDYVAHEDVLPYYTPDSVPIQHELFDKFLMHDPQKTPSFVARETLGAWQEKNHPWLQLSDVHRETTENIRVTVTPFYMGCREAQQTHVYWWRYCVRLENRGVETVQLRERHWRIFSLSGTLETVRGRGVVGQEPVLSPEQPAFQYSSHVSLQAPSGHMWGTYKMERRDGTSFDCKIPPFSLESKTDDNSPNNTFLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TAV2</accession>
    <name>A0A433TAV2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_013587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nematode receptor-like protein srg family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000497">
        <property type="protein sequence ID" value="RUS78660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TAV2"/>
    <dbReference type="OrthoDB" id="6206419at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000609">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02118">
        <property type="entry name" value="Srg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS78660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="19587" checksum="BA64BE14C58070AB" modified="2019-05-08" version="1" fragment="single">ASHNSTVTPTRSLDSEVPVDGEFSDLTIEYASIVLKMYVNVGLGLGGIVANLINCVIFYTMGLSDGVSQNFLILSVSDGVVAAAYMVNFISYILLHSVFTADSANLETLLKVFNWSMGLIYLCQTISYITTTVIAIVRCCCVTMPLRVKRVWTVRRQLVTIVVSSLCVNLVNVVCLSLMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TBT9</accession>
    <name>A0A433TBT9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_013227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000477">
        <property type="protein sequence ID" value="RUS79016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TBT9"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS79016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="105" mass="11236" checksum="E3532F431F229CE9" modified="2019-05-08" version="1">MFHSIDIGPTYSSLESVKLRIQLWLYYNKLLPTLLPLCFFRTCTCIVLSLGVKQKKKKSGGSGSSSSSSSSSSSSSSSSSSSRISGSNNITCNSNVVGGWHVPQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TC32</accession>
    <name>A0A433TC32_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Telomeric repeat-binding factor 2-interacting protein 1</fullName>
            <shortName evidence="5">TERF2-interacting telomeric protein 1</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Repressor/activator protein 1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_013069</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Chromosome</location>
            <location evidence="5">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the RAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000467">
        <property type="protein sequence ID" value="RUS79161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TC32"/>
    <dbReference type="STRING" id="188477.A0A433TC32"/>
    <dbReference type="OrthoDB" id="435460at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070187">
        <property type="term" value="C:shelterin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031848">
        <property type="term" value="P:protection from non-homologous end joining at telomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010833">
        <property type="term" value="P:telomere maintenance via telomere lengthening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039595">
        <property type="entry name" value="TE2IP/Rap1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015010">
        <property type="entry name" value="TERF2IP_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16466">
        <property type="entry name" value="TELOMERE REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16466:SF6">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08914">
        <property type="entry name" value="Myb_Rap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="2 5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0779">Telomere</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BRCT" evidence="8">
        <location>
            <begin position="19"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="TERF2-interacting telomeric protein 1 Myb" evidence="7">
        <location>
            <begin position="145"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS79161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="232" mass="26850" checksum="D1037002300AF686" modified="2019-05-08" version="1" fragment="single">MAVRHQLTSSTFIRISRTLFMQEDAAPYTFYFAEQLQDLQKIIHRGGGELADSPREASYVLSENRLDCKGGKYLPLQFIVDCVKRNTFLNPEKYCQAHGIKSICAQDRPSTSTARDQCEDSDDEFFTRTSNILVSESATKGRSKYTDAEDLKIIRYLIFQKKCKETGGNMVWKEMQAAKLTDHTHQSMKARFKKKILPDIDSYDIPEFWKRQLTGEDSNPRDRRFSPRRNPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TC59</accession>
    <name>A0A433TC59_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_013096</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IL-17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000468">
        <property type="protein sequence ID" value="RUS79149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TC59"/>
    <dbReference type="OrthoDB" id="6147017at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010345">
        <property type="entry name" value="IL-17_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06083">
        <property type="entry name" value="IL17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS79149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="196" mass="22147" checksum="3C37885248521A54" modified="2019-05-08" version="1">MQIRQRLVLQLVVKAARSQSGLSGFESAPRTVGKVCAWCKVLQTRTWPKHQLARELNSFLADSDYLSVMPEQGDFIPLPTGQPYSCPAATGSWWPRREINLRSTCPWTWEELDNGPDAYPRYIRQAKCMCQKCIDSTINRCQEIRQDVTIFRLTGCQDGLAVMQKSEVTVTLGCFCAAPEPNTRADDQRVNSPSME</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TGD4</accession>
    <name>A0A433TGD4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ARID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_011561</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000379">
        <property type="protein sequence ID" value="RUS80657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TGD4"/>
    <dbReference type="STRING" id="188477.A0A433TGD4"/>
    <dbReference type="OrthoDB" id="1938591at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16869">
        <property type="entry name" value="ARID_ARID5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051232">
        <property type="entry name" value="ARID/SWI1_ChromRemod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964:SF44">
        <property type="entry name" value="ARID DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964">
        <property type="entry name" value="RBP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ARID" evidence="5">
        <location>
            <begin position="217"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="31"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="381"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="525"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="697"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="771"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="965"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1030"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="530"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="569"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="615"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="745"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="785"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="805"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1035"/>
            <end position="1044"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS80657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1056" mass="113630" checksum="8716290462227FF2" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TKT8</accession>
    <name>A0A433TKT8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vitellogenin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_010024</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000297">
        <property type="protein sequence ID" value="RUS82210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TKT8"/>
    <dbReference type="STRING" id="188477.A0A433TKT8"/>
    <dbReference type="OrthoDB" id="6484170at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045735">
        <property type="term" value="F:nutrient reservoir activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.230.10">
        <property type="entry name" value="Lipovitellin, beta-sheet shell regions, chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.80.10">
        <property type="entry name" value="Lipovitellin-phosvitin complex, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.50.20">
        <property type="entry name" value="Lipovitellin. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.20">
        <property type="entry name" value="Vitellinogen, superhelical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015819">
        <property type="entry name" value="Lipid_transp_b-sht_shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011030">
        <property type="entry name" value="Lipovitellin_superhlx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015816">
        <property type="entry name" value="Vitellinogen_b-sht_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015255">
        <property type="entry name" value="Vitellinogen_open_b-sht"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015817">
        <property type="entry name" value="Vitellinogen_open_b-sht_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050733">
        <property type="entry name" value="Vitellogenin/Apolipophorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001747">
        <property type="entry name" value="Vitellogenin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345:SF15">
        <property type="entry name" value="VITELLOGENIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345">
        <property type="entry name" value="VITELLOGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09172">
        <property type="entry name" value="Vit_open_b-sht"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01347">
        <property type="entry name" value="Vitellogenin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01169">
        <property type="entry name" value="DUF1943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00638">
        <property type="entry name" value="LPD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56968">
        <property type="entry name" value="Lipovitellin-phosvitin complex, beta-sheet shell regions"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48431">
        <property type="entry name" value="Lipovitellin-phosvitin complex, superhelical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51211">
        <property type="entry name" value="VITELLOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0758">Storage protein</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019496910" description="Vitellogenin domain-containing protein" evidence="6">
        <location>
            <begin position="19"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="Vitellogenin" evidence="7">
        <location>
            <begin position="42"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS82210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="841" mass="93302" checksum="A22C4DA1D32A185B" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TL27</accession>
    <name>A0A433TL27_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_010020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000297">
        <property type="protein sequence ID" value="RUS82206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TL27"/>
    <dbReference type="OrthoDB" id="6144929at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050528">
        <property type="entry name" value="L-type_Lectin-RKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27007">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="21"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS82206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="219" mass="24772" checksum="8FC30529C1704EAC" modified="2019-05-08" version="1" fragment="single">KSSSAFPLINLKGDFFKELPYTQGPVLGHGMSGDVILITRSDKPSEKRVLKRMAFKCRGSERAAKMLFMFELDTFYRTDHRGLAKCVLAARCPDYLAIVMKFYPLGDLDRSLFLLPAGSRHWVAARVSEAVEYLHMKRIVHSDIKLANILLDAGFTPVLGDFGLSRYLTEDVLTVAANKFGGTREYWAPEIRSRDASQQVDPFKVHFLNIILSTIREII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TL31</accession>
    <name>A0A433TL31_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_009979</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000294">
        <property type="protein sequence ID" value="RUS82268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TL31"/>
    <dbReference type="STRING" id="188477.A0A433TL31"/>
    <dbReference type="OrthoDB" id="6240251at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045609">
        <property type="entry name" value="DUF6451"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF25">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20049">
        <property type="entry name" value="DUF6451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="381"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS82268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="840" mass="96844" checksum="73BC7393F77BC5BE" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TL46</accession>
    <name>A0A433TL46_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_010007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000296">
        <property type="protein sequence ID" value="RUS82231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TL46"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019318477" evidence="1">
        <location>
            <begin position="17"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS82231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="111" mass="13135" checksum="C51208A4954C684C" modified="2019-05-08" version="1">MDLKLLLLFFISSCQRKNLNTDLQSRVINSHLYKTICLSYSWLVPISSGRRLIDLTNHRSTFIYSAFKKCKSFDYFRIHNCDILTLFAVPINCKRANNFIVTKSHLYQFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TRN2</accession>
    <name>A0A433TRN2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_008110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000217">
        <property type="protein sequence ID" value="RUS84136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TRN2"/>
    <dbReference type="STRING" id="188477.A0A433TRN2"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS84136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="225" mass="26486" checksum="4516BB39F4193073" modified="2019-05-08" version="1" fragment="single">QRHKQSVQRHGQNEQRHGQSVHRHEQSVQRQGQSVQRHGQNEQRHGQSVQRHGQSVQRHGQNEQTHGQSVKRHGQSVKRHGQRVQRYGQRVQRHGQSVQRHGQRVQRHGQSVQRHGQRVKRHGQSVQRHGQSVQRHGQSVQRHGQSVQRHGQRHGQSVQRHGQRHGQSIQRHGQRVQRHVQRVQRHGQSVQRHGQSVQRHGQSVQRHGQRHGQRVQRHGQSVQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TRW4</accession>
    <name>A0A433TRW4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_007891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000208">
        <property type="protein sequence ID" value="RUS84359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TRW4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS84359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="178" mass="19509" checksum="55CAC9B6E2272D45" modified="2019-05-08" version="1" fragment="single">MADCPRVISPRTGRGQLDHVTIVLFQLGLALAAFPIIVSGTTTDSVAFLDEATRYLGEDTRDFDEETRDFGERIDAFRQSSDMSTSGVLVIVLGLFAGSSLLIMAAGLFYLARWRTLKRKQDKALQAMPNDQTPDTDEELPGVYQSCGSLDMWTVESGCISLYELDVESGRVAPSGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TV07</accession>
    <name>A0A433TV07_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_006801</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000170">
        <property type="protein sequence ID" value="RUS85410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TV07"/>
    <dbReference type="STRING" id="188477.A0A433TV07"/>
    <dbReference type="OrthoDB" id="199913at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019533975" description="Lipase domain-containing protein" evidence="6">
        <location>
            <begin position="25"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="7">
        <location>
            <begin position="200"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="7">
        <location>
            <begin position="403"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS85410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="630" mass="70247" checksum="549C59C959AF5A57" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TV96</accession>
    <name>A0A433TV96_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_006719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000167">
        <property type="protein sequence ID" value="RUS85511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TV96"/>
    <dbReference type="OrthoDB" id="6137789at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS85511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="419" mass="46626" checksum="60738D4730941353" modified="2019-05-08" version="1" fragment="single">MAEDGPKPPPRYVRSCVTDKCSRAAPTYLNIEYPHSQTSSINPRSYGCGFSRDGRIIGSNLPVPYPRDTPFYHDLAFRRSVDWFAGGKFLGERKLDNDQPNDTFVEQCEHCQLRRMAASQRLCTSEGVEERGKPGCGRHGVKQILPGSAKKADVSGDGQGCEREDCYLIKDDPKYKAWVDGKSAARKEREKRHKEMKKTPWDVKLIPGHFAPPIRQTENETYGQHLDMLPRWPLVYPEVDVKPEPSPLTVKFRRSNMSDHPPIPDHSFAIARSEMETLDGVPLRGIIGAPYRPDTDTPAEALNCAMKNMESSGSDLKIPTQTTCNQGNPVTVVKGKGVTSNAPGLPVKDPWTFRRSAVVLGRVAGERGPGCTWPIYTPTGLEINRPIQRTVAMTAGCSYSDKNPHDTTIMADATKDLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TY60</accession>
    <name>A0A433TY60_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_005787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000138">
        <property type="protein sequence ID" value="RUS86472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TY60"/>
    <dbReference type="STRING" id="188477.A0A433TY60"/>
    <dbReference type="OrthoDB" id="6150370at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053151">
        <property type="entry name" value="RNase_H-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47723">
        <property type="entry name" value="OS05G0353850 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47723:SF19">
        <property type="entry name" value="POLYNUCLEOTIDYL TRANSFERASE, RIBONUCLEASE H-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="152"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS86472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="397" mass="44980" checksum="03AC3D5542F02863" modified="2019-05-08" version="1">MPREAPSELETRDKMVVVLKPPRDLTIITHLLVDSSNLVLKYITKDSKLLIQAAKFRRLPEHPMKDSMSQPVKRRLKRESFLHQVRSLEKKNQDMQGQNPKELPRCAKHPAWEEETSLQIHETIPGIGKKSSQNDLEKRSFAVEHIQTNYPATDWTHVYTDGSAEKAVRNGGAGIYIKYPGGEEDKISIPTGVFSTNYKAEATAIQEGAAHVQSSPHSTKNIVFLTDALSVLQALKSSKNKDLNDLTSALTSLSQTHTIALQWIPSHCNVFGNETADLLAKKAAALQQNDYTTTYSEAKTIIHAQQHEEWLQEHPNHVQNDAYHALTRAEQVVIFRLRTGHNRLNHHLYTKLHIGTSDQCTCQTGGQTLIHVLQHCPMYCLRYIIYSFYPRLLLNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U0J2</accession>
    <name>A0A433U0J2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_004917</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000114">
        <property type="protein sequence ID" value="RUS87305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U0J2"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019518062" evidence="3">
        <location>
            <begin position="31"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="384"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS87305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="508" mass="55245" checksum="59BC9B9A628E7EF5" modified="2019-05-08" version="1">MASLKKINRSVLFFLMGFPVLFRCAPESHGFRFSLTTPSSTVKALDVKVSIEPRPGKSSFEPWVAKGETVRPTSDPEVTYTEFATGDTKQASFIDKSSFGSRDFLDKMGVTSSDRNHKLPNDIDRISSAGREPTTIAAILTTDANNRVSNIMTAITDSNEPMSKSTNSKTDTSEPTSNTISTATDNSELMSYTTSKTTDNSEPTSYTTSKTTDHAEPTSYTTSKTIDHAEPTSYNTSKTTDNADPTSYTTSKTTYNSEPTSYTTSKTIDNSEPTSNAMNLITDSNESTSFSLNSVIDSNRSTSHSINSVNDSNESKIRQTREPGTPSTIHRDLLTVSDASVGATDKSALTSEDQQIVATDKDTDTIQEADKSSPPELYVFRAELVGAACLLLGVVILLVNIIAALLLQRRRLARKGSQSVLLWTPPFVKSACSGTLYSWAWDGTAGAARASGKEHPDTMDGLETGHETRLDALDLDLEAQNSSRKDSVRSPLQLSPSQLMWFKEKRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U467</accession>
    <name>A0A433U467_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NWD1/2-like winged helix-turn-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_003680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000079">
        <property type="protein sequence ID" value="RUS88580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A433U467"/>
    <dbReference type="OrthoDB" id="2325716at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052752">
        <property type="entry name" value="NACHT-WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057588">
        <property type="entry name" value="NWD1/2-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH_b-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19871">
        <property type="entry name" value="BETA TRANSDUCIN-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19871:SF14">
        <property type="entry name" value="DUF4062 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25469">
        <property type="entry name" value="WHD_NWD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="Soluble quinoprotein glucose dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NWD1/2-like winged helix-turn-helix" evidence="4">
        <location>
            <begin position="520"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1654"/>
            <end position="1673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1654"/>
            <end position="1663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS88580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1673" mass="186974" checksum="4C3C580D908D43BC" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U5D1</accession>
    <name>A0A433U5D1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_003213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000068">
        <property type="protein sequence ID" value="RUS89042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U5D1"/>
    <dbReference type="STRING" id="188477.A0A433U5D1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS89042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="109" mass="13932" checksum="82C99FAFCEB411E8" modified="2019-05-08" version="1" fragment="single">FTFPSACWYTCLSAYWYTCLPSYWYTCLPSYWYTCLTAYWYTCLLTYWYICLAAYWYTCLPVYWYTCLPTYWYTCLLFYWYTCLPPYWYTCLLFYWYTCLLFYWYTCLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U639</accession>
    <name>A0A433U639_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_002957</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000060">
        <property type="protein sequence ID" value="RUS89283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U639"/>
    <dbReference type="STRING" id="188477.A0A433U639"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="560"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="592"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="634"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS89283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="669" mass="72672" checksum="7A5926A8058C43C6" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U785</accession>
    <name>A0A433U785_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_002519</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000049">
        <property type="protein sequence ID" value="RUS89701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U785"/>
    <dbReference type="STRING" id="188477.A0A433U785"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS89701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="227" mass="23837" checksum="0A6B5FF2A43AF3B5" modified="2019-05-08" version="1" fragment="single">PIIPMMSAVLSSKPIIPMMSAVLSSQPIIPMMSAVLSSQPIIPMMSAVLSSQPIIPMMSDVLSTVPIIPMMAVFLSSQPIIPMMSAVLSSQPIIPMMSAVLSSQPIIPMMSAVLSSQPIIPMMSAVLSSQPIIPMMSAVLSSQPIIPMMSAVLSSQPIIPMMSAVLSSQPIIPMMSAVLSSQPIIPMMSAVLSSQPIIPMMSAVLSSQPIIPMMSAVLSSQPIIPMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UBH9</accession>
    <name>A0A433UBH9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_001067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000017">
        <property type="protein sequence ID" value="RUS91154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UBH9"/>
    <dbReference type="OrthoDB" id="6285231at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS91154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="113" mass="12955" checksum="6D880F0BFC0035D4" modified="2019-05-08" version="1">MAASGTNEHHEACRKQNFINRQTYLKKQIMAEADGQDNMACQAAMEEEIQRKLGSTPGHLGPLSSYDLEKLHRKHGSMGTDEERRRAVRQSQYLTYTAKINGRLSSVNYQQQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UBL9</accession>
    <name>A0A433UBL9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_001041</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000016">
        <property type="protein sequence ID" value="RUS91235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UBL9"/>
    <dbReference type="STRING" id="188477.A0A433UBL9"/>
    <dbReference type="OrthoDB" id="7458135at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14698">
        <property type="entry name" value="bZIP_CNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.880.10">
        <property type="entry name" value="Transcription factor, Skn-1-like, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004826">
        <property type="entry name" value="bZIP_Maf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047167">
        <property type="entry name" value="NFE2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008917">
        <property type="entry name" value="TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24411">
        <property type="entry name" value="NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24411:SF55">
        <property type="entry name" value="SEGMENTATION PROTEIN CAP'N'COLLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03131">
        <property type="entry name" value="bZIP_Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47454">
        <property type="entry name" value="A DNA-binding domain in eukaryotic transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="786"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="602"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="889"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="222"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="811"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="603"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="619"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="644"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="686"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="902"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="933"/>
            <end position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS91235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="942" mass="103658" checksum="F72D05F0059BF15E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UC48</accession>
    <name>A0A433UC48_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_000771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000011">
        <property type="protein sequence ID" value="RUS91447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UC48"/>
    <dbReference type="OrthoDB" id="10670315at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS91447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="355" mass="39165" checksum="E2ED65C873CDCAF3" modified="2019-05-08" version="1" fragment="single">LWCFGLTDAEGLSEVCIHSIVSFALSLGRLDPGPDGAELVLLSVVLAFKLVHAVGGVHPRIALEPDDFNRDYAVSRYLLFSSSQNGVYVLVCDLTVLGGKHVTGSVADHVEHLVLPKLVSVLRIAHHPTLLDDYIVQAEFHLSPLDDALLHCVFCDEPEHTDLLLLADTMGSILKRYTIDRNIDDEDRTHNINIHLRIPVRVKQNNDICSGQIDTQATSPGAQHENELCAIGVVEPHPPNNLAPYLSLFVRRLSIKAAVVIPAPETVVLQDIKHTLHLTILLESGQQLIQDDHFAAVFNQMIISCVGSLTWLHAVKQVRVVAAFPQLHEDVEQPHLVAAASAVYYVNVFHENLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UCV8</accession>
    <name>A0A433UCV8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_000533</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000007">
        <property type="protein sequence ID" value="RUS91707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UCV8"/>
    <dbReference type="OrthoDB" id="6161317at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019067674" evidence="2">
        <location>
            <begin position="26"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS91707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="156" mass="17136" checksum="CA1354212F609964" modified="2019-05-08" version="1">MSSMISYALPVLVLAVLTYFQPAHAAPRQRLSLADLREAFAKPPLHKFYLPIEIAPAALVGAFKAHARNMDGDALEDPLDFIQQKRTTSSVEVAEPLSAAEIVQHPFVFNGMKRKMFWQPLGYMPASARAQNNAGKTANTGRSSNQDTGSNVFRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UD39</accession>
    <name>A0A433UD39_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_000535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000007">
        <property type="protein sequence ID" value="RUS91709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UD39"/>
    <dbReference type="STRING" id="188477.A0A433UD39"/>
    <dbReference type="OrthoDB" id="5848685at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051952">
        <property type="entry name" value="Golgi-autophagy_related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23157:SF24">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23157">
        <property type="entry name" value="GRIP AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58100">
        <property type="entry name" value="Bacterial hemolysins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="497"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="81"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="353"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="517"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS91709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="539" mass="61841" checksum="FB9B1B9A2EF4D6FD" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z1M0</accession>
    <name>A0A3S0Z1M0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_023480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01002035">
        <property type="protein sequence ID" value="RUS68758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z1M0"/>
    <dbReference type="STRING" id="188477.A0A3S0Z1M0"/>
    <dbReference type="OrthoDB" id="6122020at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF7">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="469"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS68758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="58168" checksum="C5D365DD4E4CE93C" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z747</accession>
    <name>A0A3S0Z747_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_021339</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001310">
        <property type="protein sequence ID" value="RUS70895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z747"/>
    <dbReference type="STRING" id="188477.A0A3S0Z747"/>
    <dbReference type="OrthoDB" id="5982854at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05481">
        <property type="entry name" value="retropepsin_like_LTR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF8">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13975">
        <property type="entry name" value="gag-asp_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="362"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="543"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="504"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS70895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="696" mass="79135" checksum="738757B81039EA8D" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z8C9</accession>
    <name>A0A3S0Z8C9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_019177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000981">
        <property type="protein sequence ID" value="RUS73062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z8C9"/>
    <dbReference type="OrthoDB" id="43122at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS73062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="145" mass="16483" checksum="F5D8201C7110BF37" modified="2019-04-10" version="1" fragment="single">QLFVPDKVLIPERYDAEADAEQLTEEESLARKERAERIRKVLTSQSVLSMSQPDVSQLAGEDIHSRVRQEKKEREHFLALNQELARQVTLKSKKQAAERRKTWSGAQFADAKAQYEAELAGSPSSSPLRSPDSDRKRAEITLHDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZAW9</accession>
    <name>A0A3S0ZAW9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_021502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001343">
        <property type="protein sequence ID" value="RUS70735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZAW9"/>
    <dbReference type="OrthoDB" id="6043197at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018604230" evidence="1">
        <location>
            <begin position="20"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS70735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="296" mass="34785" checksum="655982F8B3C42869" modified="2019-04-10" version="1">MRALLIILLAICILAEISGARDRDRRKRRRPMCITEPRLRDKWHIAGENRRVFIRIRPHQVVYRHGATMIKYRCLENRRNIFLLRKRKYEKDKDGVLCLGFSYVADHPRGEYSVIRLIGKGEGSNLLSPVLVPRKSQVSINTTCDLEDRHFRLPDQRHYITQAIIRRSAPGCKFPKSIQGRWNFTYQHAKSLEIWQRNSTLHLMDGSSVRFLCDKRDGPVFVFRSRRYVSEQQDAIMCVEFTPMENDPFYSFEMSRHNSGSYLDGQLKAVPKSESVYVHVHCDWIGSPARPEYLYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZG57</accession>
    <name>A0A3S0ZG57_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoleucine--tRNA ligase cytoplasmic ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_014131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000532">
        <property type="protein sequence ID" value="RUS78123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZG57"/>
    <dbReference type="STRING" id="188477.A0A3S0ZG57"/>
    <dbReference type="OrthoDB" id="6284831at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057033">
        <property type="entry name" value="Ubiquitin_IARS1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23567">
        <property type="entry name" value="Ubiquitin_IARS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isoleucine--tRNA ligase cytoplasmic ubiquitin-like" evidence="2">
        <location>
            <begin position="120"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Isoleucine--tRNA ligase cytoplasmic ubiquitin-like" evidence="2">
        <location>
            <begin position="223"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS78123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="300" mass="32502" checksum="68EBE214F6472AA7" modified="2019-04-10" version="1">MTRITYFFHVQANLSPTDNIRVYYQATQKLVKILEEFSDFIHSTVKQPLQEYPVPSTGEIIITKKLPIKNDDFEITITWGEGGKRQLGAGDASSKSGRSNLSPSSSSDLPVAPQAKNAPPACKYVNLVLCSGLKSAQGRTGKTATLLLENPSGVNGLSHTAFVEQIQSVFGIRGLGVQLYLDSALTQEVNGDAPVTALAGQMVYITYPVGRTEGSLTSNVGWPVCHYVNIEGKSKKGTLLLENPRGDVLSLEEVQAQAATVMGVPLKKLKLSQTKEKMSAVTDKELQSLSTLHGRTLYMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZIR9</accession>
    <name>A0A3S0ZIR9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_012332</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000422">
        <property type="protein sequence ID" value="RUS79894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZIR9"/>
    <dbReference type="STRING" id="188477.A0A3S0ZIR9"/>
    <dbReference type="OrthoDB" id="10070555at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="209"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS79894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="564" mass="67352" checksum="B03B0519D5E0AD5F" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZIZ8</accession>
    <name>A0A3S0ZIZ8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kibra</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">EGW08_013373</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">EC2010</strain>
            <tissue evidence="19">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. Kibra acts synergistically along with Ex and Mer to regulate the Hippo signaling pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Forms a complex with Mer and Ex. Interacts (via domain WW 1) with Ex (via RXPPXY motif). Interacts with Mer, Sav, Hpo and Wts.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WWC family. KIBRA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000485">
        <property type="protein sequence ID" value="RUS78868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S0ZIZ8"/>
    <dbReference type="OrthoDB" id="2020426at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019900">
        <property type="term" value="F:kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046621">
        <property type="term" value="P:negative regulation of organ growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035330">
        <property type="term" value="P:regulation of hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051105">
        <property type="entry name" value="WWC/KIBRA_Hippo_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057747">
        <property type="entry name" value="WWC1_hairpin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14791">
        <property type="entry name" value="BOMB/KIRA PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14791:SF29">
        <property type="entry name" value="PROTEIN KIBRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25802">
        <property type="entry name" value="WWC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="468"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="18">
        <location>
            <begin position="9"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="18">
        <location>
            <begin position="56"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="17">
        <location>
            <begin position="896"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="679"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="759"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1029"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1106"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1726"/>
            <end position="1763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="692"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="768"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="786"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="802"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="842"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1031"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1753"/>
            <end position="1763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RUS78868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1763" mass="192968" checksum="37BDD1BAFFA8D597" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZJI6</accession>
    <name>A0A3S0ZJI6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_016004</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000679">
        <property type="protein sequence ID" value="RUS76231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZJI6"/>
    <dbReference type="STRING" id="188477.A0A3S0ZJI6"/>
    <dbReference type="OrthoDB" id="5600002at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008116">
        <property type="entry name" value="SSDP_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12610">
        <property type="entry name" value="SINGLE STRANDED DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12610:SF23">
        <property type="entry name" value="SINGLE-STRANDED DNA-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01743">
        <property type="entry name" value="SSDNABINDING"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS76231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="74" mass="8782" checksum="953360CE12DC1CBF" modified="2019-04-10" version="1" fragment="single">RLALYVYEYLLHVGAQKSAQTFLSEIRWEKNITLGEPPGFLHSWWCVFWDLYCAAPERRETCDHSSEAKAFHDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZKV8</accession>
    <name>A0A3S0ZKV8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_010992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000348">
        <property type="protein sequence ID" value="RUS81250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZKV8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS81250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="547" mass="62869" checksum="D392956775DB5E67" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZMU8</accession>
    <name>A0A3S0ZMU8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_021138</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001273">
        <property type="protein sequence ID" value="RUS71105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZMU8"/>
    <dbReference type="OrthoDB" id="6126039at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="41"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS71105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="293" mass="32642" checksum="5AD16B611165F86E" modified="2019-04-10" version="1">MMTPRTTPLYFDFMDEQKRKMAEIVMDYVIIFSISVIGIVTNSLVILVYAKLGFKESVAVSMTTISVWDLIKCIAGVLNNFAGILFLCDPVAATSWLNISSAIFNLLICFSSYVTSVMAAYVAVERCLCVSVPLKVKWMLTPKVTLIACLTISVVVFGAFAVMFGIYDIIWVHDDTLNATVAIYKKSKFSVQNEGPLFAYYNLSGIVWPLAAFIVILVSTIIIIVKLRQGSKFRAGQSGSSSQNEGHSSQNKGQTQQQRQQQNFLRRDRQVVKMLLVIIIIYIACLARESPNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZPV1</accession>
    <name>A0A3S0ZPV1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine/threonine-protein kinase ULK3</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Unc-51-like kinase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">EGW08_019743</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">EC2010</strain>
            <tissue evidence="19">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="RQTK01001061">
        <property type="protein sequence ID" value="RUS72489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZPV1"/>
    <dbReference type="STRING" id="188477.A0A3S0ZPV1"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14121">
        <property type="entry name" value="STKc_ULK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.80:FF:000008">
        <property type="entry name" value="serine/threonine-protein kinase ULK3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF65">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ULK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0072">Autophagy</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="19"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="363"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="528"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="388"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="408"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RUS72489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="550" mass="62560" checksum="F63E742F42BE3EA8" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZQD3</accession>
    <name>A0A3S0ZQD3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_008932</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000249">
        <property type="protein sequence ID" value="RUS83310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZQD3"/>
    <dbReference type="STRING" id="188477.A0A3S0ZQD3"/>
    <dbReference type="OrthoDB" id="3205605at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="94"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS83310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="319" mass="35798" checksum="5F8A0F1C51C9D3C4" modified="2019-04-10" version="1" fragment="single">MGNSNKSSLRKAQSVPDTQRLPPDAPVFMKVSKSQSQQRLNQSLGKASGSKFGKLHKDKSHSKSAAEGIPQLAPAEAAFLPDFPIRGDLEELDFEVINVIAHGAYGNVIKVQREDSKRFYAMKVLDKQQIIQEGAIRQCKDEAAIQSMAGDHPLVVKAYEYWQSHSNLYIVLDYIPHGDMFTLWTFHGAFPEALVQLYIAEMAMVIDYLHNSSVIYRDIKMENILFDQKGHIQLTDFGLAKWLQGGEQTRTVCGTLQYMAPEVLSVYPYGHSADWWSLGILMYAMLAGRYPVDGADTHTRMAQKVFDCDYLLPSNVSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZRL8</accession>
    <name>A0A3S0ZRL8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_011098</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GAS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000354">
        <property type="protein sequence ID" value="RUS81112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZRL8"/>
    <dbReference type="STRING" id="188477.A0A3S0ZRL8"/>
    <dbReference type="OrthoDB" id="2250192at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008093">
        <property type="term" value="F:cytoskeletal anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051764">
        <property type="term" value="P:actin crosslink formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21204">
        <property type="entry name" value="CH_GAS2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.20">
        <property type="entry name" value="Gas2-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003108">
        <property type="entry name" value="GAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036534">
        <property type="entry name" value="GAR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46756:SF13">
        <property type="entry name" value="GROWTH ARREST-SPECIFIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46756">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02187">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00243">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143575">
        <property type="entry name" value="GAS2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51460">
        <property type="entry name" value="GAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="69"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="GAR" evidence="7">
        <location>
            <begin position="263"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="212"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="342"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="216"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="257"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="369"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS81112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="44134" checksum="A78DF44BF005B150" modified="2019-04-10" version="1">MPLPFRSLTPSASSSATSPRPITKEVANAPKKEPLDFTDGRSSQDLSNDGSEVDQISLKLSELQGELFLSLKEDIAEWITKTLGDDVQIDAQNFIHALDTGVILCTLSMAIEERAREAYRQGVIKEPLPDYKLHCNKTAKSGTWFARDNTANFLKWCRTFGMTDETLFDSEDLVTHHQERQVIYCLMELARLGARFGLEPPTLISMEKEIDNEEPLPLPPPMRADPPTPHESPPPTPPIVEKSPPPTPTPPPRKDSTGSSKGSTLSTLDSEVSRVSNQCKCQEYVNKLSEGVYNVFGKRVFIRLLKGKHLMVRVGGGWDTFENYLLHHDPIQVFEFHQGGLPGSSHSTVSARPSTAGPAHSHSFAVARNDFKPDEPPSETAKEGFLRRMRRNYKSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZT45</accession>
    <name>A0A3S0ZT45_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_006961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000176">
        <property type="protein sequence ID" value="RUS85260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZT45"/>
    <dbReference type="OrthoDB" id="6162243at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050801">
        <property type="entry name" value="Ca-Dep_Lectins_ImmuneDev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801:SF63">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801">
        <property type="entry name" value="LITHOSTATHINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018596380" description="C-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="42"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="222"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="403"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="567"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS85260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="709" mass="80364" checksum="9FA29A46879C2E2F" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZTI7</accession>
    <name>A0A3S0ZTI7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_009790</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000286">
        <property type="protein sequence ID" value="RUS82444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZTI7"/>
    <dbReference type="STRING" id="188477.A0A3S0ZTI7"/>
    <dbReference type="OrthoDB" id="265044at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS82444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="240" mass="27185" checksum="97020816AE21B3B4" modified="2019-04-10" version="1">MLITTANNIPESKVQAFLQKYWSETGPACSNMLLLTDTKSHIPSPTWMPAKKLPEDCFDEQGRPPLISTVTVVGEATVGKTSIIQRFRTDKFTRAYTPTIGVERTQIVLDLPTEEMDQRILFRFLDTNDVILEPSMALTLKDKLDALHASLSRYVFVVYDITNHKSFEAAKDWVRLVKQMVGIDFQMFLVGNKADVKKHRAVHKTAGQVFALLNNMTFLETSAKTGYHIQTLFNLLVKCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZUN7</accession>
    <name>A0A3S0ZUN7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_005074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000118">
        <property type="protein sequence ID" value="RUS87142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZUN7"/>
    <dbReference type="STRING" id="188477.A0A3S0ZUN7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS87142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="226" mass="24952" checksum="3B80F98635EA626D" modified="2019-04-10" version="1" fragment="single">CPQSCSLCYHKPRSSSTLYPQSCSLCYHKPRSSSTLCPQSCSLCYHKPRSSSTLCPQSCSLCYHKPRSSSTLCPQSCSLCYHKPRSSSTLCPQSCSLCYHKPRSSSTLCPQSCSLCYHKPRSSSTLCPQSCSLCYHKPRSSSTLCPQSCSLCYHKPRSSSTLCPQSCSLCYHKPRSSSTLCPQSCSLCYHKPRSSSTLCPQSCSLCYHKPRSSSTLCPQSCSLCYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZV85</accession>
    <name>A0A3S0ZV85_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Vesicle-trafficking protein SEC22b</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">SEC22 vesicle-trafficking protein homolog B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">EGW08_008525</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">EC2010</strain>
            <tissue evidence="23">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Golgi apparatus</location>
            <location evidence="16">cis-Golgi network membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Melanosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000233">
        <property type="protein sequence ID" value="RUS83729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZV85"/>
    <dbReference type="STRING" id="188477.A0A3S0ZV85"/>
    <dbReference type="OrthoDB" id="1719357at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15866">
        <property type="entry name" value="R-SNARE_SEC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000004">
        <property type="entry name" value="vesicle-trafficking protein SEC22b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044565">
        <property type="entry name" value="Sec22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45837">
        <property type="entry name" value="VESICLE-TRAFFICKING PROTEIN SEC22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="21">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="22">
        <location>
            <begin position="136"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00033315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="RUS83729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="217" mass="25149" checksum="07585875A29E7D97" modified="2019-04-10" version="1">MVMLTMIARVADGLPLSASVQEDEQSGRSMVEYQTQAKQLFRKLSQDPNPPARCTLEATNYFFHYMIERGVCYLVLCEKSFSKRLAFSYLEDLQNEFNSQYGSRLDTVSRPYSFIEFDTYMQKARKSYMDSRARRNLGQINTELQDVQRIMVQNIDEVLMRGEALSVLDSKASNLSTMSQKYKKDAKYLNLRSSYAKIAAVVILVILLLLFLRYLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZWJ4</accession>
    <name>A0A3S0ZWJ4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_015181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000614">
        <property type="protein sequence ID" value="RUS77044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZWJ4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS77044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="242" mass="26527" checksum="C5377AE4F52EAD4A" modified="2019-04-10" version="1">MDCWPCGRDLALDNPADWEDILNGESEIKNKHWPVSVREPCCPELGTPTPKEKELSSPSPCPRDHFSQRCRMVRCTSRALFERGDAFQYGNHKAVKANKTIRTMCFLVGWLVCLGHHILAISQEIGKSGSQNPPKRVGNGRTSSASLTTPYEEGGHTVVTLVSRKADLTDRQTGGRAIRRIDGCPMSKVGKHVGYANKISCSVNVCSNSSGNSRGTEGEPMGFQLCLAKVEICRLDLDLLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A0I8</accession>
    <name>A0A3S1A0I8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial thiamine pyrophosphate carrier</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Solute carrier family 25 member 19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EGW08_001532</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">EC2010</strain>
            <tissue evidence="15">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mitochondrial transporter mediating uptake of thiamine diphosphate into mitochondria. It is not clear if the antiporter activity is affected by the membrane potential or by the proton electrochemical gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>thiamine phosphate(out) + thiamine diphosphate(in) = thiamine phosphate(in) + thiamine diphosphate(out)</text>
            <dbReference type="Rhea" id="RHEA:73383"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000026">
        <property type="protein sequence ID" value="RUS90728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A0I8"/>
    <dbReference type="STRING" id="188477.A0A3S1A0I8"/>
    <dbReference type="OrthoDB" id="18574at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090422">
        <property type="term" value="F:thiamine pyrophosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000011">
        <property type="entry name" value="Mitochondrial thiamine pyrophosphate carrier 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="12"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="117"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="216"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RUS90728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="324" mass="36034" checksum="36FD324DD2B40753" modified="2019-04-10" version="1">MVGYDPKDKVHLSATEHACAGAVSGALSRAIIQPLDVLKIRFQLQVEPLNKAADPKYYGMLQASRKIIGEEGIKAMWKGHIPAQILSIAYGVAQYGSFEFLTQKVWHYLPETLTTTYRPITHTICGGLSGCMGAAFVHPVDVIRTRFVAQGEPKVYKNLIHAIQSIMVKDGIQGYYRGLVPAVSLVGPQMAAQFGLYAFFSRMWDNSVKKLVPAIPSSVDHFICGSGAGFFAKLFVYPLDVVKKRLQVQGFEEARQSFGVVRKYNGIFHCFFVSLRDEGVQFMFKGLSPSLLKSSAVAGINFCVYEYCCLILVHYRKSLQPEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A294</accession>
    <name>A0A3S1A294_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_003473</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000074">
        <property type="protein sequence ID" value="RUS88756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A294"/>
    <dbReference type="OrthoDB" id="10599719at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS88756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="100" mass="10339" checksum="9367C268BCF9C1D9" modified="2019-04-10" version="1" fragment="single">CVGCNVHTLCVGCNVRTHCVGCKVQTVCVGCNVQTLCVGCNVHTLCVGCNVHILCVGCNVHTLCVGCNVHTLCVGCNVQTLCVGCDVHTLCVGCNVQTLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A826</accession>
    <name>A0A3S1A826_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_007277</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000187">
        <property type="protein sequence ID" value="RUS84966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A826"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS84966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="221" mass="24628" checksum="FBD727572687767C" modified="2019-04-10" version="1">MSSLMIVSDASESWRCDRVKRIPSPEPQTGAALPDDGGALQFKISTRPPKSPPLSVVQGEKWSLGLCGPFDLPRFLGKQGTRLWVVRTLRGRPSDPLLNVVNAFEQISLNLFWSTRFAYLVARLARSCSDRANNRSMFNDTLTESLIDKRSFHMRHPIIPWEISAVVMSIGGGEDSRPSSIPSPQHLRLIPVSTRFYLLGSPSDPRTWDNVCQNNGKPSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A9B2</accession>
    <name>A0A3S1A9B2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_006283</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000155">
        <property type="protein sequence ID" value="RUS85954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S1A9B2"/>
    <dbReference type="OrthoDB" id="423559at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18070">
        <property type="entry name" value="DEXQc_SHPRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15547">
        <property type="entry name" value="PHD_SHPRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16569">
        <property type="entry name" value="RING-HC_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000013">
        <property type="entry name" value="E3 ubiquitin-protein ligase SHPRH isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052583">
        <property type="entry name" value="ATP-helicase/E3_Ub-Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048686">
        <property type="entry name" value="SHPRH_helical_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048695">
        <property type="entry name" value="SHPRH_helical_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21325">
        <property type="entry name" value="SHPRH_helical-1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21324">
        <property type="entry name" value="SHPRH_helical-2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="1288"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="1367"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="249"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="441"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1507"/>
            <end position="1714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="255"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1507"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1532"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1558"/>
            <end position="1575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1589"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1600"/>
            <end position="1632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1648"/>
            <end position="1661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1662"/>
            <end position="1694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1695"/>
            <end position="1714"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS85954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1714" mass="191420" checksum="EBAF9E274A514446" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A9H2</accession>
    <name>A0A3S1A9H2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_006162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000151">
        <property type="protein sequence ID" value="RUS86069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A9H2"/>
    <dbReference type="OrthoDB" id="6077063at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS86069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="327" mass="35981" checksum="AE4E321F24D42D29" modified="2019-04-10" version="1">MLTAAPETQSCWRAARPCAMAESQTNDDVSCWAWYRCEEGGDYVIKWRCNADPALSENGSTISLCSDQSSLSSGFSNCPPPIVCADDPKQRAPIIVPEPGYLSTDLILVIAVVSFAVIAVLLTIGSSYKYWSLRRKFRFPIRPGRYVMREFPHPVRYHNHWGTRYSLSNPTSDTTKRPPSSLSGDLHTLFPELNKSRLNLMNVNGLRSHSHHPDTASRSFVYPDVYISKHSSETVAVPRPRPTFPPSHGHSVKPAGGSRKDHSSGASVRAQESVPSGPFGVPGNVDQDGTIKRDSTEAAGSFVYHDPWGGGNPLWRFAGQATWRGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AAN6</accession>
    <name>A0A3S1AAN6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATPase protein 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">ATPase subunit c</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EGW08_005319</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">EC2010</strain>
            <tissue evidence="16">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the ATPase C chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000124">
        <property type="protein sequence ID" value="RUS86914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AAN6"/>
    <dbReference type="STRING" id="188477.A0A3S1AAN6"/>
    <dbReference type="OrthoDB" id="438052at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033177">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, proton-transporting domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18182">
        <property type="entry name" value="ATP-synt_Fo_c_ATP5G3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.20.10:FF:000003">
        <property type="entry name" value="Atp synthase f complex subunit mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="ATP SYNTHASE LIPID-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031:SF0">
        <property type="entry name" value="ATPASE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 14" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="15">
        <location>
            <begin position="87"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RUS86914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="153" mass="15739" checksum="A28D9F43E48869DB" modified="2019-04-10" version="1">MYACAKFVQPSVRCLTTVSRSALRPLGSAVVAKQEQQAPAASLSNYSGISALNLTARAPNVSSLISQIRSFQTSAVQRDIDQAAKYIGAGAATVGVAGSGAGIGSVFGSLVVGYARNPSLKGQLFSLAILGFALSEAMGLLCLMMAFLLLFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AC93</accession>
    <name>A0A3S1AC93_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">xanthine dehydrogenase</fullName>
            <ecNumber evidence="4">1.17.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">EGW08_004058</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">EC2010</strain>
            <tissue evidence="22">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>hypoxanthine + NAD(+) + H2O = xanthine + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24670"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>xanthine + NAD(+) + H2O = urate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
        <text evidence="19">Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="19">Binds 2 [2Fe-2S] clusters.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the xanthine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.4" evidence="4"/>
    <dbReference type="EMBL" id="RQTK01000091">
        <property type="protein sequence ID" value="RUS88161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AC93"/>
    <dbReference type="STRING" id="188477.A0A3S1AC93"/>
    <dbReference type="OrthoDB" id="8300278at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004854">
        <property type="term" value="F:xanthine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000015">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.50:FF:000001">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase/oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000004">
        <property type="entry name" value="Xanthine dehydrogenase/oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.120">
        <property type="entry name" value="[2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.50">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.365.10">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046867">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022407">
        <property type="entry name" value="OxRdtase_Mopterin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014307">
        <property type="entry name" value="Xanthine_DH_ssu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02963">
        <property type="entry name" value="xanthine_xdhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444:SF3">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="MoCoBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20256">
        <property type="entry name" value="MoCoBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000127">
        <property type="entry name" value="Xanthine_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="CO dehydrogenase flavoprotein C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="CO dehydrogenase ISP C-domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="CO dehydrogenase molybdoprotein N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="Molybdenum cofactor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00559">
        <property type="entry name" value="MOLYBDOPTERIN_EUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 19" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="9 18" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 19" id="KW-0408">Iron</keyword>
    <keyword evidence="12 19" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 19" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="20">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="21">
        <location>
            <begin position="214"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="332"/>
            <end position="336"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="744"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="775"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="779"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="22">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="RUS88161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1038" mass="114070" checksum="83B9E87626BDAE1A" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1ACL1</accession>
    <name>A0A3S1ACL1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">H15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_003814</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the histone H1/H5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000083">
        <property type="protein sequence ID" value="RUS88418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1ACL1"/>
    <dbReference type="STRING" id="188477.A0A3S1ACL1"/>
    <dbReference type="OrthoDB" id="1110759at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031492">
        <property type="term" value="F:nucleosomal DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00073">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000140">
        <property type="entry name" value="Histone H1.0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11467:SF36">
        <property type="entry name" value="HISTONE 24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11467">
        <property type="entry name" value="HISTONE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="8">
        <location>
            <begin position="35"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="99"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="119"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS88418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="202" mass="20800" checksum="3B06AD161B44C7D6" modified="2019-04-10" version="1">MSDAVVATPAANGPKGKKAAPKAKKAASKPKVPASHPQYKIMVVAAISALKERGGSSRQAILKYIKANYKISGQDAQINAFLKKALKDGVTAGQLKQVKGTGAAGSFRLGEKKVSEKKPAKKVAKAKKPKSPSKKPAGAKKVAKPKSPAKKKPAAKKPAAKKSPAKKPAAKKPAVKKSPAKKPAAKKPAAKKSPAKKAAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AVB7</accession>
    <name>A0A3S1AVB7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fibrinogen C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_022960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001748">
        <property type="protein sequence ID" value="RUS69277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AVB7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS69277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="111" mass="12762" checksum="7F82E9503ACF28F1" modified="2019-04-10" version="1">MFSFCLCAPLSQELVNYKLLLWGTKTGNLEDGNGIGISYSNNTVFSTYDNINANRSDINCPRTLRSAWWFSQDLSCTKVNLNGNWQNGLFWEANGFNRWLNSTKMMMRRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B0L4</accession>
    <name>A0A3S1B0L4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_023273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001901">
        <property type="protein sequence ID" value="RUS68964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B0L4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS68964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="148" mass="16306" checksum="86C195021B83E06C" modified="2019-04-10" version="1">MKVLSYCKTAVFCVWVSKKCPKKANFNLTAEPALQEIFMISGSEDSAAELDNSDLDPDYDDLASRQGSGSRPRSSSSTSSGENELIIELDRSRVGKGGRKRARGRGRGSCNTTPANPRPGPSNDDWIEPDNNLAQFRMFLNLQRSVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B292</accession>
    <name>A0A3S1B292_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_018993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000960">
        <property type="protein sequence ID" value="RUS73250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B292"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS73250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="118" mass="11324" checksum="DA757375EF70D728" modified="2019-04-10" version="1">MTSVEGVSLIGASVVDSSLIGTLVVGASLKMTSIVGVSPIGTIVVGASFIMTSFVGASLIKTSFVEESVKGASLKMTSVGCVLTMGALVVGASLIMTSVVGALVAGASDVGASVGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B6U6</accession>
    <name>A0A3S1B6U6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SANT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_015863</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N-CoR nuclear receptor corepressors family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000667">
        <property type="protein sequence ID" value="RUS76383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B6U6"/>
    <dbReference type="STRING" id="188477.A0A3S1B6U6"/>
    <dbReference type="OrthoDB" id="10258692at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000012">
        <property type="entry name" value="Metastasis-associated 1 family, member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051571">
        <property type="entry name" value="N-CoR_corepressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992">
        <property type="entry name" value="NUCLEAR RECEPTOR CO-REPRESSOR RELATED NCOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992:SF39">
        <property type="entry name" value="SMRTER, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SANT" evidence="8">
        <location>
            <begin position="95"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS76383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="166" mass="19894" checksum="73E569CF2D7866BA" modified="2019-04-10" version="1" fragment="single">MREYYEKVVPEIKKLREEKESKQGTRSGQGGYVRSDAEMEQIMNGLTDQEEEEKKMRSLSVIPPMMLDARQRKMRFVNNNGLLEDPLEIHKDAQKFQTRWTDAEKQIFREKYLQTPKNFVLISSFLPQKSVADCVQFYYLNKKDENYKQLLRKQNMKRKRTMTKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B7N0</accession>
    <name>A0A3S1B7N0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_010534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000323">
        <property type="protein sequence ID" value="RUS81727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B7N0"/>
    <dbReference type="OrthoDB" id="10006218at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026913">
        <property type="entry name" value="METTL24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32026">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32026:SF10">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13383">
        <property type="entry name" value="Methyltransf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="102"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS81727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="304" mass="35590" checksum="129F5691D4B5DA59" modified="2019-04-10" version="1" fragment="single">MTSSVLKFWKLVFVFVGFLALCIFALRLSTKAQGFQRQNLEVLKFEAQEPRPQKLTWLQEKLTVGQSELNYLRKNSIPNWLRDIDIDKELNETQAVLTLHSYLDNIDVICRRKIRFGHLDDGGWEICDDIHVRPEPPCIIYSFGIANDWTFDDEVSRLYGCHVYAFDPSIEQDRHDRSKLIHFYPWGLAGITGAWPGKGWPMYTLQDIKEKLGHSDKVIDIVKMDIESSEWTALPQMVTSGQLNNVRQLLIEFHVTPGRKDVKIVQAIERLGFKKFYVHKNFHCRRRQVGFPVFRTSCYEVMYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B852</accession>
    <name>A0A3S1B852_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">procollagen-proline 3-dioxygenase</fullName>
            <ecNumber evidence="4">1.14.11.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EGW08_010133</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">EC2010</strain>
            <tissue evidence="17">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the leprecan family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.7" evidence="4"/>
    <dbReference type="EMBL" id="RQTK01000302">
        <property type="protein sequence ID" value="RUS82121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B852"/>
    <dbReference type="STRING" id="188477.A0A3S1B852"/>
    <dbReference type="OrthoDB" id="8517835at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019797">
        <property type="term" value="F:procollagen-proline 3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032963">
        <property type="term" value="P:collagen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056585">
        <property type="entry name" value="Leprecan_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039575">
        <property type="entry name" value="P3H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14049">
        <property type="entry name" value="LEPRECAN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14049:SF9">
        <property type="entry name" value="PROCOLLAGEN-PROLINE 3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23557">
        <property type="entry name" value="TPR_leprecan"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018696443" description="procollagen-proline 3-dioxygenase" evidence="15">
        <location>
            <begin position="23"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="16">
        <location>
            <begin position="479"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="29"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RUS82121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="626" mass="71795" checksum="B055F9576907E290" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B8D6</accession>
    <name>A0A3S1B8D6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_017727</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000824">
        <property type="protein sequence ID" value="RUS74520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B8D6"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS74520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="112" mass="12619" checksum="BE22EDFB1190630E" modified="2019-04-10" version="1" fragment="single">FTSIPTSAYINTNLGLHQYQPRPTSIPTSAYVNTNLGLRQYQSRPTSIPTSAYINTNLGLHQYQPRPTSIPTSAYINTNLSIHQYQPRPTSIPTSAYINTNLGLHQYQPRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B9F3</accession>
    <name>A0A3S1B9F3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Antistasin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_013273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000479">
        <property type="protein sequence ID" value="RUS78971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B9F3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018617669" description="Antistasin-like domain-containing protein" evidence="1">
        <location>
            <begin position="31"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS78971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="15759" checksum="465E06174EB9B225" modified="2019-04-10" version="1">MRPSTKMAARPVLSLLSLTLVLVLTDTALALPQLVPVGETLDPCFPIKPCKCPFGTVWSIDARGCPRCSCKPGCPPLAGCTAPTALSETPTDARSVSASLLSSLFVHPCARCTAPTALSETPTDARSVSASLQSSLSVHDRCATFIVAMATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B9S4</accession>
    <name>A0A3S1B9S4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_013030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000464">
        <property type="protein sequence ID" value="RUS79201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B9S4"/>
    <dbReference type="STRING" id="188477.A0A3S1B9S4"/>
    <dbReference type="OrthoDB" id="10059083at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47202:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47202">
        <property type="entry name" value="HISTIDINE-RICH GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS79201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="122" mass="14723" checksum="05F24F606DC3A884" modified="2019-04-10" version="1" fragment="single">VHCTTLCYIVLHCTTLYDIVLRCTTLYYIVRHCTTLYYIVLHCTILYYIVLHCTTLYYIVLHCTTLYYIVLHCTTLYYIVLHCTTLYYIVLHCTTLYYIVLHCNTLYYIVLHCTTLYYIVIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BA76</accession>
    <name>A0A3S1BA76_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_008748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000241">
        <property type="protein sequence ID" value="RUS83498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BA76"/>
    <dbReference type="OrthoDB" id="6278306at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34487">
        <property type="entry name" value="ACYL-ACP THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34487:SF1">
        <property type="entry name" value="ACYL-ACP THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS83498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="392" mass="44276" checksum="A88BEE9F4F999520" modified="2019-04-10" version="1">MEDIPSGCIDVTDLRYRSSPYPTLDCTVPGLSQEAFDRNWQPKATSLMCIDSVTRKYVIFRPLSASKSNAYTHTSTNEEREAALNSSSNTENNNPSEKVIPRAHEGKIVSSIAEMTQSKDADDNQTFIDWRRLSRERMAFGSATEFTMSRALYDPDVPKGRLDFRFTLAYVGSCTVTHRTEFFALGKGGSKVRLWSNTYQLVMVDKETRQPTKVPQWFLDEYQGRGCTNQPLVIRPFRKPSRTYCHPVLVQWSDTDEFGHATWSSYVHWAIDGLHAALLSRPTEGGSKTTDQQHQEAKSAGAVRRSDTPKRAGAVRGSNALRGITSGTLKRGLAKFQTCYFKECLEGERVEVHIWQEGEAEEVFCSILRAGEEVSQVKLVYFTDEDEEEEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BDS3</accession>
    <name>A0A3S1BDS3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Gamma-aminobutyric acid type B receptor subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EGW08_010568</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">EC2010</strain>
            <tissue evidence="15">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000325">
        <property type="protein sequence ID" value="RUS81651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BDS3"/>
    <dbReference type="STRING" id="188477.A0A3S1BDS3"/>
    <dbReference type="OrthoDB" id="2150267at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06366">
        <property type="entry name" value="PBP1_GABAb_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000063">
        <property type="entry name" value="Gamma-aminobutyric acid type B receptor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF74">
        <property type="entry name" value="GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01177">
        <property type="entry name" value="GABAB1RECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="501"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="536"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="574"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="613"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="713"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="736"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="14">
        <location>
            <begin position="569"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="928"/>
            <end position="978"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RUS81651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1088" mass="120957" checksum="8DCA364E6E937CBB" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BEI3</accession>
    <name>A0A3S1BEI3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Gamma-tubulin complex component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_005744</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000137">
        <property type="protein sequence ID" value="RUS86494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BEI3"/>
    <dbReference type="STRING" id="188477.A0A3S1BEI3"/>
    <dbReference type="OrthoDB" id="66546at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22572">
        <property type="entry name" value="GCP5_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059169">
        <property type="entry name" value="GCP5_N_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF33">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="344"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="712"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="216"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="607"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="610"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="621"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS86494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="971" mass="109841" checksum="6C40AAF3EAE154E1" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BJB2</accession>
    <name>A0A3S1BJB2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tetratricopeptide repeat protein 5 OB fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_007236</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000186">
        <property type="protein sequence ID" value="RUS84991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BJB2"/>
    <dbReference type="STRING" id="188477.A0A3S1BJB2"/>
    <dbReference type="OrthoDB" id="423589at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.550">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032076">
        <property type="entry name" value="TTC5_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038645">
        <property type="entry name" value="TTC5_OB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050498">
        <property type="entry name" value="Ycf3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44858">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44858:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE SPINDLY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16669">
        <property type="entry name" value="TTC5_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="100"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="219"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeat protein 5 OB fold" evidence="4">
        <location>
            <begin position="314"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS84991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="435" mass="47959" checksum="FB7344B8EA8AF186" modified="2019-04-10" version="1" fragment="single">AAGERVSTPTDQASAIADELYDFRDHFVERFGLERAGEKDAEVHKKMEECLQRLEEIQGDVRNKAQLQYLRGKILNVTPKYSPEAEEALGKAVKLDPRLVQAWNHLGECYWKKEDVSAAKNCFTGALNHSKNKVSLRNLSMVLRQLSGPPVEKVKLIEESIERAKEAVQLDLTDGTSWLILGNAYVCQTFSYGQNPKALKQAMQAYTQADKDTVARSNPDLHFNRAVTYKYIGEYQLALDGFSMASQLDPSWAEAKAKETELLNYLKDVQKMVGSKGKMKQKKIDSLCSSISDRDLGPYSSLEYVDAAAKTVTLSRCKLAELQPKVNAGKLVVGKVVCSVNSTDGVPFPVCIVDEDQTAVAVMINKLAQDAGMKVGDSVAIPEPCLTRVKLSHKGTEISFSSIQVDSPRLLVVNGRKLGVSKEVQPILSTRAVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BMR2</accession>
    <name>A0A3S1BMR2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_007795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000206">
        <property type="protein sequence ID" value="RUS84411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BMR2"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS84411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="122" mass="14113" checksum="99E5FC44FBE59A90" modified="2019-04-10" version="1" fragment="single">KLDNQLDNQATLDNQLDNQLDNQLHNQLDNQAKLDNQAKLDNQLDSQLDNQLDNQDKLDNQLDNQLDNQAKLDNLLDNQLDNQAKLDNQAKLDILLDNQLDNQGKFDYQLDNQAKLDYQAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BRD3</accession>
    <name>A0A3S1BRD3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibrinogen C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_002610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000051">
        <property type="protein sequence ID" value="RUS89592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BRD3"/>
    <dbReference type="OrthoDB" id="6140297at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS89592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="30960" checksum="3B99E8D6FEBF7836" modified="2019-04-10" version="1">MAANLSSYDESLAKVETIVDKWTVATTAEDATLTGLVSGVSSLYNLTLNLVSQITTLTNSYAGGALVPVEEFSDPFGIGKKEWKLVFRGTAYNNVEVYPAYLYGTGIPIEVEEGCKQFTRSLPCVNHYRNGEAFDNWVGIDEVLFAIYKDGQMVQNVLFNGKGSTYTNWFSANRVISSSWNDLTSQPHNFFSIEGYLHTSAGETRRFHINRDYDRGCDGFQGWFTVKDTVINGCAAENTVAMPMFQYAAAKTFAAWNGENVDRADAIGIFLKYEWLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BS17</accession>
    <name>A0A3S1BS17_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_002120</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000039">
        <property type="protein sequence ID" value="RUS90153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BS17"/>
    <dbReference type="STRING" id="188477.A0A3S1BS17"/>
    <dbReference type="OrthoDB" id="1724687at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000554">
        <property type="entry name" value="Ribosomal_eS7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01251">
        <property type="entry name" value="Ribosomal_S7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS90153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="121" mass="13869" checksum="0CD65C359DB99EE7" modified="2019-04-10" version="1" fragment="single">MYSANAKIIKPQGEKPDDFESSISQGLLELEMNSDLKASLYELNITGAKEIDMQGKKAIIIFVPVPQLKAYQKIQTRLVRELEKKFSGKPVVFIAQRRILPKPTRKSKRKNKQKRPRSDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BSW8</accession>
    <name>A0A3S1BSW8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_001488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000025">
        <property type="protein sequence ID" value="RUS90777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BSW8"/>
    <dbReference type="STRING" id="188477.A0A3S1BSW8"/>
    <dbReference type="OrthoDB" id="5953112at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050237">
        <property type="entry name" value="ATP-dep_AMP-bd_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43767">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43767:SF10">
        <property type="entry name" value="SURFACTIN SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS90777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="411" mass="45784" checksum="06744616D882FFE8" modified="2019-04-10" version="1">MEESSSADFDTIPKRLKCVADRYPEREIFICVGKDSRYAFTAGSLLRLAGKFATRLLDYGFKHGDVIANTLPNSPERIITDLGIILAGCVGLNGQILLADGSDFLDSAWKARCNGLILCPEEWSPTWVLLRSNIADQDARMFSPISHQQVTDMTKAVLVRSASSFSRPNDQPSFLDDLETGAETAPPLDLCQPDDVMYVLSSSGSSGFSKLIPHTHREAVVMGAPWFARSRSDQDVPKEFSARPLGPSVFTGFFNRQASPDPATSLAFTPECWYRTEDFGWFNEGGSLYVLGRARDVISRDGIHLYPGWLEAKIIQHQDILEAVILPVSDTIRHHKICAIVKTHPESTLNETELEEFSRSIFLANTRDNYVPMPDFFKILKGKDFPQTATGKPDLHSLRKIVEDQFGANTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BTV5</accession>
    <name>A0A3S1BTV5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_003716</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000080">
        <property type="protein sequence ID" value="RUS88540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BTV5"/>
    <dbReference type="STRING" id="188477.A0A3S1BTV5"/>
    <dbReference type="OrthoDB" id="77006at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="217"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS88540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="532" mass="59925" checksum="305A52D05E949F5F" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BUA0</accession>
    <name>A0A3S1BUA0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Complement C3/4/5 macroglobulin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_003321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000071">
        <property type="protein sequence ID" value="RUS88882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BUA0"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018654183" description="Complement C3/4/5 macroglobulin domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS88882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="13851" checksum="E75611DC4DB8AB39" modified="2019-04-10" version="1" fragment="single">MMDHKNHVLVCSFVPILLSLGTLSLPQQDQEGHLVTIRLVREESNPDARVRREADSNMPDKLTLQIPTEHDQVVTLNAGRVKLLSMVTRGSNVTAPYSQNVAVYTDIDHSASMIVRRAEGQYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BV73</accession>
    <name>A0A3S1BV73_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_002606</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000051">
        <property type="protein sequence ID" value="RUS89588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BV73"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS89588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="138" mass="14791" checksum="F56E1A8BD92FD23C" modified="2019-04-10" version="1" fragment="single">LHHLPAEPVWPADGEQLVELVDALQVEPAAVEGLAQGLADGAAVGLPAGQEVAPRRTLGVALGQDVKHNVVQDGLHHLQTNTYSHVHSLMSYQHLQHPQGLSTGTFPYHVHITTQIGCAHQNEALHVLLADIIDDVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BXC5</accession>
    <name>A0A3S1BXC5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">28S ribosomal protein S22, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_014907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000589">
        <property type="protein sequence ID" value="RUS77331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BXC5"/>
    <dbReference type="STRING" id="188477.A0A3S1BXC5"/>
    <dbReference type="OrthoDB" id="10052321at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019374">
        <property type="entry name" value="Ribosomal_mS22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13071">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13071:SF4">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10245">
        <property type="entry name" value="MRP-S22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS77331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="39971" checksum="364AFB7B4DBA4287" modified="2019-04-10" version="1">MAASIPFRSTSSYSTLFTRLANLKVRRRSFAHTSKALCASSEETPPSSSNSDGRDPFPVFVDNKVQHLLSNITGFDILKIAGPHKKHLEKPKYRLLTDAELKGEMTKARERLSKRLQIPPYMNPRKPNLTPLAVDPDLAQFDTSNYVFTDVTFGVKDRDRTVVIREADGTLRIAPWDVRDRMNQIYNPREGKEYLKPQMFDEQNLERMISEKKYVYILDRACCQFEPDDPDFIRTTHRVYRAIDSAGDHDDLRSTRHFGSLAFYLVWHKTADSLLLDMLNRDLSSDAADLVRLYGILHPQSACAGVLGQLSPDSGSTAVVQVYIDTSSTLTSELQLALQAMDDAGKGHRSGLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BYR1</accession>
    <name>A0A3S1BYR1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">N-terminal E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
            <ecNumber evidence="6">2.3.2.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_013842</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-N-terminal-amino acid = [E1 ubiquitin-activating enzyme]-L-cysteine + N-terminal-ubiquitinyl-[acceptor protein].</text>
            <dbReference type="EC" id="2.3.2.25"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="EC" id="2.3.2.25" evidence="6"/>
    <dbReference type="EMBL" id="RQTK01000512">
        <property type="protein sequence ID" value="RUS78394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BYR1"/>
    <dbReference type="STRING" id="188477.A0A3S1BYR1"/>
    <dbReference type="OrthoDB" id="406833at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23808">
        <property type="entry name" value="UBCc_UBE2W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000022">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="3"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS78394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="151" mass="17012" checksum="06CFAD84B8824F69" modified="2019-04-10" version="1">MTSMEKRLQKELQAMTKDPPAGVSVNTNSLSSSLSEWIVDIEGAPSTLYEGERFQLGFKFTSRYPFDSPQVMFLGPNIPVHPHVYSNGHICLSILTEDWSPALSVQSVCLSIVSMLSSCKEKKLPPDNAIYVRTCSKDPKKTRWWYHDNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C024</accession>
    <name>A0A3S1C024_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tektin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_012926</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytoskeleton</location>
            <location evidence="4">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tektin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000459">
        <property type="protein sequence ID" value="RUS79308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C024"/>
    <dbReference type="STRING" id="188477.A0A3S1C024"/>
    <dbReference type="OrthoDB" id="5788000at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048256">
        <property type="entry name" value="Tektin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000435">
        <property type="entry name" value="Tektins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960">
        <property type="entry name" value="TEKTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960:SF12">
        <property type="entry name" value="TEKTIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03148">
        <property type="entry name" value="Tektin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00511">
        <property type="entry name" value="TEKTIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="310"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="390"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS79308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="456" mass="52595" checksum="ED69F77564FED3D3" modified="2019-04-10" version="1">MAAIASEQVNPATATLASWEAPPEPPAFAVNPNPDMEMTYTGNTGNDMGISTMGFRSAKYNPSEWHETNYAKYYQSFVDRDNAERVIHESKRTEKETKETTNKTQAEATKKLAESAKNIEFWKFELNREIGDVIDETELLLAQKKRLENALRATEVPLHIATDNLNCRQRRQGLDLVQDDVEISLLKEVEIINNVQDLLKNTINQCEKQIRLNRDAKQNLEMDWSDKKEALEIETKSGSLRNHHTNKQFHDGAAKFEEIQSTPESWAQFTHDNIARAEHERMASIQLRTLVDNVLEDTSRDMREQADQVEVNFNKRLTEMEDAKVKLEENLNKVVKQITSQEKNIAELQQSIRDKEDPLKVAQTRLYNRTYRPGVELCRDPAQYHLVGEVNEIQQSVDALKQKLNDAGNSLKDLQDNRMALEKEISCKKNSIFIDREKCLTVRNRYPSRTKLQGYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C0M9</accession>
    <name>A0A3S1C0M9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_012571</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000435">
        <property type="protein sequence ID" value="RUS79687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C0M9"/>
    <dbReference type="STRING" id="188477.A0A3S1C0M9"/>
    <dbReference type="OrthoDB" id="416496at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052356">
        <property type="entry name" value="Thiol_S-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036:SF1">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase type 11" evidence="2">
        <location>
            <begin position="79"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS79687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="261" mass="30081" checksum="53F376345931BA6E" modified="2019-04-10" version="1">MAKVDANISFVIFYCVAPVLILLLTARYIFGLTLKKLESKIFEHLLSWISRRYLEKDKQLLFEPLADLKQRSRGPFSILEIGLGCGENFKFYPKGTHFSCVEPSPHHDSVWKKRLENYRHIKLVDCFHTYAESMPDVKSDSYDVVVSTLTLCTVRDPPSVLKEIHRVLKPGGSFFTMEHVAGSKGSVIRAVQDLVTMYTPYSYVTGGCKMNRETWAYLDQSGFQSVQYRQYSINTWMLFFLRPFLYGTAVKKGIEEKIKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C9C4</accession>
    <name>A0A3S1C9C4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_005743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000137">
        <property type="protein sequence ID" value="RUS86493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C9C4"/>
    <dbReference type="OrthoDB" id="10661222at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS86493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="411" mass="46031" checksum="A73412CD38308265" modified="2019-04-10" version="1" fragment="single">EESAKLAGLSAQEKQVSNLELALARSQIKDSRDKLFQDKMNEEQQSSRNAPIITEEPNKNPDGGDTGLPFIVPKRKLKQKGIDSSRSDADVSRKSKFVNALREKHKKKLENDHTTTVPPNKDLMDLMTDLKSIEEEEEGEDGEKSQAAVEDFADQKKKEKYKNVPLKNSDPGQKEGRPYQEVNPDKDKITATENTEGSNTNTEPPEAGKPPLEGPNLRGGGKAHIGYKTKAAAKEKNKGKHKKKHKSIFDKQPQLDNDAVEMAISLERQADHNHTGQFHLVNKGKDVLDIPLADTDQSWTHKFHGRRDIVAAGAIVMSLGLIVILVSLINLVRRRFINSERSKRNRNNNRRYRTMGSLSETEVLRKPHKSLFPSAVSEDDDDDDDDDDDDGDSTSSAEEVVFHKAKLNKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1CAC2</accession>
    <name>A0A3S1CAC2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Survival of motor neuron-related-splicing factor 30</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Survival motor neuron domain-containing protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Tudor domain-containing protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EGW08_004971</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">EC2010</strain>
            <tissue evidence="17">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in spliceosome assembly.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. Plays a role in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, acts as an antiviral factor that participates in the assembly of stress granules together with G3BP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Cajal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000115">
        <property type="protein sequence ID" value="RUS87291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1CAC2"/>
    <dbReference type="STRING" id="188477.A0A3S1CAC2"/>
    <dbReference type="OrthoDB" id="434939at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="UBA1_NUB1_like"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RecQ-mediated genome instability protein Rmi1, C-terminal domain"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR042470">
        <property type="entry name" value="RMI1_N_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013894">
        <property type="entry name" value="RMI1_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010304">
        <property type="entry name" value="SMN_Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13681">
        <property type="entry name" value="SURVIVAL OF MOTOR NEURON-RELATED-SPLICING FACTOR 30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13681:SF24">
        <property type="entry name" value="TUDOR DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08585">
        <property type="entry name" value="RMI1_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06003">
        <property type="entry name" value="SMN_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01161">
        <property type="entry name" value="DUF1767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF46934">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="UBA" evidence="15">
        <location>
            <begin position="243"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="16">
        <location>
            <begin position="687"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="162"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="287"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="754"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="340"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="400"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="478"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="504"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="540"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="574"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="597"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="624"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="657"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="781"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004408"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00035105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RUS87291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="822" mass="89691" checksum="D1B43607470A3DEB" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1CBM6</accession>
    <name>A0A3S1CBM6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SMP-LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_003924</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000087">
        <property type="protein sequence ID" value="RUS88286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10004596at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044233">
        <property type="term" value="C:mitochondria-associated endoplasmic reticulum membrane contact site"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
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        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="SMP_PDZD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039275">
        <property type="entry name" value="PDZD8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058801">
        <property type="entry name" value="PDZD8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21519">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21519:SF1">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26547">
        <property type="entry name" value="PDZD8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="7">
        <location>
            <begin position="109"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS88286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="341" mass="39007" checksum="4FBAF1B0985FC525" modified="2019-04-10" version="1" fragment="single">MSGEDNYTHIQCSDEDGLVLQAQCYLHGFPPTHYVLLLGAAYLEFLMDRAVLVLLSFLAGALSLLGLQAALLYKLYSRAAPQPPPQFTPADVRLPDVLKSRLGDDLRSKKEDGTWFNFFLQFMFSELQDSLQLRRFLTKKIQTEFEEILRSRSGILVDELYLRDFNLGDNFPVFMGISVDKSDVVSGVIQTLDIRARIMYDGGFQIAVDAALPFGRVAFVSVRVLKVRGLLRFRFSRHPFSHWSISFYEECKTEFGHHVSLKKLLLLQIRRLIRKKHTLPMYKMRFKPFFLPHVDTERSSGQSIRVDGVEVGHGVFEVTIKGASRLRFITKGAYFYCTASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HEJ0</accession>
    <name>A0A3S1HEJ0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_014538</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000559">
        <property type="protein sequence ID" value="RUS77702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HEJ0"/>
    <dbReference type="STRING" id="188477.A0A3S1HEJ0"/>
    <dbReference type="OrthoDB" id="6162342at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF411">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="37"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="273"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="329"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="287"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="335"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="375"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="397"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS77702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="570" mass="62862" checksum="246A70C9A15DD5F1" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HVV9</accession>
    <name>A0A3S1HVV9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alanine--glyoxylate transaminase</fullName>
            <ecNumber evidence="3">2.6.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_005128</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.44" evidence="3"/>
    <dbReference type="EMBL" id="RQTK01000119">
        <property type="protein sequence ID" value="RUS87128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HVV9"/>
    <dbReference type="STRING" id="188477.A0A3S1HVV9"/>
    <dbReference type="OrthoDB" id="7403325at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008453">
        <property type="term" value="F:alanine-glyoxylate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004760">
        <property type="term" value="F:L-serine-pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019265">
        <property type="term" value="P:glycine biosynthetic process, by transamination of glyoxylate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06451">
        <property type="entry name" value="AGAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000039">
        <property type="entry name" value="Serine--pyruvate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000027">
        <property type="entry name" value="Serine--pyruvate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152:SF40">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152">
        <property type="entry name" value="AMINOTRANSFERASE CLASS V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="9">
        <location>
            <begin position="89"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS87128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="430" mass="46817" checksum="08D738F05E0B3B90" modified="2019-04-10" version="1" fragment="single">MAPGISRPLCAQFSKCLQRQLAQGVTHKQGCLQTHLAAFSSSASRRGTVTEPDARLFKPLVVANKLLMGPGPSNAYPRVLAAQSLPLLGHLHKDFFEILDEVKAGIQYAFQTKNEWTFAVSATGMGAMETAAVNLLEIGDVALVGVNGFWGARLADIAERNGSVAKRIIKPMGQVLTLEEIEKGLKEHKPKVLFLTYGESSGGTAQPLAGVGDLCQKYGTLLMVDSVAILGGAPMFMDEWKIDVLYTGPQKVLSIPPSGSPISFSQRARDAIASRKTRVRSFYLDATELANYWGCDEGPRRYHHTVMVSCVYGLREGLAVMAEKGLEKSWAEHAACADLLYDGLDKLGLELLVQDKAIRNPCVTVIKVPEGVDWKKVADHAMENHLLEIAGGFGELAGKVWRVGVMGYNCTPEKVQKTLDVLKEALDLHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1I0G4</accession>
    <name>A0A3S1I0G4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_002494</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000048">
        <property type="protein sequence ID" value="RUS89791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1I0G4"/>
    <dbReference type="STRING" id="188477.A0A3S1I0G4"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="97"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS89791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="327" mass="35795" checksum="0B702420BB6649A4" modified="2019-04-10" version="1">METAKALWAPFANKYSIHEETYQLQLKLMELGNRPYYMIGIDEAREQSNRTAEVIQGTVDFRGVETEMTVPSPHDPSGIPVTVYKPETCADSPTIFIFFHGGGLVVGCRQNVSNSMRVIARDSGSIVVNASYRLLPNAQAPCAPFEDGIAVTRWVMANKTAVGGTISSKVGVGGESSGGHITACVTNEVMGLDFQVLVYPVADMNLSQPSVVEFESVPILDRKTILWFSENSLAHIPGHETDPRYNPMARTNTELSPPALLVLAELDPLLSCGLDYAEKLRTAGVPVQCEIVRGVPHTVFISRDVTKTVSAQIYDYIVNFIKKFTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1I3C8</accession>
    <name>A0A3S1I3C8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_000797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000011">
        <property type="protein sequence ID" value="RUS91473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1I3C8"/>
    <dbReference type="OrthoDB" id="10025474at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS91473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="603" mass="69112" checksum="7D89AC31EBA1811E" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SJJ0</accession>
    <name>A0A433SJJ0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_022971</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001753">
        <property type="protein sequence ID" value="RUS69266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SJJ0"/>
    <dbReference type="STRING" id="188477.A0A433SJJ0"/>
    <dbReference type="OrthoDB" id="6273668at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="40"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS69266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="643" mass="72697" checksum="AFECD2BAF37B07B6" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SK29</accession>
    <name>A0A433SK29_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_022776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001673">
        <property type="protein sequence ID" value="RUS69462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SK29"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS69462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="130" mass="13992" checksum="C919E9D77A6B3E0F" modified="2019-05-08" version="1" fragment="single">AGGGTSRGQKAESKNYYIVGLIIYVGGFKGWGRHFKSVSNSLPGILVGILMFALPSSMSCIRPCSGETQPEKLDVSSEKKENAVDAVADAAGDEGLRAGVWVQSVQWSLRRVLLWVVKRLVRAKDSAPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SQ30</accession>
    <name>A0A433SQ30_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_020920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001233">
        <property type="protein sequence ID" value="RUS71323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SQ30"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019250146" evidence="1">
        <location>
            <begin position="22"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS71323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="240" mass="26578" checksum="CE3E9A2AD8D4CEF4" modified="2019-05-08" version="1">MMFGAAHLLQCLTELVSISLSIRVQQSVLPIRDIRGTSGFLLFAPKDEAAKNGSVSVSVSLIVQTMRGPSRASRACHAFPTCIGFQSVKIVWSAWEESGRHPHSFHLFDKVSRERNGQDLNSGPFASEADVLPLDHRAPRRGFCVILDSLKEYHAEMGAPVCMDLRNFSLQVQGLKLSTSPFVHTCQSALVSKASCRQLESELTHTGAWETHTKALAKMWHIATAKTMSKHSYIIESWSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SQT6</accession>
    <name>A0A433SQT6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_020635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001188">
        <property type="protein sequence ID" value="RUS71608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SQT6"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS71608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="149" mass="17186" checksum="CC9EB8B863FAD036" modified="2019-05-08" version="1" fragment="single">MNVASHISVDLDLHRGIIFFVFICLQYLAVLCAPPELEMDPVTPIYGYPYFVMCTLKVDRMDKRSLARPVEFELLEKRKKCVVTDWSYCLIPPASPPLWSCGCSSRTEDGSDAIYRFYFNIQNIDDSYRAEQVKIKMGTIELIKQMTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SRD5</accession>
    <name>A0A433SRD5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Small monomeric GTPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_020417</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001153">
        <property type="protein sequence ID" value="RUS71832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SRD5"/>
    <dbReference type="STRING" id="188477.A0A433SRD5"/>
    <dbReference type="OrthoDB" id="265044at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030990">
        <property type="term" value="C:intraciliary transport particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001684">
        <property type="entry name" value="Intraflagellar transport 27 homolog (Chlamydomonas)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS71832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="21354" checksum="E97BCA1B59AA1EF2" modified="2019-05-08" version="1">MPSILRCKCIIVGDATVGKSSIAQVFHSDSSHFPKNYTMTQGVEVLVKPVNIPETTDSVEMYIYDSAGKEIFSDLVRRFWDHPSVVIVVYDCTSETSFSSVKKWLERIRLQCPNMQIPGALVANKIDLDQRRVISPKAGKELAQSNKLEYFECSAKEMQNVDTPFFYLANEFHKLYQERVELFNSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SSZ0</accession>
    <name>A0A433SSZ0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_019877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001076">
        <property type="protein sequence ID" value="RUS72361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SSZ0"/>
    <dbReference type="OrthoDB" id="9981160at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS72361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="168" mass="17634" checksum="909205D208CDE07E" modified="2019-05-08" version="1" fragment="single">MCACRSTCPTGSTQNPSTCACSCSTQCPTGQYNNPDNSCTCLCTTTNQPPQNGVCLNCPSNSRAVGSSCQCNDPNFLYNPTTNTCACRSTCPTGSIQNPSTCACSCSTQCPTGQYNQPEGNCRCLCQSTNQLPQNGVCLNCPSGSRLVGTTCQCSDPSFSYNPQTNRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SUA0</accession>
    <name>A0A433SUA0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_019371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001007">
        <property type="protein sequence ID" value="RUS72865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SUA0"/>
    <dbReference type="OrthoDB" id="6154172at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34239">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34239:SF2">
        <property type="entry name" value="TRANSPOSABLE ELEMENT P TRANSPOSASE_THAP9 CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS72865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="228" mass="24630" checksum="53D2BE31E91BE41D" modified="2019-05-08" version="1">MKSAYDHFNNEDADIQKPDRDLGEAGPSLSETGECTTAENNDTLSYFNFLTGSSAPLEIFIDADIAFGVEKVLAEGLTKDNLNTLQDKYNPPTNCSRISVLQCNPEIFKNTSQAPKTRDSALQTIQKSVTKGLTAVLLAFGGLSAIISPETSKPIKQLADGIALLAYGSHALDLHLRHAFRGELKEEYSSLCSEAHPIVCSLFGPNVQNCIKLAGSNHTIQKPVASLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SVT8</accession>
    <name>A0A433SVT8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Armadillo repeat-containing domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_018806</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000937">
        <property type="protein sequence ID" value="RUS73431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SVT8"/>
    <dbReference type="STRING" id="188477.A0A433SVT8"/>
    <dbReference type="OrthoDB" id="10017790at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006911">
        <property type="entry name" value="ARM-rpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051303">
        <property type="entry name" value="Armcx_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15712:SF23">
        <property type="entry name" value="ARMADILLO REPEAT CONTAINING 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15712">
        <property type="entry name" value="ARMADILLO REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04826">
        <property type="entry name" value="Arm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Armadillo repeat-containing" evidence="9">
        <location>
            <begin position="361"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="41"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS73431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="627" mass="67940" checksum="A7AD198305296B6F" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SWH7</accession>
    <name>A0A433SWH7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_018625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000917">
        <property type="protein sequence ID" value="RUS73619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SWH7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS73619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="105" mass="11998" checksum="ED27083A565816C0" modified="2019-05-08" version="1" fragment="single">DHTGKKKHLQNRTIVQSGNKMHTILQNRTIVQSGNKMHTILQNRTIVQSGNKMHTILQNRTIVQSGNKMHTILQNRTIVQSGNKMHTILQNRTIVQNGNKMHTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SZT9</accession>
    <name>A0A433SZT9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UBR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_017414</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000795">
        <property type="protein sequence ID" value="RUS74824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SZT9"/>
    <dbReference type="STRING" id="188477.A0A433SZT9"/>
    <dbReference type="OrthoDB" id="10262564at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15542">
        <property type="entry name" value="PHD_UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19677">
        <property type="entry name" value="UBR-box_UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040204">
        <property type="entry name" value="UBR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047506">
        <property type="entry name" value="UBR7-like_UBR-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="6">
        <location>
            <begin position="52"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="4">
        <location>
            <begin position="52"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="229"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="274"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="296"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS74824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="477" mass="54387" checksum="7B60B0BBB72C6373" modified="2019-05-08" version="1">MDQNQSNPNSSVRRCGQVGEGDDSQLTLMDALDEVERLEADADAVLGGSDAYNCTYPQGYLKRQAVYACVTCTPEGNAGICLACSYACHEGHDLLELYTKRHFKCDCGNEKFKENKCQLFKDRKELNSRNRYNQNFRGFYCTCSRPYPDEDDSVEDEMIQCIICEDWHHGRHLQTEVPDNSDYHEMICTGCMCKYPFLWAYHVQCELTSEIQPDGGEVKEDVDIINTSSELKEDEKVNKPKQSNNSSHIEGTGTKSEVGECSTSQAECNKNKPVSCVTVSSPSKRKTNTTGDEREEVPVSKKIKTEDRFLDKNDNLKPQLEEQRTAETPKTGNCECLLKTLQKRVVHQSDCAVFWSEGWRSKLCRCSECLEMYQDRNIEFLIDDSDTMQAYEAKGIEAKKNATAAEEDEAAAFASLGRVQQIEVAQGIMDFKSELNDFLKGFAEEGKVVKESDVREFFERMRERKRNRMHLPQHNCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T1V8</accession>
    <name>A0A433T1V8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_016729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000735">
        <property type="protein sequence ID" value="RUS75512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6155007at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="662"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="750"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="842"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="875"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="971"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1350"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="487"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="553"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="686"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="703"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="756"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="852"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="875"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="900"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="996"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1006"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1072"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1137"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1360"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1381"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1401"/>
            <end position="1410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS75512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1410" mass="154424" checksum="08F8E9887D4FB01A" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T6Q6</accession>
    <name>A0A433T6Q6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_014996</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000596">
        <property type="protein sequence ID" value="RUS77243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T6Q6"/>
    <dbReference type="STRING" id="188477.A0A433T6Q6"/>
    <dbReference type="OrthoDB" id="272778at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066:SF21">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="6">
        <location>
            <begin position="318"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS77243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="360" mass="40315" checksum="AB2F8562CE8692D6" modified="2019-05-08" version="1">MLALAGPAGFYGTPVTKVLLCHAVITYLLFTFPLQHFQHLFHYNQDVLQKQQLKRMFLSKIVFLDLPDLMFTSLLIYNFRIFERRFGSRKFVSHMIATAVMASILELVAFGVLNRYNIRLADMPTGLFSCVFPLYVPFYLSVPRVALTRIMGVPVTGKTLNYILGLQMVSSEVETMLVVLCAVLSGILWRANVLGLQKLLSVPPLVGSLFDHCLGRRRSVPPRGGGLFEHCLGRYLEAASAPRSSQLPMGATLELQQRERLDRIEQQMMMSALQANRRMNIGRPQPLVVNLANGPGIFGNANPNQNGEAQQDDANVLAVSEEQVQRFVEMGFSDSRARQALRTSNNNPRLATNLLLQDMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TAP7</accession>
    <name>A0A433TAP7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_013561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000496">
        <property type="protein sequence ID" value="RUS78673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TAP7"/>
    <dbReference type="OrthoDB" id="6132914at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS78673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="263" mass="30016" checksum="A6F8F705B8836D36" modified="2019-05-08" version="1">MYWQLCLRALARTIIRSDRKESTSQFRRLTVVIPAQSLDLWKFSGWLTISGLYKTQPCAESGKLLTKKNEIENFMSQLDSSSSKQVLLPAGLTQRERALYKKLVQCTGMTSIPLAEFDRLWKQKASHSRHRAGHKPVAMTMPTRGIAASHPDVRRRTRLVQSDAQEYHGEGMMGEASLVVSRDIELCLPMNRQKHAVRDVWSRITSEDVRHKTTLKKAASASNLTTQSQQAPKSLIRQENLEHSQAYRTQAKKAVSDRSYKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TB23</accession>
    <name>A0A433TB23_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Arylesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_013421</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="6">Binds 2 calcium ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the paraoxonase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000488">
        <property type="protein sequence ID" value="RUS78803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TB23"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004064">
        <property type="term" value="F:arylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002640">
        <property type="entry name" value="Arylesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051288">
        <property type="entry name" value="Serum_paraoxonase/arylesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799">
        <property type="entry name" value="PARAOXONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799:SF12">
        <property type="entry name" value="PARAOXONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01731">
        <property type="entry name" value="Arylesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602640-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602640-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS78803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="35434" checksum="C8DACA515889CF22" modified="2019-05-08" version="1">MSDGKAFISAGLAVAGTIKYAEKNNVKGRILLFDFKDPSAGVVDLEIHTDQDFTFKKFRPHGISVLEDKKKGEHLVYVISHPDGLPDVIEKFRFFPRSRQLHHLKSIPVGQHLSHPNDLALVSEDQFYITNMAAFHFFPLALVETFLPLGMGAVFFYNGSEMLQVIPGLNNPNGLFLSPNQRLLYVASFLDKTLLVYRLDPHGKGAELVQTVQLFGRGDNLHLTQSGDALLVATHPDFLQFLEHWFSLTPGEINSPSSVVRLPLDDDYLVREGNITEMFYDHGDLISGSSVAAIFDGHMLIGSVVDSLVHCELFSLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TB50</accession>
    <name>A0A433TB50_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_013501</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000492">
        <property type="protein sequence ID" value="RUS78750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TB50"/>
    <dbReference type="STRING" id="188477.A0A433TB50"/>
    <dbReference type="OrthoDB" id="6130020at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000001">
        <property type="entry name" value="Chitinase 3-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="6">
        <location>
            <begin position="1"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS78750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="353" mass="40205" checksum="7511D297FC671FF7" modified="2019-05-08" version="1" fragment="single">CYYSSFAQTREGPGNFLPEDIDPHLCTHVIFAFVDITADGTDLTPFNRNDQGPGGLYNRTLALREKNQALKVLLAVGGWQIGSKPFIPMVRTDSNRRRWVTNVITYLRRHGFDGFDVDWEFPATRGSPEDDKFKFTLLMKELFEAFAREAKETGREKLILTMATASGTFYINQSYEPSKIIRQGREYVDYMLLMTYNYHGQWERRTGHHSGLYPHRDDPQHGEMAQLYQEWSINYWLDVGIPKEKLIVGIPTYAMSFTLADQSETGVGAPAIGGGRMGKYTKETGILAYYEICENLRESGWRSVWLDEQAVPYAYGGDQWAGYENTRSVTLKAENIVTRGLAGAFVWSVEMGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TBR0</accession>
    <name>A0A433TBR0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_013192</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000475">
        <property type="protein sequence ID" value="RUS79035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TBR0"/>
    <dbReference type="STRING" id="188477.A0A433TBR0"/>
    <dbReference type="OrthoDB" id="5842105at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF3">
        <property type="entry name" value="YTH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YTH" evidence="2">
        <location>
            <begin position="238"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS79035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="637" mass="74851" checksum="7D79E81DAC1BED9E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TC67</accession>
    <name>A0A433TC67_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_013056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000466">
        <property type="protein sequence ID" value="RUS79177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TC67"/>
    <dbReference type="STRING" id="188477.A0A433TC67"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42264">
        <property type="entry name" value="EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42264:SF3">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS79177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="318" mass="35452" checksum="E70A6662ABBD9717" modified="2019-05-08" version="1">MHDCPLAPIPGPSSLDALARSEKEKLTTHAQSSPVQSTPNSHFEKITELAQDREGWTRLKSQIEEFAKMPHNKELEYDTASSETKTSLWQIYPSSTHPFLPRTCLVNNESQSEMLGCQSHRVSAWTKILTPGATYRRSITKEERYPELQACDWMQVLGCWATAFPIYVWVCVCACDMPECGVYTKTDVLHEHLYLGELGANFPSQHSPELPQPPHSYSNNNNNNNNNNNNNNNNNSSNNNNNNNNNNNNNNNNNNNSNNNNNNNNNNNNNNCSNSSNNSSNIIYRELVAADKSSGPPISAKVGDSGGKSSNPVRQAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TF13</accession>
    <name>A0A433TF13_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_012080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000408">
        <property type="protein sequence ID" value="RUS80157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TF13"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS80157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="201" mass="23165" checksum="CD93D357B15DFE63" modified="2019-05-08" version="1">MRTLLERDITNDTITVERESFYSPVKEYEVSHIQVESNITNDTITVETESFYSPVKEYEVSHIQVESTTTNDTITVGTECVYSPVKEYEVSHIQVESNITNDNTTVERESFYSPVKEYEVSHIQVESNITNDTITVERESFYSPVKEYEVSHIQVESNITNDTITVERESFYSPVKEYEVSHIQVESNITNDNISVKVVCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TK76</accession>
    <name>A0A433TK76_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_010262</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000310">
        <property type="protein sequence ID" value="RUS81993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TK76"/>
    <dbReference type="STRING" id="188477.A0A433TK76"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01408">
        <property type="entry name" value="SIRT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF7">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="5">
        <location>
            <begin position="92"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="18"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="413"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="417"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="452"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="496"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="553"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS81993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="662" mass="72129" checksum="01A794CD7A85CCA7" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TL06</accession>
    <name>A0A433TL06_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mediator of RNA polymerase II transcription subunit 31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_009957</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Mediator complex subunit 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000293">
        <property type="protein sequence ID" value="RUS82279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TL06"/>
    <dbReference type="STRING" id="188477.A0A433TL06"/>
    <dbReference type="OrthoDB" id="10257739at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1340:FF:000001">
        <property type="entry name" value="Mediator of RNA polymerase II transcription subunit 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1340">
        <property type="entry name" value="Mediator of RNA polymerase II, submodule Med31 (Soh1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038089">
        <property type="entry name" value="Med31_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008831">
        <property type="entry name" value="Mediator_Med31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13186">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05669">
        <property type="entry name" value="Med31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0010">Activator</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="119"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS82279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="141" mass="17225" checksum="9F66470E9FC98CA3" modified="2019-05-08" version="1">MDRKEKRFETEEQARNRFQIELEFVQCLANPNYLNFLAQRGIFKDSYFVNYLKYLQYWKEAKYAKFLKYPQCLHMLELLQYEHFRKELVNAQCAKFIDDQQLFNWQHYHRKRNTMLQEQAEKSQASKEQKDVKLLPAGPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TLC8</accession>
    <name>A0A433TLC8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_009879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000289">
        <property type="protein sequence ID" value="RUS82364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TLC8"/>
    <dbReference type="OrthoDB" id="10068079at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS82364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="207" mass="22266" checksum="4C214B6669B8F045" modified="2019-05-08" version="1">MPGIGFDEADMPRIRFDEANMPRIRFEDADMPSIGFDGADMPGIGFDEADMPGIGFDEADMPGIGFDEAEMPGIEFDEADMPGTGFDDVDMPGIGFEGEADIRGIGFEGEDDPHDIGFDEEDDPHDIGFDEEDDPHDIGFDEKDDPHDIGLDGKVSRDFGYNGEAPRDVVFNGQADPRDIGFDGGRTPLAPELYPGLAVPATGTPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TLH2</accession>
    <name>A0A433TLH2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_009904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000290">
        <property type="protein sequence ID" value="RUS82351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TLH2"/>
    <dbReference type="OrthoDB" id="8960888at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36162">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36162:SF12">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS82351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="142" mass="16268" checksum="FB5614ACF272259D" modified="2019-05-08" version="1" fragment="single">MVYVGLCWSMLVCVGICWSMLVYVGLCWSMLLYVGLCWLVCWSMLVSMLVYVGLCWSMLVYVGLCWSMLVYVGLCWSMLVYVGLCWSMLVYVGLCWSMLVYVGLCWSVLVCVGLCWSMLVYVGLCWSMLVYVGLYWSLLVCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TNM5</accession>
    <name>A0A433TNM5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_009074</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TAF10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000255">
        <property type="protein sequence ID" value="RUS83174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TNM5"/>
    <dbReference type="STRING" id="188477.A0A433TNM5"/>
    <dbReference type="OrthoDB" id="154356at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07982">
        <property type="entry name" value="HFD_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003923">
        <property type="entry name" value="TAF10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03540">
        <property type="entry name" value="TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017246">
        <property type="entry name" value="TFIID_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01443">
        <property type="entry name" value="TFIID30KDSUB"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS83174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="136" mass="15047" checksum="21B64BFF0D39B75F" modified="2019-05-08" version="1">MASTEDDSKQQSILQTQNSLDNQQQSVDKSAGVPLGDFVLQLEDYSPTIPDSVTGYYLNRAGFDACDPRITRLISLAAQKFISDIANDALQHSKMRSSGQSMKKHGKDKKMTLQMEDLTPALAEYGINVKKPAYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TP69</accession>
    <name>A0A433TP69_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_008845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000245">
        <property type="protein sequence ID" value="RUS83379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TP69"/>
    <dbReference type="OrthoDB" id="10663985at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="773"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="891"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="956"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="967"/>
            <end position="977"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS83379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1053" mass="114179" checksum="A2FC583DEB42C133" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TP84</accession>
    <name>A0A433TP84_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA selenocysteine-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_008888</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRM TRSPAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000247">
        <property type="protein sequence ID" value="RUS83341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TP84"/>
    <dbReference type="STRING" id="188477.A0A433TP84"/>
    <dbReference type="OrthoDB" id="446113at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12345">
        <property type="entry name" value="RRM2_SECp43_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040434">
        <property type="entry name" value="TSAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041085">
        <property type="entry name" value="TSAP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37457">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37457:SF3">
        <property type="entry name" value="TRNA SELENOCYSTEINE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17654">
        <property type="entry name" value="Trnau1ap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="8"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="102"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00033477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS83341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="295" mass="33392" checksum="37653FD260AB3CE0" modified="2019-05-08" version="1">MFNTGLSTSLWMGDLGDLDEHSIISAFAQWGEVVMNIKMMRDPNNAGSLKPGNFCFVEFPDVDSAQRVLHRLNGKYIPGKPGRRFKLNPASYGKEHELLPEFSLYVGELSWNVDDYQLYQFFQKRYKSVRGAKVVMDQNMKSKGFGFVRFSDEGEQQRALIEMQHMTGLGRRPIKVSLASIKKPNEASTSVGGPSPQGSYYAGHYSWGGYHYHFNQSYPASGPAEYGDVSSYYDTSNQPQPPLEEDDSEILEDPGLEINVGKENRDYIESSESFFISLEQSRWQPLDSIMSEIPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TQ37</accession>
    <name>A0A433TQ37_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_008557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000234">
        <property type="protein sequence ID" value="RUS83709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TQ37"/>
    <dbReference type="OrthoDB" id="6150820at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS83709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="660" mass="73030" checksum="73EFB3744858A635" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TT06</accession>
    <name>A0A433TT06_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EGW08_007523</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">EC2010</strain>
            <tissue evidence="16">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000196">
        <property type="protein sequence ID" value="RUS84695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TT06"/>
    <dbReference type="STRING" id="188477.A0A433TT06"/>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000020">
        <property type="entry name" value="Dachsous cadherin-related 1b"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000004">
        <property type="entry name" value="Protocadherin 1 gamma 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000007">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000123">
        <property type="entry name" value="Protocadherin beta 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050971">
        <property type="entry name" value="Cadherin-domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013164">
        <property type="entry name" value="Cadherin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025">
        <property type="entry name" value="DESMOGLEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025:SF31">
        <property type="entry name" value="NEURAL-CADHERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08266">
        <property type="entry name" value="Cadherin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="806"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="23"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="127"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="239"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="356"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="452"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="557"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="691"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="666"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="867"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="679"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="867"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="897"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="909"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="923"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="969"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RUS84695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="989" mass="108229" checksum="9E89F1E461871E9B" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TU30</accession>
    <name>A0A433TU30_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_007160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000183">
        <property type="protein sequence ID" value="RUS85066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="188477.A0A433TU30"/>
    <dbReference type="OrthoDB" id="2139939at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044688">
        <property type="entry name" value="SCI-1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34117">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34117:SF1">
        <property type="entry name" value="STYLE CELL-CYCLE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS85066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="141" mass="16818" checksum="82C91796F7BCCF27" modified="2019-05-08" version="1" fragment="single">MKFSRLFKRDNLHSTRRRSASCPNLAEYDGATKEVHREDSSSESESDIKDPASKVERLQAQRSIRRMRQKEKEKTENSLKNLLSMDDYLAKLSELKTWLKEEKHKEPDTMLSPKLKTHFKTFIRLWNKRKLPPKYYRTCSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TU77</accession>
    <name>A0A433TU77_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_007118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000181">
        <property type="protein sequence ID" value="RUS85113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TU77"/>
    <dbReference type="STRING" id="188477.A0A433TU77"/>
    <dbReference type="OrthoDB" id="10257471at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="743"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="615"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="754"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS85113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="772" mass="83947" checksum="39BE29B6B693922C" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TVK3</accession>
    <name>A0A433TVK3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_006658</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000165">
        <property type="protein sequence ID" value="RUS85575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TVK3"/>
    <dbReference type="STRING" id="188477.A0A433TVK3"/>
    <dbReference type="OrthoDB" id="10254686at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01177">
        <property type="entry name" value="IPT_NFkappaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000046">
        <property type="entry name" value="Nuclear factor NF-kappa-B p105 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.340">
        <property type="entry name" value="Rel homology domain (RHD), DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033926">
        <property type="entry name" value="IPT_NFkappaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000451">
        <property type="entry name" value="NFkB/Dor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030492">
        <property type="entry name" value="RHD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032397">
        <property type="entry name" value="RHD_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011539">
        <property type="entry name" value="RHD_DNA_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037059">
        <property type="entry name" value="RHD_DNA_bind_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24169:SF28">
        <property type="entry name" value="NUCLEAR FACTOR NF-KAPPA-B P110 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24169">
        <property type="entry name" value="NUCLEAR FACTOR NF-KAPPA-B PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16179">
        <property type="entry name" value="RHD_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00554">
        <property type="entry name" value="RHD_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00057">
        <property type="entry name" value="NFKBTNSCPFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01204">
        <property type="entry name" value="REL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50254">
        <property type="entry name" value="REL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHD" evidence="2">
        <location>
            <begin position="59"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="446"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="522"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="590"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS85575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="720" mass="79194" checksum="BB039EECD17A720B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TWT2</accession>
    <name>A0A433TWT2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_006153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000151">
        <property type="protein sequence ID" value="RUS86060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TWT2"/>
    <dbReference type="STRING" id="188477.A0A433TWT2"/>
    <dbReference type="OrthoDB" id="10054666at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000007">
        <property type="entry name" value="Calcium voltage-gated channel auxiliary subunit alpha2delta 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051173">
        <property type="entry name" value="Ca_channel_alpha-2/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166:SF37">
        <property type="entry name" value="STOLID, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="10"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS86060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="430" mass="49167" checksum="55FA49A3A90E269B" modified="2019-05-08" version="1" fragment="single">YIQAATAPKNILILLDSSGSMKGLRFSIARSTVSKILETLSDEDYFNVLQFSDEPQYVDECFNDTLMPASVDNVKRIQSKIDALDAQKFANFEKALTKAFELFRKEQNEYSSHYLCNKAIMLITDGAPENFDHIFDRFNWPNKTIRVFTFLIGKEVPENRQTKWMACVNKGKFTHISTRADVQENVQKYIQVLSRPLAINKAQHKVWSPVYLDYVTEQGQILVNSGKPANLGPFFEDSYTHQGLGLVLTISMPVYDRRDEVGPKEEIPQRNLLGVVGTDVRINELMKLIPTFELGVNGYAFAITNHGNIVFHPDYRPFYVESAFRAQTELKLRPKYNSVELSEVELPVPSEDGKTKAHPLRHYFVRLRSGGHNMTTIPVLTHCDGMKRAAERQQEYHFQDIENAFRLVFVSPKNHGNFRPSVPSVSDFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TXR0</accession>
    <name>A0A433TXR0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_005829</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000140">
        <property type="protein sequence ID" value="RUS86379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TXR0"/>
    <dbReference type="STRING" id="188477.A0A433TXR0"/>
    <dbReference type="OrthoDB" id="10011262at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="92"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="372"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="389"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS86379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="432" mass="47879" checksum="31662A87C0211B1C" modified="2019-05-08" version="1">MSEYDLVNSSRSTDLELAYLNIFDYPDEGSVHLDLDKDHVWGSNVSDAKTGNATTHTVTQPAEESGKPDVWYWRVGLFAAGGSGICCAGVVCNIIAIIVLLNFRKKSSAPFLLIALACLESAFLLSYLFLENIALLSWGGLITAAYVENIKRTYSNYSWTLINTLHSLTSFSHPHRPHHPTTCPSVLYPLPHIFQTSLAYLVVVITLERYVVVAWPFRARDLCRTEFGNSCFYNTIFIRRMHLIFNFGVPSLLLLVFNTLLVLALRRSAFSGSAHDESRAAREKRLTLMVFSMTAIFLVVQLMEGVALTMLAGLSQYEDAPMAVNRFSAVADTLMLLNSATNFAIYCATGRQFRETFVRLFCYSCRHGKDRAGTPMDGKQNGQHRCATPSRTNATKITSPAKSSAPVTTLTTHSYDMGKDENTGNLVSTTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U001</accession>
    <name>A0A433U001_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_005091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000118">
        <property type="protein sequence ID" value="RUS87159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U001"/>
    <dbReference type="STRING" id="188477.A0A433U001"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS87159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="18187" checksum="6912DBDA20403549" modified="2019-05-08" version="1" fragment="single">TIYLSIYLSIYLSIYLSIYLSIYLSIYLLSLTIYLSIYLSIYLSIYLSIYLSIYLSIYLKNVSNQFIRLSIFISIYLSIYLSIYLSIYLSIYLSIYLHIYLSSCLSIYLSIYLSIYLSIFISIYLSIYLSIYLSIYLSIYQSIYLSIYLSIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U166</accession>
    <name>A0A433U166_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_004722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000108">
        <property type="protein sequence ID" value="RUS87546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U166"/>
    <dbReference type="OrthoDB" id="7765170at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="118"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS87546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="208" mass="23654" checksum="094EF128C5586A99" modified="2019-05-08" version="1" fragment="single">ICMRFLLDLSSVRIRHKLAQAKTYLRVMENPHHPLYPSLLTQKGTRIKRGKSWMAEAEDSIKLVCPIEDIIDGREWIKTGPEQTALTKVIITMGRDRRECAAAVTEQDIRQLIHDNSKRHDPIIYTDGSVKRGIQSGWGFVCYSENRVIHEESGAAATTTSSMKMEIEAITKALEWIKLTRPTTTHAVFLTDSQSALKKIECGFMRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U1K1</accession>
    <name>A0A433U1K1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Polycystin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_004550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polycystin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000103">
        <property type="protein sequence ID" value="RUS87709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U1K1"/>
    <dbReference type="OrthoDB" id="2121937at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050982">
        <property type="term" value="P:detection of mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051223">
        <property type="entry name" value="Polycystin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046791">
        <property type="entry name" value="Polycystin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877:SF194">
        <property type="entry name" value="LOCATION OF VULVA DEFECTIVE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877">
        <property type="entry name" value="POLYCYSTIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20519">
        <property type="entry name" value="Polycystin_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Polycystin" evidence="6">
        <location>
            <begin position="3"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS87709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="165" mass="19220" checksum="9F454C5E8503AEBC" modified="2019-05-08" version="1" fragment="single">DLCYPVPNSGIDIKRSCNFEFTSSTADDQDYAGSWLIPGANGTDEDSYKNYKYKTREKSVFEAADFLPANGYWRVFHFDNVMTPEELQELATSDWVDEHTRYLRIEFSVINPGSSITSTFRTTVDFKRPAVFWSTEGHTFRHQQSESRTYVFYMLQVIFITLTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U3E6</accession>
    <name>A0A433U3E6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_003869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000085">
        <property type="protein sequence ID" value="RUS88357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U3E6"/>
    <dbReference type="STRING" id="188477.A0A433U3E6"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS88357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="114" mass="14533" checksum="8395655D127E43F9" modified="2019-05-08" version="1" fragment="single">FSNKFHQQFSNKFHQQFSNKFHQQFSNKFHQQFSNKFHQQFSNKFHQQFSNKFHQQFSNKFHQQFSNKFHQQFSNKFHQQFSNKFHQQFSNKFHQQFSNKFHQYFSNKWIHTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U5D3</accession>
    <name>A0A433U5D3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_003198</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Deltex family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="RQTK01000068">
        <property type="protein sequence ID" value="RUS89027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U5D3"/>
    <dbReference type="STRING" id="188477.A0A433U5D3"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09633">
        <property type="entry name" value="Deltex_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02907">
        <property type="entry name" value="Macro_Af1521_BAL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039396">
        <property type="entry name" value="Deltex_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039399">
        <property type="entry name" value="Deltex_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039398">
        <property type="entry name" value="Deltex_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12622">
        <property type="entry name" value="DELTEX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18102">
        <property type="entry name" value="DTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019105805" description="RING-type E3 ubiquitin transferase" evidence="11">
        <location>
            <begin position="18"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="domain" description="Macro" evidence="13">
        <location>
            <begin position="571"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="1044"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="135"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="487"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="793"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="244"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="333"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="510"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="798"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="813"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS89027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1247" mass="140041" checksum="D63B50CA75BD1BE1" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U865</accession>
    <name>A0A433U865_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CSN12-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_002264</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000043">
        <property type="protein sequence ID" value="RUS89997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U865"/>
    <dbReference type="STRING" id="188477.A0A433U865"/>
    <dbReference type="OrthoDB" id="10252687at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000146">
        <property type="entry name" value="PCI domain-containing protein 2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF0">
        <property type="entry name" value="PCI DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="210"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00033214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS89997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="400" mass="46357" checksum="B20C94F7B6FF6D19" modified="2019-05-08" version="1">MANISLNSYLHVVNEALQNYDSDEAARWLSFRDAHVASHQLQNLRPDQHCRRVLDPPYDEMVAAHIKCCYYVANHDFVEAYDQQAQVAQCFVKALQSHKEENWALPVMFAVALDLRLFAVNADIQLVQRNKGKAGESLEKAAEQLMGLFRVCASDNRAAIEDSKKWGMLNLVNQLFKIYFKINKLHLCKPLIRAIESLPIKDKFSLSQLVTYRFYVGRKAMFDSDYKSAEEYLKFAFEKCHRDSHKNKRLILIYLIPVKMLLGSMPKTGLVRKYDLRQFLDVAQAVRSGNLLQLNEAMQKHEAFFIRCGIYLILEKLKILTYRNLFKKVYLIKDKNHLVDISSFTVALRMMGVEDIDDDETQCLLANLIYENKIKGYITHQHQKLVVSKQNPFPVLSQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U9V0</accession>
    <name>A0A433U9V0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_001611</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000028">
        <property type="protein sequence ID" value="RUS90614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U9V0"/>
    <dbReference type="STRING" id="188477.A0A433U9V0"/>
    <dbReference type="OrthoDB" id="1882297at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3250:FF:000001">
        <property type="entry name" value="60S ribosomal protein L13a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS90614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="217" mass="24860" checksum="872EA1BF1693B316" modified="2019-05-08" version="1" fragment="single">CSFCPALPDDLRNWPYFSFHYFISGPPCRPQKKPNTSVHCVQPSSFFNKMGFSSQPIVIDGRGHLLGRLASIVAKTLLNGQRVVVVRCEGINISGNFYRNKRMLPHKTTRGKEALARLKVFEGVPAPYDKKKRMVVPSALKVLRLNPTRKFCSLDRLSHEVGWKYQGVVATLEAKRKVKSKHFYDRKKQLTFLREQAKKNVASKIQPYQQTMSQMGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UAG4</accession>
    <name>A0A433UAG4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Leucine carboxyl methyltransferase 1</fullName>
            <ecNumber evidence="7">2.1.1.233</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_001443</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine = [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:48544"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="2.1.1.233"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the methyltransferase superfamily. LCMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.233" evidence="7"/>
    <dbReference type="EMBL" id="RQTK01000024">
        <property type="protein sequence ID" value="RUS90824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UAG4"/>
    <dbReference type="STRING" id="188477.A0A433UAG4"/>
    <dbReference type="OrthoDB" id="203237at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018423">
        <property type="term" value="F:protein C-terminal leucine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000092">
        <property type="entry name" value="Leucine carboxyl methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016651">
        <property type="entry name" value="LCMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600:SF33">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016305">
        <property type="entry name" value="LCM_mtfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="150"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR016305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR016305-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS90824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="314" mass="35555" checksum="6DFD5F458041B9A2" modified="2019-05-08" version="1">MSADPGVIGTNDDASSCKRFAVDKGYWSDPYISLFMQKLPSRKAPEISRGYYARVTSIQIIIEKFLQMTQNNCQIVSFGAGFDTLYWRLFDKGLTPKKFVEVDFEQVTTRKCHFIKSKKQLLDALTCEETDIMISKNELHSAKYHLVCANIANTAQLESKLTASGIDRSLPTLFLSECVLVYVDVEGSNKLLKWISDNFPTALFLNYEQINMTDAFGQVMIENLKARDCVLSGAAACANVNTQMDRFLNNGWSGADCLDMSTVYKCLPQSDLQRIERIEMLDERELLDQLLYHYCLAWAYKDTADLGLHTISIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UDZ4</accession>
    <name>A0A433UDZ4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_000013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000001">
        <property type="protein sequence ID" value="RUS92160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UDZ4"/>
    <dbReference type="OrthoDB" id="10046645at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.437.10">
        <property type="entry name" value="Blc2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036834">
        <property type="entry name" value="Bcl-2-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56854">
        <property type="entry name" value="Bcl-2 inhibitors of programmed cell death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS92160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="665" mass="73941" checksum="6DF56BC86623F88B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UE07</accession>
    <name>A0A433UE07_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EGW08_000269</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">EC2010</strain>
            <tissue evidence="16">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000003">
        <property type="protein sequence ID" value="RUS92056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="6145378at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000020">
        <property type="entry name" value="Dachsous cadherin-related 1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000092">
        <property type="entry name" value="Protocadherin 8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000007">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013164">
        <property type="entry name" value="Cadherin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF423">
        <property type="entry name" value="PROTOCADHERIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08266">
        <property type="entry name" value="Cadherin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019163861" description="Cadherin domain-containing protein" evidence="14">
        <location>
            <begin position="23"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="796"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="31"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="136"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="246"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="358"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="471"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="576"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="692"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="832"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1116"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1216"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1289"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1229"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1292"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1312"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1345"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RUS92056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1404" mass="153172" checksum="418450F25A01F784" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UEB5</accession>
    <name>A0A433UEB5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transportin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_000009</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Importin, which transports target proteins into the nucleus. Specifically mediates the nuclear import of splicing factor serine/arginine (SR) proteins, such as RBM4, SFRS1 and SFRS2, by recognizing phosphorylated SR domains. Also mediates the nuclear import of serine/arginine (SR) protein CPSF6, independently of CPSF6 phosphorylation. The nuclear import process is regulated by the small GTPase Ran that partitions between cytoplasm and nucleus in the predominantly GDP- and GTP-bound form, respectively. Importin associates with target cargo proteins in the cytoplasm, and the competitive binding of GTP-bound Ran induces the release of cargos in the nucleus.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with (GTP-bound) Ran. Interacts with (phosphorylated) SFRS1 and SFRS2; leading to their nuclear import. Interacts with NUP62. Interacts with RBM4. Interacts with CPSF6, promoting its nuclear import.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000001">
        <property type="protein sequence ID" value="RUS92156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UEB5"/>
    <dbReference type="STRING" id="188477.A0A433UEB5"/>
    <dbReference type="OrthoDB" id="435593at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000079">
        <property type="entry name" value="transportin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057941">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057942">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058537">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF42">
        <property type="entry name" value="TRANSPORTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24138">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24140">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24139">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="12">
        <location>
            <begin position="33"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS92156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="933" mass="104169" checksum="C46943C5AD6EB33E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z4Q7</accession>
    <name>A0A3S0Z4Q7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_022895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001719">
        <property type="protein sequence ID" value="RUS69342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z4Q7"/>
    <dbReference type="OrthoDB" id="10059790at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS69342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="421" mass="48839" checksum="97D43ECF2CD3D3E7" modified="2019-04-10" version="1">MFTDLLCKKRQFLQNSLSLRNLSAIILTQTYSENPLELWLECQGDMSEDFVHNLGDPAETAHNMALIEIEDLLFSIDGSRMESYGLPVPDRDAAQSLGQEYTREISCDREQQQQTANQSIHQLTPEQRHIFDDLTNLETTLVDYRTLNSSLKVPLNVAHSRIPMCSFKKFSSHYDLALRGGTEGAADVLVIGHSRWPPAHGDSTLDLHTRCFQSRYEAEDVQRRKQLSTAALAKLQNVWVRGDKLKKETKLKLYRALVKSVLTYNCSTWALTQAEEKKLDAFHRKQLKRVVGIRYPVKITNKALYKQCNERPLSLYVLENRWRFFGHILRRDREIPANKAMEGFFVPQGDKYRGRPITTLPVVLNNDLSRLESRNYCLKTFKDIENLKKIAEQRDQWRILCTRIQKEAEALQSDDYDAERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z7C9</accession>
    <name>A0A3S0Z7C9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ISXO2-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_021202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001283">
        <property type="protein sequence ID" value="RUS71031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z7C9"/>
    <dbReference type="STRING" id="188477.A0A3S0Z7C9"/>
    <dbReference type="OrthoDB" id="6145479at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053164">
        <property type="entry name" value="IS1016-like_transposase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024445">
        <property type="entry name" value="Tnp_ISXO2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033547">
        <property type="entry name" value="transpos_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163">
        <property type="entry name" value="DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163:SF2">
        <property type="entry name" value="SI:DKEY-17M8.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12762">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01126">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ISXO2-like transposase" evidence="2">
        <location>
            <begin position="56"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS71031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="247" mass="28542" checksum="239A033E0B704CAF" modified="2019-04-10" version="1">MLLTKDLSRVPAVKHGRATEAVAIQAWEQATRLHTIVDWRSFCSEVTNEWYRKQAQIGGPDVVVEIDETLITRRKYNRGRLSTQIWPFGGIERVSKRKFLVPLTCDVAENRTKETLLPLITKYILPGTIIYSDAFRSYHDIKNLGYTHCVVNHSKNFVDPEDNNFHTQNIERLWKDVKSWVKRPGIWSKYLYQYLGRYLFPTAHEPSTLLHHFFVQAAKLYPPQSDRSPTASTELSDSSSEIDSDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z9Z4</accession>
    <name>A0A3S0Z9Z4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_019306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000999">
        <property type="protein sequence ID" value="RUS72933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z9Z4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS72933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="278" mass="31489" checksum="AA2B8D8F5D644AEE" modified="2019-04-10" version="1">MRPLSRLNTTTLATELDHTRDSTRPLPRLDHSLYSRPLSRPLSRLNTTTLATQLDHSPDSTSLATLDHTRDSTLSLLSTTLSTIRPLSRLNTTTLATQLDHSPDSTSLATLDHTRDSTRPHSQLNPTTLATRPHSDSTRPLLQLDHTRDSTRPLPRLDHSRDFRPHSQPNTTILDHTRPPRPHLRLNTTLLRDSTTLVTRPLSRLHHSCDLTTLAIQLDHSATRPLSRFNSTTPRLDHFRDSRPHSRLNTTTLNHTRPPRPHSRLNTTLLRDSTTLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZI03</accession>
    <name>A0A3S0ZI03_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mediator of RNA polymerase II transcription subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mediator complex subunit 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED9</name>
        <name evidence="9" type="ORF">EGW08_012914</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000458">
        <property type="protein sequence ID" value="RUS79329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZI03"/>
    <dbReference type="STRING" id="188477.A0A3S0ZI03"/>
    <dbReference type="OrthoDB" id="5950777at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011425">
        <property type="entry name" value="Med9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039242">
        <property type="entry name" value="MED9_metazoa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20844:SF0">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20844">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION, SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07544">
        <property type="entry name" value="Med9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 8" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS79329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="106" mass="12076" checksum="7395238FE445B36E" modified="2019-04-10" version="1">MAAAAASENELNILPYVYEVMKSIEKDTNDVMQTMNELRAQFQKARECIDQLPGTQHSQEEQLRLKSILHQQLMIKTKLLMTYKSGHHFELEPKKNGDISTGGSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZI78</accession>
    <name>A0A3S0ZI78_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_012750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000448">
        <property type="protein sequence ID" value="RUS79482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZI78"/>
    <dbReference type="STRING" id="188477.A0A3S0ZI78"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053110">
        <property type="entry name" value="Ribosomal_L1-TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48162:SF1">
        <property type="entry name" value="RIBOSOMAL L1 DOMAIN-CONTAINING PROTEIN CG13096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48162">
        <property type="entry name" value="YALI0A06930P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS79482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="282" mass="30074" checksum="167CF9724DD642EE" modified="2019-04-10" version="1">MGGVDGDDDDGGDGGVDDDGDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDNDASVIATMKLLQMLVVLNAFLVVIDDNDITVGAVDDGSGKRCCCSVDDNDITVGAVDCIRVKRYFSVVVSNNEITADAGSAKRYFSVVIDDNDITAGAVDDGSGTLVCGGDAGAKGHCGKGSTSGTGMQPMKTRIVWARPEDDRNPGVLGPSVPGEFERLAFCLASGATSVLTHDRGRSLERHNKEEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZIE8</accession>
    <name>A0A3S0ZIE8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_013749</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000506">
        <property type="protein sequence ID" value="RUS78502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZIE8"/>
    <dbReference type="STRING" id="188477.A0A3S0ZIE8"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000036">
        <property type="entry name" value="CYtochrome P450 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF375">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS78502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="484" mass="54534" checksum="125A906A0463C2FE" modified="2019-04-10" version="1">MPQLSGSAKIQGLWSSTKLRHAAARNLYYLVHRRSHLARMLLFLPPTQKKRIYFGSTLVVVVSGFRSFKEVFVHKGAVTSDRPRMFMNEAIGMGETGVVFASGSIWKELRSATLQILKEFGMGTNWLAERVQDEVACYMDKLVKTRGEPINLQHFTRVSVSNVISSIIVGKRFSHEDPRYKETVESLMRVAESSRGATAINFLPFLKYIPGDLFKAKQIQFNMTVIKDLLVQIVSETESTTASGSAKDKGGNFIFSYRRKESEKKLAGKRTCLDDDNMIKTIVDLYAAGTETVSSTIVWCVLFILHSPDVQSKIHDELDFKVGQGRPLTIEDQARLPYLGAVIKETQRLASTVPFSLLHKTREEITLGKFVIPEGTILIPNLDSVLHDPEIWGSDAEKFNPERFLDKDGALIHREEFIPFSIGPRVCLGEALGKMELFLFLSSMFQRFQFVPTDPLKLPMLKPVIGITSVPTSFEVLCVDRFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZIW3</accession>
    <name>A0A3S0ZIW3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fukutin-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_012244</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000417">
        <property type="protein sequence ID" value="RUS79979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZIW3"/>
    <dbReference type="STRING" id="188477.A0A3S0ZIW3"/>
    <dbReference type="OrthoDB" id="444255at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055105">
        <property type="entry name" value="FKRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052613">
        <property type="entry name" value="LicD_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13627">
        <property type="entry name" value="FUKUTIN RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13627:SF31">
        <property type="entry name" value="RIBITOL 5-PHOSPHATE TRANSFERASE FKRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22921">
        <property type="entry name" value="FKRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="FKRP stem" evidence="3">
        <location>
            <begin position="50"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="2">
        <location>
            <begin position="346"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS79979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="57978" checksum="DFEB9344E94C5179" modified="2019-04-10" version="1">MAFSRKLCRRKGICSILLTMLIMFFFYLFKTLPDENPSDVIHQSNIKAFNKENMPETISIILLDFEDFDNALVKTTDALHSVLGRVPIFIVSNHLMYPPVEIDPDSNVRIINLEADLTSNYSSGDVSHLIRTEFVLILPDASSLESANQIKSFIAFLNFKKATKAVAIPQVDESLYCTNFSVDLKRWSITYGKDYLRNPVNCPLVKGTHGLLMRTQTLQSLPLPFMRPFPLTFYVQAKVKGWKIRVMKSGRIGVISKLYTDPHSKWKRKTSEADHLKTFYKSVGIRQETLPSGISQYYGCDRHTPRCFGTVVKDMPEYLYRGRWTPPCCLKGLRETAVHVFSVLEKCDVRYWLEGGSLLGAVRLGDIIPWDYDVDIGIYKEDIVKCRHLRHASEGSEPFVDDQDFLWERASEGDFLRVQYSEINHLHVDIFPFYSKNGVMTKDSWFATHRQDVEFSEKFLKPLTKINFTGTLVSAPNNVKKFLEYKFGEGVVENPRYPNLKRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZMB5</accession>
    <name>A0A3S0ZMB5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EGW08_009885</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">EC2010</strain>
            <tissue evidence="15">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000289">
        <property type="protein sequence ID" value="RUS82370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZMB5"/>
    <dbReference type="STRING" id="188477.A0A3S0ZMB5"/>
    <dbReference type="OrthoDB" id="6160250at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050332">
        <property type="entry name" value="GPCR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620:SF42">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR SEB-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02793">
        <property type="entry name" value="HRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00649">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="13">
        <location>
            <begin position="16"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="14">
        <location>
            <begin position="107"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="388"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RUS82370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="458" mass="51975" checksum="C3CE2F30B2EC3285" modified="2019-04-10" version="1" fragment="single">DTCARWKSCCRDARACCRRQLQSPPGHSGQNGSCPRTWDGYGCWDDSPPGATVYIGCPSFLEHSESSRYAMKQCNADGRWFMLQNQTRENEWTDYTKCYDKESLLVSIYVGLACNIASIVLLVPAITIFMVYRSLRRQHRIRLHINFFGSLLFADVINILWEMLVSHDQLQETRNFNLGVIANCLFTLLSLYISLSLCFSTYIYINLPLSTYVSLSYPLSISLIFLFIFLFLSFALFLLFLFKSSLSLSFSLSLSLSLSLSLSHSLPNLPPPPCFLHQINFVFLFNILRILLTQLKSHPNEPSNFRRALKATFVLIPLFGVQMFVTVYRLPAGTAFAMVYEKFTAFVLNSQGFFVALIFCFFNGEVITHMNRTCTRLRLLRPPTESLRGQTTATSVHFGQPGQDSNESENGILVNGSPRPSPASGKKQYNSMELNERRYPYIPLAVRNPSQSPSPTEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZN81</accession>
    <name>A0A3S0ZN81_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_013355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000484">
        <property type="protein sequence ID" value="RUS78880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZN81"/>
    <dbReference type="OrthoDB" id="5985715at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="78"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="176"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS78880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="320" mass="36926" checksum="029343697D9D7172" modified="2019-04-10" version="1">MEKRVVEQMMLNKENGDQKSSGPGDWVKDLFAPIFDFDAIIAAGKQGSGLDKPHIKRASILDPQAVREVFERVHQRIVESERLKQEELEEKRQKDEDKKLDPRKSSIWDTEELETLRKVYKSAKGEISRLEAELRESKKHSRSLETELTAQRGQVDILASRLAEAVKSNQRLVIHRDSLQQQVAVMEVKVAALTDMWHEIDALKLQAMEETKAARIALDSERLDHQKLQCDLAEFRRNSEHNQKLVERDIQTRYEIEVNDLQDVVKDLTLELQKEKQQHEATKRGLDHLRLHFSSLPLREVLPPGAVEADQVGRVDHCDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZR88</accession>
    <name>A0A3S0ZR88_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Attacin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_011332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000367">
        <property type="protein sequence ID" value="RUS80896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZR88"/>
    <dbReference type="OrthoDB" id="10505590at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018784853" description="Attacin C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS80896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="13852" checksum="F13D4AB096701552" modified="2019-04-10" version="1">MGTLTIACIAVLVAVTSAQVALEDGDMRRGLGEPSQALRKRQSKFDLGINKSPYGVSGTAGVSHTTTGGHKFGGSVTHNVGGSTSGRLDYSKSFANGRGSIGAHVNQDFNTGHRSYGVGVGWNFKRGIRGEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZUQ4</accession>
    <name>A0A3S0ZUQ4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_005014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000117">
        <property type="protein sequence ID" value="RUS87174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZUQ4"/>
    <dbReference type="OrthoDB" id="10519124at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018629443" evidence="2">
        <location>
            <begin position="24"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS87174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="161" mass="16303" checksum="4D16515B7EDA2CEF" modified="2019-04-10" version="1">MAFLHSALHISSVLAVLCSVVLSQAPPTDPALFANLFMSSPQAGGASSNMINPGPSATDLSALVGGSQPFASSASGGSLPPDPMFPTLGGSPLGSMPPASAPKPAPNPMSQIMNMMLFRKMDMGNIWPLFAFSGMGAGAGGGSGGMFSNPLVMYSMFNNMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZX87</accession>
    <name>A0A3S0ZX87_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Liprin-beta-1/2 coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_014747</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000576">
        <property type="protein sequence ID" value="RUS77500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZX87"/>
    <dbReference type="STRING" id="188477.A0A3S0ZX87"/>
    <dbReference type="OrthoDB" id="6516566at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048786">
        <property type="term" value="C:presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007528">
        <property type="term" value="P:neuromuscular junction development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058914">
        <property type="entry name" value="LIPB1/2_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029515">
        <property type="entry name" value="Liprin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12587:SF14">
        <property type="entry name" value="AT31531P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12587">
        <property type="entry name" value="LAR INTERACTING PROTEIN LIP -RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26022">
        <property type="entry name" value="CC_Liprin_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Liprin-beta-1/2 coiled-coil" evidence="3">
        <location>
            <begin position="130"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS77500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="206" mass="22691" checksum="503C2A8C04E7B6D9" modified="2019-04-10" version="1">MSDSQDSNSDPDTRSVVAGNSNGGGGGFWYGSVTLQIKYDVVVNLETLETLLTPVLGGETHDEGQVTGRSLQTDERIRRLEDDKQSLALQSTLYHSSQPLPPRERFGGGGAGDWGIESQLVTGRSLQTDERIRRLEDDKQSLALQVSVLSEQVEAQAEKIREMESCSDDHRQRLSDANKVLQKGLFSQLPVCVCCVKLVLEKEERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZZL9</accession>
    <name>A0A3S0ZZL9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_001576</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000027">
        <property type="protein sequence ID" value="RUS90676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZZL9"/>
    <dbReference type="STRING" id="188477.A0A3S0ZZL9"/>
    <dbReference type="OrthoDB" id="5547497at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="3"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS90676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="320" mass="35245" checksum="8840359891A3F20C" modified="2019-04-10" version="1" fragment="single">VFVNKYLLSSEDLKLDAPLFVTWFQCAVTVVLCVLLSVGSQLFPGYVSFPALKFDPKVMRDTLPLSIVFVCMITFNNLCLKYIGVAFYFVGRSLTTVFNVIFTYILLQQTTSARALLCCGIIIAGFFLGVNQEGASGSLSIIGVVFGVMASASVALNAIFTKKILPLVDNNVWRLTLYNNINATFLFLPLMAIFGEAKTIFEFPLLSSVTFWNWMIISGIFGFAIGYVTGLQIQVTSPLTHNISGTAKACAQTVLACMYFREEKTSLWWLSNLVVLAGSGSYTEVKRQEMKQQHRQDVAAAEKQGEILDAIEAKKGPPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A545</accession>
    <name>A0A3S1A545_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_009275</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000264">
        <property type="protein sequence ID" value="RUS82938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A545"/>
    <dbReference type="STRING" id="188477.A0A3S1A545"/>
    <dbReference type="OrthoDB" id="5204190at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22396">
        <property type="entry name" value="KH-I_FUBP_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22397">
        <property type="entry name" value="KH-I_FUBP_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22398">
        <property type="entry name" value="KH-I_FUBP_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22399">
        <property type="entry name" value="KH-I_FUBP_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000007">
        <property type="entry name" value="far upstream element-binding protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015096">
        <property type="entry name" value="FUBP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09005">
        <property type="entry name" value="FUBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="6">
        <location>
            <begin position="122"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="6">
        <location>
            <begin position="212"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="6">
        <location>
            <begin position="315"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="6">
        <location>
            <begin position="437"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="30"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="403"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="507"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="615"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="518"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="553"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="582"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="615"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS82938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="708" mass="73964" checksum="46DCAC28C82B2DC6" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A8H3</accession>
    <name>A0A3S1A8H3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RFX-type winged-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_006874</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000173">
        <property type="protein sequence ID" value="RUS85331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A8H3"/>
    <dbReference type="STRING" id="188477.A0A3S1A8H3"/>
    <dbReference type="OrthoDB" id="10069709at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000422">
        <property type="entry name" value="DNA-binding protein RFX7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039779">
        <property type="entry name" value="RFX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619">
        <property type="entry name" value="RFX TRANSCRIPTION FACTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619:SF21">
        <property type="entry name" value="RFX-TYPE WINGED-HELIX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02257">
        <property type="entry name" value="RFX_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="2">
        <location>
            <begin position="53"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS85331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="117" mass="13337" checksum="104B393358FAD3EF" modified="2019-04-10" version="1" fragment="single">MDGTLTVQCLLKQVAELSDQDRISFLMKLPTEINQDDLDKDTPSSMSRRSKAAVSWLQCKYEENNSTSIHKQDIYEHYMEDCATTGQLPISGTNFGKIIKMVFPSIYNRRLGQRGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A915</accession>
    <name>A0A3S1A915_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_006459</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000160">
        <property type="protein sequence ID" value="RUS85745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A915"/>
    <dbReference type="STRING" id="188477.A0A3S1A915"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09823">
        <property type="entry name" value="peroxinectin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.640.10:FF:000003">
        <property type="entry name" value="chorion peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF4">
        <property type="entry name" value="CHORION PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS85745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="564" mass="62424" checksum="3A2281C9581E485A" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AA16</accession>
    <name>A0A3S1AA16_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Neurotransmitter-gated ion-channel ligand-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">EGW08_005785</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">EC2010</strain>
            <tissue evidence="19">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Synaptic cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000138">
        <property type="protein sequence ID" value="RUS86470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AA16"/>
    <dbReference type="STRING" id="188477.A0A3S1AA16"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18997">
        <property type="entry name" value="LGIC_ECD_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000043">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000016">
        <property type="entry name" value="Nicotinic acetylcholine receptor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 15" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5022253254" description="Neurotransmitter-gated ion-channel ligand-binding domain-containing protein" evidence="15">
        <location>
            <begin position="24"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="614"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="17">
        <location>
            <begin position="45"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="18">
        <location>
            <begin position="258"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="380"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="503"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="380"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="415"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="478"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="512"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RUS86470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="645" mass="72733" checksum="2F4D0D17DF974F72" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1ABA9</accession>
    <name>A0A3S1ABA9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ShKT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_004840</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000112">
        <property type="protein sequence ID" value="RUS87386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1ABA9"/>
    <dbReference type="STRING" id="188477.A0A3S1ABA9"/>
    <dbReference type="OrthoDB" id="6134424at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052660">
        <property type="entry name" value="Erythrocyte_Invasion_ImmMod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16021:SF13">
        <property type="entry name" value="ETS DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16021">
        <property type="entry name" value="MANSC DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="396"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="229"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="401"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS87386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="627" mass="68256" checksum="32FE6EFC18A562E2" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1ABJ1</accession>
    <name>A0A3S1ABJ1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_004680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000107">
        <property type="protein sequence ID" value="RUS87574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1ABJ1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS87574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="381" mass="41937" checksum="56A60290E5C73AEF" modified="2019-04-10" version="1">MARHDRPEIAGSSATLAGAAVSTAFSCCYLLTALLHAGPFQGEGSPKFVSHYRANAPPRPRRSTGHRESKEHCRTRQLTRGLLAHTTSAHQRPCDAHTQRQFTRGLVTHTHNVSSPEALWPTYTQRLLTRGLVAHLHTASAHQRPCGPLTHSVSSPEARGPHTQRELTRGLVTHTHNVRSPEALWPTYTQRQLTRGLVAHTHIHTHNVSSPEALWPTHTQRQLTRGFVTHTHTTSARGRPPLGITSQSSTPPKKKQDDGNPLTSVQSIPGALWRCNRCYFHTLLPFGTRLAQLNPRLVTLAQVAALWPPNLWEVDSSRRFGELFPIQALAKSLVTTWTGPPSDKTSGAGPSGPRLSCWDIDARVVPRISLSVHCIRPGATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1ACC2</accession>
    <name>A0A3S1ACC2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA-binding protein 48</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_004046</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RBM48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000090">
        <property type="protein sequence ID" value="RUS88214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1ACC2"/>
    <dbReference type="STRING" id="188477.A0A3S1ACC2"/>
    <dbReference type="OrthoDB" id="78358at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12442">
        <property type="entry name" value="RRM_RBM48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000424">
        <property type="entry name" value="RNA-binding protein 48 isoform X4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039599">
        <property type="entry name" value="RBM48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034264">
        <property type="entry name" value="RBM48_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20957">
        <property type="entry name" value="RNA-BINDING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20957:SF0">
        <property type="entry name" value="RNA-BINDING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="342"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS88214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="425" mass="47881" checksum="1D886419286A0B8F" modified="2019-04-10" version="1">MEVPSHHLKQKVCVSRPPYREGRHPKAVKVYTVNNESIYLIIQGVPSVGAGGELNKLCSSFGPVEEFRPLDEYPCEDKYTEVYLIKYKKIQSSRFAKRKLDEYSFFGGCLHVFYAPEYESVQETREKLCDRRQVVAKKIRQHNNERTQYRQQRQLALNSAESHEVAVESRVPPLPLPPGTPMQISNPEVPLLHHHADAPEKSTSFAVATTPVIPEESPSLTPAPNCTDFSQPQSESHTEHNVFHLPLPPISIKANGKQKMVRENWRQYEYSKVPTAHATLPQGYDGRLSVPEYNYKTFSVPTHHEVNTEKIKSTDNVNPQDSQIVIRDYKVAKPALKFVPRQTVKKAASGQEAEETRQPAGAGGSQDDNLRKNAFRLGKVQGPEELPGRKRTLPTVAQQSVNDTILSIRGKISKIIGERVGQKPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1ACU1</accession>
    <name>A0A3S1ACU1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UspA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_003633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000078">
        <property type="protein sequence ID" value="RUS88607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1ACU1"/>
    <dbReference type="STRING" id="188477.A0A3S1ACU1"/>
    <dbReference type="OrthoDB" id="843225at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46989">
        <property type="entry name" value="USP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46989:SF3">
        <property type="entry name" value="USPA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="1">
        <location>
            <begin position="68"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS88607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="110" mass="12755" checksum="3739EEF84E7956B5" modified="2019-04-10" version="1">MFFKIQKIWYVQNFHKPENKVVVVHTPEYSMGPSEMSTSKIEESIQEANAKTEMVKTKFVEKMSECGVGTRGLGKFRRTMLGSVSDYILHHAHVPVLVCRLKYLLKDDKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1ATD4</accession>
    <name>A0A3S1ATD4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fibrinogen C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_020656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001192">
        <property type="protein sequence ID" value="RUS71578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1ATD4"/>
    <dbReference type="OrthoDB" id="10542534at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS71578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="31840" checksum="30674F69CE85F4F9" modified="2019-04-10" version="1" fragment="single">MMSEELLSITRESPSRVVSLDTYRANGTLKNNTAFLFVDLVETPEFGADFFVCEVAFTKGSGESGRAFSIAGPGNYTSLLKDGEGRSKQQQVRETEPSLTATTPPAKVFSSPYTSEIWFLGEKLTKVEAKFEKLSERLEKRVSLGVDNVYKRATSLENSVMERVTSAEAAFSGRISRLEDRLASEVLSPSQSRDGGEIPGTPQALVDIERRLDGLELALGNRNMSLNAVTSHGGMSSEKQPDSCFRGMGDDVTKSYPPYVIMTHDTLKREILCDTKTLGGGWTVIQVGKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AZI7</accession>
    <name>A0A3S1AZI7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_019945</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001085">
        <property type="protein sequence ID" value="RUS72299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AZI7"/>
    <dbReference type="STRING" id="188477.A0A3S1AZI7"/>
    <dbReference type="OrthoDB" id="186786at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036149">
        <property type="term" value="P:phosphatidylinositol acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF16">
        <property type="entry name" value="LYSOCARDIOLIPIN ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="5">
        <location>
            <begin position="61"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS72299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="351" mass="40703" checksum="5BDFBE857766EA6F" modified="2019-04-10" version="1">MGTIVMVTPTLPTIFLSPALSRRMMDFLIKLWFLLAVALYEMLMGVKIIVSGKPSLRGTSSLILENHRTRIDWLFLMSYLCRYSDIKEFRISLKYPLKKFPGAGWAMQCAGFLFLKRKWDEDKDHIANGINYFSKVKSKPQFLLFPEGTDMCPFSIKRSHDFAEKNGLTKYNYVLHPRTTGFIHFINEMKKGQIIDSVLDVTVGYPKTLIQSELQALKGIYPEEIHFYVEDHPIHTLPSSEEELAEWLKKLWDRKEERLKKFYEEKRFTCEVGESGDAGNAVMPMKEEDVKVLLIKVVVFWLTFLFAVFACLYIFPLFRLFCFIGCVTYVVIGIRHGGVDNVIYGAVRDHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B213</accession>
    <name>A0A3S1B213_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_019142</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tollip family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000977">
        <property type="protein sequence ID" value="RUS73098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B213"/>
    <dbReference type="STRING" id="188477.A0A3S1B213"/>
    <dbReference type="OrthoDB" id="9942608at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04016">
        <property type="entry name" value="C2_Tollip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14363">
        <property type="entry name" value="CUE_TOLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000036">
        <property type="entry name" value="Toll-interacting protein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000055">
        <property type="entry name" value="Toll-interacting protein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041799">
        <property type="entry name" value="TOLIP_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037301">
        <property type="entry name" value="Tollip_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461:SF5">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="8" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="4" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="56"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="11">
        <location>
            <begin position="240"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS73098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="285" mass="31760" checksum="2FA49F4D07A86B95" modified="2019-04-10" version="1">MATTNDFAASGDQQTEANSQNRRNQVMVGELPTDFLRTGPPLTQEQEDERIAMILQAQQQAGVNVYSTSNVAGRLSISVVQAKLNKNYGLTKMDPYCRVRIGHTVFETPTAYNGAKAPRWNKTVTTYLPVGVDSMYIEIFDERSFTMDDRIAWAHIKIPEVVMAGETSDNWYLLSGRLGDDKEGTVNIVLSLTAPVETNVYSYPTPVPAMYYPATGVAGPMPMFQPPYPPQQPPPSRPLYTEEDLKMVKDMFPNMEDEVIKSVMEANRGNKDATINSLLSMNTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B3E3</accession>
    <name>A0A3S1B3E3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hexosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_017093</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="RQTK01000767">
        <property type="protein sequence ID" value="RUS75153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B3E3"/>
    <dbReference type="OrthoDB" id="2139606at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF3">
        <property type="entry name" value="BETA-1,3-GALACTOSYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS75153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="383" mass="43546" checksum="53D5074B3A084B90" modified="2019-04-10" version="1">MCRHSRRGVLSTMLVSIACTLVVTRFMLPTCSNLSTRSVDSRSPRPAESSSQASFFEAYPWESSNFSECIALENFPKPHVQSFVDLPCLNTPFFKLRESKVSEIPLDFPILSNHICEEKVSVLFVLPSVADEKTKNIRLSIRKTWASRFYGADWRQTSDMKMAFFFGSAGLNQDALDALYRESSTYGDVVVGNFNDTYGNLSLKMAVIISWVAKFCPSVEAVVKVDMDTFVNVDLLLHILTEIPKEEHPAYVLGVQHTFPMPPVIRTGRWAVPKSQYPLDVFPRYMQGHSYVISGPAVRLIAPSFPYFPIVANEDAFVTGIMSQVHNITRFHSSFAEEHTENRIQKFRQNAIVSIVLKGEDRQKLWDRQKLWQSTKTKKCYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B3G6</accession>
    <name>A0A3S1B3G6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EGW08_017049</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">EC2010</strain>
            <tissue evidence="15">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA. Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000764">
        <property type="protein sequence ID" value="RUS75190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B3G6"/>
    <dbReference type="STRING" id="188477.A0A3S1B3G6"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.280">
        <property type="entry name" value="AF1531-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF9">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12836">
        <property type="entry name" value="HHH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4 12" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 11 12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="14">
        <location>
            <begin position="9"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="347"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="437"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="528"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="88"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RUS75190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="637" mass="70517" checksum="DB2BDADE74671EB0" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B619</accession>
    <name>A0A3S1B619_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF4774 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_015283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000621">
        <property type="protein sequence ID" value="RUS76963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B619"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018608439" description="DUF4774 domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS76963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="12743" checksum="DC5E35B72F31C2D3" modified="2019-04-10" version="1">MSRFVLLAVVLALTITLSYQAPLAPQTAFAGSSLIIPKFPPPVGPNRPLGPSFPKGPFPGGPFPGGPIVVSKRSGDSKVDVEVNTGPKGTSGTVSGTHTTSGGTTIKGSISHGPGGTSGGVKVSVPIQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B6D8</accession>
    <name>A0A3S1B6D8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenylate cyclase</fullName>
            <ecNumber evidence="4">4.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">EGW08_011335</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">EC2010</strain>
            <tissue evidence="20">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="4"/>
    <dbReference type="EMBL" id="RQTK01000367">
        <property type="protein sequence ID" value="RUS80899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B6D8"/>
    <dbReference type="STRING" id="188477.A0A3S1B6D8"/>
    <dbReference type="OrthoDB" id="2107370at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000001">
        <property type="entry name" value="Adenylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032628">
        <property type="entry name" value="AC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627:SF16">
        <property type="entry name" value="ADENYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16214">
        <property type="entry name" value="AC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="519"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="549"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="585"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="656"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="681"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="723"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="19">
        <location>
            <begin position="810"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RUS80899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1008" mass="114305" checksum="A86D7AEBFB540624" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B705</accession>
    <name>A0A3S1B705_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_015710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000656">
        <property type="protein sequence ID" value="RUS76517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B705"/>
    <dbReference type="STRING" id="188477.A0A3S1B705"/>
    <dbReference type="OrthoDB" id="1926212at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44523">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44523:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018683696" evidence="2">
        <location>
            <begin position="20"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="152"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="227"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="297"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="365"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS76517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="868" mass="97136" checksum="D0D0E4BCAE3EB2DD" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B7A6</accession>
    <name>A0A3S1B7A6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">IgGFc-binding protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_015481</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000638">
        <property type="protein sequence ID" value="RUS76750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S1B7A6"/>
    <dbReference type="OrthoDB" id="6161995at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035234">
        <property type="entry name" value="IgGFc-bd_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17517">
        <property type="entry name" value="IgGFc_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="339"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1390"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1449"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="domain" description="IgGFc-binding protein N-terminal" evidence="3">
        <location>
            <begin position="418"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="IgGFc-binding protein N-terminal" evidence="3">
        <location>
            <begin position="856"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1218"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1218"/>
            <end position="1240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS76750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1487" mass="161374" checksum="C576CF9046F5EFC2" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B983</accession>
    <name>A0A3S1B983_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EGW08_009451</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">EC2010</strain>
            <tissue evidence="16">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000271">
        <property type="protein sequence ID" value="RUS82787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B983"/>
    <dbReference type="STRING" id="188477.A0A3S1B983"/>
    <dbReference type="OrthoDB" id="125004at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048665">
        <property type="term" value="P:neuron fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09366">
        <property type="entry name" value="LIM1_Isl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000034">
        <property type="entry name" value="Insulin gene enhancer protein ISL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000041">
        <property type="entry name" value="insulin gene enhancer protein ISL-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047169">
        <property type="entry name" value="ISL1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047244">
        <property type="entry name" value="ISL1/2-like_LIM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24204">
        <property type="entry name" value="INSULIN GENE ENHANCER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24204:SF8">
        <property type="entry name" value="TAILUP, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7 10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 10 12" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 11" id="KW-0440">LIM domain</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="14">
        <location>
            <begin position="37"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="14">
        <location>
            <begin position="100"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="15">
        <location>
            <begin position="245"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="247"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="162"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="172"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="217"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="438"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RUS82787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="454" mass="50351" checksum="F1C2F01C36B675F4" modified="2019-04-10" version="1">MALEAPITKKRRLASGADGVHAKGETITKAKEKRSGSMCVGCGSHIVDQYIMQVSPDLSWHASCLKCADCEQYLDESCTCFVRDGKTYCKRDYVRLFGTKCSRCGVGFCREDVVMRPTKSTVYHLNCFRCVVCNKPLVTGDEFAIRDDGLFCRADHDGMDRSVTTSPCQDIGSPGSANGSSNSAIFNNNNNNISSNNNNNNVMRDGGNHNNNNNNHKNSEKSGDNKKSGRSDKSSRGSGGHKSDHKTTRVRTVLNEKQLHTLRTCYNANPRPDALMKEQLTEMTGLSPRVIRVWFQNKRCKDKKRSILMKQMQQQQEKNGGGLSRPLQGVPMVATSPVRHEPGVNMQGQPVEVQSYQTPWKALSEFALQGDMDQPHAPFQQLMSSFDHMDPGLASPPPHGHHPEMMLHHHPSPAHHPDMMMMHRGYMHSDDMVGSVGSDFSGTPSELSHSPISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BAF4</accession>
    <name>A0A3S1BAF4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_012717</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000446">
        <property type="protein sequence ID" value="RUS79519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BAF4"/>
    <dbReference type="STRING" id="188477.A0A3S1BAF4"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08024">
        <property type="entry name" value="GH16_CCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF55">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018525170" description="GH16 domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="160"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS79519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="513" mass="57609" checksum="A5C9E5FC26F90981" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BAI0</accession>
    <name>A0A3S1BAI0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_012660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000443">
        <property type="protein sequence ID" value="RUS79566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BAI0"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS79566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="379" mass="43988" checksum="23635B2D0FFF4BA9" modified="2019-04-10" version="1">MGKAQHQGRPILQCRRLSIKTSQAKKHRSSLQFSYSSNCRPRPLKLISVCCMRLVRRNSTSQAGIPSLIRFDLLFTLCEPQGGPSYFPVQLILCFQSGYVCYDYFKIVISAPQILPLVSNTSLCSGICHCKKAIKGLDSNGLAFSYSSSIEAFLRPEQTYAIRPLTAISFTRQKHRKRCPNLPELPEIDSELQHNQYQLHNNRLKPGCSWTQHCTERSKHCREKSMELTTERFYSIATQSETRSGFHQSPTDASCSHNQISSRSRHTDCNEREHQWKTKPTIGHRQSYRTSEKGSLHLLIPALLLCVIRLCGAEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEVEEEEEKEKGEEEKEKEDAKEEEEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BDF4</accession>
    <name>A0A3S1BDF4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_011255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000362">
        <property type="protein sequence ID" value="RUS80980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BDF4"/>
    <dbReference type="OrthoDB" id="6158578at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS80980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="151" mass="17080" checksum="329EE9B508D3781F" modified="2019-04-10" version="1">MLVYAFLFFLCLGSIVSSSLLLFRGYKKTCDVLELNSHDPTSFKGIISSSRANEPTIPCSQLNTETVQLKSEGESVVVTDVHRAIIIAQVASVVLICLSCLQIIVCMGTFGVIWYHFHFLAMHLYTEEHSLNDDEMDDEWDMHTQNSDYIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BEL5</accession>
    <name>A0A3S1BEL5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ribosomal L1 domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_010384</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the universal ribosomal protein uL1 family. Highly divergent.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000317">
        <property type="protein sequence ID" value="RUS81861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BEL5"/>
    <dbReference type="STRING" id="188477.A0A3S1BEL5"/>
    <dbReference type="OrthoDB" id="10251727at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000004">
        <property type="entry name" value="Ribosomal L1 domain-containing 1-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="286"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="301"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS81861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="337" mass="36924" checksum="7C4D7E5A35FA7710" modified="2019-04-10" version="1">MDCEIVVLDDAKVAKAVAALRQLMSTAEGKNELIEKVDEVELQVCLKKIPQKEQTIKLKLPHSIKNTDAEVCLFVKDLDRTEREYEATIRHTQDLLKKRGVKSIPEIVPMKSLKTEYKPFEAKRNLSNAYDLFLCDIRITHLLPSLLGKHFYGRKKAPIQVDLNAKDLAAEMEAAVSNSRCSISTKGSVSTAIVAHMQMKDQAIADNIIASARQISEKVSGGPINIKLLSLKLKSSASVPLYLGTGGPQEVIVPKRKAPVDVEAEEISTLFGAKVKVFPNGNIEVINEGDGETDSSSKPSLSKKKGLGKRKAAPPKQKGAKKKAKGRVVKKPKKINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BEZ0</accession>
    <name>A0A3S1BEZ0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_009760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000284">
        <property type="protein sequence ID" value="RUS82497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BEZ0"/>
    <dbReference type="OrthoDB" id="10457291at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="2">
        <location>
            <begin position="57"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS82497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="309" mass="34326" checksum="C0DFCEDB92BF3C7B" modified="2019-04-10" version="1">MMGLQVDGNHTSSLFCHLAKRFCCWRARPRHPIKAKRLDEGDCSIGLRLVETRTPAESWYAGCFRRHLEPALTDVVGTGTLTDCSRKCDSQGFLYIAVNDDRCVCEKTLSHYESLPPTTCDLTCKSTPDTRLPCGGKELSGWSVYRADGPWVQDVQSAAAARWVEPGYPTTLLANITLRKFWNINLEPVLESEWSNTVELTWHSRPGVFLLLLPSAAEGVNISANKSQEVLAYSVTFRAPGTFPIGVCNACANWKMKLLGRNKCHPVLFAFVCQFVLIYASICTFVLLYLASMPEAIETSDGVNPQPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BGM8</accession>
    <name>A0A3S1BGM8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_011936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000400">
        <property type="protein sequence ID" value="RUS80298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BGM8"/>
    <dbReference type="OrthoDB" id="6099852at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS80298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="38705" checksum="AFBD7FB40A70C8C6" modified="2019-04-10" version="1">MGNKKSAPRIQNHDDQDESDYEDDDDEPNVILEIEERAECDNVESLSKDCERCEHLYGSAMIDVKDFSLDCLPEALREQQILDYLMTQAKIAVKLQVKKCGFKAGMTFDASGWACVSEDTAIEYASCPLQDCPMNGGNVHKAYGGITVYTNEHVVNKKEEGVNCKIIFFYVRDKADCEETFLLQKDSPDTTEVGTISSSELLSDSDTPVLAWGLCVKQVRENKDLVAIETIFHDPELFNVVSACSTQRICAWTKMPDLLKKELKEHVVVISHPHGRPKVVSVGKLLCLEEASQGERAEKETRYSASTCTGSSGGPVICGHYPYRPFTHSSKREYRDRIENFSLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BIA7</accession>
    <name>A0A3S1BIA7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_010840</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000339">
        <property type="protein sequence ID" value="RUS81402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BIA7"/>
    <dbReference type="STRING" id="188477.A0A3S1BIA7"/>
    <dbReference type="OrthoDB" id="21474at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2100:FF:000002">
        <property type="entry name" value="cell growth-regulating nucleolar protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.490:FF:000001">
        <property type="entry name" value="cell growth-regulating nucleolar protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039999">
        <property type="entry name" value="LYAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058719">
        <property type="entry name" value="WHD_LYAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014898">
        <property type="entry name" value="Znf_C2H2_LYAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13100:SF10">
        <property type="entry name" value="CELL GROWTH-REGULATING NUCLEOLAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13100">
        <property type="entry name" value="CELL GROWTH-REGULATING NUCLEOLAR PROTEIN LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25879">
        <property type="entry name" value="WHD_LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08790">
        <property type="entry name" value="zf-LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51804">
        <property type="entry name" value="ZF_C2HC_LYAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger C2H2 LYAR-type" evidence="10">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Cell growth-regulating nucleolar protein-like winged helix" evidence="11">
        <location>
            <begin position="303"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="177"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS81402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="374" mass="43112" checksum="93A8BE39B77F3101" modified="2019-04-10" version="1">MVFFNCNACGEALKKNQVEKHTLRCRSCEVLSCVDCGKDFWGNDYQSHTKCMTEEEKYCGQGYVPKVNKGEAKQEQWIQKVQEAIDKSASNHGLKNLLIKLKDYPNIPRKQQKFQNFLKNSLRINNDYLITQVWNTLMAHSEQDKSKETANNIAPNLKHGINDNGSVGASENKEVEITNSKSISNEEDPKTENVEPKKNKRERKEERQNKANKKEKKDRTETVENGEEPLKKSKKRRHRDDDLEEPTSEEMAATANGTSENQPPKKKKKKKHATEDHGQENEMEENLTAADDQLDCEEPKKNGKFNWEQTITKVLESKGEISLKKLRKKVLNEFAAYGSMNHSEENLWAKFDKKVRKMPSVQVLKDKAKLKESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BJE8</accession>
    <name>A0A3S1BJE8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small monomeric GTPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_007199</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000184">
        <property type="protein sequence ID" value="RUS85062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BJE8"/>
    <dbReference type="STRING" id="188477.A0A3S1BJE8"/>
    <dbReference type="OrthoDB" id="25818at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS85062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="16041" checksum="1BE2556F202A4AC8" modified="2019-04-10" version="1" fragment="single">FTTECRVNGQDYLLHSVDTAGQDEYSVIPQSYFININGYVLVYSVNSQKSFEVVKHVYDKIIDMKGRMTVPIVLVGNKKDLRFERVISEEEGRRLAESWKVPFLEASAKEHPSVKDVFETAINTMTLKENGDSGEKSGCVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BLQ2</accession>
    <name>A0A3S1BLQ2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_005609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000133">
        <property type="protein sequence ID" value="RUS86593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BLQ2"/>
    <dbReference type="OrthoDB" id="10070978at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS86593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="108" mass="11954" checksum="0892BD9C945A708B" modified="2019-04-10" version="1" fragment="single">MIVGYYGDRVMIVCKHGDIVMIVGYYGDIVMIVSNHGDIVMIVSNHGYIVMIVSNHEDKVMIVSNHGYIVMIVGNHGDIVMIVGNHGDKVIMVNKHGIIVIIKAKHKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BQK4</accession>
    <name>A0A3S1BQK4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_003177</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000067">
        <property type="protein sequence ID" value="RUS89066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BQK4"/>
    <dbReference type="STRING" id="188477.A0A3S1BQK4"/>
    <dbReference type="OrthoDB" id="6150098at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="32"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS89066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="249" mass="28505" checksum="28172A8E8C04D053" modified="2019-04-10" version="1" fragment="single">HSMDPDSLILYKFTMPASLVCEPFIMVLITGSVYTTVILSLDRCLAVLRPLHWASILTRRRMKLALLLVFIFAVVVDSPVYFQAELRVAYFPKFNDSFLSGRPTEYYFSWFHQEVYLRHIMPVVQIIVPLVLIVTSNAAIVAKLFQHKRKSSALQGKPRGVDFSKLTAQVIAISVITLTSRVLAAANFYIVTEEEIFYIKYCSRACAWTGAFNIFFIKINSSVNFVFYCFFGGKFRKVFKTTFGCFLCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BQS6</accession>
    <name>A0A3S1BQS6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein phosphatase 1 regulatory subunit 35 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_019613</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PPP1R35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001042">
        <property type="protein sequence ID" value="RUS72615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BQS6"/>
    <dbReference type="STRING" id="188477.A0A3S1BQS6"/>
    <dbReference type="OrthoDB" id="8942190at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019902">
        <property type="term" value="F:phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903724">
        <property type="term" value="P:positive regulation of centriole elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045724">
        <property type="term" value="P:positive regulation of cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033590">
        <property type="entry name" value="PPP1R35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029135">
        <property type="entry name" value="PPP1R35_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28625">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28625:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15503">
        <property type="entry name" value="PPP1R35_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein phosphatase 1 regulatory subunit 35 C-terminal" evidence="6">
        <location>
            <begin position="459"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="180"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="244"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="366"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="535"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="544"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS72615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="612" mass="66380" checksum="35008C6F9CE8B264" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BSC6</accession>
    <name>A0A3S1BSC6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Golgi pH regulator conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_002062</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>bromide(in) = bromide(out)</text>
            <dbReference type="Rhea" id="RHEA:75383"/>
            <dbReference type="ChEBI" id="CHEBI:15858"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>fluoride(in) = fluoride(out)</text>
            <dbReference type="Rhea" id="RHEA:76159"/>
            <dbReference type="ChEBI" id="CHEBI:17051"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>iodide(out) = iodide(in)</text>
            <dbReference type="Rhea" id="RHEA:66324"/>
            <dbReference type="ChEBI" id="CHEBI:16382"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Golgi pH regulator (TC 1.A.38) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000038">
        <property type="protein sequence ID" value="RUS90183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BSC6"/>
    <dbReference type="STRING" id="188477.A0A3S1BSC6"/>
    <dbReference type="OrthoDB" id="264392at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008308">
        <property type="term" value="F:voltage-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051452">
        <property type="term" value="P:intracellular pH reduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025969">
        <property type="entry name" value="ABA_GPCR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022535">
        <property type="entry name" value="Golgi_pH-regulator_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015672">
        <property type="entry name" value="GPHR/GTG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 89-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948:SF0">
        <property type="entry name" value="GOLGI PH REGULATOR A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12430">
        <property type="entry name" value="ABA_GPCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12537">
        <property type="entry name" value="GPHR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="353"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Golgi pH regulator conserved" evidence="11">
        <location>
            <begin position="146"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Abscisic acid G-protein coupled receptor-like" evidence="10">
        <location>
            <begin position="285"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS90183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="447" mass="51423" checksum="CCA218A42BD059D5" modified="2019-04-10" version="1" fragment="single">MSFLVDSLIMSFSMMIFFGGGWVFFLKQLYKDYEVHHSVVLLIFSVTFALSCIMFELIIFEIIDIMDSSSRFFHWKLGLYAILFVLIAVLPFYIAYYLVQNIPIVPQARHIRLLVTIVAWVMTLYFFWKIGDPFPILSPKHALLGFSIEQCIGRVGVIGVTLMAILSGFGAVNCPYTYMSYFIRQVDVTDSDIHRIEKRLLQTIDRIIAKKKKIAEAKRESLRQAQRSTPSTGIWGLLKSAATSVTSATENLAPLKEETKHAEELSRQLFLESADLHDAKDRIEYSKTLKGQYFNVLGHFFSLYCVVKIGLATFNIVFDRVGKIDPVTRWIDIAVKYFGFEFDIKFWSQQISFFLVGVIIVTSIRGFLITLTRFFYAIASSKSSNVIVLCLAQIMGMYFVSCVLLMRMNMPQEYRMIITEVLGDLQFNFYHRWFDAIFLVSAVLSMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BSF8</accession>
    <name>A0A3S1BSF8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_018397</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000894">
        <property type="protein sequence ID" value="RUS73853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BSF8"/>
    <dbReference type="STRING" id="188477.A0A3S1BSF8"/>
    <dbReference type="OrthoDB" id="18894at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd21092">
        <property type="entry name" value="TPT_S35C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="51"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS73853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="356" mass="40328" checksum="1DEC5DDE78DB489E" modified="2019-04-10" version="1" fragment="single">MQDFFKMGKKRVTFKHQHLDLLELKSTLKDQERRVKASLCSATFFTTALKTVGLVLFYYVFSIGLTFYNRRMFKNGHFALSITMCHLLLKFVAAGIVRSLMECKSEDPRVSLGWGVYLKRVALAGVVSSLDIGLSNWSFELITVSLYTMSKTTAVIFILFFSIIFKLEKFRWSLLVVVLCIFTGLFMFTYHSTQFNLEGFILVMTASVLSGMRWTLAQVVMQKNELGLHNPIDMMYHMQPWMILALLPLSAGLELQSVSTSELYFRFTDYSVLMSSIGMILLGGALGFMLEFSEFLLLSHTSSLTLSISGIFKELCIFALAYFVNHDQMNFVNAIGLAVCLLGIVIHVVTKAIYSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BTF4</accession>
    <name>A0A3S1BTF4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_001080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000017">
        <property type="protein sequence ID" value="RUS91167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BTF4"/>
    <dbReference type="STRING" id="188477.A0A3S1BTF4"/>
    <dbReference type="OrthoDB" id="6158132at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS91167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="380" mass="41745" checksum="C258B595591B6E19" modified="2019-04-10" version="1">MPAINCTAHHLVLHVPRDLALTRLLALLNVTLTPQHDPDLSPLEGGALGSRDHRTDSQGAMKFTVAVVLLYGVGVILMLGFHIRKSKWTETTEDDATRVVQKFDRNKSRMDRKYHKTRIENLVRSIHSVPLADVLASIDERSTLPDTDVLASIDERSTLPDTDVLASIDERSTLPDTDVLASIDERSTLPDTDVLASIDERSTLPDTDVLASVDERSTLPDTDVLVPIDGRSTLPDTDVLVSIDERSTLPDTDVLASVDERSTLPDTDVLVSIDERSTLPDSDVLVTIDERSTLLDANVLLPIDERSTLPDTYVLLPIDERSTLPDTDAMLHRSNGERSTLLDREPSSLVHNNYAGTHVAATSANVSKRNGGVFCDRNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BUE4</accession>
    <name>A0A3S1BUE4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA-intron lyase</fullName>
            <ecNumber evidence="2">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_003221</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>pretRNA = a 3'-half-tRNA molecule with a 5'-OH end + a 5'-half-tRNA molecule with a 2',3'-cyclic phosphate end + an intron with a 2',3'-cyclic phosphate and a 5'-hydroxyl terminus.</text>
            <dbReference type="EC" id="4.6.1.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="2"/>
    <dbReference type="EMBL" id="RQTK01000069">
        <property type="protein sequence ID" value="RUS88974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BUE4"/>
    <dbReference type="STRING" id="188477.A0A3S1BUE4"/>
    <dbReference type="OrthoDB" id="10249562at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="5">
        <location>
            <begin position="104"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR011789-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS88974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="242" mass="28270" checksum="225101FE05B3239E" modified="2019-04-10" version="1">MPRSKQEAKKRKKRRPYYLKDAPFPVPIHSMVAEPMGKGAWFYYTGYIEGSAVVVKHSGDIDFLHKMAFFLSYGLGCLRVLDPEMKLLSLREMWSQFRLLKEQFVPHYVAYHYFRSKGWVPKSGLKFGCDFILYQEGPPFYHGSYSVVVQCVREGSLLPCTRRDGYQLDHRHLSWISLAGLNRITEHVAKELMFCYVIWPKNLSAEELASPDCIAKFKVKEMLVSRWISSQERENKTEEEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BW84</accession>
    <name>A0A3S1BW84_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PAN2-PAN3 deadenylation complex catalytic subunit PAN2</fullName>
            <ecNumber evidence="9">3.1.13.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">PAB1P-dependent poly(A)-specific ribonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Poly(A)-nuclease deadenylation complex subunit 2</fullName>
            <shortName evidence="9">PAN deadenylation complex subunit 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PAN2</name>
        <name evidence="12" type="ORF">EGW08_015753</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="9">Binds 2 metal cations per subunit in the catalytic exonuclease domain.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Positively regulated by the regulatory subunit PAN3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a heterotrimer with an asymmetric homodimer of the regulatory subunit PAN3 to form the poly(A)-nuclease (PAN) deadenylation complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
            <location evidence="9">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <text evidence="9">Shuttles between nucleus and cytoplasm.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with PAN3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase C19 family. PAN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="9"/>
    <dbReference type="EMBL" id="RQTK01000659">
        <property type="protein sequence ID" value="RUS76469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S1BW84"/>
    <dbReference type="OrthoDB" id="16516at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010606">
        <property type="term" value="P:positive regulation of cytoplasmic mRNA processing body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06143">
        <property type="entry name" value="PAN2_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000011">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex catalytic subunit PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03182">
        <property type="entry name" value="PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030843">
        <property type="entry name" value="PAN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050785">
        <property type="entry name" value="PAN2-PAN3_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048841">
        <property type="entry name" value="PAN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028881">
        <property type="entry name" value="PAN2_UCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728">
        <property type="entry name" value="DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728:SF0">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20770">
        <property type="entry name" value="PAN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13423">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="11">
        <location>
            <begin position="796"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="235"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="912"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="246"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="922"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="954"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="964"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="1324"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="1326"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="1433"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="1485"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS76469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1540" mass="174812" checksum="3305E487E91F7AAD" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BWD1</accession>
    <name>A0A3S1BWD1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_001918</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000035">
        <property type="protein sequence ID" value="RUS90320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BWD1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS90320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="128" mass="14123" checksum="D5C83357FF66D0D3" modified="2019-04-10" version="1" fragment="single">LFGWRCLVELESVQQVGELTQIYLTVLSAGRGLDEEVDLLVRELAVSGGLDLLESGPRLLRVQLSTVVGVQLFELGHNLLGAACHYSLLPHARAEHLELPDAELPVHVLVECLKHHVRLGVVQPELRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C7N6</accession>
    <name>A0A3S1C7N6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_007041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000178">
        <property type="protein sequence ID" value="RUS85215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C7N6"/>
    <dbReference type="STRING" id="188477.A0A3S1C7N6"/>
    <dbReference type="OrthoDB" id="6084077at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="350"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS85215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="820" mass="90454" checksum="60AC6099F321028D" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1CEQ5</accession>
    <name>A0A3S1CEQ5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA helicase MCM9</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Minichromosome maintenance 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">EGW08_001633</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">EC2010</strain>
            <tissue evidence="19">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="RQTK01000028">
        <property type="protein sequence ID" value="RUS90636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S1CEQ5"/>
    <dbReference type="OrthoDB" id="271325at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058768">
        <property type="entry name" value="MCM9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF48">
        <property type="entry name" value="DNA HELICASE MCM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26066">
        <property type="entry name" value="MCM9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
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            <end position="578"/>
        </location>
    </feature>
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            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
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    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
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            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
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        </location>
    </feature>
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            <begin position="1226"/>
            <end position="1245"/>
        </location>
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            <begin position="12"/>
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        </location>
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        </location>
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            <begin position="842"/>
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        </location>
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            <end position="971"/>
        </location>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
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            <end position="1052"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
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        </location>
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        </location>
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            <end position="1216"/>
        </location>
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        <location>
            <begin position="1235"/>
            <end position="1244"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041085"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RUS90636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1342" mass="148746" checksum="911BB543BCC12809" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H599</accession>
    <name>A0A3S1H599_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2HC/C3H-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_019742</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001061">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="188477.A0A3S1H599"/>
    <dbReference type="OrthoDB" id="265955at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026319">
        <property type="entry name" value="ZC2HC1A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049899">
        <property type="entry name" value="Znf_C2HC_C3H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13555">
        <property type="entry name" value="C2H2 ZINC FINGER CGI-62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13555:SF66">
        <property type="entry name" value="ZINC FINGER PROTEIN 474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13913">
        <property type="entry name" value="zf-C2HC_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52027">
        <property type="entry name" value="ZF_C2HC_C3H"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="3"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="77"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="189"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="260"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="318"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="388"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="438"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="513"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="98"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="286"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="144"/>
            <end position="156"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="286"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS72488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="543" mass="60190" checksum="1AD89CB152A85838" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HD46</accession>
    <name>A0A3S1HD46_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amine oxidase</fullName>
            <ecNumber evidence="6">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_015285</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="6">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="6"/>
    <dbReference type="EMBL" id="RQTK01000621">
        <property type="protein sequence ID" value="RUS76965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HD46"/>
    <dbReference type="STRING" id="188477.A0A3S1HD46"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF20">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0186">Copper</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="7">
        <location>
            <begin position="93"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS76965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="159" mass="18603" checksum="756D19CD6D03F23D" modified="2019-04-10" version="1" fragment="single">MWIWALRPAPFPLLHPTDFGIQFNLTGSDSNQWSINRVWYHGQVFDSLQDLARRYADGTIEKSNMTSPVYTEDLFSTLHRRGDYSPPNAQRPPTIVEPDGKRYSIKDKKVTYLDWTFHYRHSSFFGPQLFDIRFKGERIVYELMVSEIASFYSGDVPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HG52</accession>
    <name>A0A3S1HG52_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_013531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000494">
        <property type="protein sequence ID" value="RUS78710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HG52"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601:SF1">
        <property type="entry name" value="ADF-H DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601">
        <property type="entry name" value="ULP_PROTEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS78710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="530" mass="60431" checksum="E5611A2549CFFB99" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HIM6</accession>
    <name>A0A3S1HIM6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">2-(3-amino-3-carboxypropyl)histidine synthase subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_012038</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the DPH1/DPH2 family. DPH2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000405">
        <property type="protein sequence ID" value="RUS80213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HIM6"/>
    <dbReference type="STRING" id="188477.A0A3S1HIM6"/>
    <dbReference type="OrthoDB" id="449241at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000002">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010014">
        <property type="entry name" value="DHP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00272">
        <property type="entry name" value="DPH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF2">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01121">
        <property type="entry name" value="Diphthamide_biosynthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00408">
        <property type="entry name" value="Diphthamide_biosynthesis_famil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS80213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="503" mass="55465" checksum="BCD4784B549ADF3E" modified="2019-04-10" version="1">MSTSAFSASDDVIHRTIECHTVKTSTDNLKIVYEIERCVTWIQQSNFKKVALQFPDVLLVDAPSVAKEIENCVPEISAFILGDTSYGSCCVDEVGAQHNRADCLIHFGRACLSPTVRLPVLYVFGRSPIDTNQCVFEVKKALTPDTKVVFVYDTTYNYVADDVYMKLKSNFQDLVFSRLLDPSTTLLSNYSFGLHKVSNSLDASSHQLIHKSSDQDQATVCKCGRYISLPFGSTLEDYTFLFIGASESSALVNMMMTFNKNNFYTYDPSKSSCEKETVKINKALMKRYYLIERTKDANIVGIVAGTLGVAKYKDMIDHLKVLLKAAGKKSYTFVVGKLNPAKLANFAEVDIYVLVACPESCLLEQTEFYRPVVSPLEVEMACNQAREWTGDYSTDFRDLLPGGSMFIKASPFKESGTTDVSLIDNKIRTLGVVDNPDPGKSAQQTVAIRSDASVVANVAQNAGEFLAGRSWQGLDRKLGETPVVKATDGQHGIAASYDNEPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HS93</accession>
    <name>A0A3S1HS93_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6451 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_007147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000182">
        <property type="protein sequence ID" value="RUS85095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HS93"/>
    <dbReference type="OrthoDB" id="6925859at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045609">
        <property type="entry name" value="DUF6451"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20049">
        <property type="entry name" value="DUF6451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6451" evidence="2">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS85095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="235" mass="26897" checksum="BF1F70026AF3C74D" modified="2019-04-10" version="1">MSEQAQALPQRQTRSSQNLLIEMTVSRLRSLTHCLLLSVVTFILVIIAFHSLDDLRNTSPVLLMSGNLDLMRLTSGPNVTLTQGSNVTASLHSAEICRRHQPSLPKATGRKREALSCGRKSRKKGLQINIRKTKAMRINNKLSCSVVNKDGGTDEDIRCRINKDRYVFNTLKPIWMSTALIVRNKIWIFKTRTTKLLFSSRCLRNILSIRWLEVSKKRTVDYKEANPHRDRDQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HTH0</accession>
    <name>A0A3S1HTH0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutathione transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_006418</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">S-crystallins are structural components of squids and octopi eye lens. Contains relatively little if any GST activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000159">
        <property type="protein sequence ID" value="RUS85789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HTH0"/>
    <dbReference type="STRING" id="188477.A0A3S1HTH0"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005212">
        <property type="term" value="F:structural constituent of eye lens"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000030">
        <property type="entry name" value="Glutathione S-transferase S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000035">
        <property type="entry name" value="hematopoietic prostaglandin D synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF150">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0273">Eye lens protein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="4">
        <location>
            <begin position="43"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="5">
        <location>
            <begin position="122"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00049616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS85789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="27926" checksum="3E7FC9B7FD78258A" modified="2019-04-10" version="1" fragment="single">YSAFSHATCHLRVATIRIISCPLSVEFCRDKFEPPVSADLTMPSYKLNYFDARGRGEVIRLVFAAAGQEFEDNRVSREDWPALKPKTPFGQMPALEVDGEMIAQTGAICNYLAKEFGLYGKSSKETCLIDQIVCLVNDFFMATVKVMYLEKDEAKKAELMVAFKEEECPKYMGYFESLLKKNGTGFYVGSEVSLADIFVYDLVWNLNSRDPSPFNIDSYPLVKEHQNKIGSLPTIKAYLAARKHTDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HWD1</accession>
    <name>A0A3S1HWD1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mediator of RNA polymerase II transcription subunit 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mediator complex subunit 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_004768</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000110">
        <property type="protein sequence ID" value="RUS87452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HWD1"/>
    <dbReference type="STRING" id="188477.A0A3S1HWD1"/>
    <dbReference type="OrthoDB" id="205099at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056877">
        <property type="entry name" value="Med14_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055113">
        <property type="entry name" value="Med14_RM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055114">
        <property type="entry name" value="Med14_RM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055107">
        <property type="entry name" value="Med14_RM8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013947">
        <property type="entry name" value="Mediator_Med14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056879">
        <property type="entry name" value="RM3_Med14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056878">
        <property type="entry name" value="RM5_Med14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809">
        <property type="entry name" value="MEDIATOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25069">
        <property type="entry name" value="Med14_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22981">
        <property type="entry name" value="RM2_Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25065">
        <property type="entry name" value="RM3_Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25067">
        <property type="entry name" value="RM5_Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22984">
        <property type="entry name" value="RM6_Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22983">
        <property type="entry name" value="RM8_Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Mediator of RNA polymerase II transcription subunit 14 RM2" evidence="5">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator of RNA polymerase II transcription subunit 14 RM3" evidence="8">
        <location>
            <begin position="84"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator of RNA polymerase II transcription subunit 14 RM5" evidence="9">
        <location>
            <begin position="368"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator of RNA polymerase II transcription subunit 14 RM6" evidence="7">
        <location>
            <begin position="494"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator of RNA polymerase II transcription subunit 14 RM8" evidence="6">
        <location>
            <begin position="949"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator of RNA polymerase II transcription subunit 14 C-terminal" evidence="10">
        <location>
            <begin position="1036"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="676"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="825"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="699"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="770"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="787"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="849"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00019619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00032007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS87452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1173" mass="129606" checksum="58876A585B1F1D88" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SHZ7</accession>
    <name>A0A433SHZ7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_023846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01004201">
        <property type="protein sequence ID" value="RUS68392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SHZ7"/>
    <dbReference type="OrthoDB" id="6150230at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS68392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="216" mass="23662" checksum="6A2A2C9F4145FA40" modified="2019-05-08" version="1">MGTARHEINTVSVGFSRADERAPDTARAAVLYGADVPISGQAASREGAPYKEKRTLPGAPADVPHFVCVTARGRWGHSPCPDLHPRRLHPGSLPRLPRSPRRPSYSSLLGFGITRDGPVWVRRSSAIHFQGWLIRQNRYGLPPEFPLASFYSSIVHHLSGPSMRAPAPPHRRRGRDGPVVRPSPRWEKGSHLGKPETALAFTAPLGFVPLNDSRAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SJW5</accession>
    <name>A0A433SJW5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_022827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001692">
        <property type="protein sequence ID" value="RUS69412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10573747at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS69412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="155" mass="16512" checksum="0E93187F30D2C5B7" modified="2019-05-08" version="1" fragment="single">APVASLQSAKCSVVSLDGSFSSPGTGWSQKRSNSVSMGGFEMSGRGNSSTSSSPGPREMMSPSPPCPHRGHSSLVRLEKLHLSFNYLTSVALTKTKDSPKDSRSTDTNSICSMESEEIQGRLLFPHISELDLGCNKLTSLSPDIGEHVSLKILTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SKA7</accession>
    <name>A0A433SKA7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_022681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001639">
        <property type="protein sequence ID" value="RUS69559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SKA7"/>
    <dbReference type="OrthoDB" id="10631747at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS69559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="255" mass="29386" checksum="E30C2B769CEBD8AE" modified="2019-05-08" version="1" fragment="single">RSRDTYSSQIPRERDRSYAPRGGSGGRYPSARGDYSPMRETSSYRDSYSDRKDSYRSSAREYPSSRSSDYRGERLPRESIRDYGSSREYPPPSREYRDTMRDDFRDLPPRDRYHGSDLSPPHRSSYVDRREREDSPYREDSRRDYTSRSFSSRITDRPPRDYPPSREYRGRGGPRGGIRGGRDFFSNGRGSRGGPYRSRGGPPRGRGGPPRGRGARPDFYPRDGGRRSSLSPPPSRDGPGAKRPRLSPDDSYSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SM32</accession>
    <name>A0A433SM32_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_022028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001464">
        <property type="protein sequence ID" value="RUS70211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SM32"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="670"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1062"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1110"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1170"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="787"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1069"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1114"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1170"/>
            <end position="1197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS70211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1272" mass="143707" checksum="928B0462037EBB23" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SS31</accession>
    <name>A0A433SS31_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Laminin subunit alpha-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">EGW08_020153</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">EC2010</strain>
            <tissue evidence="19">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001116">
        <property type="protein sequence ID" value="RUS72081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A433SS31"/>
    <dbReference type="OrthoDB" id="10011303at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000106">
        <property type="entry name" value="Heparan sulfate proteoglycan 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000074">
        <property type="entry name" value="Laminin subunit alpha"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000090">
        <property type="entry name" value="laminin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000069">
        <property type="entry name" value="Laminin subunit alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000082">
        <property type="entry name" value="Laminin subunit alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000512">
        <property type="entry name" value="Laminin subunit alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000033">
        <property type="entry name" value="Laminin subunit alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000017">
        <property type="entry name" value="Laminin subunit alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000209">
        <property type="entry name" value="Laminin subunit alpha 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000130">
        <property type="entry name" value="Laminin subunit beta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050440">
        <property type="entry name" value="Laminin/Netrin_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000034">
        <property type="entry name" value="Laminin_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008211">
        <property type="entry name" value="Laminin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574:SF436">
        <property type="entry name" value="LAMININ SUBUNIT ALPHA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574">
        <property type="entry name" value="NETRIN/LAMININ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00052">
        <property type="entry name" value="Laminin_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00054">
        <property type="entry name" value="Laminin_G_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00055">
        <property type="entry name" value="Laminin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00281">
        <property type="entry name" value="LamB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00136">
        <property type="entry name" value="LamNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51115">
        <property type="entry name" value="LAMININ_IVA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51117">
        <property type="entry name" value="LAMININ_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019265886" description="Laminin subunit alpha-2" evidence="14">
        <location>
            <begin position="29"/>
            <end position="3186"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin N-terminal" evidence="18">
        <location>
            <begin position="30"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="466"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin IV type A" evidence="17">
        <location>
            <begin position="535"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="757"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="869"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="921"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="968"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="1016"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="1066"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="1161"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="1207"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin IV type A" evidence="17">
        <location>
            <begin position="1282"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="1514"/>
            <end position="1563"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="1564"/>
            <end position="1620"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="1621"/>
            <end position="1668"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="15">
        <location>
            <begin position="2223"/>
            <end position="2402"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="15">
        <location>
            <begin position="2415"/>
            <end position="2591"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="15">
        <location>
            <begin position="2598"/>
            <end position="2771"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="15">
        <location>
            <begin position="2826"/>
            <end position="3000"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="15">
        <location>
            <begin position="3005"/>
            <end position="3183"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1872"/>
            <end position="1930"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1970"/>
            <end position="2004"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="2045"/>
            <end position="2100"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="2170"/>
            <end position="2225"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="485"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="776"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="893"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="921"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="923"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="942"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="968"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="970"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="989"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1038"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1066"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1068"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1087"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1161"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1163"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1182"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1236"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1533"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1591"/>
            <end position="1600"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1621"/>
            <end position="1633"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1623"/>
            <end position="1640"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1642"/>
            <end position="1651"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="2564"/>
            <end position="2591"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="2744"/>
            <end position="2771"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="2973"/>
            <end position="3000"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="3156"/>
            <end position="3183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RUS72081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3186" mass="353644" checksum="13386F84B2728BAC" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433STD1</accession>
    <name>A0A433STD1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_019762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001062">
        <property type="protein sequence ID" value="RUS72480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433STD1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS72480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="290" mass="32129" checksum="E60F7D51E222E6F4" modified="2019-05-08" version="1" fragment="single">NQTNLYLSKILFLYPSQPNNQPTNPPTNQANLYLSKILILSQPTNQTKPICISQGSCFCIHQSTNQPTNQTKPNCISQRSCFCIHQPNQTNLYLSKILSLYPSTNQPNNQPSKSNQSVSLKDLDSVSTNQPNQSVSLKRSCSPNQPNQSVSLKDLVSVSTNPTKPICISQRSCFCINQPNQTNLYLSKILFMSPPTKPNQSVSLKGLVSVSTNQPTNQPTKQPTKPTKPICISQRSCFCIHQPTKPICISQGSDFCLHQPNQTNLYLSKILSLPQPTNQPTNQSKPICIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433STG8</accession>
    <name>A0A433STG8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_019678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001053">
        <property type="protein sequence ID" value="RUS72559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433STG8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018992506" evidence="1">
        <location>
            <begin position="25"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS72559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="200" mass="22193" checksum="74F5066F14CC60EB" modified="2019-05-08" version="1">MMEQQLIIFVVILSGMVSHCLVEASPCQNPDKRPCFCSTSEGDVSLQALMDSQPNRDPLSVTSGGYTYYIAPCDNPITVTDCKNLNPDLVGCQVQTQTQSPGAFGMGLRYNYAVTGDPQKDTVVFINQFKDPLAGTIRVMRLHLACLSSEAGKLSFVNQTDPGPTTITYILCRYYCVSCWWNIVPQVCEKGRRQRIHPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433STS9</accession>
    <name>A0A433STS9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_019564</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001034">
        <property type="protein sequence ID" value="RUS72668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433STS9"/>
    <dbReference type="OrthoDB" id="449345at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012548">
        <property type="entry name" value="MATCAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31817">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31817:SF5">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08014">
        <property type="entry name" value="MATCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01154">
        <property type="entry name" value="DUF1704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="645"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="390"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="669"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS72668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="910" mass="103643" checksum="E9D633C9C69B5F9D" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SVP1</accession>
    <name>A0A433SVP1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MaoC-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_018879</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000945">
        <property type="protein sequence ID" value="RUS73360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SVP1"/>
    <dbReference type="OrthoDB" id="533830at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018812">
        <property type="term" value="F:3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03441">
        <property type="entry name" value="R_hydratase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43841:SF3">
        <property type="entry name" value="(3R)-HYDROXYACYL-ACP DEHYDRATASE SUBUNIT HADB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43841">
        <property type="entry name" value="3-HYDROXYACYL-THIOESTER DEHYDRATASE HTDX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="MaoC-like" evidence="2">
        <location>
            <begin position="260"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS73360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="382" mass="43995" checksum="15ECBE3952F857BE" modified="2019-05-08" version="1">MWFLLHILLYVAFIIAALAVLLELIYVNIRVNTKTRRNQTMSELEIPPIAIFYFCAFMQTFHMSPAVFYPTLPSDKLTPVDPDSPEGRQGVTAKFYPPRTEKVFTPQCYMRFRELEIYKKVIGFRGGPAEIPPIWMCSYFNKAIISLGSSEFSRVRILDNAGAGDSIHRLFSGMVHLSQQITVYQDLSPLLHGHFTVTFLNEEYRMTTRGLENTVRGCVWGRNDVLMWECVMTGISILPNHKKGKRVPPRKPDFHIYKQEEIKAPENIGMVFARATQDYQPQHISKRTAKLVGFNSPIAHGLWTMAVSVDKIMDNEQRSFKDKYPLHLEVHFKRPMIFPGTAYLQYDKPRDPSHLTNFRLVQPQNTIPILVGLMHTGESLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SWM6</accession>
    <name>A0A433SWM6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_018535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000908">
        <property type="protein sequence ID" value="RUS73703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SWM6"/>
    <dbReference type="STRING" id="188477.A0A433SWM6"/>
    <dbReference type="OrthoDB" id="10057281at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035082">
        <property type="term" value="P:axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027968">
        <property type="entry name" value="JHY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14726">
        <property type="entry name" value="JHY PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14726:SF1">
        <property type="entry name" value="JHY PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15261">
        <property type="entry name" value="JHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS73703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="378" mass="42841" checksum="FDC702C0F54A8F52" modified="2019-05-08" version="1" fragment="single">QVSIPISPRLGEIQLQPIHQQIITEDGQRISVDVNLRLVSPPSVQAGSPAHSSQHPLHQQQQQPQQQHQHQQYSRARQYPTAPQYNEEELFDDRGVYQDYQAAGEPLFTAADFKYVSPRGRYSADEVLRALSESRTELNPYGKVPPIDGAGGRGYRDDEHPTSAPVTDQGGSYMDVYMRQRDKDADKPWYRVYGLKDYRKMQKEVRLGTLGPDLDSEATRERREKAQRQQDYAKVVMERNRSELVNKKPPSFPRPKENNDIMNRRKVATEYAKSVPKPTVRVRPTEYNNYELASEKSPIAKHHRKVTSGGSGLIPESPTGGASVTPGGAKFSPGPHHASKPGGRDKDMEVLDLERLRQRYEQDKQSEAAIRQTSGRTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SWV3</accession>
    <name>A0A433SWV3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AIG1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_018446</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000899">
        <property type="protein sequence ID" value="RUS73787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SWV3"/>
    <dbReference type="STRING" id="188477.A0A433SWV3"/>
    <dbReference type="OrthoDB" id="6056605at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00081">
        <property type="entry name" value="Hint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000840">
        <property type="entry name" value="Immune-associated nucleotide-binding protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.16.10">
        <property type="entry name" value="Hedgehog/Intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006703">
        <property type="entry name" value="G_AIG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045058">
        <property type="entry name" value="GIMA/IAN/Toc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001767">
        <property type="entry name" value="Hedgehog_Hint"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903:SF184">
        <property type="entry name" value="GTP-BINDING PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903">
        <property type="entry name" value="GTPASE, IMAP FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04548">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01079">
        <property type="entry name" value="Hint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="Hedgehog/intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51720">
        <property type="entry name" value="G_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIG1-type G" evidence="5">
        <location>
            <begin position="478"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="110"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="300"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="781"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="781"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="798"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS73787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1081" mass="119159" checksum="8A7BA73C5B100033" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T2L3</accession>
    <name>A0A433T2L3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G8 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_016452</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000711">
        <property type="protein sequence ID" value="RUS75791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T2L3"/>
    <dbReference type="STRING" id="188477.A0A433T2L3"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052252">
        <property type="entry name" value="CEMIP/CEMIP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055401">
        <property type="entry name" value="CEMIP_beta-hel_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055400">
        <property type="entry name" value="CEMIP_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039477">
        <property type="entry name" value="ILEI/PANDER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15535:SF17">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15535">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24606">
        <property type="entry name" value="CEMIP_beta-hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24605">
        <property type="entry name" value="CEMIP_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15711">
        <property type="entry name" value="ILEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ILEI/PANDER" evidence="2">
        <location>
            <begin position="56"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="CEMIP beta-helix" evidence="4">
        <location>
            <begin position="310"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="CEMIP" evidence="3">
        <location>
            <begin position="808"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="990"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS75791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1020" mass="116017" checksum="B1657580E38581D3" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T2R6</accession>
    <name>A0A433T2R6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_016391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000706">
        <property type="protein sequence ID" value="RUS75845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T2R6"/>
    <dbReference type="OrthoDB" id="6162574at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS75845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="482" mass="53318" checksum="3F2A3842320B4B51" modified="2019-05-08" version="1" fragment="single">MASDKDVKFNMKGQGMPRMSSPFRKSMFKSRDTSFVFAEGDTKGIQCLTSPRQRRLSAPSILNAPKFSREEDLTKQTIERYLKLDSTLSKKAIAEIIDMVQDMSLSNIMVVRKLRPYFVDNVILWQGLSVYIMRCIDPLSTRYSMNDPSQRISFGTDTYSFSSQSSSADSKNAAQADKKNDQSSNSSNVPGAVEDLNKNLSRLVEGSDSSSSESESESDTNSDTEKEKEKTGKEPVKSLRKTLKKRLKKESSLKIISSSFDAAIQKRGKQLLSKFADIGHKVMLGVAVIREIVKVVTEMRMSLSGDLDMDTEEEMFLGYIFGAINSPPSSGAITPVGVSSEKDASDDPEKLDAPGLALKMRMLFGKEKPEVEGAIRSVLISQGMVDENLVVTRSRRNSFQEGQSGEEGLRSAMISQGMVYENLVITRSKRSSYQESGEEESKSTAAALRKFKSGEEEGFTSPDTAGERDETLEGTSFFNPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T4I0</accession>
    <name>A0A433T4I0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <ecNumber evidence="10">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_015771</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:15842"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="10"/>
    <dbReference type="EMBL" id="RQTK01000660">
        <property type="protein sequence ID" value="RUS76457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T4I0"/>
    <dbReference type="STRING" id="188477.A0A433T4I0"/>
    <dbReference type="OrthoDB" id="60984at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000013">
        <property type="entry name" value="Glucose-6-phosphate 1-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000111">
        <property type="entry name" value="Glucose-6-phosphate 1-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429:SF0">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="6 10" id="KW-0521">NADP</keyword>
    <keyword evidence="7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase NAD-binding" evidence="12">
        <location>
            <begin position="81"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase C-terminal" evidence="13">
        <location>
            <begin position="256"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS76457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="564" mass="64149" checksum="3426D715E8B8172C" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T7D5</accession>
    <name>A0A433T7D5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_014816</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000581">
        <property type="protein sequence ID" value="RUS77438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T7D5"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS77438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="122" mass="14226" checksum="C91110832D9E330C" modified="2019-05-08" version="1">MSANPPPPYTPRPETKYPEYPPPHHTGYPPPHHTGYPPPRHPGHPPPRHPVRPPPHHTVYAATEHTVYPRPMQGSRTVTVIQSHPSRTIFVEDRSVNHLLHFIIFLFFPVWIFVWIYCCLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T947</accession>
    <name>A0A433T947_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_014123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000532">
        <property type="protein sequence ID" value="RUS78115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T947"/>
    <dbReference type="OrthoDB" id="10631856at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS78115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="399" mass="43670" checksum="3547F20AA3B7E349" modified="2019-05-08" version="1">MPRTSFSSPLPNNTHSPGLGGQARQFLESPSDSRVPRTPSVPDRNVCVDQSVPLTPDNHRSSHPIFPAVFRTPNRTAPLSASTPPQTLLERHSPFHQEISPITTLQSLDQCVPSTPKDFYKSKLKWSSLSASSISPVPHFPAENVEVSTPTQNSQYVASTSFAESISPTVEHNASENLGESGYFSTSPDKGNDSYTRGKGRLVRSLTDSSRKKCSTDQYKSDPPRKRPPSSRRRLSLSLQGPKDVLRRAAHHNCAFQRSSTRDMCDAESTNSSITLQLKDSLEVDSSTEIFPLEDSDISSESRFSESVTRHSIVAETSGKCVNEHVALVSPAGDVSNVLLNHNPKLAFQNRINSPQALDTDNCPCPIIQYASRADEPGEGSGKNQPTPLDLFNDDNIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T996</accession>
    <name>A0A433T996_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCDC66 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_014061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000527">
        <property type="protein sequence ID" value="RUS78173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T996"/>
    <dbReference type="STRING" id="188477.A0A433T996"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039183">
        <property type="entry name" value="CCD66"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040467">
        <property type="entry name" value="CCDC66_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22736">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22736:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15236">
        <property type="entry name" value="CCDC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC66" evidence="2">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS78173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="107" mass="13423" checksum="998B0C87E0133E08" modified="2019-05-08" version="1" fragment="single">VDPVTRKEQEEKRRVHLEYQAEIKAQIEEKERQKKEERERKMREDIEEERKLQMERDKFNKQLEQEQRKLREKEEQKQKQIDALKSAIYEAQEKAMEEKTHKRIHHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T9Y2</accession>
    <name>A0A433T9Y2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_013817</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000511">
        <property type="protein sequence ID" value="RUS78403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T9Y2"/>
    <dbReference type="STRING" id="188477.A0A433T9Y2"/>
    <dbReference type="OrthoDB" id="5796379at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045179">
        <property type="term" value="C:apical cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008093">
        <property type="term" value="F:cytoskeletal anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045176">
        <property type="term" value="P:apical protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008356">
        <property type="term" value="P:asymmetric cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009786">
        <property type="term" value="P:regulation of asymmetric cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21966">
        <property type="entry name" value="INSC_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.200.10">
        <property type="entry name" value="Inscuteable LGN-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045789">
        <property type="entry name" value="Insc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031938">
        <property type="entry name" value="INSC_LBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038205">
        <property type="entry name" value="INSC_LBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039921">
        <property type="entry name" value="Inscuteable"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21386">
        <property type="entry name" value="INSCUTEABLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21386:SF0">
        <property type="entry name" value="PROTEIN INSCUTEABLE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19427">
        <property type="entry name" value="Insc_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16748">
        <property type="entry name" value="INSC_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein inscuteable homologue LGN-binding" evidence="2">
        <location>
            <begin position="19"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Protein inscuteable homologue C-terminal" evidence="3">
        <location>
            <begin position="74"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="1">
        <location>
            <begin position="259"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS78403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="517" mass="57293" checksum="EC09B3E58475A128" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TAL5</accession>
    <name>A0A433TAL5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_013643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000500">
        <property type="protein sequence ID" value="RUS78608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TAL5"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS78608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="203" mass="22748" checksum="DBA147E395893FE9" modified="2019-05-08" version="1">MVPRLTSDNFMCRYTQNRAEIQRTKVDKQICRPLDPNRDSPDPETNDPPLNAIIHHSEQTSQHPCHSNYAERKLPLGVNASQHRPRTSGTAASGCPAVSQYRLRMRGPASPGPPTPRTWAPRTDRVTPTWRSARGIVLTQVVKTELRFNSSISLTKQTWRIAWHHTQGRRAGDFAPDLTPMARKAKSRRKTSSADSGGPVDQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TCY9</accession>
    <name>A0A433TCY9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Enhancer of mRNA-decapping protein 4 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_012796</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000450">
        <property type="protein sequence ID" value="RUS79455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TCY9"/>
    <dbReference type="STRING" id="188477.A0A433TCY9"/>
    <dbReference type="OrthoDB" id="21128at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.100">
        <property type="entry name" value="conserved c-terminal region of ge- 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045152">
        <property type="entry name" value="EDC4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049404">
        <property type="entry name" value="EDC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044938">
        <property type="entry name" value="EDC4_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15598">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15598:SF5">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21289">
        <property type="entry name" value="EDC4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Enhancer of mRNA-decapping protein 4 C-terminal" evidence="5">
        <location>
            <begin position="174"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS79455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="301" mass="33437" checksum="CE18A29D2EB334AB" modified="2019-05-08" version="1">MDMLATSIGDVIYQHMQQAYTDSFRTAMLPSFKEALEKSVRDVHGIFQQGTKEYQLYMRQTADQMLKERNAADELVSRMELAEKQFVQSVAQMKTLIISSVKEELGGQVAHAVNSVKSEIVSDVKRLLREEMGQALQDHGASISDQLSTYLRSGAGTPVPFTSEEETNKEKILRELRSGRINDAFQFALSVGNIDMVVFACESARPMDIFAQNPFPLTQPVLLSLISQLSANLDKDFDLKIKYLEDAVMFLDPSQPTSSEHIPNVVGGLLSSLQSCDAHGGDPRKIKTIRMLIMAGKSLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TE16</accession>
    <name>A0A433TE16_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="15">PPIase</shortName>
            <ecNumber evidence="15">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EGW08_012469</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">EC2010</strain>
            <tissue evidence="17">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone.</text>
    </comment>
    <comment type="function">
        <text evidence="15">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cyclophilin-type PPIase family. PPIase H subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="15"/>
    <dbReference type="EMBL" id="RQTK01000429">
        <property type="protein sequence ID" value="RUS79753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TE16"/>
    <dbReference type="STRING" id="188477.A0A433TE16"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000017">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0697">Rotamase</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="16">
        <location>
            <begin position="9"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00059766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RUS79753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="173" mass="18976" checksum="837153FD809741A0" modified="2019-05-08" version="1">MQSGNPVVFFDIAIGSTDAGRIKMELFANVVPKTAENFRQLCTGEYKKDGKPIGYKGATFHRVIKDFMIQGGDFVNGDGTGMTSIYAGRPFADENFKMKHESPGILSMANSGKDTNGCQFFITCQKCDFLDNKHVVFGKVVDGHLVMRKIENVPVGPNNKPKIPVTISECGEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TG00</accession>
    <name>A0A433TG00_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_011724</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="RUS80503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TG00"/>
    <dbReference type="STRING" id="188477.A0A433TG00"/>
    <dbReference type="OrthoDB" id="114660at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FN3_sf"/>
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    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
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        <property type="entry name" value="FRAZZLED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="32"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="133"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="232"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="322"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="402"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="489"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="342"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="370"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="437"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="489"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="502"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="551"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="610"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="628"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS80503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="641" mass="72516" checksum="53353733D536EF76" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TGY9</accession>
    <name>A0A433TGY9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein heavy chain ATP-binding dynein motor region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_011420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000372">
        <property type="protein sequence ID" value="RUS80799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="188477.A0A433TGY9"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS80799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="25250" checksum="2FD2EFC94D90757F" modified="2019-05-08" version="1">MPPPTKSVAKPAPKPAPKTGVKGLPKAPAKAKPAGGASKAPASKAPAATTAAKKEPEPAKPAPIVITEVPFKQVDAKVVFDREGTVKASGKWAIAMDENALIGRFLRHRDVNMLSTPDNQQMQPETIRMALLGSIKFGKPFVIDMMESEMYEFIRDKFDEILPGLLDMVLDKSIIKDESYMKIVKESDGQEYQSRYDYNIEGFSFLIITSQLAPNEELLRKMYPVKVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TI00</accession>
    <name>A0A433TI00_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_011081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
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        <lineage>
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            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000352">
        <property type="protein sequence ID" value="RUS81173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="188477.A0A433TI00"/>
    <dbReference type="OrthoDB" id="5969565at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061564">
        <property type="term" value="P:axon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:sensory organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050359">
        <property type="entry name" value="bHLH_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290:SF163">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX NEURAL TRANSCRIPTION FACTOR TAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="208"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="486"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS81173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="593" mass="64366" checksum="449B6B9931627D8A" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TID6</accession>
    <name>A0A433TID6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_010880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000342">
        <property type="protein sequence ID" value="RUS81348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TID6"/>
    <dbReference type="STRING" id="188477.A0A433TID6"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24183">
        <property type="entry name" value="FIBRONECTIN TYPE 3 AND ANKYRIN REPEAT DOMAINS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24183:SF1">
        <property type="entry name" value="FIBRONECTIN TYPE 3 AND ANKYRIN REPEAT DOMAINS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="45"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="78"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="111"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="144"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="177"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="210"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="242"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS81348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="315" mass="33774" checksum="02CE2302608E4D14" modified="2019-05-08" version="1">MSLKVGKKETPSDQQLHLAALQGNVEQLKATLDSGRVHVDCKDKEGTTPLILAAANNHLECVKELLEQGADPNARRLTGTCALFFASQGGFLDVVKILLEYSANVDLSSFDGGTPLFVACQCNHQDVVAELLARGADIHAQMIDGATALFITAQNGHAELLKFLLLKGADPQMKRKDKASPLWIASQMGHTAVVRELLNAGAEVDAVREDGATPLFKACHKGHLDTISELLKHSPNVGVLKNGETVLHAAALFGHLKAVRLLLQSGIKADVKNAEDQTAAELAQDAGFDFIATFINNFTQEQDAEKEPKAAEADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TIP7</accession>
    <name>A0A433TIP7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase M12B propeptide domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_010765</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000336">
        <property type="protein sequence ID" value="RUS81467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TIP7"/>
    <dbReference type="STRING" id="188477.A0A433TIP7"/>
    <dbReference type="OrthoDB" id="2131567at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002870">
        <property type="entry name" value="Peptidase_M12B_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01562">
        <property type="entry name" value="Pep_M12B_propep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018986289" description="Peptidase M12B propeptide domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B propeptide" evidence="3">
        <location>
            <begin position="28"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS81467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="134" mass="15033" checksum="C1530E294599E394" modified="2019-05-08" version="1" fragment="single">MAVLKVLAFLCCFPCVTAELSERLRYFETVHHVNVRVRSRRSADRPHLEIKDVSFTALGRKFDLMLTPGTPVVGSDFSAKVVHGDGSSSNLYVNLNNFYNGHLAGDESVKADAFMEDGIWTANIYDKDEIYTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TLX5</accession>
    <name>A0A433TLX5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="4">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_009735</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="RQTK01000283">
        <property type="protein sequence ID" value="RUS82521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TLX5"/>
    <dbReference type="STRING" id="188477.A0A433TLX5"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45570:SF2">
        <property type="entry name" value="ACETYLCHOLINESTERASE 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45570">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="97"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="47"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS82521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="658" mass="73481" checksum="DFA6D9A666D06586" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TMD9</accession>
    <name>A0A433TMD9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">A to I editase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_009528</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000275">
        <property type="protein sequence ID" value="RUS82691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TMD9"/>
    <dbReference type="OrthoDB" id="10268011at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003726">
        <property type="term" value="F:double-stranded RNA adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008251">
        <property type="term" value="F:tRNA-specific adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006382">
        <property type="term" value="P:adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002466">
        <property type="entry name" value="A_deamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10910:SF107">
        <property type="entry name" value="DOUBLE-STRANDED RNA-SPECIFIC ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10910">
        <property type="entry name" value="EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02137">
        <property type="entry name" value="A_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00552">
        <property type="entry name" value="ADEAMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50141">
        <property type="entry name" value="A_DEAMIN_EDITASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="3">
        <location>
            <begin position="702"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="A to I editase" evidence="4">
        <location>
            <begin position="842"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="415"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS82691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1085" mass="120769" checksum="D09ACB144E16B0BD" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TQX6</accession>
    <name>A0A433TQX6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Exostosin-2</fullName>
            <ecNumber evidence="6">2.4.1.224</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">EGW08_008367</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">EC2010</strain>
            <tissue evidence="23">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyltransferase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.224" evidence="6"/>
    <dbReference type="EMBL" id="RQTK01000226">
        <property type="protein sequence ID" value="RUS83886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TQX6"/>
    <dbReference type="STRING" id="188477.A0A433TQX6"/>
    <dbReference type="OrthoDB" id="5954868at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050508">
        <property type="term" value="F:glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015012">
        <property type="term" value="P:heparan sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000035">
        <property type="entry name" value="Putative Exostosin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004263">
        <property type="entry name" value="Exostosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040911">
        <property type="entry name" value="Exostosin_GT47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015338">
        <property type="entry name" value="GT64_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261">
        <property type="entry name" value="ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261:SF5">
        <property type="entry name" value="EXOSTOSIN GLYCOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03016">
        <property type="entry name" value="Exostosin_GT47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09258">
        <property type="entry name" value="Glyco_transf_64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="18" id="KW-0464">Manganese</keyword>
    <keyword evidence="15 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Exostosin GT47" evidence="21">
        <location>
            <begin position="109"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase 64" evidence="22">
        <location>
            <begin position="458"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00069568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF03016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF09258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="RUS83886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="719" mass="82561" checksum="6892B8B0931FC24A" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TRJ6</accession>
    <name>A0A433TRJ6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reelin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_008026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000213">
        <property type="protein sequence ID" value="RUS84222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TRJ6"/>
    <dbReference type="OrthoDB" id="6109395at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019256077" description="Reelin domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS84222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="19141" checksum="C615D59B33F614B9" modified="2019-05-08" version="1">MAALFVYSVALLTLCSGSRVVFRQDPVRVAEVLTKTLRLRCALEDSGAQVTPTSAPVSGMTLLAVGTQTAQYVDTITSIEITRDGERLAFLDQNSTYPQAEGDYSNLKVIGDLSLPQTLSERAFLELTWSAPSYNQSGEYTCIINATTSPSGGMFNFEVMAEMESSSRQNKTWSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TSA9</accession>
    <name>A0A433TSA9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">15-oxoprostaglandin 13-reductase</fullName>
            <ecNumber evidence="2">1.3.1.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">15-oxoprostaglandin 13-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_007761</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>13,14-dihydro-15-oxo-PGF2alpha + NADP(+) = 15-oxoprostaglandin F2alpha + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133374"/>
            <dbReference type="ChEBI" id="CHEBI:133409"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="6">
            <dbReference type="Rhea" id="RHEA:50590"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+) = 15-oxoprostaglandin E1 + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57401"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133408"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:50586"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+) = 15-oxoprostaglandin F1alpha + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50592"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:79072"/>
            <dbReference type="ChEBI" id="CHEBI:133411"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="5">
            <dbReference type="Rhea" id="RHEA:50594"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADP-dependent oxidoreductase L4BD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.48" evidence="2"/>
    <dbReference type="EMBL" id="RQTK01000204">
        <property type="protein sequence ID" value="RUS84465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TSA9"/>
    <dbReference type="STRING" id="188477.A0A433TSA9"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047522">
        <property type="term" value="F:15-oxoprostaglandin 13-reductase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006693">
        <property type="term" value="P:prostaglandin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF5">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="22"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS84465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="352" mass="38185" checksum="E0D1E34E379D98A2" modified="2019-05-08" version="1">MSSNSKNFHIVLTSRPGETNAATESNFGYEETTYPDEPTVEGILLVKNIYLSLDPALRCRLNNGTGVDYIGPWEIGKTADGFGGIGEVISSKDPGFKAGDLIVPNFLWPWKLYFTIEAVAVRKITTENMNWSPTLYLSVFGLTGLTAYLGVKEKGHVAKGANQTMVVSAAAGSTGSFAGQIAKAMGCGKVVGTCGSQEKVKCLTEELGFDAAINYKTESLPDRLKVLCPNGIDIYFDNVGGQTTNDIIQQMNENSHIILCGQIADYNKTIEYPPPLPKEISDILKTKNITRDRFLVLTYKDQFAEATAALMEMYGTGKIKVKETIETGLENAGKAFVSMMNGGNIGKQLLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TVT0</accession>
    <name>A0A433TVT0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_006588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000163">
        <property type="protein sequence ID" value="RUS85642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TVT0"/>
    <dbReference type="STRING" id="188477.A0A433TVT0"/>
    <dbReference type="OrthoDB" id="8963449at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS85642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="125" mass="14207" checksum="C22835958CAF116C" modified="2019-05-08" version="1" fragment="single">TDTNRERGVRSDTNRERGVGADKNRERGVKADTNRERGVKADTNRERGLRVGTNRERGVGTGTNRERGVKADTNRERGVRADTNRERCVKADTNRERCVKADTNIERGVKADTNRERWVGADKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TYF7</accession>
    <name>A0A433TYF7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_005608</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000133">
        <property type="protein sequence ID" value="RUS86592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TYF7"/>
    <dbReference type="STRING" id="188477.A0A433TYF7"/>
    <dbReference type="OrthoDB" id="5586at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21504">
        <property type="entry name" value="PPP2R3A_B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.220:FF:000001">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000628">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.230:FF:000001">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041534">
        <property type="entry name" value="EF-hand_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048855">
        <property type="entry name" value="P2R3A_B_D_EF-hand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14095:SF0">
        <property type="entry name" value="MIP22305P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14095">
        <property type="entry name" value="PHOSPHATASE 2A REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17958">
        <property type="entry name" value="EF-hand_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21161">
        <property type="entry name" value="P2R3B_EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="412"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="27"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="573"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00093310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS86592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="611" mass="68391" checksum="BFFC03AF015B1BCD" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TZE0</accession>
    <name>A0A433TZE0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_005267</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000123">
        <property type="protein sequence ID" value="RUS86942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TZE0"/>
    <dbReference type="STRING" id="188477.A0A433TZE0"/>
    <dbReference type="OrthoDB" id="10249393at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="166"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS86942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="689" mass="77820" checksum="AACC401C4D5FBC52" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TZK1</accession>
    <name>A0A433TZK1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_005244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000122">
        <property type="protein sequence ID" value="RUS87006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TZK1"/>
    <dbReference type="STRING" id="188477.A0A433TZK1"/>
    <dbReference type="OrthoDB" id="10069709at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS87006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="172" mass="18419" checksum="48B5B207623F7A8B" modified="2019-05-08" version="1" fragment="single">SIQDREGASIQDREGASIQDREGASIQDREGASIQDREGAGIQDREGASIQDREGASIQDREGASRQDREGASIQDREGASIQDREGASIQDREGASIQDREGASIQDREGASIQDREGASIQDREGASIQDREGASIQDREGASIQDREGASIQDRAGASIQDREGARTHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TZY5</accession>
    <name>A0A433TZY5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">YEATS domain-containing protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EGW08_005133</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">EC2010</strain>
            <tissue evidence="15">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Chromatin reader component of the NuA4 histone acetyltransferase (HAT) complex, a complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. Specifically recognizes and binds acylated histone H3, with a preference for histone H3 diacetylated at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac) or histone H3 diacetylated at 'Lys-14' and 'Lys-27' (H3K14ac and H3K27ac). Also able to recognize and bind crotonylated histone H3. May also recognize and bind histone H3 succinylated at 'Lys-122' (H3K122succ); additional evidences are however required to confirm this result in vivo. Plays a key role in histone variant H2AZ1/H2A.Z deposition into specific chromatin regions: recognizes and binds H3K14ac and H3K27ac on the promoters of actively transcribed genes and recruits NuA4-related complex to deposit H2AZ1/H2A.Z. H2AZ1/H2A.Z deposition is required for maintenance of embryonic stem cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of numerous complexes with chromatin remodeling and histone acetyltransferase activity. Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC and the adenovirus E1A protein. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. Interacts with MLLT10/AF10. Also interacts with the SWI/SNF component SMARCB1/BAF47, TACC1 and TACC2, and the nuclear matrix protein NUMA1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000119">
        <property type="protein sequence ID" value="RUS87133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TZY5"/>
    <dbReference type="STRING" id="188477.A0A433TZY5"/>
    <dbReference type="OrthoDB" id="16041at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16909">
        <property type="entry name" value="YEATS_GAS41_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1970:FF:000002">
        <property type="entry name" value="YEATS domain-containing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47573">
        <property type="entry name" value="PROTEIN AF-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47573:SF1">
        <property type="entry name" value="PROTEIN AF-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="1" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="YEATS" evidence="14">
        <location>
            <begin position="11"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00064752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RUS87133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="226" mass="26155" checksum="C5ED56D14B2A6D37" modified="2019-05-08" version="1">MTTQAQDSAGRQKGVVVVKPVVYGNIARYFGKKREEDGHTHQWTVYVKPFNNEDMSAYVKKINFKLHDSYPSPNRIVTKPPYEVTETGWGEFEIIIKIYFNDPQERPVTIYHLLKLFQSETDVMLGKKSLVVEYYDEMVFQDPTVTMTSMLANTTSLGVSTHKHETDFEDKKERTINKISNAHGKIRYEIDQMNEKLKKSKDAISKMKKEISKLEEGVIMDTDIMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U1X4</accession>
    <name>A0A433U1X4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_004460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000101">
        <property type="protein sequence ID" value="RUS87795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U1X4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS87795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="252" mass="27437" checksum="198E54D8503C50CF" modified="2019-05-08" version="1">MSLNLIRKDTRLKVRDGSPRCVPKQLIEDHKTRASVAESPSKRVQEERGALAWPGGDHRLKDHSECFLDHMIAGDKTWSPCPVTVTSRPGMFSWRQLLKINQLALATSVLVGGGGGGGGDDDDDDDDDDDDDDDDDDDDDDDDYGDDYIVRDSDRDRDYVKQICSASNFVQSPVSLVSSVSTPDPPDPLVNTVGPPDPCADRSVDKLGPGETISLLPLINGGYPRGSTSRDARSKDNFCGRSCQSIRQTITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U217</accession>
    <name>A0A433U217_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-serine ammonia-lyase</fullName>
            <ecNumber evidence="6">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_004349</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="6"/>
    <dbReference type="EMBL" id="RQTK01000098">
        <property type="protein sequence ID" value="RUS87871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U217"/>
    <dbReference type="STRING" id="188477.A0A433U217"/>
    <dbReference type="OrthoDB" id="4418812at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030378">
        <property type="term" value="F:serine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018114">
        <property type="term" value="F:threonine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070179">
        <property type="term" value="P:D-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050">
        <property type="entry name" value="SERINE / THREONINE RACEMASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050:SF1">
        <property type="entry name" value="SERINE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="11">
        <location>
            <begin position="38"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS87871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="337" mass="37568" checksum="56FFA0E41C742F2A" modified="2019-05-08" version="1">MLICRFQYCSAVLFGSSIAMEQLGVVYSDVLSARDKIAPYIHETPVLTSAQADEKTGRKLFFKCENYQKTGSFKARGALNAVTHSSGNHGQALSWATQVAEFPCYVVVPQTAPEQEIEVKKRAIRGYGGRLVECGPDLQERYDTCEKLVREKELLAISSSDHADVIAGQVRDHWTLLLLLQAYIFLLFIILIYIYTFFLCFNGFVSLIVILPLFSVFLATPKGKSLEQCLRTGERPWKGPRQYLNTVADGLRLEQTGYINTPILVALAEKDVFEMGDEEIVAAMKFAFERMKMVVEPSGATPLAAAFSKKFQTMDSKLVNIGVVLSGGNVDIDHLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U2N4</accession>
    <name>A0A433U2N4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_004134</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000093">
        <property type="protein sequence ID" value="RUS88081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U2N4"/>
    <dbReference type="STRING" id="188477.A0A433U2N4"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045597">
        <property type="term" value="P:positive regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050941">
        <property type="entry name" value="CCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11348:SF17">
        <property type="entry name" value="CCN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11348">
        <property type="entry name" value="CONNECTIVE TISSUE GROWTH FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01208">
        <property type="entry name" value="VWFC_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="5">
        <location>
            <begin position="114"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="3">
        <location>
            <begin position="203"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="3">
        <location>
            <begin position="288"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="3">
        <location>
            <begin position="427"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="3">
        <location>
            <begin position="583"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="5">
        <location>
            <begin position="1020"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="1020"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS88081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1093" mass="115880" checksum="3399FA25B14580FC" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U2X8</accession>
    <name>A0A433U2X8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arginine-hydroxylase NDUFAF5, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Putative methyltransferase NDUFAF5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_004057</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000091">
        <property type="protein sequence ID" value="RUS88160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U2X8"/>
    <dbReference type="STRING" id="188477.A0A433U2X8"/>
    <dbReference type="OrthoDB" id="16816at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050602">
        <property type="entry name" value="Malonyl-ACP_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090:SF1">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="7">
        <location>
            <begin position="111"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="359"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00040937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS88160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="404" mass="45853" checksum="7EA948E878F4B474" modified="2019-05-08" version="1">MFTTNIMPPLQKFGNWTFSHYKTVRAYSYSVNKLLMGQGRKQSCDRFYRCMNTQGSIMNVFDRKAKRMQKERAALGHGGEDPSVYDYIKDEFGYRLSDRICDIKRKFKLVVDLGCGRGQHWFVEMLLYQLTIYQCDMSPSMLEQAATSTDVPSHKMVVDEEYLPFEENSVDLVVSNLSLHWVNNLPGSLAQIRHILKKDSPLVGSMFGGDTLYQLRVSLQLAEIEREGGFAPHISPFTTVSDLGNLMNRAGFTMLTIDIDDVAVTYPSMFELMQDLKGMGENNCSWSRKPQLHRDTMIAAASIYQAMYGNENGVPATFQVINFIGWKPDPSQPKPAERGSGEVSLKDLHRVEDLTKQIKDLREETGVPSEKADSLSKAAKKLEQDIQKAAKLHTERESDDPKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U6E1</accession>
    <name>A0A433U6E1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_003001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000061">
        <property type="protein sequence ID" value="RUS89258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U6E1"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012332">
        <property type="entry name" value="Autotransporter_pectin_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40380:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40380">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="60"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="307"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS89258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="957" mass="101502" checksum="EC84FB97574CDAD9" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U851</accession>
    <name>A0A433U851_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_002246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000043">
        <property type="protein sequence ID" value="RUS89979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U851"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS89979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="234" mass="25448" checksum="3BD3E58C0CF3EAD2" modified="2019-05-08" version="1">MRQVRANLEGLLDVRAGVGFVGPKSPMRGLRFLTKINTTAQSAVQKSLEQASQVLQMLFSTDSAHEDVVQLYWLRVRAHLTSLVAVLAQGESPPHKSGSCIGSGKLRLDSLVLGVGILVMVSALSLSKLRLWGGSAINTRRGAGQRNIFFQTTAQSAVLKSLEQASQVLQMLFSTDSAHGDVVQKSWHPQSVETVEVAPSLQIGDIKLRGKKGELVETERWSHLPSKLQSDKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UC94</accession>
    <name>A0A433UC94_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cysteine and tyrosine-rich protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_000718</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000010">
        <property type="protein sequence ID" value="RUS91497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UC94"/>
    <dbReference type="OrthoDB" id="10619071at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026910">
        <property type="entry name" value="Shisa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31395:SF23">
        <property type="entry name" value="GEO05642P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31395">
        <property type="entry name" value="SHISA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019348492" description="Cysteine and tyrosine-rich protein 1" evidence="7">
        <location>
            <begin position="22"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="128"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS91497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="19922" checksum="7A731892984CB8EB" modified="2019-05-08" version="1">MANMLWIFAFCLASVLHASNAEEMCGYKYCEHGCCDYSSSECCDEVNVAAIIGLVVGVIVVIVFIVIIIIVCRRRRHNGIVYRSQPGNQTVVVQQGVSANNGFVTQGMQPGVVYPPYQPYAPQPGYPQPMMGQAYPPPAPGQAYPPPTHAQGPPSYESLQQDNPPQAYPGASGGLDNRGFNEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z9J8</accession>
    <name>A0A3S0Z9J8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_018387</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000894">
        <property type="protein sequence ID" value="RUS73843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z9J8"/>
    <dbReference type="STRING" id="188477.A0A3S0Z9J8"/>
    <dbReference type="OrthoDB" id="9990906at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="63"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS73843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="374" mass="41359" checksum="9AFBDD4CFD1B6750" modified="2019-04-10" version="1">MRCFKVGDTTPEFGLLFSNSSVFKNLSSNRALSMDENLDSEFSSVMEFISYAMICVALCGILGNILVIITYAKIGLSESINISYCALGVSDLLVVLSIAWGAVCYVPAFIESDVPFLPRQVVIITGDACIEMFGSCTAWLTAFISLERCLCVLLPLKFKDIITWRRSILIILTIFTLTIASFLGVYLNLYSFETTFAIERNETVLGFEFQNSTDADLLYDFSLAFSAVVMNLLPVTFIFVCSTTLVVNMRRKATWRLSATSQATGQNGAGGSDNRARRNYMADMRVSKTVLAICAASCVLGSLFALRSLLAVTVSGFLPTEVYGPEYRMSSRLLFLLSGVNSSFNVAIYYKTGSTFRATTRRLFRLKDTENARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z9Y1</accession>
    <name>A0A3S0Z9Y1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_022135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001490">
        <property type="protein sequence ID" value="RUS70110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z9Y1"/>
    <dbReference type="STRING" id="188477.A0A3S0Z9Y1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS70110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="104" mass="11982" checksum="7B8287DCF97415FA" modified="2019-04-10" version="1" fragment="single">FKYTPTPLSLLGRFEYTPSPLSLLERFEYTPSPLSLLERFEYTPSPLSLLERFEYTPSPLSLCERFKYTPSLLSLCGRFKYTPNPLSLLGRFSYTPSPLSLCGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZAL9</accession>
    <name>A0A3S0ZAL9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="13">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">EGW08_017697</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">EC2010</strain>
            <tissue evidence="18">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 20">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="13"/>
    <dbReference type="EMBL" id="RQTK01000821">
        <property type="protein sequence ID" value="RUS74549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S0ZAL9"/>
    <dbReference type="OrthoDB" id="98077at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05052">
        <property type="entry name" value="PTKc_Abl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09935">
        <property type="entry name" value="SH2_ABL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11850">
        <property type="entry name" value="SH3_Abl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000010">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000037">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000004">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.330">
        <property type="entry name" value="Nucleotidyltransferases domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035837">
        <property type="entry name" value="ABL_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015015">
        <property type="entry name" value="F-actin-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08919">
        <property type="entry name" value="F_actin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 11" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 13" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH3" evidence="16">
        <location>
            <begin position="48"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="15">
        <location>
            <begin position="115"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="230"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="491"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="679"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="804"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1152"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1245"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="679"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="689"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="733"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="804"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="826"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="894"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="904"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="925"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="960"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="989"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1015"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1067"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1091"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1153"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RUS74549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1379" mass="149111" checksum="5F49F3042CA35C43" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZHG1</accession>
    <name>A0A3S0ZHG1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ADAM cysteine-rich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_017248</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000780">
        <property type="protein sequence ID" value="RUS74981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZHG1"/>
    <dbReference type="STRING" id="188477.A0A3S0ZHG1"/>
    <dbReference type="OrthoDB" id="6156443at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006586">
        <property type="entry name" value="ADAM_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF200">
        <property type="entry name" value="ADAM METALLOPEPTIDASE WITH THROMBOSPONDIN TYPE 1 MOTIF B, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00608">
        <property type="entry name" value="ACR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADAM cysteine-rich" evidence="8">
        <location>
            <begin position="21"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS74981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="128" mass="13923" checksum="849239F1D944D43C" modified="2019-04-10" version="1" fragment="single">SGQASCLLDRPAHQEALPKHLPGVLYDADDQCRLWLGTRHFPHSDMCGQLWCESPSDPHRAVKAAAPMMDGTMCGDRKYCINAQCVDIGPDGPIAVDGAWSDWPSDWSPCSRTCGGGVKKKVRVCDNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZLC3</accession>
    <name>A0A3S0ZLC3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CARD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_010593</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000326">
        <property type="protein sequence ID" value="RUS81630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZLC3"/>
    <dbReference type="STRING" id="188477.A0A3S0ZLC3"/>
    <dbReference type="OrthoDB" id="6162777at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070513">
        <property type="term" value="F:death domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01671">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037939">
        <property type="entry name" value="CRADD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15034">
        <property type="entry name" value="DEATH DOMAIN-CONTAINING PROTEIN CRADD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15034:SF5">
        <property type="entry name" value="DEATH DOMAIN-CONTAINING PROTEIN CRADD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00619">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00114">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50209">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CARD" evidence="2">
        <location>
            <begin position="128"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS81630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="385" mass="43932" checksum="96AD8292A66A0D5D" modified="2019-04-10" version="1" fragment="single">MSEKDRSQGSLEDIEEQIRKLEREKEELERINERKRLEQRLQLLQGNVTQLKSGSSSKDNQSSGKNQASRGRDSGDLNTSLEESQARLRSLQQSVLNSSLGGASSLADDSQEDHNRSSDDADQLDDVMSATHKQALRIHRDVLVENMTPDDIFNDLISKHILTNSDVSRIKEKNTTEAINEELLNVLIRRSEKAFYVFVSSLRRTLQGWLANRLDPISQPTNKRRRRTGEMNVNIDCERVVPARSKRSTCTCQEVEEQILLMAKGAFAHIRRRDASPAAFEQFRKEIQQTNIVIKESMEIRNTLKELCRHGDLVDLSEGSVCFTLRCTSLTSCQELWDRYISGCLLGIFQKHLVNPFLLKTCGAQEIHLCLRISRIEFLTCAIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZMD4</accession>
    <name>A0A3S0ZMD4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_009852</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000288">
        <property type="protein sequence ID" value="RUS82400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZMD4"/>
    <dbReference type="OrthoDB" id="6146345at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="4">
        <location>
            <begin position="88"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS82400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="240" mass="27644" checksum="BE119C1A81085FB1" modified="2019-04-10" version="1" fragment="single">MDPVMNGKEDSANASKDEEAVFDPIGTFEVPTDDADRVEPRPEDPYGFPYRWLSSGIYVNGVPVFRCPVKIPPATHIRKMMALPMRESDVVLAGFVKSGNHWMVEILHMLTAGSTEYSSRLKEHDQLEFVNDLDSLEALPSPRVLNTNVYMAHLPQEIAHKRVKIVHVLRNPKDTIVSLYFHMKQKAKSNFTLDNLIKGYVQDFYLYASHQFDFLRQMDEYIKAHPGHPVMHVQYEDLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZNJ2</accession>
    <name>A0A3S0ZNJ2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Thiolase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_010208</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000308">
        <property type="protein sequence ID" value="RUS82017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZNJ2"/>
    <dbReference type="STRING" id="188477.A0A3S0ZNJ2"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000010">
        <property type="entry name" value="Acetyl-CoA acetyltransferase (Thiolase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF107">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE, CYTOSOLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="7">
        <location>
            <begin position="4"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="8">
        <location>
            <begin position="271"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="5">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS82017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="41138" checksum="390F205E421D54E8" modified="2019-04-10" version="1">MVDVVILSAARTPVGSFNGSLASLAAHELGGIAIKEALNRANIKGNEVSEVILGQVLTAGQGQNPARQASAKGGIPFSVPACGVNMLCGSGLRSVVLAYQAICSGDSNIVVAGGQESMSKAPHCVHMRSGLKFGDGTLTDTMMTDGLTDAFHNYHMGITAENVVKQWSLTREEQDKFALNSQLKCEKAQREGCFKAEIVPVSVPSRAGPIEVATDEYPRSGSTFEAFQKLRPAFVKDGTGSVTAGNASGLNDGAAALVLTSGQEAQKRGIQPMARVVAWAQEGVDPSIMGTGPIPATRKALSKANWKMEDVDLFEINEAFAGQSLAVVKTLGCDPEKVNVNGGAIAIGHPIGASGARILTTLLYALQARNKRRGVAALCVGGGMGIALCVENMQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZNT4</accession>
    <name>A0A3S0ZNT4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_008849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000245">
        <property type="protein sequence ID" value="RUS83383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZNT4"/>
    <dbReference type="STRING" id="188477.A0A3S0ZNT4"/>
    <dbReference type="OrthoDB" id="336747at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS83383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="172" mass="19592" checksum="503724DEA6F6025A" modified="2019-04-10" version="1" fragment="single">HTNNIIHRDLKPHCILLASTENSAPVKLGGFGVATHLADGEHITSGRVGTPQYMSPEIIERRPYGKPVDMWGCGVLLFILLGGYPPFTGTKDRLYSIIVRGSFHMKPKQFDHISPMGKDLLMRMLEPDPAKRITVDQALEHAWIKNKKEVPRLHLHETVEELKKFNQRRKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZRA3</accession>
    <name>A0A3S0ZRA3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_007356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000190">
        <property type="protein sequence ID" value="RUS84887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZRA3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS84887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="121" mass="14566" checksum="73A0B227E60EAD8C" modified="2019-04-10" version="1">MIRDRVMDMVGDRDMVMGRVRAMVRVRVRVRVRVRVSFRVRVRVKVRVRVRVRVSFRVRVRVRDRVGDMDMVMDRVRAMVRVRVRVRVRVRVRVRFRVRVRAMVPLGFGIWLGIGLGIGIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZRR1</accession>
    <name>A0A3S0ZRR1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Protein disulfide-isomerase</fullName>
            <ecNumber evidence="4 13">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EGW08_018482</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">EC2010</strain>
            <tissue evidence="15">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="4 13"/>
    <dbReference type="EMBL" id="RQTK01000904">
        <property type="protein sequence ID" value="RUS73745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZRR1"/>
    <dbReference type="STRING" id="188477.A0A3S0ZRR1"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000045">
        <property type="entry name" value="Disulfide-isomerase A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000107">
        <property type="entry name" value="Protein disulfide-isomerase 5-2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005792">
        <property type="entry name" value="Prot_disulphide_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01130">
        <property type="entry name" value="ER_PDI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF210">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10 11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Thioredoxin" evidence="14">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="14">
        <location>
            <begin position="110"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="14">
        <location>
            <begin position="447"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="11">
        <location>
            <begin position="147"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="11">
        <location>
            <begin position="497"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605792-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RUS73745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="587" mass="66761" checksum="FB6A30E40494DC9E" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZVA7</accession>
    <name>A0A3S0ZVA7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_016142</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NUSAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000687">
        <property type="protein sequence ID" value="RUS76111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZVA7"/>
    <dbReference type="STRING" id="188477.A0A3S0ZVA7"/>
    <dbReference type="OrthoDB" id="3258416at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040001">
        <property type="term" value="P:establishment of mitotic spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026756">
        <property type="entry name" value="NuSAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15874">
        <property type="entry name" value="NUCLEOLAR AND SPINDLE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15874:SF1">
        <property type="entry name" value="NUCLEOLAR AND SPINDLE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16006">
        <property type="entry name" value="NUSAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="281"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="281"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS76111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="438" mass="47317" checksum="D86E6F5D988596D3" modified="2019-04-10" version="1">MSKALVSAATKKSATPKLQDSATTTGKATPNSDASSPIKQPKKRRRTFELEEPTLGAANTPTSEPAVGGRQTRSGSRTNTPTDNGPTAKRQRRNTYDKSDSAAEGVSPGTASMIASMDASQDSAERKANLLSAIDRKIQSKAPTVAASPNGPTSQPSQIPRFMAYLASMKKEAQQQQRPVTPGSKDWTKIHKKAFSKFDSIDVYLEKKQQRKDLLSGSGKRLNSALPKVGNTKIARPVSKPQQTVKPFVPTVTSVKKMTFNFGATPRSQARNPQTGAKASVKSNAFSASTNTSRLVTPATNTARKSVGSTNRATPFKFTGGTTDSKLASTSASQKSAFDLKASLARPLSWKPHTGKLQPLDFNTTTAATSRPVDFNTTRTIAPADLKSRSRPVGRPSRQALAAKTRPTNVKDVRRVQQLDRRNNQKYIDMMRRRGLMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZWA7</accession>
    <name>A0A3S0ZWA7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Isobutyryl-CoA dehydrogenase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Acyl-CoA dehydrogenase family member 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">EGW08_004669</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">EC2010</strain>
            <tissue evidence="19">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Isobutyryl-CoA dehydrogenase which catalyzes the conversion of 2-methylpropanoyl-CoA to (2E)-2-methylpropenoyl-CoA in the valine catabolic pathway. To a lesser extent, also able to catalyze the oxidation of (2S)-2-methylbutanoyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2S)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48256"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57337"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:88166"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:48257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2-methylpropanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = 2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:44180"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57338"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62500"/>
            <dbReference type="EC" id="1.3.8.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:44181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>propanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = acryloyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:31287"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57367"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:31288"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000107">
        <property type="protein sequence ID" value="RUS87563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZWA7"/>
    <dbReference type="STRING" id="188477.A0A3S0ZWA7"/>
    <dbReference type="OrthoDB" id="10254877at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003853">
        <property type="term" value="F:short-chain 2-methyl fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01162">
        <property type="entry name" value="IBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000001">
        <property type="entry name" value="Acyl-CoA dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000001">
        <property type="entry name" value="Acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034178">
        <property type="entry name" value="IBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052547">
        <property type="entry name" value="Mito_Isobutyryl-CoADH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43831">
        <property type="entry name" value="ISOBUTYRYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43831:SF1">
        <property type="entry name" value="ISOBUTYRYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016578">
        <property type="entry name" value="HsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="6 15" id="KW-0274">FAD</keyword>
    <keyword evidence="5 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="18">
        <location>
            <begin position="50"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="17">
        <location>
            <begin position="164"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="16">
        <location>
            <begin position="269"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00076026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR634178-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RUS87563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="422" mass="46336" checksum="59643514DB7FFE7D" modified="2019-04-10" version="1">MATLFKRGHHMSRHAVNILSNTLRNNHSRLHKRGILTASCADPSNGLGVEQRQIQQMALDFAAKELAPNMIEWDEKEIFPLGTLREAAKLGFGAVYCKEEFGGTGLTRLDASVIFEALATGCCSTTAYISIHNMCAWMIDDFGNKELRAQWIPQLATMEKCSSYCLTEPGAGSDAASLSTTAKKDGSHYVLNGSKAFISGSGEADLYIVMCRTGEAGSKGVSCILVEKGTPGLSFAKKERKLGWNSHPARIVNFDECRVPVTNLVGSEGQGFNIAMKGLNGGRINVASCSLGAAYAALEQARDHMKIRKQFGKPIENFQYLQFRLAEMATQLVASRLMVRNAAVALDNKDANAVALCSMAKLFATEECFKICDYAMQIFGGYGYLKDYPVQQYMRDSRVHCILEGTNEIMRLLVSRDLLTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZZ45</accession>
    <name>A0A3S0ZZ45_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_005630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000133">
        <property type="protein sequence ID" value="RUS86614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZZ45"/>
    <dbReference type="STRING" id="188477.A0A3S0ZZ45"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051262">
        <property type="entry name" value="SMP-30/CGR1_Lactonase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47572:SF4">
        <property type="entry name" value="LACTONASE DRP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47572">
        <property type="entry name" value="LIPOPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="2">
        <location>
            <begin position="104"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS86614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="367" mass="40540" checksum="01E296C63340AAC8" modified="2019-04-10" version="1" fragment="single">VFLGHVVVSISSYPQTSKKLYIQSWPTGSIFVWEWEFARTIFESLSLTVSLLVTVIVHTTMSTIITPLFNKIVEDIKGAEGPVFDLKGNFYMVAPEVEKDGKAAGQILKVDLSSKQVEIVCEPNIDGDGGIPAGCQVDKDGNLYVADMRLGILYVKPDGTYTQIARKDAGGRTMQGCNDCALDYDGNLWFTAPAGEIAPSPYLRSFEEPFGSIYCRTADGTIIHLESNYRFSNGLAVRHSKDGRPEKLIVAETPARLLWCYDIEGPGKITNKTQWGKLPDPGCTSGPDGMDFDEQGNLLVAHWGSSFIEVFGPDGGDPIRRIQCPFDKPSNLHFKPGSNLVLVTEHTNHGLWEFEWECKGMPQFCET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A101</accession>
    <name>A0A3S1A101_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_000591</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000008">
        <property type="protein sequence ID" value="RUS91618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A101"/>
    <dbReference type="OrthoDB" id="6161016at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS91618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="331" mass="36241" checksum="31F60B06388A0239" modified="2019-04-10" version="1" fragment="single">HSKSESSRSLKLSVYVSFPAGSNVTSGGSTTVQLPLAALKVILKASRDSVKSNIDMYITYIGSDYYGIPPESTANGIIIPIAAVTVVAVGISAVVMVYFQETREKKERAAARLARKRALKTLPNYNIQEVPHTSEVPTGIPGEPSGDTQPTENHNQSHDSQALNNNHALKKRFEPPTRTTGTSSPVNYFHSNGNVGNSATLPPLSSGSVMANTTTTTTTGSTAATTTTILPSNIHGAQYQQDQGQLQQNASFEESEEDKKKRRKKEKKREKKRLLQQQRQEQLRELEQGGLELHDQRDFDTSAMTVSETGATPRDMDNIPTFTVQRREELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A1T0</accession>
    <name>A0A3S1A1T0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_000511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000007">
        <property type="protein sequence ID" value="RUS91685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A1T0"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS91685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="108" mass="13438" checksum="545EFB1DF8896415" modified="2019-04-10" version="1" fragment="single">IIYYPLWVLSIIYYLQWVSSIISYLLWVLFIISYLLWVLSIINYLQWVLTIISYLLWVLYIIYYFLCVLSIIYYLLRVLSIIYYLLRVLSIIYYLLRVLSIIYYLMRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A2G6</accession>
    <name>A0A3S1A2G6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_000036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000001">
        <property type="protein sequence ID" value="RUS92183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A2G6"/>
    <dbReference type="STRING" id="188477.A0A3S1A2G6"/>
    <dbReference type="OrthoDB" id="10057935at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027901">
        <property type="entry name" value="CFAP90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34444:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34444">
        <property type="entry name" value="LOC361192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15074">
        <property type="entry name" value="CFAP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS92183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="149" mass="17262" checksum="B2D333CD8931D32E" modified="2019-04-10" version="1">MDTESVKMADGPEGITVVTDTDVFFLNGRPCELSDYSHIPTNRLSIPKDRNCFNSERKEHYPGSRYDRLFTQVDGYNNKLHRDDREHAKSRGLTVNNEEKQKEVPTLSSTIYGHRLNLHVDHPDRKHVRIGHVQSEFYRRNGIPNSAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A5L2</accession>
    <name>A0A3S1A5L2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GH10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_008927</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000249">
        <property type="protein sequence ID" value="RUS83305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A5L2"/>
    <dbReference type="STRING" id="188477.A0A3S1A5L2"/>
    <dbReference type="OrthoDB" id="1650875at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.690">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003305">
        <property type="entry name" value="CenC_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF1">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02018">
        <property type="entry name" value="CBM_4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018607897" description="GH10 domain-containing protein" evidence="6">
        <location>
            <begin position="19"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="7">
        <location>
            <begin position="225"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS83305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="752" mass="84235" checksum="F4DD9A529B6CE7A0" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AQ74</accession>
    <name>A0A3S1AQ74_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha-macroglobulin receptor-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_023358</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001952">
        <property type="protein sequence ID" value="RUS68879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AQ74"/>
    <dbReference type="STRING" id="188477.A0A3S1AQ74"/>
    <dbReference type="OrthoDB" id="6359008at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.690">
        <property type="entry name" value="Alpha-macroglobulin, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009048">
        <property type="entry name" value="A-macroglobulin_rcpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036595">
        <property type="entry name" value="A-macroglobulin_rcpt-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF146">
        <property type="entry name" value="CD109 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07677">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01361">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49410">
        <property type="entry name" value="Alpha-macroglobulin receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-macroglobulin receptor-binding" evidence="2">
        <location>
            <begin position="3"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS68879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="151" mass="17718" checksum="49D2B19B0B87F178" modified="2019-04-10" version="1">MTSGLSVLEVDLPTGYVVMNDTLRNYVRSGAVPNLRRAEFYKRTVFYYFDFVDQSSTCVDLRADRWFPVANTTNHNRIRIYDYYEPGMHYTRLYTVEDLHMLNICLACGSYQCPYCPNFNAASLLGASFISWLTVLTVYLLWHQWMHRPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AQY2</accession>
    <name>A0A3S1AQY2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">EGW08_022654</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">EC2010</strain>
            <tissue evidence="18">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="RQTK01001630">
        <property type="protein sequence ID" value="RUS69584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AQY2"/>
    <dbReference type="STRING" id="188477.A0A3S1AQY2"/>
    <dbReference type="OrthoDB" id="238316at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2330:FF:000005">
        <property type="entry name" value="phenylalanine--tRNA ligase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000033">
        <property type="entry name" value="Phenylalanine--tRNA ligase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040724">
        <property type="entry name" value="PheRS_DBD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040586">
        <property type="entry name" value="PheRS_DBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040725">
        <property type="entry name" value="PheRS_DBD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003210">
        <property type="entry name" value="PRK04172.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF40">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18552">
        <property type="entry name" value="PheRS_DBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18554">
        <property type="entry name" value="PheRS_DBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18553">
        <property type="entry name" value="PheRS_DBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="17">
        <location>
            <begin position="227"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RUS69584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="495" mass="55926" checksum="9D3DAD3F93232F8B" modified="2019-04-10" version="1">MAELSETLLIELDQAGTVDSTQLAEKLGVNHQTVVGAIKSLQSLFNVIKVEEKQSKRWQLTDEGNSILQNGSHEAVLFQSIPQEGIPQAKLMASGPNAKVGFSKAMSAGWIAVDKKAEGGPKVIKKVESIEDVVQQCLEKISKLDLSGVTDAQKNEYKKRKLIVEVKEVSYSVSKGENFTTSVSKQQVDLTPEMISSGSWRTAQFKPFNFNTLGVPATTGHLHPLLKVREQFRQIFLEMGFSEMPTNNYVESSFWNFDALFQPQQHPARDEHDTFFMAEPATASAFPMDFLEKVKDVHSKGGYGSQGYRYDWKMEEAEKNILRTHTTAVSTRMLYKLAQEKEFRPVKYFSIDRVFRNENLDATHLAEFQQIEGVVADRGLTLGDLMGVINQFFQRLGMTKLRFKPAYNPYTEPSMEIFGYHDGLGKWVEIGNSGVFRPEMLRPMGLPEDVSVIAWGLSLERPTMIKYKVSNIRDLVGPKVNLKMVYENPLCRLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AU86</accession>
    <name>A0A3S1AU86_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_019996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001093">
        <property type="protein sequence ID" value="RUS72242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AU86"/>
    <dbReference type="OrthoDB" id="10519778at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS72242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="388" mass="43727" checksum="BC2E0C37019EB91B" modified="2019-04-10" version="1">MALTALDIIFNIVSFIGFVLVAAGFGTRIWFFSETDRWQFKCDLRTCCVRDIDPTPKLWTCWPIKDPPTVFRWGEVLASCGLGLWLPIAVCLLAARAKRCARQAGCLALCFLMVAGGLGVTGCRMMFNTAEESFIIAEVPGVSGYMVLWGFSLTLTGSTLASRWMIIKAVDRTLNILGKLLGFTAALLFLLLRAFLYRPLLANSHKCSPICMRLKPLREKIFSMCIRFVSLSQLSYYIISVRLKSGFIFAKRTLLPYASTVIHLLRRRFFPIFAFAVFALTAVLTFFKSKMAALCTFTVTRLVAVLIVCSPRLYAIVESLRPVLCDRTKLVKVTYQFVLRLRDTIVSYLVGLVKPSFDLTLKYFKMKTPKSRRMNITKSVTLNGVTVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AUL4</accession>
    <name>A0A3S1AUL4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_019635</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001044">
        <property type="protein sequence ID" value="RUS72600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AUL4"/>
    <dbReference type="STRING" id="188477.A0A3S1AUL4"/>
    <dbReference type="OrthoDB" id="7537227at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46043">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46043:SF13">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS72600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="630" mass="71208" checksum="1E05D8CE7BC01518" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AW21</accession>
    <name>A0A3S1AW21_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_018476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000903">
        <property type="protein sequence ID" value="RUS73765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AW21"/>
    <dbReference type="STRING" id="188477.A0A3S1AW21"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS73765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="224" mass="24209" checksum="DE246FEA727787E6" modified="2019-04-10" version="1" fragment="single">ISLYLVPNSCITTISLYLVPNSCITTISLYLVPNSCITTISLCLAPNYCITTISLYLAPNYCITTISLYLAPNYCITTISLCLIPNSCITIISLVPTSCITTISLYLVPTSCITTISLYLAPNFFPNSCITTISLYLVPNSCITTISLYLVPNSCITTISMYLVPNSCITTISLVPNYCITTISLVPNYCITTISLVPNSCITTISLCLAPNSCITTICLYLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AXJ9</accession>
    <name>A0A3S1AXJ9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_021330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001308">
        <property type="protein sequence ID" value="RUS70902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AXJ9"/>
    <dbReference type="OrthoDB" id="10645619at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1010">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS70902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="299" mass="33974" checksum="828D042B2BA03160" modified="2019-04-10" version="1">MEYKVRGRREGKHGEHGEKKGRRPEGIWYMATGAYTASDTKGTKTLFLTVEYHLPPASVINEQNISARCSGLLDKDDTLFWSITGGTGDVGYQYNPGDPNVLVEKEKEKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKNTVSVLTVSIVPDLQGATIACFLDYVPNHLTCLDNNDACEHSLSLHVVYLHERPKLTLNVSTLLHENDTVQASCFAYVGTWGNMRWALAIADNLFRLEPDDKRVQKVNGKPKPHRCTDCAITRMSFYPPLKSLTFVDRQVGQSVERSLTGKEDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B0Y5</accession>
    <name>A0A3S1B0Y5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_014974</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000594">
        <property type="protein sequence ID" value="RUS77260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B0Y5"/>
    <dbReference type="STRING" id="188477.A0A3S1B0Y5"/>
    <dbReference type="OrthoDB" id="6122380at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="126"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="674"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="674"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS77260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="790" mass="89824" checksum="F8E47B11761DE671" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B2B1</accession>
    <name>A0A3S1B2B1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_017871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000838">
        <property type="protein sequence ID" value="RUS74362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B2B1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS74362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="204" mass="22721" checksum="232DA42BDA942386" modified="2019-04-10" version="1" fragment="single">AAPAQVLQVGHQDQDRQEEQRDPGLPGLHYPWADVVHDEQHPDVRPDAPHARHHEHAELLCIGKGRDAVDAHGGDDEHVEGGAADDGERSQRVCGLLIVQARDGLHHGKQDLRGGRAERHQRQVGHRLVPDQHLGRTTYLSLHHFIFLRVPLADGSLSRCNHLYTAHEDVRGNGDTDEEVEESDAVEEAPEPLGPKILCWQQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B2I3</accession>
    <name>A0A3S1B2I3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_013906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000517">
        <property type="protein sequence ID" value="RUS78328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B2I3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS78328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="107" mass="11449" checksum="ED5038D38B5D3A01" modified="2019-04-10" version="1" fragment="single">SRTSLAVSRSAVPQCGPGAFHPPHAESIAEPLAGHIATAGGQLAVGLLAAKHLVQEVDVPRRQLERLDLTQLVRGQRRDDLPQLGERVVKRLSPLPLPHVGEDPLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B3Z0</accession>
    <name>A0A3S1B3Z0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_012950</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000460">
        <property type="protein sequence ID" value="RUS79295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B3Z0"/>
    <dbReference type="STRING" id="188477.A0A3S1B3Z0"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000003">
        <property type="entry name" value="Y+L amino acid transporter 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF528">
        <property type="entry name" value="AMINO ACID TRANSPORTER PROTEIN JHI-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="445"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS79295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="506" mass="54998" checksum="B456B9B8ADD87D0C" modified="2019-04-10" version="1">MAARQTQNSGDTTVDSLLTKRKDGKMPDDTPKVELKKRITLFHCVSIIVGIIIGAGIFVSPVGITVQVRSVGMSILMWFVVGVFNTLCALCFAELGACLPESGGEYIYIKRAWGDFPAFLCLWMNYLLITPVTAAASSLVFANYMLRPLFPDCEPPRDGIQLLAALIIALLVAINCHNVNWVTKLQAVITGSKLLALMMVIVIGFIWLGKGNTENFQGSFEGTDLSAGAIAFAFYSGSWAFGGWNYLSFLTEEVVDPHRNLPLGIMISMGIITAVYMLANVAYFAVLTPAEMLQSSAVAVTFLQRTVPGLAYVIPFLIALSVVGALNGGILSVSRLFYVAARNNHLPSIVSMITIKKSTPVPSLVSLLILVVIMQTFGNIFFLIEMMGFSLSIVLIMTFAGQVLLRWTEPGLLRPIKVPVVLPAVLIVFNVAIMCITVYQKPQESSIALVIIACGVPAYLLGTKKDKPKSVQRFIENFTETLQKLLIVTVQDSEDCEDGKDTGSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B7S9</accession>
    <name>A0A3S1B7S9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF547 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_014185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000536">
        <property type="protein sequence ID" value="RUS78046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B7S9"/>
    <dbReference type="STRING" id="188477.A0A3S1B7S9"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006869">
        <property type="entry name" value="DUF547"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051548">
        <property type="entry name" value="Grx-like_ET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34386">
        <property type="entry name" value="GLUTAREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34386:SF1">
        <property type="entry name" value="GLUTAREDOXIN-LIKE PROTEIN NRDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04784">
        <property type="entry name" value="DUF547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF547" evidence="1">
        <location>
            <begin position="87"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS78046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="290" mass="32721" checksum="1A7B740D9CF014B5" modified="2019-04-10" version="1">MSPSSGVSARCISCVPTSCSLCRKCFCYLIFDTANQLGELLRKMILKLYSVFLSEDGKQVDYKGMKASDEFKTYTNMTRELIRIDIKSASREEKIAFFVNIYNALVIHANIVKGPPSNMYSRYKFFNNSKYIIGGHPYSLQDIENGVLRGNRKGVGQFCNPFGKKDPRLEVALVTHEPLIHFGLVCGAKSCPPIKTYTAEDIYKELKVAAAAFLENSDGCQIDMSNQSIQLSSIFKWYKVDFGSNDKELLEFVADHMGEGQKLTDLQTLMKKGTYRLSFLPYDWSTNSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B8M2</accession>
    <name>A0A3S1B8M2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_014547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000560">
        <property type="protein sequence ID" value="RUS77682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B8M2"/>
    <dbReference type="OrthoDB" id="6160909at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS77682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="321" mass="33426" checksum="846E72AEE7FE4833" modified="2019-04-10" version="1" fragment="single">IEEVEKTAASTFTSQPRSGASTPRSRPRSGFINPTQYASLEESLEPTAASQSCSSPSSSSTSASSQAKQQMQQSHANTSSTPMETTTITTAVDASIPRSQNALTSTVPRPESSPAGKPDPAEQDVSSSSLRATAPSSQQVSNHSGSHVLGTVSPPDKSSGPHTELSGSQLMEKLTRLADATEVYQERRQKFTQGGDNPGTSKVGAVAPERGGASKVNIPSTSGRGGKREADPARYQTQPITVEEIRAADSLETVSAFRALVRKKSAVGALEQLSLVKQHVGYTYTPVITMTTATAPTASGQQPVAAVAAGKRAEVPQHLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B8Z3</accession>
    <name>A0A3S1B8Z3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein 26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_009559</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000276">
        <property type="protein sequence ID" value="RUS82656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B8Z3"/>
    <dbReference type="OrthoDB" id="10042902at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019169">
        <property type="entry name" value="Transmembrane_26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22168">
        <property type="entry name" value="TMEM26 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22168:SF7">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 26-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09772">
        <property type="entry name" value="Tmem26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="358"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="490"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="415"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="509"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="533"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS82656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="593" mass="63707" checksum="6881B0517DBB0B40" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BAN5</accession>
    <name>A0A3S1BAN5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">diphosphoinositol-polyphosphate diphosphatase</fullName>
            <ecNumber evidence="4">3.6.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_008386</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>diphospho-myo-inositol polyphosphate + H2O = myo-inositol polyphosphate + phosphate.</text>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. DIPP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.52" evidence="4"/>
    <dbReference type="EMBL" id="RQTK01000227">
        <property type="protein sequence ID" value="RUS83845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BAN5"/>
    <dbReference type="STRING" id="188477.A0A3S1BAN5"/>
    <dbReference type="OrthoDB" id="2011998at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034431">
        <property type="term" value="F:bis(5'-adenosyl)-hexaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034432">
        <property type="term" value="F:bis(5'-adenosyl)-pentaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008486">
        <property type="term" value="F:diphosphoinositol-polyphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901911">
        <property type="term" value="P:adenosine 5'-(hexahydrogen pentaphosphate) catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901909">
        <property type="term" value="P:diadenosine hexaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901907">
        <property type="term" value="P:diadenosine pentaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071543">
        <property type="term" value="P:diphosphoinositol polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04666">
        <property type="entry name" value="NUDIX_DIPP2_like_Nudt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000002">
        <property type="entry name" value="diphosphoinositol polyphosphate phosphohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047198">
        <property type="entry name" value="DDP-like_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629">
        <property type="entry name" value="DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629:SF0">
        <property type="entry name" value="DIPHOSPHOINOSITOL-POLYPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="11">
        <location>
            <begin position="17"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS83845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="149" mass="16928" checksum="0A1D92648EB38DBC" modified="2019-04-10" version="1">MKVRENGADERTYDPDGLTRRASCLCFRDDTEKEILLITSTSSSCKWLVPGGGINKGEEPQDAAVREAREEAGVVGVVGRLLGIFENKEKQTRTWVFALYVKQLEEHWAEAKIRKREWHNLAEAKRILQLHKPIQATYISVMDGTQKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BEN0</accession>
    <name>A0A3S1BEN0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SURF1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_010364</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Probably involved in the biogenesis of the COX complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Mitochondrion inner membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the SURF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000316">
        <property type="protein sequence ID" value="RUS81894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BEN0"/>
    <dbReference type="STRING" id="188477.A0A3S1BEN0"/>
    <dbReference type="OrthoDB" id="10040024at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06662">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002994">
        <property type="entry name" value="Surf1/Shy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427:SF2">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02104">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50895">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS81894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="293" mass="33437" checksum="B38744C5F2E7C184" modified="2019-04-10" version="1">MRSLLLFCRVICRKSSFRYLSKAAGGKPPRQVPREKPAVRKRSPGGGGYPLLIIPLTTFALGTWQIQRRTWKLNLIQELEEKMRAEPIPLPSNLEDLKNMEYRRVKVTGTFDHSKELFIGPRSNTNEPETMGSARATTVGVHVVTPFKLSDRDETILVNRGHVPFTARPPQLRKEGQVDGEVELIGIVRLSDKGNMFGNDPLKDGYWLTRNVDEMADIAETAPVFIDADLQSTVKGGPQGGQTRVQLRNEHMTYIITWYALTVLTLWIWVRNYYSVRPHSSVIDFIKREHRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BEY7</accession>
    <name>A0A3S1BEY7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_012974</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000462">
        <property type="protein sequence ID" value="RUS79244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BEY7"/>
    <dbReference type="STRING" id="188477.A0A3S1BEY7"/>
    <dbReference type="OrthoDB" id="8727472at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS79244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="169" mass="19170" checksum="C00A5C6EA32222F1" modified="2019-04-10" version="1">MSNQGFMMDSRRMAKKSKFTLSMFYFDLLWYLYSEKRKERTIRCASTIRCVSTIRPVSTIRCVSTIRPVSTIRCVLTIRCVSTIRCVSTIRCVSTIRPVSTIRCVSTIRPVSTIRPVSTIRCVSTIRCVSTIRCVSTIRCVSTIRPVSTIRPVSTIRPVSTIRFVVGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BG47</accession>
    <name>A0A3S1BG47_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="1">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_009059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="1"/>
    <dbReference type="EMBL" id="RQTK01000255">
        <property type="protein sequence ID" value="RUS83159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BG47"/>
    <dbReference type="STRING" id="188477.A0A3S1BG47"/>
    <dbReference type="OrthoDB" id="26387at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044046">
        <property type="entry name" value="E3_ligase_UBR-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF24">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18995">
        <property type="entry name" value="PRT6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="E3 ubiquitin-protein ligase UBR-like C-terminal" evidence="2">
        <location>
            <begin position="36"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS83159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="226" mass="25014" checksum="311CDF056C8A6EFD" modified="2019-04-10" version="1" fragment="single">DSEELESTSEGYELLEVYKALREHAHVVDSALPCSTTLLLHVKNACLPFLRCACILYHHVTGVMYPPELACKNSNELSHMLKYLALPAHLPDLFTKQGPTTTALIKSWCSNANVRERLTASSEALVHHPLRLNQLIDLPQDYSLLLNEASTFKCPKSDGDDRAPSATDQTPAYETTQSYCCLAELEGTQVGAATEHAYYCGAHSGIFLRVRECQVLLLSNKSRGCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BGC5</accession>
    <name>A0A3S1BGC5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_009238</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000262">
        <property type="protein sequence ID" value="RUS83001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BGC5"/>
    <dbReference type="STRING" id="188477.A0A3S1BGC5"/>
    <dbReference type="OrthoDB" id="6146288at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001562">
        <property type="entry name" value="Znf_Btk_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00779">
        <property type="entry name" value="BTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51113">
        <property type="entry name" value="ZF_BTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS83001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="233" mass="26432" checksum="2B05B81B572986D7" modified="2019-04-10" version="1" fragment="single">MSTASLSSAHAVRLSTQLVDTMLKRAQGRSAFFTSINYKERTFVLDANSLRYYDGDLRVVYFDEFELLRLYVVANSPERQQAWIKAIKREAVKHGAEFLPSYHPGLYIKSNGRWDCCDDINKLSEGCRRIVALPEMKLCGADLNVSNTASMRAKSPVPVKVAMMLKKSQNKSTFFSSNKYQERVFTLDSYALAFYSGYLEDDGKLKGSIPFVEMLVVEPVKDGMLDDKINVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BKJ5</accession>
    <name>A0A3S1BKJ5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_006337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000156">
        <property type="protein sequence ID" value="RUS85934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BKJ5"/>
    <dbReference type="OrthoDB" id="10447422at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018533046" evidence="1">
        <location>
            <begin position="22"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS85934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="282" mass="29537" checksum="F60BA0AE9468972E" modified="2019-04-10" version="1">MAASTVLKMAVVALTVCVIAGTPVNTRVEKRLLKDVFDPVKDYASNAISDVQDWLSDDGEAPVFLKNTVDTITDLTGKAINGIQSWFSNDDSQAKNSELGEEMITRGKHLLQLAANLSQKAYEDAADPATRQKIKAALASVTEAATDVVNAGKTVIQNKGKITAAMRQSLQDLSAVAKNSLGPLSRSLNTTKNSVTSAGAALVVAGISAKDSAVALAAALNEMIETSDLISKANRELETVGKNLMSVGKGLFNAGRNIGKSIYNGAQNVAQASGLWTPSESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BKK3</accession>
    <name>A0A3S1BKK3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_006280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000155">
        <property type="protein sequence ID" value="RUS85951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BKK3"/>
    <dbReference type="STRING" id="188477.A0A3S1BKK3"/>
    <dbReference type="OrthoDB" id="6021714at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043:SF36">
        <property type="entry name" value="PROTEIN SINGLE-MINDED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="21"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS85951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="208" mass="23157" checksum="CE7623C9A56E5A82" modified="2019-04-10" version="1">MLEQGLGDAWGQRQPPKTALEKELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGGSIYEYIHPADHDEMTALLNVHHPYHTHILQDVEIERSFFLRMKCVLAKRNAGLTSGGYKKGETKLMYWEWGNVQVPPDTLDIYCQKRSLKCASYCPPLTKVWAGFWSCPDQAASSNTCGMRDLAADPVIYCHSGLVQATPML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BLJ9</accession>
    <name>A0A3S1BLJ9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PPPDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_008609</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000236">
        <property type="protein sequence ID" value="RUS83641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BLJ9"/>
    <dbReference type="STRING" id="188477.A0A3S1BLJ9"/>
    <dbReference type="OrthoDB" id="412286at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101005">
        <property type="term" value="F:deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF80">
        <property type="entry name" value="IP06716P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="4">
        <location>
            <begin position="4"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS83641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="172" mass="19596" checksum="4E810B60C50C2EE7" modified="2019-04-10" version="1" fragment="single">MAREPIFLNVYDMYWINEYTASLGIGVFHSGVEVYGTEYAYGGHPLPLSGVFEIEPRDAEDLGEQFKFKETICLGHTDFTSDDVKKLTEELGKEFRGDQYHLLNKNCNHFTQSLVQILCGKELPSWINRLAYVSSCIPFIEKAIPKEWLTPNALQNVIETNSPDTDSKDQHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BNJ9</accession>
    <name>A0A3S1BNJ9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sigma intracellular receptor 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Transmembrane protein 97</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_021050</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM97/sigma-2 receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001259">
        <property type="protein sequence ID" value="RUS71180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BNJ9"/>
    <dbReference type="STRING" id="188477.A0A3S1BNJ9"/>
    <dbReference type="OrthoDB" id="433124at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051987">
        <property type="entry name" value="Sigma-2_receptor-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016964">
        <property type="entry name" value="Sigma2_recept"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204:SF1">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031032">
        <property type="entry name" value="TMP_97_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="11">
        <location>
            <begin position="8"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR031032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS71180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="178" mass="21072" checksum="A5B4251C429D46EE" modified="2019-04-10" version="1">MGMWRRFLDILFFFYFFTHIPIAIFFDAQSVFPTHFFPRQLVSVREWYCNTYRDAMMADPPSWFQSLVVCEMFVQLPFFFVASYGFFKGAKNCKWLRWPCVVYGTHVATTLIPIIAHVMLHDFSSGRVPGPRTLRERFTLISFYSPYLIIPVLLVVDSLFSKAYKHKYEKKAQAKKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BP16</accession>
    <name>A0A3S1BP16_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Deoxynucleoside kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_004159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000093">
        <property type="protein sequence ID" value="RUS88106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BP16"/>
    <dbReference type="STRING" id="188477.A0A3S1BP16"/>
    <dbReference type="OrthoDB" id="567086at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019136">
        <property type="term" value="F:deoxynucleoside kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050566">
        <property type="entry name" value="Deoxyribonucleoside_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031314">
        <property type="entry name" value="DNK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10513">
        <property type="entry name" value="DEOXYNUCLEOSIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10513:SF24">
        <property type="entry name" value="THYMIDINE KINASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01712">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Deoxynucleoside kinase" evidence="1">
        <location>
            <begin position="85"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS88106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="181" mass="20958" checksum="A22F3E85BD77E701" modified="2019-04-10" version="1" fragment="single">MVDRRFVFPSIVSALLQCSNSSNICRTAVRDNLKYFLRLKSTFVQMNGSYQQSDKHDRPVCSRSQARANLTSRSHSATPARKTVVCIEGNIGCGKTTLLNYFERFQNCEVVAEPVEKWRNVEGYNALGLMYTDPERWGMALQTYIQLTMLQIHNQQQEKDVRLMERSIYSAKYCFTDNLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BPI8</accession>
    <name>A0A3S1BPI8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_006557</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000162">
        <property type="protein sequence ID" value="RUS85681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BPI8"/>
    <dbReference type="STRING" id="188477.A0A3S1BPI8"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120020">
        <property type="term" value="F:cholesterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033344">
        <property type="term" value="P:cholesterol efflux"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042632">
        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001473">
        <property type="entry name" value="ATP-binding cassette transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF71">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="499"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="523"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="556"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="640"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="34"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS85681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="672" mass="74934" checksum="20934469A2F022FE" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BQ74</accession>
    <name>A0A3S1BQ74_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EGW08_020078</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">EC2010</strain>
            <tissue evidence="17">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001103">
        <property type="protein sequence ID" value="RUS72162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BQ74"/>
    <dbReference type="STRING" id="188477.A0A3S1BQ74"/>
    <dbReference type="OrthoDB" id="5876800at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15554">
        <property type="entry name" value="PHD_PHF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000193">
        <property type="entry name" value="lysine-specific demethylase PHF2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041070">
        <property type="entry name" value="JHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050690">
        <property type="entry name" value="JHDM1_Histone_Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23123">
        <property type="entry name" value="PHD/F-BOX CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17811">
        <property type="entry name" value="JHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="15">
        <location>
            <begin position="7"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="16">
        <location>
            <begin position="202"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="458"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="517"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="877"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="979"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="534"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="584"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="603"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="646"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="742"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="764"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="791"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="904"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="935"/>
            <end position="962"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RUS72162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1072" mass="120523" checksum="4E95995E6B2D6733" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BRR9</accession>
    <name>A0A3S1BRR9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_018867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000944">
        <property type="protein sequence ID" value="RUS73365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BRR9"/>
    <dbReference type="STRING" id="188477.A0A3S1BRR9"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS73365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="354" mass="39033" checksum="DA392E95E425EB6C" modified="2019-04-10" version="1">MKKSTQRVGKKSSVSSTPKGRPNSCSTRTSSASKKRGSKVKTGDADTRPKSGKKQSRRKSKQPQASTESELSGDAKNPNTALISGIGWQLSTACVDSSDVYVTKDPKFNDTDSDPDNNSSANDYNDNANDDDDDDDDDGDDDDDISEYAVSEKWQHDDKLGYDKKTSLALDSARDITSIDTERRQNLLEVDQKLREAFKEKVTEHSPRFLEMKWRQETQTELRLPLAEDDGFPPMNLDVTQNLKPDADGKRNKRSKDPFQMQSQYLSPEYTVIREEVKEHNSQKVGDFQQEIFQGKLTPIPEGPSVLARTENAISEFDKTMKGLGTLLEQPGSLAGTGGTAPMSVTYGASSGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BS51</accession>
    <name>A0A3S1BS51_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Calcitonin peptide-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_018600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000914">
        <property type="protein sequence ID" value="RUS73645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BS51"/>
    <dbReference type="OrthoDB" id="6159635at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018717534" description="Calcitonin peptide-like domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS73645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="25891" checksum="E6B88F8DD17D5134" modified="2019-04-10" version="1">MKLLCCISLCLATVSSYSLQTGDAVSGADPSSSQESTGSGPNLLGSASLAALLRYGGNVQDVGVERVPGEGGDSCAGCSRYNPQAMGNGLWERAPSSSRQLPSLAQMMMMTTMPQKTCAGTASALLGLFRDSLSKRGFSDKDVGILVEDILQRLSSEMVSSGPRHESETVVRGYSKYPRYPAQVAEPSYSKRGGYIGRGPYQMRYAPRFGTKLVPNMKNGDGGSKLLRYGRSVKTDGASGTSGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BTB6</accession>
    <name>A0A3S1BTB6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">EGW08_003987</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">EC2010</strain>
            <tissue evidence="18">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 20">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 20">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="RQTK01000089">
        <property type="protein sequence ID" value="RUS88221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BTB6"/>
    <dbReference type="STRING" id="188477.A0A3S1BTB6"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000156">
        <property type="entry name" value="Serine/threonine-protein kinase SIK3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057380">
        <property type="entry name" value="UBA_SIK1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF42">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SIK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23312">
        <property type="entry name" value="UBA_SIK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="22"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="342"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RUS88221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="409" mass="46130" checksum="47F620CF4D7699AE" modified="2019-04-10" version="1" fragment="single">MATNRAGGKDKAGIGPVRVGYYEMERTIGKGNFAVVKLATHMATKTKVAIKIVDKTQLDEDNLKKIYREIEIIQLLRHPHIIRLYQVSRFASTYHLLAHGRMNEKEARRKFRQIVSAVSYCHRRGIVHRDLKAENLLLDANLNIKIADFGFSNFFTPNLPLKTWCGSPPYAAPELFEGVEYDAPKVDVWSLGVVLYVLVCGALPFDGSSLQSLRNRVLAGKYRVPFYMTRDCENLISNMLVVDSEKRYSIAQIVQHPWMRPGSEDNVFVRYTTKKPKINVFLFYQFLCVILLKNLKLMYFCFPSPPLQSVASQSFDHHSAIYHLLADKFRKHPRAMGVCRAPNPASAATGLSPSSPSPSPSPSSVAPIPTPLPVVTRTERRSSITTGIGQYNFNSISISMFIQSIYIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BTG5</accession>
    <name>A0A3S1BTG5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">EGW08_003944</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">EC2010</strain>
            <tissue evidence="22">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="EMBL" id="RQTK01000087">
        <property type="protein sequence ID" value="RUS88306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S1BTG5"/>
    <dbReference type="OrthoDB" id="6077854at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000384">
        <property type="entry name" value="Receptor protein-tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF600">
        <property type="entry name" value="PDGF- AND VEGF-RECEPTOR RELATED, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="540"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="21">
        <location>
            <begin position="135"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="21">
        <location>
            <begin position="437"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="610"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="282"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="724"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="960"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1106"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1390"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="304"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="1111"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1122"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1248"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1264"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1313"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1356"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1393"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="644"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="22">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="RUS88306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1428" mass="155665" checksum="05EF168FC641D301" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C091</accession>
    <name>A0A3S1C091_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_012831</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000452">
        <property type="protein sequence ID" value="RUS79418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C091"/>
    <dbReference type="OrthoDB" id="6435220at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS79418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="122" mass="14525" checksum="05342CA65990DE08" modified="2019-04-10" version="1" fragment="single">FRQRVEFLGENRNCVSVGSFLREFRQRVEFLGENRNCDSVGSFLKEFRQRVEFLGENRNCDSVGSFLREFRQRVEFLEENRNCDSVGSFLREFRQRVEFLEENRNCASVGSFLESLGKEWNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C844</accession>
    <name>A0A3S1C844_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_006618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000164">
        <property type="protein sequence ID" value="RUS85606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C844"/>
    <dbReference type="OrthoDB" id="6162594at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS85606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="639" mass="74091" checksum="AB7477F4E5D0B20E" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H637</accession>
    <name>A0A3S1H637_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha-macroglobulin receptor-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_019249</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000989">
        <property type="protein sequence ID" value="RUS72984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H637"/>
    <dbReference type="STRING" id="188477.A0A3S1H637"/>
    <dbReference type="OrthoDB" id="6359008at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.690">
        <property type="entry name" value="Alpha-macroglobulin, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009048">
        <property type="entry name" value="A-macroglobulin_rcpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036595">
        <property type="entry name" value="A-macroglobulin_rcpt-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF146">
        <property type="entry name" value="CD109 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07677">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01361">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49410">
        <property type="entry name" value="Alpha-macroglobulin receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018608452" description="Alpha-macroglobulin receptor-binding domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-macroglobulin receptor-binding" evidence="2">
        <location>
            <begin position="384"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS72984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="467" mass="53897" checksum="B6192BAF3C7CC0B1" modified="2019-04-10" version="1" fragment="single">MFNRVIKIFFLICRLTAFVAKIIHEANFGEWERDLFIPRDLINKMVVYICSRQNSTTGAFEPLPGDITYDRKMTSINSLLNDKLRADPVPLTAYILIALYEASDVSGDAAFAVAPAKRKAADFLYNRIDNVTEPFQYAIMTYALSLSPKPAPFDKLWKMRRNESDGIYFADKRVYSNPSDFLNTVRYLKPRQELMNDAYSVQATAYALMAHIQSNQGLKYQREMMMAWLNEMRNSIGGFASTQDTILAMESMLKFTQKDPHRNEFKIETMMKSTASPNWQAIFTLLKEDYIRLSTASLPPNKVFGFVSPNSQGTGRALLQLTTTVNVEFQWLLKTPQKDIEGDGEVIKFFDLIVDNLWFGGRNDSIMEMTSCVSWVYQTKSLTSGLAVLEVDIPTGYVVMNDTLRDYVRSRMVPNLKRAEFYERKVVFYFDYLDGSKTCVFFRADRWHPVANATIQHRMRVYDYYEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HIC7</accession>
    <name>A0A3S1HIC7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutaredoxin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_012192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000414">
        <property type="protein sequence ID" value="RUS80022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HIC7"/>
    <dbReference type="STRING" id="188477.A0A3S1HIC7"/>
    <dbReference type="OrthoDB" id="429967at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008554">
        <property type="entry name" value="Glutaredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052565">
        <property type="entry name" value="Glutaredoxin-like_YDR286C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33558">
        <property type="entry name" value="GLUTAREDOXIN-LIKE PROTEIN C5ORF63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33558:SF1">
        <property type="entry name" value="GLUTAREDOXIN-LIKE PROTEIN C5ORF63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05768">
        <property type="entry name" value="Glrx-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS80022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="118" mass="14156" checksum="CA797C49ECB38F51" modified="2019-04-10" version="1">MLQVRLFTNKRCLQQLWQYYMYAALRTNSSFPTQLPLLMLFTKDPCPLCDEALKKLEPFLNQVTLEKVDITASGNELLWEKYRYDIPVFHFNGKYLMKHRADVDLFTKTLEDYFKMQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HLC4</accession>
    <name>A0A3S1HLC4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Adipose-secreted signaling protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_010367</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ADISSP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000317">
        <property type="protein sequence ID" value="RUS81844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HLC4"/>
    <dbReference type="STRING" id="188477.A0A3S1HLC4"/>
    <dbReference type="OrthoDB" id="6246153at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026794">
        <property type="entry name" value="ADISSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13287">
        <property type="entry name" value="ADIPOSE-SECRETED SIGNALING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13287:SF2">
        <property type="entry name" value="ADIPOSE-SECRETED SIGNALING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15006">
        <property type="entry name" value="DUF4517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS81844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="184" mass="20656" checksum="618FBB157CC54288" modified="2019-04-10" version="1">MASSEETNMEEEIQTGDSPKKALHHHHEHNHHAHFLVQDPVEDDLSAHDSQILIEPKGEGYINVRLGFLQVKHVYEVQFSIEDDLGEEVQFDLLQNINVKIDSVKPSENGKGHDITLTFSAAKEKIMKEAITIMSKGPTPRSLTLTLHARVLGKGKGTPSLKKGIHCVRIEWDEESEGSDWQGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HQ96</accession>
    <name>A0A3S1HQ96_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_008200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
            <location evidence="1">Sarcomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the parvin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000220">
        <property type="protein sequence ID" value="RUS84022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HQ96"/>
    <dbReference type="STRING" id="188477.A0A3S1HQ96"/>
    <dbReference type="OrthoDB" id="2099265at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030017">
        <property type="term" value="C:sarcomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030031">
        <property type="term" value="P:cell projection assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071963">
        <property type="term" value="P:establishment or maintenance of cell polarity regulating cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034446">
        <property type="term" value="P:substrate adhesion-dependent cell spreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21304">
        <property type="entry name" value="CH_PARVA_B_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21306">
        <property type="entry name" value="CH_PARVA_B_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000015">
        <property type="entry name" value="Parvin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000011">
        <property type="entry name" value="Parvin, beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028433">
        <property type="entry name" value="Parvin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12114:SF4">
        <property type="entry name" value="GH23568P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12114">
        <property type="entry name" value="PARVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039131">
        <property type="entry name" value="Parvin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="10">
        <location>
            <begin position="85"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="10">
        <location>
            <begin position="254"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS84022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="370" mass="41851" checksum="E69079FC703F3F3E" modified="2019-04-10" version="1">MATSPSPSSTLTPKKKENESFLDKIGTMGRKKKAKEVSELQEEGKHAIESPTSPTVPDIGPEGYQLAENEERSMIEPTSRENPKLIELVQPILVINDELADHRIIVKDIEEDLFDGQILQKLIEKLCNVRVEAMEVTQSEVGQKQKLRVVLDYINHILGVPPLWSQHKWSVDSVHSKNLVAILHLLVALARHFNAPIRLPENVVVTLLVIQKVDNTLVTRTVPEEITGGHDDMDGRGERDAFDTLFDHAPDKLNVVKKSLLTFVNTHLMKLNLEVTDLDNQFHDGVFLIMLMGLLEGYFTPLYQFHATPTTHEHRVHNVKFAFDLMEDAGLARPKARPEDIVHQDLKSTLRVLYHIFIKYKSGPSQGVPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HX26</accession>
    <name>A0A3S1HX26_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_004353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000098">
        <property type="protein sequence ID" value="RUS87875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HX26"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS87875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="165" mass="18095" checksum="2A97311D4F998FA8" modified="2019-04-10" version="1">MNDKREIFNSEKHTTRRVITPFSPITVLPNFPKALEFQATSPTTKKGDNTFLTITVLPNSPKALDLQATSPTTKKGDNTILTITVIPNFPKALEFQATSPTTKKGDNTFLTITVLPNSPKALEFQATSPTTKKGDNTFLTITVLPNFPKALEFQATSPTTRRSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HXZ3</accession>
    <name>A0A3S1HXZ3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_003873</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000085">
        <property type="protein sequence ID" value="RUS88361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HXZ3"/>
    <dbReference type="STRING" id="188477.A0A3S1HXZ3"/>
    <dbReference type="OrthoDB" id="10257697at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF4">
        <property type="entry name" value="NEUFERRICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018555167" description="Cytochrome b5 heme-binding domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="4">
        <location>
            <begin position="52"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS88361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="277" mass="30643" checksum="C18FAD7DEBA67542" modified="2019-04-10" version="1">MKANIALMVSVLACIFAYLYDPKTCRSCVRALLKYVNGGYDQNAGSSNVKVFTREELSKYKGEDGGDVYLALLGSVYDVTKGKRHYGPGGGYSFFSGIDGSAAYVTGEFNEKGLVDDISNLSNQEILGLEEWKSFYEKDYKFVGLVEGSFYDKDGGTLDMMKIFNKKLESAKLEKNLIDNDKEKFPPCNSEWSQNKGGRVWCSTKSGGIARDWAGVPRMYFTAGGSKPRCACVRTRGPPSYDMKSQSHKDRGDLDNPNLNLYPNCHADSDSCPLPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SJ75</accession>
    <name>A0A433SJ75_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_023141</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001835">
        <property type="protein sequence ID" value="RUS69099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SJ75"/>
    <dbReference type="STRING" id="188477.A0A433SJ75"/>
    <dbReference type="OrthoDB" id="6273764at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000007">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4020.10">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003309">
        <property type="entry name" value="SCAN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038269">
        <property type="entry name" value="SCAN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02023">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47353">
        <property type="entry name" value="Retrovirus capsid dimerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50804">
        <property type="entry name" value="SCAN_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SCAN box" evidence="12">
        <location>
            <begin position="185"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="11">
        <location>
            <begin position="321"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="343"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="528"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="22"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="528"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS69099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="924" mass="105406" checksum="8CBC10B590EB975F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SNL5</accession>
    <name>A0A433SNL5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4097 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_021394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001322">
        <property type="protein sequence ID" value="RUS70847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SNL5"/>
    <dbReference type="STRING" id="188477.A0A433SNL5"/>
    <dbReference type="OrthoDB" id="5984441at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="Toastrack_DUF4097"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34094">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34094:SF1">
        <property type="entry name" value="PROTEIN FAM185A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4097" evidence="1">
        <location>
            <begin position="195"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS70847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="379" mass="40865" checksum="8E74DA093B64603E" modified="2019-05-08" version="1" fragment="single">KYLYSFDGQNNARFSSSKTAFPAYPLLPFQSSDTLIEAWCHTVAPRGSLHLNLPFNTVVRPLNPQSYPDMDKAIIELHFDSNHGTEVPNSQNMSQIRDFVKLDVKFDQEIAKMNVAATTIPGVTIPMVCMMWIPLQSDLTASVLSNSNLTVEKLEGNSLDLSAQQGTCYLKNLKCGSLNVQCSAGDIISQSTMLGNIVFHAGACGGILADKLQGSSVVCQTEMGNIHVKSMYTDTAVMGTLAGSIKLGQCHGKMTVQGGRSDVEVGSMEGDVDIGLNQGSVNLYLSRHSNSSIDVEDGNISLSFPDGVQTDLKLDCSHVNLGNNVTLESTNTDVPNQLKGYIGQTGLASVQARTRSGTIAVSQRSWIQSTNLNFQQDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SPI1</accession>
    <name>A0A433SPI1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_021101</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001267">
        <property type="protein sequence ID" value="RUS71135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SPI1"/>
    <dbReference type="OrthoDB" id="6125730at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22823">
        <property type="entry name" value="Gal_Rha_Lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019428812" description="CUB domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="584"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="746"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="816"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="650"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="769"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="837"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS71135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="873" mass="93802" checksum="506A5BC83393BCB7" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SQ19</accession>
    <name>A0A433SQ19_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_020907</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001230">
        <property type="protein sequence ID" value="RUS71342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SQ19"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS71342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="149" mass="16239" checksum="C84D85FC56927975" modified="2019-05-08" version="1">MITQSPCRGKVLAGASHPWRALEICDSAPDLMAVSSVRHAYSTRDLRLCLRLSGYLHPPRRALEIWVSALGLVAVSSVAGGLCCRRPGGEGGGLQNKVCPVQPGGCPFIEHFVLFLPGRFPCDKCLVFLLRCCCLWVGEDLFIYVPQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SQP5</accession>
    <name>A0A433SQP5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_020683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001197">
        <property type="protein sequence ID" value="RUS71555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SQP5"/>
    <dbReference type="OrthoDB" id="6931518at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS71555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="174" mass="19320" checksum="1E6D9D054761BB47" modified="2019-05-08" version="1" fragment="single">PIVGREDNPIVGREDNPIVGREDNPIVGREDNPIVGREDNPIVGREDNPIVGREDNPIVGREDNPIVGREDNPIVGREENPINPIVGREENPIVGREENPIVGREENPIVGREENPIVGREENPIVGREENPIVGREENPIVGREENPIVGREENPIVGREENPIVGREENPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SR55</accession>
    <name>A0A433SR55_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_020505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001168">
        <property type="protein sequence ID" value="RUS71740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SR55"/>
    <dbReference type="STRING" id="188477.A0A433SR55"/>
    <dbReference type="OrthoDB" id="6106769at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS71740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="501" mass="56290" checksum="9AE8B3056952D663" modified="2019-05-08" version="1">MYSECRRWPTTGNAERTLLTLWLEKTLMYCVFKSSGQLYNGDGGGDDNDVGGDDNDVGGDDNDVGGDDNDVGGDDNDVDGDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDLPGKIKVHKSTCFPNDEDDEEEEEEDEGDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDLPGFEDDMRYLIEHLKSIYPHHYSGLHKDIDKLEDDTWSWGIARSACSVGELFSFITRLLPCAYQKGCLSVFSNSSEAGLACLAQHCGDVLRHEAIDATCLTCLVISSTSLSDAQNRCWRVWGSDLRLNPTGLLLLSKTELSPDQTLHSLYFPGQDMTLQRGYIQTEVKEIGTVVCTHLTAIFEHFFEYDLPYKSYEEIMQAQINITHQRLQGTSHVLAGDFNTGIEVTSQDPETDLQAEAPHSHQLLRHYGYDVDTYLEQDGRCTYFKNNSLVSGKNQALDDVLLMTNDFNSVTKQRVLDQTDPILSDHYGVRATLCKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SSI8</accession>
    <name>A0A433SSI8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_020050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001100">
        <property type="protein sequence ID" value="RUS72185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SSI8"/>
    <dbReference type="STRING" id="188477.A0A433SSI8"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="3">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS72185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="388" mass="44400" checksum="25DF1F87FC80934E" modified="2019-05-08" version="1" fragment="single">MLREQVRQKKGGRSAVPITAKLKVIDGHLRAVTGPHPCLLQDFLFQYTRTWDANNSVPPKLVMKWARCALTVLVLLVPAYDLQMPSRSQEPEVDDSLRLANILMQRPVEGPSVRTECRLLNATEYQRIVNAINAAKLDTRVRPNVHDAFSFLHAHPEINKGAHQGPAFLPYHRVLVFLYEKMLRIYDRSVSLCYWDTTVEPDVLDWSALWTPELFGNPRGAVTTGFARGWITPLRTLNREESHHTPFSQTSTKASILEVSNILEEKNVIIIIAIHSRFTTQSIQVETAAYDPIFWFHHAFVDCLYERFRTRQKDRGINPMRDWPAEHGDSTHAPFAPMRLGSLRNIDGAQDFFSKEIVRCTPMPVCSSDSECGQYMRCDRARQKCISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433STM9</accession>
    <name>A0A433STM9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TNFR-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_019614</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001042">
        <property type="protein sequence ID" value="RUS72616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433STM9"/>
    <dbReference type="OrthoDB" id="6069114at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS72616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="38993" checksum="955C1C83882EA29D" modified="2019-05-08" version="1" fragment="single">MCHINGTEDTCAQCGQFTNQSQRTSSYTMDECGHWPLDSRNCRDRKTNTLEISSNRTRECLCDVEKGVYYSPPEVTRNAPIEAFCQTIKGPKCAAGQEPHLDGQCRPCKRGFFKSQIGFRLCEPKTNCQKLSLQYRNQSDGPTEDNVCSDPVVVVVTTPRPKVTEPNVKIPPNPEPPDPRAGVTDLIPASPSTTPSGGPDGSVRLGSSRGTDQDRQEGGDDSSQAGPILGAVLFLVIVVVVIAVILFYRKRKGLSFCCGSSKSCSDLEKNLHHNPALMAEPHQRNKIMLGHCSNNSNGGLVTTTTTTNNTADKVTNNNLSSSNGRLPHYSMSAGGDAGHENVPMHRVNFQTEEGRGWGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SVE9</accession>
    <name>A0A433SVE9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_019020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000964">
        <property type="protein sequence ID" value="RUS73219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SVE9"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS73219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="247" mass="25620" checksum="115E84A8F51781AB" modified="2019-05-08" version="1">MRHRASRTREMAASSSTSLHQQQQQQQQQQHQQQQHQQQQAHNSAVSVAKVEEYAVESSVTVKVTPESPSPSPSLSTPVHFSAPTAVKDAPTTFAGQRSPSGGGEPAASPATAGEESGDLQQEEEGFTAQASEMVTPESPSPSPSLSTPVHFSAPTAVKDAPTTFAGQRSPSGGGEPAASPATAGEESGDLQQEEEGFTAQASEMLGEPDSSRVGTGATSTSVDPLPGSWLAARMADLTPDLQVFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SWE9</accession>
    <name>A0A433SWE9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_018635</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000919">
        <property type="protein sequence ID" value="RUS73592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SWE9"/>
    <dbReference type="STRING" id="188477.A0A433SWE9"/>
    <dbReference type="OrthoDB" id="332281at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009316">
        <property type="entry name" value="COG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024603">
        <property type="entry name" value="COG_complex_COG2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024602">
        <property type="entry name" value="COG_su2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12022">
        <property type="entry name" value="COG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06148">
        <property type="entry name" value="COG2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 2 N-terminal" evidence="10">
        <location>
            <begin position="19"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="COG complex component COG2 C-terminal" evidence="11">
        <location>
            <begin position="377"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="467"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="467"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="484"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS73592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="534" mass="60320" checksum="B185B549ABE00A55" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SYH1</accession>
    <name>A0A433SYH1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-binding protein RFX6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Regulatory factor X 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_018016</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000854">
        <property type="protein sequence ID" value="RUS74210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SYH1"/>
    <dbReference type="STRING" id="188477.A0A433SYH1"/>
    <dbReference type="OrthoDB" id="10056949at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000211">
        <property type="entry name" value="Regulatory factor X, 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039779">
        <property type="entry name" value="RFX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057321">
        <property type="entry name" value="RFX1-4/6/8-like_BCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619">
        <property type="entry name" value="RFX TRANSCRIPTION FACTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619:SF32">
        <property type="entry name" value="RFX-TYPE WINGED-HELIX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25340">
        <property type="entry name" value="BCD_RFX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02257">
        <property type="entry name" value="RFX_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="11">
        <location>
            <begin position="145"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="22"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="108"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00072476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00077088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS74210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="592" mass="66390" checksum="80D0B0C407A0CB2B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SZ04</accession>
    <name>A0A433SZ04_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_017692</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000821">
        <property type="protein sequence ID" value="RUS74544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SZ04"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS74544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="124" mass="13645" checksum="6494C7E522666B1A" modified="2019-05-08" version="1" fragment="single">CRRRSLWAAGRTPWLGKSARAAAGRWGRTLGPGSAALSADLRSVSDGWILPQSGTQGGDLLGTSLQVDGSGPRGLVRVVVHLEYNHKDAYLRFIRQECYVDLLQRLDELSTGRLAQLIERFIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T0G4</accession>
    <name>A0A433T0G4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_017196</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000776">
        <property type="protein sequence ID" value="RUS75041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T0G4"/>
    <dbReference type="OrthoDB" id="10555513at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019201287" evidence="3">
        <location>
            <begin position="24"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS75041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="311" mass="33010" checksum="DE811DF5F47C97B6" modified="2019-05-08" version="1">MLARDWIALTVLAAFLILTLRDALLGPRSASGVTSGVTSGVTSGVTSAAGKSSDRSNMADDLMQVIMTLTAIMALAFLCFIAAILVFGLWMLKNALDDEVRRRSPDVHALTARSQELEDRSGGKLGAVSDVTSLEQRYHALSSRLLALTAAPASPANGRLAEEELVSRTNSSVAQAPPPSPPSSPPPPLAPRTTSLGPSPSEYLHALRMLADKAQALLAGMEAADKGRAGRPLSALVVEADDTERDALIAKMKSQEQQVSDVRDSLTELESCRDHVMLQASQESAASIRLQMDTLLAQWSRLSDVHSANMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T0Y4</accession>
    <name>A0A433T0Y4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_017022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000762">
        <property type="protein sequence ID" value="RUS75206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T0Y4"/>
    <dbReference type="OrthoDB" id="6146069at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031110">
        <property type="term" value="P:regulation of microtubule polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000956">
        <property type="entry name" value="Stathmin_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00345">
        <property type="entry name" value="STATHMIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS75206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="113" mass="13271" checksum="C97F3012A32BB983" modified="2019-05-08" version="1" fragment="single">HESNEEKKKEDKAEQERQIAQALEQSRQEQESKFQAFLAEEREKQRKATEKSLEEERLACQERLQEALAAEVDRGRARLEEARIEAAERLSEERQNHEAALAAVREEEKRLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T247</accession>
    <name>A0A433T247_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_016619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000724">
        <property type="protein sequence ID" value="RUS75626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T247"/>
    <dbReference type="STRING" id="188477.A0A433T247"/>
    <dbReference type="OrthoDB" id="769138at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS75626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="28596" checksum="4F306C1BAE1AAF52" modified="2019-05-08" version="1">MCLLRTKIMNLPDAIVTKLQHIMQQERAFYNQLNLKDLSQADFEHYLSVREKCVQYIKVPHIYFGAQADTFATAVAILDVFLWKIKNVPTAREIASLNSWTAKDLCRMELHVLERLGWHVGLVSYLSLLPILADAFGLSRDLVLSDSVVGLATRFLCRKSTVLFTPSTLAVALVQHIIGENVNSPAENQIGVHCNVEETQLVECIKLLSFLSDTDYASPPVSPPRLSPRFPLKIFDKPSMAGVTPLYTITEEPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T3A2</accession>
    <name>A0A433T3A2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_016262</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000695">
        <property type="protein sequence ID" value="RUS75980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T3A2"/>
    <dbReference type="STRING" id="188477.A0A433T3A2"/>
    <dbReference type="OrthoDB" id="10068240at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005272">
        <property type="term" value="F:sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 11" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="9 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS75980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="137" mass="15995" checksum="BA297F84E8497211" modified="2019-05-08" version="1" fragment="single">MQVGVEAIDIWTMAYLDENLQTYYKAMKTDHMLGDKDLEEKAHEIDTWTRDTRDQHDLRRVVNNVDAQFTGALSDMLDEMTSFKETEKIDARFMRENILHLNVYFKELSYTEITQQEAYGLVSLFCDIGGSMCLFMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T3I2</accession>
    <name>A0A433T3I2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_016132</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000687">
        <property type="protein sequence ID" value="RUS76101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T3I2"/>
    <dbReference type="STRING" id="188477.A0A433T3I2"/>
    <dbReference type="OrthoDB" id="10055550at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001607">
        <property type="term" value="F:neuromedin U receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005390">
        <property type="entry name" value="NeuromedU_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01565">
        <property type="entry name" value="NEUROMEDINUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="247"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="44"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS76101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="313" mass="35134" checksum="67329FB56504A588" modified="2019-05-08" version="1" fragment="single">MAANLSATELERYRLIRALLENITVSDRQSDHVVQLFQTELARSNFSLRPDEVSARYMRTVTNYYLFNLSVSDLLLLVIGLPHETYDAWHAYPYTLGLTFCRLRYLASETSGYVSILTITAFTVERYMAICHPIRCPTQRGLSRPIRVILCVWVTSVAAAVPMALQVGIDSHTWRDQVVPGTQVCATTDPVLAGTAFQVSTWLFFVLPMSAISLLYCLIALAIRRSTLNRGASDQSADSTALHRSPLYVWLSPPAPVAVVIAFFACWAPFHAYRLLYVYVQERSALVVTVHNVLFYVSGVTYYVSATINPVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T6N1</accession>
    <name>A0A433T6N1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_015139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000610">
        <property type="protein sequence ID" value="RUS77102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T6N1"/>
    <dbReference type="OrthoDB" id="6094519at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS77102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="233" mass="25976" checksum="B07037A2D05A5A5E" modified="2019-05-08" version="1">MASRGILGAGSIPFIGCVVLLVAIFLHILAFASPAWASDDYGKFGLWRTHDDYCTNPNLRFYNTPCRYWADNWEDADWFKAVQALEMITIIFWVWPLIILPVYIYVAMGLYYKCLMGTMTAFTFLGAATNIAGLIIFGIEIETTSNLSHNWCLPVCAAGGLLGFLAFIIFLVACLNRPKFVHEQHFLSGFYADPDKNRMYVVENVEPPAASVAPSNSVKISPAQVVDSGLYYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T805</accession>
    <name>A0A433T805_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small G protein signaling modulator 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">RUN and TBC1 domain-containing protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_014542</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small G protein signaling modulator family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000559">
        <property type="protein sequence ID" value="RUS77706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T805"/>
    <dbReference type="STRING" id="188477.A0A433T805"/>
    <dbReference type="OrthoDB" id="44736at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17688">
        <property type="entry name" value="RUN_SGSM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11813">
        <property type="entry name" value="SH3_SGSM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000012">
        <property type="entry name" value="Small G protein signaling modulator 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000013">
        <property type="entry name" value="Small G protein signaling modulator 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.900:FF:000016">
        <property type="entry name" value="Small G protein signaling modulator 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000115">
        <property type="entry name" value="Small G protein signaling modulator 3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035833">
        <property type="entry name" value="SGSM3_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF13">
        <property type="entry name" value="RUN AND TBC1 DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="9">
        <location>
            <begin position="168"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="538"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="RUN" evidence="10">
        <location>
            <begin position="613"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS77706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="805" mass="92106" checksum="2058C6E7560F2263" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T972</accession>
    <name>A0A433T972_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tryptophan 2,3-dioxygenase</fullName>
            <shortName evidence="1">TDO</shortName>
            <ecNumber evidence="1">1.13.11.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Tryptamin 2,3-dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Tryptophan oxygenase</fullName>
            <shortName evidence="1">TO</shortName>
            <shortName evidence="1">TRPO</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Tryptophan pyrrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Tryptophanase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_014172</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-tryptophan + O2 = N-formyl-L-kynurenine</text>
            <dbReference type="Rhea" id="RHEA:24536"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
            <dbReference type="EC" id="1.13.11.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
        <text evidence="1">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer. Dimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tryptophan 2,3-dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.11" evidence="1"/>
    <dbReference type="EMBL" id="RQTK01000535">
        <property type="protein sequence ID" value="RUS78060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T972"/>
    <dbReference type="STRING" id="188477.A0A433T972"/>
    <dbReference type="OrthoDB" id="447477at2759"/>
    <dbReference type="UniPathway" id="UPA00333">
        <property type="reaction ID" value="UER00453"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004833">
        <property type="term" value="F:L-tryptophan 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019442">
        <property type="term" value="P:L-tryptophan catabolic process to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01972">
        <property type="entry name" value="T23O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004981">
        <property type="entry name" value="Trp_2_3_dOase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10138">
        <property type="entry name" value="TRYPTOPHAN 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10138:SF0">
        <property type="entry name" value="TRYPTOPHAN 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03301">
        <property type="entry name" value="Trp_dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0823">Tryptophan catabolism</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="383"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS78060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="417" mass="48271" checksum="7AE98441EF939C0B" modified="2019-05-08" version="1">MAECPLGMNGTSSCPVNGQEGEETLNYHSYLKLDKLLNSQVMQSGIKSQAVHDEHLFIITHQAYELWFKQVLHEIDSVREMFMLPMLDESKTLLILNRLQRVTLILKLLVDQIDILETMTPLDFLEFRLQLSTSSGFQSLQFRLLENKLGVLESSRVKYNQQHYAKVFNREDQLKQVKDSVEQDSLFQLVERWLERTPGLNFKSFNFWELYKRSVDRWLQDIILSPAEETNDPKIKEEMMAEYKKQKDSFDSVLDEDKYKSSMARGDRRLSHAAFKGAILISLYHDQPRFNQPSKLLSLLMDIDSLLTKWRYNHVMMVQRMIGSKVGTGGSSGYQYLRSTVSDRYKVFLDLFNTSTFLIPRAYIPPLTRSLKRQLSILCHDHIPGESSEEDNDDDEKVEGDTANGNGAIGAKVKFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TD08</accession>
    <name>A0A433TD08_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_012747</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000448">
        <property type="protein sequence ID" value="RUS79479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TD08"/>
    <dbReference type="STRING" id="188477.A0A433TD08"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005005">
        <property type="term" value="F:transmembrane-ephrin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000143">
        <property type="entry name" value="Ephrin type-B receptor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027936">
        <property type="entry name" value="Eph_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050449">
        <property type="entry name" value="Ephrin_rcpt_TKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46877">
        <property type="entry name" value="EPH RECEPTOR A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46877:SF14">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14575">
        <property type="entry name" value="EphA2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="91"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS79479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="182" mass="20184" checksum="D122E7E63945DA9E" modified="2019-05-08" version="1" fragment="single">MAIATIMIVILLRRNRPNCSEKKDCDAYSHVIQYPPLEHHINGGYGGLTMPLFPSPGSVHSSVRTYVDPHTYEDPNQAVREFTREIDACHITIESVIGGGEFGDVCKGKLRMPGRPEMTVAIKTLKPGATEKNRLDFLTEASIMGQFDDPNVIFLEGVVTKSNPIMIVTEYMANGSLDTFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TFB3</accession>
    <name>A0A433TFB3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CobQ/CobB/MinD/ParA nucleotide binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_011957</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000401">
        <property type="protein sequence ID" value="RUS80273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TFB3"/>
    <dbReference type="STRING" id="188477.A0A433TFB3"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001278">
        <property type="entry name" value="Iron-sulfur cluster carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961:SF2">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS80273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="28909" checksum="F1B793ACA477C1FE" modified="2019-05-08" version="1" fragment="single">KARGLPKRLPIPGVDHVILVSSGKGGVGKSTTAGYLFILKLEGHKVGILDGDIYGPSIPTLMNLHGEPELNKQNLMLPLVNYGIKCMSMGFLVDSQSAIVWRGLMVMSAVQRLIRQVRRRSRDSFVCLNTTDVEIDVNVFNMTISCPGSVIVTTPQDLSLLDARRALTMYQQVGVPCLGLVENMSVFVCPSCGHRESIFGQDGGTDLAGEVGVEVLGRVPLHRSIRELSDSGQPVVVSQPDTPHAQVYREMAEKIIATLAQSKAQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TFK5</accession>
    <name>A0A433TFK5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_011891</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000397">
        <property type="protein sequence ID" value="RUS80352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TFK5"/>
    <dbReference type="STRING" id="188477.A0A433TFK5"/>
    <dbReference type="OrthoDB" id="1616686at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19756">
        <property type="entry name" value="Bbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="15"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS80352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="619" mass="69454" checksum="A6472582B56B4235" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TG68</accession>
    <name>A0A433TG68_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_011700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000385">
        <property type="protein sequence ID" value="RUS80560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TG68"/>
    <dbReference type="STRING" id="188477.A0A433TG68"/>
    <dbReference type="OrthoDB" id="5326588at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050613">
        <property type="term" value="F:Delta14-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF52">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE TM7SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS80560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="244" mass="27988" checksum="1C76581B4AD6F23B" modified="2019-05-08" version="1">MAFFFGNVSRYVFGRVELKFFLYAHVGMIAWGILDLLILLNSMLEGTVTAPLIFIAVSQYIIVAHTMFFENFLHTRPFMESEGLGFFWMLRVLLYLPFLHSLPAYYAAVTEVTLTKPALMANCVFFLFGFVIYVTSIHQKENFVADPASYKNLRSLPYLPGKRVMVSGYWGIVQKPDYLGYMIMWMAWALACGLSGLAVLVLVVIYVSMLLMLQQSISIKKMKYGSAWKRYIAQVPYKLIPHVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TH92</accession>
    <name>A0A433TH92_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tyrosine-protein kinase ephrin type A/B receptor-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_011305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000365">
        <property type="protein sequence ID" value="RUS80924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TH92"/>
    <dbReference type="STRING" id="188477.A0A433TH92"/>
    <dbReference type="OrthoDB" id="439917at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46104:SF1">
        <property type="entry name" value="GENE 9195-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46104">
        <property type="entry name" value="GENE 9195-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein kinase ephrin type A/B receptor-like" evidence="1">
        <location>
            <begin position="306"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS80924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="700" mass="71854" checksum="3AB8ECA0C41FF85D" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433THE4</accession>
    <name>A0A433THE4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Allograft inflammatory factor 1-like EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_011227</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000360">
        <property type="protein sequence ID" value="RUS81022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433THE4"/>
    <dbReference type="STRING" id="188477.A0A433THE4"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097178">
        <property type="term" value="P:ruffle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049025">
        <property type="entry name" value="AIF-1_EF_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042433">
        <property type="entry name" value="AIF1/AIF1L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10356">
        <property type="entry name" value="ALLOGRAFT INFLAMMATORY FACTOR-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10356:SF0">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21008">
        <property type="entry name" value="AIF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Allograft inflammatory factor 1-like EF-hand" evidence="5">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS81022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="82" mass="9112" checksum="5198ACD561FBE824" modified="2019-05-08" version="1" fragment="single">DVMDVKYLMEKLGQAKTHREVVSMIKEVDSLNQGAISYTDFVRMMLGPKSSVLKIILIFEGLGKPKEKPKGPPPKKDLASLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TLI9</accession>
    <name>A0A433TLI9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_009871</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000289">
        <property type="protein sequence ID" value="RUS82356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TLI9"/>
    <dbReference type="STRING" id="188477.A0A433TLI9"/>
    <dbReference type="OrthoDB" id="6513151at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="27"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS82356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="291" mass="34364" checksum="00BD1288B54F500E" modified="2019-05-08" version="1" fragment="single">AQKEGRTVHRSRFNFFKTWGVNPDSYLSIHKTIFVTKYAAYYFGSEKTSGQPKLVKIFRPTLTWSGRRRAGMEKHILSLDSRPAAMPSLHFAFSYQVYLCLVMEPMFNEPLDVKVLYGRCLMPDVVHCFFLDMVCAVGFLHHNGILHRDLNLSSFWIQGNRHLKLTDYNHCIDRDSHERFYTLFGVKTTDYTAPELLNHDPYSRQSDIWALGIIFYRITRGRMLMKDPLQRLGHDRDTYEAFQNQDYFADVNWENAHRQTRRGPPITWRFCVSTEEEILDEKIDKIKFEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TLX7</accession>
    <name>A0A433TLX7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_009656</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000280">
        <property type="protein sequence ID" value="RUS82582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TLX7"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS82582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="310" mass="34540" checksum="51BFB935D93482F5" modified="2019-05-08" version="1">MLARSKKSFGGRYDDHLVDGVTGVVKAIPFCLLLIMYWAINSQLTNTFFAQAERMDIRLGSVNIPAAALNAFNTIGIIVLIPLVDKVVYPFFERVRYPLTFLKRIGPGGPDVHGVRHVRVHAGPPVLPHRNQRDLRQRHGAENKKHPMNKEYIQAPCLSPALEFAYHQAPVAMQGLLTGLFLASPGIGTWGAVGILAVVRRATRHDPWFSIEINESKMENLMFLLAGLMLLNLLVFCVVAHLYSYQDPRQFQLDVAPRGKPQGELRTLGGTYDRLDGDYHTLGARKDVEDSKCLAVLKEGERTPLTSSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TNQ8</accession>
    <name>A0A433TNQ8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_009015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000253">
        <property type="protein sequence ID" value="RUS83204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TNQ8"/>
    <dbReference type="STRING" id="188477.A0A433TNQ8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS83204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="228" mass="24940" checksum="DDBB7107E5EC7DCC" modified="2019-05-08" version="1" fragment="single">RVSTIVAQQDQVNTNRVSTIGAQQDQVNTNRVSTIVAQQDQVNTNRVSTIVAQQDQVNTNRVSTIVAQQDQVNTNRVSTIVAQQDQVNTNRVSTIVAQQDQVNTNRVSTIVAQQDQVNTNRVSTIVAQQDQVNTNRASTIVAQQDQVNTNRASTIVAQQDQVNTNRASTIVAQQDQVNTNRASTIVAQQDQVNTNRVSTIVAQQDQVNTNRVSTIVAQQDQVNTPGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TPA0</accession>
    <name>A0A433TPA0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E3 ubiquitin-protein ligase Msl2 zinc RING finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_008805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000243">
        <property type="protein sequence ID" value="RUS83433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TPA0"/>
    <dbReference type="STRING" id="188477.A0A433TPA0"/>
    <dbReference type="OrthoDB" id="10012174at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072487">
        <property type="term" value="C:MSL complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037922">
        <property type="entry name" value="MSL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032043">
        <property type="entry name" value="Msl2_Znf-RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16048:SF3">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MSL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16048">
        <property type="entry name" value="MSL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16685">
        <property type="entry name" value="zf-RING_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E3 ubiquitin-protein ligase Msl2 zinc RING finger" evidence="1">
        <location>
            <begin position="39"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS83433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="145" mass="16436" checksum="7A6AE2E44065F47B" modified="2019-05-08" version="1" fragment="single">MDAYNFYICTVRYVMSADPEDKSSWGEIFKYLPSLRQMVSCCVCGNIAFRPQGPDHNVCLHFVCEGCKGGKMRLKPSCSWCKDHDSFVENKRASLLINCFKRLCLYISSSNLGREISNSSMNGHGSEADRILKIIEEVGNFEDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TPQ7</accession>
    <name>A0A433TPQ7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_008727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000240">
        <property type="protein sequence ID" value="RUS83548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TPQ7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS83548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="118" mass="13513" checksum="CB3CAB5F866B2EF2" modified="2019-05-08" version="1" fragment="single">LTTIMLMDLTTIMLMDLTTIMLMDLTTIMLMDLTTIMLMDLTTIMLMDLTTIMLMDLTTIMLMDLTTIMLMDLTTIMLMDLTTIMLMDLTTIMLLDLTTIMLMDLTTVMLMDLSTIML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TPW3</accession>
    <name>A0A433TPW3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_008666</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000239">
        <property type="protein sequence ID" value="RUS83560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A433TPW3"/>
    <dbReference type="OrthoDB" id="10070006at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045912">
        <property type="entry name" value="FOXJ2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46078:SF2">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46078">
        <property type="entry name" value="FORKHEAD BOX PROTEIN J2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="7">
        <location>
            <begin position="432"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="5">
        <location>
            <begin position="432"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="567"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="660"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="713"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="788"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1019"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1218"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1386"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1439"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="574"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="686"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="724"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1085"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1448"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1462"/>
            <end position="1471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS83560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1552" mass="171420" checksum="1571D96BF3B39A94" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TSC9</accession>
    <name>A0A433TSC9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">EGW08_007724</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">EC2010</strain>
            <tissue evidence="20">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="RQTK01000203">
        <property type="protein sequence ID" value="RUS84485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TSC9"/>
    <dbReference type="STRING" id="188477.A0A433TSC9"/>
    <dbReference type="OrthoDB" id="2122982at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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        <property type="term" value="F:ubiquitin protein ligase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:endocytosis"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16724">
        <property type="entry name" value="RING-HC_MIB1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16725">
        <property type="entry name" value="RING-HC_MIB1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02339">
        <property type="entry name" value="ZZ_Mind_bomb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000090">
        <property type="entry name" value="E3 ubiquitin-protein ligase MIB1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="E3 ubiquitin-protein ligase MIB1 isoform X1"/>
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        <property type="entry name" value="E3 ubiquitin-protein ligase mind-bomb"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Putative E3 ubiquitin-protein ligase mib1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt"/>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
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    <dbReference type="InterPro" id="IPR042056">
        <property type="entry name" value="MIB1/2_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010606">
        <property type="entry name" value="Mib_Herc2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037252">
        <property type="entry name" value="Mib_Herc2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040847">
        <property type="entry name" value="SH3_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24202:SF53">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24202">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MIB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06701">
        <property type="entry name" value="MIB_HERC2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18346">
        <property type="entry name" value="SH3_15"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159034">
        <property type="entry name" value="Mib/herc2 domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51416">
        <property type="entry name" value="MIB_HERC2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13 15" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MIB/HERC2" evidence="19">
        <location>
            <begin position="37"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="18">
        <location>
            <begin position="111"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="MIB/HERC2" evidence="19">
        <location>
            <begin position="174"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="497"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="530"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="563"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="596"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="665"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="699"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="842"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="889"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RUS84485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="940" mass="102048" checksum="D8644BAE64BB27C1" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TSP5</accession>
    <name>A0A433TSP5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Calpain catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_007622</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000200">
        <property type="protein sequence ID" value="RUS84595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TSP5"/>
    <dbReference type="STRING" id="188477.A0A433TSP5"/>
    <dbReference type="OrthoDB" id="424753at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00214">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000001">
        <property type="entry name" value="Calpain-1 catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.380:FF:000002">
        <property type="entry name" value="calpain-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033883">
        <property type="entry name" value="C2_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022682">
        <property type="entry name" value="Calpain_domain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF433">
        <property type="entry name" value="CALPAIN-A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01067">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="8">
        <location>
            <begin position="86"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="548"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="550"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="588"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="695"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="743"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="786"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="797"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS84595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="885" mass="97653" checksum="7A3CF29619F9E55A" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TU79</accession>
    <name>A0A433TU79_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial ornithine transporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_007127</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000181">
        <property type="protein sequence ID" value="RUS85122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TU79"/>
    <dbReference type="STRING" id="188477.A0A433TU79"/>
    <dbReference type="OrthoDB" id="409586at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000146">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF12">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="23"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="121"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="229"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS85122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="35798" checksum="816C53B010D2084F" modified="2019-05-08" version="1">MEPPITLIEAETGTLQKNRSNVVDAIIDFAGGTMGGITTVYVGQPLDTVKVKMQTFPTMYRGGFHCFMETFKKDGLARGLYAGTVPSLAANISENAVLFLFYGVCQKIVAGALGGKDVQMMNPFENAVSGGMAAFFSSFTLCPTELIKCRLQAMREMATNGQLEGGLERLKMGPWGLTKEILHQEGVRGLFKGLTATFMREMPGYFFFFGGYELSRHLLTPEGKQKDEIGPLRTVVCGGVGGVALWVSIFPADVVKSRVQVQSVFGVKPPTFREMFMKILRQEGVKKLYTGLGPTVVRTFPATGALFLAYETTKKYLGQLHDYAIGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TZN4</accession>
    <name>A0A433TZN4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_005343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000124">
        <property type="protein sequence ID" value="RUS86938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TZN4"/>
    <dbReference type="STRING" id="188477.A0A433TZN4"/>
    <dbReference type="OrthoDB" id="527209at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS86938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="228" mass="25315" checksum="904769CFEB16BE65" modified="2019-05-08" version="1">MERSGPLPDHQGIKGNFPLEGTSGAVAERGTYTHRQPGEAQAWSTQIRPGDEVLLRAHPAGRNKIQDRMVYPNRLGDIAPTFRRCQTDISLIASAVLHHIYGRFHRKLDTLQHRWLDCHHLAMAVHHKVPQGCTSGFTAAAVPSILCLLDFELLWATPLLKETATSATAACAFQFHISVLDALYPLHPSMIASGKVHGRELVEKFYPDGKKFITMFPDGTGNVLYPFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U661</accession>
    <name>A0A433U661_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_002919</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000059">
        <property type="protein sequence ID" value="RUS89312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U661"/>
    <dbReference type="OrthoDB" id="6089555at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="74"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS89312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="327" mass="38120" checksum="95841AB788228F20" modified="2019-05-08" version="1">METTADHQCLEEVFRQDTVTCANLVSKPCEPSKPEGTANIDMQKVDGVWYMKFNAVDDMAVHLRELRALHMRHDDVITCGFPRSGNHWCFELVNMILNQTTEFKADCFATNLLDIPRDLDLVPAPRNLVTHLRPRHFPAQVTKKNTKLIYIIRNPKDVLVSMYHMNSRFSYDTWRFRGSWSEFLKLHLAGDLPIGLWWDHVKNVEKFAKAHPNLPVHIFQYEKVRAQPVEEIRKLCHFLGRSDALAEKIARVTQFDNMKTKLGKITAMENMVFNEKGVVLRKGKIGDWKNCFSREQKERFDRAFEVNTVDSEWAKKVRPYMDLPSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U6B6</accession>
    <name>A0A433U6B6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glyoxylate reductase/hydroxypyruvate reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_002860</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000058">
        <property type="protein sequence ID" value="RUS89340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U6B6"/>
    <dbReference type="STRING" id="188477.A0A433U6B6"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008465">
        <property type="term" value="F:hydroxypyruvate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05301">
        <property type="entry name" value="GDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000026">
        <property type="entry name" value="Glyoxylate/hydroxypyruvate reductase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF277">
        <property type="entry name" value="GLYOXYLATE REDUCTASE_HYDROXYPYRUVATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="4">
        <location>
            <begin position="13"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="5">
        <location>
            <begin position="30"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00073306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS89340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="242" mass="26361" checksum="497721F5363634F8" modified="2019-05-08" version="1">MSVYDHNLCSFGQVANTPGVSTDSVAELTVALLLMTARRLAEGVDAVKAGEWGDWKPNWMCGTELTGAVLGIYGLGRIGFNVGRRLKPFGFSKIYYCDVNQVSYAKDIDAEYTDFEGLVEKCDFICVCCNLTPQTHHMFNSEIFKKMKNNAILINSGRGGVINHDDLVVALKNGEITAAGLDVTEPEPLPKEHPLVRMKNCVILPHMGSNTWDTRNAMAEIAARNCIAAVSDMTPEGNVATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U6N0</accession>
    <name>A0A433U6N0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_002780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000055">
        <property type="protein sequence ID" value="RUS89483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U6N0"/>
    <dbReference type="STRING" id="188477.A0A433U6N0"/>
    <dbReference type="OrthoDB" id="5843723at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016012">
        <property type="term" value="C:sarcoglycan complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027659">
        <property type="entry name" value="Sgcb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21142:SF2">
        <property type="entry name" value="BETA-SARCOGLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21142">
        <property type="entry name" value="SARCOGLYCANS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS89483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="109" mass="11933" checksum="F59FBC2476BB5CB8" modified="2019-05-08" version="1" fragment="single">MNPSNTMSTMDSRMTTNGASGYSDHGHRSAMALGGNLGASTLSMRAKAARKRRINSKHNSNFRAGFVPVDEDRLQRSGIRGRKRYFLYCLIGTLLGVTVLNLAVTGWLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U6N4</accession>
    <name>A0A433U6N4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_002817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000056">
        <property type="protein sequence ID" value="RUS89444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U6N4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS89444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="217" mass="24123" checksum="A7237B5225063A89" modified="2019-05-08" version="1">MLDSGLSDHHIQDYENMLDSGLGDHRTQDPGLCLWILAVLDSPGMQLRFIEDVFQNKRLTVLRAVTQSQCVGTRACLPAAYFEPVPKDGYTLDSPVFPGNHCVTWPIARKLLLEAKFERGMKKEERETEGGDRVRDRQENGLTGEAKSPALEPRTYCVGPNVQPQGYRASTYAYGIVLNIFNRSKSQSSLQSSKTNQGQKCSVTILSHHGININASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U7C4</accession>
    <name>A0A433U7C4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_002444</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000048">
        <property type="protein sequence ID" value="RUS89741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U7C4"/>
    <dbReference type="STRING" id="188477.A0A433U7C4"/>
    <dbReference type="OrthoDB" id="199400at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22968">
        <property type="entry name" value="DD_EFCAB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46788">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46788:SF1">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="553"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="343"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="191"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="384"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1055"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS89741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1055" mass="119938" checksum="57F8D7DCCBCFFB6F" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U869</accession>
    <name>A0A433U869_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_002266</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000043">
        <property type="protein sequence ID" value="RUS89999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U869"/>
    <dbReference type="STRING" id="188477.A0A433U869"/>
    <dbReference type="OrthoDB" id="10004999at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051336">
        <property type="entry name" value="RhoGEF_Guanine_NuclExch_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826:SF211">
        <property type="entry name" value="LD43457P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826">
        <property type="entry name" value="RHO GUANINE EXCHANGE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="12"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS89999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="296" mass="33662" checksum="71C92A7B10AEF9F4" modified="2019-05-08" version="1" fragment="single">MDEASQQYKVIDVAPLLQTRYAILSGGKAKNGAPIMTFPARPGQPDVSDEDYGKVVTYLCGITPLHESESGFVVVIDRRQDGWGLVKSILLKLSAFFPVHIQVVFLLQPKGFFQRAFADFRSKFVKDELEFKVILCDSPKDIEEWIDMGQLTSDVGGDLEFDAHEWTEHRSAVEKFSKNTAQISTNLSSVVKKMEERELPNDMPGTQTLMRMCQAERRELLEDIDSASAHGDTLLKCIRGDCVSTPLTKLCHVLELERLLVQLDESRTGFGEFWVRHENKLQQCLVLREFEEEFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U9G8</accession>
    <name>A0A433U9G8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Lysosome-associated membrane glycoprotein 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Lysosome-associated membrane protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">EGW08_001791</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">EC2010</strain>
            <tissue evidence="24">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Cell projection</location>
            <location evidence="17">Growth cone membrane</location>
            <topology evidence="17">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Cytoplasmic vesicle</location>
            <location evidence="15">Secretory vesicle</location>
            <location evidence="15">Synaptic vesicle membrane</location>
            <topology evidence="15">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Membrane</location>
            <topology evidence="20">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Recycling endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 20">Belongs to the LAMP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000032">
        <property type="protein sequence ID" value="RUS90450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U9G8"/>
    <dbReference type="STRING" id="188477.A0A433U9G8"/>
    <dbReference type="OrthoDB" id="6151129at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072594">
        <property type="term" value="P:establishment of protein localization to organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048528">
        <property type="entry name" value="Lamp2-like_luminal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002000">
        <property type="entry name" value="Lysosome-assoc_membr_glycop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11506">
        <property type="entry name" value="LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11506:SF35">
        <property type="entry name" value="LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01299">
        <property type="entry name" value="Lamp2-like_luminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51407">
        <property type="entry name" value="LAMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="20" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 22" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0770">Synapse</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019439726" description="Lysosome-associated membrane glycoprotein 5" evidence="22">
        <location>
            <begin position="20"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Lysosome-associated membrane glycoprotein 2-like luminal" evidence="23">
        <location>
            <begin position="280"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="238"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="238"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="291"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00053950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00074379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00076257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF01299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="RUS90450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="483" mass="52435" checksum="F720EDD18D69DE6D" modified="2019-05-08" version="1">MHLVVLLVSLATCLTATQGKLFVLNNTDTGSPCILVDVDFTLDLVAIRGEKVIKEAVVSSDDEDIRVGGSCGDISAVLTLFFPGSVNWGLKFEREEDEVFLNKLVQFIPNKIFGKSVPISDYQLMDDPGVLDLGNATYSYECPVAESVDYEAVTVTATDVNFTVTANVSYIHAQAFNVDEGDFIFSVICKGALSTLAPTTSNTSVTMNGTTHITPSTTITQNTTVTQNTTVTQNTTVTPNVTTSFTTPSSPNVTVTSSMKPNTTAPTSPTTTSSPDPPLKLYTVKDGNTTCIAMQAALTLDIKYPVDGEGKTKMAQLFVPQDAESSGNCKLSATAQELVISFFKDWQLKFLFRTTQQSSMLYINEEKQKHPKYTISQIELVGTSDMDKFPGTTWPVGQNFTFKSEKLDFPYISSSKDYYRCHSTLKTRLSSDATIESQNFEVKAFNDNDNEDFSGSAAVCAADSVTPRKRPTLSSAVCSPLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UCG0</accession>
    <name>A0A433UCG0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SOCS box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_000802</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000011">
        <property type="protein sequence ID" value="RUS91478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UCG0"/>
    <dbReference type="STRING" id="188477.A0A433UCG0"/>
    <dbReference type="OrthoDB" id="448455at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24178">
        <property type="entry name" value="MOLTING PROTEIN MLT-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="78"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="111"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="145"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="181"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="214"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="247"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="280"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="314"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="4">
        <location>
            <begin position="469"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS91478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="539" mass="58881" checksum="4218EE88386DC65E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UE12</accession>
    <name>A0A433UE12_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein 198</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_000105</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM198 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000002">
        <property type="protein sequence ID" value="RUS92081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UE12"/>
    <dbReference type="STRING" id="188477.A0A433UE12"/>
    <dbReference type="OrthoDB" id="115781at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025256">
        <property type="entry name" value="TM7S3/TM198-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040236">
        <property type="entry name" value="TMEM198"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31247:SF5">
        <property type="entry name" value="DUF4203 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31247">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 198 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13886">
        <property type="entry name" value="TM7S3_TM198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="TM7S3/TM198-like" evidence="9">
        <location>
            <begin position="71"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS92081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="357" mass="38897" checksum="38EA278A4AF8D935" modified="2019-05-08" version="1">MAGISPTSLVTTGPGSTNVSLPNSTVNGLTTENDLPVDNATVPWSGFDPAETTHSCSITRESYGVVAAIVAVICFLFGVLYTFFGYRFLKAVLFLTGFLFATVLLYMILEEQGDLLPPEGTLACAVGAGILLGLLSMLLPYFGLILTGFSLGAGVAAAVLVLVEQFIHPPTRWIPAGVFLLFGLIFGILGLKFPKGITIIGTSVIGSAVGLASVDYFLELSRASLYLWDRLMADQSDTLCWYSWLMLALWPAVALLGILVQWKCTGSGVDHRIAFRNRHEQGTHVQQSKAQERRETQQTRYRHLYQARRVRGDVISQNYIQSIQHKLSPAMQSLTALNVEANPEEESTATTMLTQVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UEA1</accession>
    <name>A0A433UEA1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_000118</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000002">
        <property type="protein sequence ID" value="RUS92094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UEA1"/>
    <dbReference type="STRING" id="188477.A0A433UEA1"/>
    <dbReference type="OrthoDB" id="203097at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004710">
        <property type="entry name" value="Bilac:Na_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361:SF28">
        <property type="entry name" value="P3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361">
        <property type="entry name" value="SODIUM-BILE ACID COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="648"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="708"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="714"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="749"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="790"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="820"/>
            <end position="844"/>
        </location>
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        <location>
            <begin position="850"/>
            <end position="871"/>
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            <end position="902"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="932"/>
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            <end position="470"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="7">
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            <end position="545"/>
        </location>
    </feature>
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            <end position="468"/>
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        <location>
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            <end position="545"/>
        </location>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS92094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1005" mass="109353" checksum="7E06E727596E9BB4" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z8U0</accession>
    <name>A0A3S0Z8U0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Chitinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_020234</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001130">
        <property type="protein sequence ID" value="RUS72009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z8U0"/>
    <dbReference type="STRING" id="188477.A0A3S0Z8U0"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02872">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000007">
        <property type="entry name" value="Acidic mammalian chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chitinase 3-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018624465" description="Chitinase" evidence="9">
        <location>
            <begin position="18"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="11">
        <location>
            <begin position="18"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="10">
        <location>
            <begin position="553"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="10">
        <location>
            <begin position="786"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="403"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="644"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="418"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="649"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="669"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="725"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="753"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="781"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS72009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="840" mass="91204" checksum="C2B6324212D8E4CE" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZB89</accession>
    <name>A0A3S0ZB89_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_021272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001295">
        <property type="protein sequence ID" value="RUS70962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZB89"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS70962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="163" mass="17545" checksum="707EED07FC0A00C8" modified="2019-04-10" version="1" fragment="single">KEKSPFGGGSKRSTPDSHGSSSGPTFIPINSSYRSAGESPYNTENAAKHFHSKYTGHQTPKCGSANTSGSLDTEDNGEENPSEKSGSGHSPMWKCYIKIEGPDHLLMTFVPSTFEDLLLLNPTPDPDPVPDHSDLLEHDLADPPVTAESLFGTSVEGEIFIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZBT2</accession>
    <name>A0A3S0ZBT2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_020893</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the galactose-3-O-sulfotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001229">
        <property type="protein sequence ID" value="RUS71350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZBT2"/>
    <dbReference type="STRING" id="188477.A0A3S0ZBT2"/>
    <dbReference type="OrthoDB" id="514299at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001733">
        <property type="term" value="F:galactosylceramide sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009729">
        <property type="entry name" value="Gal-3-0_sulfotransfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14647">
        <property type="entry name" value="GALACTOSE-3-O-SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14647:SF87">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06990">
        <property type="entry name" value="Gal-3-0_sulfotr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS71350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="50811" checksum="DCEF6DFE0CD9A9B8" modified="2019-04-10" version="1">MLSMHRPRSILALIATPLLLYVGLQWYMLNNLLLSSSPAHPSRLKPLSAPPAHQESAGDQIHRHEKTCPERRNLVFLKGMKCATNTLIGMLTLFAFKRNLSVALPMDKLIYHNWPYPMTKRDVRPTHRREYNMIFHHAIYTPSVMQALMPPNTVYISIIRQPFSHLQSVFRYFNVAEIAGLSGLEPDNLVEYFSDVERHEEAYKSPRAQRRWCIPDGFSVTRNLQSHCHGMPLGFPAGTQDISGNTVAVDEYIRELSRSFKLVMIVEHLYESVILLRRLMCWEFKDIVFVSNNIAHAPKGGRVKQNDPHIMEFHKRWSHVDYRLYDYFNKTLWKHISTHGSGFYREVKAFKAVQRRVERYCLDVYSRVNENEPLPTHTEASSEWSRKFSISAEDCRILGPNPYKILHKMQNTSNTLDKDLLHEAAKIADVRQHKSLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZE97</accession>
    <name>A0A3S0ZE97_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_015303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000623">
        <property type="protein sequence ID" value="RUS76930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZE97"/>
    <dbReference type="STRING" id="188477.A0A3S0ZE97"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="13"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS76930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="160" mass="18302" checksum="1C5FF4C0CB5327FF" modified="2019-04-10" version="1" fragment="single">MYSFPRDANDSIPLQKVFDLNSDLSYIVPTVLFARALAEASASTPVYLYTFDAEPKLKDPTSPVKGTSHGWDIYFEFEIASSELDRLIFFYADPDPAKFPILSKTFKSFITSFAKTGVPQVNGINTWPRFDMTRERYVAISTTPEERERMFAQRTALWTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZGC7</accession>
    <name>A0A3S0ZGC7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_018020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000854">
        <property type="protein sequence ID" value="RUS74214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZGC7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS74214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="343" mass="37914" checksum="490A5DECAD85D075" modified="2019-04-10" version="1">MKSKRKKKKKDKKAKSDDDDEVENSGHSNKAESEACAPASESTEGGDSSVLPGEVANHEQSSKKKKKKKRKNEGNNSLSVEGGNETEVVDVQSTSCDGVLQITGKCPDQKLERNENKGDDTVNDMMEDSKDCEGTSSKKKKKKRKANKESEDIGEQETKKRKTSSEVEEISAQDGKSNKKKRKDKKEQLHSENTIENSGVDVGEDSNLRYSENGKKKKRKKGQEKVKDVEMENEILVTPNEVECQSKGESHSDGAEKSPSKQNKQRKPRRKKKKNDSTKVKKSIFPGSNLEDLDGYGVIKAPVEQKEKVAKKGGTAARFIDDKLKQNAILLGGGVSKKKSQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZJG2</accession>
    <name>A0A3S0ZJG2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc/iron permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_013086</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000468">
        <property type="protein sequence ID" value="RUS79139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZJG2"/>
    <dbReference type="STRING" id="188477.A0A3S0ZJG2"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF203">
        <property type="entry name" value="FI18611P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS79139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="30893" checksum="425206A766CAE1AB" modified="2019-04-10" version="1">MDVTLCKVITAILLFILTLVFSSIPYFIVARGTRSGRSAQRREWILGHLNCFAGGVFLATLLCHILVEGEEGFEDYKEKARLHTDFPLFNIFVAAGFFIVAFVELVAHKCIGAQNHENTHNHSHVPKAVGLRAFLLLIALSFHTIFDGLAVGLQTSESEVWVVFAAITIHKSVIAFCIGLEIFQGNRDKLVQAAMWLLIFAIMSPIGIGVGIGITSGSSDELARLLAASILQGLAGGTFMYVTFLEILNVHIGHHGQRNVFHVVWALVGFALMAATKLFDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZKF4</accession>
    <name>A0A3S0ZKF4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_011284</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000363">
        <property type="protein sequence ID" value="RUS80964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZKF4"/>
    <dbReference type="STRING" id="188477.A0A3S0ZKF4"/>
    <dbReference type="OrthoDB" id="10059177at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06721">
        <property type="entry name" value="PDZ1_syntenin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06794">
        <property type="entry name" value="PDZ2_syntenin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000043">
        <property type="entry name" value="Syntenin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000065">
        <property type="entry name" value="syntenin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051230">
        <property type="entry name" value="APP-Binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12345:SF3">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12345">
        <property type="entry name" value="SYNTENIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="118"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="202"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS80964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="302" mass="32942" checksum="7AEF6F47D0280593" modified="2019-04-10" version="1">MSLYPTLEDMRVDQLQTAQANHERAITNENPPLQYPHGPGAQPPMYTSNAGAGGLYPSLPEYMGLQITPQMMQSMQVVPSQGMQVGIRQTQSGQNQVAPITGNNIGLARAEIKQGIREVVLCKNQEGKVGLRIRHVNNGLFVAFVQAGLPAAMAGLRFGDQILQINGQTVAGWDNSKAHKFLEKADGGRIEMAVRDRPFERTVTMQKDSNGYIGFVFKEGRIKSLVKDSSAARNGLLTDHQLIEIGGQNCVGLKDKEIGDIIDSCGRTVTVTVMPCVIYDHIVKCMGTSLVKKLMDHSIPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZKW3</accession>
    <name>A0A3S0ZKW3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MACPF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_012095</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000409">
        <property type="protein sequence ID" value="RUS80138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZKW3"/>
    <dbReference type="OrthoDB" id="5950457at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020864">
        <property type="entry name" value="MACPF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039707">
        <property type="entry name" value="MPEG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31463">
        <property type="entry name" value="MACROPHAGE-EXPRESSED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31463:SF1">
        <property type="entry name" value="MACROPHAGE-EXPRESSED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01823">
        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00457">
        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51412">
        <property type="entry name" value="MACPF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="MACPF" evidence="3">
        <location>
            <begin position="27"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS80138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="586" mass="64352" checksum="1C70B72DAF31C614" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZNY6</accession>
    <name>A0A3S0ZNY6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_020378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001149">
        <property type="protein sequence ID" value="RUS71856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZNY6"/>
    <dbReference type="STRING" id="188477.A0A3S0ZNY6"/>
    <dbReference type="OrthoDB" id="10069167at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS71856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="108" mass="12068" checksum="574FA5951AD1A226" modified="2019-04-10" version="1">MSMLFQSSPSPRDPASSSPSPSPLAPPSPPSPAERQSDWSTHFEKLSLVDPGDMTQLKAPQNDVVLTKLISENVRSQKFISMLPEDKQEFASNLRRKQLQRQLPLTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZRV3</accession>
    <name>A0A3S0ZRV3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_011015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000349">
        <property type="protein sequence ID" value="RUS81221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZRV3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS81221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="242" mass="26141" checksum="C261FEA300F077AC" modified="2019-04-10" version="1" fragment="single">MTAQGVVLDQGNIFFRHLVETSPKNKEDDVSSDGGDDDDDFSDNDGGDENRDNRTPICTTGIEKVGVASRFQDHNGYHRRDGEDGEGADQFRESVDACTSHGKTGVPNTGHAPADQAEGRVDEAVSNAAVLDIGQGRTSPSQEASRVVAVSSDQLMNNLKKTLCEFKSDLSPAVTETLTLSDDKDDDGREDSDEADDEDDEDRLPGLARAHLSYSDSQDGEVTHRDEERNAATERDPGGLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZSQ3</accession>
    <name>A0A3S0ZSQ3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_017922</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000843">
        <property type="protein sequence ID" value="RUS74313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZSQ3"/>
    <dbReference type="STRING" id="188477.A0A3S0ZSQ3"/>
    <dbReference type="OrthoDB" id="412240at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07207">
        <property type="entry name" value="Pat_ExoU_VipD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052580">
        <property type="entry name" value="Lipid_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46394">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46394:SF1">
        <property type="entry name" value="PNPLA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2 3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="6">
        <location>
            <begin position="267"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="597"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="78"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="725"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="776"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="864"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="3">
        <location>
            <begin position="271"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="3">
        <location>
            <begin position="300"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="3">
        <location>
            <begin position="443"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="133"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="726"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="737"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="869"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS74313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="929" mass="103859" checksum="C509351FB1D301A3" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZVS2</accession>
    <name>A0A3S0ZVS2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 9">RNA polymerase II subunit A C-terminal domain phosphatase</fullName>
            <ecNumber evidence="2 9">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_008065</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">This promotes the activity of RNA polymerase II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="2 9"/>
    <dbReference type="EMBL" id="RQTK01000215">
        <property type="protein sequence ID" value="RUS84178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZVS2"/>
    <dbReference type="STRING" id="188477.A0A3S0ZVS2"/>
    <dbReference type="OrthoDB" id="10249888at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17729">
        <property type="entry name" value="BRCT_CTDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000040">
        <property type="entry name" value="RNA polymerase II subunit A C-terminal domain phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000007">
        <property type="entry name" value="RNA polymerase II subunit A C-terminal domain phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039189">
        <property type="entry name" value="Fcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011947">
        <property type="entry name" value="FCP1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02250">
        <property type="entry name" value="FCP1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081">
        <property type="entry name" value="RNA POLYMERASE II CTD PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081:SF36">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="12">
        <location>
            <begin position="149"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="11">
        <location>
            <begin position="481"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="303"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="380"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="586"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="630"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="405"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="600"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="630"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="684"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="697"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS84178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="753" mass="84501" checksum="E6528FD8B7D3E97E" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZXZ2</accession>
    <name>A0A3S0ZXZ2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_003493</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000074">
        <property type="protein sequence ID" value="RUS88776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZXZ2"/>
    <dbReference type="STRING" id="188477.A0A3S0ZXZ2"/>
    <dbReference type="OrthoDB" id="6154916at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050971">
        <property type="entry name" value="Cadherin-domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025">
        <property type="entry name" value="DESMOGLEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025:SF23">
        <property type="entry name" value="NEURAL-CADHERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="39"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="179"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="248"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS88776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="274" mass="29365" checksum="C944DC8786B0DE7B" modified="2019-04-10" version="1">MANSGPWTGQWSVTDQQTQADPEVTVRIQDENDNAPVFVSSVFDVTVSESAKAGSSVAWVLVSDSDTGGGLALSLTGPDAGMFRIEQDVSESAKAGSSVAWVLVSDSDTGGGLALSLTGPDVGMFRIEQDGTVRTNQALDYETRRRHLLTVVATDGVHTSRARLDIHVRDENDHSPQFGQAEYSFEVSEGARPGHTIGQVSALDLDSGKNGRVVYGLVSEWGQEYFLLDAVHGTFTLVKELDFEDVSTGGKEGVRKGREGGWEEGRESVREGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A034</accession>
    <name>A0A3S1A034_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Glutathione reductase</fullName>
            <ecNumber evidence="21">1.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">EGW08_001215</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">EC2010</strain>
            <tissue evidence="24">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16 21">Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 21">
            <text>2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="18">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 21">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.7" evidence="21"/>
    <dbReference type="EMBL" id="RQTK01000020">
        <property type="protein sequence ID" value="RUS90998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A034"/>
    <dbReference type="STRING" id="188477.A0A3S1A034"/>
    <dbReference type="OrthoDB" id="5956163at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000003">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000141">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000484">
        <property type="entry name" value="Glutathione reductase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000671">
        <property type="entry name" value="Thioredoxin reductase 2, tandem duplicate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006322">
        <property type="entry name" value="Glutathione_Rdtase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01421">
        <property type="entry name" value="gluta_reduc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004776">
        <property type="entry name" value="PRK06116.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF2">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5 21" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 18 20" id="KW-0274">FAD</keyword>
    <keyword evidence="6 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-0520">NAD</keyword>
    <keyword evidence="8 21" id="KW-0521">NADP</keyword>
    <keyword evidence="18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14 20" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="23">
        <location>
            <begin position="16"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="22">
        <location>
            <begin position="349"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="17">
        <location>
            <position position="449"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="184"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="19">
        <location>
            <begin position="53"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00056905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU365016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="RUS90998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="460" mass="50158" checksum="D92709F12D35FF3F" modified="2019-04-10" version="1">MNNRFLSNMAPVIKKFDYLVLGGGSGGLASARRAAEFGIKAAVVEEARWGGTCVNVGCVPKKVMFNTAMHAEFIHDHKGYGFDVELKGFDWGRIKKTRDAYIKRLNGIYETNLEKSQVEKIVGHATFTQDKCVEVAGQKYAADHIMIATGGRPLIPPIPGAEHGMSSDGFFELEDLPKKVVVVGAGYIAVELAGIFGALGADTSLLIRYDQVLRNFDSMISKAVTENLEPGNVKLMKRTQISKVTKESDGTLTLETNSGVIDNVNCLLWAVGRVPNSDTIGLENIGVSVDAQNNIIVDEYQNTNVPGVYALGDVCGKALLTPVAIAAGRKLAHRLFDGKKDWKLDYSNIPTVVFSHPPVGTIGFTEEEAEKEYGKSQLKIYNANFVPMYYSVLEHKMRCNMKLICLLPDEKVIGLHMVGQGCDEMLQGFGVAIKMGATKAQFDSCVAIHPTSSEELVTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A5K5</accession>
    <name>A0A3S1A5K5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_008966</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000250">
        <property type="protein sequence ID" value="RUS83286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A5K5"/>
    <dbReference type="OrthoDB" id="6435476at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="479"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="521"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="551"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="575"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="609"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="638"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS83286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="674" mass="73811" checksum="07CEC062D021B9E1" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A5S2</accession>
    <name>A0A3S1A5S2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_000896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000013">
        <property type="protein sequence ID" value="RUS91379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A5S2"/>
    <dbReference type="STRING" id="188477.A0A3S1A5S2"/>
    <dbReference type="OrthoDB" id="6203693at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS91379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="423" mass="46486" checksum="E9FF78B04F102448" modified="2019-04-10" version="1">MIYKLKALFSTHGLPDLIRSDNGPQFVSKEFKAFLRELGISLSATTSSPIFPQSNGMAESAVKNAIKLLQQDDPLFALMNYRATPHSSTGVSPAEALMNRKIRTQVPVGKSFLTVKNNEILIYNESKSIENLDADFKWHFLAVTWATDGTVEIVQDFSVSSVTRNGPGVLHPSDMYLNIYLGKSFFGYISQVSIWGAAFSTDELILMFGTPKAVPRTGALLLGWTHYALNPQVIQTKSSTAGRLVPMCDITGTIASPELTGCDKTKFPDKTPPMLTKECNETATITTDYNTHQVSVSSLGYEFKLNEGGITQNPQIYPEHFLTLGAHDVAVMAKDSEGNVGVCRTRTYVTPNHCEASEPEAAHVEACYDDDPHRGVEVKCPAGQSPSVLVPQYLVCGHLRSYNLENMYTRPDRIVCGGLYPEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A644</accession>
    <name>A0A3S1A644_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_000568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000008">
        <property type="protein sequence ID" value="RUS91595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A644"/>
    <dbReference type="OrthoDB" id="6136374at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS91595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="146" mass="17185" checksum="4B58CA1C1E9B8297" modified="2019-04-10" version="1">MEKSEQQEHKKDACSIPPQRNSKLAMLKNKFKMHVTKTKGKDLPDSLKLRGWQMLSNSSQRKNSKVMKTFLREHLFQLVGAFSLIIFSILFTFQAYLAFRSFQMMNQLHSKPQIPEILYRIYFEGNDWAMNLGRVDLRANTSIFIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AB71</accession>
    <name>A0A3S1AB71_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Presequence translocated-associated motor subunit PAM16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_004965</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM16/PAM16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000115">
        <property type="protein sequence ID" value="RUS87285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AB71"/>
    <dbReference type="STRING" id="188477.A0A3S1AB71"/>
    <dbReference type="OrthoDB" id="10262892at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000006">
        <property type="entry name" value="Import inner membrane translocase subunit TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005341">
        <property type="entry name" value="Tim16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388">
        <property type="entry name" value="MITOCHONDRIA ASSOCIATED GRANULOCYTE MACROPHAGE CSF SIGNALING MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03656">
        <property type="entry name" value="Pam16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS87285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="14305" checksum="4433DF3C7B15A4B5" modified="2019-04-10" version="1">MAKYLAQIIVMGTQVVGKAFARAVRQEFAASQQAAQNASKNRHGNRKSAAADTVSGMTLQEAKQVLNVSDINDQEAVLKNYNHLFQVNDKSKGGSIYLQSKVFRAKERIDLELTNQQQPKKDQSRNADP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AQI0</accession>
    <name>A0A3S1AQI0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_023078</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001802">
        <property type="protein sequence ID" value="RUS69163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AQI0"/>
    <dbReference type="OrthoDB" id="6039680at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051663">
        <property type="entry name" value="CLec_Tetranectin-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22799:SF6">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 4 MEMBER M-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22799">
        <property type="entry name" value="TETRANECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0430">Lectin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018730043" description="C-type lectin domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="237"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS69163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="363" mass="39254" checksum="CB1ECDF845A8B1DA" modified="2019-04-10" version="1">MSVQMSLVSTLLLVAAGTTLSLAVKAAGSSGITLDVTYNSKPDAQAGFLVINCSLAQPSLAQLASVASLAVFGSKPYGGKEENQLAVIDMWSNVPTLADELEESGVSVIGEIGPGRSSFLLLSWNSPIKLYRDSYTCVANGIDRDGQPKTSSTVSKIEVVSDGCYHKIQSLESKFDTQSLQLAGSLKTGSEIIQMVQSLDQRVEGIEEKLDAILFNSKVHSTLLAIDRTKFDISDLYNDTFYLASKEEAVFNLKNANSVCQASGGYLLEIDDDGENQFTFSFAKKIGGSDHFALGGNDVEQEGRFVYFNSKKPVPAHVTWMDARPNNAGGKEHCMEIWLSQGGLNDIPCDTKTKFVCEVPLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AU64</accession>
    <name>A0A3S1AU64_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_023836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01003813">
        <property type="protein sequence ID" value="RUS68402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AU64"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS68402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="213" mass="24243" checksum="1A3E9ED4F41EC973" modified="2019-04-10" version="1">MHKGAVSQLLPHLRNLLPLSRFTNALDLDFLNAVSKVLRIHLLLKRSKQPSTSSYGTHLRNFHSAGFINALDLDFSNASLFLLLPTPPRKEQDGEKNFVKLHIHFFCCFPLHHGKSKMARKTFSLGARARQNPQKKRWARVKAAQYQQDYRERQRLKEQLSVSPPTPAFASPPSLLKCSKQLSPSSYPTSGTSFHPPVKAAQYQQDETERGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AV94</accession>
    <name>A0A3S1AV94_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_023002</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001765">
        <property type="protein sequence ID" value="RUS69236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AV94"/>
    <dbReference type="STRING" id="188477.A0A3S1AV94"/>
    <dbReference type="OrthoDB" id="6116100at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18595">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000006">
        <property type="entry name" value="ATP-binding cassette, sub-family C (CFTR/MRP), member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF415">
        <property type="entry name" value="FI20190P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="497"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="276"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS69236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="554" mass="62976" checksum="589DC3F8D88AC69D" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AVL2</accession>
    <name>A0A3S1AVL2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase family 92 protein</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_018862</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="EMBL" id="RQTK01000943">
        <property type="protein sequence ID" value="RUS73384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AVL2"/>
    <dbReference type="OrthoDB" id="2526284at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461:SF69">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS73384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="194" mass="22717" checksum="7D07E94CAE32E0C5" modified="2019-04-10" version="1" fragment="single">MLEFNKILGADRFVFYNYSTGSNVDQVLQKYIKSGDVTVLPWNLPVRVDTWPPSKQPSDVWYFGQLAALNDCLLRNRHRARYIVFSDLDEFIVPLKDSNWTELISRVRKPPPARSPIHLIQRHARKNRDIFIFQCTFFRKEWPRPLPEFETVSSKLKSSVMGYTRRETEILPAGTRSKMIVNPRLVQEVGVHQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AVU7</accession>
    <name>A0A3S1AVU7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_018633</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000918">
        <property type="protein sequence ID" value="RUS73610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S1AVU7"/>
    <dbReference type="OrthoDB" id="6491773at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000020">
        <property type="entry name" value="Dachsous cadherin-related 1b"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF328">
        <property type="entry name" value="CADHERIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="81"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="188"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="320"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="442"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="561"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="666"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="780"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="886"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="1007"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="1112"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="1234"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS73610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1307" mass="144317" checksum="D1EA3A88BB652B54" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AZG6</accession>
    <name>A0A3S1AZG6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_016145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000687">
        <property type="protein sequence ID" value="RUS76114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AZG6"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS76114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="117" mass="13730" checksum="75337F99CA2EF924" modified="2019-04-10" version="1">MKTDFHRGPNSHSYFTPSVIPWYHTTAILHRVSSPGVTPQLFYTQCYRLRQSDHQNLYTRQKSKFGMWAELGLHVAQFNKSQSIFLTFCYHINPAIFSPKDMRTNTSLVSWLVVINY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AZY8</accession>
    <name>A0A3S1AZY8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_020762</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001205">
        <property type="protein sequence ID" value="RUS71476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AZY8"/>
    <dbReference type="STRING" id="188477.A0A3S1AZY8"/>
    <dbReference type="OrthoDB" id="10249149at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000002">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="12">
        <location>
            <begin position="49"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="13">
        <location>
            <begin position="248"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS71476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="452" mass="50152" checksum="85AA3FDF234FF875" modified="2019-04-10" version="1">MRECISIHVGQAGVQMGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVVDEVRTGTYRQLFHPEQLVTGKEDAANNYARGHYTIGKEHVDLVLDRIRKLADQCTGLQGFLIFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITTACFEPANQMVKCDPRHGKYMACCMLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTAVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGVDSAEAEGEADEGEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B022</accession>
    <name>A0A3S1B022_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_023694</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01002381">
        <property type="protein sequence ID" value="RUS68544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B022"/>
    <dbReference type="OrthoDB" id="6160460at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS68544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="329" mass="37521" checksum="37040F3747994F4B" modified="2019-04-10" version="1" fragment="single">LKDDPLVQADSKCRAIVEEIIEHKTRLDRHQSEWRLGACYRATDQLVNVLLTCSSSELYYKLHWDEDWQLMDTPSVNFSGATNLAFFDGNIYIRYQNKTLNAFFPRHNACYKIYGGSPHKVVSAAMFPVGNELYSVYRGDGNAYEVESLNLNAHRQGKWSQVGKLFTRDMEVANVTNIGSRLVVFWKKTGQSYLSVECFDLTRRESFLLPDQLCSSSGLVTFTHGEQAFALQQNGVLWRISAQKEAPYISLKLELWLWNFHRAVSGAILVNQELWVFDTTEEIDGQSDVRAGAEALSLEGVFRRVRFCFVSTQQTNFVHAVVPKSFISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B162</accession>
    <name>A0A3S1B162_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">5'-3' exoribonuclease</fullName>
            <ecNumber evidence="11">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EGW08_014847</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">EC2010</strain>
            <tissue evidence="15">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Possesses 5'-&gt;3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="11"/>
    <dbReference type="EMBL" id="RQTK01000584">
        <property type="protein sequence ID" value="RUS77401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B162"/>
    <dbReference type="STRING" id="188477.A0A3S1B162"/>
    <dbReference type="OrthoDB" id="372487at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1050:FF:000002">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000001">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000003">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017151">
        <property type="entry name" value="Xrn2/3/4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF41">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037239">
        <property type="entry name" value="Exonuclease_Xrn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Xrn1 N-terminal" evidence="13">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="14">
        <location>
            <begin position="323"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="412"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="485"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="788"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="860"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="868"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="911"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="937"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="959"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="981"/>
            <end position="1000"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
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    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RUS77401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1000" mass="113658" checksum="EDB1AE953CE33321" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B2U3</accession>
    <name>A0A3S1B2U3_ELYCH</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
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    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
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            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
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            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
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            <taxon>Plakobranchidae</taxon>
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            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
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                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
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    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS73669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="116" mass="13081" checksum="8CB73CC252C15A5C" modified="2019-04-10" version="1">MVVLSCCKRVVLSCCKRVVLSCCKRVVLSCFKRVVLSCCKGVVLSCCKRVVLSCCKRAVLSCCKTVVLSCCKTRTLQLCSRTRYTQNHFQHFHFDRSAEADSQNLNSTSWLFLALV</sequence>
</entry>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_016605</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
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            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
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                <person name="Li J."/>
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                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
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                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
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    <name>A0A3S1B5Q0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_019581</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Secreted</location>
            <location evidence="1 9">Extracellular space</location>
            <location evidence="1 9">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Wnt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001038">
        <property type="protein sequence ID" value="RUS72659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B5Q0"/>
    <dbReference type="STRING" id="188477.A0A3S1B5Q0"/>
    <dbReference type="OrthoDB" id="5945655at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018161">
        <property type="entry name" value="Wnt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF91">
        <property type="entry name" value="PROTO-ONCOGENE WNT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00246">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 9" id="KW-0879">Wnt signaling pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS72659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="266" mass="29661" checksum="EB99633FC36C0F40" modified="2019-04-10" version="1">MLVVTGVTSLTLNDGTAKKHLGVRAPRGSKWWSLANLGELSSGLRAPVKQLYNNPSLLPLTKRQRRLVTKNPGTVMAVVSGARMAIEECKHQFRNRRWNCPTKFENHRRSIFGKILQKGCRETAFVYSITSAAVAYSVARACAEGGVSSCSCDARVHQRPAGEGWEWSGCSDNARFGHKFSRKFVDILEKGRDFRYMINLHNNEVGRVHVSNSLEKRCKCHGMSGSCSIKTCWMMLPNFRRIGAKLKDKFDGASQVLPALLAFDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BBM3</accession>
    <name>A0A3S1BBM3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutathione transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_007730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">S-crystallins are structural components of squids and octopi eye lens. Contains relatively little if any GST activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000203">
        <property type="protein sequence ID" value="RUS84491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BBM3"/>
    <dbReference type="STRING" id="188477.A0A3S1BBM3"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005212">
        <property type="term" value="F:structural constituent of eye lens"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000030">
        <property type="entry name" value="Glutathione S-transferase S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000035">
        <property type="entry name" value="hematopoietic prostaglandin D synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF150">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0273">Eye lens protein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="4">
        <location>
            <begin position="15"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="5">
        <location>
            <begin position="94"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00049616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS84491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="24790" checksum="E5145E02312B7358" modified="2019-04-10" version="1">MFRCVPAQQPYSIMPSYKLTYFDLRGRAEVSRLIFAYAKQEFEDKRIQFPDWPALKPNTPFGQLPILEVDGQVIGQSTAINNFLAREFGLYGKTNMESCQVDQIGCLLEDYFQLAIKAMFEKDEAKKAQLMKELKEETAPKYLDLLEKLLKKNGSGYFVGKEITLADINVYNVTWAFLNEAPAALDSFPLLKEFHHKVNSIPQIKSYVDARKPSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BEE8</accession>
    <name>A0A3S1BEE8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Papilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_010521</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000323">
        <property type="protein sequence ID" value="RUS81714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BEE8"/>
    <dbReference type="OrthoDB" id="5950222at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048019">
        <property type="term" value="F:receptor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050431">
        <property type="term" value="F:transforming growth factor beta binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd22592">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000020">
        <property type="entry name" value="Collagen, type VI, alpha 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010909">
        <property type="entry name" value="PLAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45938">
        <property type="entry name" value="ACP24A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45938:SF11">
        <property type="entry name" value="WAP, KAZAL, IMMUNOGLOBULIN, KUNITZ AND NTR DOMAIN-CONTAINING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08686">
        <property type="entry name" value="PLAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50900">
        <property type="entry name" value="PLAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="103"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="8">
        <location>
            <begin position="251"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="8">
        <location>
            <begin position="307"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="8">
        <location>
            <begin position="382"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="8">
        <location>
            <begin position="478"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="569"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="651"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="753"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="domain" description="PLAC" evidence="10">
        <location>
            <begin position="846"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS81714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="889" mass="98952" checksum="33031682B7CB1C2E" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BGL1</accession>
    <name>A0A3S1BGL1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PDEase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_009054</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000254">
        <property type="protein sequence ID" value="RUS83197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BGL1"/>
    <dbReference type="STRING" id="188477.A0A3S1BGL1"/>
    <dbReference type="OrthoDB" id="189220at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000032">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="6">
        <location>
            <begin position="64"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS83197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="285" mass="33037" checksum="A4641E042C649A06" modified="2019-04-10" version="1" fragment="single">MRGSPEKPDTGQTSALSDGDRKMIAQVSQPEFRPRLRSRFLSVSQTRRPQRRSASRLSTEGKLLLDDFYSQPAQLLLDDIGLWDFNVFTFDTLSGGRSVFHIAYHLFQTYDLMRSFRLDTVRLLHFLSLVEANYHESNPYHNVVHAADVTQSMHCFLQETEIYNATSDLEKMVALVAALTHDLDHPGVNNAFLMITENHLATLYENISVLENHHYRCALALLHESGLLDNFVENDRDEFFRQLKELILATDITRQPEFLQIFCRCIESGEFQYRTNPQHRLIMLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BH48</accession>
    <name>A0A3S1BH48_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_008705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000240">
        <property type="protein sequence ID" value="RUS83526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BH48"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS83526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="127" mass="14262" checksum="C9F24A1640DB720B" modified="2019-04-10" version="1" fragment="single">MSPWFSGCVTGSSFLLQTKNLDLDLDQPGATRFSKISTFSPVLLLAEPEARLIMTSLLRKCRVVPIQFVLAGAALLIYVIYSQRPEKINLESKWAELRDEELKKYASVREVGLEFVRKAGRVGNSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BIT9</accession>
    <name>A0A3S1BIT9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_010427</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000320">
        <property type="protein sequence ID" value="RUS81790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BIT9"/>
    <dbReference type="OrthoDB" id="6157305at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052560">
        <property type="entry name" value="RdDP_mobile_element"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026960">
        <property type="entry name" value="RVT-Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36688">
        <property type="entry name" value="ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36688:SF2">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13966">
        <property type="entry name" value="zf-RVT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="506"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS81790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="800" mass="91719" checksum="802649F989DE7A5E" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BJ21</accession>
    <name>A0A3S1BJ21_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_023795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01002823">
        <property type="protein sequence ID" value="RUS68443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BJ21"/>
    <dbReference type="OrthoDB" id="6217024at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS68443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="362" mass="38136" checksum="FE79AA5AC0E93449" modified="2019-04-10" version="1" fragment="single">LDLEGYHDDHLPRELPEDVLDGSIGTLEYPAGAMINGKAQSIPQTSFTNGNFQPTRKLPVEGKVSTGLKQNTPTSSGNTTIVVGKPKIPQKPPKLGALEGFIGNSPSVEEDLNTGVNSATNASTAQLEDSKPPLVRLTSFTADSEDAILPFIEKTPVLSPDSIKRHVERSINPASQAPQVPVHALNAFDNSSTSTHDKASNPNPNSVRTKSDSTTQNFFPSSVKTDGKLSNTDTYSARTKREVSPAYNSRVSPSSQKKSLPFDESSGPQSPVPPPLPPRPTLPSLGKTQAPVTLKPTLSGGVNPGMSKSASGAIKPLLALSPKPGVANSNGFRSPGISDTCGSKEFYFGYDSSISTTTTSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BJ92</accession>
    <name>A0A3S1BJ92_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_010098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000301">
        <property type="protein sequence ID" value="RUS82124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BJ92"/>
    <dbReference type="STRING" id="188477.A0A3S1BJ92"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS82124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="268" mass="31046" checksum="C33401D944B33EBE" modified="2019-04-10" version="1">MFIIRITDPLSKAVAPKHKEFSAIGSALANFARSTTACWDPSLSTQSGQSAEICRRREKDFKLKSSFTSQEKDFKLKSSFTSQEKDFKLKSSFTSQEKDFKLKSSFTSQEKDFKLKSSFTSQEKDFKLKSSFTSQEKDFKLKSSFTSQEKDFKLKSSFTSQEKDFKLKSSFTSQEKDFKLKSSFTSQEKDFKLKSSFTSQEKDFKLKSSFTSQEKDFKLKSSFTSQEKDFKLKSSFTSQEKDFKQKSSFTSQEKDFKLKSSFHGLKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BJJ7</accession>
    <name>A0A3S1BJJ7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_007033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000178">
        <property type="protein sequence ID" value="RUS85207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BJJ7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1810">
        <property type="entry name" value="RNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041948">
        <property type="entry name" value="Rnl1/2_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS85207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="171" mass="19254" checksum="DC16B1976BAC2914" modified="2019-04-10" version="1">MVRHPLCFHVKVVMSPLTRPDYKRHAIKLLSAAFTDVRETVKGKKVQVNYCTKARYLSVISKLDVPEREDTEMVISMFINDIEKESGEPLSINKRKGSVKAVRGWLAKDGYIKDVQTYQAGKTTEPTAQLSNELSTDHICGASSEFTKSIEEEDTDFTEVDMPFGDLFGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BKL2</accession>
    <name>A0A3S1BKL2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SANT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_006294</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000155">
        <property type="protein sequence ID" value="RUS85965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BKL2"/>
    <dbReference type="STRING" id="188477.A0A3S1BKL2"/>
    <dbReference type="OrthoDB" id="515799at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:pattern specification process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055315">
        <property type="entry name" value="Cramped-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21677">
        <property type="entry name" value="CRAMPED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21677:SF1">
        <property type="entry name" value="PROTEIN CRAMPED-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="400"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="456"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="839"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="417"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS85965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="867" mass="94040" checksum="04C195B5BEFAA718" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BP78</accession>
    <name>A0A3S1BP78_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Transient receptor ion channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_003979</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000088">
        <property type="protein sequence ID" value="RUS88277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BP78"/>
    <dbReference type="STRING" id="188477.A0A3S1BP78"/>
    <dbReference type="OrthoDB" id="2373987at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070679">
        <property type="term" value="F:inositol 1,4,5 trisphosphate binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015279">
        <property type="term" value="F:store-operated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007338">
        <property type="term" value="P:single fertilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013555">
        <property type="entry name" value="TRP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002153">
        <property type="entry name" value="TRPC_channel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00870">
        <property type="entry name" value="trp"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08344">
        <property type="entry name" value="TRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01097">
        <property type="entry name" value="TRNSRECEPTRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01420">
        <property type="entry name" value="TRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="512"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="623"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="669"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="709"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="116"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Transient receptor ion channel" evidence="13">
        <location>
            <begin position="233"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="35"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="796"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
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            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
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            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1008"/>
            <end position="1020"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS88277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1037" mass="118638" checksum="3414FE2220B1493F" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BQ39</accession>
    <name>A0A3S1BQ39_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_003483</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
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            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000074">
        <property type="protein sequence ID" value="RUS88766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="188477.A0A3S1BQ39"/>
    <dbReference type="OrthoDB" id="16988at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008467">
        <property type="term" value="F:[heparan sulfate]-glucosamine 3-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037359">
        <property type="entry name" value="NST/OST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605:SF65">
        <property type="entry name" value="GH20068P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605">
        <property type="entry name" value="HEPARAN SULFATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="8">
        <location>
            <begin position="182"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="active site" description="For sulfotransferase activity" evidence="3">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="189"/>
            <end position="193"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="416"/>
            <end position="420"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="394"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS88766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="453" mass="51845" checksum="A5507F7C792DD129" modified="2019-04-10" version="1">MPQHPHTSLHSKKKQTYVMVQYSPLTGGSGTQYDTYRGVHQFAPPPPTIVARCPKLSRYKMAGFLSIALLSLILFTFMAARTSSMGVPFFSGDESSLAGQEGLVAAPMCNLRLPEDAASPLGEGMEQTGDFGLDGVSGQSPDSVDSTELESFNPGQNEVHVYPSDRYEADPTQERIKRFPTAIVIGARKGGTRAVLRFVDLHPDVVTSKREPHFFDREYEQGLEWYRHQMPPSLPSQITLEKTPNYLVDWDVPKRVYTFNSSIKLILIVREPISRAVSDYVQLREAFYKQMEYDEERALKNGRLERLPDFEDLAIDPSTGEVDKSYAPVKRSLYSRHLERWLAFFNMSQILILDGDNIRYRPWEEMAKVEKFLGLSHQVKQNCFVFNETKGFFCVKVVDHKKGNGATVQKCLSESKGRVHPHIDPEVRSKLRDFYRPFNKRFFYKVGRTFDWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BR50</accession>
    <name>A0A3S1BR50_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_002820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000056">
        <property type="protein sequence ID" value="RUS89447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BR50"/>
    <dbReference type="OrthoDB" id="6127581at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS89447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="171" mass="18692" checksum="E95C88640DE0BB8D" modified="2019-04-10" version="1">MPSEECTSLLGRVLFRLGQLLLAAGIMMTFLGISTSNWVVRPKVNYATQNIQANSTLVTENFGLFIACRQSEFGRGRGECGSVWKNTNFVTVVMLTSMVIFAGEVKNKAERVSGQEDEKSGWSFIVALIGLIFCVLGLVLVTMLRDLPIQKPGLKGGTWLRVASRSSGQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BRK1</accession>
    <name>A0A3S1BRK1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_019031</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000965">
        <property type="protein sequence ID" value="RUS73209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BRK1"/>
    <dbReference type="STRING" id="188477.A0A3S1BRK1"/>
    <dbReference type="OrthoDB" id="198619at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01886">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000001">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000001">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000514">
        <property type="entry name" value="Ribosome-releasing factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261:SF1">
        <property type="entry name" value="RIBOSOME-RELEASING FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="43"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="433"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="433"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="451"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS73209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="777" mass="86861" checksum="378011A97A9A2514" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BSL1</accession>
    <name>A0A3S1BSL1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosomal protein L7Ae/L30e/S12e/Gadd45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_001937</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000035">
        <property type="protein sequence ID" value="RUS90339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BSL1"/>
    <dbReference type="STRING" id="188477.A0A3S1BSL1"/>
    <dbReference type="OrthoDB" id="5976967at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024824">
        <property type="entry name" value="GADD45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10411:SF8">
        <property type="entry name" value="FI09246P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10411">
        <property type="entry name" value="GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS90339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="20288" checksum="7342079E3A739757" modified="2019-04-10" version="1">MYTERQIECSLLMSSEISLSKLSEDFGEKSDPTVANTQKASLTISEALAITLKQALQERRLTMGVLDCGKLLSCSPNRVMVCVLPEVTNGDISVLIQHTLIRSFCWEHDIRLLMVKDERSLLDLVRGCPEYKDVTEQSVSCMMLEYPIDGNSEADTFVCGYHDTVMYSDMYPKPIIHLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BTE2</accession>
    <name>A0A3S1BTE2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_017838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000834">
        <property type="protein sequence ID" value="RUS74403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BTE2"/>
    <dbReference type="OrthoDB" id="10045556at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS74403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="376" mass="42837" checksum="1FFF95AD58BDEBBE" modified="2019-04-10" version="1">MVQIKPRRIQSAKGRLEGPSSRPTLENHKLSAGPVFIKEDNKSLDKKSSVVNINAAVDIPDKEETDLILRANILFRGQNELNQKHRVRPSSAKSTFGCPVSNVEAAEKDHKPAKEIIKPSVYGLKLGRQVFGNDSHIQEAWASTARNYPFKLREGEESESRQKKNNELETSKLPLTLMPLQRWLRKDTHSDVTGLDSDKCIIFLSRDYTSDELPEVPPPQELSEDLPYTCIVATPRTEPKKKYCHPFFEHETEDLGWKCSHSNGINSNAHGDISFLLNPPYRRNPQEIRLEIAELENLMQGIGSLSSNCSFVKFQAEIRCARALARKLILPNSSDNQEPTDTFGLLKFYKEHDKAMEIIHERRRICLEELQLIEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BUZ7</accession>
    <name>A0A3S1BUZ7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_000082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000001">
        <property type="protein sequence ID" value="RUS92229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BUZ7"/>
    <dbReference type="STRING" id="188477.A0A3S1BUZ7"/>
    <dbReference type="OrthoDB" id="10051175at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018530260" evidence="1">
        <location>
            <begin position="21"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS92229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="250" mass="27140" checksum="8163EBD295D91921" modified="2019-04-10" version="1" fragment="single">MYRDLVLGVLITLQVTQVTSQCYFSIDTSGLYNLTVSTKPWWLSSGPFAFSSGGQWLSTEDGTLAVSNISTLTAGDDVLGNYTETTWRIFHPSSDATMEAAIRSYDTNDSFVMFVQRFPNGLQKSATHPNKTISAFPSFRLDNQSEKGPGKLGYLSWGSYMLGDMDKKAGVLGPNATFNDGLDGSGPLVIFDQKGHALVLSPFNNFMAASVWQDDHAPLLDWGIMGGVDSLPPGFEHKTLAFCSNDGIGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1CBV0</accession>
    <name>A0A3S1CBV0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NFU1 iron-sulfur cluster scaffold homolog, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_003817</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NifU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000083">
        <property type="protein sequence ID" value="RUS88421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1CBV0"/>
    <dbReference type="STRING" id="188477.A0A3S1CBV0"/>
    <dbReference type="OrthoDB" id="565552at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000001">
        <property type="entry name" value="NFU1 iron-sulfur cluster scaffold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.70:FF:000002">
        <property type="entry name" value="NFU1 iron-sulfur cluster scaffold homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.70">
        <property type="entry name" value="Scaffold protein Nfu/NifU, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014824">
        <property type="entry name" value="Nfu/NifU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036498">
        <property type="entry name" value="Nfu/NifU_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178">
        <property type="entry name" value="IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178:SF1">
        <property type="entry name" value="NFU1 IRON-SULFUR CLUSTER SCAFFOLD HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08712">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00932">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110836">
        <property type="entry name" value="Hypothetical protein SAV1430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Scaffold protein Nfu/NifU N-terminal" evidence="9">
        <location>
            <begin position="82"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS88421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="286" mass="32159" checksum="A40AFB2B372C7A7A" modified="2019-04-10" version="1">MAARSVCQQLRSSQIFKQQYTTKLLRETRALCTHNYVGSRDISASSRRCYGMWKRQNVNFQPGKLLQGNFPTSFQMTRTMFIQTQDTPNPNSLKFMPGVEVLESGTYDFPNPQSGHCSPLAKMLFRINGVKGVFFSKDAITITKADDDLEWAVMKPEIFAVIMDFFATGLPVLTDEKPSGDTVINEDDDETVALIKELLDTRIRPTVQEDGGDIVYMGFEKGVVKLKMQGSCSSCPSSIVTLKSGVQNMLQFYIPEVLSVEQVTDEAEAISNEEFRKLEEQLNKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1CG36</accession>
    <name>A0A3S1CG36_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_000547</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000007">
        <property type="protein sequence ID" value="RUS91721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S1CG36"/>
    <dbReference type="OrthoDB" id="433501at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47357">
        <property type="entry name" value="COP1-INTERACTIVE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47357:SF1">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT 110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="823"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="916"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="302"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="425"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="732"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="768"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1010"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1105"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1239"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1391"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2387"/>
            <end position="2447"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="474"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="593"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="872"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1449"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1501"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1576"/>
            <end position="2164"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2214"/>
            <end position="2280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="425"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="441"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="740"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="771"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1105"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1129"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1156"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1253"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1278"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1391"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2409"/>
            <end position="2422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2431"/>
            <end position="2440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS91721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="2447" mass="276863" checksum="7CB961DC01DFF121" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H0Z3</accession>
    <name>A0A3S1H0Z3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_022191</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family. C/EBP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001506">
        <property type="protein sequence ID" value="RUS70042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H0Z3"/>
    <dbReference type="STRING" id="188477.A0A3S1H0Z3"/>
    <dbReference type="OrthoDB" id="10039716at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031106">
        <property type="entry name" value="C/EBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23334">
        <property type="entry name" value="CCAAT/ENHANCER BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23334:SF69">
        <property type="entry name" value="CCAAT_ENHANCER-BINDING PROTEIN GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="34"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="28"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS70042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="149" mass="16963" checksum="EECB07D4AD680E40" modified="2019-04-10" version="1">MPPKKSYESYDSESDDSQGQKRGSGKRQKLDKNSDEYRQRRERNNLAVRKSREASRKKAKETMDKVSKLRDENRALEQKVTILNKELMVLKDLFMTHASATATAQAASPVPASTEASLSTNLLDFTEQKDGKEEVRLERNSLFHLKGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H1E3</accession>
    <name>A0A3S1H1E3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_021945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001446">
        <property type="protein sequence ID" value="RUS70268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H1E3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS70268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="250" mass="29333" checksum="27A0AD0A52E5B753" modified="2019-04-10" version="1">MPKCGWNIDKDIRDNVFEYLSTFEPDVFIIDTSIELFLDNDSKTLDEVKTELSIACKNHVILTETVNTYMFQECDYAHTHSYDMGHRFVFLGYHKERYTKDTVRLMKFLTPIRRLTAVEKILSKSMKENTLQHANKNEQYDNTFSDIINVDYNTNGRVTNMRRALPRARHTAKVSFMKYLLLCCYLDTNNECDDDNINGVNEDELYGDREIEDDAEYAPPVELLRELYKKGIDINEIPQVGTDFERLSMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HD94</accession>
    <name>A0A3S1HD94_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">Polyprenal reductase</fullName>
            <ecNumber evidence="2 9">1.3.1.94</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_015197</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a key role in early steps of protein N-linked glycosylation by being involved in the conversion of polyprenol into dolichol. Acts as a polyprenal reductase that mediates the reduction of polyprenal into dolichal in a NADP-dependent mechanism. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>a di-trans,poly-cis-dolichal + NADP(+) = a di-trans,poly-cis-polyprenal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:80727"/>
            <dbReference type="Rhea" id="RHEA-COMP:19536"/>
            <dbReference type="Rhea" id="RHEA-COMP:19537"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:231623"/>
            <dbReference type="ChEBI" id="CHEBI:231637"/>
            <dbReference type="EC" id="1.3.1.94"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8 9">
            <dbReference type="Rhea" id="RHEA:80729"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 9">Belongs to the steroid 5-alpha reductase family. Polyprenal reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.94" evidence="2 9"/>
    <dbReference type="EMBL" id="RQTK01000615">
        <property type="protein sequence ID" value="RUS77040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HD94"/>
    <dbReference type="STRING" id="188477.A0A3S1HD94"/>
    <dbReference type="OrthoDB" id="5788137at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003865">
        <property type="term" value="F:3-oxo-5-alpha-steroid 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160198">
        <property type="term" value="F:polyprenal reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102389">
        <property type="term" value="F:polyprenol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016095">
        <property type="term" value="P:polyprenol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039698">
        <property type="entry name" value="Dfg10/SRD5A3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14624">
        <property type="entry name" value="DFG10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14624:SF0">
        <property type="entry name" value="POLYPRENOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="71"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS77040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="227" mass="26038" checksum="EBFEC00ADB79C4D0" modified="2019-04-10" version="1">MVALVKKSLAVPAVLQDISRFLHWFEASDEVNPEQVQSCLPLLVVLVCEEFQLLRRMYECYFVSSFSDGTISIIHYFYGVAFYALFGFGTLLSLSLHHFPISDALNSSDVFYCCLGVLGFCVASYFQHKAIQTFAALRLKKKEKPAKGHYIPRGHLFHWVASPHYLCEILIYLSLCLITRGRNTYLVCATLFVVVNQVSASLSVHAWYRRTFRDFPKNRRALVPFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HMK5</accession>
    <name>A0A3S1HMK5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Scavenger receptor class B member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_009775</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000285">
        <property type="protein sequence ID" value="RUS82469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HMK5"/>
    <dbReference type="STRING" id="188477.A0A3S1HMK5"/>
    <dbReference type="OrthoDB" id="18585at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005428">
        <property type="entry name" value="CD36/SCARB1/SNMP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002159">
        <property type="entry name" value="CD36_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923:SF51">
        <property type="entry name" value="LYSOSOME MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01130">
        <property type="entry name" value="CD36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01610">
        <property type="entry name" value="CD36ANTIGEN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01609">
        <property type="entry name" value="CD36FAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS82469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="47227" checksum="502EEA6A2CA26574" modified="2019-04-10" version="1" fragment="single">GTPRTWSKQSCPPSSPSKKQNIIYTHTHTHTPDNPASVHAMASPKGSKLTKGLLVLAIIGAVFVILGCVALIISDGIIYSQVAATLPLNKKGQTYEQWKRPKIPIYFQVWAFDITNPLEILEGKKPAVVHKGPYTYREERTKHAIRFFENGTVYYKERRSFVFDRGLSVGSDNETVTSVNLAMATVMTALRYEAPLLKELVDGALQFWKEELFVETSVHDLLWGREDNILKAIADLVKSFNVTLPITDTVGLLMGKNNTDTGEYLIHSGQRGLENFANIVSWNRQRKLSVWSSDYANTINGSLGIFFPPFVDKDHEQYIFSTDLTRSLALTFQHQTETEGIPLYKFYAPPVTFAKPSINPLNAGFCTPPGHCLPSGLLNMSTAYFGAPVVVSNPHFLFCEPEVVASVEGIWPDREAYESHLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SKK0</accession>
    <name>A0A433SKK0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">fructose-bisphosphate aldolase</fullName>
            <ecNumber evidence="3">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_022659</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I fructose-bisphosphate aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="3"/>
    <dbReference type="EMBL" id="RQTK01001632">
        <property type="protein sequence ID" value="RUS69575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SKK0"/>
    <dbReference type="STRING" id="188477.A0A433SKK0"/>
    <dbReference type="OrthoDB" id="36455at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000741">
        <property type="entry name" value="FBA_I"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033379">
        <property type="entry name" value="FrucBisAld_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11627">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00274">
        <property type="entry name" value="Glycolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS69575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="352" mass="38073" checksum="6DFC61FB485BDCA9" modified="2019-05-08" version="1">MPKPTSRFTTYLTPAQEDELRKIANAIVAPGKGILAADESVGTMGKRLENINLPNTDENRRKYRELLFTADNVISNNVSGVILFDETFRQSTAAGVPFVKVLQDKGIIPGIKVDKGVVPLAGSLNECTTQGLDGLSERCAEYKKGGCGFAKWRCVLKISEHTPSHQAMMENANVLARYASICQQNGLVPIVEPEVLPDGDHDLETAQRVTEEVRLVYICCFRMPCSFTQTASIKKKKINRDPVSITFFLPLHLPPGITFLSGGQSEEDATINLNAINTYAGRKPWPLTFSYGRALQASVLKAWGGEDANIKAGQDELIRRAQANGAAAVGKYAGGGEGAAGGESLFVANHAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SN64</accession>
    <name>A0A433SN64_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_021555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001354">
        <property type="protein sequence ID" value="RUS70679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SN64"/>
    <dbReference type="STRING" id="188477.A0A433SN64"/>
    <dbReference type="OrthoDB" id="6160553at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019084603" evidence="2">
        <location>
            <begin position="25"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="758"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="908"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="589"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="610"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="628"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="695"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="784"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="807"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="818"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="908"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="931"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="958"/>
            <end position="971"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS70679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="971" mass="107172" checksum="70AC09156F6571CB" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SNF9</accession>
    <name>A0A433SNF9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_021458</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001335">
        <property type="protein sequence ID" value="RUS70779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SNF9"/>
    <dbReference type="STRING" id="188477.A0A433SNF9"/>
    <dbReference type="OrthoDB" id="1854502at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000003">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF205">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="407"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS70779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="55387" checksum="B61546C6894583E4" modified="2019-05-08" version="1">MESYPDMSSESDSEMSPNEARVYTTKTSPKRVAASHRRTASQDKLRALGKSASLDSASQQHGQQHGSDSSLSTIGGGTRQGGRKRRNKIPEKPNISLNLWSFMKNAIGKELSKIPMPVNFNEPLSMLQRIMEEMEYSEILDQAARCQDSAEQMAWVAAFTVSAYATTLFRVGKPFNPLLGETFEFDRMDDLGWRGISEQVSHHPPALAMHIEGKDWMTWQEFTMTTKFRGRYLQIVPMGIAHLVFPKTGHHYTWRKVVTTVNNVIVGNLWVDNHGEMEITNHHNGDKCHLKYSAYSYFSRDEPRKVTGVVTDKEGAAKWVLTGTWDQKMEAAQIVHKEESNKGKPVFETGPHRTMWKVRPPPPGAEKMYFFSQLAIEMNEAEDGVAPTDSRLRPDQRCMEDGRWDEANRVKVRLEEKQREARKLREAQAEKAKAEGRELAQYKPTWFRKERCSVMGGVMHRYNKLYWDCKARQDWSSCPDIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SPH3</accession>
    <name>A0A433SPH3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">U3 small nucleolar RNA-interacting protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">RRP9 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">U3 small nucleolar ribonucleoprotein-associated 55 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">EGW08_021117</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">EC2010</strain>
            <tissue evidence="21">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of a nucleolar small nuclear ribonucleoprotein particle (snoRNP) thought to participate in the processing and modification of pre-ribosomal RNA (pre-rRNA). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts specifically with the U3 small nucleolar RNA (U3 snoRNA). Binds a sub-fragment of the U3 snoRNA surrounding the B/C motif (3UBC). This association with the U3BC RNA is dependent on the binding of a protein called 15.5K to the box B/C motif. The association of the protein with the U3BC RNA was found to be also dependent on a conserved RNA structure that flanks the box B/C motif. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat RRP9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001269">
        <property type="protein sequence ID" value="RUS71126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SPH3"/>
    <dbReference type="STRING" id="188477.A0A433SPH3"/>
    <dbReference type="OrthoDB" id="189968at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000143">
        <property type="entry name" value="U3 small nucleolar RNA-interacting protein 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039241">
        <property type="entry name" value="Rrp9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7 19" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="19">
        <location>
            <begin position="85"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="19">
        <location>
            <begin position="138"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="19">
        <location>
            <begin position="180"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="19">
        <location>
            <begin position="222"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="19">
        <location>
            <begin position="263"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="19">
        <location>
            <begin position="314"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="21">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00065513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00074377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00076054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00077445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RUS71126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="414" mass="45941" checksum="753BB4CCD304246E" modified="2019-05-08" version="1" fragment="single">FTESRDKIYSSEEEEETAQQKKLRLAKQYLSKLEEEEAEKKADEETLKEAVASRLQHDISEQAGRLTKQIADQCQCPTESDIKTFRGHSLPVTAIVITPDDKFVFTASKDCNICKWSLETGLKVKTVKGGRKGTEDVHVGHTDHILCMAISSDGKFLAAGDMNNMVKLWNPVDCSFIHKFRGHRGPVTGVSFRKGAHTLFSCSQDRVVKVWNVDELAYVETLFGHNSPITSIDSLTRDRAITAGGSDKTVHVWKITEDSQLLFHGHNASIECVALVNEGNFFTGADDSSVSLWSVLKKKPMTTVKSAHNEHGNFTGSENWITAVAALHHTDLVASGSKDGFVRLWKCGPDFKTLKQVFKVPVTGFINSLKFSSNGDFLVAAVGQEHRMGRWWRLKEARNGWCVIPLKSTAANTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SRF2</accession>
    <name>A0A433SRF2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_020413</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001153">
        <property type="protein sequence ID" value="RUS71828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SRF2"/>
    <dbReference type="STRING" id="188477.A0A433SRF2"/>
    <dbReference type="OrthoDB" id="6138920at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF112">
        <property type="entry name" value="LD11247P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="DAGKc" evidence="6">
        <location>
            <begin position="179"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS71828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="531" mass="59628" checksum="255F8F433937BD00" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SSP0</accession>
    <name>A0A433SSP0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_020011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001094">
        <property type="protein sequence ID" value="RUS72238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SSP0"/>
    <dbReference type="OrthoDB" id="10631498at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS72238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="204" mass="23205" checksum="B36756B9ECBD8922" modified="2019-05-08" version="1" fragment="single">MRKIVLRPLNPPPKLDRYCHLSTEAQVTLAALEAKYDHLLKSFQRKEQSDSANYYKSIYDATFKRENERTLFRQSASRQLKINNYECRGTTKQASLKNSSAQSNNSAPKKDHDVFSELLVMDHPPDDEIAESILLFTQRTSAPESPLIDFESNIAEEHEQTATTSSKRTKFAQYLSQLDTDIIGANSSDAKKICLQSTNFHLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433STH8</accession>
    <name>A0A433STH8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_019667</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001050">
        <property type="protein sequence ID" value="RUS72581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433STH8"/>
    <dbReference type="STRING" id="188477.A0A433STH8"/>
    <dbReference type="OrthoDB" id="5981530at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016500">
        <property type="term" value="F:protein-hormone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002131">
        <property type="entry name" value="Gphrmn_rcpt_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF74">
        <property type="entry name" value="LP13728P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00373">
        <property type="entry name" value="GLYCHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="139"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="372"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="544"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="174"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="223"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="554"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="574"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="612"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="628"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="641"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS72581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="673" mass="72405" checksum="C7A68450FB6A59CD" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SUS5</accession>
    <name>A0A433SUS5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_019262</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000991">
        <property type="protein sequence ID" value="RUS72979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SUS5"/>
    <dbReference type="OrthoDB" id="7487361at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.220.10">
        <property type="entry name" value="Ganglioside GM2 activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036846">
        <property type="entry name" value="GM2-AP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF8">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63707">
        <property type="entry name" value="Ganglioside M2 (gm2) activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="174"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS72979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="398" mass="45287" checksum="8AA786D774FF96B3" modified="2019-05-08" version="1">MILVNRLGSVVLSKKLGSTWIKIPCIGVIGSCEYADVCDLLKNAECPPPFQAKNIPCKCPFNQPKSYLERRVHHLGDVHSEGDGQRAWEDHWIGSQNDVAHLGQICLGVSAVLEHGVCSSHGVEHRLPTQEVRGSSPTLVILSSFGWIIHSLISLNETGVQVSRYRLYAEAEYIFREIDTVPGLKINGENINNLRYADDTVLLAESQNDLQNLVIIIEEHSGKYGLLMNVKKTKKEPPKAEIKVKGKSIEQIDHFVYLGQLITTDGSETWTLNKSIEKRRDAMEMWMYRRMNRISWKDKVTNKEVLDKVGMQKPELLQLVQRRKLAYYGHIRRHCGIQKRVVEGKVEGKRGRGRKRQSWLANIQETSQLRLSVACEAALYRERWRRMTAHLGDGTAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SXF2</accession>
    <name>A0A433SXF2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LRRNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_018234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000876">
        <property type="protein sequence ID" value="RUS74005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SXF2"/>
    <dbReference type="STRING" id="188477.A0A433SXF2"/>
    <dbReference type="OrthoDB" id="6148273at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45617">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45617:SF170">
        <property type="entry name" value="MIP14966P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS74005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="19971" checksum="DA212279475B3292" modified="2019-05-08" version="1" fragment="single">VTPFPLPRKLEALYFSNLNLQYDIKKYEIVNNRVLSHLDLSANGIKGFYGPVYGVPSLRHLDLSRNYCFYVHPLFFSEMLSLRTLLLYNNKLGRSFAKDEEGITFSALALLEILDLSSNVIEDLPKATFKNNANLHLLNLSNNGLSQFQPTLVNQTNLQTLDLSYNFLKCFSKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SYQ3</accession>
    <name>A0A433SYQ3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Gamma-glutamylcyclotransferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_017792</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the gamma-glutamylcyclotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000830">
        <property type="protein sequence ID" value="RUS74454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SYQ3"/>
    <dbReference type="STRING" id="188477.A0A433SYQ3"/>
    <dbReference type="OrthoDB" id="113620at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061929">
        <property type="term" value="F:gamma-glutamylaminecyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039126">
        <property type="entry name" value="GGACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12510:SF4">
        <property type="entry name" value="GAMMA-GLUTAMYLAMINECYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12510">
        <property type="entry name" value="TROPONIN C-AKIN-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-glutamylcyclotransferase AIG2-like" evidence="4">
        <location>
            <begin position="9"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR639126-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS74454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="172" mass="19673" checksum="2B8A4F23B8A5E820" modified="2019-05-08" version="1">MSYGGKHIVFVYGTLKTGLRNHEVMTNPHEGLAKFLGSGETVLRYPMVVNEEFHVPFLLHREGEGEHIEGELYQVDDAKLSSLDHLEGHPHFYQRLVTRVKTSGKDFPPTVTSLADAGSVVEAWTYFIMSFRQELLDLPKLKSYSSTVIYKVAPEEMERRRLKLRMFVRGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SZD7</accession>
    <name>A0A433SZD7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_017563</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000809">
        <property type="protein sequence ID" value="RUS74683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SZD7"/>
    <dbReference type="OrthoDB" id="296522at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000028">
        <property type="entry name" value="potassium voltage-gated channel subfamily D member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF113">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019109961" description="Ion transport domain-containing protein" evidence="12">
        <location>
            <begin position="18"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="13">
        <location>
            <begin position="5"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS74683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="118" mass="12492" checksum="19A03F6CB41CCC01" modified="2019-05-08" version="1" fragment="single">MGAGVLLFGSALYIAEGFSTPDTEPLQFKSIPEAMWWAIITMTTVGYGDYYPVHAAGYVVGAVCAVSGLLLVAMPIAIVASNFSLFYDNMSSRDQSLRRQAMLGQMIGIAMATRGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T055</accession>
    <name>A0A433T055_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_017313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000785">
        <property type="protein sequence ID" value="RUS74933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T055"/>
    <dbReference type="STRING" id="188477.A0A433T055"/>
    <dbReference type="OrthoDB" id="6269447at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098998">
        <property type="term" value="C:extrinsic component of postsynaptic early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098837">
        <property type="term" value="C:postsynaptic recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098887">
        <property type="term" value="P:neurotransmitter receptor transport, endosome to postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905244">
        <property type="term" value="P:regulation of modification of synaptic structure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099152">
        <property type="term" value="P:regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099158">
        <property type="term" value="P:regulation of recycling endosome localization within postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026204">
        <property type="entry name" value="GRIPAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18978">
        <property type="entry name" value="GRIP-1 ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18978:SF1">
        <property type="entry name" value="GRIP1-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS74933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="239" mass="28015" checksum="7C798D01DD9DBBB0" modified="2019-05-08" version="1" fragment="single">VQEAKKAATDAVTDLQAAQAERDKQITALQEVNKVAEKRKSLLDELAIKYQKEYDSHREDVTKAKEKHDEEVDKLQQELEAQKKTVSHLNRQLPMIEELNKKVASLEESKGWLERRLSETEEQLAATVAAHEQEKSDLMEKHAAERRELEASHLVEMEGHRKEKERAEEEWRKKEEALQEDLKSLKNKSNNLKQEILDTEDKKKIHEKKGMTMMKDLKRQLHAERRRAEKLQAKLQEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T1I6</accession>
    <name>A0A433T1I6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_016833</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000745">
        <property type="protein sequence ID" value="RUS75394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T1I6"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS75394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="118" mass="12982" checksum="7FA2A156BC961E0C" modified="2019-05-08" version="1" fragment="single">ANDVLKPARQCDCILVLIDQLVNDPLGSRAVALQVIPQPRSLRLRALSIQVRIERERRAAEPIVDCRPISAASVRLVIISRRTLPPAAPAQEALQLCGESNQDLGRVRQSGTRLGHHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T1W0</accession>
    <name>A0A433T1W0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">snRNA-activating protein complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_016683</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000730">
        <property type="protein sequence ID" value="RUS75558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A433T1W0"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051575">
        <property type="entry name" value="Myb-like_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621:SF1">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="19"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="77"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="132"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="132"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="191"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="628"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="832"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="896"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="967"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1006"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1195"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1419"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="641"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="689"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="727"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="739"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="840"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="967"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="982"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1020"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1091"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1202"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1224"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1253"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1327"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1338"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1382"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1451"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1481"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS75558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1490" mass="167762" checksum="0A43EE8B8F3F9F67" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T3M2</accession>
    <name>A0A433T3M2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MRN complex-interacting protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_016081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000683">
        <property type="protein sequence ID" value="RUS76169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T3M2"/>
    <dbReference type="STRING" id="188477.A0A433T3M2"/>
    <dbReference type="OrthoDB" id="5960226at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032739">
        <property type="entry name" value="MRNIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049472">
        <property type="entry name" value="MRNIP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15863">
        <property type="entry name" value="MRN COMPLEX-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15863:SF2">
        <property type="entry name" value="MRN COMPLEX-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15749">
        <property type="entry name" value="MRNIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MRN complex-interacting protein N-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS76169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="159" mass="18111" checksum="E7F8088D5C150698" modified="2019-05-08" version="1" fragment="single">VVFHVLRCAKCDTFQVLQVTKSKKWTCKLCGLKQSVIKVFGEGTGAECRHHVQKLNTLRGQADQILEEKHLINVTEPEESASQHRPTSPAEPSRVLDSSGSRWSSYLDDRDDCEESEVSTETRSSDVGGLRGHVTTDWGEFTKRKREFQAESQKRKMFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T492</accession>
    <name>A0A433T492_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_015839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000665">
        <property type="protein sequence ID" value="RUS76409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T492"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS76409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="270" mass="30230" checksum="7BFF0D46C8F27455" modified="2019-05-08" version="1">MSKRVYEGDAGRSGCHEPMITECPLSVRAPIICPKALMCLGLTAWTLGRLAVWPHGIDPPRANPGRYLEAISVTPNATSHKPHATRHTPHATSHKPSKVGSLNEHRWCKNCKPSLELDARNAVGCVQGVHWTQHWTLLDINETLSWTTESGRLDIAVHGTVNQNVGFSREHNSLGFGEFDEFSLVHRVGRREKRGDRQKDGYADGYWEIENNMWRKLKNSLFIENMGLLRAAAELRLPVQVVEEMLVVEAIESETVRCLMVNLGVALNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T614</accession>
    <name>A0A433T614_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_015331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000625">
        <property type="protein sequence ID" value="RUS76892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T614"/>
    <dbReference type="STRING" id="188477.A0A433T614"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS76892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="239" mass="26923" checksum="F8000AACCF1BBBC3" modified="2019-05-08" version="1" fragment="single">WQHNHSKCKVCPITGLWRHNQSESKVCPTTGLWQHNHSKCKVCPTTGLWRHKQGKGKVCPTTGLWRHKQGKGKVCPTTGLWRHKQGKGKVCPTTGLWRHKQGKGKVCPTTGLWRHKQGKGKVCPTTGLWQHNYSKCKVCPTTGLWRHKQGKGKVCPTTGLWRHKQGKGKVCPTTGLWRHKQGKCKVCPTTGLWRHKQGKSKVCPTTGLRRHTQGKSKVCPKTGLWRHNQGKSKVCHTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TA76</accession>
    <name>A0A433TA76_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein WDR12 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_013769</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR12/YTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000507">
        <property type="protein sequence ID" value="RUS78481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TA76"/>
    <dbReference type="STRING" id="188477.A0A433TA76"/>
    <dbReference type="OrthoDB" id="10251381at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03029">
        <property type="entry name" value="WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028599">
        <property type="entry name" value="WDR12/Ytm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF11">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="8">
        <location>
            <begin position="13"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="196"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="267"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="349"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS78481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="427" mass="47640" checksum="34E2E3E4157C2C3D" modified="2019-05-08" version="1">MASEASLGSTSHVQAKFFTKQTEYSIPDVPYSLPISVSPKELNDIVHSVLYEGDGEKTASFDFLINGELLRSTLEVYLEDKDISIESVLEIEYIERQAAPRPEASLSHDDWISSVRGNNNLILCGCYDNTIKLWSRDGQCLTTIPGHSGPVKCVTWLRSTGDEEDEHLFASGSHDQSAFVWRWKASKKEIDCLYAFRGHSGSVDCIAANADGERVVTGSWDKTIKLWTADNNSTEQKETEDSETLQQAKKLKSGGHKMVTRVPLLTVGGHKEAVSAAVWLDDSTVCSASWDHTMRVWDMTRAEQTQIVEGSKAFFQIAHSRLSNLIVSASADRHVRLHDLRTKEMKGTYTSHAGWVSGVDWSKTDEHLFVSGSHDCLMKLWDTRSPKAPLYNMIGQEEKILAVDWSIPDLMLSGGADNQLKMFNYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TAD3</accession>
    <name>A0A433TAD3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_013670</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000502">
        <property type="protein sequence ID" value="RUS78563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TAD3"/>
    <dbReference type="STRING" id="188477.A0A433TAD3"/>
    <dbReference type="OrthoDB" id="8113227at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000512">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001289">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376:SF243">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="38"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="257"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS78563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="510" mass="55357" checksum="E2395BC6E5377112" modified="2019-05-08" version="1" fragment="single">MDSYEALMSNPMASGYPMAHQNNFPPFSDSSGYGHLGDMPGSFSDSPRTMGGGMVGLRGAFPNTSSSSGYGSLPPHSSASFAMPYDPPNIQQPQQHQIHNGGGGGSGSSSGGGGGGVNQAHSMQMPPMPQIPHSSPAPTSNKTIHSCTYCGLVLSSANALIEHKRIHTGDRPFGCHICGKRFTQKAHLNIHKRTHTGEKPYACNICNKRFAQSSHLVSHKRIHTGEKPFVCGICHIGFTQKQRLDAHLKKHLLQGGLQGGTEEMGASRRKPAVVRKLPMGSPPNAEPRNPEAAEGAGQFQRFSPLHGAPDTSLGPPPPPSEMEDFHDQGETVDDKDDPPYHGNASRKPNTPGMMTRRGSMPLQDQPDSKYAQDRNFNAFGSQSQYGPYHPGTNGIEKRQAPAVQQETLSYCSPKVSADSGPLAGGSGGEHVKVNNRVSLVNFTAEELLTHLMKRDDVNKCQFCCIIFQDPAMYHIHRNMHDRSDLRRCNMCGKMLADKYDFTAHFLSMHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TBB6</accession>
    <name>A0A433TBB6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_013428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000488">
        <property type="protein sequence ID" value="RUS78810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TBB6"/>
    <dbReference type="OrthoDB" id="6096918at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS78810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="451" mass="49485" checksum="26397A7CEED757A4" modified="2019-05-08" version="1">MTENQSPWLSTKHPPKQTVNGKRQRMSKGPLSRKTPPLQMISSPSSIARLTQNSPPPVQLKLARKQSSLLEYFGSAGKNGDSPSSVPAQRKRKLEIDDPDVIQIKTECFKDSHHGQSAGNSCCDASLKTWHRPLYPLKSLEPVTSTCGTVTHPDGCEESMDSLIQGDSCYKYETSSSNRPHNKTSPLKEIQVACLPEPSVTCLRSPEKPLDTDIGKHSSNFSPSESSCVRNLVSSESSRIFTEQSGSVSSESTSLSKVLAQKQSVATQDDFSDNLECIESISDMKNSFSKHTSKNESEKIIYEDDKFSVESFTLNVSDSVEIESSNEGKLLVNCEDNDAGIREKEGSKEQDINFDSQNSEMTSPSRSPNCAWSIPSVQGDLNVSSDSCLLSFTEDSQSLHFTETVAEGINSTSCTADQIYGDAMNRLDILKAQHMAEMGTLTFTQTQNFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TEX3</accession>
    <name>A0A433TEX3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_012117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000410">
        <property type="protein sequence ID" value="RUS80118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TEX3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS80118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="524" mass="55094" checksum="C25014885943EC47" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TF38</accession>
    <name>A0A433TF38_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">KxDL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_012071</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KXD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000407">
        <property type="protein sequence ID" value="RUS80182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TF38"/>
    <dbReference type="STRING" id="188477.A0A433TF38"/>
    <dbReference type="OrthoDB" id="10258877at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099078">
        <property type="term" value="C:BORC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032418">
        <property type="term" value="P:lysosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039843">
        <property type="entry name" value="KXD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019371">
        <property type="entry name" value="KxDL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13511">
        <property type="entry name" value="KXDL MOTIF-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13511:SF0">
        <property type="entry name" value="KXDL MOTIF-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10241">
        <property type="entry name" value="KxDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KxDL" evidence="3">
        <location>
            <begin position="27"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="174"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS80182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="216" mass="24331" checksum="DEBD39227489C3CB" modified="2019-05-08" version="1">MASREHEPDRDKAMPSHDDATTFAASLINQVNREDIPQMVYIQRDMLGRFEKTNEMLINFNMLSSGRYEATLKEFQQHTQLLFDMKKDLNSIFRRHRVVKSRLEKSYPDAFAACSHTYTVSSDDEDVEDKDHGNEAGGETKTEVNNVLPAATEYSQSNEQRVPIYGSQGAKVQREFPVPKSTGPVVNVTPAGSNLESGTSEASKKKLYKLQPNPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TFS6</accession>
    <name>A0A433TFS6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_011856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000394">
        <property type="protein sequence ID" value="RUS80391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TFS6"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS80391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="176" mass="19049" checksum="1388D4846DD0572B" modified="2019-05-08" version="1" fragment="single">TEEFTEEDFQKPTEQNGKGRPPTDQLLSTAPTSYATKTNANQTWRPSTLTGYDLYDPSDLQIHRLVPGVMRAGLGGISGGGALGGGGVGGSYSLHDIDTSLVTLHERMQNFESELCETVDAILNLLGHKPRMTKDALDQLAPISSASGVRGHRPLRSRLESRQQRSGSDEETPLMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433THR7</accession>
    <name>A0A433THR7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">small monomeric GTPase</fullName>
            <ecNumber evidence="3">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_011165</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="3"/>
    <dbReference type="EMBL" id="RQTK01000356">
        <property type="protein sequence ID" value="RUS81079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433THR7"/>
    <dbReference type="STRING" id="188477.A0A433THR7"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04112">
        <property type="entry name" value="Rab26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000459">
        <property type="entry name" value="ras-related protein Rab-37 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0636">Prenylation</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS81079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="216" mass="24462" checksum="689F46A553BD8654" modified="2019-05-08" version="1" fragment="single">MGKNRGQTDITTNGDAKQNANRQFSVMEAYDLSCKVMLIGDSGVGKTCLLVRFKDGTFLSGSFISTVGIDFRNKVVDLEGTKVKLQIWDTAGQERFRSITRAYYRDANALLLLYDVTNKNSFDNIRAWLGEIQEYAQDDVVIMLLGNKCDCHERVIKKEDGDRLSKEYGVAFMETSAKTGMNVELAFMAVARDLKMKKQRRPNEPRFDVAAYVDHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433THW5</accession>
    <name>A0A433THW5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_011080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000352">
        <property type="protein sequence ID" value="RUS81172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433THW5"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS81172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="225" mass="24454" checksum="9E5771748BB91BDE" modified="2019-05-08" version="1">MVTTHVHTITLIKVGEKGRQLQLQLQGPDDHAGSVGQVTVRAVSRALPRDQWFYLVYETAGPPGPAVQAQDGDLRLSEQAQTGALLSESTFLTSNLSLIVIEPIRDCDQSTCPTDGRPDTHKRPSGGHLTWVVSDRPGVSESNYRASEVAREETRRAPKALTPVCTTYQTNRCPTLAKAGTTPTPSNNHQNLLTGAEVKSVPQSYPDVLAKTEECLVERESPAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TK31</accession>
    <name>A0A433TK31_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_010274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000312">
        <property type="protein sequence ID" value="RUS81959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TK31"/>
    <dbReference type="OrthoDB" id="6125087at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019545037" evidence="1">
        <location>
            <begin position="29"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS81959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="102" mass="11187" checksum="83CAA280ACDFFC67" modified="2019-05-08" version="1">MFLRASTLTQIGVAILVVSLCNMDVVSAVGNTLHRSKRGFRQNSASRVAHGYGKRGSSLLSLNSRINLPLADDQQQMQDRLLPKIGFEELPEFSLGLEEDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TKJ0</accession>
    <name>A0A433TKJ0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_010129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000302">
        <property type="protein sequence ID" value="RUS82117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TKJ0"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS82117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="106" mass="11281" checksum="D1433D46D77598D7" modified="2019-05-08" version="1" fragment="single">MRSRWPPSPSSSSPYSSPSSSSASSLSSSWCLRCLLLSLADPPPPPPPPPPPPPKTSSKEDFEEEESLWPKFAESFPGMKTLACLRSSTSRSSSSPSRSSNTLPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TM62</accession>
    <name>A0A433TM62_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_009639</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000279">
        <property type="protein sequence ID" value="RUS82611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TM62"/>
    <dbReference type="STRING" id="188477.A0A433TM62"/>
    <dbReference type="OrthoDB" id="10257471at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20933:SF4">
        <property type="entry name" value="F-BOX INVOLVED IN POLYQ PATHOGENESIS, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20933">
        <property type="entry name" value="F-BOX ONLY PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="91"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="580"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS82611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="616" mass="67584" checksum="46067CD18F8BE5B6" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TN51</accession>
    <name>A0A433TN51_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">VWFD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_009298</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000264">
        <property type="protein sequence ID" value="RUS82961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TN51"/>
    <dbReference type="STRING" id="188477.A0A433TN51"/>
    <dbReference type="OrthoDB" id="6287323at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050780">
        <property type="entry name" value="Mucin_vWF_Thrombospondin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014853">
        <property type="entry name" value="VWF/SSPO/ZAN-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339">
        <property type="entry name" value="EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339:SF395">
        <property type="entry name" value="GH18 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08742">
        <property type="entry name" value="C8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00832">
        <property type="entry name" value="C8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019451168" description="VWFD domain-containing protein" evidence="4">
        <location>
            <begin position="28"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="106"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="6">
        <location>
            <begin position="223"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="6">
        <location>
            <begin position="599"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS82961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="786" mass="84679" checksum="11B9D90EAAD0DC76" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TNA4</accession>
    <name>A0A433TNA4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_009206</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000261">
        <property type="protein sequence ID" value="RUS83018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TNA4"/>
    <dbReference type="OrthoDB" id="6101985at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052983">
        <property type="entry name" value="MFS_Riboflavin_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43385">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER RIBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43385:SF1">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER RIBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="272"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS83018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="506" mass="55877" checksum="723411556B0F4A6C" modified="2019-05-08" version="1">MHSYHKVLVVTGASLVASPLSMANYFGNLLPYLASYNYAHRDQMNIYMDPLYTASVFTCTFIISMIFTSPIELRFGIRPCILASDMLLWVSLMSGYFTVQEPLALTLIFGGLQGIAVGVLYSLATKVLLQTMLKQSGLSTGIMSVGMVFGTFLSIGVAFAVINPENKEPDLRVDNQVYFSDKDLIDRVPFYFLIAGAVMVCVNILGTVLMFVGSSNTGQVDQDQIFSETTPISRQICELNHESIAIAISESDKSAFLESTGPLDARHLRQPKNGSSYTHGSHSSMVGVSTDEKQMENSTEKMNGNPKLFTQTEISPGKAIKTPQFWCVWLGYVSSHHTSYLYQNLYKQYGQRVFPNDAWLTTNGLISNAGMAIVCMFVGAGSDKFGIRTMNVLFNAASSVFMCLMVVSVHTWPLTYMALVIIENLAVSPHTMLFTLLSAFEFGNTHCASNMGLIRTGNLMLMLIEPFIVDEMLRAMGWDWVFFSGALTSAIATVSVIMLDVCKREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TPR2</accession>
    <name>A0A433TPR2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_008736</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000241">
        <property type="protein sequence ID" value="RUS83486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A433TPR2"/>
    <dbReference type="OrthoDB" id="6067113at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="41"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="861"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="119"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="436"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="699"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1277"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1319"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="124"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="699"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1319"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1362"/>
            <end position="1383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS83486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1600" mass="178294" checksum="EC1809070B3E50C6" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TQF8</accession>
    <name>A0A433TQF8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Voltage-gated potassium channel subunit beta-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">K(+) channel subunit beta-1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Kv-beta-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">EGW08_008501</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">EC2010</strain>
            <tissue evidence="19">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15937"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:15939"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a secondary alcohol + NADP(+) = a ketone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19257"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17087"/>
            <dbReference type="ChEBI" id="CHEBI:35681"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:19259"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000232">
        <property type="protein sequence ID" value="RUS83750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TQF8"/>
    <dbReference type="STRING" id="188477.A0A433TQF8"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015459">
        <property type="term" value="F:potassium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901379">
        <property type="term" value="P:regulation of potassium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005983">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005400">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01293">
        <property type="entry name" value="Kv_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150:SF2">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01578">
        <property type="entry name" value="KCNAB1CHANEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01577">
        <property type="entry name" value="KCNABCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0630">Potassium</keyword>
    <keyword evidence="8" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="18">
        <location>
            <begin position="2"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RUS83750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="340" mass="38843" checksum="18954B8A961C8F44" modified="2019-05-08" version="1" fragment="single">VAEELLTVAYDRGINFFDTAEVYSGGKAEIVLGKILKKKQWRRSSYIISTKIYWGGKAETEKGLSRKHILEGVQASLSRLQLDYVDIVFANKADSHVPMEEIVRAMTFVINQGWAMYWGTSRWSTMEIMEAYSVSRQFNLIPPVAEQAEYHYFQREKVELQMPEMYHKIGVGTITWSPLACGILTGKYDDGIPIYSRAALKGYNWLRERILSEDGRRQQAKLRDIAVIADQLGCSLAQLAIAWCVRNENISQVLLGASSVEQLCEDIQALQYVPKLTAPLMEEIERILGNKPLTRDYYSIHRRSSASSESRPKMNLKTDSAHRQFLRNFSLAKIFPWGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TRB7</accession>
    <name>A0A433TRB7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prokineticin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_008080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000216">
        <property type="protein sequence ID" value="RUS84152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TRB7"/>
    <dbReference type="OrthoDB" id="10212836at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.80.10">
        <property type="entry name" value="Lipase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019496642" description="Prokineticin domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS84152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="10722" checksum="093A2B1D2C755516" modified="2019-05-08" version="1">MLRAATFTILAFVALSLCVNSISACYSDSNCGDNECCQGLSMLPGSVGFCQPYVKVGGKCITFDDYTGICGCAPYLICTSVNTTGAWEREGICQIKPGNIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TRZ6</accession>
    <name>A0A433TRZ6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Neurotransmitter-gated ion-channel ligand-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_007905</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000209">
        <property type="protein sequence ID" value="RUS84311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TRZ6"/>
    <dbReference type="STRING" id="188477.A0A433TRZ6"/>
    <dbReference type="OrthoDB" id="6148344at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18989">
        <property type="entry name" value="LGIC_ECD_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="3">
        <location>
            <begin position="5"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS84311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="140" mass="15919" checksum="B7AE9CDD06E7EC62" modified="2019-05-08" version="1" fragment="single">CAQILRWNASDYGGVASISPRAGQVFTPRINLMNTMGERDLFTEDFSPMNVYNNGFTVWVPGSIFVVFCKLDLSKYPFDEQICRIEMVLMNFDSSKVRFQTADYTATREFYQENEEWDLLGSLVKSTVTVVSNNSLPSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TUR0</accession>
    <name>A0A433TUR0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenylate kinase 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_006980</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000176">
        <property type="protein sequence ID" value="RUS85279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TUR0"/>
    <dbReference type="STRING" id="188477.A0A433TUR0"/>
    <dbReference type="OrthoDB" id="10262413at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019205">
        <property type="term" value="F:nucleobase-containing compound kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22967">
        <property type="entry name" value="DD_AK7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047499">
        <property type="entry name" value="DD_AK7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007858">
        <property type="entry name" value="Dpy-30_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05186">
        <property type="entry name" value="Dpy-30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="612"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="425"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="627"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS85279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="730" mass="84522" checksum="2EA2FF5094300644" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TUS2</accession>
    <name>A0A433TUS2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_006936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000175">
        <property type="protein sequence ID" value="RUS85289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TUS2"/>
    <dbReference type="OrthoDB" id="6156038at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS85289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="182" mass="20551" checksum="091CFB84518D98BA" modified="2019-05-08" version="1">MNISNTMNLPPNTFRRVLTEHGRSSAPGLLESPMTPELKTRRRLQPRDKEVTDSLLKMATNPSEASNAKKDLPPSAESELASKIDKHAPFQYPEVSADNKHRIKTPVSKIRNTSASSPNGSFSFYKRSFRVNGKQAWEYAMRDLGSIDTLNNRYGYVEPHQRQDITPLKRPLGQTTKNNAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TY41</accession>
    <name>A0A433TY41_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_005749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000137">
        <property type="protein sequence ID" value="RUS86499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TY41"/>
    <dbReference type="OrthoDB" id="9217647at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS86499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="146" mass="18761" checksum="FF25CDF0CE6432D6" modified="2019-05-08" version="1" fragment="single">RERQNDIDRERQNDIDRERQNDIDRERQNDIDRERQNDIDRERQNDIDRERQNDIDRERQNDIDRERQNDIDRERQNDIDRERQNDIDRERQNDIDRERQNDIDRERQNDIDRERQNDIDRERQNDIDRERQNDIDRERQNDIRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TZJ2</accession>
    <name>A0A433TZJ2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_005230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000122">
        <property type="protein sequence ID" value="RUS86992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TZJ2"/>
    <dbReference type="STRING" id="188477.A0A433TZJ2"/>
    <dbReference type="OrthoDB" id="8947651at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS86992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="160" mass="19759" checksum="F5810B734AC52F2D" modified="2019-05-08" version="1" fragment="single">MSTSDETQIFLFSYRCDETQIFLFLYRCDETQTFLFSYRCDETQTFLFSYRCDHTQTFLFLYRCDDTQTFLFSYRCDDTQTFLFSYRCDDTQTFLFSYRCDETQTFLFSYRGEETQTFLFSYRCDETQTFLFSYRCDETQTFLFSYRCDETQTFLFLCLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U1C6</accession>
    <name>A0A433U1C6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MH1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_004564</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000104">
        <property type="protein sequence ID" value="RUS87641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U1C6"/>
    <dbReference type="STRING" id="188477.A0A433U1C6"/>
    <dbReference type="OrthoDB" id="5794312at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071144">
        <property type="term" value="C:heteromeric SMAD protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070411">
        <property type="term" value="F:I-SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032924">
        <property type="term" value="P:activin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060395">
        <property type="term" value="P:SMAD protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.520.10">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013790">
        <property type="entry name" value="Dwarfin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003619">
        <property type="entry name" value="MAD_homology1_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013019">
        <property type="entry name" value="MAD_homology_MH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036578">
        <property type="entry name" value="SMAD_MH1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703:SF53">
        <property type="entry name" value="MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703">
        <property type="entry name" value="SMAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03165">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00523">
        <property type="entry name" value="DWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56366">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51075">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MH1" evidence="8">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="92"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS87641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="139" mass="15810" checksum="8C94406C97279346" modified="2019-05-08" version="1" fragment="single">RSLDGRLQVFHRKGLPHVIYCRLWRWPDLQNHQELQPGDRCEFAFHLKKDEVCVNPYHYTRVDVALPQVLVPRHKDIPDNFPARLDEFSTTIPENTDLPSGSTAINDTVFNASDTPSPGYLSEEGDTTDSQGMGEYLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U226</accession>
    <name>A0A433U226_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_004400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000099">
        <property type="protein sequence ID" value="RUS87867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U226"/>
    <dbReference type="STRING" id="188477.A0A433U226"/>
    <dbReference type="OrthoDB" id="10067827at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19701">
        <property type="entry name" value="bHLH_TS_HEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000027">
        <property type="entry name" value="Nescient helix-loop-helix 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040238">
        <property type="entry name" value="TAL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13864:SF10">
        <property type="entry name" value="HELIX-LOOP-HELIX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13864">
        <property type="entry name" value="T-CELL ACUTE LYMPHOCYTIC LEUKEMIA/STEM CELL LEUKEMIA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="2" id="KW-0221">Differentiation</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="318"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="234"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="266"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="309"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS87867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="377" mass="41431" checksum="6ED62CF13A2E1453" modified="2019-05-08" version="1">MRFLECCVEQPVPNKPLEMKQLMASQEQRDLCPMATTAAMTLTLAHLPTSGPGSASVTCADSNHMLLSPPSPFEFCSGDALEENDLNLQNLQFFAQPPKQHHLDFEYGHDRVATTSSLTSSLSENFLRYPSSPPSHHLDQGFMCHNQPIMETGSSSCSGSPLSSFEDCFTPTSAISSNIHGKPVNHRLASSCALSAQSMLPHQVQLLPPTTPPPTSAVSAQTVPARMVSKNHHSYSLNPLAPHHQTTHSKPTKARLASGTGSLKANQNNNINDNNNNNNNHNSGTGNSKSPGEITPTKESLGHLSREERRRRRRATQKYRTAHATRERIRVEAFNVAFSDLRKLLPTLPPDKKLSKIEILRLAICYISYLNDVLDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U445</accession>
    <name>A0A433U445_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_003689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000079">
        <property type="protein sequence ID" value="RUS88589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U445"/>
    <dbReference type="STRING" id="188477.A0A433U445"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS88589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="25278" checksum="9A422CA408C1303E" modified="2019-05-08" version="1" fragment="single">SPSLFVNLSLSFFLSFSISSSIPLSLSIYLPLSISIHLSTYLFISITLSPFLSLALFLTQLLFLFVTLRLSLVLAMSLPLCLFLSTYLSIFPFPSHSGSISPYLYFSFPLTPSPFSIPPPTLSIYLSIYLPIYLTVCLSVCLSVCLSVCLSVCLSVCLSVCLSIYLSIYLSIYLSIYLSIYLSIYLSIYLSIYLSIYLSIYLSIYLSIHLYIYLSIYICINLSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U575</accession>
    <name>A0A433U575_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Ribophorin-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_003369</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits. STT3A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the STT3A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The STT3A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes. Interacts with DDI2. Interacts with TMEM35A/NACHO.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SWP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000071">
        <property type="protein sequence ID" value="RUS88930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U575"/>
    <dbReference type="STRING" id="188477.A0A433U575"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055373">
        <property type="entry name" value="Ribophorin_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008814">
        <property type="entry name" value="Swp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640">
        <property type="entry name" value="RIBOPHORIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05817">
        <property type="entry name" value="Ribophorin_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribophorin II N-terminal" evidence="3">
        <location>
            <begin position="111"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00046750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS88930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="250" mass="27357" checksum="C835A4F6E668CCEC" modified="2019-05-08" version="1">MVDYGLEVAIFFVIRNSRPSTNQTKRSAELAAVELFDVRCRLLRINMDRIHPVRANGFYVLFKHIADNRIDDHDHCDDDGDGSSCFSSVPGRSPVCQLSSWAHGLIPSTYITGADKDRLKSVFQSASPFVDSQSAHFSILGLKLLGVTTPNAQDACKILSKVVENKVVSIYHASEAAKALGSCKIDVPEFKQTLTDAIKDDSSVQDIAFAFLALKNLGLPADDAAVSKALLAALLSQPTMLLSARLYWQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U7M7</accession>
    <name>A0A433U7M7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_002379</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000046">
        <property type="protein sequence ID" value="RUS89849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U7M7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS89849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="100" mass="11332" checksum="A6FEC6B329B4823E" modified="2019-05-08" version="1">MHTYTPTKVNEIETLPSYNKENENKENESVVLIELMFLGERDQVVERWSANWEVPVSESTIGEYCICPILFPFRWVGVSLMCPAETGIRVSPHPLGCGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U8Q3</accession>
    <name>A0A433U8Q3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transgelin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_002076</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the calponin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000038">
        <property type="protein sequence ID" value="RUS90197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U8Q3"/>
    <dbReference type="STRING" id="188477.A0A433U8Q3"/>
    <dbReference type="OrthoDB" id="21595at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000557">
        <property type="entry name" value="Calponin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF14">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00402">
        <property type="entry name" value="Calponin"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01052">
        <property type="entry name" value="CALPONIN_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51122">
        <property type="entry name" value="CALPONIN_2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="24"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS90197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="947" mass="100659" checksum="078D78AC98918985" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UBC3</accession>
    <name>A0A433UBC3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_001139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000018">
        <property type="protein sequence ID" value="RUS91114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UBC3"/>
    <dbReference type="OrthoDB" id="6381815at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.20">
        <property type="entry name" value="Insect antifreeze protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36162">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36162:SF20">
        <property type="entry name" value="GLUTAMINE-RICH PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS91114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="247" mass="26725" checksum="6F4145D2BDEF1F4A" modified="2019-05-08" version="1" fragment="single">EPTTTNRSTLEPTTTCINRLTLEPTTINSSTLEPTTINRSTLEPTTINRSTLEPTTINSSTLEPTTINRSTLEPTTTNRSTLEPTTTNRSTLEPTTITCSTLEPTTINSSTLEPTTINSSTLEPTTINSSTLEPTTINRSTLEPTTTCINSSTLEPTTINSSTLEPTTINSSTLEPTTINRSTLEPTTINRSTLEPTTTNRSTLEPTTTNRSTLEPTTTNRSTLEPTTTNRSTLEPTTINSSTLEPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UCB2</accession>
    <name>A0A433UCB2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_000763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000011">
        <property type="protein sequence ID" value="RUS91439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UCB2"/>
    <dbReference type="OrthoDB" id="9944412at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS91439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="202" mass="21833" checksum="65B8032E7ED07147" modified="2019-05-08" version="1">MLLTAALLPCRSARNFLSTALRHQWSAVTSATSSQRFSLRPQPHAASVRPIHTGRGLRQAQGDQSQDKNAQLLSQMNIRLVCENGFLSWCRNTYISAVVGVAMMGEGASALAQSAGLGALLVGAMNLAWGTGCHVTNLVRLRHVSGMSRVTLFLHVSGSLLHCALWAFVLVCFIGFLDEARWPADPEDQDRHGTGGTPGRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UDB4</accession>
    <name>A0A433UDB4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">c-SKI SMAD4-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_000322</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000004">
        <property type="protein sequence ID" value="RUS91920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UDB4"/>
    <dbReference type="STRING" id="188477.A0A433UDB4"/>
    <dbReference type="OrthoDB" id="3938623at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046332">
        <property type="term" value="F:SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030514">
        <property type="term" value="P:negative regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21080">
        <property type="entry name" value="DHD_Skor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.390.10:FF:000001">
        <property type="entry name" value="SKI family transcriptional corepressor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.20:FF:000003">
        <property type="entry name" value="SKI family transcriptional corepressor 1 homolog-B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.390.10">
        <property type="entry name" value="SAND domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.20">
        <property type="entry name" value="Ski"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014890">
        <property type="entry name" value="c-SKI_SMAD4-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010919">
        <property type="entry name" value="SAND-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003380">
        <property type="entry name" value="SKI/SNO/DAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037000">
        <property type="entry name" value="Ski_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023216">
        <property type="entry name" value="Tscrpt_reg_SKI_SnoN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10005:SF26">
        <property type="entry name" value="CORL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10005">
        <property type="entry name" value="SKI ONCOGENE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08782">
        <property type="entry name" value="c-SKI_SMAD_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02437">
        <property type="entry name" value="Ski_Sno_DHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01046">
        <property type="entry name" value="c-SKI_SMAD_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63763">
        <property type="entry name" value="SAND domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="c-SKI SMAD4-binding" evidence="8">
        <location>
            <begin position="118"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="213"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="438"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="488"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="492"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="532"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="556"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS91920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="591" mass="64100" checksum="3AC37D695EAD6816" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UDM7</accession>
    <name>A0A433UDM7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_000423</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000005">
        <property type="protein sequence ID" value="RUS91852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UDM7"/>
    <dbReference type="OrthoDB" id="6146284at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF230">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS91852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="37561" checksum="18E2AFE6A480CEB7" modified="2019-05-08" version="1">MKYFRWCMLIPCCISIVSSGTIVGIIGDNSFQLYGKKMAIALNSIEGIKCLLFAFNRSWKAYASGHILTFNSSYSQYFICVVMWLPSAIGRMGILLNCAIAVERFFIIAFPIKFHKKRLIKHENVCIMVITISMLLYQMSPVILFIMYFKPYLDYSKTFGSDDVSSIIVDVNPEKFELYTLVHLVGAILFRLTPTAVTIIFNIVAAIKLYRQSKRRRILVNNTAPVSSRKIGSSQTNRMLLISSFLYALMTTLKPLNNSLRLVIPTYGEGRMNVFIYHICNDACLLLDNLIPLQNLIVYSYFSTQFSEHLKALRRCQKRRWNSPPPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZKI4</accession>
    <name>A0A3S0ZKI4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_015251</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000619">
        <property type="protein sequence ID" value="RUS76994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZKI4"/>
    <dbReference type="STRING" id="188477.A0A3S0ZKI4"/>
    <dbReference type="OrthoDB" id="6149986at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF300">
        <property type="entry name" value="PICKPOCKET PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 11" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="9 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="47"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="284"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="326"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="344"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="397"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="407"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS76994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="725" mass="80230" checksum="EDBC5EC56FE6DFE2" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZL41</accession>
    <name>A0A3S0ZL41_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_010756</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000336">
        <property type="protein sequence ID" value="RUS81458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZL41"/>
    <dbReference type="STRING" id="188477.A0A3S0ZL41"/>
    <dbReference type="OrthoDB" id="10071887at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF199">
        <property type="entry name" value="IP13425P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="570"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="611"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="83"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="409"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS81458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="683" mass="75218" checksum="62B306CF768098E9" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZM70</accession>
    <name>A0A3S0ZM70_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_014049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000526">
        <property type="protein sequence ID" value="RUS78190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZM70"/>
    <dbReference type="OrthoDB" id="10650866at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018654180" evidence="2">
        <location>
            <begin position="17"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS78190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="217" mass="22706" checksum="D0C2CF40B322C1DE" modified="2019-04-10" version="1" fragment="single">MQPLVLLPILVSMASANSIMNNILLNVLTQGMDPISRSFMKSTLGTELFDMDPSSGGSGGGVPYGMEGLVNGISNQIAQSMFKPPQWGPNSGYNPSTPTFATTNIVTPSANKPPPTNKGANFVNPYNSAPFAVSPRSSSRNVMSPAAPLPIGPTPPSVTSLANPTPTPGPSGPAQISFSSGTNGLVAPNSGMSTAPTRRANFFETFMMMRMMQMMDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZNL5</accession>
    <name>A0A3S0ZNL5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_008992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000252">
        <property type="protein sequence ID" value="RUS83228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZNL5"/>
    <dbReference type="OrthoDB" id="10585575at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS83228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="233" mass="24786" checksum="FEF151C9372827ED" modified="2019-04-10" version="1">MAKFAAYMVGSKDGAAACHQLGVNEAGILALGTLQFDAQVFLTSLQAEETDLCTVQSNVMNSPAEWASPEDITTPVVPKTRIATTLALKEEVATPATEPSNGILTMAVSVGRRKRASGELNSTIDNSTITSADVTEELPVCDFIGANMTSASEEFQEMLESISKFIRVESQNTSQSRRKKESAQDNRVSSVSVGVFSCSIIFVALGLIVLMDVSSLVAALHNFLSSGAQMQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZNQ3</accession>
    <name>A0A3S0ZNQ3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial inner membrane protease subunit</fullName>
            <ecNumber evidence="12">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_010096</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterodimer of 2 subunits, IMMPL1 and IMMPL2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S26 family. IMP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="12"/>
    <dbReference type="EMBL" id="RQTK01000301">
        <property type="protein sequence ID" value="RUS82122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZNQ3"/>
    <dbReference type="STRING" id="188477.A0A3S0ZNQ3"/>
    <dbReference type="OrthoDB" id="9996127at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.109.10:FF:000005">
        <property type="entry name" value="Mitochondrial inner membrane protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037730">
        <property type="entry name" value="IMP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041:SF2">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 12" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Peptidase S26" evidence="13">
        <location>
            <begin position="5"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S26" evidence="13">
        <location>
            <begin position="98"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS82122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="176" mass="19750" checksum="848083AFE3714858" modified="2019-04-10" version="1">MSWLRKIIKGTLIALPSYVAFTDIFYAVRTVDGLSMQPTLNPDGNNTDFVLLDRWAAASHRFERGEIVSLVSPKNPSEWLIKRVVALEGDQVKAAGCFEESVDIPRGHCWVEGDNRLCSLDSNNFGPIPTGLITAKATRVLWPPARWGPLEKKHVGVDRVTERENVSRGRVFFGWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZNY1</accession>
    <name>A0A3S0ZNY1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_008730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000241">
        <property type="protein sequence ID" value="RUS83480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZNY1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS83480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="35043" checksum="E52024A341CE010D" modified="2019-04-10" version="1">MRVWLIKKMRPLIGFESLLCVAGTLANLWFLWSILSSSRLRRSMRNQLLCNLMIAHLVQTLIVSPVEIAEYIHIINPPWDFDVYCRLEAMENIVGHIHSALTDWIIVFLVGLYCANRLNLNLAAKVGPRLGTMCQVAIHTIPWIIVVTATSVTFSKFVGLGRCQYVPSYQKFLLETFYTIIPSILSVLMLLALCVMVRRQSDIAHTDMRRQADLALSSDRMVAYVAIVGITWVCEIANITTTLQKQIDKVGTGYWMECMINLISGYRALLGLLPLLFLPDILDRVKTWRPWQPQIEPARIDLPATLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZPM0</accession>
    <name>A0A3S0ZPM0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thyroglobulin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_019928</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001083">
        <property type="protein sequence ID" value="RUS72305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZPM0"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48209">
        <property type="entry name" value="AGL056WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48209:SF2">
        <property type="entry name" value="FI24008P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018558998" description="Thyroglobulin type-1 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS72305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="24173" checksum="51C4A7EA15AFB7BB" modified="2019-04-10" version="1">MKLLLLACLLVALFADAMAYPSCLQKGLNDENCYNKNKVSVQYGPFRKTYCCDGTLMPLVKDYPYGDGTRKKCYCRLRGVPKLRDLLITLAKGSKSSKHDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDEDDNDEDDDNDDVVGISSISLIIDVQSEINIRELLKSAERNLTGAPFLGRKYDHIQLGNDSQYGHLELKNRVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZQ81</accession>
    <name>A0A3S0ZQ81_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_012010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000403">
        <property type="protein sequence ID" value="RUS80245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZQ81"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14388:SF22">
        <property type="entry name" value="SH2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14388">
        <property type="entry name" value="T CELL-SPECIFIC ADAPTER PROTEIN TSAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="4">
        <location>
            <begin position="195"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="310"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="56"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="335"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS80245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="397" mass="45587" checksum="CD3B6B03310E3463" modified="2019-04-10" version="1" fragment="single">SHIDAIVFLENKNHPFVKTYVLYYYVLFLNEANTQDIVCLIYSHQKYSVVRGFLARREFARRLKKAREEKEALEEMLRQAARLSAESADRTKKLAVSESQVKRELPPILSPDPASLAAKGSYLVPQTKKVTTGTQMDPGSDSDDLLEDDFEAAATKSSHSQRFGKEGNKQAAMNWFKETQTYNVVDQNQNRFAEWFHGIISRRESENLLKDKILGCFLIRVSESRFGYTLSFKAENRCRHYMIDQLKNEKFIIIGEPKVHRSLHNLIAYHRKTKLSNWDHLLTVPCGQVSGECDYQELVREDVYHLLEGVDSTPEVPPRNYSVKTPEPTTLQIRKPSETESKSRQEAMAETQARKSRPLPKLPEEAYQQLISDSQYKGHTYIDLQAPETPGKPKSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZRC1</accession>
    <name>A0A3S0ZRC1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_008209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000220">
        <property type="protein sequence ID" value="RUS84031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZRC1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS84031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="133" mass="15621" checksum="9B717FA6EB82BBB7" modified="2019-04-10" version="1">MMAMGWTPVVGWGDRLDSDPAILCLFKLCVVLQSVLAKDGGIVTLLNNLVNVKVGRSEREREREREREREREREEEREKIEHYWHVFFRQKDSEMRTENALIWTEKLSQPVCKAKLFTFSEILCLCVCDCVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZRT1</accession>
    <name>A0A3S0ZRT1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_018457</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000901">
        <property type="protein sequence ID" value="RUS73777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZRT1"/>
    <dbReference type="STRING" id="188477.A0A3S0ZRT1"/>
    <dbReference type="OrthoDB" id="6162222at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026:SF118">
        <property type="entry name" value="DE-CADHERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026">
        <property type="entry name" value="FAT ATYPICAL CADHERIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="5">
        <location>
            <begin position="2"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="5">
        <location>
            <begin position="112"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="5">
        <location>
            <begin position="205"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS73777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="355" mass="38883" checksum="7BBEBD88965CB282" modified="2019-04-10" version="1" fragment="single">NVTKVAATDKDGTAPNNRIMFTLDQASQELFTIDSNTGLIKTWAGLDYEMQPSHLIEVIVTDLGSPTNLNSCHVKVHVSDVNDVPPKFNKVSIHFYNFSLTLTLIGLVCWYLYAKDKDSPGSNNSKIVYSLEAANSILLDHLRIHEETGEVTISKPFDYEALVQDSSEHFQFSVLATDMGTPAQSAIINVSLIVADVNDESPEFTKASYSLSIPEDTKNGGCNNYINFSYLYADEAGTDNSRVSYSISRVISASVTEDSFQLNKTTGELQVTSPLDFESLVSSYGEFLVEVVASDSGNPPLRSMANITVRVLDENDETPQFLNDTYTASVPENSPEGKNTLILSSFSRSINSGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZWD9</accession>
    <name>A0A3S0ZWD9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_007616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000199">
        <property type="protein sequence ID" value="RUS84644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZWD9"/>
    <dbReference type="OrthoDB" id="9210134at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="1">
        <location>
            <begin position="74"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS84644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="191" mass="22384" checksum="23CA1B6EC0328BDA" modified="2019-04-10" version="1" fragment="single">KELDHSINVENRTLALSIKNRTLALSINNMTLALSIKNRTLALSIKNRTLALSIYKEQNLSIKYKEQDLSIKYKKQDFSIKYKEQDLSIKYKKQDFSINIKNRTLALSIKNRTLALSIKNRTLALSIKNRTLALSIKNRTLALSIYKEQDLSIKYKEQDLSIKYKKQDFSIKYQKLDLSIKYKKQDLSIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZZC6</accession>
    <name>A0A3S0ZZC6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_013323</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000482">
        <property type="protein sequence ID" value="RUS78910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZZC6"/>
    <dbReference type="OrthoDB" id="10570630at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018531336" evidence="3">
        <location>
            <begin position="26"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="597"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="654"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS78910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="695" mass="75809" checksum="749CF672072CB6D2" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A0B7</accession>
    <name>A0A3S1A0B7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_012777</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000449">
        <property type="protein sequence ID" value="RUS79473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A0B7"/>
    <dbReference type="OrthoDB" id="10584444at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS79473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="409" mass="42932" checksum="EA333D4EE4F76FAD" modified="2019-04-10" version="1" fragment="single">MGLLTAITSTAAASLSTRTTITKAKARPKESTTTADSIPPPQPPTRATTAKTRTTDPTPRTASSTKTIITTTASPASTATTTTTTTTASPASTATTTTATTTPPRQKSLIMLMLCLLVPTSQGVPPPPPPAVPNLEPYSSTTSASTTTVGPGGGWEEPEIRLGEFFYISFPDPVAEQFIACLCDAASQSCSVQYKLRENQTSTDFPFRYRVLSLRQARLPANDSRPAPQDPSPNPYLPYFVCDVLNFVPGEDIACVRQRASDDACGATGKCQSYSANFTLAGCGFECSQLAWLSAFTVPITYSGFEHLVSVSPNTTCLHSDGDDGGGDGGGDDNDGVTTLGLAVGLASVALVAGLVALTACLMCRRRQRLGKPDDSSKSKPPKPNSDLDPHSNGSHNRGFQEGQSHDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A987</accession>
    <name>A0A3S1A987_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_006310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000156">
        <property type="protein sequence ID" value="RUS85907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A987"/>
    <dbReference type="STRING" id="188477.A0A3S1A987"/>
    <dbReference type="OrthoDB" id="1926212at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45153">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45153:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="308"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="538"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="718"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="718"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS85907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="837" mass="93629" checksum="7AD1F78E6EF3CF42" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AD98</accession>
    <name>A0A3S1AD98_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_003285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000070">
        <property type="protein sequence ID" value="RUS88949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AD98"/>
    <dbReference type="OrthoDB" id="10678491at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS88949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="558" mass="64174" checksum="08DE9F6ABCC81B71" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1ADX5</accession>
    <name>A0A3S1ADX5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_002828</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Odd C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000057">
        <property type="protein sequence ID" value="RUS89391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1ADX5"/>
    <dbReference type="STRING" id="188477.A0A3S1ADX5"/>
    <dbReference type="OrthoDB" id="9451254at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000254">
        <property type="entry name" value="Odd-skipped related transciption factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000090">
        <property type="entry name" value="Odd-skipped-related transciption factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000311">
        <property type="entry name" value="protein odd-skipped-related 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050717">
        <property type="entry name" value="C2H2-ZF_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196">
        <property type="entry name" value="ODD-SKIPPED - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196:SF0">
        <property type="entry name" value="PROTEIN BOWEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS89391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="171" mass="19755" checksum="F07D101A12B01132" modified="2019-04-10" version="1" fragment="single">ATPTSGAAADRVKVRRPRRPKKEFICRFCHRHFSKSYNLLIHERTHTDERPYPCDICGKAFRRQDHLRDHKYIHSKEKPFKCGVCGKGFCQSRTLAVHRATHGSDHTRPFMTAKHTTRIHKDRQNMLIKAEPLPVLPLDFSRPRLAQDEVISGSKPVAEVTLTRPLPSEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AVJ5</accession>
    <name>A0A3S1AVJ5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_023754</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01002601">
        <property type="protein sequence ID" value="RUS68484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AVJ5"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018578837" evidence="2">
        <location>
            <begin position="20"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS68484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="106" mass="11421" checksum="FEBDDDAF7D781BED" modified="2019-04-10" version="1">MWKIAVLLLVAVALVSVECDRSRGPKGKGRKGPHGPPGPRPSGPPGPPGPRPSGPPGPRPSGPPRPRPQDHQDLQDHQDLQDLVQNRDSLDRLMVGFTSRKPTQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AW87</accession>
    <name>A0A3S1AW87_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_018356</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000890">
        <property type="protein sequence ID" value="RUS73886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AW87"/>
    <dbReference type="STRING" id="188477.A0A3S1AW87"/>
    <dbReference type="OrthoDB" id="6044159at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF0">
        <property type="entry name" value="XAA-ARG DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS73886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="306" mass="33405" checksum="0B4873DFED5A85AA" modified="2019-04-10" version="1" fragment="single">TVIGCPNQEGGGLIPLFRLRAFKGLDIVLAATPGPRTEWHPVYMGCQNYQALYFGSNGDPDKQKPPCNAMDASMIAYSKVLAMQEHFGRAWKAAASIVQPGSIWVERQMCQTIVKLTAPDSAGLKFLGIRVLPCLQTAAAVTGCEVMITQGEYTMHNLISNVQLGYLLQLNAYQCGVLATPRKSPRAIPPVDVAEVSRVFPTIRPMFYIGTDAMPGTAEFRDASKAPGAHNYALNMAKALAMTAVDVLHTPGTLAKVKDELKVTLEEESRFMFQPFPTNEPPKNMIYSLVTTDTPSDIGPVGWNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AYV7</accession>
    <name>A0A3S1AYV7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small acidic protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_016553</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000719">
        <property type="protein sequence ID" value="RUS75687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AYV7"/>
    <dbReference type="STRING" id="188477.A0A3S1AYV7"/>
    <dbReference type="OrthoDB" id="10066125at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026714">
        <property type="entry name" value="SMAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028124">
        <property type="entry name" value="SMAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22175:SF0">
        <property type="entry name" value="SMALL ACIDIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22175">
        <property type="entry name" value="SMALL ACIDIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15477">
        <property type="entry name" value="SMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small acidic protein-like" evidence="4">
        <location>
            <begin position="28"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="67"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="118"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS75687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="188" mass="20877" checksum="6B6EED962DADA81C" modified="2019-04-10" version="1">MSLPTSENSTDKKEKTQEDEKVHSANSWETADLGDKQRNEKFLRLMGASKKEHHGKIVIGEKATAHCRDKKAEAHLQEELEEQFSQGMEHRLAGGRKGHLGLGFHPEDKGDGVGNKDGGPDSADKSTEEKTAASSDSHTEKKTTPASEEPQKDTSDDHSREKDERKRESSDKDGEHDIKKLKFVKSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B2M4</accession>
    <name>A0A3S1B2M4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_021830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001417">
        <property type="protein sequence ID" value="RUS70402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B2M4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS70402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="294" mass="32004" checksum="ADDC7AC354DB0B11" modified="2019-04-10" version="1" fragment="single">ISLGLEGRICRISLGLEGRICRISLGLEGRICRISLGLEGRICRISLGLEGRICRISLGLEGRICRISLGLEGRICRISLGLEGRICRISLGLEGRICRISLGLEGRICRISLGLEGRICRISLGLEGRICRISLGLEGRICRISLGLEGRICRISLGLEGRICRISLGLEGRICRISLGLEGRICRISLGLEGRICRISLGLEGRICRISLGLEGRICRISLGLEGRICRISLGLEGRICRISLGLEGRICRISLGLEGRICRISLGLEGRICRISLGLEGRICRISLGLEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B321</accession>
    <name>A0A3S1B321_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_013537</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12 13">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="RQTK01000494">
        <property type="protein sequence ID" value="RUS78716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B321"/>
    <dbReference type="STRING" id="188477.A0A3S1B321"/>
    <dbReference type="OrthoDB" id="2248014at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF888">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018591791" description="ubiquitinyl hydrolase 1" evidence="8">
        <location>
            <begin position="26"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="1"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS78716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="328" mass="35671" checksum="526A4BEC8B761B73" modified="2019-04-10" version="1">MSTRTGLVSTCLNFIIIILLHQAPQNEYQDGSHAHTRSGGLLPVLPLREVDGPTRGLLTSQLQCLTCGHRSPVKYDAFDSLSLSIPTAYWGPLSVGGLLQQFIRPEVVQGVECTGCAKLAGKQTVKSNFRKKVSLGKLPQVLCVHLPRTQWLDNGAVVKRFDHVSFPEMLSMDPYVYSHTGGAGDSNRTRLMGGSDMALPTIRWVLPADPPRAQSGTGLFLTARGSPQIPRELSDINHNAPPEVPAKLGQAEFSYRLASVVCHLGDVSLGHFVTYRRGVHDGGAGLGGAASLSPRWWFASDSAVRRVSSHQVFSAEAYMLFYERVAHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B3K2</accession>
    <name>A0A3S1B3K2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Purple acid phosphatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_016978</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000757">
        <property type="protein sequence ID" value="RUS75263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B3K2"/>
    <dbReference type="STRING" id="188477.A0A3S1B3K2"/>
    <dbReference type="OrthoDB" id="45007at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="PAPs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45867:SF3">
        <property type="entry name" value="ACID PHOSPHATASE TYPE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45867">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="Purple acid phosphatase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS75263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="143" mass="16234" checksum="35345EDB564D903F" modified="2019-04-10" version="1" fragment="single">MIIVWNTVNDTKESKVLYGVKGNLNQTASGSRTVFVDGGSEQRVQFVHRVILKGLNPLTEYYYMVGSNLGFSDLFTFKTWPSGEKWSPRIVMYGDMGNENAQSLPRLQVEAVQGMYDAVIHVGRFIVLFFFCKLPVFNIILIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B4M9</accession>
    <name>A0A3S1B4M9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small monomeric GTPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_016287</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000698">
        <property type="protein sequence ID" value="RUS75941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B4M9"/>
    <dbReference type="STRING" id="188477.A0A3S1B4M9"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS75941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="14385" checksum="7F5ABC4874E95B39" modified="2019-04-10" version="1" fragment="single">MSSFNSGVFSSMFKSQNNSALAPAIIPRNAKLTKQKIVLVGSGLVGKTSIVSSYVDKFTPDVPFVLEERTRRVQVDGLYYEQTIVDTHGQEEGYRTRVGCYAGTDVFLLCFSVVSPTSFVDVREKWYPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B7I3</accession>
    <name>A0A3S1B7I3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_014402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000547">
        <property type="protein sequence ID" value="RUS77850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B7I3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS77850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="255" mass="27582" checksum="E2899AE19B901CAF" modified="2019-04-10" version="1" fragment="single">MKTKVERIAKNSASNMSKRRGAPSDQEFSTSATASPVMKRKTSKKQAEQEISPKGCTSLKHDNVNGAIGKQLVRQQKNNAGNILPVAKTKENKDSRALGKQRVNSPSPVGKDKKCVTSPSSTEKPASQARKRLSPESNLSQSTQPKVQKLQTDEKRKEDENKKKSVRSNKNAKALQSKVRGENNAKDLKSSKKSVKGKSQPSDKTASHSKAVDASDPMAMLMMMEGSVENLSEKSGSNFISSSLSPSPSLTKPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B8A1</accession>
    <name>A0A3S1B8A1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_013859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000513">
        <property type="protein sequence ID" value="RUS78388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B8A1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS78388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="235" mass="25463" checksum="9A911C603A16B32D" modified="2019-04-10" version="1">MLLERKQDPTCNLLNAVGKKTGSYLQSAQCCWKENRILPAICSMLLERKQDPTCNLLNAVGKKTGSYLQSAQCWGDGGDGDYDDDDDGDGGDDDDDDDEDEHDDDDDDDDDDDDDEDDDDEDDDDADDDDDDDDDDDDDDDDDDDDDDENDDDDKIAADDESSQSNQPDGHSTWQSPSTPSPRQLGTVRPSHRRCHASRAPHHPPPGGTALGRTEGRLGGGGEKGGGGVIIKVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BD49</accession>
    <name>A0A3S1BD49_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Anaphase-promoting complex subunit 4-like WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_011064</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000351">
        <property type="protein sequence ID" value="RUS81199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BD49"/>
    <dbReference type="STRING" id="188477.A0A3S1BD49"/>
    <dbReference type="OrthoDB" id="239701at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="828"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="5">
        <location>
            <begin position="984"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1158"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="87"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="697"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1124"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="703"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS81199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1192" mass="130456" checksum="7BBDDB370797CEDA" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BDE4</accession>
    <name>A0A3S1BDE4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_014092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000530">
        <property type="protein sequence ID" value="RUS78144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BDE4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS78144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="174" mass="18651" checksum="B9A173A1A38DEFC9" modified="2019-04-10" version="1">MSHLVDPNSTQQARVHWSPSTSSTPNAPPYKPRLSATKESSVDVEDHVKPASSLQRRSSKGSNTSSTRSFRSNTGSAGRPSPKKLPIPHVVIWTAKHGSRTSATASLSTSGSSRSSLAAAFVFPELMGSNIVPGMDLSHLSPTITEQPRKSDWSLGSDTEEDVTPRKRNCCCCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BIN4</accession>
    <name>A0A3S1BIN4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
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        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
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            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
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        </lineage>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="RUS81662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="692"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="778"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="810"/>
            <end position="876"/>
        </location>
    </feature>
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            <begin position="915"/>
            <end position="934"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
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            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="97"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="165"/>
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            <end position="229"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
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    <sequence length="1065" mass="119828" checksum="909BCCB1FA96FFF2" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
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        <name type="common">Eastern emerald elysia</name>
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    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000188">
        <property type="protein sequence ID" value="RUS84927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000271974">
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="RBD_domain_sf"/>
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        <property type="entry name" value="RRM_dom"/>
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    <dbReference type="PANTHER" id="PTHR48032:SF6">
        <property type="entry name" value="RNA-BINDING (RRM_RBD_RNP MOTIFS) FAMILY PROTEIN"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="103" mass="11527" checksum="B5827633F7A7D309" modified="2019-04-10" version="1" fragment="single">MEQALVPVTNGSIEEDHDPGKMFVGGLSWQTTGDTLREYFNKFGEIKEAQVMKDPTTRRSRGFGFVTFMDPDSITKVMDTKPHQIDSKGVDPKVAVPKKLNPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BJT5</accession>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="RUS85470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <proteinExistence type="predicted"/>
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        </location>
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        </location>
    </feature>
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        </location>
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        </location>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="RUS85470.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="662" mass="70822" checksum="3E15F4711DF65E63" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BLH3</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="common">Eastern emerald elysia</name>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
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                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000139">
        <property type="protein sequence ID" value="RUS86417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BLH3"/>
    <dbReference type="OrthoDB" id="10662850at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS86417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="156" mass="17168" checksum="59F5D8A9187630A3" modified="2019-04-10" version="1" fragment="single">SPSPTSAPNSGLDTGLQDHPEGEGQEDQEDQEKAQNVPDYLASSEQNEVRQTTPRPPLDGEETERVGAGRQEEEDTPKMDDIIQDLEEKERNAEMPQEQEGYTEDSREDSGQFGGDEEVEETRGRQPAPPQTYRAPGGRGRAGRDPSPGKPVRPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BMF4</accession>
    <name>A0A3S1BMF4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_021772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001403">
        <property type="protein sequence ID" value="RUS70464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BMF4"/>
    <dbReference type="OrthoDB" id="10661916at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="639"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="695"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS70464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="721" mass="76860" checksum="DCA6AF18F54FB3AE" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2022-12-14" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BPB2</accession>
    <name>A0A3S1BPB2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_003897</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000086">
        <property type="protein sequence ID" value="RUS88326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BPB2"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS88326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="100" mass="12677" checksum="D955944CB786A8BF" modified="2019-04-10" version="1">MFFSLFSRSLYAEYKYFITLIEYEKRCIMRAVCSAVASGCLRMHWRLDERKKEREREREREREREWRREAYKRQRKIKSYSYFKLSQTLLTHRKIYTVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BPV9</accession>
    <name>A0A3S1BPV9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proline dehydrogenase</fullName>
            <ecNumber evidence="8">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_006365</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>trans-4-hydroxy-L-proline + a quinone = (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52512"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:58375"/>
            <dbReference type="ChEBI" id="CHEBI:62612"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the proline oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="8"/>
    <dbReference type="EMBL" id="RQTK01000157">
        <property type="protein sequence ID" value="RUS85881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BPV9"/>
    <dbReference type="STRING" id="188477.A0A3S1BPV9"/>
    <dbReference type="OrthoDB" id="5464at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914:SF29">
        <property type="entry name" value="HYDROXYPROLINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 8" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proline dehydrogenase" evidence="10">
        <location>
            <begin position="265"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS85881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="521" mass="58258" checksum="2EF56DD8F0FD365F" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BQD9</accession>
    <name>A0A3S1BQD9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_006011</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000146">
        <property type="protein sequence ID" value="RUS86216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BQD9"/>
    <dbReference type="STRING" id="188477.A0A3S1BQD9"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="49"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="512"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="547"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="574"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="592"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS86216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="601" mass="66513" checksum="67FBDC7E953B8BDA" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BR90</accession>
    <name>A0A3S1BR90_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_005508</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the Sp1 C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000130">
        <property type="protein sequence ID" value="RUS86718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BR90"/>
    <dbReference type="STRING" id="188477.A0A3S1BR90"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000014">
        <property type="entry name" value="Transcription factor Sp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000026">
        <property type="entry name" value="Transcription factor Sp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF170">
        <property type="entry name" value="FI01014P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="666"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="696"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="726"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="43"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="607"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="772"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="607"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="617"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="774"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS86718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="816" mass="85501" checksum="E79B736E3D873401" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BRM1</accession>
    <name>A0A3S1BRM1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_002392</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000046">
        <property type="protein sequence ID" value="RUS89862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BRM1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31535">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31535:SF3">
        <property type="entry name" value="REGULATORY PROTEIN ZESTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS89862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="295" mass="31862" checksum="F7D8399646E9F91F" modified="2019-04-10" version="1">MMMVVVLVVVVVVMVVMMVVVVVVVVVVVVVVVVVVVMVVVVVGAERTTIYGTDGGGGGGGGGGGGGGGDGGGDDGGGGGGGDGGGGGGGGDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDNDLMLLLLLLMMMMMMMMMMMMMMMMMMMMARQDKKNITAQHILNSLALVRPNVPYNSLSVSIPRAWNKGFKLLRKPVEYGVYDMIRHRKFGWSNNPERYRVFTTRLKRQDIDGLNTAIYNITGVGIFPIYTWISVNFDADILIQTVPAHLRQSEPKIQNEPAMQPVTIEYLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BS56</accession>
    <name>A0A3S1BS56_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_004736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000109">
        <property type="protein sequence ID" value="RUS87482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BS56"/>
    <dbReference type="OrthoDB" id="6156863at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS87482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="32374" checksum="84F400FEDEDA43D2" modified="2019-04-10" version="1">MYYVHIKKQANTCLKKFPIPNKNLALLSTIDPELCGHSAAAKGLQDLFDLFPTIVDTSTTSKDQFSMAASVLQNDTNFTSTITDKKLDTWLANVLANPNYKLLRPVVKSFLSIFTGPRVESSFSVMNNIITSSTNRTLIETYQAIHKVKYKLLNAQKTSTQMFERKDPVHSPVDPSLCYYVQTAAKRMVTAKRNISRRIPKVPKTTVHIQTNAIRTAIEDNAIAASCSVASTSSTSTACENASPTANMSSTNTIAAVGSTSDKKLHNKRKAPEHSLKPSAKKTCGNLMAYLKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BSI9</accession>
    <name>A0A3S1BSI9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP synthase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EGW08_001746</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">EC2010</strain>
            <tissue evidence="16">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000031">
        <property type="protein sequence ID" value="RUS90478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BSI9"/>
    <dbReference type="STRING" id="188477.A0A3S1BSI9"/>
    <dbReference type="OrthoDB" id="9805536at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18116">
        <property type="entry name" value="ATP-synt_F1_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1-ATPase_alpha_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.150.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002432">
        <property type="entry name" value="ATP synthase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="entry name" value="ATP synthase alpha/beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a_nt-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009884">
        <property type="entry name" value="PRK13343.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082:SF2">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039088">
        <property type="entry name" value="F_ATPase_subunit_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="15">
        <location>
            <begin position="70"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="13">
        <location>
            <begin position="193"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase alpha subunit C-terminal" evidence="14">
        <location>
            <begin position="423"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RUS90478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="555" mass="59942" checksum="2E620132FF169FDD" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BUC0</accession>
    <name>A0A3S1BUC0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Peptidase M12B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EGW08_000361</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">EC2010</strain>
            <tissue evidence="16">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000005">
        <property type="protein sequence ID" value="RUS91790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BUC0"/>
    <dbReference type="STRING" id="188477.A0A3S1BUC0"/>
    <dbReference type="OrthoDB" id="412680at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04273">
        <property type="entry name" value="ZnMc_ADAMTS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000001">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006586">
        <property type="entry name" value="ADAM_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002870">
        <property type="entry name" value="Peptidase_M12B_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF256">
        <property type="entry name" value="PEPTIDASE M12B DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01562">
        <property type="entry name" value="Pep_M12B_propep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00608">
        <property type="entry name" value="ACR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="9 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12B" evidence="15">
        <location>
            <begin position="447"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="234"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="402"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="404"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="594"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="593"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="597"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="603"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="571"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RUS91790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="738" mass="82141" checksum="B3CE4EE55F82FEE1" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BZ73</accession>
    <name>A0A3S1BZ73_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">VWFD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_013514</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000493">
        <property type="protein sequence ID" value="RUS78727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S1BZ73"/>
    <dbReference type="OrthoDB" id="6262482at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000055">
        <property type="entry name" value="alpha-tectorin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050780">
        <property type="entry name" value="Mucin_vWF_Thrombospondin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014853">
        <property type="entry name" value="VWF/SSPO/ZAN-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339">
        <property type="entry name" value="EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339:SF386">
        <property type="entry name" value="HEMOLECTIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08742">
        <property type="entry name" value="C8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00832">
        <property type="entry name" value="C8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00215">
        <property type="entry name" value="VWC_out"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="85"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="150"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="185"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="8">
        <location>
            <begin position="271"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="8">
        <location>
            <begin position="627"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="8">
        <location>
            <begin position="1087"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="187"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS78727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1502" mass="163555" checksum="F15A727122385724" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C5I8</accession>
    <name>A0A3S1C5I8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_008658</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000239">
        <property type="protein sequence ID" value="RUS83552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C5I8"/>
    <dbReference type="STRING" id="188477.A0A3S1C5I8"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="356"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="24"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="167"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="279"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="280"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="298"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS83552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="563" mass="62612" checksum="920BEAA4072BE94A" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1CB88</accession>
    <name>A0A3S1CB88_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4590 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_004193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000094">
        <property type="protein sequence ID" value="RUS88027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1CB88"/>
    <dbReference type="STRING" id="188477.A0A3S1CB88"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048257">
        <property type="entry name" value="DUF4590"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027962">
        <property type="entry name" value="ERICH3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23034">
        <property type="entry name" value="GLUTAMATE-RICH PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23034:SF2">
        <property type="entry name" value="GLUTAMATE-RICH PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15257">
        <property type="entry name" value="DUF4590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4590" evidence="2">
        <location>
            <begin position="322"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="563"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS88027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="597" mass="65529" checksum="32C7F681E6D9D43C" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1CGE8</accession>
    <name>A0A3S1CGE8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_000330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000004">
        <property type="protein sequence ID" value="RUS91928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1CGE8"/>
    <dbReference type="STRING" id="188477.A0A3S1CGE8"/>
    <dbReference type="OrthoDB" id="5875367at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052220">
        <property type="entry name" value="METTL25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496">
        <property type="entry name" value="CGI-41 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496:SF2">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 25B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13679">
        <property type="entry name" value="Methyltransf_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="185"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS91928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="594" mass="66579" checksum="EC5A01C11A793D93" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H009</accession>
    <name>A0A3S1H009_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 19">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="13">IMP dehydrogenase</shortName>
            <shortName evidence="13">IMPD</shortName>
            <shortName evidence="13">IMPDH</shortName>
            <ecNumber evidence="13 19">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">EGW08_022712</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">EC2010</strain>
            <tissue evidence="21">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13 19">
            <text>IMP + NAD(+) + H2O = XMP + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="13">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13 19">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13 18">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="13 19"/>
    <dbReference type="EMBL" id="RQTK01001654">
        <property type="protein sequence ID" value="RUS69525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H009"/>
    <dbReference type="STRING" id="188477.A0A3S1H009"/>
    <dbReference type="OrthoDB" id="416622at2759"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04601">
        <property type="entry name" value="CBS_pair_IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000007">
        <property type="entry name" value="Chromosome 19 SCAF14664, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF111">
        <property type="entry name" value="INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 17" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13 19" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="5 13 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13 15" id="KW-0520">NAD</keyword>
    <keyword evidence="9 13 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 13 16" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 13 19" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="20">
        <location>
            <begin position="114"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="20">
        <location>
            <begin position="179"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="13 14">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13 14">
        <location>
            <position position="429"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13 15">
        <location>
            <begin position="274"/>
            <end position="276"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 15">
        <location>
            <begin position="324"/>
            <end position="326"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13 16">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13 16">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13 16">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="364"/>
            <end position="366"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="387"/>
            <end position="388"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="411"/>
            <end position="415"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="496"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RUS69525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="514" mass="55355" checksum="57B5E2F41FD9157A" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H4V4</accession>
    <name>A0A3S1H4V4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_020006</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001094">
        <property type="protein sequence ID" value="RUS72233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H4V4"/>
    <dbReference type="STRING" id="188477.A0A3S1H4V4"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="17"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS72233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="507" mass="56539" checksum="9185EDEAE678F385" modified="2019-04-10" version="1">MELLKGLNQLFSESLLCDFTIQAGEKCVDVHRCVLAACSPYFKAMLTVDMFENTKRTVLLQNVDSAVLQDLVKFMYTGYISINSSNVQSLLLAADMLQIQRLVQHCEEYMSSSLSTENCLDVLSFADFQNLISTDELIANNVFCHQLISKFVQALSSGGHDPCKEMFCSTPRLGMHSRNMIVFSGGAFSPNDRSFCCFDPVTLQSFYSIKHHPTFDFKFKLDFYRLLVTENNDIYVLGGIFYDDYHFESGGGLAKGNVLVYSEQNGKWEDCASMDVPKCAFGACCYKDKIYVFGGYTAYPGHPPLDHVSVYDASLDVWENLDSMPIGIAHQATTVFRNSAFLLGGIDAGGQYLNTIIQYHFAQDKWTLLSSEMPVPRAEASAFVNDNHIIVLGGSNNTGGITSVNIFDVDRLRWSYASDFPEERKFTSVCQGNGCLFVCGGVRLSSARPGLLRASRSVELRDLYKYDCTQDEWVKLTRIVEQGSSFTCAYASVNCKFLTEYEGATSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HXH3</accession>
    <name>A0A3S1HXH3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_004085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000092">
        <property type="protein sequence ID" value="RUS88123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HXH3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS88123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="106" mass="11250" checksum="81944991DFD982AD" modified="2019-04-10" version="1" fragment="single">MPRLTIQQDKTLQTACTKLIDLRHVRVKLAVQVRFALAHVLVQLAVQVMGCHRPSSVGGRRAPPASTPATSLTPLTPSECAAPPLAPPSSHYGLAGEPVVGEKNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1I063</accession>
    <name>A0A3S1I063_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_002644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000051">
        <property type="protein sequence ID" value="RUS89626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1I063"/>
    <dbReference type="STRING" id="188477.A0A3S1I063"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS89626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="151" mass="16998" checksum="11C8FA04F6015BB2" modified="2019-04-10" version="1" fragment="single">CVSHSHINHCVSHSHINHCVSHSHINHCVSHSHINHCVSHSHINHCVSHSHINHCVSHSHINHCVSHSHINHCVSHSHINHCVSHSHINHCVSHSHINHCVSHSHINHCVSHSHINHCVSHSHINHCVSHSHINHCVSHSHINHCVSHSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SI79</accession>
    <name>A0A433SI79_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PLAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_023696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01002394">
        <property type="protein sequence ID" value="RUS68542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SI79"/>
    <dbReference type="STRING" id="188477.A0A433SI79"/>
    <dbReference type="OrthoDB" id="5322100at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01756">
        <property type="entry name" value="PLAT_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052970">
        <property type="entry name" value="Inner_ear_hair_cell_LOXHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45901:SF3">
        <property type="entry name" value="LIPOXYGENASE HOMOLOGY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45901">
        <property type="entry name" value="PROTEIN CBG12474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00308">
        <property type="entry name" value="LH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLAT" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="2">
        <location>
            <begin position="73"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS68542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="227" mass="25566" checksum="8DFF3D904A8A0E1B" modified="2019-05-08" version="1" fragment="single">FRIGHDNKGGGGAWFLDKVVIDAPSLGRTWVFPCGHWLSDSDEDRLLERELFPQELATELINAKTFLFLLPAKTYTVEVFTGDVKGGGTDANVFINIFGDKGDSGERALRNSETNRDKFERNKMDRFKLEAVDLGSLYKVKIRHDNSLFNPAWYLDRVEILDGADKFVFHCERWLAKNKDDGKIERSLYVKGYDGDMNSSTGTLKSKFGGSVASLDSMRTSDPFSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SJF1</accession>
    <name>A0A433SJF1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_023133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001832">
        <property type="protein sequence ID" value="RUS69108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SJF1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS69108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="110" mass="11969" checksum="65983105D15292CE" modified="2019-05-08" version="1">MTVDLVFLYPCPPHALDLPELSCAPILFSERVPPICCLAARFTCKDAPPTCCIAARFTCKDAPPTCCIAARFTCKDAPPTCCITCLVIVKPIHFHYIGLTSCSAHQILEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SM70</accession>
    <name>A0A433SM70_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_021947</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001446">
        <property type="protein sequence ID" value="RUS70270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SM70"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS70270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="332" mass="37196" checksum="9FD443C34F835E7C" modified="2019-05-08" version="1">MGFGILWINPQEVISDSVLIARPSGVCNLTGRPTVGRDMSHPDESQYDKYTTQTHTAVGRMSLGTHPGIFWHNASYVKSNHTMDDKTVPFYSKTKLRNVISWLNERTGGSHETPTSTSTTADGWWPVFCPPTLPKSFFESANSPVGRLNTHYSTVEEFDHMFCNRNINDIKFPSTFTVNPVFTHPFANINSECLYPSIFLNEPGFPLTKYLTFNRTAALAAANMSNAMSKSIKDIFNERAKDNADDDNDGIINYLGMTHNNISHLTGAALPKPCWTTMDLSAGLMSREDFKDAKMYAKTSVVTNGDTGFYITGTHAQGRFERRNVSHFRYPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SQ01</accession>
    <name>A0A433SQ01_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_020924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001234">
        <property type="protein sequence ID" value="RUS71316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SQ01"/>
    <dbReference type="OrthoDB" id="10469758at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019040859" evidence="1">
        <location>
            <begin position="25"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS71316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="168" mass="17618" checksum="85D1384B875ED476" modified="2019-05-08" version="1" fragment="single">MECSNFTVVLVCFICAGLASLASSQSHGDTAAPVRCYSCDGNHSGTGSFAQCLASAPTTCSPGQGCRVSYRTDWNDLPTIGCSAVCPDMDPASKACPLGGHASSLHVCDACCKNDTCVDQITSGLMAQAPVICPNHCLGGHLDNCWDDVKLCGKDEFCELRVAHHRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SQ31</accession>
    <name>A0A433SQ31_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_020882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001228">
        <property type="protein sequence ID" value="RUS71352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SQ31"/>
    <dbReference type="OrthoDB" id="10026604at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="2"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS71352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="107" mass="12232" checksum="6CE3B348B91D749D" modified="2019-05-08" version="1" fragment="single">EWSEALASQAQASISCRSHRRGQVQLLEQFIPHVNVGRRRDRPGALATIMSGWFEQRAHYDSEEGACFPWDICKQYTNMINAKHRIMGCAYIQDCGTRNESVVLMCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SRJ0</accession>
    <name>A0A433SRJ0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_020342</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAGUK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001144">
        <property type="protein sequence ID" value="RUS71889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SRJ0"/>
    <dbReference type="STRING" id="188477.A0A433SRJ0"/>
    <dbReference type="OrthoDB" id="65789at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10832">
        <property type="entry name" value="PDZ_MPP6-MPP2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11862">
        <property type="entry name" value="SH3_MPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050716">
        <property type="entry name" value="MAGUK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23122">
        <property type="entry name" value="MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="99"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="184"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate kinase-like" evidence="5">
        <location>
            <begin position="308"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS71889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="506" mass="57555" checksum="D5DC3B587B1A2AB5" modified="2019-05-08" version="1">MPIATTESLSAKEAIDVLAEQLDDLYDIGAKTLDLDFLRAILTDESLFNVVDALLVAHDDITNKNFEGDIDNSQNITQGPQLLSPLPPVFNSTQEQVRYVNIRKSETEPLGITVKLDEMNDLQVARILQGSLVDKQGMLHVGDVIREVNGFPVATPEQLMELIIDSDPDISLKIIPSFQHFNKSEPVYMKAHFSWDPMKDRLLPCKEAGLPFNDGDILEIVSSDDTNWWQARLAEIDGPVGLVPSSALEEKRKSFVNPDLDYSKSSLFCGLTKKKKKTIKYSSKDSKEYDKADVLIYEEVRRMAPFERPFLVLVGAKGVGRRSLKNRLIKDDPRRFGTPIAHTSRAPRAKEVDGQGYYFTDRETMERDILDNKYVEHGEFNLNLYGTRVDSCWDVVKSRKMCVLDVSPAALKMLKSQEFMPFIVFVAAPSVEALKVMYEEGKHVRGGREEDFIQTVKESAKIEKVFNTYFDKIIVNDNFEDTYLELRRALSEMTAKQQWVPVNWVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SS60</accession>
    <name>A0A433SS60_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">protein O-GlcNAcase</fullName>
            <ecNumber evidence="6">3.2.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Beta-hexosaminidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_020126</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H2O = N-acetyl-D-glucosamine + L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:48876"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:12251"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:90838"/>
            <dbReference type="ChEBI" id="CHEBI:506227"/>
            <dbReference type="EC" id="3.2.1.169"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H2O = L-threonyl-[protein] + N-acetyl-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:48892"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:12252"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:90840"/>
            <dbReference type="ChEBI" id="CHEBI:506227"/>
            <dbReference type="EC" id="3.2.1.169"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.169" evidence="6"/>
    <dbReference type="EMBL" id="RQTK01001112">
        <property type="protein sequence ID" value="RUS72113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SS60"/>
    <dbReference type="STRING" id="188477.A0A433SS60"/>
    <dbReference type="OrthoDB" id="9975416at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102571">
        <property type="term" value="F:[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016231">
        <property type="term" value="F:beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000009">
        <property type="entry name" value="O-GlcNAcase BT_4395"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.240">
        <property type="entry name" value="STAT, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051822">
        <property type="entry name" value="Glycosyl_Hydrolase_84"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011496">
        <property type="entry name" value="O-GlcNAcase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13170">
        <property type="entry name" value="O-GLCNACASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13170:SF16">
        <property type="entry name" value="PROTEIN O-GLCNACASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07555">
        <property type="entry name" value="NAGidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52009">
        <property type="entry name" value="GH84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH84" evidence="9">
        <location>
            <begin position="17"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="455"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="455"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="483"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="498"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00066938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00076634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS72113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="887" mass="99400" checksum="0E9F55606F2C7116" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SSX9</accession>
    <name>A0A433SSX9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UPF3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_019865</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RENT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001075">
        <property type="protein sequence ID" value="RUS72367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SSX9"/>
    <dbReference type="STRING" id="188477.A0A433SSX9"/>
    <dbReference type="OrthoDB" id="18087at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12455">
        <property type="entry name" value="RRM_like_Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000717">
        <property type="entry name" value="regulator of nonsense transcripts 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039722">
        <property type="entry name" value="Upf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005120">
        <property type="entry name" value="UPF3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112:SF0">
        <property type="entry name" value="FI21285P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112">
        <property type="entry name" value="UPF3 REGULATOR OF NONSENSE TRANSCRIPTS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03467">
        <property type="entry name" value="Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF3" evidence="6">
        <location>
            <begin position="32"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS72367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="200" mass="22731" checksum="D7E365295A1ED320" modified="2019-05-08" version="1" fragment="single">MAQDQVAQEGDEPPSQSTAANPDRKKEKDHTPSKVVIRRLPPTLTPEEFLEQVSPLPDYDFFYFVRADMSLGPNAFSRAYVNFLAPEDIFIFRDKFDGYVFLDSKGGEYPALVEFSPFQKVPKKKPKKVDAKNGIIELDADYKKFLEFLSNPVEVAPVSLDAMVGEVEAKESSAKPGVSHMTTPLLEYLRRRREERKLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SU60</accession>
    <name>A0A433SU60_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_019421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001014">
        <property type="protein sequence ID" value="RUS72816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SU60"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS72816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="249" mass="28348" checksum="742C51B18EE03D3E" modified="2019-05-08" version="1">MASGTVLASGFLVGGYRKKKKKKKKKKKKKKKKKKKKKKKKKINTTTAKTTTTTTKQQQQKQQQSKQKEEDNEDDKDRSNIVDLAACETTDCARVCVYYVQYQIGGCIDAKGRCSIPNFTQRVRDLRDRELRPYRSAPASIPHVSSCRSIYDVTRRDGREITPRDPGVSQNPSQNPSLSHHGQGRNSRASPQPIRERHTTWACYPHPNDGFSQRGDRGYEGLCTLGLGTLDLFAERITKNTRGDWFINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SUY8</accession>
    <name>A0A433SUY8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_019141</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">May play a role in vesicular transport from endoplasmic reticulum to Golgi.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 11">Golgi apparatus</location>
            <location evidence="2 11">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000977">
        <property type="protein sequence ID" value="RUS73097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SUY8"/>
    <dbReference type="STRING" id="188477.A0A433SUY8"/>
    <dbReference type="OrthoDB" id="10262857at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14942">
        <property type="entry name" value="TRAPPC3_bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000003">
        <property type="entry name" value="Trafficking protein particle complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016721">
        <property type="entry name" value="Bet3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13048">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018293">
        <property type="entry name" value="TRAPP_I_complex_Bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR018293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS73097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="180" mass="20189" checksum="E7AB1957C68BB5CC" modified="2019-05-08" version="1">MSRQANRAGDPRKVNGELFTLTYGALVAQLIKDYENDEQVNKQLDKMGYNMGVRLIEDFLARANTGRCNDFRETADVIAKVAFKLYLGLTPVVSNWSTTGDEFSLLLESNPLTEFVELPPGHSNLNYSNLLCGALRGALEMVQMDVDVRFVQDILKGDNITEIRLKFIKRLEDAVPVGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SV28</accession>
    <name>A0A433SV28_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_019102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000973">
        <property type="protein sequence ID" value="RUS73140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SV28"/>
    <dbReference type="OrthoDB" id="10633873at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="321"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="208"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="330"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="359"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS73140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="398" mass="43131" checksum="E3A37B656708C45E" modified="2019-05-08" version="1">MNRRFNNSEDHLGQHLSKSTLRSLAADQSNNMQQVLYADEGTSLPPVKVRGRVRALGRTIKERGEVCQWIQSMTLEPPVPRNKTSLHPANSEASDASRAFPKMAGAKTAGESDLTANATAAENHHPLQSGGAGAPVTAARALLGLDGPIVGSRDLSKRADADEEPSFAEQLSMIRQQQSVLLEKQRVIQEQMSMSAGGSDASLPVDRKSEADLQMEKRAQEKEALEKQLQLVNARNNSGIETKHRRLKGTLANHYAQRDEGTVGSLLWTISDEDAPKNDLSLTNSLCCMSSSAQRQQYSNHRHDTSSSISDLLRETSFLNSRSRHGYGSSDASLGDRQSTPQPKSVENNRKCDVKPTGRGSNSGCPSDQAGESQTNCSCFGEGDLQDDQCTISIASAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SW65</accession>
    <name>A0A433SW65_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_018715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000927">
        <property type="protein sequence ID" value="RUS73530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SW65"/>
    <dbReference type="STRING" id="188477.A0A433SW65"/>
    <dbReference type="OrthoDB" id="5800121at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF28">
        <property type="entry name" value="ENDONUCLEASE-REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS73530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="373" mass="42363" checksum="9AAFBA59F054CE5A" modified="2019-05-08" version="1">MAFVDLEKAFDRVPRKVIWWALRKLGVEEWTVRLVQGMYANARSQVRVGDGYSEEFEVKVGVYQGSVLTPLLFIVVLEALSREFRSGVPWEDLYADDLVIIAESQLRRVPLCCKKWVHKKCSGLKRLTKDSDYKCSRCQGTARPIDGRPQSEVQVGSDKLDVVASFCYLGDMLSAAGGCDLATTTRVKTAWKKFKELLPVLLSRHLSYKTRGHVYSTCVRSAMLHASETWPLTKPNLQRLQRNDRAMIRQICNVKPKDVATTRSNELLTLLGLEDLNLILKERRLRWYGHVERSSGAIKTALDMQVTGSRGKGRPRMTWKQVTERDRKDWKLSTTDPHDRNTWRSGVRSAMRAASQLPGRGSTDVDVAPVPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SY02</accession>
    <name>A0A433SY02_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4371 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_018199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000872">
        <property type="protein sequence ID" value="RUS74050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SY02"/>
    <dbReference type="OrthoDB" id="6116262at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601:SF1">
        <property type="entry name" value="ADF-H DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601">
        <property type="entry name" value="ULP_PROTEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS74050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="644" mass="72964" checksum="5083AB9E9D883C59" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SYV6</accession>
    <name>A0A433SYV6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_017760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000827">
        <property type="protein sequence ID" value="RUS74485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SYV6"/>
    <dbReference type="OrthoDB" id="6062348at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="878"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="941"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="941"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="979"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="993"/>
            <end position="1003"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS74485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1003" mass="112266" checksum="7BF64E03FC50E2B1" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SYX1</accession>
    <name>A0A433SYX1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_017720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000824">
        <property type="protein sequence ID" value="RUS74513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SYX1"/>
    <dbReference type="STRING" id="188477.A0A433SYX1"/>
    <dbReference type="OrthoDB" id="6158733at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS74513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="181" mass="20128" checksum="6D2F2C16B9F62B0C" modified="2019-05-08" version="1" fragment="single">MSMCPNHNNFTGSLVLDCRGQNAIIALGVYLLESGLQHKDVIIKYLLMILEKMPNSDWADGPRGINKFNLPTAECFSFCLNTILCDVAFRLPEYKDKIIFAQLNVLDNMTSLCEQASGHVTVYATTAKSRKKLCLRQIPLLLGLARSMGRSSDEDLSLISYLLTVHEIPPTSEAASLGQRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T206</accession>
    <name>A0A433T206_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_016687</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000730">
        <property type="protein sequence ID" value="RUS75562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T206"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS75562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="186" mass="21018" checksum="D3923A216F0B06E5" modified="2019-05-08" version="1" fragment="single">MMGSEGRHIHASFSRWHLCDRCRFLVLLLLLLILFLLLPLLLIPPPPLLLLLLLIIPLPLPPPHPPPLLLFLLLSLLLLLPSPPLILLLRGGGGGGGGRRRRGRRRRRKRRGGGGRRRRGRRRRKRRRGGGGGGGRGRGRRRRRKRRGGGGRRRRGRRRKRRRGGGGGGGRGRGRGRRRRRRRGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T2J3</accession>
    <name>A0A433T2J3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_016470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000713">
        <property type="protein sequence ID" value="RUS75765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T2J3"/>
    <dbReference type="OrthoDB" id="6085335at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS75765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="288" mass="32117" checksum="7F1034A6D361BA77" modified="2019-05-08" version="1" fragment="single">AYWESSINSTWYRLEPTDFSKYREFLVIYFGYLNTIFKVLIPIACVSVCNTVLVCCLRRRRSLFAQHVQLCQYSDVQSPATQLSTAGPTANGSPCHSRENSRENSCEKRPDGCASDCSLKLSPIYRRGDTCNGHSNRDSCDSDFDLSASPCNKHSPGSIAAKFGSAREREQSSSFIRLGGKQYPGNKLSASPTSQHHHHHHHHHHQHQQQHKKKQHRKRTAGAGRSGDAKVTSMVLAVTWTFLISQAFAGAQVILHLTGSQATCGQRCVLFNQFCDLVYVLVSATNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T2P7</accession>
    <name>A0A433T2P7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_016419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000709">
        <property type="protein sequence ID" value="RUS75827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T2P7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS75827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="126" mass="13694" checksum="474A78D5D6796DCA" modified="2019-05-08" version="1">MPPSYEECVFGRMESQELEPGEVGVEDDDDHTRGGTAAGTSNTASRRPRLHRLPSYPYYSFESPSPSTSTTPAPPSSVRPDHSYPDAPPPLPSGENQGYHLLPVSEQPTYTSLPPPPSYESLGLNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T348</accession>
    <name>A0A433T348_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_016234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000694">
        <property type="protein sequence ID" value="RUS75989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T348"/>
    <dbReference type="STRING" id="188477.A0A433T348"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS75989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="154" mass="18971" checksum="0B56EE05FAB03C76" modified="2019-05-08" version="1" fragment="single">AIHTTRYRVTDWTQAIHTTRYRVTDWTQAIHTTRYRVTDWTQAIHTTRYRVTDWTQAIHTTRYRVTDWTQAIHTTRYRVTDWTQAIHTTRYRVTDWTQAIHTTRYRVTDWTQAIHTTRYRVTDWTQPIHTTRYRVTDWTQAIHTTRYTPQDTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T4G4</accession>
    <name>A0A433T4G4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_015757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000659">
        <property type="protein sequence ID" value="RUS76473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T4G4"/>
    <dbReference type="OrthoDB" id="6158622at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS76473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="25516" checksum="8E779DDE9C6C5F6F" modified="2019-05-08" version="1">MLKKCCKGDGHSRQPGFLQLSVLCAAFFANEITVTFELIYMVSVERLLSLPLQFVSLPGVVASASSFVIVPLMGRYTDSGNRHRRRSAMVVLSGALQFTGALLLLTACAKFIHIQTQSLEVNSKQNHGLLSEASKMEKEVNEFSFSKVFGGNVNETSTQFESDVPFNWTIPPNRNNDEDIEGESHSISSALTACLALVSFSVMAVGFDIGTSSIRAFVLDCVPPEAHSNVLSVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T4P4</accession>
    <name>A0A433T4P4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_015766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000659">
        <property type="protein sequence ID" value="RUS76482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T4P4"/>
    <dbReference type="STRING" id="188477.A0A433T4P4"/>
    <dbReference type="OrthoDB" id="304163at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="67"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS76482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="295" mass="34811" checksum="4C23F082B60698B1" modified="2019-05-08" version="1" fragment="single">QELREREKNSQRLVENLQEKACKLHEQLQQRESALILCRNEVKSHLAAMDEVKASFQCELQQREMVIKQMKDDLQRIYDDLRQKSEENSQLERAVMDYKARVHQYCCQVKEAESRIACLQDKMQQMECQHGKEKQQCMHDMEEFEKKLNACCNDLCNSQNDLRRMNRCLAEKDEEVQNLNSERSCLARDLQIEKESTCAQMERALSLENDNKEICRLLQQKVKCIKELENALCEKQQELFQCQNCIDELNAKIRELNVGTVGGDDNTDLESQLRDCRAKMTKLQTELEDTKHRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T7E5</accession>
    <name>A0A433T7E5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_014766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000578">
        <property type="protein sequence ID" value="RUS77460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T7E5"/>
    <dbReference type="STRING" id="188477.A0A433T7E5"/>
    <dbReference type="OrthoDB" id="10236140at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.50">
        <property type="entry name" value="Insect antifreeze protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053359">
        <property type="entry name" value="CRAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35577:SF7">
        <property type="entry name" value="CYSTEINE-RICH, ACIDIC INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35577">
        <property type="entry name" value="CYSTEINE-RICH, ACIDIC INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS77460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="283" mass="32495" checksum="0FFC96C933D329CD" modified="2019-05-08" version="1" fragment="single">PRRSPCPRHSPFSRYSPCPRHSPCSRYGPCPRHSPCPRHKSCPRHSPCSRHSPCPRYSPCPRYSPCSRYGPCPRHSPCPRHSPCPRHSPCSRHSPCPRYSPCPRYSPCSRYGPCPRHSPCSRHKSCPRHSPCPRYSPCPRHSPCSRHSPCSRYSPCSRHKSCPRHSPCSRHSPCSRHSPCSRHKSCPRHSPCSRHSPCSRWMRIRSMPKTQSCPRHSPCPRHKSCPRHSPCSRYGPCPRHSPCPRHSPCSRYSPCPRHKSCPRHSPCPRHKSCPRHSLSRTVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T7I2</accession>
    <name>A0A433T7I2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_014710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000574">
        <property type="protein sequence ID" value="RUS77526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T7I2"/>
    <dbReference type="STRING" id="188477.A0A433T7I2"/>
    <dbReference type="OrthoDB" id="533331at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS77526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="250" mass="28368" checksum="23110646FE4074C5" modified="2019-05-08" version="1" fragment="single">MAANTCQPVVVPGHYNPMFKVDVNVHCPLREALASEADFKVDLLAHSLQLDTFCKQEQFQQALGKVDYHGKTGTSFQNKANLSFCNLQQTLTKYRGVMHEDTYEREPCFAQLFPNVVEYSKTGSTFKRPGTTPIDNYLKQLSHLNHVLTLARQIHEDIRYGEKPKYLAHQVAVLFQAIQAIPSGSELLARHKTNIEENFKMLKSTIADLHEFENSLPQEVEEWLLELTDSISGVVHSMPTQLSQELRPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T8V1</accession>
    <name>A0A433T8V1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_014286</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000541">
        <property type="protein sequence ID" value="RUS77940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T8V1"/>
    <dbReference type="STRING" id="188477.A0A433T8V1"/>
    <dbReference type="OrthoDB" id="10012075at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF253">
        <property type="entry name" value="DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019219107" description="Ig-like domain-containing protein" evidence="6">
        <location>
            <begin position="24"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="29"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="129"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="208"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="339"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS77940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="418" mass="47561" checksum="B4C0BC84FEF2E540" modified="2019-05-08" version="1">MCVTMKMWISLCLVIFLAHILSALTIMQPRMDTLRVNVTVKEKATAVLPCPIESLGEYKVIWTDEQATLLTHEDRRIIDDERISIERPYQFDWNLHIRDVRYSDQGIYRCQINTSPISIKIVNLFVEVPSEIVEHLTSTDVTAQEGDTVTLVCNATGIPPPKITWFSLPSGSDVRRQSELCKVSDSKPQLTHLYINVISCTVRMVFAPEIFLPNKRIGQKKGMETILECTVTAFPHAVSYWQKDGQKIITSRPKYRMDVYIEGDNRLTLSLRVFDINETDYGPYTCIAANKIGEDAETMFLYNYHKSSASSTTTRAPLLPPTSLSMVFPVTHRSMWTPDKKDGLSDFNTGDDLEEPVGQSEFGSRPEGHYATQHPRYTPQNSDRGRIMAGRNKERNSAATCSPRNIETLLFFIILYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TAG0</accession>
    <name>A0A433TAG0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycoside hydrolase 35 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_013732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000505">
        <property type="protein sequence ID" value="RUS78520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TAG0"/>
    <dbReference type="STRING" id="188477.A0A433TAG0"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase 35 catalytic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS78520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="198" mass="23270" checksum="1A66C128C4A87A20" modified="2019-05-08" version="1" fragment="single">MFQVENEYLSYGKDSNHVKLLLYMFRKYGLKELIITSDHEFDWRNKMLDLSKYALHTINGDQLDIRHMEFVKSQSPHFPIMVMELWCGWFDVWKNRKHQTQDSRLLNQFLSFLINNGSSFNLYMFIGGTNFGFTNGAINITKYEVITTSYDYDAPLTEAGDTTPKYFLIRELLLEFYKSIGIPYLPEVPPNLPKGNYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TB49</accession>
    <name>A0A433TB49_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_013433</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000488">
        <property type="protein sequence ID" value="RUS78815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TB49"/>
    <dbReference type="STRING" id="188477.A0A433TB49"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF14">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="16"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS78815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="311" mass="34933" checksum="D0C657267B310E09" modified="2019-05-08" version="1">MSRYLILNTGAKMPTIGFGTYLLQGDALRSSLDYALFLGYRLIDTASSYGNEADIGQVLRDRIQSGRMKRKDVYITTKIAKTHLKRASTIRCLQKSLHDLGTSYADAVLIHTPWGVVDTGPGSDTVEFDDVHFTETWTALQSLFQDGSARSIGVSNFTVKQIEQILDNGSPPPSHLQMECHAYLAQNKLKAFCDANNIVVTAYSPLGAPAYPVDDESERERRLLSDPCIAKISERVRKTPAQVLLTFLMQRGMAVVPKSKTNDRIKENFDSTNWKLSKKDFDIIMGLDCGVKYFKFKNRTGHPEFFPQEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TCV5</accession>
    <name>A0A433TCV5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Anaphase-promoting complex subunit 4 WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_012894</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000457">
        <property type="protein sequence ID" value="RUS79340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TCV5"/>
    <dbReference type="STRING" id="188477.A0A433TCV5"/>
    <dbReference type="OrthoDB" id="187712at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040067">
        <property type="entry name" value="WDR47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19863">
        <property type="entry name" value="NEMITIN (NEURONAL ENRICHED MAP INTERACTING PROTEIN) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19863:SF5">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="106"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="238"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS79340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="39570" checksum="87B7D8829A20848F" modified="2019-05-08" version="1" fragment="single">LEPTVLTGKNKTETRQSGVKSVSASQASLRRSSESSKSSSAGKPRFIPVTRLEDSQAIRTVAFHPKGNFYAVGSNSKMLRVCAFPSMGNLREEHVAYESSVVYKHGKHHKGSIYCSAWNPLGDLIATGSNDKTIRLAKFNEDTLSVEGPGMELSFHDGTVRDLVFMQDVTNHSSLLISGGAGDCKIYVTDCQSGAPIRAMAGHTGGYMEVWGWRCRGGGTRVGRWKCRGGGVLGAWVRSRTSSPFASVCVDPSGRLMVSGHEDGVVMLYDIRGAKVVQSFQPHVGECRSARFSNNAYYLLTVAYDNRIVITDLHGDLLRPLPSVVVGEHKDKVIQGRWHPTQFAFVTSSADKAAICWGLPTVQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TD98</accession>
    <name>A0A433TD98_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SID1 transmembrane family member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_012827</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SID1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000452">
        <property type="protein sequence ID" value="RUS79414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TD98"/>
    <dbReference type="OrthoDB" id="416618at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051033">
        <property type="term" value="F:RNA transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025958">
        <property type="entry name" value="SID1_TM_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12185:SF14">
        <property type="entry name" value="CHOLESTEROL UPTAKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12185">
        <property type="entry name" value="SID1 TRANSMEMBRANE FAMILY MEMEBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13965">
        <property type="entry name" value="SID-1_RNA_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019378496" description="SID1 transmembrane family member 1" evidence="9">
        <location>
            <begin position="25"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="548"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS79414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="568" mass="64470" checksum="340CAA8E4D9CC66F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TDZ3</accession>
    <name>A0A433TDZ3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GP-PDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_012410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000426">
        <property type="protein sequence ID" value="RUS79811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TDZ3"/>
    <dbReference type="STRING" id="188477.A0A433TDZ3"/>
    <dbReference type="OrthoDB" id="197419at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008889">
        <property type="term" value="F:glycerophosphodiester phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006580">
        <property type="term" value="P:ethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46320">
        <property type="entry name" value="GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46320:SF1">
        <property type="entry name" value="GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="73"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS79811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="346" mass="38537" checksum="832B0ABCD9CC934D" modified="2019-05-08" version="1">MLIPQKVMLLFGNVFVLWLLINTFITDSFGIALVLSAIIIGGIQYVRIPPVHHSKISESIEALFKVDQANHIKSTIFHKAGGYHAPENTLEAIQKAISLGIPAVEIDLEITSDGVGVLLHGPDLDATTGGHGRISKLTYEYIKSLNAAANDPNKDKYPSVRVPTIDECLRLCVENNLVVFIDCKSDAQRTAKMITHLYQKYPALYGLGVVCSFYPHLIYSVRQADSNIVTGVTHRSFYITLAGEDGVERNKELWKRILAPFADAVLDWAHTFLIWFLCGNSFFLCSKNKISRDLKSFYENLGVRLVAWTVNEPVEKRWMLDHLGIPVITDGLNMPSAIPGQSEKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TG87</accession>
    <name>A0A433TG87_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">JmjC domain-containing protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EGW08_011647</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">EC2010</strain>
            <tissue evidence="17">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000383">
        <property type="protein sequence ID" value="RUS80592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TG87"/>
    <dbReference type="STRING" id="188477.A0A433TG87"/>
    <dbReference type="OrthoDB" id="47172at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051864">
        <property type="term" value="F:histone H3K36 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031648">
        <property type="term" value="P:protein destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000019">
        <property type="entry name" value="Bifunctional peptidase and arginyl-hydroxylase JMJD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056520">
        <property type="entry name" value="ARM_KDM8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF106">
        <property type="entry name" value="BIFUNCTIONAL PEPTIDASE AND ARGINYL-HYDROXYLASE JMJD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24472">
        <property type="entry name" value="ARM_KDM8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019323574" description="JmjC domain-containing protein 5" evidence="15">
        <location>
            <begin position="22"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="16">
        <location>
            <begin position="289"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="160"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RUS80592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="432" mass="49001" checksum="635336B9DA77812D" modified="2019-05-08" version="1" fragment="single">SCCFNLLQASSVLSLLNKVVTLLYKGEYCSCLDLCQPALDKIWEELNTGYWKDVPLCWRQAYSLVSLAKALCESALLSEPGRNIDHAVILRTCDMGLLMGAPILGNILAKMSREFQRAFGILGQWRRLSETAQDDTLTSNGGVDVHKGLNRFSKLQSNKESNNITKNVQKSSEVGSQEPVVSSPKVTFPPRVHTQKTNEIPQCSCPSVEMFQAMFMDEGHPVIITNAIGYWPALTTRRWSLDYLRSVAGCRTVPVELGDRYTEESWTQKLMTIGEMIDQYVTKSNVDKAYLAQHQLFDQVWELKDDISVPVYCCLGEDEDVDINAWFGPAGTISPLHQDPKHNFLCQVMGTKYVRLYSEEHTECVYPHASRLLHNTSQVDVDDPDLEKFPKFKDVPCLEAVLQPGEMLYIPPKHWHYVKSLDVSFSVSFWWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TGT0</accession>
    <name>A0A433TGT0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_011507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000376">
        <property type="protein sequence ID" value="RUS80721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TGT0"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS80721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="186" mass="19880" checksum="D6CAA18E19144C05" modified="2019-05-08" version="1">MLIKRSRDSVITSEDVKLGLARTETCLVWDLLGLGLAWCGTCSAWDLLGLGLAWSGTCLVWDLLGLGFSRFVICSGFARQGFARTGIISVWDLLGLGLAWSGTCLVWDLLGLGFARSGICLVWDLLGLGLAWSGICSDLDLLVHIPLTSTLPVGKKLGSQCGTQTLNTLYSRSALLPQSYAAPSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TIS5</accession>
    <name>A0A433TIS5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_010772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000336">
        <property type="protein sequence ID" value="RUS81474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TIS5"/>
    <dbReference type="OrthoDB" id="6207206at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS81474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="166" mass="18746" checksum="A946F4D0732B86A9" modified="2019-05-08" version="1">MEDTEKDCEGYGNHRLNHREPISPDPRNSSKFSSLEERNDSGLGSLGYFSQEFNSGSLSLLEEEEKVQKAEPRDRPREISLHPETDSGTTPTFSTDLENSLSRLNIGSIKDKAFEQCDSGLDEHERDSVLAARSYLTQCANLHWVSPHFTPDQILEIFRGDEDGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TJT9</accession>
    <name>A0A433TJT9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_010406</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000319">
        <property type="protein sequence ID" value="RUS81814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TJT9"/>
    <dbReference type="STRING" id="188477.A0A433TJT9"/>
    <dbReference type="OrthoDB" id="6154550at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052579">
        <property type="entry name" value="Zinc_finger_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048324">
        <property type="entry name" value="ZSWIM1-3_RNaseH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21056">
        <property type="entry name" value="ZSWIM1-3_RNaseH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="460"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS81814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="630" mass="72100" checksum="D5A6C8D3D69B6FB6" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TLQ4</accession>
    <name>A0A433TLQ4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_009734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000283">
        <property type="protein sequence ID" value="RUS82520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TLQ4"/>
    <dbReference type="STRING" id="188477.A0A433TLQ4"/>
    <dbReference type="OrthoDB" id="6104743at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="694"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="776"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="866"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="776"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="872"/>
            <end position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS82520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1082" mass="121256" checksum="17C77316F6528754" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TMA9</accession>
    <name>A0A433TMA9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_009547</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000275">
        <property type="protein sequence ID" value="RUS82710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TMA9"/>
    <dbReference type="STRING" id="188477.A0A433TMA9"/>
    <dbReference type="OrthoDB" id="9000293at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000029">
        <property type="entry name" value="Acetylcholinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019182377" description="Carboxylesterase type B domain-containing protein" evidence="5">
        <location>
            <begin position="30"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="28"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS82710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="550" mass="60579" checksum="D996EBC2A72B8AA3" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TMP0</accession>
    <name>A0A433TMP0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cationic amino acid transporter C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_009365</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000268">
        <property type="protein sequence ID" value="RUS82843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TMP0"/>
    <dbReference type="STRING" id="188477.A0A433TMP0"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243:SF4">
        <property type="entry name" value="CATIONIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243">
        <property type="entry name" value="INNER MEMBRANE TRANSPORTER YGJI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="580"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="610"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="652"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="675"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="500"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="702"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="508"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="708"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="725"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS82843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="737" mass="80775" checksum="80AEF9CD068D6953" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TN20</accession>
    <name>A0A433TN20_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MMS19 nucleotide excision repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_009361</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the CIA complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the MET18/MMS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000267">
        <property type="protein sequence ID" value="RUS82896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TN20"/>
    <dbReference type="STRING" id="188477.A0A433TN20"/>
    <dbReference type="OrthoDB" id="342900at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039920">
        <property type="entry name" value="MMS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024687">
        <property type="entry name" value="MMS19_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029240">
        <property type="entry name" value="MMS19_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891">
        <property type="entry name" value="DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891:SF0">
        <property type="entry name" value="MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12460">
        <property type="entry name" value="MMS19_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14500">
        <property type="entry name" value="MMS19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="MMS19 N-terminal" evidence="7">
        <location>
            <begin position="39"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="MMS19 C-terminal" evidence="6">
        <location>
            <begin position="568"/>
            <end position="955"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS82896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1004" mass="111121" checksum="6EA6FDF5AB130EDB" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TNX3</accession>
    <name>A0A433TNX3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Katanin p60 ATPase-containing subunit A-like 2</fullName>
            <shortName evidence="8">Katanin p60 subunit A-like 2</shortName>
            <ecNumber evidence="8">5.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">p60 katanin-like 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">KATNAL2</name>
        <name evidence="11" type="ORF">EGW08_008957</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.</text>
            <dbReference type="EC" id="5.6.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
            <location evidence="1 8">Cytoskeleton</location>
            <location evidence="1 8">Spindle pole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
            <location evidence="8">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
            <location evidence="8">Cytoskeleton</location>
            <location evidence="8">Spindle</location>
        </subcellularLocation>
        <text evidence="8">Localizes within the cytoplasm, partially overlapping with microtubules in interphase and to the mitotic spindle and spindle poles during mitosis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 2 sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.1" evidence="8"/>
    <dbReference type="EMBL" id="RQTK01000250">
        <property type="protein sequence ID" value="RUS83277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TNX3"/>
    <dbReference type="STRING" id="188477.A0A433TNX3"/>
    <dbReference type="OrthoDB" id="191529at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008568">
        <property type="term" value="F:microtubule severing ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051013">
        <property type="term" value="P:microtubule severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19509">
        <property type="entry name" value="RecA-like_VPS4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000048">
        <property type="entry name" value="Katanin p60 ATPase-containing subunit A-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000434">
        <property type="entry name" value="Katanin p60 ATPase-containing subunit A-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03025">
        <property type="entry name" value="Katanin_p60_AL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027497">
        <property type="entry name" value="Katanin_p60_AL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF78">
        <property type="entry name" value="KATANIN P60 ATPASE-CONTAINING SUBUNIT A-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="324"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="119"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="332"/>
            <end position="339"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS83277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="577" mass="64267" checksum="1EF7898AB6587FC9" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TSF3</accession>
    <name>A0A433TSF3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_007744</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000203">
        <property type="protein sequence ID" value="RUS84505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TSF3"/>
    <dbReference type="STRING" id="188477.A0A433TSF3"/>
    <dbReference type="OrthoDB" id="9979716at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055470">
        <property type="entry name" value="DUF7042"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055471">
        <property type="entry name" value="DUF7043"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055472">
        <property type="entry name" value="DUF7044"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22255">
        <property type="entry name" value="LP06548P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22255:SF9">
        <property type="entry name" value="LP06548P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23069">
        <property type="entry name" value="DUF7042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23070">
        <property type="entry name" value="DUF7043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23071">
        <property type="entry name" value="DUF7044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019031076" evidence="3">
        <location>
            <begin position="23"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="599"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7044" evidence="6">
        <location>
            <begin position="28"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7042" evidence="4">
        <location>
            <begin position="127"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7043" evidence="5">
        <location>
            <begin position="264"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS84505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="621" mass="68823" checksum="C568B12B59BF42B8" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TSU6</accession>
    <name>A0A433TSU6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_007572</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000198">
        <property type="protein sequence ID" value="RUS84652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TSU6"/>
    <dbReference type="OrthoDB" id="6059212at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24039:SF28">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24039">
        <property type="entry name" value="FIBRILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="657"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="710"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="751"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS84652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="791" mass="86213" checksum="FC6943776F8DDC90" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TVL5</accession>
    <name>A0A433TVL5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIPF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_006616</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000164">
        <property type="protein sequence ID" value="RUS85604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TVL5"/>
    <dbReference type="STRING" id="188477.A0A433TVL5"/>
    <dbReference type="OrthoDB" id="440385at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="7">
        <location>
            <begin position="113"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS85604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="260" mass="28013" checksum="553D5CB48EF9579C" modified="2019-05-08" version="1">MSGFHQEGEFFQSNYYDNQNYGYDANAQAQFGVEPQFGQFDYSQGYGGSNQGYDQEFMAPDPRAPFTGSIMTPSPMAFEEKAGSGADNYEDEPPLMEELGINFDHIVQKTMAVLNPLKSADHTIMQDTDLAGPLVFCMAFGGSLLLSGKLHFGYIYGIGLVGCLAMYCLLNLMSLSGVSAGIIVSVLGYCLLPMVFLSFSAVLLSLKGVVGIVLVAATVLWCSVSASKLFVSALAMDSQQLLVAYPCTLVYGVFALLTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TXK5</accession>
    <name>A0A433TXK5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_005916</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000142">
        <property type="protein sequence ID" value="RUS86331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TXK5"/>
    <dbReference type="STRING" id="188477.A0A433TXK5"/>
    <dbReference type="OrthoDB" id="6147675at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050752">
        <property type="entry name" value="C2H2-ZF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384:SF189">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384">
        <property type="entry name" value="FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="215"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="253"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS86331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="336" mass="38513" checksum="466CFCC60D3980C1" modified="2019-05-08" version="1" fragment="single">CSLCAAHFKSQTGLRQHMEVKHGTNPSLRCPICGKIMYNKTNLEGHMNKHKGIKPFSCPLCKKSFYFAMASMYVGSPSSYSGHMSTKGYSMKSTPKSFPRALVCKVCNTAWNSSDEHRRHMCQAHKYLSCQKCHTLCPTSGALRSHMNREHTPKLVCPICNKMFHCRVNYSGHMNMHSGTKPYACDKCGKRFAYQQSRSAHEKIYQLWSKSGNSYSCSLCTYSTTYRNRVRGHCRSVHMGIPRKYKGNEKGLFMCDKCGKEFTSSRGFRMHTLSKHLNQYPYHCQECSKGFMSVATHRDHMNMHAGIALQCMGCETLFYTEYGLKRHLLRKHPELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TZZ0</accession>
    <name>A0A433TZZ0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_005069</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000118">
        <property type="protein sequence ID" value="RUS87137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="188477.A0A433TZZ0"/>
    <dbReference type="OrthoDB" id="118234at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030514">
        <property type="term" value="P:negative regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1180">
        <property type="entry name" value="MAN1, winged-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052277">
        <property type="entry name" value="INM_ESCRT-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003887">
        <property type="entry name" value="LEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018996">
        <property type="entry name" value="Man1/Src1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041885">
        <property type="entry name" value="MAN1_winged_helix_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13428:SF12">
        <property type="entry name" value="INNER NUCLEAR MEMBRANE PROTEIN MAN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13428">
        <property type="entry name" value="INNER NUCLEAR MEMBRANE PROTEIN MAN1 LEM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09402">
        <property type="entry name" value="MSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50954">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="508"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="LEM" evidence="9">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="44"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="297"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS87137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="587" mass="65812" checksum="24DEAE58DE4F6DD6" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U2N8</accession>
    <name>A0A433U2N8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FHOD1 N-terminal GTPase-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_004118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000093">
        <property type="protein sequence ID" value="RUS88065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="9806920at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="691"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="634"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="654"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS88065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="822" mass="91388" checksum="937198932B76181F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U3V4</accession>
    <name>A0A433U3V4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_003759</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000081">
        <property type="protein sequence ID" value="RUS88501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U3V4"/>
    <dbReference type="OrthoDB" id="6083317at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS88501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="230" mass="26966" checksum="7D2210171CB399B1" modified="2019-05-08" version="1">MAGLKLPSNPKRRRARQEPELDLYLARRAKCPYGCLPGQCLNGRCPARMIGHRLLCPHPDLEAQAAARQKQRDEEAERQSKADMEVFLAEERRLMAMRNPKKDENEEDEDILRPSKAFLEFINRKQPTKSMRPPARPLCMLEAADYKPPSGDYSELSRFLRLSTMPGYSSNDHMTQYRSVHSQDVWDGQKDLQRQAFRMKRDWLSVWGEFNVKEQRWRKAWVEKFGADKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U553</accession>
    <name>A0A433U553_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_003277</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000070">
        <property type="protein sequence ID" value="RUS88941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U553"/>
    <dbReference type="STRING" id="188477.A0A433U553"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18445">
        <property type="entry name" value="BACK_KLHL2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000002">
        <property type="entry name" value="Kelch-like family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000001">
        <property type="entry name" value="Kelch-like family member 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF466">
        <property type="entry name" value="RING CANAL KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00501">
        <property type="entry name" value="KELCHREPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="2" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="8">
        <location>
            <begin position="76"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS88941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="614" mass="67988" checksum="0B11BF56E9D83427" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U704</accession>
    <name>A0A433U704_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_002637</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000051">
        <property type="protein sequence ID" value="RUS89619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U704"/>
    <dbReference type="STRING" id="188477.A0A433U704"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS89619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="157" mass="17452" checksum="EF74F920FE9A3238" modified="2019-05-08" version="1" fragment="single">IPVPLPHTNKMIHVNIPVPLPHTSKVIRINIPVPLPHTNKVIRVNIPVPLPHTSKVIHVNIPVPLPHTNKVIRINIPVPLPHTSKVIHVNIPVPLPHTNKVIRVNIPVPLPHTNKVIHVNIPVPLPHTSKVIRVNIPVPLPHTNKVIRINIPVPLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U9P0</accession>
    <name>A0A433U9P0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_001754</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RBR family. Ariadne subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="3"/>
    <dbReference type="EMBL" id="RQTK01000031">
        <property type="protein sequence ID" value="RUS90486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U9P0"/>
    <dbReference type="STRING" id="188477.A0A433U9P0"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20343">
        <property type="entry name" value="BRcat_RBR_HHARI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20356">
        <property type="entry name" value="Rcat_RBR_HHARI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16626">
        <property type="entry name" value="RING-HC_RBR_HHARI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000002">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000019">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045840">
        <property type="entry name" value="Ariadne"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048962">
        <property type="entry name" value="ARIH1-like_UBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19422">
        <property type="entry name" value="Ariadne"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21235">
        <property type="entry name" value="UBA_ARI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="136"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS90486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="511" mass="59909" checksum="AAA8D69942F9CA13" modified="2019-05-08" version="1">MDSDDGFMDGCDESDDSRVLSDNDDDDELPMDMEPPEASSSERRDEDDFAYEVLTADQIVEFMVDCIKEVNAVVQIPATITRILLNHFNWDKEKLMERYYDGDQDKLFSEAHVVSPHRRDPAKTARRSGRNTVQEENLLCEICFFSKALNDMKGLECGHRFCAQCWAEYLTSKIMDEGMGQTISCAAYGCDILVDDKNVMDLIKDQRVKLKYQQIITNSFVECNRLLRWCPAPDCGHAIKVAHHDAKAVTCHCGHTFCFSCGENWHDPVRCKWLKQWIKKCDDDSETSNWIAANTKECPKCHVTIEKDGGCNHMVCKNQNCKADFCWVCLGPWEPHGSSWYNCNRYNEDDAKKARDSQERSRAALQRYLFYCNRYMNHMQSLKFEHALYQSIKTKMEEMQQHNMSWIEVQFLKKAVDVLCLCRQTLMYTYVFAFYLKKNNQSIIFEDNQKDLENATEQLSEYLEREISSEVLHDIKQKVQDKYRYCESRRNVLLDHVHEGYEKDQWEYLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UBG4</accession>
    <name>A0A433UBG4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">U6 snRNA-associated Sm-like protein LSm5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LSM5</name>
        <name evidence="15" type="ORF">EGW08_001057</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">EC2010</strain>
            <tissue evidence="15">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the precatalytic spliceosome (spliceosome B complex). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 form a heptameric, ring-shaped subcomplex (the LSM2-8 complex) that is part of the U4/U6-U5 tri-snRNP complex and the precatalytic spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000017">
        <property type="protein sequence ID" value="RUS91144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UBG4"/>
    <dbReference type="STRING" id="188477.A0A433UBG4"/>
    <dbReference type="OrthoDB" id="429711at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01732">
        <property type="entry name" value="LSm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000003">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033871">
        <property type="entry name" value="LSm5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971:SF0">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 13" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 13" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 13" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="14">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RUS91144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="76" mass="8414" checksum="258AFE394E2B051E" modified="2019-05-08" version="1" fragment="single">ELVDKCIGSRIHIIMKNDKEIVGTLLGFDDFVSILCRTIVFESTPEGRRVTRLDKLLLNGNNITMLVPGGEGPETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UC53</accession>
    <name>A0A433UC53_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_000794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000011">
        <property type="protein sequence ID" value="RUS91470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UC53"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS91470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="191" mass="20106" checksum="AC7D368BD641CAE1" modified="2019-05-08" version="1" fragment="single">MWLTRTQTLAKFGASARTAAGAVRAKMLLTGTSVQNSHLFSSVVKPLPVPARLHGNSWKYTVAMMTRFPARNFRIQTSMSDKVPAELSSSSSFSASSSSSSYSPSSSSSPPGAVPDSTNELLPERSGSRSRPNALARSSPVPHRRISTGTPQENSVLGYQDYADANASTGAGASASAVNEQVQIRRAGLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UCA7</accession>
    <name>A0A433UCA7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_000760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000011">
        <property type="protein sequence ID" value="RUS91436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UCA7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS91436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="410" mass="51033" checksum="12898D5E32AFB96D" modified="2019-05-08" version="1">MRNKHCRIYKLLRVCCMRNKHCRIYKLLRVCCMRNKHCRIYKLLRVCCMRNKHCRIYKLLRVCCMRNKHCRIYKLLRVCCMRNKHCRIYKLLRVCCMRNKHCRIYKLLRVCCMRNKHCRIYKLLRVCCMRNKHCRIYKLLRVCCMRNKQCRIYKLLRVCCMRNKHCPIYKLLRVCCMRNKHCRIYKLLRVCCMRNKHCRIYKLLRVCCMRNKHCRIYKLLRVCCMRNKHCRIYKLLRVCCMRNKHCPIYKLLRVCCMRNKHCRIYKLLRVCCMRNKHCRIYKLLRVCCMRNKHCRIYKLLRVCCMRNKHCRIYKLLRVCCMRNKHCRIYKLLRVCCMRNKHCRIYKLLRVCCMRNKHCPIYKLILKTFIVNVQCICDRNVLQFVYVCKSCVSCVMVWSGSITQLHVLTFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UD24</accession>
    <name>A0A433UD24_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_000485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000006">
        <property type="protein sequence ID" value="RUS91777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UD24"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019505395" evidence="1">
        <location>
            <begin position="22"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS91777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="106" mass="12247" checksum="7C0892DF5D6FB936" modified="2019-05-08" version="1">MRTGLILACLVWAVLATAALAVYPQPCTRQNDNAERKVCSGKNQLRNSQKSFTLCCLRADRFPFLERIPIEQTVIEKLQGKQRYETTCKCRGQRDICQRRPSRCRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z142</accession>
    <name>A0A3S0Z142_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_023782</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01002777">
        <property type="protein sequence ID" value="RUS68455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z142"/>
    <dbReference type="STRING" id="188477.A0A3S0Z142"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS68455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="102" mass="12202" checksum="10C8018C7CF153A3" modified="2019-04-10" version="1" fragment="single">FLLHIVADLRHFLLRIVAVLRHSVLRIVADLRHFLLRIVADLRHFLLRIVADLRHFLLCIVADLRHFLLRIVADLRHFLLRIVADLRPFVLRIVADLRHFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z1C5</accession>
    <name>A0A3S0Z1C5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_023658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01002284">
        <property type="protein sequence ID" value="RUS68580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z1C5"/>
    <dbReference type="OrthoDB" id="6116421at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS68580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="16185" checksum="27FE5BCAC2FE241D" modified="2019-04-10" version="1" fragment="single">DGIWRRAPNATPGFLRGKVQCRLNNTLVWLDNMPDEKKITTVRFAISQGYQARTSAAIEEKATNLEVQARRKFMAQKRDKRRRNQRSRKIFKSLEGAVVDETLSDQVVVMIDKIKNNVRSLCGLLFTHIWEEDDGGDMLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z1K3</accession>
    <name>A0A3S0Z1K3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin-dependent kinase 2-interacting protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_023512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01002058">
        <property type="protein sequence ID" value="RUS68727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z1K3"/>
    <dbReference type="STRING" id="188477.A0A3S0Z1K3"/>
    <dbReference type="OrthoDB" id="17066at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023250">
        <property type="entry name" value="Cyclin-dep_Kinase_2_interact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15827">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 2-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15827:SF2">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 2-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02040">
        <property type="entry name" value="CDK2IP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS68727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="23767" checksum="B4D666CEABCCA5F4" modified="2019-04-10" version="1">MAQSKESPEAATVLSPVSVKTPRHGAGNLTGNPRKVKDLAADFHNYIMKWEVLNSKGMEIVTKIANIKIEKVYDAQQVGDGEKRVTLPLELNPLCDSLAEVIESMAVLESKLSYKAKNAEALAALEQLHPSSNDDSTLLFNTMTLQDVAVTTKEIQYDFHKELQLKRVLLSKVAHASSREESEVLAACWLHQPYIKPQCYDLVQALLKETGHVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z4C8</accession>
    <name>A0A3S0Z4C8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_023124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001826">
        <property type="protein sequence ID" value="RUS69116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z4C8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS69116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="127" mass="13963" checksum="9E6FDCC8A2E6AD78" modified="2019-04-10" version="1" fragment="single">HNKFNENLKEKNSPVLGQVLEVLVVLEVLVVLKVLVLVVLKVLVVLEVLVVLEVLVVLKVLVLVVLKVLVLVVLKVLVLVVLVVLKVLVLVGHVVLCGLFLLVLVSDHTTQLRQEPQRLGVEQQSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z6J8</accession>
    <name>A0A3S0Z6J8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ARF7 effector protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_020450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001159">
        <property type="protein sequence ID" value="RUS71781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z6J8"/>
    <dbReference type="STRING" id="188477.A0A3S0Z6J8"/>
    <dbReference type="OrthoDB" id="5984406at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029264">
        <property type="entry name" value="ARF7EP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46536:SF3">
        <property type="entry name" value="ARF7 EFFECTOR PROTEIN C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46536">
        <property type="entry name" value="ARL14 EFFECTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14949">
        <property type="entry name" value="ARF7EP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ARF7 effector protein C-terminal" evidence="2">
        <location>
            <begin position="128"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS71781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="239" mass="26669" checksum="0E153EC4DF663AF4" modified="2019-04-10" version="1" fragment="single">TLKWNAVPTLFDIPNPPPKPTPKRKHTIRAAPEVHSKKTKSNISQASQVMADQTQSSNPNQSAFFGNSEPISIDSDSDNSSDNGSVHEVIGDEDSNSNSNSNTNSNTLSQRTRSSNAEKNIEDLTRLELKKLSLDAHGTFMADFDPEKSKREIRKMNRRLYAKGSKRMRLYNEKGQLLESLVDICDCLNTKCPGCHFPCPKCGSAKCGTECRCNRKYTINYIEVEGTNKTFSFSPEKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z7B5</accession>
    <name>A0A3S0Z7B5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bestrophin homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_019923</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Forms chloride channels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001082">
        <property type="protein sequence ID" value="RUS72315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z7B5"/>
    <dbReference type="STRING" id="188477.A0A3S0Z7B5"/>
    <dbReference type="OrthoDB" id="201595at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000615">
        <property type="entry name" value="Bestrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736">
        <property type="entry name" value="BESTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0868">Chloride</keyword>
    <keyword evidence="6" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="163"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS72315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="315" mass="35780" checksum="A6E86EBC50D58558" modified="2019-04-10" version="1" fragment="single">MTIIYQYRVATTSLGGFLRLLRAWRGSVYKLLYKELLIFLSLYALVSLTYRLALAPAQKRQFESLALDLRSVSTSMPLSFVLGFYVTVIVQRWWEQFKNVPWPDRTLFIMCTYLPGTEDRERILRRTVARYMLFGMIIICRSVSVAVMKRFPTIDHIVEAASSSSSSSSSSSSSSSSPPSSSSSTSSSSISSSSPCWLVSSQLADFRDKCSSCFVYDWITVPLVYTQVVTFGVYSYFAVSLIGQQYLDTGQKYEGNEHDWFVPGFTVLQFLFYMGWLKVAEQMINPFGEDDDDYDINWLIDRHTAVSGKTATKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z985</accession>
    <name>A0A3S0Z985_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_018607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000915">
        <property type="protein sequence ID" value="RUS73634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z985"/>
    <dbReference type="OrthoDB" id="6168814at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018546951" evidence="1">
        <location>
            <begin position="17"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS73634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="181" mass="20449" checksum="073A8B153F4C43E4" modified="2019-04-10" version="1">MKLLLLVALLAPMVLASLDICYPPQSTTVGFLTLSEAHSYSINDYENGILYFAPGNDIFGEPWTYVDLNANITYHKEGGKPCVYQALDPEVRELFHQCLPDDAKLYGEIDGHPMYLTDRPGSIKWLMAVTPIKDTPYYWRFISRFEYRGSLTDVGFVYINNLGILEPSLLDKDLSVCVAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z9C2</accession>
    <name>A0A3S0Z9C2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA replication complex GINS protein PSF3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_022467</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.</text>
    </comment>
    <comment type="function">
        <text evidence="6">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GINS3/PSF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001581">
        <property type="protein sequence ID" value="RUS69771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z9C2"/>
    <dbReference type="STRING" id="188477.A0A3S0Z9C2"/>
    <dbReference type="OrthoDB" id="10251744at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11713">
        <property type="entry name" value="GINS_A_psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21693">
        <property type="entry name" value="GINS_B_Psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010492">
        <property type="entry name" value="GINS_Psf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038437">
        <property type="entry name" value="GINS_Psf3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055221">
        <property type="entry name" value="PSF3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22466">
        <property type="entry name" value="PSF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF3 N-terminal" evidence="8">
        <location>
            <begin position="15"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="GINS subunit" evidence="7">
        <location>
            <begin position="84"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS69771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="210" mass="23656" checksum="B86E3CAD085B0E22" modified="2019-04-10" version="1">MAAYSVDLSTGNNYFDLNDIIASQEKIPCIFNIAVEGLGYLDQSTPDPDIGVGTKLELPLWLAKYLHRDARGIVSVETPKTYREGYRQILAADPSVVDLHRLGPHFYLAGGKLALFSLPDIHDILKTLLQTFQGRFRRIMDGSQNALHTDLTNQITMLDESERCLFAAGQRGLLDFQSWENRESEKLSTSTVVLNQRKRKWVGISRENGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZBF8</accession>
    <name>A0A3S0ZBF8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_018360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000891">
        <property type="protein sequence ID" value="RUS73874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZBF8"/>
    <dbReference type="STRING" id="188477.A0A3S0ZBF8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000837">
        <property type="entry name" value="AP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002112">
        <property type="entry name" value="Leuzip_Jun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351:SF24">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351">
        <property type="entry name" value="FOS TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00043">
        <property type="entry name" value="LEUZIPPRJUN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="5">
        <location>
            <begin position="167"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="103"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="169"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="558"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="298"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="561"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS73874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="635" mass="70117" checksum="4F04C8D7C4911084" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZCM0</accession>
    <name>A0A3S0ZCM0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transferrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_017599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000812">
        <property type="protein sequence ID" value="RUS74645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZCM0"/>
    <dbReference type="STRING" id="188477.A0A3S0ZCM0"/>
    <dbReference type="OrthoDB" id="5310573at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35841">
        <property type="entry name" value="PHOSPHONATES-BINDING PERIPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35841:SF1">
        <property type="entry name" value="PHOSPHONATES-BINDING PERIPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12974">
        <property type="entry name" value="Phosphonate-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS74645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="30593" checksum="6CC15333F0D0097F" modified="2019-04-10" version="1">MCPDIPVSTFAFLRNCIEEVTGLETDLIVEDRFKGPVPERANPFTDDLADIVALHSTNYLELKAQNQDHMELCPMAPVFQHHHAAGRPIYFSEIIVHARNKDKYKDLLDLKGCSWAYNDKNSLSGNVIVLNHLKKELKTNANHFGNFVESGSHLNSIKMVRDATVEAAAVDSAVLAGYLQEHEDDKDNFISLASLGPLPIFPFLFNDRLPDQIKRKITKEFLAFSTISKWKKRLNEMGIEKFAPVSNDLYSIEQELFNDVKGMSINTAYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZCX3</accession>
    <name>A0A3S0ZCX3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HotDog ACOT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_017357</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000791">
        <property type="protein sequence ID" value="RUS74869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZCX3"/>
    <dbReference type="STRING" id="188477.A0A3S0ZCX3"/>
    <dbReference type="OrthoDB" id="331699at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03442">
        <property type="entry name" value="BFIT_BACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655:SF0">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="5">
        <location>
            <begin position="257"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS74869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="329" mass="37417" checksum="50E61F36AEF4D775" modified="2019-04-10" version="1" fragment="single">MAVSCRRLLRLSPMTWAKHLANFSSHPGEMLTIKEVRQNLMENVGVRTKWGKENPWQEPNLMQPVVESQSQLPRRKPSDSLVRARIPLTDPEAREKYLLFNGGIRFGRLLEDFDTLAEQSTSSEQSLSGQKDIYIQGNVTWVGKSSMECSMFMEQEVDGVVHKFLSAKYLFAARNPLNNKAGIINPLDPQTPEEKAAFKLGEENKKLRTQEGSKSLLKTPPTESERLIIHDIFLSTVNQDSGSLRVRLKPENTVWMEDTILKSLIICHPEQRNLYNKIFGGFLMRGAYELAWITASVYSKKRPGMCKVVDDILFMKPVEIGSLLFLSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZEI5</accession>
    <name>A0A3S0ZEI5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_015144</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000611">
        <property type="protein sequence ID" value="RUS77089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZEI5"/>
    <dbReference type="STRING" id="188477.A0A3S0ZEI5"/>
    <dbReference type="OrthoDB" id="5969463at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF224">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="482"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="80"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="329"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="381"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS77089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="553" mass="62258" checksum="F20D89F6C377BC3C" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZF36</accession>
    <name>A0A3S0ZF36_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">small monomeric GTPase</fullName>
            <ecNumber evidence="2">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_014763</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="2"/>
    <dbReference type="EMBL" id="RQTK01000578">
        <property type="protein sequence ID" value="RUS77457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZF36"/>
    <dbReference type="STRING" id="188477.A0A3S0ZF36"/>
    <dbReference type="OrthoDB" id="18798at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051065">
        <property type="entry name" value="Ras-related_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45704">
        <property type="entry name" value="RAS-LIKE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="204"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS77457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="261" mass="30339" checksum="13D417AC20460A14" modified="2019-04-10" version="1">MSGRRALHRNGNSPEFNLALVGALGVGKSALTVKYITRRFIMEYDPDLEGTYTKHEDWDGQTVTVHVMDTCDKEDNDPSRYLKWADAFLVVYSITSSQSFQVAREYMESISLYLKSQGRECPVALVGNKIDLERYRQVNKSEGASLATEYETVFYETTAAEEYELLERVFQRIIQEAHFDKYGHILQPIYVADDRPMAWGQNNHQTLQHHQSSQSQLHQQQHPTQLHPQHRRPKSPKGTIEKKDEKNQQKKTLNKFFKIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZGM1</accession>
    <name>A0A3S0ZGM1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_015072</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000604">
        <property type="protein sequence ID" value="RUS77165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZGM1"/>
    <dbReference type="STRING" id="188477.A0A3S0ZGM1"/>
    <dbReference type="OrthoDB" id="343114at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF837">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="170"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="354"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="537"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="356"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="537"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="552"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="588"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS77165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="755" mass="85102" checksum="78008E33378C9DC2" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZGV7</accession>
    <name>A0A3S0ZGV7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_014912</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000589">
        <property type="protein sequence ID" value="RUS77336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZGV7"/>
    <dbReference type="STRING" id="188477.A0A3S0ZGV7"/>
    <dbReference type="OrthoDB" id="6091802at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="77"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS77336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="386" mass="42903" checksum="5CD5687DE94F49D0" modified="2019-04-10" version="1">MRNSTSAPVFTTSAPVFTTSAPVFTTSAPVFTITALVYGLGTSSNRPDYDMPEWIFSYIMEYISCAMVTVAFFGLIGNTIIIITLVKMGFATPINISFCALCISDCFYIVAIAWNAICFIPAFANSDLPFRARDVAIPTGGAVGNIFCGTTAWITAYISLERCLCAVFPLKIKKIVSPGKTLFSVCAIFIVTVPFIYLPFYDFVFYTQFDEDKNQTFIGVEKRNTALAKSIHRAHFIYRAVFVYSLPLVIILVCSVALAVSLKRSISWRQRQSSKSVEINNSSQQRSSKDARVVKTVLALATVYIFLGGLSSVRTLVTLMWPEFLVTGPYGRWNRSTASLTSLFSLINSSVNVLIYYKTGSKFRKTVNQMVCLNYGQPQSRFCLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZHB0</accession>
    <name>A0A3S0ZHB0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_017366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000791">
        <property type="protein sequence ID" value="RUS74878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZHB0"/>
    <dbReference type="OrthoDB" id="6154436at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="624"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="669"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="721"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="926"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="624"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="674"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="750"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="829"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="963"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="990"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS74878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="990" mass="106135" checksum="CC069E5B705BDE1E" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZJQ4</accession>
    <name>A0A3S0ZJQ4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Integrin beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">EGW08_015885</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">EC2010</strain>
            <tissue evidence="25">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Cell membrane</location>
            <topology evidence="1 18">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the integrin beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000669">
        <property type="protein sequence ID" value="RUS76355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZJQ4"/>
    <dbReference type="STRING" id="188477.A0A3S0ZJQ4"/>
    <dbReference type="OrthoDB" id="410592at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000043">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000002">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="EGF"/>
    </dbReference>
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        <property type="entry name" value="EGF_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040622">
        <property type="entry name" value="EGF_integrin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033760">
        <property type="entry name" value="Integrin_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015812">
        <property type="entry name" value="Integrin_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014836">
        <property type="entry name" value="Integrin_bsu_cyt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012896">
        <property type="entry name" value="Integrin_bsu_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036349">
        <property type="entry name" value="Integrin_bsu_tail_dom_sf"/>
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    <dbReference type="InterPro" id="IPR002369">
        <property type="entry name" value="Integrin_bsu_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082">
        <property type="entry name" value="INTEGRIN BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082:SF60">
        <property type="entry name" value="INTEGRIN BETA-PS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07974">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18372">
        <property type="entry name" value="I-EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08725">
        <property type="entry name" value="Integrin_b_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00362">
        <property type="entry name" value="Integrin_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17205">
        <property type="entry name" value="PSI_integrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002512">
        <property type="entry name" value="Integrin_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01186">
        <property type="entry name" value="INTEGRINB"/>
    </dbReference>
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        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00187">
        <property type="entry name" value="INB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01241">
        <property type="entry name" value="Integrin_b_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01242">
        <property type="entry name" value="Integrin_B_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69687">
        <property type="entry name" value="Integrin beta tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52047">
        <property type="entry name" value="I_EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 18" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 18" id="KW-0401">Integrin</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <keyword evidence="5 18 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018738396" description="Integrin beta" evidence="20">
        <location>
            <begin position="22"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="714"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin beta subunit VWA" evidence="22">
        <location>
            <begin position="26"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="452"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="503"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="584"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin beta subunit tail" evidence="24">
        <location>
            <begin position="626"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin beta subunit cytoplasmic" evidence="23">
        <location>
            <begin position="737"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="30"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="245"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="420"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="449"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="467"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="476"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="522"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="524"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="529"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="540"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="560"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="562"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="567"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="578"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="599"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="606"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="626"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="634"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR002512-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM01241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="SMART" id="SM01242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="RUS76355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="785" mass="86447" checksum="6B0699E06BC5F26D" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZQF9</accession>
    <name>A0A3S0ZQF9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-carbonic anhydrase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_008881</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000246">
        <property type="protein sequence ID" value="RUS83378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZQF9"/>
    <dbReference type="STRING" id="188477.A0A3S0ZQF9"/>
    <dbReference type="OrthoDB" id="5978072at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF208">
        <property type="entry name" value="CARBONIC ANHYDRASE XA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018726376" description="Alpha-carbonic anhydrase domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="4">
        <location>
            <begin position="23"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS83378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="326" mass="36813" checksum="9EE97BD792D8046F" modified="2019-04-10" version="1">MDVMLRLVTLCFHTFFIGINSEDPWTYDGRANVLKPSWHLCHKGKFQSPINVVPRMLLYDPMLRRLETQIPDTISGTLINKDNDLTFYVDNNTWNLANFSGGPFMYGYTLSEIKVKIGKTQSDGSEHRVDGRAFSAEIQLICYNSDLTNSLRKAQMLPYGVAIISIFAEAHPKEGNSAFSVFVDAASRVPWQGQDTHVPSLGLKAMLPDTIYYVTYEGSFTQPACLETVTWLIFNKPIKIKATQLDKLRHLRKRNQERSGTVTQNHIRTTMPLHNRPIRTNINTQKKRGSLCTMKRDAFYQSNECPDSSPTTGVPDKSALAPCGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZRT8</accession>
    <name>A0A3S0ZRT8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_007896</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SAAL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000208">
        <property type="protein sequence ID" value="RUS84364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZRT8"/>
    <dbReference type="STRING" id="188477.A0A3S0ZRT8"/>
    <dbReference type="OrthoDB" id="2156856at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052464">
        <property type="entry name" value="Synovial_Prolif_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23424:SF23">
        <property type="entry name" value="PROTEIN SAAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23424">
        <property type="entry name" value="SERUM AMYLOID A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS84364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="330" mass="36408" checksum="8A8447C3776E9C1C" modified="2019-04-10" version="1" fragment="single">DLAEEAEFEVEEQLGNPAPPPDVDLEKLRGDRIGDTVFSGKWCIQTVMKLMQADVDNSTDAVPMKADVGDNSADIVDMDEELQNEIGALWDMTSNVQVCQYLHSVGAVESICYVISNSRCPRATEMCVGMLANIVYHNELWDIMKSDKSFFSILIQLLTSTDQPVLLEVNRFINTGLCHASCEVFYASLTESGQLVTQELLRILSGSTNGDLLKQATELVYSLMYRDEKDDQFNARFAQPDFVLALLEASSEIGLSHETPGQNYLMEIFHSFTTYEAGVWAIGCALEEICAAGSGYLRTLCQDALSVASRCQVLTAILGTQHHGMGRGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZS52</accession>
    <name>A0A3S0ZS52_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_010799</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000338">
        <property type="protein sequence ID" value="RUS81415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZS52"/>
    <dbReference type="OrthoDB" id="5954868at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31389">
        <property type="entry name" value="LD39211P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31389:SF4">
        <property type="entry name" value="LD39211P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS81415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="240" mass="28234" checksum="02F99BF6B3A1129F" modified="2019-04-10" version="1" fragment="single">QAMFKDLHEKVLPVLTNFTLVVFDLGLNAVEREQVRTYCRCTFLHFPFEKFPEYFRTLKCFAWKVTAIRAMYEKANLVMWTDTSIRYTNPQVLLQFMDRARKRGLQQRLQPFHVPNPYHTLTQMFEHFGDSPCAHMAFHQVETGFGLYHKEPLIQHAVLDPWYACAVRGVCICPVEQKTVQSCPDIRGSTKIGVCMRNEQSAISLILAKVFREKYRAIVVRVGSFQRAMREHRYPYFKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZTX3</accession>
    <name>A0A3S0ZTX3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_006530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000161">
        <property type="protein sequence ID" value="RUS85736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZTX3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS85736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="134" mass="15950" checksum="E3A4A1C02A97605D" modified="2019-04-10" version="1">MRSSTWRRRRKPRGSQRRRRRAKDEQGVVQVQMEEDMQNELKEEQKKVREEGRKRGRRKEQEEELHSCQLLRKQIQILFLALLVTANLSDDHAINIDLNTNLTITLNMNPGIVLFNKCVFLFVFIFLSCVCVFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZXC9</accession>
    <name>A0A3S0ZXC9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_006840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000171">
        <property type="protein sequence ID" value="RUS85397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZXC9"/>
    <dbReference type="STRING" id="188477.A0A3S0ZXC9"/>
    <dbReference type="OrthoDB" id="6160103at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000001">
        <property type="entry name" value="semaphorin-5A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038877">
        <property type="entry name" value="THSD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16311">
        <property type="entry name" value="THROMBOSPONDIN TYPE I DOMAIN-CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16311:SF3">
        <property type="entry name" value="THROMBOSPONDIN TYPE-1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS85397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="135" mass="14941" checksum="6B0B7DD7BEA57929" modified="2019-04-10" version="1" fragment="single">GWSAWSDWSECSATCGKGKQKRYRTCTEPAPSEKYGQPCHGDQQQAVTCNFCNDVPNTADPVYVSRDQATATADKDPDVSLYIGLCVAVALVLIVVIIIVVFLCRKHNRRRSTFRDLGPDATQSLTEDEKKQKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZZQ0</accession>
    <name>A0A3S0ZZQ0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">BCL2/adenovirus E1B 19 kDa protein-interacting protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_005185</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NIP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000121">
        <property type="protein sequence ID" value="RUS87032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZZQ0"/>
    <dbReference type="STRING" id="188477.A0A3S0ZZQ0"/>
    <dbReference type="OrthoDB" id="5857140at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097345">
        <property type="term" value="P:mitochondrial outer membrane permeabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010548">
        <property type="entry name" value="BNIP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15186:SF5">
        <property type="entry name" value="BNIP3, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15186">
        <property type="entry name" value="RE48077P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06553">
        <property type="entry name" value="BNIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="24"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS87032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="22643" checksum="A3580B08738ADBAC" modified="2019-04-10" version="1">MASSARPEQRTDDLNDSWVELHYQSSPVKSGQPVEILSSSTDPSCGDCSPLPISCSTGSMERLLIDAQRESRTPSRPNSNQSSQGGSPKSPSSPNSEWSNEEWRSKQDPGTEWMWDWSSRPEVHQSFDSMYEKFRHPAGVASKRHSPLSVRNTKVMSNARIFSLTNLPTLLLTHACTFFLGAAAVIIYFKKYCNISAIAQATLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A0V1</accession>
    <name>A0A3S1A0V1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_001209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000020">
        <property type="protein sequence ID" value="RUS90992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A0V1"/>
    <dbReference type="OrthoDB" id="6144079at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS90992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="265" mass="29840" checksum="AF45A8D00989D23A" modified="2019-04-10" version="1" fragment="single">MMSFRRYSYGEEMSHPIPLPCLEHLPRLQPYQHSAENIRPNNSNANNNTTRPGVFVSQTNILSDAQDNACNYNVRGNQVTKRESLPKNLQDLDLTIRDEFEQIKKQYQKKGGDHTLSVINSNNVNRSKHSPKTSKKSTAYHSHSFSSNGEDSILKADQAPFRPSPCPTPGFLAFQNQHGQSGTGKVSNNARLGPELFKEYSLDLDNHRPVDKMDVDMEDIDDKRCRKHVIFLLLVMLVVVVAATVAVLTLTLGMKFTKKLITSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A376</accession>
    <name>A0A3S1A376_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_002729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000054">
        <property type="protein sequence ID" value="RUS89496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A376"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS89496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="141" mass="15601" checksum="961ED92DA546EAE9" modified="2019-04-10" version="1" fragment="single">LKSIVCLFLELGLLHCLNAIVCLFLELGLLHCLNAIVCLFLELGLLHCLNAIVCLFLELGLLHCLNAIVCLFLELALLHCLNAIVCLFLELGLLHCLNAIVCLFLELGLYHCLNAIVCLFLELGLYHCLNAIVCLFLELAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A5A0</accession>
    <name>A0A3S1A5A0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline O-acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_001244</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.6" evidence="5"/>
    <dbReference type="EMBL" id="RQTK01000020">
        <property type="protein sequence ID" value="RUS91027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A5A0"/>
    <dbReference type="STRING" id="188477.A0A3S1A5A0"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004102">
        <property type="term" value="F:choline O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008292">
        <property type="term" value="P:acetylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007274">
        <property type="term" value="P:neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF14">
        <property type="entry name" value="CHOLINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00439">
        <property type="entry name" value="ACYLTRANSF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0530">Neurotransmitter biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="10">
        <location>
            <begin position="122"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="43"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS91027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="726" mass="81661" checksum="0F99CB0F641765A4" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A9M6</accession>
    <name>A0A3S1A9M6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_006004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000146">
        <property type="protein sequence ID" value="RUS86209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A9M6"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018593518" description="Secreted protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS86209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="114" mass="11314" checksum="CE2202F85BE98E07" modified="2019-04-10" version="1">MKLQLMTVMMALTGALSMMHGGGFGGGGWGGGLVVSRREADDSSPPDDVADVADVAEDAETPTVAALSLLVDALLTGAKDSITIDAMGVAIQRTADGIVDAQGGEGTVVVVGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AB15</accession>
    <name>A0A3S1AB15_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sin3 histone deacetylase corepressor complex component SDS3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_005099</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000118">
        <property type="protein sequence ID" value="RUS87167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AB15"/>
    <dbReference type="STRING" id="188477.A0A3S1AB15"/>
    <dbReference type="OrthoDB" id="70376at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013907">
        <property type="entry name" value="Sds3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21964">
        <property type="entry name" value="BREAST CANCER METASTASIS-SUPPRESSOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08598">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01401">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS87167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="33276" checksum="7C4331C730420ECC" modified="2019-04-10" version="1">MSASINSRNEDYDGAESSDLDEEKDDEQASDEDTADASETEEKPKNSHVGVSVQRTEIKEQMYQDKLAQIKKQIGMLKEGSLPEFLRRTKKIELQYRERLRQNEIDKTVEIERADRNYQTNCSNALKEFEEKKVDMKDSLISDLKEKRNMIEMERQTMDLNGADFMEVKPTMTRKLRRRPNDPIPIPEKRRKPSPAQVNLLLDDGHIMDDLRVMLKVSGKPVAKKQMLPSHTSMVESSSDVRIEDGRLWYDKKWYQRNSMVQVENKEGGPRIYGTITNIGNQEVKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1ACD8</accession>
    <name>A0A3S1ACD8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_004012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000089">
        <property type="protein sequence ID" value="RUS88246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1ACD8"/>
    <dbReference type="OrthoDB" id="6151129at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.110">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018567330" evidence="1">
        <location>
            <begin position="29"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS88246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="211" mass="22927" checksum="0D18B4DE4C7A03F8" modified="2019-04-10" version="1">MFIDSERTTMLTIGLLLTVAALVTPGSARHFQVIDPESNLPCVLLDVSFNIKVTALKDGDVAMVRYLTPDDTGVRALGECINGTSEITVNFGESSMWALAFQPYKSHPVAVYRVFQFIPKEIFGSTVYLTDLVGFSAPKPIYLGNASHSYRCDAEDVSEYLQYTPALSGYTFKATVTVFDIHTQGMGLTDSGQFGPAEICPAPVPGRLPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1ARL4</accession>
    <name>A0A3S1ARL4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_022126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001489">
        <property type="protein sequence ID" value="RUS70112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1ARL4"/>
    <dbReference type="STRING" id="188477.A0A3S1ARL4"/>
    <dbReference type="OrthoDB" id="77878at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017171">
        <property type="term" value="F:serine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008547">
        <property type="entry name" value="DUF829_TMEM53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20908">
        <property type="entry name" value="LD15586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20908:SF1">
        <property type="entry name" value="LD15586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05705">
        <property type="entry name" value="DUF829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS70112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="340" mass="39525" checksum="7A4FDA88FD7BD443" modified="2019-04-10" version="1">MALVGGLTKGQFERLAVTLFPSQVFLRNRLSFETKHSKPMSDSIPKVNHSRLSERCHLVQAPERESWPWPVNPTKVLVVMLTWLGAKDRHILRYSHLYTKQGLDVLIVKSEAKDFIWPRNSIALAEQVHNVLENQMKEYNHIISHSMSVGSFNWTVIRRYLKQKENAEHICQKFKGQIYDSVVAGAGKGGLLDESPAEGRPEVHALDRMVHGIVVSRKLGPKMQWMIESLTKAYFSVTKRSTVRFYEKALKYFREEPLHIPTLFLTSRDDPMCDASVLERLVDIWEEEHNFKVSIKVWDNSPHAQHYLHHQEEYESLQQELFKEIFMSKESPAHRVKSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1ASL7</accession>
    <name>A0A3S1ASL7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_021275</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001295">
        <property type="protein sequence ID" value="RUS70965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1ASL7"/>
    <dbReference type="STRING" id="188477.A0A3S1ASL7"/>
    <dbReference type="OrthoDB" id="5806726at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24134:SF9">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24134">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN DDB_G0279043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="80"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="113"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="146"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="312"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS70965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="505" mass="54879" checksum="D6D271F396EF2E85" modified="2019-04-10" version="1">MASADHYEMLTHAVLNQDWEKLDHLMLKIPEGKRKTMLANQLLVQALDKENRRTIEKLLAHGAEINAHIDVVDFGPFDLSGLTPLELAIIRRKMVALSVLIGLGADVNLADHDGQTPLHLACSTVYFPVEGVRKLLEAGADCNKGCLQTPLQAASAIGRPDVVKLLLEHGADVHQTDADGNTCVALALKSKMHVAAASGSLPARLFSTTPTSDIVRKGKISCAKILLDAGSDINVVNNQGASILYSIINTNLADKDLLSYLLSRGANPDVGHICSGVTPIMSVARSPLKLKREELMHVLLEHGAIINKADMNGNTALHYAATNADPKAITFLLDNGADAYALNDKKASFMDTLSHDMYLDFLPTLLGKGVYPCRIAVQRGTNFDSFITQCESHLPPTPLSLAMFFGYTELAMRLKDLGFLTGEDVRWLAGESRIRAKLSPHAVQTYDNLITGVCSLTLMSFVRISDLLGATSDRASKVKQLRLPTFLQERLLFKRVSPLGQSSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AUF3</accession>
    <name>A0A3S1AUF3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_023669</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01002308">
        <property type="protein sequence ID" value="RUS68566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AUF3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS68566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="532" mass="58602" checksum="386422C38BA0EB53" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AXQ0</accession>
    <name>A0A3S1AXQ0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_017270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000782">
        <property type="protein sequence ID" value="RUS74957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AXQ0"/>
    <dbReference type="STRING" id="188477.A0A3S1AXQ0"/>
    <dbReference type="OrthoDB" id="6262013at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="248"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS74957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="268" mass="30599" checksum="270805114CDAD9B1" modified="2019-04-10" version="1">MADTPAAPAVSHVVVMERERRISKFYGDDPAMAPEFEEEIRRAWAAMPSSSAAHRLDVLLGNVGPTVRAELRCQPAEVQEDPERALAAILEVFGERRTPAQLLQNLLTLRQLPPESVRAFSHRCQSAYLMLVKRQESIGEAPYPDRLLRDHFLSNLRDVTLSRFLRDSLHQSPELTFRQIRESAIRWADDGAEQQPVHVAPITASATPGPTSQTREDRLELALTTILEKMDRLLDQRGPQRRREERLCYSCRKPGHFKRDCPDRHPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B2T5</accession>
    <name>A0A3S1B2T5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_017491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000803">
        <property type="protein sequence ID" value="RUS74740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B2T5"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS74740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="224" mass="24284" checksum="29C01A06BC6939EA" modified="2019-04-10" version="1">MKDMVEERAKRGENVIGGMHIGKKEGEELHVKAKDTVQWKSKTSTHIHYWLPWLVAGVDLNDLRRSGPNKRSVLVAGGWKTPITINLLQCEKSPGSWNGFLGCWMRKGVAIGGLSWAGSRLVCTLYTAGMLRIDASGGAGGGSRNGRSLPITGRDLDRPKWSPDTPISPDVNLNKPRHSHGHSDSVGSHPVAIYRENLTERAHGSNTSVVLVVLVNPGVIAICT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B697</accession>
    <name>A0A3S1B697_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_019132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000976">
        <property type="protein sequence ID" value="RUS73110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B697"/>
    <dbReference type="OrthoDB" id="10067251at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS73110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="418" mass="45558" checksum="DB092CEC24FB0734" modified="2019-04-10" version="1">MHGNRPHFLLEAVQVPFELSPISFVCSEYVDSLTLPAASYSQIPGVSLGGGCLRNKTPRHPSPVHVSEHPSPTQRDSDIVGEDGPAADPSTTRITTSRHPSADQQPSTGTPVTTNTAGTSTCTSINITAPHINKPSSSSSDHDATTTKHTHPLVTVTSHTYPHATTTTPTHSRSPTPARRTRPNRRFIKHDKYQLLKQQRSSINEHTVINLSSHTLTSTQTQLLSKNLNFCPTPKTINNIELSRDIFRFTRRLRLAEFFWDEENDEPNTTTCDTDTASPPFLLRHVSTVVNPGDNADGSFDNGNKDSSYTEVLKTTVHTGSNRNTPNDKDTRLVVDRQSAGGVKMLRPAVTDLLVMVTNELHTDPGAESHRCRPRLNTAPGGGTSHPSDTDPSPTWRVTAPNVTALGPGNEYVQGDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B703</accession>
    <name>A0A3S1B703_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_018618</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000917">
        <property type="protein sequence ID" value="RUS73612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B703"/>
    <dbReference type="STRING" id="188477.A0A3S1B703"/>
    <dbReference type="OrthoDB" id="6161578at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061564">
        <property type="term" value="P:axon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007423">
        <property type="term" value="P:sensory organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11430">
        <property type="entry name" value="bHLH_TS_ATOH1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000025">
        <property type="entry name" value="protein atonal homolog 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050359">
        <property type="entry name" value="bHLH_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290:SF162">
        <property type="entry name" value="TRANSCRIPTION FACTOR ATOH7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="4" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="9">
        <location>
            <begin position="219"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="40"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="145"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS73612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="285" mass="31655" checksum="E5EBEA192847AE11" modified="2019-04-10" version="1" fragment="single">DKAGDDIASYLSPYSPLAMSSPSTLSFSEDLASFETSFRATVDNPPSDSDATPNTPLTPYRGSSRQHFLFPDVSEVSPSDQLHPPQQQSLTLYHQKTMNSPTQHHHHHQQHQQQNPLVFQQQYDYQPQRSFNKNIQAKPLLSLRVGGSSASDGYSSSDSGAPELDSFDSEITSDNHDRKKPEGQKTSTKKTSSLQFGKKSVSGGVTSHAPASPGEIQKKRRLAANARERKRMRSLNTAFDRLRQVIPSAGEDQELSKYDTLQMAQTYINTLRELLDEHPIDVSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B775</accession>
    <name>A0A3S1B775_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_015558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000644">
        <property type="protein sequence ID" value="RUS76668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B775"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS76668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="374" mass="38826" checksum="FF6703EC1ACC11AE" modified="2019-04-10" version="1" fragment="single">STVSSSGQSNLPPPSASSSSLSTTPVPPPAEDGKSGVGTSTADGTGNKLSSASLPPSDTSTVSAGTSSSGAQLQPAVSVSHPQHPSMLMSGQQSQSESHPQHPSMLMSGQQSQSESHPQHPSMLMSGQQSQSESHPQHPSMLMSGQQSQSESHPQHPSMLMSGQQSQSESHPQHPSMLMSGQQSQSASHPQHNPPPGWGPSAPPGMPHYPQYPGPPNMGAWRAMMQPGAYPGQPQHHQHHQHHQQHPGFHPGYDRMPGYGLQYPPPPPPSSAQQGHPSPGKTEGSPSSAAPKAKKAKTQKKSVSASGASGGKDGSSSAGARGKGSKATGKGRGRGAFMIDDLIHGEEDGVNAEDINDIASYVATDEYFKQQTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BAL1</accession>
    <name>A0A3S1BAL1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Anaphase-promoting complex subunit 4 WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_008441</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000230">
        <property type="protein sequence ID" value="RUS83783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BAL1"/>
    <dbReference type="STRING" id="188477.A0A3S1BAL1"/>
    <dbReference type="OrthoDB" id="4869960at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045717">
        <property type="term" value="P:negative regulation of fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF40">
        <property type="entry name" value="WD AND TETRATRICOPEPTIDE REPEATS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="40"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="83"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="574"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="604"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="322"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="522"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="683"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="340"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="364"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="528"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS83783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="706" mass="78710" checksum="A2EEC88ABAAE9D89" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BFW7</accession>
    <name>A0A3S1BFW7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Zinc finger Sec23/Sec24-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">EGW08_012381</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">EC2010</strain>
            <tissue evidence="21">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000424">
        <property type="protein sequence ID" value="RUS79855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S1BFW7"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01479">
        <property type="entry name" value="Sec24-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.380:FF:000004">
        <property type="entry name" value="SEC24 homolog B, COPII coat complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000019">
        <property type="entry name" value="SEC24 homolog B, COPII coat complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041742">
        <property type="entry name" value="Sec24-like_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF39">
        <property type="entry name" value="SECRETORY 24AB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="17">
        <location>
            <begin position="769"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="18">
        <location>
            <begin position="842"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="20">
        <location>
            <begin position="1084"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="19">
        <location>
            <begin position="1179"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="363"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="379"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="397"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="531"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="630"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="655"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RUS79855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="23">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1435" mass="152834" checksum="CE81D1A9E19FDE5A" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BJJ5</accession>
    <name>A0A3S1BJJ5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_002409</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000047">
        <property type="protein sequence ID" value="RUS89797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BJJ5"/>
    <dbReference type="OrthoDB" id="10059415at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026079">
        <property type="entry name" value="CDR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19232">
        <property type="entry name" value="CENTROCORTIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19232:SF7">
        <property type="entry name" value="CENTROCORTIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="248"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="10"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="199"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="251"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="265"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS89797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="309" mass="35425" checksum="EFECC1082A4DB2D9" modified="2019-04-10" version="1">MQDTMSSYDLQLAAELGKALLEKNRELEAQVTSLQNTSQEQSMEIQYLKSQLDTMRTMSESRNRIYEEVDRTAQDMEKTNQKLTMEARADKQKIDKQASLVKQLEDKVDDLQKKLDDFKAAEKKVAKKAPEKRRTSSLNRLSLSDSKHGDQGYYFENLAWTNTDHFKNIPLNPYEFEIRKLQDSIQHLKVQQTIDRRKLEDADVEITVLAEENSSLEKKINVLEAKLSEAIIVQYELEREKAELRQRARMRSGATASASGTVTADMHEELTEGESRLLDEMEHDDPEIRSEAKAVKLETGGSLYSSTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BJW0</accession>
    <name>A0A3S1BJW0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_023278</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the citrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001903">
        <property type="protein sequence ID" value="RUS68959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BJW0"/>
    <dbReference type="STRING" id="188477.A0A3S1BJW0"/>
    <dbReference type="OrthoDB" id="6361676at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046912">
        <property type="term" value="F:acyltransferase activity, acyl groups converted into alkyl on transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42871">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42871:SF1">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS68959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="298" mass="32764" checksum="19B49A28D0B0622C" modified="2019-04-10" version="1">MNSLIAGVNILAAENVAAGKKETQKDVATNIIAKIATMTAMAYRHNNGLKFLEPKKEFNYTENFLYMMFAEDENYKPDTLYVKAMDTIFMLHADHEQNASTSTVRLSGSTGCSPYAAIIAGLTALSGPAHGGANEAVLKMLSQIGEVANIEKFVAKAKDKDDSFRLMGFGHRVYKNTDPRATAMKQNCEAILAKMGDSDNPSLEIAKKLEEIALQDSYFIDRKLFPNVDFYSGIILKAMGIPEEMFTAIFALARTSGWISQWIEMMNDPAQKIEPNASTIAASRAADGLLLFGDKQFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BP72</accession>
    <name>A0A3S1BP72_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_003962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000088">
        <property type="protein sequence ID" value="RUS88260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BP72"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS88260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="305" mass="35596" checksum="B543512FACB33D72" modified="2019-04-10" version="1">MPFRLDDELLEVEISGGETGPALGGTNHSKKKVEPKPEDTKTINNRYHNHHHRHHHHHHHHHHHHHNNKNNNTTTTTKKKEKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKNKNKNNNKNSNNIYNTNISKLLHDMTLPMQQTMSIAFLAAILSAASPMPVRMKAAAKTDAPVTTPVSAAVRCRDLRNTAMNGMTAPHADESNRRCVLTRSRIVLHLRRLKEDWLPIGSVRFLSIVMSLPLSSSLTEARIIRIPRETKGTLSLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BQL6</accession>
    <name>A0A3S1BQL6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_003145</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000066">
        <property type="protein sequence ID" value="RUS89082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BQL6"/>
    <dbReference type="STRING" id="188477.A0A3S1BQL6"/>
    <dbReference type="OrthoDB" id="1630758at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043122">
        <property type="term" value="P:regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013010">
        <property type="entry name" value="Znf_SIAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF157">
        <property type="entry name" value="RECEPTOR-ASSOCIATED FACTOR, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51081">
        <property type="entry name" value="ZF_SIAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="18"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="SIAH-type" evidence="6">
        <location>
            <begin position="95"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS89082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="15969" checksum="66D0908E73A79914" modified="2019-04-10" version="1" fragment="single">MGYSLLRFVRPVDQHLRCPICSHVLESPVLTQCGHTFCRTCLLTWLAQSGVSASWPGPPDRDLHDDHSGTCPECRSMVSVGELSQVICLRNLILSLEVTCENSDRGCPAHFPLERNEVHLQTCGHAPVSCCGCQGMINRAELTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BSG6</accession>
    <name>A0A3S1BSG6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein FAM219A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_002019</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM219 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000037">
        <property type="protein sequence ID" value="RUS90238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BSG6"/>
    <dbReference type="STRING" id="188477.A0A3S1BSG6"/>
    <dbReference type="OrthoDB" id="6119141at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029339">
        <property type="entry name" value="FAM219"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31281">
        <property type="entry name" value="PROTEIN FAM219A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31281:SF3">
        <property type="entry name" value="PROTEIN FAM219A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15260">
        <property type="entry name" value="FAM219A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS90238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="19539" checksum="2FBC6F830AA9257C" modified="2019-04-10" version="1">MEDSGIDSDQQKSHPLTQEVPNGHQTESSKITPYSALKKTSELQKKIERQRDKARKSSTSSVEHQPKKNFVARSRLTVPVHTTSRVTQKDKDLSASSADQQPLVAIVSDESEEDEFDVPRLPKAAHKEITEQLIKDGYNLDLEPDDEDLDLIPPRPLSERCSCCNLPNRCYIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BWV5</accession>
    <name>A0A3S1BWV5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Galactosyltransferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EGW08_001485</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">EC2010</strain>
            <tissue evidence="15">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000025">
        <property type="protein sequence ID" value="RUS90774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BWV5"/>
    <dbReference type="STRING" id="188477.A0A3S1BWV5"/>
    <dbReference type="OrthoDB" id="10016069at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008378">
        <property type="term" value="F:galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033842">
        <property type="term" value="F:N-acetyl-beta-glucosaminyl-derivative 4-beta-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006688">
        <property type="term" value="P:glycosphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00899">
        <property type="entry name" value="b4GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003859">
        <property type="entry name" value="Galactosyl_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027791">
        <property type="entry name" value="Galactosyl_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027995">
        <property type="entry name" value="Galactosyl_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300:SF46">
        <property type="entry name" value="BETA-1,4-N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02709">
        <property type="entry name" value="Glyco_transf_7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13733">
        <property type="entry name" value="Glyco_transf_7N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02050">
        <property type="entry name" value="B14GALTRFASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="535"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase N-terminal" evidence="14">
        <location>
            <begin position="640"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase C-terminal" evidence="13">
        <location>
            <begin position="778"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="87"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="248"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="333"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="498"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="606"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="15"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="251"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="339"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="610"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RUS90774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="907" mass="99485" checksum="D718EADC172EDD35" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BY49</accession>
    <name>A0A3S1BY49_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase-like protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_000493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000006">
        <property type="protein sequence ID" value="RUS91785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BY49"/>
    <dbReference type="STRING" id="188477.A0A3S1BY49"/>
    <dbReference type="OrthoDB" id="199041at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106370">
        <property type="term" value="F:protein-L-histidine N-pros-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007884">
        <property type="entry name" value="METL9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12890">
        <property type="entry name" value="DREV PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12890:SF0">
        <property type="entry name" value="PROTEIN-L-HISTIDINE N-PROS-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05219">
        <property type="entry name" value="DREV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS91785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="41504" checksum="AA6ADA3C72D36903" modified="2019-04-10" version="1">MTCQVSSTNKADFKYETFTFCLSLLVLLIRVTFGQETVDKEELQSQFKMSDDNSMDSRFTAPRAVAQPYIRSSLARAVYYKFKEDEQNQNDRHVYWYRAILSRLSQDLCGKFVQFDQDDGADEFLQNCQEKSDAILSQIFYSLARPILNVFMTQTSINGLLRRGSMYIFSKPQFEQLMNYTAYHKQGNLLDLGAGDGMVTAQMSSYFNQTYATEMSGVMARKLSSMGYHVLDVDQWAESGLKFDVVSCLNLLDRCDKPMSLLAQIRKVLSPDTGRLLVATVIPFKPYVEFNSKTHEPSEFLRVTGSNFEEQVDQLVSIFRQAGFVVEKFTRLPYLCEGDLRHSFYVLTDALFVLKAAEETTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BZS8</accession>
    <name>A0A3S1BZS8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sex-regulated protein janus-B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_013154</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">JanA and janB regulate somatic sex differentiation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the janus family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000471">
        <property type="protein sequence ID" value="RUS79101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BZS8"/>
    <dbReference type="STRING" id="188477.A0A3S1BZS8"/>
    <dbReference type="OrthoDB" id="10249612at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101006">
        <property type="term" value="F:protein histidine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007548">
        <property type="term" value="P:sex differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.20.20:FF:000002">
        <property type="entry name" value="Sex-regulated protein janus-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.20.20">
        <property type="entry name" value="Janus/Ocnus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007702">
        <property type="entry name" value="Janus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038596">
        <property type="entry name" value="Janus_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12258:SF5">
        <property type="entry name" value="BCDNA.GH02250-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12258">
        <property type="entry name" value="JANUS-A/JANUS-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05005">
        <property type="entry name" value="Ocnus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143724">
        <property type="entry name" value="PHP14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0726">Sexual differentiation</keyword>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00068496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR607702-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR607702-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS79101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="135" mass="15358" checksum="FF102A2C26CB699F" modified="2019-04-10" version="1">MASRSSQTASATSYKNPKLRDIPEVEIDKNGKFKYILIKVHDPDVDREFKHIVRGTSKASIHEEIFDMCVNQIEEKGLDCEVLGGGSIDHEPSKKAIKIYGYSKQYGQADHSIAHSLLLKKFKDYDHVTWNNDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H7M3</accession>
    <name>A0A3S1H7M3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_018401</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000895">
        <property type="protein sequence ID" value="RUS73833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H7M3"/>
    <dbReference type="STRING" id="188477.A0A3S1H7M3"/>
    <dbReference type="OrthoDB" id="7464992at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="2">
        <location>
            <begin position="59"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="403"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS73833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="471" mass="52235" checksum="86D4A940E9E63BAB" modified="2019-04-10" version="1">MDPIQQLLFFFSFQHNIEKKQADASKKPKGSRTVKPVYDPFKLVPCLPFSEENTAPYEIEMFSTALAIMDIHAHISKTEVIGMLGGQFCSQRHRLTVSMAVPCKSMSTGMQCEMDPVSQTLASEQIEDVGMQVVGWYHSHPTFSPDPSVRDIETQQKFQYWFSKGGNHFVGVIISPYNTLSPSVNSDIRCLTISEFHSKEFLCNIPYKFAYDIVYRDNLREILGPASELAEKYSNYVNRVMLSCQYRSSLGITCLSKMLQSVKRLLVPEDQENSLPSEGHTSSKSVSACGPLVRANTAELLKPLLSKVQNGSVGHVSKGLNHQSASSEAFMNHKNTEKNDSPARTNSSSSHTSVSHSPSSFHKSLDLERSKMTCLTVDTMTFPDHLPPSRSNFITTSEQQRLSSSTAAASTTVASSSSVNKSKVDEVMHWLEQIFLEKFTQGTPRSPPIGTLSSLERAKPRSPQASMSSAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HCF5</accession>
    <name>A0A3S1HCF5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_015714</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000656">
        <property type="protein sequence ID" value="RUS76521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HCF5"/>
    <dbReference type="STRING" id="188477.A0A3S1HCF5"/>
    <dbReference type="OrthoDB" id="6155778at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005154">
        <property type="term" value="F:epidermal growth factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007173">
        <property type="term" value="P:epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045840">
        <property type="term" value="P:positive regulation of mitotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10740:SF14">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10740">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018543271" description="EGF-like domain-containing protein" evidence="9">
        <location>
            <begin position="23"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="156"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="277"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="388"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="475"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="325"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="427"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="370"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="427"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="397"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="485"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS76521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="57144" checksum="436AF1068606C412" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HCP7</accession>
    <name>A0A3S1HCP7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_015563</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000644">
        <property type="protein sequence ID" value="RUS76673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HCP7"/>
    <dbReference type="STRING" id="188477.A0A3S1HCP7"/>
    <dbReference type="OrthoDB" id="9449012at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000010">
        <property type="entry name" value="Integrator complex subunit 6 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057413">
        <property type="entry name" value="Beta-barrel_INTS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029307">
        <property type="entry name" value="INT_SG_DDX_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051113">
        <property type="entry name" value="Integrator_subunit6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12957">
        <property type="entry name" value="DEAD/H BOX POLYPEPTIDE 26/DICE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12957:SF2">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25462">
        <property type="entry name" value="Beta-barrel_INTS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15300">
        <property type="entry name" value="INT_SG_DDX_CT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="48"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="713"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="817"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="761"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="817"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS76673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="990" mass="111432" checksum="501FDD88C946C474" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HH18</accession>
    <name>A0A3S1HH18_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_013031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000464">
        <property type="protein sequence ID" value="RUS79202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HH18"/>
    <dbReference type="OrthoDB" id="6210183at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS79202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="422" mass="47818" checksum="FC8F1795884F2BEE" modified="2019-04-10" version="1">MLRKDFEEMKQTVTETQKLRKDFEEMKQTVTETQKLRKDVEDMKQSHSETQKLRKDVEDMKQSHSETKKLRKDVEDMKQSHSETKKLRKDVREMKQSFTEKLSDSHRSLSKKINSNEKKINKLNEASETNTQQIWGLRKLQKLFHNMTMTTQTAAAAAAATATSPSDQASASTAATARRAPTSLRQRSTFSATSSGDSKTPWISDMKLLPGGLVLLADNNNHLVKLYDLQVRTSLFIPGIWDMKLLPGGLVLLADWTNQLVKLYDLQVRTSLFIPGIWDMKLLPGGLVLLADWTNNLVKLYDLQVRTSLFIPGIWDMKLLPGGLVLLADYQSTCKAVRPAGPPYRQPGVGRVSFVHGSGGHQVPVWLGCGRHPVWSTTYGNFIRHTGQCGCQEHDPDHQEVRRYSRSHRSNPGCGLLDRSWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HKL2</accession>
    <name>A0A3S1HKL2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">vitamin-K-epoxide reductase (warfarin-sensitive)</fullName>
            <ecNumber evidence="3">1.17.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_010814</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VKOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.4" evidence="3"/>
    <dbReference type="EMBL" id="RQTK01000338">
        <property type="protein sequence ID" value="RUS81430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HKL2"/>
    <dbReference type="STRING" id="188477.A0A3S1HKL2"/>
    <dbReference type="OrthoDB" id="17010at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047057">
        <property type="term" value="F:vitamin-K-epoxide reductase (warfarin-sensitive) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042373">
        <property type="term" value="P:vitamin K metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12917">
        <property type="entry name" value="VKOR_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.130">
        <property type="entry name" value="VKOR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012932">
        <property type="entry name" value="VKOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038354">
        <property type="entry name" value="VKOR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042406">
        <property type="entry name" value="VKORC1/VKORC1L1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14519:SF5">
        <property type="entry name" value="VITAMIN K EPOXIDE REDUCTASE COMPLEX SUBUNIT 1-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14519">
        <property type="entry name" value="VITAMIN K EPOXIDE REDUCTASE COMPLEX, SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07884">
        <property type="entry name" value="VKOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00756">
        <property type="entry name" value="VKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Vitamin K epoxide reductase" evidence="13">
        <location>
            <begin position="9"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS81430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="167" mass="18953" checksum="BD42DF55D9B2EF30" modified="2019-04-10" version="1">MMSAELGYLVWSNSADVVLFNLIGVIICVYSLYIEIKKEKDPKYRAACDFNEHMSCSRVLTSKYSHGFGIAEGLLGKKHILNSRNCNMGLVMYLANLVIFFTLWEPLSSSIMLFCAASSIFVCIYLAAILAFVLKDLCVVCITTYIINGCLVYLNYQRYSHPYLLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HZK3</accession>
    <name>A0A3S1HZK3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_002908</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000059">
        <property type="protein sequence ID" value="RUS89301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HZK3"/>
    <dbReference type="STRING" id="188477.A0A3S1HZK3"/>
    <dbReference type="OrthoDB" id="28230at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001512">
        <property type="entry name" value="Receptor tyrosine-protein kinase erbB-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="7"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="12">
        <location>
            <begin position="357"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS89301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="57790" checksum="D0D003DC2448F075" modified="2019-04-10" version="1" fragment="single">EFPRERLKLLEVIGKGKFGQVWSAEVLNIIGTGQWELVAVKMCKETSTDVEKMDFLNEVALVSEIPKHLNVVNYLGCCTAIEPSLLIMEYITGGDLLRFLRKHRKFDLYADQPNVDTRSELILSAETAEVRHANTANWAKMAREMSFVNLSFQPDDLSMEVCLKHRITLQIIHRDLAARNVLVSDRGVCKITDFGLARSTDESDTYERTSKGALPIRWMSPEALTDGCYSSKSDVWAYGVLLWEIVTLGASPYPGLSARDVFRFVNSGSTMDRPDHCSSDLYKLMKECWAYKPQQRLDFVHVCCCLEELLEREEDYIMLDQFQSEHYTYIDPLQLDEKLMFKRHRVVGFVQLGSVRKCLYFTHTKLDWHSAARSCANIGARLYTARSERELLHEIDIPYASRHEDYWIGLNDIETEGNFQWGQDSEVTLINEVKEHPEAFYPWKQGQPDDLEEKDCVLKGRDGLWTVEQCNKQYRFICEEMAASELKQLREFRKSIIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2024-03-27" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1I449</accession>
    <name>A0A3S1I449_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_000414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000005">
        <property type="protein sequence ID" value="RUS91843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1I449"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018629162" evidence="1">
        <location>
            <begin position="18"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS91843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="230" mass="21028" checksum="54A8C503E24C0DEB" modified="2019-04-10" version="1">MASFLIVACALVASALAGDIYGDGYGYGFGGRGVGYGKGGFGGKGVLGGAYGYDGKGYGVGGLGYGKGGFGAGYDGIGYGKGGFGAGYGKGGIGAGYGGIGYGKGGYGAGYGDLGYGGIGYGKGGIGAGYGGIGYGKGGFGAGYDGIGYGKGGFGAGYGKGGIAAGYGGIGYGKGGIGAGYGGIGYGKDGFGAGYGGIGYGKGGFGAGLGYGAGVGGFGYGGYGKGKGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SIH1</accession>
    <name>A0A433SIH1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_023483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01002037">
        <property type="protein sequence ID" value="RUS68753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SIH1"/>
    <dbReference type="STRING" id="188477.A0A433SIH1"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS68753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="104" mass="11712" checksum="B57485F7C7B0D022" modified="2019-05-08" version="1" fragment="single">MKFDDILAQQTGEFGPYQARVYVLACLPLLTQAIMSILPVFTLASLRHRCAIPGLPNDTYAVQSERHQQLINASIPWEKDGDGWARSSCYMYRPGNNITWGPQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SMX8</accession>
    <name>A0A433SMX8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_021695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001384">
        <property type="protein sequence ID" value="RUS70542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SMX8"/>
    <dbReference type="OrthoDB" id="6078448at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="710"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="844"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="589"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS70542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="867" mass="95667" checksum="A371AD3CE9BF40EC" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SNQ1</accession>
    <name>A0A433SNQ1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_021461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001335">
        <property type="protein sequence ID" value="RUS70782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SNQ1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS70782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="122" mass="12221" checksum="F60284D03877CC44" modified="2019-05-08" version="1" fragment="single">CGPVSHSSNLCGHVSHSDDSCGPVSHSSNLCGHVSHSDDSCGPVSHSSNLCGHVSHSDDSCGPVSHSSNLCGHVSHSDDSCGPVSHSSNLCGHVSHSDDSCGPVSHSSNLCGHVSHSDDSCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SPN0</accession>
    <name>A0A433SPN0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box/LRR-repeat protein 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">F-box and leucine-rich repeat protein 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_021038</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001257">
        <property type="protein sequence ID" value="RUS71202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SPN0"/>
    <dbReference type="STRING" id="188477.A0A433SPN0"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000005">
        <property type="entry name" value="F-box/LRR-repeat protein 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000260">
        <property type="entry name" value="F-box/LRR-repeat protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20872">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20872:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="10"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00070268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00077971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS71202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="391" mass="45106" checksum="8A482FBC609B8CAC" modified="2019-05-08" version="1">MIEETGELSNDAWASLPDTILTQIFAHLNVVDRCKASCVCRHWLHCVEIPLLWRKFNCGFFFPSERNVINCLKRYGCHVKELSIELNQYEKENRSNAVAIIDHLASLKEPKLTHLTISFRGENPLFYAGQEFTSSLIRLFQTIGKSDHYSLTHVNLRELESNFTDEFVNSLSNCKNLKYLNLLNKVLVCNISADSIVTLITKCTKLKILHVYHSSVSNSVLHAFAQSDREPLLRLGIVCRRQEKYGEDLTPSAWLDLLTRSPHLKVELGFDHTCPLHRVSEIMKPEIPVQELHLVTFSRIYPEVRMAASYYKDTLVKLVVQTRPSRELEEALLEVAQRCFLLHTLYVFCIVRKEIVDQILELCPTMKMKKTYILKSVIEPEPWTVGQEEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SR33</accession>
    <name>A0A433SR33_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_020517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001170">
        <property type="protein sequence ID" value="RUS71720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SR33"/>
    <dbReference type="STRING" id="188477.A0A433SR33"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052907">
        <property type="entry name" value="Beta-lactamase/esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43319">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43319:SF3">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="30"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS71720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="427" mass="48261" checksum="CE4239A961BAF5DB" modified="2019-05-08" version="1">MMNKLKFPEPTGFVAPGFERVLHVFRDNYKSGLETGSSFAAYYKGEPVVNIWGGLADWQVKSAWKEDTMGLFHSTTKFMAALTIAHLVERDALNYGEKISKYWPEFAQNGKENITLEQLLSCQAGLAALSDNFYLKWIKDDPQRLHNLLARQKPLWSPGTAHGYHPITMGLYLNEIVKKVDKKGRTLSQYFQDEIAKPFGIEFYIGLPKSLYHRVTRLEPMKVDIKKLAEILNNFQGDAELYRLAFSQPQDWFSTRILNDADFLELPISSSHGVGTALAVAKLMGIIANGGQHEGKVMLRPESINGLQMPLSHGTDLTLGNSQVYGRGTMLIPIVAGEKSWFMFGHTGYGEQIGAADSHYRTGFAYTTNRVYPSMDQLGMEIKWKSLATVLFQCIHEFEGVQIERMMLDTVEELEKNKRVLAQKCKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SSV0</accession>
    <name>A0A433SSV0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enkurin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_019894</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001078">
        <property type="protein sequence ID" value="RUS72336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SSV0"/>
    <dbReference type="STRING" id="188477.A0A433SSV0"/>
    <dbReference type="OrthoDB" id="10264920at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027012">
        <property type="entry name" value="Enkurin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052102">
        <property type="entry name" value="Enkurin_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21490:SF2">
        <property type="entry name" value="ENKURIN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21490">
        <property type="entry name" value="ENKURIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13864">
        <property type="entry name" value="Enkurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51665">
        <property type="entry name" value="ENKURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enkurin" evidence="7">
        <location>
            <begin position="163"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="49"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="150"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS72336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="258" mass="30004" checksum="E3E1B809EE236085" modified="2019-05-08" version="1">MRNNFDIGSKNQLHENVRRMREIQRRCKQKEEQKKEPVKILWKSEKYSNAESKIKQDVHKPQTPRPGSANFLRAHSRAGPPVKLESRPCTPEVSELSVPLASSAGDVKLVRNNFDFIKVNGINARRSATQRPPSAASIDNYKRRQEELLSHHQFGEVPNYLRKRNQSWREEQEERGRNTPDPAMPPNHRQLPETERTETLNLLTQKQTDVIGQIQRLPIGADTMRVRQHRQSLEKQLGEIEEAIKIFSRPKVFVRVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433STM1</accession>
    <name>A0A433STM1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_019611</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001041">
        <property type="protein sequence ID" value="RUS72637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433STM1"/>
    <dbReference type="STRING" id="188477.A0A433STM1"/>
    <dbReference type="OrthoDB" id="5859791at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019478672" evidence="2">
        <location>
            <begin position="21"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS72637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="105" mass="11816" checksum="FC9E3501E0817810" modified="2019-05-08" version="1" fragment="single">FLFCCFPLFISVFQLETFFALPRKERKFVPRDPKQTQALLDLEKVFGDGSKPQQPDPPAGTGKPKSEPEASADKKSQAIGQEIPDTTLLIHFFGRNGKDVLKYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SWB5</accession>
    <name>A0A433SWB5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_018639</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000919">
        <property type="protein sequence ID" value="RUS73596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SWB5"/>
    <dbReference type="STRING" id="188477.A0A433SWB5"/>
    <dbReference type="OrthoDB" id="10259809at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005113">
        <property type="term" value="F:patched binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005119">
        <property type="term" value="F:smoothened binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028784">
        <property type="entry name" value="BBS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032728">
        <property type="entry name" value="BBS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056419">
        <property type="entry name" value="GAE_BBS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20870">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20870:SF0">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14779">
        <property type="entry name" value="BBS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23304">
        <property type="entry name" value="GAE_BBS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bardet-Biedl syndrome 1 N-terminal" evidence="1">
        <location>
            <begin position="8"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Bardet-Biedl syndrome 1 protein GAE" evidence="2">
        <location>
            <begin position="471"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS73596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="578" mass="65282" checksum="191207698E6212F1" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SYP3</accession>
    <name>A0A433SYP3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_017796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000831">
        <property type="protein sequence ID" value="RUS74431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SYP3"/>
    <dbReference type="STRING" id="188477.A0A433SYP3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS74431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="222" mass="26541" checksum="0BFB07E8733FC30D" modified="2019-05-08" version="1" fragment="single">YYLGESVFIEYFLLQAMVKTNYYLGESVFIEYFLLQAMVKTNYYLGESVFIEYFLLQAMVKTNYYLGESVFIEYFLLQAMVKTNYYLGESMFIEYFLLQAVVKTNYYLGESVFIEYFLLQAMVKTNYYLGESVFIEYFLLQAMVKTNYYLGESVFIEYFLLQAMVKTNYYLGESVFIEVLLQAMVKTNYYLGESVFIEYFLLQAMVKTNYYLGESVFIEYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SZM6</accession>
    <name>A0A433SZM6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EIF-4F 25 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_017624</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000814">
        <property type="protein sequence ID" value="RUS74620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SZM6"/>
    <dbReference type="STRING" id="188477.A0A433SZM6"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000043">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF18">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E HOMOLOGOUS PROTEIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS74620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="24439" checksum="632ACCC1D454E7C2" modified="2019-05-08" version="1">MNNKFEALKAEDSGDDDDEAFRPAPKPGEGEHPLQYNYAIWFSRRSQGNKSMRYDQNLKFIASFASVEQFWNIHSYIVRPGDMSGHVDYHLFKEGIRPMWEDDANKHGGKWIIRLKKGLASRCWENLILAMLGEQFMVGEEICGAVISIRFQDDILSLWNRSNDQTITSRIRDTLQRVLNLPPNTIMEYKAHTDSLKDNTSFRNTDLFMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T1H8</accession>
    <name>A0A433T1H8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_016839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000745">
        <property type="protein sequence ID" value="RUS75400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T1H8"/>
    <dbReference type="OrthoDB" id="70874at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS75400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="250" mass="26329" checksum="FD3BFFA9F18EFD21" modified="2019-05-08" version="1">MAALCPLHSLLLDSFSGNTHTRFSGNSLDNILGNSPKSFYGKTLDNISGNTHNRFSGNSLDIILGNPLKSVSGKSFNSISGNPANRLSVSNLNTIAGNIFSSPSGNSLDMISGNSMNSLSGNLLDSSFGDNLKSFSGNSLHSPSGNTLDSLSGNTLDIISGNPMNRIPRYLLDSFSWNALESFSGNPLNSSSGNTLDRISGNPSSSDTNGRVIEDPLKRNSKSGPLMASFKLNQNYFTGVGSLRPSRLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T3S3</accession>
    <name>A0A433T3S3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">VWFD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_016035</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000681">
        <property type="protein sequence ID" value="RUS76191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T3S3"/>
    <dbReference type="STRING" id="188477.A0A433T3S3"/>
    <dbReference type="OrthoDB" id="6287323at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052749">
        <property type="entry name" value="Alpha-tectorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014853">
        <property type="entry name" value="VWF/SSPO/ZAN-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46160">
        <property type="entry name" value="ALPHA-TECTORIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46160:SF9">
        <property type="entry name" value="PROTEIN PRY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08742">
        <property type="entry name" value="C8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00832">
        <property type="entry name" value="C8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ShKT" evidence="4">
        <location>
            <begin position="69"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="3">
        <location>
            <begin position="176"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="69"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS76191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="537" mass="59881" checksum="E070519E428B6D61" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T4G6</accession>
    <name>A0A433T4G6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mpv17-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_015803</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000662">
        <property type="protein sequence ID" value="RUS76434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T4G6"/>
    <dbReference type="STRING" id="188477.A0A433T4G6"/>
    <dbReference type="OrthoDB" id="5345392at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061668">
        <property type="term" value="P:mitochondrial ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF8">
        <property type="entry name" value="MPV17-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS76434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="28503" checksum="7533678C9C872F6B" modified="2019-05-08" version="1">MHVLKRAALASQKLSIKVRPVVTSVRDGGKLLFSEKLLLYTNTGLSVAISIAGDVMQQNLKSFRLREGSGKKWDKTRTFHMAASGLAVGPVAHYWYLYLDRWFPGRNVASLFKKVALDQLVLSPVYVTMFLVVIGLLEGQSRISMKEEFKVTGVSMIVSDVVVWTPAQTFNFYFVPTRFRVLFDNCISFAMDMWYSYLRFDCHHLHSSSIKGSKTGCNSTGLNDSLHLDTNHAAIEPIDCTEYCQALLPTSSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T5S0</accession>
    <name>A0A433T5S0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial assembly of ribosomal large subunit protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_015389</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for normal mitochondrial ribosome function and mitochondrial translation. May play a role in ribosome biogenesis by preventing premature association of the 28S and 39S ribosomal subunits. Interacts with mitochondrial ribosomal protein uL14m (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits. Addition to isolated mitochondrial ribosomal subunits partially inhibits translation, probably by interfering with the association of the 28S and 39S ribosomal subunits and the formation of functional ribosomes. May also participate in the assembly and/or regulation of the stability of the large subunit of the mitochondrial ribosome. May function as a ribosomal silencing factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Iojap/RsfS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000629">
        <property type="protein sequence ID" value="RUS76856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T5S0"/>
    <dbReference type="STRING" id="188477.A0A433T5S0"/>
    <dbReference type="OrthoDB" id="21330at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090071">
        <property type="term" value="P:negative regulation of ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000018">
        <property type="entry name" value="Mitochondrial assembly of ribosomal large subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01477">
        <property type="entry name" value="Iojap_RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004394">
        <property type="entry name" value="Iojap/RsfS/C7orf30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00090">
        <property type="entry name" value="rsfS_iojap_ybeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043">
        <property type="entry name" value="IOJAP SUPERFAMILY ORTHOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043:SF0">
        <property type="entry name" value="MITOCHONDRIAL ASSEMBLY OF RIBOSOMAL LARGE SUBUNIT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02410">
        <property type="entry name" value="RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="123"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="398"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="148"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="403"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00053669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS76856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="433" mass="48849" checksum="CAAFA2BF4BFB29B2" modified="2019-05-08" version="1">MAPSSRLLKGATMQSIKCCSCFSLQTSHCVVQQFQNSRPDSYRFLSILYKLRKNTDPTKVERPTIRSYQSSRSRSVSQGVSRGQDHDNLSYSYLKNCRKSNCFSSGDYLSKLIVRSLSVSSKCATSSHDNDPEHQSTGTRSSGTKGTDGGEKKDKSILDNDPELKSIIEDIKRDFANEKPKNKTPETPSSHEKQSCESSILASEIDDNSRLEFTAEDQFEYDYSVAEDIEEYDYIDESESVQHQIQPEKDIPISLERGNSGVFELDELLLLLDRLGAENIVSFPVPPEAKFCDHMVVVSAKSRRHLQAINEEMLYIHKRKKSQSDNHLVVEGLNKSDWCAMDLGNIVLHVFYGKLREYYNIESLWILGPDKDPKCQEADQDPYALSAEDLFWLQAAKSKETSGSEQTDQELSSSGHVSDSHAGWGSSPRQSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T7N0</accession>
    <name>A0A433T7N0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_014647</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000569">
        <property type="protein sequence ID" value="RUS77589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T7N0"/>
    <dbReference type="STRING" id="188477.A0A433T7N0"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000891">
        <property type="entry name" value="ATP-binding cassette sub-family G member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF78">
        <property type="entry name" value="ABC TRANSPORTER EXPRESSED IN TRACHEA, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="486"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="515"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="594"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="622"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="705"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="48"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="13"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS77589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="735" mass="81474" checksum="E1D8589F7D24BD13" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T7W3</accession>
    <name>A0A433T7W3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_014576</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000561">
        <property type="protein sequence ID" value="RUS77679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T7W3"/>
    <dbReference type="OrthoDB" id="6091698at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050801">
        <property type="entry name" value="Ca-Dep_Lectins_ImmuneDev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801:SF63">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801">
        <property type="entry name" value="LITHOSTATHINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019366980" description="C-type lectin domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="39"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS77679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="295" mass="32875" checksum="2CACB2B2B321257E" modified="2019-05-08" version="1">MNSVQLAAEVAVILLSIFFNISEGCYYKDCKEQYVKVEHVGTCIKLSSNNASWTQARQLCQQENADLVKIVDGRMDQFISYLMNVGPNLYGYWIGCNDIKKEGVFAWLDEDVKIGYSNWQEGEPDQLTTEHCTEKRTQRFNGTWNDLTCTKKRHFICEYTPDCEDGYYGPNCTKKCSRNCAGENNPCSGPGGICQHGCVPGYLGGSCRQRCSIGYYGDGCSKKCSKNCIMCNNVDGKCYYCRFGYYGPQCSKTLEYDSWTLDGPLVAVVLVACVISVSAAFAIGSLVIRARLSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T9D6</accession>
    <name>A0A433T9D6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_014087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000529">
        <property type="protein sequence ID" value="RUS78158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T9D6"/>
    <dbReference type="OrthoDB" id="6145273at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019441126" evidence="1">
        <location>
            <begin position="19"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS78158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="267" mass="31325" checksum="4C0892345A20C173" modified="2019-05-08" version="1">MAAIQFVLLGTVIYLLAGDHVQGEGFYRFTNVANDSITGSCVPERRCGTVNTLWRDGALPAVHDGQLVKYIHHSETNNLYQYIHHSETNNLYQYIDHSETNNLYQYIHHSETNNLYQYIDHSETNNLYQYIDHSETNNLYQHIHHSETNNLYQYIDHSETNNHYQYIHHSETNNLYQYIHNDNTNHTCSNNKYSRNHDKDEAHRCVDQLTCHHEWFDESSDESKCQNYNSRDPRLQDLQCHFCCEGDACNTMIKPPTSSLYTLNAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TAM8</accession>
    <name>A0A433TAM8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cilia- and flagella-associated protein 206</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_013627</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential for sperm motility and is involved in the regulation of the beating frequency of motile cilia on the epithelial cells of the respiratory tract. Required for the establishment of radial spokes in sperm flagella.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CFAP206 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000499">
        <property type="protein sequence ID" value="RUS78621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TAM8"/>
    <dbReference type="STRING" id="188477.A0A433TAM8"/>
    <dbReference type="OrthoDB" id="10251073at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003356">
        <property type="term" value="P:regulation of cilium beat frequency"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021897">
        <property type="entry name" value="FAP206"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21442">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21442:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12018">
        <property type="entry name" value="FAP206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS78621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="634" mass="71851" checksum="1668E6066A2D9837" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TBQ4</accession>
    <name>A0A433TBQ4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vesicle transport protein USE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">USE1-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_013236</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the USE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000478">
        <property type="protein sequence ID" value="RUS78979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TBQ4"/>
    <dbReference type="STRING" id="188477.A0A433TBQ4"/>
    <dbReference type="OrthoDB" id="4506189at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15860">
        <property type="entry name" value="SNARE_USE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019150">
        <property type="entry name" value="Vesicle_transport_protein_Use1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13050">
        <property type="entry name" value="USE1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13050:SF7">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN USE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09753">
        <property type="entry name" value="Use1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS78979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="256" mass="29655" checksum="FA7FDB607A59C1C0" modified="2019-05-08" version="1">MQTKTNMAGSTRIEINFNRLLGQCQAMAEDKENRDWRFDKYIGSLQNFLVELKKSQSKPSQEVLLDYQRKVDLLKGLSEAEKKPSASDRALITERLRPVSTNVTSTRARELQIKAKVRCEDDLRAELFGSPTKSSHSEDADLPYLRQRKKAQDDEGDIDTILQHHHKIQEKLAEEMLQHTRALKYNFIEAGEIIKKDTKTVLDSHSLADTNMDKLKVESERLEAHTKTCSWWIWLMLLFVVITFVGMIPFMRLFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TEE2</accession>
    <name>A0A433TEE2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_012279</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000419">
        <property type="protein sequence ID" value="RUS79935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TEE2"/>
    <dbReference type="STRING" id="188477.A0A433TEE2"/>
    <dbReference type="OrthoDB" id="5981864at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000026">
        <property type="entry name" value="Rho GTPase activating protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000136">
        <property type="entry name" value="Rho GTPase activating protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051627">
        <property type="entry name" value="SLIT-ROBO_RhoGAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14166">
        <property type="entry name" value="SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="9">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="8">
        <location>
            <begin position="368"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="589"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="330"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="44"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS79935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="649" mass="74546" checksum="39F22B0755BAA772" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TEW0</accession>
    <name>A0A433TEW0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_012136</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="RQTK01000411">
        <property type="protein sequence ID" value="RUS80090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TEW0"/>
    <dbReference type="STRING" id="188477.A0A433TEW0"/>
    <dbReference type="OrthoDB" id="21018at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072354">
        <property type="term" value="F:histone H3T3 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000401">
        <property type="entry name" value="serine/threonine-protein kinase haspin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024604">
        <property type="entry name" value="GSG2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419:SF18">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12330">
        <property type="entry name" value="Haspin_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01331">
        <property type="entry name" value="DUF3635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS80090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="204" mass="23626" checksum="8493ED36E24FA001" modified="2019-05-08" version="1" fragment="single">DDQLFIVFEFAHGGCALESFKFESQREVLSVLRQIVFALAVAEQELEFEHRDLHIGNVLVKSCEEEEVTFVLDGGKFNFPTEGVIATVIDFTISRLKKDGCAVFCDISTDEGLFEGTGDIQFDVYRDMRIKNGNDWEEYHPETNVLWAKYLCTKLLTTNKVKNSRRAERHLQQHLRRLEQELSKYDSCTDLAFVLDFWDVLDIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TF22</accession>
    <name>A0A433TF22_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_012128</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000410">
        <property type="protein sequence ID" value="RUS80129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TF22"/>
    <dbReference type="STRING" id="188477.A0A433TF22"/>
    <dbReference type="OrthoDB" id="6101985at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052983">
        <property type="entry name" value="MFS_Riboflavin_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43385">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER RIBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43385:SF1">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER RIBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS80129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="48522" checksum="D402D1CF31AF2472" modified="2019-05-08" version="1" fragment="single">LEMEVPRLKKLSVLAGGVLLSTPLALTHFYGNLLPYLASYFHYHKDRMLYPMDPLWVATMFRSFFSLSMVFTSPIELRFGKFPCIVAGGVVMCVSVVCSYFAVVEPVALSLIFGVTHGIAVGVVYPLTLKLLLQTWGDKGGTAVGFMAMGPPLGAMINIGIAYGVINPTNKEADLEVGSHVYFSDADTLRHVPYYFLVMGGGLVVANVLGISLLYYGSRGVNHESIAPKRISSSRYMTLSENKDQTFSDKHTNIKDKTKPTGRSTPKIKFAFDLSPSEMLGTLQFWLVWLCCLGISHSFYVHLSLYKEYGQRAISNDALLASTAILGMAAMIFIRPNVGIVSDKFGIRATAFAMCAGSSVFMSLVVVGFYAGAAVFVVMTLVTFVLVSLQLMVTSILTSHYFGKTHYASNMGLVCSGQLLLIFLEPLLVEAVIDHLGWDYLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TF23</accession>
    <name>A0A433TF23_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_012077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000408">
        <property type="protein sequence ID" value="RUS80154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TF23"/>
    <dbReference type="STRING" id="188477.A0A433TF23"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS80154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="310" mass="33103" checksum="D497DBEF3001D9E6" modified="2019-05-08" version="1">MFYPWATAPPTRQVAEVPSQYKAFFENRYAQSKKQEARRLVSGDTVLPPSGAHKGSVSVTDVGEVRAHKGSVSGTDVGEVGALHKGSVSGTDVGEVGAHKGSVSGTDVGEVGAHKGSVSGTDVGEVRAHKGSVSGTDVGEVRAHKGSVSGTDVGEVRAHKGSVSGTDVGEVRPHKGSVSGTAVGEVGLAMSLLNPCHGRGQTCGVCNERYTHTHTHTYAHTHDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDEDVSTSSDDVTATVDNHDDDDDDDDDEEEEEEEEEKEEKEQEDEEQWEQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TGK7</accession>
    <name>A0A433TGK7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lipocalin/cytosolic fatty-acid binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_011523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000377">
        <property type="protein sequence ID" value="RUS80700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TGK7"/>
    <dbReference type="OrthoDB" id="6118769at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00742">
        <property type="entry name" value="FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS80700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="15561" checksum="21A291644ACBCAE9" modified="2019-05-08" version="1">MDAVLGSWKLKQGTQKNLDVFFKAVGIPDAAAEMYSKREVLLTFTKDGDKYTLTEVINNDPNKKSASYTVQMGKEIETIDIDDTPLKLKVQWDGSKFQETYLYPQLSPILTQREVAASLMKVAKTANGVTATEEWEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TGM6</accession>
    <name>A0A433TGM6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_011470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000374">
        <property type="protein sequence ID" value="RUS80747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TGM6"/>
    <dbReference type="STRING" id="188477.A0A433TGM6"/>
    <dbReference type="OrthoDB" id="413122at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS80747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="500" mass="56072" checksum="EC3A0F2233294546" modified="2019-05-08" version="1">MDVPFKRVAVDLVGPIDPTSEDGHRYILTLVDYATRYPEAVTLKRIVAEALVNIYSRLGVPEKILSDQGTQFMSACMREESTKFAPFELLYGRTVRGPMHILEQLWTKYIEEDELRSSYQYVLERREGLETTWEMAQKKLNYDRGTKARKFKPGDDVLVLLPTDTNKLLMQWKGPYKVVAVVGINDYRVKMGRKEKTVHANLLKRYVSRLDSETEDVDVDSPDTSSTQCARGDKADSVDVSPSIEPSKEITRTQSNAAVTTNGPASSPAMSSPETAARETAALMWMSDVTASAFTDDRIGQVPVETPSLPLEFYEAEERLLTCGLCISLAGVAAIREDPECGDQSIDEMAELCPWGQKETVKDLRYGHQLTDAQAEKVKSIVDEHQSIFTDLTGSTTLAEHRIELTSGTPIRQKPYGVPFSMRKSLRDEMRTMEEMGIIRKSSSPYAAHVVVVKKKNGSNRMCIDYRRLTKVTVFDPHPATPLQKFFNVSPRTNSSAKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TH12</accession>
    <name>A0A433TH12_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_011387</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000369">
        <property type="protein sequence ID" value="RUS80868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TH12"/>
    <dbReference type="STRING" id="188477.A0A433TH12"/>
    <dbReference type="OrthoDB" id="6054340at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000020">
        <property type="entry name" value="Latent-transforming growth factor beta-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050969">
        <property type="entry name" value="Dev_Signal_Modulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013111">
        <property type="entry name" value="EGF_extracell"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14949:SF56">
        <property type="entry name" value="EGF-LIKE-DOMAIN, MULTIPLE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14949">
        <property type="entry name" value="EGF-LIKE-DOMAIN, MULTIPLE 7, 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07974">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="3"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS80868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="94" mass="9850" checksum="19BDD881920C0A52" modified="2019-05-08" version="1" fragment="single">ATCEPPCLNNGRCVSPNQCLCPLGYSGSADCRPRCWPPCAHGGHCQRHNTCSCPAGWTGPSCRTPVCSPQCQNGGRCVGPDVCHCLEGFTGSHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TJV4</accession>
    <name>A0A433TJV4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Soluble calcium-activated nucleotidase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_010383</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the apyrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000317">
        <property type="protein sequence ID" value="RUS81860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TJV4"/>
    <dbReference type="STRING" id="188477.A0A433TJV4"/>
    <dbReference type="OrthoDB" id="25028at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030166">
        <property type="term" value="P:proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.100:FF:000001">
        <property type="entry name" value="Soluble calcium-activated nucleotidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.100">
        <property type="entry name" value="Apyrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009283">
        <property type="entry name" value="Apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036258">
        <property type="entry name" value="Apyrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13023">
        <property type="entry name" value="APYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13023:SF3">
        <property type="entry name" value="SOLUBLE CALCIUM-ACTIVATED NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06079">
        <property type="entry name" value="Apyrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101887">
        <property type="entry name" value="Apyrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR609283-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS81860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="417" mass="46904" checksum="0606F846C290BA51" modified="2019-05-08" version="1">MFPARAYYDRHSLFFAHMSLPVDEDNVNMLSSPYPSSVHEWTKAIRRPTSYRVGNARFHLKPRVVLYAGLFSAAVMLLLIMLLPRSPAQPLCNQMRGETVSKYDPTYPLTNPLSTPGGTVYQIGLITDLDKDSKSRDKKNAWLSYYRQGNLTVSEKGDSVKVSLKQPKVLVSNIASGDRGMELSELVIFNGKLYTVDDRTGIIYEIVGNTVVPWVILADGDGKVAKGFKCEWATVKGERLYVGGLGKEWTTEQGELVNLNPQWVKSIGPGGDVVHIDWHEKYNALRARTGMLAPGYIIHEAAVWSDIHKRWFFLPRRASKETYNEVDDERRASNLMFVVDENFESIEVRKVGALNPTHGFSSFKFIPGTGDRIIAALKSEEDQGKIASYMLAFDVHGKILMPEMKIGEVKYEGLEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TMZ3</accession>
    <name>A0A433TMZ3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_009388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000268">
        <property type="protein sequence ID" value="RUS82866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TMZ3"/>
    <dbReference type="STRING" id="188477.A0A433TMZ3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS82866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="103" mass="11563" checksum="17830B11DC966EF2" modified="2019-05-08" version="1" fragment="single">TGVYTYNTQHYTTPTSVYTDGTQHYTTPTGAYTDGTQHYTTPTGVYTYNTQHYTTPTGVYTYGTQHYTTPTGVYTYNTQHYTTPTGVYTDGTQHYTTPTGVYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TRU6</accession>
    <name>A0A433TRU6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB/POZ domain-containing protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_007963</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000211">
        <property type="protein sequence ID" value="RUS84270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TRU6"/>
    <dbReference type="STRING" id="188477.A0A433TRU6"/>
    <dbReference type="OrthoDB" id="6359943at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18492">
        <property type="entry name" value="BACK_BTBD16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056426">
        <property type="entry name" value="BTB_BTBDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042833">
        <property type="entry name" value="BTBD16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048859">
        <property type="entry name" value="BTBD16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46843">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46843:SF1">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23998">
        <property type="entry name" value="BTB_BTBDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21059">
        <property type="entry name" value="BTBD16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTBDG BTB/POZ" evidence="3">
        <location>
            <begin position="131"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="BTB/POZ" evidence="2">
        <location>
            <begin position="453"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS84270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="581" mass="66873" checksum="A190E8B39E3E7F4D" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TSS4</accession>
    <name>A0A433TSS4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL24</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_007644</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000200">
        <property type="protein sequence ID" value="RUS84617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TSS4"/>
    <dbReference type="STRING" id="188477.A0A433TSS4"/>
    <dbReference type="OrthoDB" id="1727108at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="TRASH" evidence="7">
        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS84617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="111" mass="13232" checksum="88DBED55F3EFC3BB" modified="2019-05-08" version="1">MRIELCSYSGYKIYPGHGKRMVKADGRTFNFLSHKCERSHMMKRNPRNINWTVLYRRKHKKGQVEEISKRRTRRTQKFHRAITGATLSDIMAKRNQKPEVRQAQREQAISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TVI8</accession>
    <name>A0A433TVI8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_006613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000164">
        <property type="protein sequence ID" value="RUS85601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TVI8"/>
    <dbReference type="STRING" id="188477.A0A433TVI8"/>
    <dbReference type="OrthoDB" id="2014058at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008699">
        <property type="entry name" value="NDUFB8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12840:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12840">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE ASHI SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05821">
        <property type="entry name" value="NDUF_B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS85601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="22127" checksum="EB403E39F73E7E8A" modified="2019-05-08" version="1">MATFMKVCSVLAKHKKPLICHRQSNLSTSSRLFAAFWNKDWKPGPIPRTPEERAAAAKKYGLRPEDYNALADGDIGDYPELPLVARSWRDPFEDYDLPGEKRNFGEPVNASADIIGADLWDPNADGRYTYGQMLMYGVLTFFGFVTAFLVLSPYEYFPPEMPKQYPFNNLYLEKGGDPANEPEIKHYTFKVPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TVQ7</accession>
    <name>A0A433TVQ7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_006546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000162">
        <property type="protein sequence ID" value="RUS85670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TVQ7"/>
    <dbReference type="STRING" id="188477.A0A433TVQ7"/>
    <dbReference type="OrthoDB" id="6112160at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="1">
        <location>
            <begin position="68"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS85670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="167" mass="17968" checksum="B52CCB3B0D7A73E0" modified="2019-05-08" version="1">MSARDTAVALQHSTLTVHLSSHATRRPVPQRLNMNALVVFTVLVGLAVAAPSREKRQVVCPDPFANVPSPCVNNPSQKVYFPHPTDNTKFLQCDIYGRMYIIQCPQGEVYENSLTACRAGTSAPRVTNPPAVVATTKPPTGLTFNPCTATALASGQLYFAIVGDNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TWL5</accession>
    <name>A0A433TWL5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein jagunal</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_006260</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the jagunal family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000154">
        <property type="protein sequence ID" value="RUS85990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TWL5"/>
    <dbReference type="STRING" id="188477.A0A433TWL5"/>
    <dbReference type="OrthoDB" id="8914197at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009787">
        <property type="entry name" value="Jagunal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20955">
        <property type="entry name" value="PROTEIN JAGUNAL HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20955:SF1">
        <property type="entry name" value="PROTEIN JAGUNAL HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07086">
        <property type="entry name" value="Jagunal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS85990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="22030" checksum="868ACEF1135324A0" modified="2019-05-08" version="1">MASRGGYRPEGSDGSDHWHRESIAWQYKISSINKGRLHFSLFLELVLGMLMFLRLLPGITGMLGLTVVSLRRLDLPHPRPWEYAWLVSLVVAVIGWRSTPQNNSFLLRQFILGTLVFGIAPILFGLFDLRKDIVSYVQERSFTYEMFGYPAVLLWSAFMIICLQIHIFSLYFSSVLLHAWKPRGPNKQKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TYQ1</accession>
    <name>A0A433TYQ1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chitin-binding type-4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_005559</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000131">
        <property type="protein sequence ID" value="RUS86685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TYQ1"/>
    <dbReference type="OrthoDB" id="64893at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019280123" description="Chitin-binding type-4 domain-containing protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-4" evidence="3">
        <location>
            <begin position="29"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS86685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="288" mass="32190" checksum="8048470A74A735C7" modified="2019-05-08" version="1">MGNPRYVSSRDFLCIVLLCVTLARRSEGHGYMIDPPARSSMWRVGFNTPVNYNDNALRCGGSRTSCGVCGDSVDSARDHETGGRFATGTIAKSYKQGDEVNLRITVTANHQGWFYFNLCARDDPSQPETEECLDRVPLKLADGRNRFPLRPRVFGVVNIRVKLPEDISCSHCVLRWKWITGNSWGRDPQTGEGCLGCGAQEQFYGCADVNIRPRNPSPRIPEVEVEEERVPQKTTTVAPPTSEAVLTRKCLAVNNWEGDPELDSWCDTNCNRMSPRFCPSVFCACQLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U0T0</accession>
    <name>A0A433U0T0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mediator of RNA polymerase II transcription subunit 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_004767</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Mediator complex subunit 14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000110">
        <property type="protein sequence ID" value="RUS87451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U0T0"/>
    <dbReference type="STRING" id="188477.A0A433U0T0"/>
    <dbReference type="OrthoDB" id="205099at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055122">
        <property type="entry name" value="Med14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013947">
        <property type="entry name" value="Mediator_Med14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809">
        <property type="entry name" value="MEDIATOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08638">
        <property type="entry name" value="Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator complex subunit MED14 N-terminal" evidence="9">
        <location>
            <begin position="21"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS87451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="261" mass="29298" checksum="92E7C37D44BB1336" modified="2019-05-08" version="1">MTPQGGMMIGMAPPTSSAGGTIPLTLLIEYGLHRTYHELQVLSELLPRKTDMERKIEIFQFASRTRQLFVRLLALVKWANSASKVDKCMDICNFLEQQSMYFVETADQLHKMAKETLASARLPSFSLPCAVDVLTTGTYPRLPTCIRERIIPPDPITPQEKAQTLQRLNEVIQYRLVSNELPKQMRRLKIDQGRVKFFVEHEFESLCHIGGFLALVGLLSVSVFGWLGCCVSMFLSGVANTASNVSSNGVFFSLRCTLFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-05-03" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U389</accession>
    <name>A0A433U389_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_004050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000090">
        <property type="protein sequence ID" value="RUS88218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U389"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS88218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="111" mass="11842" checksum="10DE190EA44C104E" modified="2019-05-08" version="1">MPIVGAYLQGDFNSIGGERRGPQIGPSVPLSSVAGRLSHTQLTRSSPGVGRHASSLGPGARRTHCCALHEWCKQVWFSVCHIDYSRKIAKRERGGHFPGCQATSSQSASIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U4J2</accession>
    <name>A0A433U4J2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_003523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000075">
        <property type="protein sequence ID" value="RUS88708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U4J2"/>
    <dbReference type="STRING" id="188477.A0A433U4J2"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="28"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS88708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="216" mass="24226" checksum="E76F009C4A9E57FD" modified="2019-05-08" version="1" fragment="single">GTIEEVTAPAVVSQYIQSISQSVSPYPLNNDHLNAIDFLYTYPRDARGEISVQTIIDMTTDTNFVVPSVLFARLITEASDQTDVFLYLLDHYPQVKDPSSPLRGSNHGHDILFEFDLTPALREDNMNDYIVVGTPTNTPLYGIFGGAVASFAKTGKPVSQLQTPQRWPRFDPIQENFFAVSLEPEVRSHLYAQRVALWLDFLPRVGSSWVTSRVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U4T8</accession>
    <name>A0A433U4T8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleoprotein TPR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_003392</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000072">
        <property type="protein sequence ID" value="RUS88847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A433U4T8"/>
    <dbReference type="OrthoDB" id="343070at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901673">
        <property type="term" value="P:regulation of mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057974">
        <property type="entry name" value="NUA/TPR/MLP1-2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012929">
        <property type="entry name" value="Nucleoprot-TPR/MLP1-2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057577">
        <property type="entry name" value="Nucleoprot-TPR/MLP1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898:SF2">
        <property type="entry name" value="NUCLEOPROTEIN TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898">
        <property type="entry name" value="NUCLEOPROTEIN TPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25481">
        <property type="entry name" value="Nucleoprot-TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25785">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07926">
        <property type="entry name" value="TPR_MLP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoprotein TPR/MPL1" evidence="9">
        <location>
            <begin position="172"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="NUA/TPR/MLP1-2-like" evidence="10">
        <location>
            <begin position="474"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoprotein TPR/MLP1-2" evidence="8">
        <location>
            <begin position="1054"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="627"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1523"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1681"/>
            <end position="1740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1874"/>
            <end position="2142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2173"/>
            <end position="2405"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="30"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="132"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="396"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="545"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="719"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="835"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="949"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1016"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1111"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1212"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="634"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1523"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1539"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1690"/>
            <end position="1703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1722"/>
            <end position="1738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1874"/>
            <end position="1887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1916"/>
            <end position="1943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1944"/>
            <end position="1954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1955"/>
            <end position="1968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1970"/>
            <end position="1986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="2009"/>
            <end position="2063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="2064"/>
            <end position="2074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="2075"/>
            <end position="2090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="2195"/>
            <end position="2204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="2238"/>
            <end position="2269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="2270"/>
            <end position="2282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2284"/>
            <end position="2299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="2339"/>
            <end position="2354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="2359"/>
            <end position="2369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="2374"/>
            <end position="2386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="2393"/>
            <end position="2405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS88847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="2405" mass="268861" checksum="DA15B5B1C083173B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U663</accession>
    <name>A0A433U663_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ABC1 atypical kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_003057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000063">
        <property type="protein sequence ID" value="RUS89178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U663"/>
    <dbReference type="STRING" id="188477.A0A433U663"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052402">
        <property type="entry name" value="ADCK_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45890:SF1">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45890">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 2 (PREDICTED)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="2">
        <location>
            <begin position="333"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS89178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="666" mass="75724" checksum="016FD28A1D4047C6" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U6V7</accession>
    <name>A0A433U6V7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Reticulocalbin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EGW08_002668</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">EC2010</strain>
            <tissue evidence="15">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum. Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3. By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis. Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens. This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with PCSK6 (immature form including the propeptide); probably involved in the maturation and the secretion of PCSK6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000052">
        <property type="protein sequence ID" value="RUS89550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U6V7"/>
    <dbReference type="STRING" id="188477.A0A433U6V7"/>
    <dbReference type="OrthoDB" id="293868at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16226">
        <property type="entry name" value="EFh_CREC_Calumenin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000104">
        <property type="entry name" value="calumenin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000090">
        <property type="entry name" value="calumenin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827:SF52">
        <property type="entry name" value="IP16409P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827">
        <property type="entry name" value="RETICULOCALBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019571969" description="Reticulocalbin-3" evidence="13">
        <location>
            <begin position="28"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="79"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="162"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="290"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="224"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="226"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RUS89550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="340" mass="39920" checksum="6F3CE90CCEA033F1" modified="2019-05-08" version="1">MSLVKATMKQIICVLVFVSLVTVYCNAIPTNEKKHQRGHEKSLSDQDHEIDGEHNSEYDHDAFLGHDDAKTFDQLSPEESKQRLGKIVDKIDKNGDGEVTEEELKEWIQYVQRRYIITDTERMWKDHEPETDDTLTWQAYQKRTFGYSDEPTEGSPTFEYKDMIERDHRRWKQADKDQDGKLSKEEFQDFLHPEEAEHMRGVVVDETLEDIDKDGDGKISLKEYIDDIWGDEDDHDDDDDDHEEGGDKEEEPDWVRTEREQFANFRDKNHDGHLDKEEIREWIIPEDYDHSTAEAAHLMRSSDDDGNGRLTKEEILEKYDLFVGSQATDFGEALTKHDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U719</accession>
    <name>A0A433U719_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_002640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000051">
        <property type="protein sequence ID" value="RUS89622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U719"/>
    <dbReference type="STRING" id="188477.A0A433U719"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035025">
        <property type="term" value="P:positive regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051480">
        <property type="entry name" value="Endocytic_GEF_Adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46006:SF8">
        <property type="entry name" value="DH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46006">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="155"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS89622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="32185" checksum="6FCA27F4E51BF42F" modified="2019-05-08" version="1" fragment="single">ELIGRLQEQRKPDGRTENIGQHIHDWADRLSVYVDYCANQIQAKAMFDEKKSEPAMEDFLQRCLASPFSRKLDLWTLLDGARGRFVKYPLLVRAILKYTQNSDDVYHLERALERLERIIHRADEETGASRCRHAKSSLVYLFEEQKLSAIDNSTALLCSGWMKNTKGSKLYVFLFDGAAVVTRSTLQQGRQMYQVYRQPIPASQLVVEDLPDGHVKLGSFRNAFGQGNQIAKNLIRISFAESGQGQAHTLLVSDEHDKRQWMQAFLKVATCLEPAPDAAKAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U7Z5</accession>
    <name>A0A433U7Z5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Ras-related GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EGW08_002293</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">EC2010</strain>
            <tissue evidence="15">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000044">
        <property type="protein sequence ID" value="RUS89941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U7Z5"/>
    <dbReference type="STRING" id="188477.A0A433U7Z5"/>
    <dbReference type="OrthoDB" id="10020193at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11384">
        <property type="entry name" value="RagA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.190:FF:000002">
        <property type="entry name" value="Ras-related GTP-binding protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000276">
        <property type="entry name" value="Ras-related GTP-binding protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039397">
        <property type="entry name" value="RagA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF1">
        <property type="entry name" value="RAS-RELATED GTP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12" id="KW-0458">Lysosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RUS89941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="35676" checksum="B52EECF4CFA1D9A9" modified="2019-05-08" version="1">MKKKVLLMGKSGSGKTSMRSIIFANYIARDTRRLGATIDVEHSHVRFLGNLVLNLWDCGGQEAFMENYFASQRDNIFRNVEVLIYVFDVESRELEKDIHYYQSCLEAILQNSPEAKVFCLIHKMDLVQDDQREIIFQERQEDLKRLSKPLDCTCFATSIWDETLYKAWSSIVYQLIPNVRQLEENLSNFAAILDADEVLLFEKATFLVISYTERVQHRDVHRFEKISNIIKQFKLSCSKIGASFDSMEVRNSSFAAFIETFTPNMVVMVVMSDTSIPSAATQLNIKNARKHFEKLETLVTPHRGMGSVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U9S8</accession>
    <name>A0A433U9S8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_001651</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000029">
        <property type="protein sequence ID" value="RUS90563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U9S8"/>
    <dbReference type="STRING" id="188477.A0A433U9S8"/>
    <dbReference type="OrthoDB" id="9046662at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15203">
        <property type="entry name" value="7tmA_NPYR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235:SF29">
        <property type="entry name" value="GH23382P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235">
        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="215"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="65"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS90563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="412" mass="46682" checksum="08653B7AA4154DEA" modified="2019-05-08" version="1">MSLPVGADILNDPNATLEELMAFLNGSPSDAYDAWKGDWTVLAEPRWQTAIITAYTIVIVFGFFANLLIVVVIARFKQLHTVTNIFIAYLAIADVALCVFNLPIQLHYQLNNKWAFGRILCHVVMPTFGVPFFSSSLAILMIAVDRYMLIVFPFKPRMSNGHAILTVALIVLFTIALTTPLIVSIQYVEIAHPIVKSVKTSCAEVYWPSYTHKRVYSVSIFLLQFVMPICLTSFFYTRICTVLHRRPVKKKDTRRNMRTNRILIAVVLTFTMCWLPWSVFALTSEFNNKFIPVRYFNVVDLLLKLFAMGSACINPFLYGWLNDNFKKELGKLFGYKMCCATSGRPGWRGGVSYSRTTDINNGTVLLRSEMYIRDKKASQDQFQVDYTPVGVQAGDELPLPHTVDAGRQAFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UBA4</accession>
    <name>A0A433UBA4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_001136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000018">
        <property type="protein sequence ID" value="RUS91111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UBA4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS91111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="97" mass="10828" checksum="0C352AD1E3BAA914" modified="2019-05-08" version="1" fragment="single">TCCDEEEEYNNSSVAEVEQSIHKATHLQLGEEEVHTVEEEVDGCEARCQERPPPPMVVLSTQVEIAQQNGRLTAGDDQDDEHKKQEAEHVVSLMGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UBN2</accession>
    <name>A0A433UBN2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Delta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_000957</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Putative Notch ligand involved in the mediation of Notch signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000015">
        <property type="protein sequence ID" value="RUS91245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UBN2"/>
    <dbReference type="STRING" id="188477.A0A433UBN2"/>
    <dbReference type="OrthoDB" id="6250255at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.140:FF:000001">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000003">
        <property type="entry name" value="fibrillin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001774">
        <property type="entry name" value="DSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052235">
        <property type="entry name" value="Nephronectin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24050">
        <property type="entry name" value="PA14 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24050:SF28">
        <property type="entry name" value="UROMODULIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01414">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 9" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 8 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 7 9" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="DSL" evidence="11">
        <location>
            <begin position="59"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="107"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU280815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS91245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="144" mass="16590" checksum="6ACD74BF3835F391" modified="2019-05-08" version="1">MMVAEAYDHDRFTSNDHMHTWGIRLRETVYPSRDQAHWAYRVMSQSYGKRPSLAFKIRLYCDPDFYTSKCNVYCKAEDSWKGHYTCDKASGQKVCHPGWEGSNCENDIDECSRDSNLCNHGTCVNSLGSYTCLCQDGYIGKQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UED1</accession>
    <name>A0A433UED1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_000117</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPPC13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000002">
        <property type="protein sequence ID" value="RUS92093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UED1"/>
    <dbReference type="STRING" id="188477.A0A433UED1"/>
    <dbReference type="OrthoDB" id="10250284at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010378">
        <property type="entry name" value="TRAPPC13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055428">
        <property type="entry name" value="TRAPPC13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055429">
        <property type="entry name" value="TRAPPC13_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055427">
        <property type="entry name" value="TRAPPC13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13134">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13134:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23643">
        <property type="entry name" value="TRAPPC13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23647">
        <property type="entry name" value="TRAPPC13_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06159">
        <property type="entry name" value="TRAPPC13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex subunit 13 N-terminal" evidence="2">
        <location>
            <begin position="10"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Trafficking protein particle complex subunit 13 middle" evidence="4">
        <location>
            <begin position="172"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Trafficking protein particle complex subunit 13 C-terminal" evidence="3">
        <location>
            <begin position="318"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS92093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="46745" checksum="034923C0B2C1C065" modified="2019-05-08" version="1">MEGSRDREQLLALKVMRLTKPTLMPHQTLVSESRDLCGDALARLNDVEVARTPGLSAFPLGSLLTLPQNFGNIFLGETFSSYISVHNDSSQLCKEITLKADLQTGSQRLSLSSVSPQPIPELQPDHSIDDVIHHEVKELGTHILVCAVSYMLTSGERMQFRKFFKFQVLKPLDVKTKFYNAEKLEADEGLPLQSDEVYLEAQIQNITPGPIYMEHVSLDPSQQYTASELNNKDGKDVAPVFGNMASLAPNDTRQYLYCLTPKPELYQDARLLKGVTNIGKLDIVWKTTMGERGRLQTSQLQRVAPGYGDIRLTVESVPDTVALESTFELVCRITNCCERTMDLTLVLQNVTSHSGLLWCGVSGRQLGKLPHNESLDIPLSLISIVPGLQTISGLRLTDNFLKRTYEHDEIAQVFVVAVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z7A9</accession>
    <name>A0A3S0Z7A9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_019949</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001086">
        <property type="protein sequence ID" value="RUS72289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z7A9"/>
    <dbReference type="STRING" id="188477.A0A3S0Z7A9"/>
    <dbReference type="OrthoDB" id="6141508at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF375">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS72289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="23389" checksum="C888DD279F7CFF62" modified="2019-04-10" version="1">MWHGTTTTGATLYWAVLYILNYPDVAARARDQITDYLLQLEDRNSSAGAGDTSSPTAKIEIPAYFKAFIHEVQRCANICPLSMAHAVAKEKFLKGYRVPGDAVILPNLDSLMMDEDIWGDPEVFRPERFLNSDGKLSVPTEFIPFFIGIRNCPASSIAQNILLTNLIYILYHFDLEPEVQGQVPPMVRQKGLIPMPKDFKIKFIPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z7W2</accession>
    <name>A0A3S0Z7W2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Non-specific serine/threonine protein kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_020864</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001225">
        <property type="protein sequence ID" value="RUS71368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z7W2"/>
    <dbReference type="STRING" id="188477.A0A3S0Z7W2"/>
    <dbReference type="OrthoDB" id="2156623at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd20814">
        <property type="entry name" value="CRIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000081">
        <property type="entry name" value="Citron rho-interacting serine/threonine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF71">
        <property type="entry name" value="CITRON RHO-INTERACTING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="8">
        <location>
            <begin position="231"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="312"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="9">
        <location>
            <begin position="452"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="159"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="784"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="816"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS71368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="836" mass="92264" checksum="76C5FA5BABDF9B39" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZA89</accession>
    <name>A0A3S0ZA89_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_017930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000844">
        <property type="protein sequence ID" value="RUS74307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZA89"/>
    <dbReference type="STRING" id="188477.A0A3S0ZA89"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS74307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="251" mass="28979" checksum="1CE22C20691D4B04" modified="2019-04-10" version="1" fragment="single">MVTVSLLYPYIHHNMVTLSLLYPYIHHRMVTVSLLYPYIHHRMITVSLLYPYIHHRMVTVSLLYPYIPYPYIHHRTVTVSLLYPYIPYPYIHHRTVTVSLLYPYIPYPYIHHRTVTVSLLYPYIHHSIPTLSIHPSQNGHSIPTLSIHPSQNGHSIPTLSIHPSHSIHTLTIHPSQSGHSIPTLSIYPLSIHPSLDGHSIPTLSIHPSQNGLSIPTLSIVTSLAGWVPQFYYNYYNYDGYPVLRLHTTIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZAV5</accession>
    <name>A0A3S0ZAV5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Laminin G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_018748</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000930">
        <property type="protein sequence ID" value="RUS73488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZAV5"/>
    <dbReference type="STRING" id="188477.A0A3S0ZAV5"/>
    <dbReference type="OrthoDB" id="430340at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Laminin G" evidence="3">
        <location>
            <begin position="227"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS73488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="417" mass="43639" checksum="B44E26F12885FB31" modified="2019-04-10" version="1">MGMARAGLSSTTGGRVRYTPQTMGERRTSPLPIDASPSSSSSSSAITTPASENRFLSTLLPPASSSAVALLESTSLSSPASSSPSLSSLGSLPYHWTAQNEMPTSSPSVPSAKRRARSRLDLDLPPVMMPSSKSAFDASSTLLKPVGSRVPSNTSKIQPTVPSSKVQSTTLSPKIHAIPSSPKAHLTVSSPKVHQTAPSPFLSLRTLAMLSLTLTVLCPPPGVTANKDRAYFNSSAYLSIPHYTWSYSGPLQVTFRTCSGNGELLSLVQEASSSSSSSSSSLSSLALRLVNGSVALSWNLTTGQSQSVAAPVGRVVSDNAWYRVRVRYQLEALTLAVYGAALSESSLGEVVVANSSYNSVLLTTSLTGTLTIGQGFHGCMFQGPGVDFNTPGLVAFGVDWDTCPQFQGCSSGECRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZBN5</accession>
    <name>A0A3S0ZBN5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_020987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001246">
        <property type="protein sequence ID" value="RUS71252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZBN5"/>
    <dbReference type="STRING" id="188477.A0A3S0ZBN5"/>
    <dbReference type="OrthoDB" id="6145333at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018601271" evidence="1">
        <location>
            <begin position="24"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS71252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="114" mass="13001" checksum="351FD6DE9E1BFA28" modified="2019-04-10" version="1" fragment="single">MAVRLKHLVAALLLVTALPTVRTSRIISAFEDFHERFQASYLRNQNLKKIVTDLSRQVMLQQFFVEEKIRSDGSSGIKLIRGGSKGLDNYDSNSHTSNYFMAIHDHSNYDRTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZC86</accession>
    <name>A0A3S0ZC86_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_020619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001186">
        <property type="protein sequence ID" value="RUS71627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZC86"/>
    <dbReference type="STRING" id="188477.A0A3S0ZC86"/>
    <dbReference type="OrthoDB" id="6129861at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF3">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="59"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS71627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="214" mass="23491" checksum="0DC6C42163E5A464" modified="2019-04-10" version="1" fragment="single">MEESYDVLNGEQSEINLEINELKPYKDYTMTVHAVNMAGFGLPESVSSMTEIGVAKELVSLIVQKTGTDSTAGLNLIWIAGEKTGPTNYSVRVEEAKSISSSEYLLSSFRTVEGYSTTSFQVSDLIAYWSYQVTVTAVTSAGSGPSKTETLITKSNKPGEVTNFDVELSANDAQVFDLTFECPIEKERNGILKEYIVQKQVQGVSCFTFYSYIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZGU3</accession>
    <name>A0A3S0ZGU3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_017686</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000821">
        <property type="protein sequence ID" value="RUS74538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZGU3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS74538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="205" mass="22322" checksum="41FA83D4DFC07328" modified="2019-04-10" version="1" fragment="single">MFYLPQHFHFTFLSNSPHLPSDSKTLTSSILSLTLLLLGVTSICYSSLSLTLTSISLSLSPSPLLSQSLLTSAPPFHLHYLLLLSLSPPSFPLHPLCCNLSLHLTSFFPSTLSNHSFPPHLPPHYSITFLLSISSFMPPLSLTALLPSRLFQLWPLQERGAESWGRGRCCALPSAITRSISSTVRGTQDSSSMPVSVIAMSSSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZHS4</accession>
    <name>A0A3S0ZHS4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Homeobox protein cut-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EGW08_013046</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">EC2010</strain>
            <tissue evidence="17">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CUT homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000465">
        <property type="protein sequence ID" value="RUS79188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S0ZHS4"/>
    <dbReference type="OrthoDB" id="10257567at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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</entry>
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    <name>A0A3S0ZJF9_ELYCH</name>
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            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001977">
        <property type="protein sequence ID" value="RUS68842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZJF9"/>
    <dbReference type="STRING" id="188477.A0A3S0ZJF9"/>
    <dbReference type="OrthoDB" id="6148502at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16029">
        <property type="entry name" value="4-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047115">
        <property type="entry name" value="ARSB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342:SF273">
        <property type="entry name" value="RE14504P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="7">
        <location>
            <begin position="3"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS68842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="384" mass="43422" checksum="097188A0F64F50FF" modified="2019-04-10" version="1" fragment="single">LSRWHLGFCKWECTPTYRGFDSFFGFYSGAEGYYTHQMREFNCLINQLDTILQPILTNYYCPQYDFASRAEQIIQAHDQTKPLYMYMPFQSVHMPLQVPDKYLEMYPNITNKNRKALSAMVTSLDDAIGRVVKALQDKDLYKDSIIVFTADNGGWTIYGGNNYPLRGGKVTVFEGGTRAAAFIHSPLLAKTGVTHDGMMHAVDWFPTLASALGITYSDSLDQDGVDQWEAITTLGPSKRTEIVYNMDYHPFPAEGQSAIRVGDYKLIEGFPGLYPGWYKPDSVDQGLNISTGYLTNLSPDSSTVRGWMKSALGESSLKEQKFLFNLKDDPTEHNNLYDKQPDIVKQLQGRLAEQMKRYVPPNFPGNDPKANPKHFGGVWSPGWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZJN0</accession>
    <name>A0A3S0ZJN0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_012990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000462">
        <property type="protein sequence ID" value="RUS79260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZJN0"/>
    <dbReference type="STRING" id="188477.A0A3S0ZJN0"/>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16468">
        <property type="entry name" value="RING-H2_RNF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042981">
        <property type="entry name" value="RNF11_RING-H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052804">
        <property type="entry name" value="UEC_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46359">
        <property type="entry name" value="GEO07743P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46359:SF2">
        <property type="entry name" value="GEO07743P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="99"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS79260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="154" mass="17514" checksum="BA105126ACE31B3B" modified="2019-04-10" version="1">MGNCFKSSSNDDISLLRGTDTESNESAIEHPPFVEPPPPYRAQPEPQRRMPIYHPSPSVSRPANQLSEDEQIKIAQRLGLINHLPTGKYDGTNKKAKECVICMNEFELAEPLRYLPCMHTYHKECIDDWLMRSFTCPSCMEPVDAALLTTYQTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZJR5</accession>
    <name>A0A3S0ZJR5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[acyl-carrier-protein] S-malonyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_023185</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>holo-[ACP] + malonyl-CoA = malonyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FabD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="2"/>
    <dbReference type="EMBL" id="RQTK01001851">
        <property type="protein sequence ID" value="RUS69054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZJR5"/>
    <dbReference type="STRING" id="188477.A0A3S0ZJR5"/>
    <dbReference type="OrthoDB" id="541883at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.250:FF:000001">
        <property type="entry name" value="Malonyl CoA-acyl carrier protein transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.250">
        <property type="entry name" value="Malonyl-CoA ACP transacylase, ACP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050858">
        <property type="entry name" value="Mal-CoA-ACP_Trans/PKS_FabD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024925">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004410">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc_FabD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00128">
        <property type="entry name" value="fabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42681">
        <property type="entry name" value="MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42681:SF1">
        <property type="entry name" value="MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000446">
        <property type="entry name" value="Mct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="6">
        <location>
            <begin position="2"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS69054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="296" mass="32440" checksum="51FABDF4EB30AB61" modified="2019-04-10" version="1" fragment="single">IVFPGQGSQKPGMLTDYYNTYETFKNILDQAREHLGYDLWDIIQNDPDKLGQTEYTQPALLATSYAIFKVLEEQKPDLKPTYMAGHSLGEYTALLAAGCISYKDALQLVSLRGQLMQNAVTDKECAMSAILGLSNEDVIASCQEASDVGVVEAANFNSTGQVVISGEKEAVEKANTIAKEKGAKRAQILAVSVPSHCSLMIDAAKKFEEALNNVEFNKPNTAIVQNFDAKAHDSTDSIKSNVIKQLYKPVLWTQSVQELCNNGVTEVIECGPNKVLCGLIKRIEKDLIIKDTNTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZKY9</accession>
    <name>A0A3S0ZKY9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_010896</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000343">
        <property type="protein sequence ID" value="RUS81329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZKY9"/>
    <dbReference type="STRING" id="188477.A0A3S0ZKY9"/>
    <dbReference type="OrthoDB" id="6122308at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS81329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="299" mass="33482" checksum="9F606B2B219695DE" modified="2019-04-10" version="1">MARNKFTSKAGDALGKMIGQASLMELNVSGNQLRGEGMTAFLTNIARNSNLERLDVSWNGIGPDAVRGLCTLIRQSTSLTSVDLTATGLNGECLDLICTQGLSKNGVLQRIELKNNPLLTHDLTTFLTRLYSYPTTAIRRVDLGDYQMLDSSVEQLLEELFWEKQIYVRSAGTFTYSRKKDSIENISSRFRKDSLSLVTRLDHGQRTALVKHFANVDMQEAVETGSDIITNSFLGRANDNKVTYKDLALRINIEKGNPRDVINSILEKQVIPEGSKRLIPRFSFSPEEIRKTHLLTQHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZN53</accession>
    <name>A0A3S0ZN53_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_009338</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000266">
        <property type="protein sequence ID" value="RUS82915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZN53"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015375">
        <property type="term" value="F:glycine:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF240">
        <property type="entry name" value="BLOATED TUBULES, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00754">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0769">Symport</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="437"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="468"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="551"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS82915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="650" mass="72584" checksum="4185B7B25C55EE02" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZPL8</accession>
    <name>A0A3S0ZPL8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">A-kinase anchor protein 7-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_008318</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000225">
        <property type="protein sequence ID" value="RUS83904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZPL8"/>
    <dbReference type="STRING" id="188477.A0A3S0ZPL8"/>
    <dbReference type="OrthoDB" id="277832at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034237">
        <property type="term" value="F:protein kinase A regulatory subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010738">
        <property type="term" value="P:regulation of protein kinase A signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019510">
        <property type="entry name" value="AKAP7-like_phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052641">
        <property type="entry name" value="AKAP7_isoform_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15934:SF2">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 7-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15934">
        <property type="entry name" value="RNA 2',3'-CYCLIC PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10469">
        <property type="entry name" value="AKAP7_NLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A-kinase anchor protein 7-like phosphoesterase" evidence="2">
        <location>
            <begin position="152"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS83904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="346" mass="39944" checksum="11A39AF2087BA838" modified="2019-04-10" version="1" fragment="single">DETHFLSLSSKTLSKKDLQRLQRSVELQIAISENTQKIVEALKIINKFIEDESLHDRNNCVPSKKKNRKSSRPTRNNGGMDESVEETTDERKIHVAKRKGKKAKRRSRHTAASEDSEDSYDNEQTPSSLYGSTFSENVQEVVQSSLPLSARPTHFLAVCVRNKEILDRLSAVQRELVSREPLLEKGAFAPEIFHLTLFTLGLDSSEDIENCVQALRAMKRNGLDKFRTLKPVIIHGMSQFYNRAIFAKVKFEQDFIDFREHMKNELGSFNVEIRDMYEKFNPHLTIIKVKRPERKLFGSRNIQPAIYSQFKDVVFGEQTVDDIHLCSMDGQRREDGFYVSLFEINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZPR2</accession>
    <name>A0A3S0ZPR2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_008280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000223">
        <property type="protein sequence ID" value="RUS83974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZPR2"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS83974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="141" mass="15909" checksum="1092212CFEFAFEB0" modified="2019-04-10" version="1">MEELKCLQCDDGEDEEDLLCDDGEDEEDLLCDDGEDEEDLLCDDGEDEEHLLCDDGEDEEHLLCDDGEDEEHLLCDDGEDEEHLLCDDGEDEEHLLCDDGEDEEDLLCDDGEDEEHLLCDDGEDEEDLLCDDGEDEEEGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZQE0</accession>
    <name>A0A3S0ZQE0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ras-related protein Rab-1A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_019403</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001011">
        <property type="protein sequence ID" value="RUS72838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZQE0"/>
    <dbReference type="STRING" id="188477.A0A3S0ZQE0"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01869">
        <property type="entry name" value="Rab1_Ypt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000069">
        <property type="entry name" value="Ras GTP-binding protein YPT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057289">
        <property type="entry name" value="Rab1/Ypt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="182"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS72838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="22882" checksum="7DB1543AA5DDF13B" modified="2019-04-10" version="1">MSTMNPDYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKLIKLQIWDTAGQERFRTITSSYYRGAHGIIVVYDVTDQESFNNVKQWLQEIDRYASENVNKLLVGNKSDLTTKKVVDFTTAKEYADQLLIPFLETSAKNATNVEQAFMTMAAEIKKTMGPITAASDSKPSVKINSSTPVNPRQGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZS31</accession>
    <name>A0A3S0ZS31_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutathione transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_007732</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">S-crystallins are structural components of squids and octopi eye lens. Contains relatively little if any GST activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000203">
        <property type="protein sequence ID" value="RUS84493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZS31"/>
    <dbReference type="STRING" id="188477.A0A3S0ZS31"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005212">
        <property type="term" value="F:structural constituent of eye lens"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000030">
        <property type="entry name" value="Glutathione S-transferase S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000035">
        <property type="entry name" value="hematopoietic prostaglandin D synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF150">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0273">Eye lens protein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="4">
        <location>
            <begin position="5"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Glutathione S-transferase C-terminal" evidence="5">
        <location>
            <begin position="96"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00049616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS84493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="23245" checksum="1E33D26BE216A6D2" modified="2019-04-10" version="1">MPHYKLTYFDFRGRAEIARLMFAYAGKEYEDHRIQVEDWSAVKPNTPFGQIPVLEVDGEEIGQSVAIANYLAREFGLYGKTNMESCQIDQVVCLIQDLINAFVKAMFEIDPAKKAEMMRVNNEEVVPRFLGFFESILKKNGTGFFVGSDITLADFFIYDSTWNLIKSTPTLLDNFPNLKQHRDRIGSVPQIKAHVDARKPTEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZU67</accession>
    <name>A0A3S0ZU67_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_006274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000155">
        <property type="protein sequence ID" value="RUS85945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZU67"/>
    <dbReference type="OrthoDB" id="6107575at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS85945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="335" mass="38472" checksum="0D6765FD0A7FBDA1" modified="2019-04-10" version="1">MLHFGIPRAPEFSQVTMWRMPMSAEDQEERDERRKRTAASRTTSTLSSLPQSRYQRYNTAEGNTIYGMCRENIASRGLTVPSHPPTPQHCHLLPRNIELCEERDYIDRCLFQDYTGDNFNKMIMQNFFKAPKARSLGYGMPRPETREGVQDRMISTLSRKPSPSVVRVPSHTSLCKPVKCDSHTGCSEEFCEILGPGCCSSCIETTNRQIAEEIQHRLFPEIEVSRRCLVVPKLTKVMKDGHVKQMRRRRLQELRQQTVKEEEEPVKEEMTVAKEEEKKKIPETAERAVTAVSNANVPPTIPRRTNHYTRRESMPLPPIGPPQPTFSVSSLDSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZVI2</accession>
    <name>A0A3S0ZVI2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_015986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000678">
        <property type="protein sequence ID" value="RUS76243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZVI2"/>
    <dbReference type="OrthoDB" id="10514173at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS76243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="332" mass="38141" checksum="31D2340037D34FDF" modified="2019-04-10" version="1" fragment="single">NSVLSEGYLTGKGLESSKDENPKTHPTKTVKQNPDITKENRSNKVKPEVRDPDTSESFNIKVDIKRRQKSPHGAKDPEGTLDHGYKPSEPNRSMRQLRWSTSALGDAPKQPAPDNSHGKEVSRKIGPKFKNLCVRSEFTFSTYDFYNKHNSEGWWSSTIHTRTKSPQGRDLVDEETKIEELKNYKKIFSHGGIEQLVKGWAQETYRARALHMLLSGGAREEEGEEDEPVAPLLAHLKKQQQAPPDSLPSIFTSMRRNSVPPKPMRKSSVFYALPSFEHLPEQERIRKRKIRNFRWYSHMIRAMVRLSANMRQLSRDLTHKSAYSEFLYILAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZXX0</accession>
    <name>A0A3S0ZXX0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LRRK2 ARM repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_002837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000057">
        <property type="protein sequence ID" value="RUS89400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZXX0"/>
    <dbReference type="OrthoDB" id="7537227at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056597">
        <property type="entry name" value="ARM_LRRK2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23744">
        <property type="entry name" value="ARM_LRRK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="1">
        <location>
            <begin position="10"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS89400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="144" mass="15784" checksum="B35FE228AD5330A3" modified="2019-04-10" version="1" fragment="single">MRSGASDYDLQLEGIRTIGAFAEEETLKVLFAKSEAISCIIDAMKEFQDKEELQLNACSSLLKMASASESNCVHILRNKGVSAISCSLRRHLDNPDIVRKLINIVFYISTAVDLAEALVAGGVHSEILSVMSRHASDREIVKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZZS8</accession>
    <name>A0A3S0ZZS8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase RBP11-like dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_013067</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000467">
        <property type="protein sequence ID" value="RUS79159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZZS8"/>
    <dbReference type="STRING" id="188477.A0A3S0ZZS8"/>
    <dbReference type="OrthoDB" id="10248581at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06926">
        <property type="entry name" value="RNAP_II_RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.10:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037685">
        <property type="entry name" value="RBP11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008193">
        <property type="entry name" value="RNA_pol_Rpb11_13-16kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF16">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01154">
        <property type="entry name" value="RNA_POL_L_13KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="6">
        <location>
            <begin position="31"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS79159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="118" mass="13321" checksum="C00BC163C27684FC" modified="2019-04-10" version="1">MNAPSTFESFLLFEGEKKISIEKDTKVPNAALFTVNKEDHTLGNLITTQLLKDPQVLFAGYKIPHPLEHKFVLRIQTTPDYTPGEAFTNAITDLISEVSLMEERFKDAVRDRQEGSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A0Q0</accession>
    <name>A0A3S1A0Q0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_012471</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000429">
        <property type="protein sequence ID" value="RUS79755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A0Q0"/>
    <dbReference type="STRING" id="188477.A0A3S1A0Q0"/>
    <dbReference type="OrthoDB" id="10458449at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01208">
        <property type="entry name" value="VWFC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFC" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS79755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="152" mass="16060" checksum="A9076C0AF886B7D9" modified="2019-04-10" version="1" fragment="single">EVYFPYVEDPCYKCTCKDGDVDCQYLDCADDTVCADGSEPYIVEGECCLQCPDGANEGLPNRVESGTQNQQPGGDKAGPVYSAAMSYAAPGQQGPRGSPGPPGAPGQPGYQGARGESGEPGPPVSCHGNRPYYFCCLFVFKTSNGMHAFSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A1E5</accession>
    <name>A0A3S1A1E5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_004077</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMAUG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000091">
        <property type="protein sequence ID" value="RUS88180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A1E5"/>
    <dbReference type="STRING" id="188477.A0A3S1A1E5"/>
    <dbReference type="OrthoDB" id="2155283at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030371">
        <property type="term" value="F:translation repressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09557">
        <property type="entry name" value="SAM_Smaug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000013">
        <property type="entry name" value="Protein Smaug homolog 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.170">
        <property type="entry name" value="Smaug, PHAT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037093">
        <property type="entry name" value="PHAT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058599">
        <property type="entry name" value="PHAT_Smg/ZCCHC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050897">
        <property type="entry name" value="SMAUG/VTS1_RNA-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037634">
        <property type="entry name" value="Smaug_SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057327">
        <property type="entry name" value="Vts1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515:SF5">
        <property type="entry name" value="PROTEIN SMAUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26034">
        <property type="entry name" value="PHAT_SMAUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25479">
        <property type="entry name" value="Vts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="SAM" evidence="7">
        <location>
            <begin position="578"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="200"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="271"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="409"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="677"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="837"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="423"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="482"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="504"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="544"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="684"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS88180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="925" mass="99432" checksum="EAB2153F44CDAFC1" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A1J9</accession>
    <name>A0A3S1A1J9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_011886</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000397">
        <property type="protein sequence ID" value="RUS80347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A1J9"/>
    <dbReference type="STRING" id="188477.A0A3S1A1J9"/>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000052">
        <property type="entry name" value="Lysine histidine transporter-like 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF703">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="21"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS80347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="414" mass="44210" checksum="5DA10AC716D293BA" modified="2019-04-10" version="1">MAEEDSIPLVDRPIEMGLTGPTTTVFLVGVMAGSGTLVIPKALSDAGWSGILIILAMAAASTYTAILLGRCLTILRSRHVEYHGHIRGPYPAIGQAAFGKVCRCLITVCVDFSSFGTCVAYLLLIAENIGFLVARFGFDMPYYYWLLAVVLVLCPLCWFGSPKDFTFIGVIAAVATGVACVIILSQMAIDAQRVPPAIHGPVLLKPFLMAFGTICLGFGGHPAIPTILVDMKHPEKYVTSITPAFLIVVLIYLPLSLVGFLVYGSNLNPNVLLTITPGPAIFTVQILMSVHLLTGFVLLLNPVCQEGEDLLNIPHQFGLRRVLFRTALLALTFIIAIAIPNFGVILAFLGGSTVTALVFILPPVLYLRLCAMTGTWDKIDIPLHEKVLCVEIIVVGGLAGATATFSAVEALVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A2E3</accession>
    <name>A0A3S1A2E3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_003311</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000071">
        <property type="protein sequence ID" value="RUS88872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A2E3"/>
    <dbReference type="STRING" id="188477.A0A3S1A2E3"/>
    <dbReference type="OrthoDB" id="6163199at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="21"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="62"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS88872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="184" mass="20530" checksum="E5C0800D622404EA" modified="2019-04-10" version="1" fragment="single">MNPLDLDRVVQEAQEANELTEMDDCLEVAFKVLDFDEDGFITQPDIYQLMLRLGEMLADYALDDMLAAVDKDQDGKISLRDFRYFLLGRDVPSRKEIFAMAAEAKKKREEAEIKAEEEAEKQKFELLKSGQCAPEREAEEAEEAEEAEEAEEAEEASAPDKQGEDTPQLESPGLETGGVEGGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A3R9</accession>
    <name>A0A3S1A3R9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cyclin-dependent kinase 20</fullName>
            <ecNumber evidence="5">2.7.11.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Cell cycle-related kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Cell division protein kinase 20</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">EGW08_010183</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">EC2010</strain>
            <tissue evidence="26">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="5"/>
    <dbReference type="EMBL" id="RQTK01000306">
        <property type="protein sequence ID" value="RUS82053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A3R9"/>
    <dbReference type="STRING" id="188477.A0A3S1A3R9"/>
    <dbReference type="OrthoDB" id="63265at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07832">
        <property type="entry name" value="STKc_CCRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000406">
        <property type="entry name" value="cyclin-dependent kinase 20 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000211">
        <property type="entry name" value="Putative cyclin-dependent kinase 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048002">
        <property type="entry name" value="CDK20-like_STKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF171">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 23 24" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0966">Cell projection</keyword>
    <keyword evidence="14" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 23 24" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 24" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="25">
        <location>
            <begin position="4"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00035711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00035720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00035723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="RUS82053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="347" mass="39237" checksum="FD36A6F8A707B746" modified="2019-04-10" version="1">MDQYNILGRIGEGAHGIVLKAKHIESGEVVALKKVPLRNHEEGIPNTALREIKALQEIESNPYVVRLREVFPHGSVIVFVFEFMLSDLSEVIRKVEKPLTEAQVKSYMLMLLKGIAFCHENNIMHRDLKPANLLISSTGHLKIADFGLARVFQNKGDRQYSHQVATRWYRAPELLYGARKYDEGVDMWAVGCIFGELLNNSPIFPGETDIEQLCLVIRVLGTPNEKTWPGMSKLDLPDYHKISFPDKPPIPLEEIVPDASEEALALLKQFLVYPSKQRISAKKALLHPYFFTEPLPAHHSELPIPQRSSRRSGLQLKHQAHEYNLDTPIGDSLVDPDLLAPHVIKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A786</accession>
    <name>A0A3S1A786_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SRCR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_007806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000206">
        <property type="protein sequence ID" value="RUS84422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A786"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.70">
        <property type="entry name" value="DNA packaging chaperone protein FI, C-terminal beta-strand domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043043">
        <property type="entry name" value="Packaging_FI_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018753536" description="SRCR domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS84422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="16836" checksum="E747F925537AF84C" modified="2019-04-10" version="1">MLTAVLQLHISALHCSNGEHVGTVYVSTAVLHISALHCSNDEHVGTVYCSNGEHVGTVYCSNGEHVGTVYCSNGEHVGTVYVSTAVLHISALHCSNDEHVGTVYVSTAVMVNMWVQCTAVMMNMWVQSTAVMVNMWVQSTAVMMNMWVQCTCLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AFT9</accession>
    <name>A0A3S1AFT9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_001491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000025">
        <property type="protein sequence ID" value="RUS90780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AFT9"/>
    <dbReference type="OrthoDB" id="6287659at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS90780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="298" mass="33245" checksum="28E1339ABE6921F6" modified="2019-04-10" version="1">MTQNRPLFLNNRLIPRPSTCTPISSKRIVSLEISIIPLGPDRNQQINKTKDKATDPSTKSPLCSASNLDTVEAIRRSYLRAQSAPPLASRADGAHTSENARINSSLLAPTQSGLDDGRKFSSPYWRARSAYHRRNADVNEAEASDLKSLEFSGAHESSQLKGTLLRPLLYTSDSGFMKHSAGCPYKCKNCFRACLVSDDFAQKAQHRRQELISKLREGDKTNANHDPISKRIYKHKEHRLDAIAIVQRALARNQPLFQRVYGGKGHPPALLPWPTYAWVDIKQKKTDKDTGASSDDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AX36</accession>
    <name>A0A3S1AX36_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_022697</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001648">
        <property type="protein sequence ID" value="RUS69542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AX36"/>
    <dbReference type="STRING" id="188477.A0A3S1AX36"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042634">
        <property type="entry name" value="MOX-1/MOX-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24328:SF7">
        <property type="entry name" value="BUTTONLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24328">
        <property type="entry name" value="HOMEOBOX PROTEIN MOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="52"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="54"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="131"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS69542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="195" mass="21880" checksum="518280DC89D0CFC6" modified="2019-04-10" version="1">MPDHRGGSGVALETSSKVLTPYVIHPNVYERAFLLQGINYNSPDPYKLDLSVKPRKERTAFTKHQIQELEKEFSLHNYLTRLRRYELAVALDLTERQVKVWFQNRRMKWKRVKGTKLVKDKVDGQLKPIMAPNVTSTQHGGTGNAACTNSGGDSGRLSGMHRQDSLDGSSCREDADDMSDEMDDISDMAGIPALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AXH2</accession>
    <name>A0A3S1AXH2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_022456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001577">
        <property type="protein sequence ID" value="RUS69781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AXH2"/>
    <dbReference type="STRING" id="188477.A0A3S1AXH2"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051063">
        <property type="entry name" value="PDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672:SF2">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="33"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS69781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="151" mass="17156" checksum="B833156BD476844C" modified="2019-04-10" version="1">MLETLFGAEGEEMAKKLNQGEEVVPFLQSRSIKQLGERNFNKFLREKDTALVLFYQPDCHMCMSAKPHFMKAAINNPGRGRGYGIVDCSRETDLCDEEKIRKFPSFKLYVGGKLLGSYNQIPHYETLGEFVANAPAAPTNMNHKKHVRDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B1J1</accession>
    <name>A0A3S1B1J1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_022581</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001612">
        <property type="protein sequence ID" value="RUS69654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B1J1"/>
    <dbReference type="OrthoDB" id="10538385at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018746299" description="EGF-like domain-containing protein" evidence="2">
        <location>
            <begin position="30"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS69654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="33032" checksum="41B2FE172D481CC4" modified="2019-04-10" version="1">MIPSLKPVAYRTYCLLTMVSLFVFASGGAFPPMEEQYTLWMMDGNPNTCNNGDRYFVAVPTFVTKVTYIRVTFKVPGQIDKTSIRLYHVINGNEIIMTCSRNFTRQVDDLGKVYDVPCFTSKTTHSITFEGEGALQLCELLISPGRNIAPFQTPVVHFYENLENLTLALDGVIYQDRRSLQDCAYTYKTAYQLMYPGENEINMVLLFNSPEQYCCKDEVPGSCFVNWKPVCSKQENTPCKKGFKGDFCEEEEEEEEEEEEEEEEEEEEEEEEEEEEERGRRSNLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B415</accession>
    <name>A0A3S1B415_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_016673</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000730">
        <property type="protein sequence ID" value="RUS75548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B415"/>
    <dbReference type="STRING" id="188477.A0A3S1B415"/>
    <dbReference type="OrthoDB" id="102511at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS75548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="248" mass="27625" checksum="C916AF6FBA986C01" modified="2019-04-10" version="1" fragment="single">MDLPVVREGDPLSAQAAKLQSKICAFSLRTIALEIFATAGTPLNANFEKNLKGVFTGEGLMYWSKVVKQNLVAIGQSEEMDTEVVIYEQNLWDHPALNLLLAWKNFLITVSKFKVETVFQMTDANRTAILHDLLEGIKAQFKVGQLTELKVKLASISSALYFTLLKIWGRELCERQLSEFASSPRAVPTPVVALRHLTQALSESLEEDTFIPSVLIGLLGSISLTLQSCTHMLDCKISLLIDIIYLHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B4F4</accession>
    <name>A0A3S1B4F4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_012636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000440">
        <property type="protein sequence ID" value="RUS79611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B4F4"/>
    <dbReference type="OrthoDB" id="6148625at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS79611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="203" mass="22511" checksum="3348D67B3D053874" modified="2019-04-10" version="1">MAALIWRFLDMHYRNNSTSSYTTQAQSKDIDAVESQRLERIQAARRIKRVKSTNSRRSYSADSRNEDGGGGSSCLPTCLRGQRRSDKDRLYRSRQESSCSDFPSPDSNPPSYDGACRGRPRCNSGIEENAALLVDVTSSSHRSHSDKGMLYRSRQESSCSDFPSPDSNPPSYDGACRGRPRCNSGIEENAALLVDVTSSSHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B4Q1</accession>
    <name>A0A3S1B4Q1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_012428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000426">
        <property type="protein sequence ID" value="RUS79829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B4Q1"/>
    <dbReference type="OrthoDB" id="6159601at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018593283" description="Ig-like domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS79829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="38959" checksum="B5CBCDF3402622A9" modified="2019-04-10" version="1">MAAKSLFAAAIVLAIMVPDCLADVSVPPTTVKPRPSDMKPRLAFNPSTVESCVTTAVTLECSPKGGRTLAARIAAPKGNAVPDDNVAADNTSITSIKIFKQREADGPDDGEWEIFAEIGDTDSPSGPAADDPGVGVTGKVNGSAGESYLRVIWDVASDETYGVYRCDVMTAQNESESERSVVSTEPVALENPNNKVGIEEKLLKVLQEMQNERQKEEEWRGNVNERLERIAGMVNVLETFARGNAFKLNRIIMQVGDLEEPSSTAQPTTLPTSETTHTETTTMSSTEATITRNITPRRFASPTGEPDVAKKFVMLGVAGGRAAAATSAPVITTERRNKKRRRGDNRRRKNKKDKRRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B4Q9</accession>
    <name>A0A3S1B4Q9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_012379</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000424">
        <property type="protein sequence ID" value="RUS79853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B4Q9"/>
    <dbReference type="STRING" id="188477.A0A3S1B4Q9"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="3">
        <location>
            <begin position="64"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="303"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="349"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="440"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="623"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="305"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="360"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="440"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="628"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS79853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="655" mass="73615" checksum="B3EF33E85457507C" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B5P4</accession>
    <name>A0A3S1B5P4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_015561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000644">
        <property type="protein sequence ID" value="RUS76671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B5P4"/>
    <dbReference type="STRING" id="188477.A0A3S1B5P4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="695"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="730"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="769"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS76671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="800" mass="85793" checksum="CA743319173D362E" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B632</accession>
    <name>A0A3S1B632_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Isoaspartyl peptidase/L-asparaginase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_019266</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of a beta-linked Asp residue from the N-terminus of a polypeptide.</text>
            <dbReference type="EC" id="3.4.19.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-asparagine + H2O = L-aspartate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21016"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="EC" id="3.5.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ntn-hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000992">
        <property type="protein sequence ID" value="RUS72963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B632"/>
    <dbReference type="STRING" id="188477.A0A3S1B632"/>
    <dbReference type="OrthoDB" id="2262349at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008798">
        <property type="term" value="F:beta-aspartyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033345">
        <property type="term" value="P:L-asparagine catabolic process via L-aspartate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.30:FF:000001">
        <property type="entry name" value="Isoaspartyl peptidase/L-asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.30">
        <property type="entry name" value="(Glycosyl)asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188:SF43">
        <property type="entry name" value="ASPARAGINASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="111"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="134"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="9">
        <location>
            <begin position="82"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS72963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="23909" checksum="9F5AC1E2C70A1B14" modified="2019-04-10" version="1" fragment="single">TFLVGGFIGCSFPLFPRETSHCLLTSTGAREFMESQGIAAVPTTELVTDRARLELEQHREFASTLKHLVAPRSFAPSSSDCDTVGAVAMDANGNLAAATSTGGITAKMPGRVGDSPIIGSGAYADNTVGAVSTTGFGESIMKVCLARRVGELLEKGETAQEAAQHALDFMSRRVGGAAGVIVLSRGGDGGTCQVGHHFITENMAWAAIGGGQLRWGLDPGQENREILADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B6B0</accession>
    <name>A0A3S1B6B0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">OCEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_011343</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ELL/occludin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000368">
        <property type="protein sequence ID" value="RUS80872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B6B0"/>
    <dbReference type="STRING" id="188477.A0A3S1B6B0"/>
    <dbReference type="OrthoDB" id="6284217at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2670">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042065">
        <property type="entry name" value="E3_ELL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031176">
        <property type="entry name" value="ELL/occludin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019464">
        <property type="entry name" value="ELL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010844">
        <property type="entry name" value="Occludin_ELL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23288">
        <property type="entry name" value="OCCLUDIN AND RNA POLYMERASE II ELONGATION FACTOR ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23288:SF17">
        <property type="entry name" value="RNA POLYMERASE II ELONGATION FACTOR ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10390">
        <property type="entry name" value="ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07303">
        <property type="entry name" value="Occludin_ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144292">
        <property type="entry name" value="occludin/ELL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51980">
        <property type="entry name" value="OCEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="OCEL" evidence="8">
        <location>
            <begin position="388"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="111"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="300"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="300"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="346"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="364"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS80872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="502" mass="56297" checksum="6E76897E97C9C5E1" modified="2019-04-10" version="1" fragment="single">DGKASIQFQGNQGVISIPSHRGNPGQTFQISLSAIQGDQNGSFDCIQQKSNSSLESMGTMSYRVAVHATDDVYDRTRARMTMAEEESKKVCTKEIKPGGRFIGKKVKKVLPPGSLRIPPPVSKPTSLVSKAPGPSNLLGRQGIGHATLPTHLASSSPKEINSPSLPSLSGISRHSPTLSNVSSSNKSSGNLNSSGQQSRVLMSSTTKQSSGAINMPYRDRVIHLLALRPYKKPELIHRLQKDGIREKDKNSLAAILQQVAVMNKDNSYTLARGGWAYVRLEWPFYSDEDKVLLKRNLQQESRANHTSPAVSPASSNPESPGNNQKRSLADDVDDSSSNPNKRKRIAHSERKMVEEKPVSVVKPTLNQQSSPTANRENFDVNADDDSEPDYLREFKQIMDTKQRQMYKYEFNKEYTEYKELHQEVDAVARKFQNLRSQIDQTEEGTPDFEVLKQQVLEEYEAQRSDPKFMERKDRMNYLHHKLGHIKRLIHDFDHKGQAQACS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B8P6</accession>
    <name>A0A3S1B8P6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_013605</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000498">
        <property type="protein sequence ID" value="RUS78635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B8P6"/>
    <dbReference type="OrthoDB" id="6196550at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053248">
        <property type="entry name" value="Zinc_finger_MYND_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46533">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46533:SF1">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="4">
        <location>
            <begin position="48"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS78635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="131" mass="15149" checksum="732334FB4708A6D6" modified="2019-04-10" version="1" fragment="single">MATLGSSTSMVSENSELQSAGISGGRNKPIQYVVINLLTKRKHEKDRCELCEQVGSLMCSGCQVTFYCGIQHYNLDKDFHAILCSRVKELRKPIEFSAQAETRERWRKQKRIRMEELYKFTWKRGQADLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BD26</accession>
    <name>A0A3S1BD26_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_006721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000167">
        <property type="protein sequence ID" value="RUS85513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BD26"/>
    <dbReference type="STRING" id="188477.A0A3S1BD26"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS85513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="113" mass="13715" checksum="523A10BEE9E02D3F" modified="2019-04-10" version="1" fragment="single">APSTSLNLWFFLLRQATSLNLWFFLLRQATSLNLWFFLLRQATSLNLWFFLLRQATSLNLWFFLLRQATSLNLWFFLLRQATSLNLWFFLLRQATSLNLWFFILRQATSLNLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BD69</accession>
    <name>A0A3S1BD69_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_011428</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000372">
        <property type="protein sequence ID" value="RUS80807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BD69"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS80807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="144" mass="14961" checksum="264843C8AF4DA216" modified="2019-04-10" version="1" fragment="single">CCSTYNSLGIPALSPYCSTYNSLGISALSQCCSTYNSLGIPALSQCCSTYNSLGIPALSQCCSTYSLGISALSQCCSTYNSLGISTLSQCYSTYSLGISALSQCCSTYNILGIPALSLCCRTYNSLGISALSQCCSTYNSFGIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BDW2</accession>
    <name>A0A3S1BDW2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_013702</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000504">
        <property type="protein sequence ID" value="RUS78524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BDW2"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS78524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="101" mass="11068" checksum="B079FA77F96C72E4" modified="2019-04-10" version="1">MSIASEVNVTSVELRGKQSLKVGGRMSLKLKPCFSSCFWFTRVTIATSDMACFAREGFSTGLTGRVFNTVCEICVFFWGGPFVTVLVKALGCASFQYQIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BFB5</accession>
    <name>A0A3S1BFB5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_009857</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000288">
        <property type="protein sequence ID" value="RUS82405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BFB5"/>
    <dbReference type="STRING" id="188477.A0A3S1BFB5"/>
    <dbReference type="OrthoDB" id="431825at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039754">
        <property type="entry name" value="Esf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056750">
        <property type="entry name" value="RRM_ESF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202:SF0">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25121">
        <property type="entry name" value="RRM_ESF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ESF1 RRM" evidence="7">
        <location>
            <begin position="231"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="6">
        <location>
            <begin position="706"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="285"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="509"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="662"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="739"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="570"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="580"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="602"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="624"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="668"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="679"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="751"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="763"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS82405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="791" mass="91168" checksum="189C634A34A61095" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BGI9</accession>
    <name>A0A3S1BGI9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_004408</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000100">
        <property type="protein sequence ID" value="RUS87809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BGI9"/>
    <dbReference type="STRING" id="188477.A0A3S1BGI9"/>
    <dbReference type="OrthoDB" id="199913at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000033">
        <property type="entry name" value="Pancreatic triacylglycerol lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016272">
        <property type="entry name" value="Lipase_LIPH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002331">
        <property type="entry name" value="Lipase_panc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF173">
        <property type="entry name" value="LIPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000865">
        <property type="entry name" value="Lipoprotein_lipase_LIPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00823">
        <property type="entry name" value="PANCLIPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018729001" description="Lipase domain-containing protein" evidence="8">
        <location>
            <begin position="20"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="9">
        <location>
            <begin position="27"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000865-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000865-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS87809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="491" mass="54011" checksum="224BFCB6A91C51F9" modified="2019-04-10" version="1">MHQFSLLLVLSCLLCWADAHSIQKRSTVCYDHLGCFSNTGAFFSVQRPLTVTPAAPDSIRTLFRLYTREDRTSGPQLDARYLDNSHLINQWMFIKARPTKFIIHGFLDSPSIVTWLSDMKDELLKFGDFNVVIVDWSGGNLPPYTQATANTRVVGAQVALLVNLLMKNKGLAPSDFHLIGHSLGAHTAGYAGERVPGLGRISGLDPAGPYFEGTDKVVRLDPSDALLVDVIHSDAEPLIQLGFGLKQQVGHMDFYPNLGHDQPGCEPDPIRQLTEYGLIEGVSEVAACSHLRSYKFFTESINTPCSFQAFPCASEEDFKSNKCQSCQGSGCASMGMHADKSRPATNVKYFLSTADHAPFCQYHLEVTIKLGQGDTTSGERGNLALVVKGDKSISSKITLNSSPMMLSPGNVYRFSVGVTTDVGTVQAVDLSWHHVQSITDPLHWNILGTRHPKITVDEVDVFRIEDQADVHLCARSKQVETDHILQITNTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BGK8</accession>
    <name>A0A3S1BGK8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_008735</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LIMR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000241">
        <property type="protein sequence ID" value="RUS83485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BGK8"/>
    <dbReference type="STRING" id="188477.A0A3S1BGK8"/>
    <dbReference type="OrthoDB" id="5596951at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008075">
        <property type="entry name" value="LIMR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006876">
        <property type="entry name" value="LMBR1-like_membr_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12625">
        <property type="entry name" value="LIPOCALIN-1 INTERACTING MEMBRANE RECEPTOR LIMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12625:SF0">
        <property type="entry name" value="PROTEIN LILIPOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04791">
        <property type="entry name" value="LMBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01692">
        <property type="entry name" value="LIPOCALINIMR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="301"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="346"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="233"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS83485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="510" mass="57098" checksum="70B5E05929AF253D" modified="2019-04-10" version="1">MDYSEVTQQEQIFQNSVKNYIILGVLAITLYVLSYVTLCHFKKKADHEEMYAGEEDAVVYRIALWLCTVTLTVSVGAVLLLPISIISNEVLLLYPTSYWIKWLNSSLVQGLWNLVFFFSNLALFILMPFAYFFTEAEGFSGSRKGLMARVKEASLVLILLGLIVMGLFYIASTIISGDEKSKQTLQDVWYEHLPYLYSCISFFAVLALLMCTPVGVARMFTVMGRLIVKPQFLRDIEEELNTVRFEEENLLRKIKHRNGPAHLNNGHVTSVEELRESLKDIQKDRKALESRQHISFWRRNLCYPVVMLLLLAITVFSILIVVQNIIRLLLGTQSLPSSVSENALGIASLSSFGSVGAALQIAVILYLMVASVVGFYSLPYMKLLQPRPQETSMVQIIANCVVLLLLSSALPILSKTLGITNFDLLGKFGSMEWLRKFYIIFLYNAVFVVSTALCLVQKFTSPVWRGIYARLRVAFSRDGRGAGETTSVVGGASGVVGNGVGTKDDSFKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BJD2</accession>
    <name>A0A3S1BJD2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_002601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000050">
        <property type="protein sequence ID" value="RUS89680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BJD2"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS89680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="129" mass="15271" checksum="C340D64C590D58D5" modified="2019-04-10" version="1" fragment="single">HLDRMHHRCDTITIREIRTGPFLQHELYKTKVVVADGKDERTSEALTSLRSIKEIRLRDGDLGTQQKWVRQRVIIQNKSITKWITDKKILLDFRKLEMVRYPAVVPHECSHYVSIPLVFHFRVKISVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BJN0</accession>
    <name>A0A3S1BJN0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CTF/NF-I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_002386</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000046">
        <property type="protein sequence ID" value="RUS89856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BJN0"/>
    <dbReference type="STRING" id="188477.A0A3S1BJN0"/>
    <dbReference type="OrthoDB" id="10055441at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000647">
        <property type="entry name" value="CTF/NFI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020604">
        <property type="entry name" value="CTF/NFI_DNA-bd-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019548">
        <property type="entry name" value="CTF/NFI_DNA-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003619">
        <property type="entry name" value="MAD_homology1_Dwarfin-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11492">
        <property type="entry name" value="NUCLEAR FACTOR I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11492:SF8">
        <property type="entry name" value="NUCLEAR FACTOR I, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03165">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10524">
        <property type="entry name" value="NfI_DNAbd_pre-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00523">
        <property type="entry name" value="DWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51080">
        <property type="entry name" value="CTF_NFI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CTF/NF-I" evidence="10">
        <location>
            <begin position="42"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="349"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="409"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="557"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="673"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="499"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="557"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="675"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="736"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS89856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="750" mass="82329" checksum="2E94C8E6B77B6DE6" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BKA9</accession>
    <name>A0A3S1BKA9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_002072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calponin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000038">
        <property type="protein sequence ID" value="RUS90193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BKA9"/>
    <dbReference type="OrthoDB" id="21595at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000557">
        <property type="entry name" value="Calponin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF14">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00402">
        <property type="entry name" value="Calponin"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51122">
        <property type="entry name" value="CALPONIN_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="476"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="488"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS90193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="53024" checksum="E74E4A6A5BF405FD" modified="2019-04-10" version="1">MGDNSEENVDIGLNSGTNRFASQKGMRPFGAVRHISDIRADDLDKHGQEFLTPMTGTNKFASQSGMTGFGSVRHISDIRSDDIDPKSQGFLTIQTGTNKFASQAGTKGFGSVRHTTDIRADDLDIKGQGILTAQTGTNKFASQSGMKGFGAVRSVADIKGDGFSQEGQGIIPQQCGSNQYASQKGMGGFGATRHIRNTADNEATLESNSLVPAQYGTNQFASQKGISFGAVRHASDIKSCDIVQESQGVISPQSGSNQYASQKGMRGFGSVRHISDIRSDDVSREGQGHLSVQTGTNKFASQKGMTSFGTSRNVWDARAGDMSRESQAVLTMQTGTNKHASQAGMSSFGSTRHISDIRADDLSKESQSQLPLFQNNKDLASQKGMSIGSFRKIADIKTDDIDRKGQGVLTLQTGTNQFASQKGMTQIGGVRGIADTRMTSASQKSQGVLGLQTGWNKGASQKGMSFGGIRHICDTKVGKEKDKQGKPAANDANDANDAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BKM5</accession>
    <name>A0A3S1BKM5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_006293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000155">
        <property type="protein sequence ID" value="RUS85964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BKM5"/>
    <dbReference type="STRING" id="188477.A0A3S1BKM5"/>
    <dbReference type="OrthoDB" id="10017160at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF1">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS85964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="27297" checksum="448AA37FBF31CF31" modified="2019-04-10" version="1">MVLCYDKDVDGNAAAAAAAAAADDDDDDDDDDENNVDDDHDDHDDYDDDDDDGDDDDDDDDDYDDENDENNDVGEDLVPPHCLADSTSSSTASLNTLREESRLFLLKDPVADIILENIEGIRGPNKQPVARVRQDKAKDVVIQHDNARPHTSRQTQCALQQLELPTISHPTYSPDLAPSDFFLFPLLKKHLKGNHYETDAEIEADVRSWCRSQTPKFFADGMRKLVQRWRLCIERDGDYVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BM56</accession>
    <name>A0A3S1BM56_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome b-245 light chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cytochrome b(558) alpha chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Cytochrome b558 subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Neutrophil cytochrome b 22 kDa polypeptide</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Superoxide-generating NADPH oxidase light chain subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">p22 phagocyte B-cytochrome</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">p22-phox</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EGW08_005314</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">EC2010</strain>
            <tissue evidence="17">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="14">Component of the phagocyte NADPH oxidase core complex/cytochrome b558 complex, composed of CYBB (heavy chain (beta)) and CYBA (light chain (alpha)). Component of the phagocyte NADPH oxidase complex composed of an obligatory core heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic regulatory subunits NCF1/p47-phox, NCF2/p67-phox, NCF4/p40-phox and the small GTPase RAC1 or RAC2. Interacts with NCF1 (via SH3 domain). Interacts with SH3PXD2A. Interacts with DUOX1, DUOX2 and TPO. Interacts with NOX4; this interaction mediates superoxide generation. Interacts with calprotectin (S100A8/9). Interacts with GBP7. Interacts with NOXO1. Forms a heterodimer with NOX3 and is essential for activity and cell membrane localization of NOX3. Interacts with NOX1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the p22phox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000124">
        <property type="protein sequence ID" value="RUS86909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BM56"/>
    <dbReference type="STRING" id="188477.A0A3S1BM56"/>
    <dbReference type="OrthoDB" id="2445232at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007732">
        <property type="entry name" value="Cyt_b558_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15168">
        <property type="entry name" value="CYTOCHROME B-245 LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15168:SF0">
        <property type="entry name" value="CYTOCHROME B-245 LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05038">
        <property type="entry name" value="Cytochrom_B558a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="92"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="137"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00050017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RUS86909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="177" mass="19415" checksum="AF2E231EB1EFA888" modified="2019-04-10" version="1">MGGVEWAIWANENAVASAVVTLLGGILAVAGLYDMWQIGIYAIVIGLITLLLEYPRSKRKKGKHDHERRFQYPATVIVAKGGLFTRNYFIRFVFYLVISVPCCFSLQTVLGAVSFIITSFIYLTAGVKGEEWQPIQPTQAVQGPKVIAEPTRPPPRRPNLAVVGGGDHSSSPQDSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BNC7</accession>
    <name>A0A3S1BNC7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_004560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000103">
        <property type="protein sequence ID" value="RUS87719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BNC7"/>
    <dbReference type="OrthoDB" id="18937at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS87719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="311" mass="32702" checksum="FBA81A42CEBC3DC2" modified="2019-04-10" version="1">MEQMRKKPNMLKNFITNASFKAKKLPDDIDIVDEDYGNRLLAPVDEEGGSGLTGDHSVSRGLKARLKTKLGGGGDRARSRESNTGSVVTYRKDSPADLSYNNAGRRGDGETAATGGGGNHHHHHHHHHQLQQQQQQSPRGEAGEVGGGSSHKNNNGGSGGGGGRFWSVGGSRRDSDGTASSQGDRSGSKVKVDMLEMEPIKGRLPKDDDDADNNDGDEDGKDFYDDDGDVDNALKATAREGQSPRQGLWSPPSTPSPTSAPAHSPLLAASVRKSSREKTQALDSSGAGGDHHSQGPDSSAVNGKAVGINTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BPW8</accession>
    <name>A0A3S1BPW8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_003554</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000076">
        <property type="protein sequence ID" value="RUS88659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BPW8"/>
    <dbReference type="OrthoDB" id="10622608at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="553"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="700"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="753"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="764"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="848"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS88659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="903" mass="99261" checksum="B821958565A3D582" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BSF0</accession>
    <name>A0A3S1BSF0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PLD phosphodiesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_004593</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phospholipase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000104">
        <property type="protein sequence ID" value="RUS87670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BSF0"/>
    <dbReference type="STRING" id="188477.A0A3S1BSF0"/>
    <dbReference type="OrthoDB" id="1923775at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09107">
        <property type="entry name" value="PLDc_vPLD3_4_5_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050874">
        <property type="entry name" value="Diverse_PLD-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032803">
        <property type="entry name" value="PLDc_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10185:SF17">
        <property type="entry name" value="GM01519P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10185">
        <property type="entry name" value="PHOSPHOLIPASE D - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13918">
        <property type="entry name" value="PLDc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018707657" description="PLD phosphodiesterase domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="3">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="3">
        <location>
            <begin position="373"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS87670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="443" mass="50953" checksum="C015E7CA97E24D0E" modified="2019-04-10" version="1">MPSSGIKMLLTIMSMVFLVVTGEPQLIYKFDIPNLVKDFKCTETCKFTLVESMPENLTYPAFEPIMMSTYKAHKRILEKVKKTLYLSSCYWSLVGTDTDYHDYSSAEGEDILKHLYDLTKDGTISLKIAQNNTNKDTQMLESVGAEVRTPDFKRLLHYGILHTKMWVADNAHVYIGSANFDWRSYTQTKETGVLIEDCPCLGEDAAKIFEVYWYLGNPNSHIPQHWPANLSTAINVSNPAVLNYNDTNGEVYISSSPPQFCTTGRTGDIDAIVNVIRSAKKFIYISVMDYLPEILYAEPRVYWPIIDQELRNIAFNDGVQVYLLASHWQHTIEDMYAFLRSLDELHTTKFHKIDIHVKLFTVPADESQKKIPYSRVNHSKYMVTDQHAYIGTSNWSGDYFKYTGGVGFILKQSDGASSNLRQQLVQLFLRDWNSEYSKYVYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BSH2</accession>
    <name>A0A3S1BSH2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_001796</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000032">
        <property type="protein sequence ID" value="RUS90455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BSH2"/>
    <dbReference type="OrthoDB" id="3196451at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808:SF2">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="901"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="23"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="699"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS90455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="931" mass="103027" checksum="5ECFD90001C14441" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BTN9</accession>
    <name>A0A3S1BTN9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_003820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000083">
        <property type="protein sequence ID" value="RUS88424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BTN9"/>
    <dbReference type="OrthoDB" id="10564747at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS88424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="201" mass="22914" checksum="C6C1C256A15D0458" modified="2019-04-10" version="1" fragment="single">MDSLITKSKKMLNVDYQDPSSSQDFISSSIQYPSMCDSHPLSSRGNVKDLLASYLDVFETEAERTAQSSVASRKHRLETQLDFYSPRAWNEMKELMDSMAESYAQRFDQRAKRDKVSTISSYHIQEGIGQLGLLHPTLTCMNLVCIGHPLIQYDAFVGKSFLRKHKIKMGEIYVKPRDSTFLSDFMEFVQDMPKCGGDSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BTQ4</accession>
    <name>A0A3S1BTQ4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_017596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000812">
        <property type="protein sequence ID" value="RUS74642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BTQ4"/>
    <dbReference type="STRING" id="188477.A0A3S1BTQ4"/>
    <dbReference type="OrthoDB" id="542946at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="516"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS74642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="551" mass="63309" checksum="0A071F4AC369ED57" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BTW7</accession>
    <name>A0A3S1BTW7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_003672</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000079">
        <property type="protein sequence ID" value="RUS88572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BTW7"/>
    <dbReference type="STRING" id="188477.A0A3S1BTW7"/>
    <dbReference type="OrthoDB" id="6106109at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="97"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="168"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS88572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="302" mass="33216" checksum="357ECBC5AF4781C8" modified="2019-04-10" version="1" fragment="single">HTSFPLKVRVSAVSTLVVLRGHLFAVKSSFRAGFGPSPIQEIVNCRRLASVMMRSSALVWLGCLGVCLGILITWSGPADAASILHRRTRRQAATYSTVSCPQRFGQFELPGDCSRYIQCDSGVPSLQNCQPNLVFNAARGYCDFLANVPGCQLPQRGVTSSPSQEINYDICSTAPNGGNALDGYHVPHPQICNAFFTCSSNLLYAPCTFCPEHTYFSLPERRCIRNTTGDFASVCRSREYVSHQEKVFRQQDGMCRATNGAPSHIYDQGNSGIYPVNSNYQIVGPTYYQAQPIYPGRVLYIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BUD8</accession>
    <name>A0A3S1BUD8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras-associating domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_003291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000070">
        <property type="protein sequence ID" value="RUS88955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BUD8"/>
    <dbReference type="STRING" id="188477.A0A3S1BUD8"/>
    <dbReference type="OrthoDB" id="2428204at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061172">
        <property type="term" value="P:regulation of establishment of bipolar cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039269">
        <property type="entry name" value="ANKFN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21437">
        <property type="entry name" value="WIDE AWAKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21437:SF1">
        <property type="entry name" value="WIDE AWAKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS88955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="615" mass="68855" checksum="7D06A4DEA2CD13EC" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BZ11</accession>
    <name>A0A3S1BZ11_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_013597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000498">
        <property type="protein sequence ID" value="RUS78627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BZ11"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS78627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="433" mass="46114" checksum="09EB869DD17080B2" modified="2019-04-10" version="1" fragment="single">MSRSDWPMSAPGGVAYEEEWIADLQAGRGMTPELMQMDGDLEAAEARSADSMDDAIADELKSTTDVQEVCVRNPEAQTGATSATARDIEGKSSSTPPIVEGLSVAEDCSVGGRSPSLLRGLKPDSSWIRPVSLDLGPDVGESSTDDVGTDGFSQSAPCSAVVAPTFAPFAPPDPNPLDISQYQSEHAKSRSPSGGVTLYGVTESDSSDVTMADEPCPALINEKTQETFHSVLTEMSPATSPPRHLENKVMDTQRTTIDANLTTTEFKKNQTSAMQDKQNVKDLSPKPSCSNANDSNPKPSHIEGKTNTSPRSVEPGGEAKPRIEMGVRQYFFREKIPWSPGKVQKMREGINKTGHLILEGESEEEGGTGQETLAESDRGLDSPKGNLLQSQPSGLSQSQSCVELGYTLGSGSEDCVAVTESAGSSEFISLYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C0H0</accession>
    <name>A0A3S1C0H0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_012651</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="RQTK01000442">
        <property type="protein sequence ID" value="RUS79580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C0H0"/>
    <dbReference type="STRING" id="188477.A0A3S1C0H0"/>
    <dbReference type="OrthoDB" id="165342at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001706">
        <property type="term" value="P:endoderm formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01446">
        <property type="entry name" value="DSP_MapKP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008343">
        <property type="entry name" value="MKP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF530">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE DDB_G0271350-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01764">
        <property type="entry name" value="MAPKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="8">
        <location>
            <begin position="39"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="203"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="265"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="356"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="437"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="392"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS79580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="614" mass="69044" checksum="B0A65C89F7013688" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1CD17</accession>
    <name>A0A3S1CD17_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_002832</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000057">
        <property type="protein sequence ID" value="RUS89395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1CD17"/>
    <dbReference type="STRING" id="188477.A0A3S1CD17"/>
    <dbReference type="OrthoDB" id="8879391at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003937">
        <property type="entry name" value="K_chnl_volt-dep_KCNQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47735">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47735:SF9">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01459">
        <property type="entry name" value="KCNQCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="7">
        <location>
            <begin position="28"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="281"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS89395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="317" mass="35847" checksum="C85890F5474ECB5B" modified="2019-04-10" version="1" fragment="single">FLPIWSILTAGVCVFSFPVSLCGRVVQEIVMLLWILVELCLRVWSAGCRSRYQGKTGRLRFVRRPLCIIDMILVLASLGTLVAGSTQKRSKLLKYYIRIFTSFILRMVRMDRKGGTWKLLGSVVWAHRQELVTTLYIGLLGLVFSSYFVYLAEKDEPRRETDRQGGYNTTTYKPKFNNFADAIWWGVVTLCTVGYGDVVPATWGGKVIASVSAILGISFFALPAGILGSGFALKVQQQQRQKHLNRRRVPAANLIQCLWRCYAADEHSMSTATWKPHMIPCPSPTSERTPRANTSFVSRFSTRRRDRSSTMNSRDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H2M7</accession>
    <name>A0A3S1H2M7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospholipase B1, membrane-associated</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Lysophospholipase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Phospholipase A2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Phospholipase B/lipase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Triacylglycerol lipase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="44" type="ORF">EGW08_021245</name>
    </gene>
    <organism evidence="44 45">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="44 45" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="44">EC2010</strain>
            <tissue evidence="44">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Calcium-independent membrane-associated phospholipase that catalyzes complete diacylation of phospholipids by hydrolyzing both sn-1 and sn-2 fatty acyl chains attached to the glycerol backbone (phospholipase B activity). Has dual phospholipase and lysophospholipase activities toward diacylphospholipids. Preferentially cleaves sn-2 ester bonds over sn-1 bonds. Acts as a lipase toward glycerolipid substrates. Hydrolyzes fatty acyl chains of diacylglycerols with preference for the sn-2 position and of triacylglycerols with not positional selectivity. May also hydrolyze long chain retinyl esters such as retinyl palmitate. May contribute to digestion of dietary phospholipids, glycerolipids and retinoids, facilitating lipid absorption at the brush border.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = di-(9Z)-octadecenoylglycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38575"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:53753"/>
            <dbReference type="ChEBI" id="CHEBI:75945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="32">
            <dbReference type="Rhea" id="RHEA:38576"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40923"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28610"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:74669"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:40924"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="40">
            <text>1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2 H2O = sn-glycerol 3-phosphocholine + 2 hexadecanoate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:40975"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:72999"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="40">
            <dbReference type="Rhea" id="RHEA:40976"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41223"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:72999"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:41224"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="41">
            <text>1,3-di-(9Z-octadecenoyl)-glycerol + H2O = 1-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:39939"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75342"/>
            <dbReference type="ChEBI" id="CHEBI:75735"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="41">
            <dbReference type="Rhea" id="RHEA:39940"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="37">
            <text>1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O = 1,3-dihexadecanoylglycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40983"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75688"/>
            <dbReference type="ChEBI" id="CHEBI:77619"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="37">
            <dbReference type="Rhea" id="RHEA:40984"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O = 1-hexadecanoyl-2-(9Z-octadecenoyl)-glycerol + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40979"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:75585"/>
            <dbReference type="ChEBI" id="CHEBI:75688"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:40980"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>1-(9Z-octadecenoyl)-glycerol + H2O = glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38487"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75342"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:38488"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="38">
            <text>1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40915"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:34112"/>
            <dbReference type="ChEBI" id="CHEBI:64496"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="38">
            <dbReference type="Rhea" id="RHEA:40916"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41111"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:75466"/>
            <dbReference type="ChEBI" id="CHEBI:77623"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:41112"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="39">
            <text>1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O = 1-hexadecanoyl-3-octadecanoyl-sn-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41103"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:77623"/>
            <dbReference type="ChEBI" id="CHEBI:77624"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="39">
            <dbReference type="Rhea" id="RHEA:41104"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-3-octadecanoyl-sn-glycerol + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41107"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:75558"/>
            <dbReference type="ChEBI" id="CHEBI:77623"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:41108"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40811"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:73002"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:40812"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40971"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73002"/>
            <dbReference type="ChEBI" id="CHEBI:76084"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:40972"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40919"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:72841"/>
            <dbReference type="ChEBI" id="CHEBI:75158"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:40920"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="36">
            <text>1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38779"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:73001"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="36">
            <dbReference type="Rhea" id="RHEA:38780"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40911"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:73004"/>
            <dbReference type="ChEBI" id="CHEBI:73007"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="34">
            <dbReference type="Rhea" id="RHEA:40912"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="35">
            <text>1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40435"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="35">
            <dbReference type="Rhea" id="RHEA:40436"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + H2O = 1-octadecanoyl-sn-glycerol + (9Z,12Z)-octadecadienoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40927"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:75550"/>
            <dbReference type="ChEBI" id="CHEBI:77097"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:40928"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = 3-(9Z-octadecenoyl)-sn-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75824"/>
            <dbReference type="ChEBI" id="CHEBI:75938"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:42605"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="42">
            <text>2-(9Z-octadecenoyl)-glycerol + H2O = glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38491"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:73990"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="42">
            <dbReference type="Rhea" id="RHEA:38492"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:15802"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36231"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:30909"/>
            <dbReference type="ChEBI" id="CHEBI:36702"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:36232"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="33">
            <dbReference type="Rhea" id="RHEA:15178"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:12045"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 'GDSL' lipolytic enzyme family. Phospholipase B1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="44">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001290">
        <property type="protein sequence ID" value="RUS70995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H2M7"/>
    <dbReference type="STRING" id="188477.A0A3S1H2M7"/>
    <dbReference type="OrthoDB" id="10265800at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031526">
        <property type="term" value="C:brush border membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050253">
        <property type="term" value="F:retinyl-palmitate esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01824">
        <property type="entry name" value="Phospholipase_B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1110:FF:000005">
        <property type="entry name" value="Phospholipase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035547">
        <property type="entry name" value="Phospholipase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038885">
        <property type="entry name" value="PLB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325:SF31">
        <property type="entry name" value="GH22081P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325">
        <property type="entry name" value="PHOSPHOLIPASE B, PLB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="45" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 43" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="43">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018547267" description="Phospholipase B1, membrane-associated" evidence="43">
        <location>
            <begin position="31"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="44">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00033022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00045916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00048015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00048049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00048227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00048362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00048374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00048386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00048454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00048613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00048656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="ARBA" id="ARBA00048699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="ARBA" id="ARBA00048869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="ARBA" id="ARBA00048872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="39">
        <source>
            <dbReference type="ARBA" id="ARBA00048939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="40">
        <source>
            <dbReference type="ARBA" id="ARBA00049363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="41">
        <source>
            <dbReference type="ARBA" id="ARBA00049372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="42">
        <source>
            <dbReference type="ARBA" id="ARBA00049461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="43">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="44">
        <source>
            <dbReference type="EMBL" id="RUS70995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="45">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="331" mass="37256" checksum="CB26F6112C3D0617" modified="2019-04-10" version="1" fragment="single">MIALSEGRVMMSRLVLFSTTLCLCFLQVASFSSNDDFERRERLAMESILEMYRTNSTFAKLYDQWEKEQNEPLSAGEDFPCPLPRSNENPTSVHKLRPGDIKVLGAVGDSLTAARGASLGAFGLLTDFPELSWSIGGKGTFEKHVTLPNIIHKFNPDAVGASLSRNQRVFNKARSGAKSDEILNQTIALVEAIKADKDIDFENDWKVVTVFIGGNDICAMCTDYEFYAPENYQKRVKAGVDYLQANLPRTFVNLVELLNVEMVQELGTNLLCKTVHFLVCDCANRPGSEQAQKKLLEYKNEYQKKLGELADLKQYRTSDDFTVVLQPFYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HFR9</accession>
    <name>A0A3S1HFR9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_013766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000507">
        <property type="protein sequence ID" value="RUS78478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HFR9"/>
    <dbReference type="STRING" id="188477.A0A3S1HFR9"/>
    <dbReference type="OrthoDB" id="8757000at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22104">
        <property type="entry name" value="F-box_FBXO33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20933">
        <property type="entry name" value="F-BOX ONLY PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20933:SF3">
        <property type="entry name" value="F-BOX ONLY PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="4"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS78478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="466" mass="53172" checksum="F474F89C164B9A94" modified="2019-04-10" version="1">MAAGGNWASLPSVVLEHIFSKLSLKDRTNASSTCRRWREYLFLPQFWPVINFNLNYKGRQRSRFLSAKCSKFVKEATIEFNSTRVSQVWDCARLLDLLSRNGQVECICLRPSNSYFDGDKESLDSLLESLRQAVKRNRKLVHLSLGCAEVVLINSKDVLNLLVKYHSPNLQSLHLTSVKEDSSSYDLPHIGFDCVSVFSNLQALSLDYDFLTPNLMTSLADRQLGCPPLNNLCIHVHRVGQRQLTDNMWKRFVTANPHLELTVNLVHSMDGLHALLDILKPSMPLVHFRQYFCGDIRVASLNALGLHYPSTLRSLTIIEAIDLQPINYDTHDAEDPFVMLAWRCSRLESLKLFGVSVDQKNLVAIARLRPELCELSVPSCCVFWSEDDEDYYDSDEALFDLQYKVSESLGRDWQLLPEFCVPPAVFYHDADADNAYMEDLLADQSWDVLSQSFQQNIGKPQVYCSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HH93</accession>
    <name>A0A3S1HH93_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_012937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
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                <person name="Lundholm N."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">EC2010</strain>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <sequence length="1158" mass="128845" checksum="8541123C17F04FD6" modified="2019-04-10" version="1"> </sequence>
</entry>
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                <person name="Li J."/>
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                <person name="Nishiyama T."/>
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                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <dbReference type="Proteomes" id="UP000271974"/>
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</entry>
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                <person name="Pierce S.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="742" mass="79319" checksum="A4F2E5427FC3E011" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SJK2</accession>
    <name>A0A433SJK2_ELYCH</name>
    <protein>
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    <reference evidence="2 3" key="1">
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                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
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            <taxon>Euthyneura</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="RUS69989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SLF6"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS69989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="247" mass="27438" checksum="3E17480B4BB0E320" modified="2019-05-08" version="1">MYSGLGPVDQTVEGSEPPQKCCPSATWAVTPLLSLEGTETFSQSVRPKHQDTNNFLSRSHAGGQRDNNTMKPLDPVAFVTRQYQVFNRHRSRQSIYPIVREDNVPGEPIVSVTPRAGVLSSVAGDVAIRGHNSNTRSGNLWVKLATRHSPRVSLELLMLSLGWRLSVYEVSSGEGRRRLQDRRDKSPALQVWHSSRGVCGLGLRGHGIRCWELRARPRVQNILECSVSSRPVLFISQYQSVGGGRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SPD5</accession>
    <name>A0A433SPD5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">P-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_021146</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001275">
        <property type="protein sequence ID" value="RUS71085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SPD5"/>
    <dbReference type="STRING" id="188477.A0A433SPD5"/>
    <dbReference type="OrthoDB" id="5839090at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00111">
        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.110.10">
        <property type="entry name" value="Spasmolytic Protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000519">
        <property type="entry name" value="P_trefoil_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044913">
        <property type="entry name" value="P_trefoil_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF131">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 31 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00088">
        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00018">
        <property type="entry name" value="PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51448">
        <property type="entry name" value="P_TREFOIL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="P-type" evidence="9">
        <location>
            <begin position="95"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS71085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="777" mass="85885" checksum="B0BE5F9BCD95EC3B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SR35</accession>
    <name>A0A433SR35_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PLAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_020622</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001187">
        <property type="protein sequence ID" value="RUS71611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SR35"/>
    <dbReference type="OrthoDB" id="6631241at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="3">
        <location>
            <begin position="91"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS71611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="310" mass="34681" checksum="61EE82DA795C42CD" modified="2019-05-08" version="1" fragment="single">MKTDQMNQVKCRCFTNAPFSARQHDAVGDVIVYKPNAVDYHGPTIIPAMVVLISFVLYLYYSYWSYFQDIREQGCIHTHVIRDMYNPVSEDQFLVCISTGCLPGSGTDARVGFLLIGESGSLKYTVPEGDYCYSTGSEIWFVLSSDLNIGQIIGIMVNYDRHVNGSILYPWVLRGVVVYSMRSNHVITFRAYTAMGVQLTSIELPTVPHVYRRGGEALVRFWRMMRAQHTLGSVVFHRPGVGVTKGLSALIALLVVNLTCAVSIEILGAPTLVSHLKVLRHLKTSEHFPILLKVAPISLLCSMILNNVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SRU6</accession>
    <name>A0A433SRU6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Heat shock 70 kDa protein cognate 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_020278</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001135">
        <property type="protein sequence ID" value="RUS71965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SRU6"/>
    <dbReference type="STRING" id="188477.A0A433SRU6"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11733">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000020">
        <property type="entry name" value="Chaperone protein HscA homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000003">
        <property type="entry name" value="Heat shock protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000004">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000011">
        <property type="entry name" value="stress-70 protein, mitochondrial isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003520">
        <property type="entry name" value="PRK05183.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="630"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="530"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="637"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS71965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="656" mass="71249" checksum="4F0A7EC72D15F9A8" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SSZ1</accession>
    <name>A0A433SSZ1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_019832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001072">
        <property type="protein sequence ID" value="RUS72395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SSZ1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS72395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="283" mass="31164" checksum="A7340476AE0A0202" modified="2019-05-08" version="1" fragment="single">MRRQAGKQTGKPAKKAAAAAAGVSSPKPNGTNKSSKGRRSAKSASAGGTASAPNVASSASPAKRARPAPEKNNNNKKKDNKKKPAKASSGRESSAAYDDPAHGDKIRRTARGASDETESEQHRAALAKSEFLQADTFVHVKSEIRQAEFLERLKQQQQQQQQQHHHHQQFQQLRQHAQRADYDGAEEAVNHLNHHNQQQELQLQQQQQQQVLYQYPDQEAALMKRTQASGHQGSTLAHSIASSYRAESSPAERPGSVPQPEQSGSPLPRRNHQHPQQHQYPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SUF5</accession>
    <name>A0A433SUF5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitobiosyldiphosphodolichol beta-mannosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.142</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Asparagine-linked glycosylation protein 1 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Beta-1,4-mannosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">GDP-mannose-dolichol diphosphochitobiose mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">EGW08_019440</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">EC2010</strain>
            <tissue evidence="22">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes, on the cytoplasmic face of the endoplasmic reticulum, the addition of the first mannose residues to the dolichol-linked oligosaccharide chain, to produce Man1GlcNAc(2)-PP-dolichol core oligosaccharide. Man1GlcNAc(2)-PP-dolichol is a substrate for ALG2, the following enzyme in the biosynthetic pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>an N,N'-diacetylchitobiosyl-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = a beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13865"/>
            <dbReference type="Rhea" id="RHEA-COMP:19510"/>
            <dbReference type="Rhea" id="RHEA-COMP:19511"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57269"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58472"/>
            <dbReference type="EC" id="2.4.1.142"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:13866"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 33 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.142" evidence="3"/>
    <dbReference type="EMBL" id="RQTK01001017">
        <property type="protein sequence ID" value="RUS72803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SUF5"/>
    <dbReference type="STRING" id="188477.A0A433SUF5"/>
    <dbReference type="OrthoDB" id="614844at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004578">
        <property type="term" value="F:chitobiosyldiphosphodolichol beta-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000096">
        <property type="entry name" value="ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026051">
        <property type="entry name" value="ALG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036">
        <property type="entry name" value="BETA1,4 MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036:SF0">
        <property type="entry name" value="CHITOBIOSYLDIPHOSPHODOLICHOL BETA-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13692">
        <property type="entry name" value="Glyco_trans_1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="481"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00045071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00056362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00061237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00082785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="RUS72803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="511" mass="58928" checksum="B32818F66111E5EE" modified="2019-05-08" version="1">MSFSLDILFYTPFVFVFLYLLTNFLAKTPRNVCIVVLGDVGRSPRMQYHALSFAKEGFRVYLVGYRGSQPHEAILQNENIQLHHVKEPPAFLVYFPRLLQYILKVIWQSTMLLWTLLLLPKSSSLLIQNPPSIPTMLVSYVVCWLRRSELVIDWHNYGHTILSMALQPSHPLVKFSRWYEKKCARLSTYNICVTNAMKEDLEKNWNVRSVSVHDRPPDHFSPIEETRQHDFFFRLSKQYPVFGSSIKGCTKFTKMDSSGHVLKLLKRPALIVSSTSWTEDEDFSILLETLTEYDKSERCDDLTDIVCVITGKGPLKEFYRKKIQKQNWRKIEFCLPWLEPEDYPLLLASADLGVSLHTSSSGLDLPMKVVDMFGSGLPVCAANFKCIDELVKHNENGLVFNDNLELLEQLKTLLKGFPHNSKQLEIFRKNLLPFQQLRWHGQWKRLVLPIFQVIGGVETPSYTFPGLTRYPGWKGWGDAGTDCDPDSKKNQDGDVAMNDNDGCEAKYKKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SZ00</accession>
    <name>A0A433SZ00_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_017707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000822">
        <property type="protein sequence ID" value="RUS74535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SZ00"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS74535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="190" mass="19971" checksum="B3255C67E80F399D" modified="2019-05-08" version="1" fragment="single">MYKHRKKLSKDESGDSSRPSTSNSGRSSQISNSSSKTTSRSTNNETKLQSDGHKDISPGVSTNAVSYGEAGGVSAGEIRPKSKEIKVKTKQIDGSETGSGKGKAAEVPKDLGKESSTGNKADNKQVTSELKSVNLDSKPVASQQSNIPQQLSDKSQLMTSQKMKVTSTVVPSPTPPPPSLPQQVVPPPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T2B4</accession>
    <name>A0A433T2B4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_016549</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000719">
        <property type="protein sequence ID" value="RUS75683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T2B4"/>
    <dbReference type="STRING" id="188477.A0A433T2B4"/>
    <dbReference type="OrthoDB" id="10684656at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.700">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS75683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="451" mass="46944" checksum="D3C66C2E36D5A789" modified="2019-05-08" version="1">MRAEFYIESQVLLVSGILKPAGKCFNGILKWLIVGGLVGLVGLAGILVGLHLSGNLSPDTQKANESDPVKDAMTEVADDAVNAAAGAADTVVDAAANVADALGDAASSAGDLWGEMVDDVYEDFKSSSGSLEDLAETEVDDVGEIDDDGADDDDNDDKKGGVSNSKESKSDDKDENDDSDDDDDNDFDGSLGGIAERLREILKDTVGALGDAKVDAGDVNEALDEGAEGVEEGLENVEEGVKEGMENIKEGVENIGEGVEEGLENAKEAVENVQEGLEDAAEGSSSSIDSLEPKSEDLDLGDKLEHPEGLQDLSEHLGSMGEGLLEKLGELGERFKALGKGIGEGISEHLNDMSESLSDHVFEGFSDNVDSISEGFGSMAEGLGDAFDMEGFGGGDLDDGMGMMLMAKALSGERVRSHNIKTNTNPWAAILANSGNPYSAMAVAQRPIGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T2G3</accession>
    <name>A0A433T2G3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Saccharopine dehydrogenase NADP binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_016509</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000716">
        <property type="protein sequence ID" value="RUS75727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T2G3"/>
    <dbReference type="OrthoDB" id="10268090at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000178">
        <property type="entry name" value="Saccharopine dehydrogenase-like oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="2">
        <location>
            <begin position="9"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS75727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="424" mass="46581" checksum="7AE0973EFCF0B2F9" modified="2019-05-08" version="1">MTSQKFDLVIFGATGFTGQFVVDEVCRVAEEENLTWAIAGRNMAKLQKVLSEASCRTDMNLLETPILIADTSSKSSLDEMAKQAKVVLNCVGPYRFYGEPVVKACIENGAHHLDISGEPQYLETMQLLYHSKAKENDVLIIGATGFDSVPAESGILYLQDKFKSGQLASVESFLSIQTGPAGVGINFATYESAVHGLSNAKELVSLRKSLYPEPMPKVQHPLPKRSSLFFSDEVKKWCLPFMGSDKSVVYRSIRSQFSAGVLKSPVEFYPYMCVSSLFSAVKFITFGLIFSFLCRSSLGRWLLLNFSHILTLGKVKKGGPSREQIDGTSFTMTFVGHGYDSLELMNNGGKPNRQVTARLAAPELGYVTTPICMVQCAAIVLKEKDKMQHKSGVLTPGAAFYGTSLIERLNNHNVKIETVSDTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T350</accession>
    <name>A0A433T350_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyl-ACP thioesterase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_016232</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000694">
        <property type="protein sequence ID" value="RUS75987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T350"/>
    <dbReference type="STRING" id="188477.A0A433T350"/>
    <dbReference type="OrthoDB" id="6152485at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049427">
        <property type="entry name" value="Acyl-ACP_TE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34487">
        <property type="entry name" value="ACYL-ACP THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34487:SF1">
        <property type="entry name" value="ACYL-ACP THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20791">
        <property type="entry name" value="Acyl-ACP_TE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-ACP thioesterase-like C-terminal" evidence="2">
        <location>
            <begin position="71"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS75987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="227" mass="25948" checksum="4EBD820DE19E1433" modified="2019-05-08" version="1">MQLYFHRTEKRFRGRPTTTLPVTINKDLSQIQDNLSLKSTDDLEYLRTLAQDRNQRKSLTKQIVEIAEASRSDESEISQSQVLLSDIDGNKHTNYKVYIRGCYDALQHAITTKEMLRPIKIESATDGPSGEMTGTNPNVGNPSASANDSHKEVLPKWLTADIMKKGIKTLRAKFIKESLCGEEVTTHVWQERDKPLWVFFSMERETTNGNQVLFEMSLEYFGLMSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T5T0</accession>
    <name>A0A433T5T0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_015326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000624">
        <property type="protein sequence ID" value="RUS76923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T5T0"/>
    <dbReference type="OrthoDB" id="6160622at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS76923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="555" mass="60335" checksum="718F33BB6A5B4B0C" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T6B5</accession>
    <name>A0A433T6B5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isopentenyl phosphate kinase</fullName>
            <ecNumber evidence="2">2.7.4.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_015164</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>isopentenyl phosphate + ATP = isopentenyl diphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:33963"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:65078"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the isopentenyl phosphate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.26" evidence="2"/>
    <dbReference type="EMBL" id="RQTK01000612">
        <property type="protein sequence ID" value="RUS77081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T6B5"/>
    <dbReference type="STRING" id="188477.A0A433T6B5"/>
    <dbReference type="OrthoDB" id="1934954at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102043">
        <property type="term" value="F:isopentenyl phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024192">
        <property type="entry name" value="Fosfomycin_R_FomA-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040647">
        <property type="entry name" value="IPPK_Arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654:SF1">
        <property type="entry name" value="ISOPENTENYL PHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016496">
        <property type="entry name" value="Kin_FomA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/glutamate/uridylate kinase" evidence="12">
        <location>
            <begin position="8"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="10"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="11">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR016496-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR016496-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS77081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="283" mass="31114" checksum="2A4DE28DD11B6CA0" modified="2019-05-08" version="1">MVPTIDAIIKIGGSAITEKDELETLKSSALPKAFDVIRKCRESGATIIVVHGAGSFGHHHAKKFEISKGISSSINEEALKKKMMGFSLTRQSVQKVKSSHWYEQNIKCIKYHCSRISWRTNKHEPVGWPRETICLLLKQNFVPVLHGDACMDESDGFSILSGDTIIKTLCSHFDVRRAVFLTDVAGVYDRPPSEPDAQLLKSIFVKDDGTVDQVIGTSQSKNDVTGGMLLKLNTATKIVSQTRGRCLVFVCALDSCDSCNIICSAESTEADLLNTQCTKIMMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T6F2</accession>
    <name>A0A433T6F2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_015151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000611">
        <property type="protein sequence ID" value="RUS77096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T6F2"/>
    <dbReference type="STRING" id="188477.A0A433T6F2"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS77096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="223" mass="27246" checksum="ADDFAC3606969D20" modified="2019-05-08" version="1">MDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T7V9</accession>
    <name>A0A433T7V9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_014531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000559">
        <property type="protein sequence ID" value="RUS77695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T7V9"/>
    <dbReference type="STRING" id="188477.A0A433T7V9"/>
    <dbReference type="OrthoDB" id="43122at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS77695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="100" mass="11665" checksum="F2C4A5B7F0329CD2" modified="2019-05-08" version="1" fragment="single">MFCFLFTITRKLNIDLNISITRRLNIDLNISITRKLNIDLNISITRKLNIDLNISITRKLNIDLNISITRKLNIYLNISITRKLNIDLNIADNLECSLCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TBS8</accession>
    <name>A0A433TBS8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_013217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000477">
        <property type="protein sequence ID" value="RUS79006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TBS8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS79006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="243" mass="27903" checksum="A8D0BC96FE141CA4" modified="2019-05-08" version="1">MLTKVSTLLRRFTCDSLEHSTKSSPERRFVTLLASPTIPFSDLLIAKTLSFATFLSASLIIWKGDQLCLAVEPKGVVTPRHCQRKKWAWLHQDIVKERRGRGYTKTLSGKEIGVVITRHCQGKKRAWLHQDIVRERRGRGYIKTLSGKKRAWLHRDIVREEEGVVTPGPFQGKKRAWLHQDIVRERKVYGACVLTNVTYRKKRWGPNFRSLQQDSSTLSALNQSIFVVPSPLNKAVLFLRLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TD07</accession>
    <name>A0A433TD07_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_012909</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000458">
        <property type="protein sequence ID" value="RUS79324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TD07"/>
    <dbReference type="STRING" id="188477.A0A433TD07"/>
    <dbReference type="OrthoDB" id="6137149at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22755">
        <property type="entry name" value="OTU_CeDUB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF7">
        <property type="entry name" value="OTU DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="70"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS79324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="442" mass="48975" checksum="B2BD7C1E2CB9149F" modified="2019-05-08" version="1">MSRWSRRGQCYGRMVRPGHSDRHREESPVFRPIGVRWQERQCRRLGLPLVTPLQLARPRPAPSLRHREPSLVIEIGGDGNCLFRCLSLNVVEMQYKCLVKMVITGSENHHTQVRQRIVSHIAQNCKAFSALLPESPRRSANGSRQEHADACAQYLSTSKMAAGATWGSDVEILAAAHLLRTRIFVYTLHGPAWQWVEHGLELTDPGRKPSAESVYLVHTDLVHYDLVEDTTPVPPADETKGVSRAQGLRSQNLDRHIGQGVGAKAARSRGYSVSCTRADTSPTVNQQHSSSSCYSSSCSSSTCSIDGKPSCGESESVGSAQASQRNASVPCSRQRRPGLSCRDGTRFVVPCRDGRQRLAVHTVGRPKAYGHTHRNNNNSFLNARHMNPTRTSVNCHTAVCCRGLKKSLGPKARSSLTPYRRCSRNMQDTNSNKENIQPKVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TDE9</accession>
    <name>A0A433TDE9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_012625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000439">
        <property type="protein sequence ID" value="RUS79625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TDE9"/>
    <dbReference type="STRING" id="188477.A0A433TDE9"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48209">
        <property type="entry name" value="AGL056WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48209:SF2">
        <property type="entry name" value="FI24008P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS79625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="413" mass="45691" checksum="854CE6D79A79B9DF" modified="2019-05-08" version="1">MMNSKSRKPTLAGAGTLTAPELDTQTEPRPLDSGCFESRIKMEMFLSFSAYTINMVASKGVKPFASKMTFKPQFRVFVLKWRSLISSLLGASYSPCLFNQHRTDETPEPQDSIPIRKQNADRAVCFSGGEICSAESQTMSRKGRQSGVKIHTLRTALPTHIATKHEQCETKYCTELCTNTAILGLHENGGDDNDDDGDDDDDEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDGSGDDFILPVGAFRRLRAHPKRGLRTRSQVTQNGDKPRENSARDFSSSSATKIWSCLPTGLLSEQISRLWGTRRPITSVLQGGSYTVTEPKTYKILQLFMCYHTKTDTQRQGGDILNSVSVCHIIQTPTQTVEKILHGDGPTDLAAQVIMEPSQAANRGGQSGARSRTITIYKRTCCPSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TE15</accession>
    <name>A0A433TE15_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Ionotropic glutamate receptor C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">EGW08_012373</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">EC2010</strain>
            <tissue evidence="19">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000424">
        <property type="protein sequence ID" value="RUS79847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TE15"/>
    <dbReference type="STRING" id="188477.A0A433TE15"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000024">
        <property type="entry name" value="Glutamate receptor, ionotropic, delta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="416"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Solute-binding protein family 3/N-terminal" evidence="16">
        <location>
            <begin position="15"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="17">
        <location>
            <begin position="17"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="18">
        <location>
            <begin position="25"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="463"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="504"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="330"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RUS79847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="516" mass="57068" checksum="6FBF47CAF4D7E433" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TH53</accession>
    <name>A0A433TH53_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_011336</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000367">
        <property type="protein sequence ID" value="RUS80900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TH53"/>
    <dbReference type="STRING" id="188477.A0A433TH53"/>
    <dbReference type="OrthoDB" id="6242193at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="294"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS80900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="441" mass="51045" checksum="2404CEB0C487FE51" modified="2019-05-08" version="1">MSGYATLKTKLKVHRDKAGRPSFKFNVNCLKEKVKAEEFRVEVKNKFEMLSLLPEDAVDQHWQQLREVWKTACSTVLGKKTRKHKEWLTTDTWSLITERKVLKDKINATQDVEQKRELQTSYWDLNRQVKKSARQDKRTFIEELTTEAETAAGQRNMKRLYDITRTLSGKKNSSNRPIKDKEGNTIPGEEDQRRRWAEHFKETLNRPAPSTPVDIPSQTEPLSINTNAPSKAEITNAIKSLKSGKAAGPDGIPPEALKADIQTSTEMLHPLLNKTWEQECVPEDWKKGYLVKLPKKGDLSSCNNWRGIMLVSIPGKVLTRIMLERLKTALDKKLREEQAGFRQERSCTDQIATLRIIIEQSLEWQSPLYTVFVDFQKAFDSVDRETIWKLMHYYGIPKKFITIIQTLYEDATCQVIHDGKLTEPFNFKNWAYDFKKIGAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433THX4</accession>
    <name>A0A433THX4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_011102</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000354">
        <property type="protein sequence ID" value="RUS81116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433THX4"/>
    <dbReference type="STRING" id="188477.A0A433THX4"/>
    <dbReference type="OrthoDB" id="786951at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032922">
        <property type="entry name" value="SON"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46528">
        <property type="entry name" value="PROTEIN SON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46528:SF1">
        <property type="entry name" value="PROTEIN SON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14709">
        <property type="entry name" value="DND1_DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="G-patch" evidence="4">
        <location>
            <begin position="897"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="3">
        <location>
            <begin position="968"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="328"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="692"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="383"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="410"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="472"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="502"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="532"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="560"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="591"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="627"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="698"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1011"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS81116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1011" mass="114457" checksum="595533D631095F99" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TI63</accession>
    <name>A0A433TI63_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aquaporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_011031</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000350">
        <property type="protein sequence ID" value="RUS81201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TI63"/>
    <dbReference type="STRING" id="188477.A0A433TI63"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS81201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="25314" checksum="0EE6F3EBA63E2447" modified="2019-05-08" version="1" fragment="single">MSVRSLPALVRGDNDRRVSRESRWTTLLTQEKNDLLSVSLWRAAFGEFVGTGLLCTFTIGFGMTPEGGTPPPVLQIAIAVGFFISVLITALANVSGAHVNPCISLAFFINGHCTFARMMVYSVFQALGAVAGTGLLKFIAPSGHLGSLGLIQPTPGVSDSQAVMVEMVITFLLTFNTVAMIDSKRTDVQGSVPLQVGLIVAVNIFFANSVSGACMNPVRAFGPAVVTGNYGRLHVSSNSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TLB0</accession>
    <name>A0A433TLB0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_009891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000290">
        <property type="protein sequence ID" value="RUS82338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TLB0"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019103359" evidence="1">
        <location>
            <begin position="22"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS82338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="528" mass="65655" checksum="186D73A3891417AA" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TN94</accession>
    <name>A0A433TN94_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_009228</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000262">
        <property type="protein sequence ID" value="RUS82991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TN94"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS82991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="103" mass="11096" checksum="F69782BBFA530A2B" modified="2019-05-08" version="1">MTTRPAAESAESFNCHTILTPGGGFNQADFNCTLFGDEALTEHYSETRPTEGSPRCPRPALSPECPVQVSTKTVANCHCSVEGGKNYTANDALRYSVTHSLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TP73</accession>
    <name>A0A433TP73_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_008848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000245">
        <property type="protein sequence ID" value="RUS83382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TP73"/>
    <dbReference type="OrthoDB" id="6212861at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS83382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="250" mass="25549" checksum="8615F04621B9A12E" modified="2019-05-08" version="1">MTCILAPYVCNPQESGVSVSITLSVCLSVCLSVCLCLSISLSLCLSVCLSAAATALAPSVVSSIRQKSETDRALPPDPARLAGTAPHSFGGRVVSGCDVTQPYATFDDHPSAGNNTRSANLRDFTSRINNCSLAVPTCGIEPAHCQPRSGSFGWIAFSGRSASFGDGVPRRSHSDALRAELAVGSHALHGSRPPGPGVRPRDLTEQAQDGLGLWGEDTCLVCGGLHFASSISSPFLSCGAGGSAATGSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TTV8</accession>
    <name>A0A433TTV8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_007243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000186">
        <property type="protein sequence ID" value="RUS84998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TTV8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="322"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS84998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="493" mass="54890" checksum="4175E47AA265DF31" modified="2019-05-08" version="1">MATEHSEQKGISISQNLASPHRHIATVNQEETVFQTHKHLHAHVHTHSHTRLTSGKTQRHQLTHCVIAANSTAAEDAGGYTDEKCERTNKSCSRATPKQTYSVRSVVKSNGDSKEDAWFKSFVEVQSGDHHTESCGEQKLDTCSGVNCYDQQLDLELSMLAKDLDYDVCADDPVPSVAVSPGAVVFTAGAMRAIVEKIFSGAHASSPATETGPENSVENFLSNITGARKPTRKLSDLDINRVIEWGETALTRQSGQSFHLSKPGLSPRPYGSSNNQCRERQDRRSRRCASDCPRCKLRQHWQQNLQHSLSLRQQREQRHRQQQYQQKQQQQQQQPQYTGTISQHHPRDCEHELTRQTSQGKPQTVLREMQQTFLQLKPPTPITDDSPVLYLDNKASISEAKAPYLYISTSTELGEDRHPPASALRLKQLRAARKGGRACVGRLRATRLACAQGESTNPQQQRFSLATLPQGSTATALLIGYAFSGRTTTLLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TV28</accession>
    <name>A0A433TV28_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Queuosine 5'-phosphate N-glycosylase/hydrolase</fullName>
            <ecNumber evidence="6">3.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 6">Queuosine-nucleotide N-glycosylase/hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_006774</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>queuosine 5'-phosphate + H2O = queuine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:75387"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17433"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:194371"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5 6">
            <dbReference type="Rhea" id="RHEA:75388"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the QNG1 protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="6"/>
    <dbReference type="EMBL" id="RQTK01000169">
        <property type="protein sequence ID" value="RUS85441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TV28"/>
    <dbReference type="STRING" id="188477.A0A433TV28"/>
    <dbReference type="OrthoDB" id="416777at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019438">
        <property type="entry name" value="Q_salvage"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314:SF0">
        <property type="entry name" value="QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314">
        <property type="entry name" value="QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10343">
        <property type="entry name" value="Q_salvage"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS85441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="348" mass="39716" checksum="BBDAC485A66EF541" modified="2019-05-08" version="1">MDGVLNPRDAGRFISENSKDVSIEDAGVQKVANMIYEKSKTGEFNMKMWRNHELNPQTMDEDAVNWVFVSAVLNFSFWSEKESDRYAVKYKDKIHTGYWSLCAAMNRALDEALKITTASFYSTITMDQMKHIFRSDSDTKMPMLEERQMALVEAGGVLMKKYEGSFANVVKQSDKSAQSLLRLILEDFPSFRDVAEFGGKRVGLYKRAQILVGDVWGCCEGQGLGEFTDINTITMFADYRIPQALVYFGALKYSENLMDTLKKCQVLKSGDRLEVEIRGVSLWACELIRDSIAAKLSAETSKENGHQDKAEVAQVNAILVDHYLWDLRREMADEMSHIPFHRCRGIYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TXC9</accession>
    <name>A0A433TXC9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_005953</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000144">
        <property type="protein sequence ID" value="RUS86261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TXC9"/>
    <dbReference type="OrthoDB" id="5983572at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058831">
        <property type="entry name" value="LolA-like_dom_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36902">
        <property type="entry name" value="ENRICHED IN SURFACE-LABELED PROTEOME PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36902:SF1">
        <property type="entry name" value="ENRICHED IN SURFACE-LABELED PROTEOME PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25898">
        <property type="entry name" value="LolA_2nd_metazoa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019194554" description="Apple domain-containing protein" evidence="3">
        <location>
            <begin position="41"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="957"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="4">
        <location>
            <begin position="757"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="993"/>
            <end position="1013"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS86261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1013" mass="113281" checksum="B2D322CE59352F40" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U0L4</accession>
    <name>A0A433U0L4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosomal RNA-processing protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_004968</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. RRP8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000115">
        <property type="protein sequence ID" value="RUS87288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U0L4"/>
    <dbReference type="STRING" id="188477.A0A433U0L4"/>
    <dbReference type="OrthoDB" id="10258825at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005677">
        <property type="term" value="C:chromatin silencing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046015">
        <property type="term" value="P:regulation of transcription by glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2150:FF:000001">
        <property type="entry name" value="Ribosomal RNA-processing protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000068">
        <property type="entry name" value="Ribosomal RNA-processing protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2150">
        <property type="entry name" value="Ribosomal RNA-processing protein 8, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007823">
        <property type="entry name" value="RRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042036">
        <property type="entry name" value="RRP8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05148">
        <property type="entry name" value="Methyltransf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="459"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS87288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="707" mass="78787" checksum="3EDD78872AA6715D" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U130</accession>
    <name>A0A433U130_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_004764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000109">
        <property type="protein sequence ID" value="RUS87510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U130"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS87510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="348" mass="34298" checksum="174EEA55AE328C51" modified="2019-05-08" version="1">MSPVVGCHTLFQQTPPPLYGYGGRVTDALLVTLVQVLISGKANPLLNPVHIEERSAGRGQYFRLLAAVSVQEISCDQIVLEYSGARSAAFKDMGTRVPDNQLILIASHVDVVNNGGSIAAVTSTLSVVAVFVVVDVAVRNAASPAVVVFLEVFTDTLMSGSEAGCASPVFVVVAVVVVVVGVVVVVVGVVVVVVVGVVVVVVVVVGVVVVVGVVVVVGVVVVVGVVVVVGVVVVVGVVVVVGVVVVVGVVVVVGVVVVVGVVVVVGVVVVVGVVVVVGVVVVVGVVVVVGVVVVVGVVVVVGVVVVVGVVVVVGVVVVVGVVVVVGVVVVVGVVVVVGVVVVVGVVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U6T8</accession>
    <name>A0A433U6T8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_002721</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000053">
        <property type="protein sequence ID" value="RUS89533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U6T8"/>
    <dbReference type="STRING" id="188477.A0A433U6T8"/>
    <dbReference type="OrthoDB" id="9984784at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="197"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS89533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="256" mass="28143" checksum="E0061AA84656E315" modified="2019-05-08" version="1" fragment="single">MATPDQKLHKAVRENDMTTVVSLLNSGVNINCLFYGWTPLQLAIENGLQEMAIFLISKGCDTNQHDKSSKSPFEEAVVKKEAKVVEALVTNGVSATQNLSSGDSALCYAVELGCTDLVKALLNDSLSDGERERSGFICLLLSFQHQHNTLMDLLNQSTGADLNVVHIDNNNFTPLIAAVACDNEEINMADVNVQDTDGWTPLWHAYSNSNEEICELLLCAGAQTDLTNVEGKTVIQEANENEDDDFIEIFNKFKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UCB8</accession>
    <name>A0A433UCB8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_000890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000013">
        <property type="protein sequence ID" value="RUS91373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UCB8"/>
    <dbReference type="OrthoDB" id="6190465at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS91373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="123" mass="14147" checksum="FEB225DD4C155EDF" modified="2019-05-08" version="1" fragment="single">LERKCVGDITFPDDEPFVSTEVKDFLEEVSRGSLQTPHLSTYELTRFGLSFLKKAKHRVCCSQRLIRILSTMGEFYDYEISQSKKLLRYLANVLLHGLHNLEKDHQKNAALLQTSIKKACMAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z6J3</accession>
    <name>A0A3S0Z6J3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">XK-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_021809</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the XK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001410">
        <property type="protein sequence ID" value="RUS70433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z6J3"/>
    <dbReference type="OrthoDB" id="6136301at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902742">
        <property type="term" value="P:apoptotic process involved in development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043652">
        <property type="term" value="P:engulfment of apoptotic cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070782">
        <property type="term" value="P:phosphatidylserine exposure on apoptotic cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018629">
        <property type="entry name" value="XK-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050895">
        <property type="entry name" value="XK-related_scramblase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024:SF6">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09815">
        <property type="entry name" value="XK-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="503"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="543"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="573"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="586"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU910716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS70433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="609" mass="70457" checksum="5C9E149E2B2BD9DD" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z955</accession>
    <name>A0A3S0Z955_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_020014</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001095">
        <property type="protein sequence ID" value="RUS72226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z955"/>
    <dbReference type="STRING" id="188477.A0A3S0Z955"/>
    <dbReference type="OrthoDB" id="10053709at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042813">
        <property type="term" value="F:Wnt receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035567">
        <property type="term" value="P:non-canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07066">
        <property type="entry name" value="CRD_FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FZ" evidence="6">
        <location>
            <begin position="67"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="190"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="72"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="80"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS72226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="291" mass="32705" checksum="449C9E983CCBB533" modified="2019-04-10" version="1">MSGKALPVVVSKTSNSDIKKVERKEKKSKKAGLKKRKGYYSEKRWKKGRMLADQPNIYARPGQRRSGRVKGCLPFESDFCPNMPYNMGGFPSLLGHRNPDQANEGLSKLTPLMRTGCSARLHDFLCGVYFPQCIERKVFAPCRSLCEEVQADCLADLIKLGFAWPQRLRCHNFAEDSDCFGKGPEAIIKPPRGLVNKGKGSTSIDKKPSPPRKEKKKPSKPRDQSKTTDVSPAVVEMMNAKFMNPFMDWLFSSTKLNKDQARLAQEQAEVAKLTEQKLDLEISNLKNGKAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z9Q1</accession>
    <name>A0A3S0Z9Q1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_022263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001523">
        <property type="protein sequence ID" value="RUS69977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z9Q1"/>
    <dbReference type="OrthoDB" id="6208868at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS69977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="125" mass="13907" checksum="8DB8590DFFC43231" modified="2019-04-10" version="1" fragment="single">MDNVADALGSNLKGSNQRLGVKTDHVQMGVELHTVTSNMSFDLGQDKHATFHLATGDTGILGDESVQGDFQVYNTNPYAFSTKNVYGDLPVIKVRFMRKKKDNDTAEGETTTHKHFRFEKPADIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZBI4</accession>
    <name>A0A3S0ZBI4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ISXO2-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_021092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001265">
        <property type="protein sequence ID" value="RUS71147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZBI4"/>
    <dbReference type="STRING" id="188477.A0A3S0ZBI4"/>
    <dbReference type="OrthoDB" id="6151759at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053164">
        <property type="entry name" value="IS1016-like_transposase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024445">
        <property type="entry name" value="Tnp_ISXO2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163">
        <property type="entry name" value="DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163:SF2">
        <property type="entry name" value="SI:DKEY-17M8.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12762">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01126">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ISXO2-like transposase" evidence="2">
        <location>
            <begin position="195"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="397"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS71147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="496" mass="55671" checksum="48D97773615EB0B8" modified="2019-04-10" version="1">MGSRACPGRSGATDTGLPAESYQVAYRRVTAWKSVKSARVCGDVDDLLDNLEDLQAHRKVEVISTPTMEVEKPTRPTNADTHFTNHVGIEGNEMADELVKIGLGKGRSMGRGRGRGKGKTSASSASCLFLFRRKKQLDQKIKIFYTSGDIARLLPHKSIGITKPLVCLGLSKHTVVDWRSFCSEVTDEWYRKQSPIGGPGVVVEIDETLITRRKYNRGRLPTQIWPFGGIERVTKRKFIVPLTGDVAENRTKETLLPLITKYIVKGSVIYSDAFRSYHTIKDLGSVIYSDAFRSYHTLKDLGYTHCVVNHSKNFVDPEDPNVHTQNIERLWKDVKSWVKRPVIRSKYLYQYLGRYFFATSHELSTPLHHFFIQAAKLYPPQSDRSPTANAELSDSFAARSTRPSSAIPSSATSANPFPWTLASNPAGPSIPAPAPVSNPAGIRSFFLEQLKPHFSHRGRGRSARVQRFRYGESLTEDDCVRRLREEEAARTRQCKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZD47</accession>
    <name>A0A3S0ZD47_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_016051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000682">
        <property type="protein sequence ID" value="RUS76173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZD47"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS76173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="283" mass="31446" checksum="82BD6D09C75C7774" modified="2019-04-10" version="1">MVSPPCIVCGIRKIVRGVFEVRYAEKVTIYYAKDVAPGEPSPQHCHAYVVSEARGTRVGPPDQSSLLHKTDAARPGMLRMSPQRSGPCMVVESAVPEPPPFDSIILSASRARRPRRLISYLNRADLRAALRGNSDQNLFPQFFLSTWRPGGFRPRASVTVGESETNTQACCLLRLDAWNRASPAMLCFVKAGFENGLRRSWAEQIQTNQSGAASRRNTRGTECLLELPVYGYYVDSILFFISRLERWINKTDPLLLCGKPVNISQALWVNLQRLDTPGGGGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZP05</accession>
    <name>A0A3S0ZP05_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C1q domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_020347</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001144">
        <property type="protein sequence ID" value="RUS71894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZP05"/>
    <dbReference type="OrthoDB" id="6154955at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050392">
        <property type="entry name" value="Collagen/C1q_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427:SF52">
        <property type="entry name" value="C1Q DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427">
        <property type="entry name" value="EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0176">Collagen</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018523280" description="C1q domain-containing protein" evidence="4">
        <location>
            <begin position="21"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="5">
        <location>
            <begin position="19"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS71894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="160" mass="17430" checksum="01260715E41D80BD" modified="2019-04-10" version="1">MAFKLVAALLAFALPACVLGVQEIAFSAGLAHHEYLQASQKVVYDTIFVNVGGGYDSTTGVFTCPTPSLYMFQFHALSHSSSNMWLELHHNYAYVSSIWGHIDQDYAAASNSVILRLAKNDQVYIQTADQTDLYGATSEVYGTFSGYLIAAVNEDFPVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZQT2</accession>
    <name>A0A3S0ZQT2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-terminal kinase-like protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">SCY1-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_007625</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum. Involved in the maintenance of the Golgi apparatus morphology.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000200">
        <property type="protein sequence ID" value="RUS84598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZQT2"/>
    <dbReference type="STRING" id="188477.A0A3S0ZQT2"/>
    <dbReference type="OrthoDB" id="447103at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF3">
        <property type="entry name" value="N-TERMINAL KINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="18"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="5">
        <location>
            <begin position="388"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="540"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="586"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="555"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="586"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="599"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="630"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="646"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="673"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="713"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="727"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="743"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="760"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="774"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="797"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="824"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="861"/>
            <end position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00042347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00056114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS84598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="871" mass="95856" checksum="37A5650968BB8CB6" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZQT5</accession>
    <name>A0A3S0ZQT5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_011624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000382">
        <property type="protein sequence ID" value="RUS80614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZQT5"/>
    <dbReference type="OrthoDB" id="10645967at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS80614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="190" mass="20596" checksum="4CA5476402AE3AE2" modified="2019-04-10" version="1" fragment="single">MTEYDDTLIDMSDVDDKLDDETETSSSEIDERRPSTSESQAADHNSLANNCRSFPDSINSNSNPILVVSSKYYIRNARTEPQQEEEQAQESASSDSSRAALEETEKIEDSKNSASLSNSNVGPSLDSTFVNENTSPQLSSGEVSDTEEDNDDSFASPVGGELRDAENCSTAAEESLSESPEAVSDSETRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZRZ4</accession>
    <name>A0A3S0ZRZ4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MRCK/ROCK kinase PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_007828</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000206">
        <property type="protein sequence ID" value="RUS84444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZRZ4"/>
    <dbReference type="STRING" id="188477.A0A3S0ZRZ4"/>
    <dbReference type="OrthoDB" id="6263410at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072518">
        <property type="term" value="F:Rho-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901888">
        <property type="term" value="P:regulation of cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20813">
        <property type="entry name" value="C1_ROCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01242">
        <property type="entry name" value="PH_ROCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000308">
        <property type="entry name" value="Rho-associated protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057529">
        <property type="entry name" value="MRCK/ROCK_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF73">
        <property type="entry name" value="RHO-ASSOCIATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25346">
        <property type="entry name" value="PH_MRCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MRCK/ROCK kinase PH" evidence="2">
        <location>
            <begin position="2"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS84444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="143" mass="16501" checksum="9D0906D26070A87D" modified="2019-04-10" version="1" fragment="single">MEGWLAVPNRSNIKKYGWRKQYVVVSSRKVLFFNSENDKQNTDPILVLDIDKLFHVRPVTQGDVYRADAKDIPRIFQILYASEGENRKQEETTAEAAMDRTGVISYKGHDLITLTYRTPTSCDSCHKPVWHVIHPPPALECKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZV32</accession>
    <name>A0A3S0ZV32_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_016271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000696">
        <property type="protein sequence ID" value="RUS75964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZV32"/>
    <dbReference type="OrthoDB" id="17800at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022564">
        <property type="entry name" value="DUF2678"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28603">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28603:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10856">
        <property type="entry name" value="DUF2678"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS75964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="74" mass="8328" checksum="404EDE0ABD4660FC" modified="2019-04-10" version="1" fragment="single">VTLISALVFPAWPPNGVNVFFGLVIVLICASHLVLIYWYRQGDLEPRFRPMIFYNAFTVVLLCVVGNCYIHGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-05-03" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZY95</accession>
    <name>A0A3S0ZY95_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_003249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000069">
        <property type="protein sequence ID" value="RUS89002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZY95"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS89002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="100" mass="10957" checksum="D56C0517A3C607D3" modified="2019-04-10" version="1">MGMGYTMCLLIKCIVHHRAALVKLSHTTIIMVRGDHPIDRLAGGVISSFYLLFPRIKNNGEVKERQLLFIMNSGGLGCIAPNVLTGTFSGLFNCKLFMGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZYR6</accession>
    <name>A0A3S0ZYR6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_002793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000056">
        <property type="protein sequence ID" value="RUS89420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZYR6"/>
    <dbReference type="STRING" id="188477.A0A3S0ZYR6"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017064">
        <property type="term" value="F:fatty acid amide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052096">
        <property type="entry name" value="Endocannabinoid_amidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45847">
        <property type="entry name" value="FATTY ACID AMIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45847:SF6">
        <property type="entry name" value="FATTY ACID AMIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS89420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="147" mass="16200" checksum="5DB9BE12E1FF71B9" modified="2019-04-10" version="1">MKREPLSTLTDWFLKTNELMRFKNEFNETWREQGLDAVICPAMPCVANTSGVDAQLLSAVTYTSLYNVVNFPAGIVPVTKVTKSDVTKTMDPSVYIAKTGIEKIIQADSEGTEGLPVGIQVVGVPYTEELVLRVMAELEKALKTNTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A094</accession>
    <name>A0A3S1A094_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_004867</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000112">
        <property type="protein sequence ID" value="RUS87413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A094"/>
    <dbReference type="STRING" id="188477.A0A3S1A094"/>
    <dbReference type="OrthoDB" id="6273063at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="2"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="292"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS87413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="563" mass="62387" checksum="FFA787354FC79AF0" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A2D3</accession>
    <name>A0A3S1A2D3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_000104</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000002">
        <property type="protein sequence ID" value="RUS92080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A2D3"/>
    <dbReference type="OrthoDB" id="10444073at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS92080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="116" mass="12931" checksum="7AB6B602D2D49D90" modified="2019-04-10" version="1">MFRCVFKGGSKISESTSDYAVKPQRSKDFTAISWARGGEIPAARLADWRASISGMIGVRLGRCFIEPTQGRLAPCRNLNYQQISGKVPKSKRTKYRATNMFVDHLQGEPAPKRAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A2X3</accession>
    <name>A0A3S1A2X3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amine oxidase</fullName>
            <ecNumber evidence="3">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_010904</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="3">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="2">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="2 3">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="3"/>
    <dbReference type="EMBL" id="RQTK01000343">
        <property type="protein sequence ID" value="RUS81337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A2X3"/>
    <dbReference type="STRING" id="188477.A0A3S1A2X3"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF20">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="4">
        <location>
            <begin position="3"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="6"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="1">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="2">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS81337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="227" mass="26082" checksum="B9C2AFC4E2A414B9" modified="2019-04-10" version="1" fragment="single">GANYVDSGALSGLGTKALVPGADCPDSATLIPSTVWNQHGGEPGRYDAALCMFEINNAYPLRRDLKYRKRNGFYGGMLDSVLTLRAILAVGSYDYVIDFIFHQNGVMETRLMSTGFIMGNVFRAVERQYGFRIEETLTANLHHHMFHLKVDLDVSGTSNRYETLNVEPMETKLCWDKSRDYAQTKFTTHLKRTEQEALYKYDFNHPKYHIVHNDARRNQWGEKRAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A6W8</accession>
    <name>A0A3S1A6W8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_007977</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000212">
        <property type="protein sequence ID" value="RUS84225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A6W8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS84225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="144" mass="16144" checksum="614CAAA1F4E67C7C" modified="2019-04-10" version="1" fragment="single">DYLQHPEDAACVPVVVVAKGNVLHTSAVPQEPFHMLEEPRLVVVADSNTHLARFRRVHHVAQHEHGLSLRVDERLHELVVSVDLRIVEQTAQFAVADHWLVLHPHVLAGRHDAQLCGHQEAQGAVRPGDGVEQVWVLILRSKHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A7X6</accession>
    <name>A0A3S1A7X6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_007400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000191">
        <property type="protein sequence ID" value="RUS84859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A7X6"/>
    <dbReference type="STRING" id="188477.A0A3S1A7X6"/>
    <dbReference type="OrthoDB" id="6135320at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22750">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="8">
        <location>
            <begin position="65"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS84859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="358" mass="39872" checksum="ECB6AF2E7EC72E23" modified="2019-04-10" version="1">MNCTLRSFNASTTTTPTTSNSSAGGDPALQQALPELCDFNTSCRFRSHWGWLVLMISLASVTCSANLLSLVVLRRMHATMSPVMRLALMNLSLTDVVGSLSYIYHSVMSFTTLEVVGVECKIRYLFYVGMNVVTLYTLIYMTVERLVAVTLPFLHVRVDGKKFTAVALTLIWVASMATLVSGMHRLRTDLDLCLYHVMVPKTTHLLNASLALPTIVFIVLSNLALYVRARREITKIGRTMVSSAEDNQRERQLAHMAEKAASTTLAVVVPFASFNTPLYVLMLVFYCRPEFMYSCRSVGLLMSFSTLLVLNSLCNPIIYAWKLRPVQVELAKMLRMRCLARKSGPAPTVVSTVVTRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A9U1</accession>
    <name>A0A3S1A9U1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_005905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000142">
        <property type="protein sequence ID" value="RUS86320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A9U1"/>
    <dbReference type="STRING" id="188477.A0A3S1A9U1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS86320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="111" mass="12037" checksum="19AB6B8FC6E9A9F4" modified="2019-04-10" version="1" fragment="single">HALLPPLHVLSPLHVLSPLHVLSPLHVLSPLHVLSPLHVLSPLHVLSPLHVLSPLHVLSPLHVLSPLHVLSPLHVLSPLHVLSPLHVLSPLHVLSPLHVLSPLHVLLSQLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1ADB8</accession>
    <name>A0A3S1ADB8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Syntaxin-8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EGW08_003243</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">EC2010</strain>
            <tissue evidence="15">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000069">
        <property type="protein sequence ID" value="RUS88996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1ADB8"/>
    <dbReference type="STRING" id="188477.A0A3S1ADB8"/>
    <dbReference type="OrthoDB" id="428895at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15852">
        <property type="entry name" value="SNARE_Syntaxin8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000036">
        <property type="entry name" value="Putative Syntaxin-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041875">
        <property type="entry name" value="Syntaxin-8_SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF124">
        <property type="entry name" value="SYNTAXIN-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="14">
        <location>
            <begin position="148"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RUS88996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="242" mass="27447" checksum="09D4F10945351AB5" modified="2019-04-10" version="1">MAGDSWLSDYDFCSNLGQDIMEKINERDKHARTSSAYTKLSAQIRTKSKQFNSDLNRLKQNLMRASSSYHVTQREVERRQRMMDALVTKEKQIEGALKNEGQSRAPTDRTMLLAGAGSSGAETFSSSDPWGMGDDPDISNADLHQQQQHVIIEQDRGLEALSTVISRQKQMALDIGNEVDDQNELLDDLNERVDRTDNRIQRETRHIKIIDRKSNACCYYVVIILLFVAILIVALVPYNGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1ADS8</accession>
    <name>A0A3S1ADS8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Laminin EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EGW08_002910</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">EC2010</strain>
            <tissue evidence="16">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000059">
        <property type="protein sequence ID" value="RUS89303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1ADS8"/>
    <dbReference type="STRING" id="188477.A0A3S1ADS8"/>
    <dbReference type="OrthoDB" id="5985440at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="6"/>
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        <property type="entry name" value="Laminin subunit beta 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Laminin subunit beta 4"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Laminin subunit gamma 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Laminin"/>
        <property type="match status" value="7"/>
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        <property type="entry name" value="EGF"/>
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        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050440">
        <property type="entry name" value="Laminin/Netrin_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000034">
        <property type="entry name" value="Laminin_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
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    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574:SF444">
        <property type="entry name" value="BASEMENT MEMBRANE-SPECIFIC HEPARAN SULFATE PROTEOGLYCAN CORE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574">
        <property type="entry name" value="NETRIN/LAMININ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00052">
        <property type="entry name" value="Laminin_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00281">
        <property type="entry name" value="LamB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51115">
        <property type="entry name" value="LAMININ_IVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 12" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Laminin EGF-like" evidence="14">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin IV type A" evidence="15">
        <location>
            <begin position="71"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="14">
        <location>
            <begin position="323"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="14">
        <location>
            <begin position="458"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="14">
        <location>
            <begin position="505"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="14">
        <location>
            <begin position="554"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="713"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="3"/>
            <end position="20"/>
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    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="22"/>
            <end position="31"/>
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    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="477"/>
            <end position="486"/>
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    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="505"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="507"/>
            <end position="524"/>
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    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="554"/>
            <end position="566"/>
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    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="556"/>
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    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="575"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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            <dbReference type="ARBA" id="ARBA00022530"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RUS89303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1256" mass="132660" checksum="9B08B9D277FC6F10" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AUU5</accession>
    <name>A0A3S1AUU5_ELYCH</name>
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        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EGW08_023349</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">EC2010</strain>
            <tissue evidence="15">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001944">
        <property type="protein sequence ID" value="RUS68889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="7 9 11" id="KW-0371">Homeobox</keyword>
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    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="13">
        <location>
            <begin position="1586"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="13">
        <location>
            <begin position="1649"/>
            <end position="1712"/>
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    </feature>
    <feature type="domain" description="Homeobox" evidence="14">
        <location>
            <begin position="1722"/>
            <end position="1782"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="1724"/>
            <end position="1783"/>
        </location>
    </feature>
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            <begin position="31"/>
            <end position="163"/>
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            <begin position="225"/>
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            <begin position="281"/>
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            <begin position="400"/>
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            <begin position="593"/>
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            <begin position="772"/>
            <end position="796"/>
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            <begin position="810"/>
            <end position="891"/>
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            <begin position="925"/>
            <end position="1061"/>
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        <location>
            <begin position="2101"/>
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            <begin position="35"/>
            <end position="47"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="48"/>
            <end position="59"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="12">
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            <begin position="305"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="12">
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            <begin position="349"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="404"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="593"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="685"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="774"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="825"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="945"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="967"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1022"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1128"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1174"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1290"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1475"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="1499"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1529"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1545"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1778"/>
            <end position="1802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="1854"/>
            <end position="1865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1886"/>
            <end position="1917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="2122"/>
            <end position="2145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RUS68889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="2166" mass="231776" checksum="D3A002A8DDB51595" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AWG3</accession>
    <name>A0A3S1AWG3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_023135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001833">
        <property type="protein sequence ID" value="RUS69103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AWG3"/>
    <dbReference type="OrthoDB" id="10580973at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS69103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="382" mass="42327" checksum="28DF565F3AA70BFF" modified="2019-04-10" version="1">MDDTDSDEDTPRAEEATGPESRPPASRHSPLRKDCSDLAKNRENVAEKTRRISAHVKDAKERFRLAMKSEGERKMMSIGDEGKVVDHVTSKLPAQTQIKIFRGNLKSQREKGHITLTDIPPLDLIYDNEHPDSAREATTPTNVKDSVKLDLNPEHPGLSRRKTATKTILPETSDNNKSPPLTPRCTPRRNKNRDFSHIPTPRRSGDKLPTLTLSAKEDLIKEIAPGLLLRSKDSELTSSRSSVASSTSSLRSSVTSIISLTELKTLRVNCRVSEDAIVSTATNTNNTTTTNNNNSSSNNGVTSVITSNMSVTDMKRVLLGRSKVRGVEPANFCVIAVKTVKANITESPIPETEDEMVRVETEILPDDAHPFEERGRHLRRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AX10</accession>
    <name>A0A3S1AX10_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aminoacyl-transfer RNA synthetases class-II family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_021736</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001394">
        <property type="protein sequence ID" value="RUS70496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AX10"/>
    <dbReference type="STRING" id="188477.A0A3S1AX10"/>
    <dbReference type="OrthoDB" id="439710at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00777">
        <property type="entry name" value="AspRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="entry name" value="GAD-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047090">
        <property type="entry name" value="AspRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00459">
        <property type="entry name" value="aspS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001750">
        <property type="entry name" value="PRK00476.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="GAD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="7">
        <location>
            <begin position="65"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS70496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="517" mass="57701" checksum="DFBEEC8098DF5DD9" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AZ76</accession>
    <name>A0A3S1AZ76_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Condensin complex subunit 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_016306</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000700">
        <property type="protein sequence ID" value="RUS75918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AZ76"/>
    <dbReference type="STRING" id="188477.A0A3S1AZ76"/>
    <dbReference type="OrthoDB" id="1884734at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055406">
        <property type="entry name" value="HEAT_Maestro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055408">
        <property type="entry name" value="HEAT_MROH2B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048465">
        <property type="entry name" value="Maestro-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045206">
        <property type="entry name" value="Maestro_heat-like_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23120:SF0">
        <property type="entry name" value="MAESTRO HEAT-LIKE REPEAT FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23120">
        <property type="entry name" value="MAESTRO-RELATED HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21047">
        <property type="entry name" value="HEAT_Maestro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23210">
        <property type="entry name" value="HEAT_Maestro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23227">
        <property type="entry name" value="HEAT_MROH2B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="MROH2B-like HEAT-repeats" evidence="5">
        <location>
            <begin position="59"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Maestro-like HEAT-repeats" evidence="4">
        <location>
            <begin position="402"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="Maestro/Maestro-like HEAT-repeats" evidence="6">
        <location>
            <begin position="841"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="1088"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="705"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="705"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS75918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1117" mass="125636" checksum="4E85797079FA78F5" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B040</accession>
    <name>A0A3S1B040_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_023659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01002287">
        <property type="protein sequence ID" value="RUS68579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B040"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051959">
        <property type="entry name" value="PAK1-Kinase_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675:SF1">
        <property type="entry name" value="P21-ACTIVATED PROTEIN KINASE-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675">
        <property type="entry name" value="PAK1 INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS68579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="231" mass="25740" checksum="F57B1EC6C1404E02" modified="2019-04-10" version="1" fragment="single">DTKTVKEIPFQWRINAVCHVKENIFAVGGDDRLVLLVDVLTGQTVFSVDAAKSSEDKFNSRVRCLNAVDFNSKKYLVLATASGDIKVSSLDFNKESAMDLFFDQTKVRITSMGVYDSSKSMEADAPKQKKKVQDTREQIQETLDSESNNADEEDDNDDDESSEDSESKIGGSKPKKRKVEMDLASSKSARKKKKNDQETSGTKVLKSKTKKDGVLPSQKSKKKVKAKRISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B075</accession>
    <name>A0A3S1B075_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Testis-expressed sequence 264 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_019318</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001000">
        <property type="protein sequence ID" value="RUS72922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B075"/>
    <dbReference type="STRING" id="188477.A0A3S1B075"/>
    <dbReference type="OrthoDB" id="2140079at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106300">
        <property type="term" value="P:protein-DNA covalent cross-linking repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="entry name" value="Regulatory factor, effector binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15949">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15949:SF3">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="Probable bacterial effector-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS72922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="34535" checksum="F47B4748B9CAC039" modified="2019-04-10" version="1">MVEFTTFSLLLILITVLVILLLATIITVLIYSGLLQGIEDVGTGKPPVEQLIIAYKFQQGPYHEAGQIFTEAAIIAPENKAIGIYYDDPKKVSPLFLRYAVGSIIAEGKAAVDENMVKQFTERGFKILHLPEVSYAVQTRFPHVTTLSILIGIRKAYPRLEEYIEEHKLCAHPCMEYYDGKYIHFFAPLSKQDEFYVPECTREGASGDADRTQSDAGSFSGSEALHDTEASLNVTQDSVETNTTLDQNESMLESQRDPRIDDDGKVEEVDLKGSETASEKENKGNEKDDDDDVSDDSSSSFEVVKKEKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B414</accession>
    <name>A0A3S1B414_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Uridylate-specific endoribonuclease</fullName>
            <ecNumber evidence="11">4.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_020792</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ribonucleotidyl-uridine-RNA = a 5'-end dephospho-uridine-RNA + a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA</text>
            <dbReference type="Rhea" id="RHEA:67792"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:17354"/>
            <dbReference type="Rhea" id="RHEA-COMP:17356"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:173117"/>
            <dbReference type="ChEBI" id="CHEBI:173224"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ENDOU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.-" evidence="11"/>
    <dbReference type="EMBL" id="RQTK01001210">
        <property type="protein sequence ID" value="RUS71442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B414"/>
    <dbReference type="OrthoDB" id="430326at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21159">
        <property type="entry name" value="XendoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039787">
        <property type="entry name" value="ENDOU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037227">
        <property type="entry name" value="EndoU-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018998">
        <property type="entry name" value="EndoU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12439:SF42">
        <property type="entry name" value="ENDORIBONUCLEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12439">
        <property type="entry name" value="PLACENTAL PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09412">
        <property type="entry name" value="XendoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142877">
        <property type="entry name" value="EndoU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51959">
        <property type="entry name" value="ENDOU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="EndoU" evidence="12">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS71442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="177" mass="20179" checksum="CF754EF4B2F20E53" modified="2019-04-10" version="1" fragment="single">MFTFVNETKLTSSSVYRTYLALLNNYDPDKYDAELVTASEAAEENAFLDAILSTATMKTLYNYLSKVGSMSDMRSMLRRLWFDLYRRSPSASNLDTSGFEHVMVGEYKSSSLVNGLHYWLAFYWLEKGGQVNYYGHSCTSRPTSMCAAYEWNGRTKSNSSFFLRSSPAFDLAVYTLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B6R6</accession>
    <name>A0A3S1B6R6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_011119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000354">
        <property type="protein sequence ID" value="RUS81133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B6R6"/>
    <dbReference type="STRING" id="188477.A0A3S1B6R6"/>
    <dbReference type="OrthoDB" id="4760524at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS81133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="120" mass="13227" checksum="209EDA2FE78C4695" modified="2019-04-10" version="1" fragment="single">NSGNYMGFAPETCSQYTAPTSRSQYTAPTSRSQYTAPTSRSQYTAPTSRSQYTAPTSRSQYTAPTSRSQYTAPTSRSQYTAPTSRSQYTAPTSRSQYTAPTSRSQYTDPTSRSQYTDPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B6X6</accession>
    <name>A0A3S1B6X6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Neurotransmitter-gated ion-channel ligand-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_014754</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000577">
        <property type="protein sequence ID" value="RUS77479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B6X6"/>
    <dbReference type="STRING" id="188477.A0A3S1B6X6"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000060">
        <property type="entry name" value="Nicotinic acetylcholine receptor subunit alpha4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="7">
        <location>
            <begin position="9"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="8">
        <location>
            <begin position="125"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS77479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="30744" checksum="FF35BFBA8F9E7AE7" modified="2019-04-10" version="1" fragment="single">ADLRLKEHRDALCIINSTGFVYHVPQVVYKSSCPIDVYVFPFDIQNCTLKFGSWAYTGNELDLQFYDNKQWIDLTEYLESSSWTIVDCPAYRHVTMYSCCPDSPWVDMQYHLIFQRRSTLYNYILILPCILLTSITLILFFIPPESPAKMQLGLAVFIAFFVLLRLLEKNLPPGTSHMPLLGTYYCLNMILITLSSFLNVLIVDLTTHGLRTSAPPRFRKFFFNYLARCLLMEDLVRPFKSAPPKSRGQQDGNLGKLEENKWKHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B7D7</accession>
    <name>A0A3S1B7D7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_018362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000891">
        <property type="protein sequence ID" value="RUS73876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B7D7"/>
    <dbReference type="OrthoDB" id="6110357at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS73876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="370" mass="42207" checksum="7E55E91CD77A5AF5" modified="2019-04-10" version="1">MGTCCSTKPHEPSPTAPPNLGQHHSLFVHPSNREGISNSYNIVYRPPHLNQRLVPGESRPRFWLSPTLPSPPGQPIVSLAWTQPDPQESEQQQQLQQLQQKQQQQQEEQQRDRQGLGKLGIRLKSPTRAIRWSKNIRCSPHNPSLHGPSEQDSKAEGSVIRCDGHRLTIRAYPRFLMPYIDKVLRLRLVFTDPLVEQMVGEYSHLRHGSQEDDVDPMMEISHLVRNVHSLKVQFKHSENMTGLPDMTVVESHGGVKRLRRVRYRTMPVTWIDLDHRKPMVKAVGEQFELTLGPPSATLTSDDFYDGNGETPTLLGTYERCLDTAPERRLTFSVRFYHWFNQAMPAECCSDLSDICEQSTPQFGALRLGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B8T7</accession>
    <name>A0A3S1B8T7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_009713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000282">
        <property type="protein sequence ID" value="RUS82541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B8T7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS82541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="202" mass="22819" checksum="E099A91C290B354D" modified="2019-04-10" version="1">MMELIRDGCIGEDDDYGGGVGCRGVGGGGGGNGDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDTTDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDNDDDDDDDDDDDDDDDDDDHNNEDEDEQEYWQNRMKRISILRYDSDDDNDNGDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDVDDDGYVAREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BBX2</accession>
    <name>A0A3S1BBX2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_011807</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000391">
        <property type="protein sequence ID" value="RUS80438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BBX2"/>
    <dbReference type="STRING" id="188477.A0A3S1BBX2"/>
    <dbReference type="OrthoDB" id="263283at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056737">
        <property type="entry name" value="Beta-prop_ATRN-MKLN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051568">
        <property type="entry name" value="LZTR1/Attractin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376:SF2">
        <property type="entry name" value="DISTRACTED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24981">
        <property type="entry name" value="Beta-prop_ATRN-LZTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23106">
        <property type="entry name" value="EGF_Teneurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018764499" description="CUB domain-containing protein" evidence="6">
        <location>
            <begin position="28"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="7">
        <location>
            <begin position="32"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="171"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS80438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="559" mass="62204" checksum="3BB1ADF202CD0DB9" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BDM8</accession>
    <name>A0A3S1BDM8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_010668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000330">
        <property type="protein sequence ID" value="RUS81567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BDM8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS81567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="298" mass="32952" checksum="90F536B5FD0A1BD6" modified="2019-04-10" version="1">MQQLLPLRHTILLMWGGDVISDDETVWVDVGVVVEGEVGDEIGRGAEAYRLHHSTEHRWNLVTLSPGRGRVNKDVTKAGQAEQTAGKGRDLGQGTQADDTRTADAIVVSIATTSSGKAYNDTQPRIQYRDIYDGDNDDDDDNDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDNNTNNNNNNNNNNNNNNNNNNNNGDDDDDDDDDDDDDDAAAADDDDDDDDDDGDDGDDDDDDDDDDNDDDDDYYDDDDVDDGGGGDCDYDDDDDDGLDNYSDKDESEILTEGNFSATIQIRCKFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BJV2</accession>
    <name>A0A3S1BJV2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_002248</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000043">
        <property type="protein sequence ID" value="RUS89981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BJV2"/>
    <dbReference type="STRING" id="188477.A0A3S1BJV2"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000115">
        <property type="entry name" value="Lysosomal aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018548178" description="Peptidase A1 domain-containing protein" evidence="8">
        <location>
            <begin position="25"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="9">
        <location>
            <begin position="70"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="101"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS89981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="337" mass="36758" checksum="215E02E56F970602" modified="2019-04-10" version="1" fragment="single">MYNSIKMKTQTVLTLAVLIASCLALDPMHIPIYSMIKPEQKLDSLIRQVKFYQESNSDDEPLKNFQDAQYYGPITVGTPGQPFNVIFDTGSSNLWIPSVHCPRSDVACQKHNKYNNATSKTYRPNGKPFVIQYGTGNVEGYLSTDTITVAGVSVVNQTFGEAVKESQDFVGTPADGLLGMGFPEISEDQVPTVFGNMVRQKLIPEPVFSFYLNRDEKASPGGVLTLGGTDPDHYTGDFTFVDVTKKGYWQFDMDRVNVKGEELTLCKSGCSAIADTGTTLIVGPSSEVNALNSQLGGAPTSQGLYIVDCKKVNSLPDVVFTLNGQQLTLTGPQYTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BLQ9</accession>
    <name>A0A3S1BLQ9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_022188</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001504">
        <property type="protein sequence ID" value="RUS70049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BLQ9"/>
    <dbReference type="STRING" id="188477.A0A3S1BLQ9"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140358">
        <property type="term" value="F:P-type transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015203">
        <property type="term" value="F:polyamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF8">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="317"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="342"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="379"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS70049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="390" mass="43867" checksum="547DC14A22943A89" modified="2019-04-10" version="1" fragment="single">LLLFVLCREGRAAITTAFGVFKYIACYSLTQFASVLILYWVGANLTDAEFLYIDFFLITTFSITFSRTGPYQELVRERPLVSLLGASPILSILIQMILVIAVQTFMYLNVQKQPWFVSFQDNDEDDYMSYENSAVFFASSYQYIILAITFAKGAPFRSSIFSNYWLLANIVIALGGTIWINMYPTDGLAELLEIKEFPSMTYKALYIGVAFINFLLSFIMEKFLIDNEVLREKLRAHLKECLPMQDQAYAKIESEIEKNPTWPPVSDKKVDLATIFQKQESVVSVENNMEKSNITLEDLLEHSDHEDHGLALLSEKDNDDSELQPSYEAASQPTSSAAVTFSLLSSQKSQSTSSLTTSSSPPSSSTQQDSQKTDEKSQDISSPTETVTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BMC0</accession>
    <name>A0A3S1BMC0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_005143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000120">
        <property type="protein sequence ID" value="RUS87067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BMC0"/>
    <dbReference type="OrthoDB" id="10632440at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS87067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="540" mass="59424" checksum="65C3D8252BC44686" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BQ67</accession>
    <name>A0A3S1BQ67_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_003450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000073">
        <property type="protein sequence ID" value="RUS88820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BQ67"/>
    <dbReference type="STRING" id="188477.A0A3S1BQ67"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS88820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="190" mass="23590" checksum="C9F000DC0BACE93E" modified="2019-04-10" version="1" fragment="single">TVTSDRFSLRLSCRFSFWFSCRFSFWFSCRFAFRFSCRFSCRFPFWFSCRFSCGFAFWFSCRFSFWFSCRFAFWFSCRFSFRFSCRFAFRFSCRFSCRLSCSHSFWLSCRFAFWFSCGFPFWLSCRFSCRFAFRFSCGFAFRLSCRFSLRFSCRFPFWFSCRFSRRFSCGFSCWLSCRFAFRLSCGFSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BR41</accession>
    <name>A0A3S1BR41_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_002802</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the vasculin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000056">
        <property type="protein sequence ID" value="RUS89429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BR41"/>
    <dbReference type="STRING" id="188477.A0A3S1BR41"/>
    <dbReference type="OrthoDB" id="8741226at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028128">
        <property type="entry name" value="Vasculin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14339">
        <property type="entry name" value="VASCULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14339:SF12">
        <property type="entry name" value="VASCULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15337">
        <property type="entry name" value="Vasculin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="298"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
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            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="251"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="298"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS89429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="475" mass="53805" checksum="C94DE951DEF96219" modified="2019-04-10" version="1">MADSNLPKQDFAPPWLKFPQADSAKSQGQKLSGYQGDRNRQRREDPYHSRSDYNRLHRQTSFDYHESKRFPSGQGKYRHHSVDDDYYGYSYGYGYYSPDYNYEKYGMHYSSQPSLARRDGKYGPGRFPPGGADFSPPYELYEPSYHPNMSRRGYYDNHMNGRDYDMKSRERGHPRDKNFSDDFPSLVAKGEQDVKRSKPAAGAWENPPKSSRVDESSDNKSASSGIYKALVPSKNGQVKRNGRVNGTGRDSSPLSPSSKLNNPKESAHQNSATDLAIVTQPKKLGDKKSQFLKALRNESSVRNGENGQDHNQNAVEKKQVDRDEDSSSPENYETNSMVAGIEEKKILKGENVHKITSTLNGDVNSTDKSNLESEKKVNGEALVDDVEQICLSGEEEEKRLLLSMGWVEEDNTEYVITEDEIREFQSKLQNHCHGQRNGLKTTLRNALNLKLDNDLTNGVVNGSCIKEDNDRNKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BR82</accession>
    <name>A0A3S1BR82_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_005496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000130">
        <property type="protein sequence ID" value="RUS86706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BR82"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS86706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="150" mass="18178" checksum="425F905B3D8ABE29" modified="2019-04-10" version="1" fragment="single">YVYKMESISPDFTVYLELYTYGYVYKMESISPDFTVYLELYTYGYVYKMESISPDFTVYLELYTYGYVYKMESISPDFTVYLELYTYGYVYKMESISPDFTVYLELYTYGYVYKMESISPDFTVYLELYTYGYVYKMESISPDFPVYLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BRA5</accession>
    <name>A0A3S1BRA5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_019220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000985">
        <property type="protein sequence ID" value="RUS73014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BRA5"/>
    <dbReference type="STRING" id="188477.A0A3S1BRA5"/>
    <dbReference type="OrthoDB" id="432381at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052775">
        <property type="entry name" value="IUN_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048325">
        <property type="entry name" value="ZSWIM3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46190:SF1">
        <property type="entry name" value="SI:CH211-201H21.5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46190">
        <property type="entry name" value="SI:CH211-201H21.5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21599">
        <property type="entry name" value="ZSWIM3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZSWIM3 N-terminal" evidence="4">
        <location>
            <begin position="5"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="3">
        <location>
            <begin position="194"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS73014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="389" mass="43416" checksum="8DCF78B5B6E85BE2" modified="2019-04-10" version="1" fragment="single">MSIINVDDEFSSYEEVEERIQQLQDTEKFKLWKRDSRTIAAAIKRMPKRVFNPEVKYNELLYCCVYGGRETKDELRSMRQRCPYQIKFRCTQDGQRLRVVSITPNHNHGPAEATEADVGESKTAVSPSPPASDADADEEEEAFTSNSSDVNIEDMMDSPDTNNLAMSNTSDGLSGLQPVKLVSNMSFKQPKLKVILDVDTGIDDSHAIMLALAHHNVEILAITCANGNVNVDLVVENTLRVLHACGREDIPIYRGAECSLLGNTSQFENFSGEAWNTPVDTSVVQKEHAANAIIRIISNYPGEVTVVALAPLTNLALAMRLDSTVGRKIKDLYIMGGNIEGRGRISPCAEFNFYNDPEAAQVVLKEFINITILPYEVCRKFLLPWDFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BSS6</accession>
    <name>A0A3S1BSS6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_001499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000026">
        <property type="protein sequence ID" value="RUS90695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BSS6"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018548179" evidence="1">
        <location>
            <begin position="20"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS90695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="146" mass="15941" checksum="0855435530146661" modified="2019-04-10" version="1">MKAAFLVCLTVAVLVSCSAQSYDTPLCLSGEELCGGKRSIHDSQGVKRCCPDGRRIYNQSPTRLHQSSTPGCISPQLQVVSVLNSRLHHFSTPGCTSPLTCQPSHHEGRFSCLLDCRCPGLLLSAELRHPPLSVWRGTVWGQTFHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BTR0</accession>
    <name>A0A3S1BTR0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_001135</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000018">
        <property type="protein sequence ID" value="RUS91110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BTR0"/>
    <dbReference type="STRING" id="188477.A0A3S1BTR0"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF176">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018377843" description="Transmembrane 9 superfamily member" evidence="7">
        <location>
            <begin position="19"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="471"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="525"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="554"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="594"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="625"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS91110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="664" mass="75887" checksum="57638D31FC6746A0" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BVD2</accession>
    <name>A0A3S1BVD2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_016498</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000715">
        <property type="protein sequence ID" value="RUS75747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BVD2"/>
    <dbReference type="STRING" id="188477.A0A3S1BVD2"/>
    <dbReference type="OrthoDB" id="19711at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF1">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="5"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="127"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="167"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="207"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="247"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="287"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="327"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="366"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS75747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="440" mass="49864" checksum="649DA850FD48DEE4" modified="2019-04-10" version="1">MTRGFDFTQFLPVELTDTILETFDARDLSKFQCVCVNWREFGNSDEFWFRFCAQEHYIHYGPTDDILREKSFSRRTTNVSSNSPVFDLKVPENTRLSPICKWKHIFLRRNHLNKNWRKGRYTVAPALRGHTDKVTAFDCDGNVIISGSDDKTVRVWDLNTCQCIRRISGHSDTVSSIKIVGKQVITGCGDSMIRVIDIATGKLVLTFMGHGGSVDHLCVSASKLVSAGTDRTVRVWCLESKELKQILRIHTDEIECLSTHGNFAVSGSWDNTLVLWNLKTGECVHHCIGHNEVVNCCQFDSKRIVSGSADGDARIWSCLTGLCLHVLSGHQAEIYCLVYNEVIIATGSSDSTVRMWTHEGKLLRTLEEHMGVVRCLHINEDRLVSAGDQRMIVVWDYKKGKKMSVLHRHPSKLHLMWISNTKLITASPEKVGTLTVMSFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BVT7</accession>
    <name>A0A3S1BVT7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_016126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000687">
        <property type="protein sequence ID" value="RUS76095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BVT7"/>
    <dbReference type="OrthoDB" id="6162398at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052293">
        <property type="entry name" value="SRRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12239:SF41">
        <property type="entry name" value="MEMBRANE ASSOCIATED PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12239">
        <property type="entry name" value="PROTEIN CBG20215-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS76095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="101" mass="11876" checksum="755D5FBFDC147FB7" modified="2019-04-10" version="1" fragment="single">TRTPEHQNTRTPEHQNTRTPGAIGTPEHQNTRNTRTPEHQNTSTPEHQNTRTPEHQNTRTPEHQNTRTPEHQNTRTPEHQNTRTPEHQNTRTPEHQNTRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BWJ6</accession>
    <name>A0A3S1BWJ6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">EGW08_001744</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">EC2010</strain>
            <tissue evidence="19">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000031">
        <property type="protein sequence ID" value="RUS90476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BWJ6"/>
    <dbReference type="STRING" id="188477.A0A3S1BWJ6"/>
    <dbReference type="OrthoDB" id="9998912at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056737">
        <property type="entry name" value="Beta-prop_ATRN-MKLN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056732">
        <property type="entry name" value="GBD_ATRN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051568">
        <property type="entry name" value="LZTR1/Attractin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376:SF2">
        <property type="entry name" value="DISTRACTED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24981">
        <property type="entry name" value="Beta-prop_ATRN-LZTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24972">
        <property type="entry name" value="GBD_ATRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 13" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="11 14" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1029"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="16">
        <location>
            <begin position="84"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="198"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="18">
        <location>
            <begin position="817"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="835"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="847"/>
            <end position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RUS90476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1192" mass="134566" checksum="6E4613437257A58B" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C5G7</accession>
    <name>A0A3S1C5G7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Carbohydrate sulfotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_008744</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the galactose-3-O-sulfotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000241">
        <property type="protein sequence ID" value="RUS83494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C5G7"/>
    <dbReference type="OrthoDB" id="514299at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001733">
        <property type="term" value="F:galactosylceramide sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009729">
        <property type="entry name" value="Gal-3-0_sulfotransfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14647">
        <property type="entry name" value="GALACTOSE-3-O-SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14647:SF87">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06990">
        <property type="entry name" value="Gal-3-0_sulfotr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS83494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="25814" checksum="E6E0CAB43D2213C5" modified="2019-04-10" version="1" fragment="single">ETRQVVFAKVHKAASSTVQNILLRFAMARNLSVLLPRNGPVLSQTSSKIERSRIVPHIQGKQLYDILCSHVLYEAKEIDKYFPKNAFRVAIFREPIKQVLSALMYHTSCGHRYLTDRYRRHKLDPINAFFKHSKDFNNGIKCPNPETFLINRMSYDLGINISEIDESKANRTTIDTFVKDTEHTFNLVLISDFFDESMVLLGRTLKWSMKDIIYIKVNAMHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C9W9</accession>
    <name>A0A3S1C9W9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">X-box-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_005323</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000124">
        <property type="protein sequence ID" value="RUS86918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C9W9"/>
    <dbReference type="STRING" id="188477.A0A3S1C9W9"/>
    <dbReference type="OrthoDB" id="6606299at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14706">
        <property type="entry name" value="bZIP_CREBZF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052470">
        <property type="entry name" value="ER_Stress-Reg_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46542">
        <property type="entry name" value="X-BOX BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46542:SF1">
        <property type="entry name" value="X-BOX BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="270"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="290"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS86918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="433" mass="47253" checksum="1E1E9BADBEBF6DA5" modified="2019-04-10" version="1">MAQYEFEGVSFDDLWDKDDAVVSSDSVMDVMKDPFVAPQSHNIGLFYPGAELSSADVTRGSKAADMNLNALPSGLISENFDLVKLDKSPWHESDSGISMIMSEAGSPTGCDDLTVDTVASIQPVVDWSGLDEGTDDLATYLLGADISILDNDKEGALVHNFEQSQGSPTNINNISTKNICYPRALSSGAPQHLPMDSDLNIDVENSDSECSSSGGISLERHNFQNADPLNYFQEVCTKTKRKPAVKVLKVLKASPASDCCDDDIMKALDERSRKNAIQAKMNREKKKVYVNGLEKDVEKLGKENKELRDENIELKKNLGSLEEEVRYLKSVLVNASSLSSLLRNIGGVSEVKLSASIVGRKRGASEFVDHSYTADANTRSDNSRAERSAKRARMVHENLERAGVCLHVNGSEASLEFCSKCSSLAKHTQSQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1CA53</accession>
    <name>A0A3S1CA53_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase M12B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_005083</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000118">
        <property type="protein sequence ID" value="RUS87151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1CA53"/>
    <dbReference type="OrthoDB" id="6147457at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF159">
        <property type="entry name" value="ADAM METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13688">
        <property type="entry name" value="Reprolysin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12B" evidence="3">
        <location>
            <begin position="138"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="353"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="353"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS87151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="535" mass="60406" checksum="7C393ECAB32B477B" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1CDB0</accession>
    <name>A0A3S1CDB0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_002617</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000051">
        <property type="protein sequence ID" value="RUS89599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1CDB0"/>
    <dbReference type="STRING" id="188477.A0A3S1CDB0"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01870">
        <property type="entry name" value="RhoA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000095">
        <property type="entry name" value="Rho-related GTP-binding protein RhoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS89599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="258" mass="28787" checksum="C77684FCBFD46A03" modified="2019-04-10" version="1" fragment="single">MAAIRKKLVVVGDGACGKTCLFIVFSSDTFPEDYVPTVFENYVADITVDGKPVELALWDTAGQEDYDRLRPLSYPDTDAILMCFSVDNPDSLHNISEKWTPEVKHFCPSVPIVLVGNKKDLRNDPSTLVELAKLKQTTVKPEEGRAMAERIGAADYVECSALLRDGVREVFETATRHALTTKRKRRGGLGLCRCCWFCIWYGLVIADPPQVKHFCPSVPIVLVGNKKDLRNDPSTLEELAKLKQTTVKPEEGRAMAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1CDF0</accession>
    <name>A0A3S1CDF0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_002598</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000050">
        <property type="protein sequence ID" value="RUS89677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1CDF0"/>
    <dbReference type="OrthoDB" id="6155902at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS89677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="171" mass="19346" checksum="A5A545120204E02F" modified="2019-04-10" version="1">MQSDPNKLYNVTIMSSDEDFPAPETNDKYGMSYLDYRGIFWLTVGSLLIPIYIIACILSVIKAHTDRKLIKARNIARQMQQPPSPAPLSPLDIIATEVRKNRWHKRESSLTLSKIRSVLKVARRQPSGTQTSPTSNIFTDRNKNTSNSKCLAAKKDSDPRDDNDDILRGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1CEM8</accession>
    <name>A0A3S1CEM8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">2Fe-2S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_001661</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the xanthine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000029">
        <property type="protein sequence ID" value="RUS90573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1CEM8"/>
    <dbReference type="STRING" id="188477.A0A3S1CEM8"/>
    <dbReference type="OrthoDB" id="8300278at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000012">
        <property type="entry name" value="Xanthine dehydrogenase/oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.120">
        <property type="entry name" value="[2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444:SF3">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="CO dehydrogenase ISP C-domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="11">
        <location>
            <begin position="25"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="[2Fe-2S]-binding" evidence="12">
        <location>
            <begin position="96"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS90573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="19812" checksum="3B2E32AFE2DBCB60" modified="2019-04-10" version="1">MSSSVVHRSISRGGIQFYLNGERHEVSDKFPPTTTLNDYIREVAGLPGTKVMCKEAGCGCCAVTVTHALDDQAPETMSINSCVCPLYSVDGWSVTTTEGLGSQRSGLHPIQQAIVDHNGSQCGYCTPGLVMAMYGLLHQNPSPTMKDIEGSLDGHLCRCTGYRAILDAAKSFGVDSPKAASIDIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1CG45</accession>
    <name>A0A3S1CG45_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_000561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000007">
        <property type="protein sequence ID" value="RUS91735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S1CG45"/>
    <dbReference type="OrthoDB" id="252722at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="679"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="810"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1028"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1091"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1210"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1343"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1398"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1482"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1541"/>
            <end position="1596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1621"/>
            <end position="1708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="395"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="713"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="763"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="815"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="835"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="878"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="929"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="954"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1031"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1091"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1219"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1400"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1413"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1441"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1551"/>
            <end position="1562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1573"/>
            <end position="1584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1685"/>
            <end position="1694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1695"/>
            <end position="1708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS91735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1708" mass="181794" checksum="0BDEC414F09B736C" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H0F3</accession>
    <name>A0A3S1H0F3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_022485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001585">
        <property type="protein sequence ID" value="RUS69755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H0F3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS69755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="202" mass="22917" checksum="3959581230724299" modified="2019-04-10" version="1">MEKDRRTGDDEDDDDDDDDDDDDDDDDDDDDDDDDDDDKECFIGATFLSCFKSQSPHRDCSPKRLTQHLVAELYLYLYYVEAARLFVSLVNGFVSGALVTEEVTEEVTEEVTEEVTEEVTEEVIVEGQPIQKLIPAHGGGEPGYPLSQQTGFRNAHLAIYSPGLVLCLHTDRDPAFRHRLSALSFRPLSLLRQETKYQSYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H1H7</accession>
    <name>A0A3S1H1H7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SMB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_021914</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001438">
        <property type="protein sequence ID" value="RUS70325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6056922at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053231">
        <property type="entry name" value="GPCR_LN-TM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001212">
        <property type="entry name" value="Somatomedin_B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902:SF1">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01033">
        <property type="entry name" value="Somatomedin_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00524">
        <property type="entry name" value="SMB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50958">
        <property type="entry name" value="SMB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018542086" description="SMB domain-containing protein" evidence="4">
        <location>
            <begin position="33"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="959"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="990"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1023"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1066"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1112"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1173"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1198"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="domain" description="SMB" evidence="5">
        <location>
            <begin position="313"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1264"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS70325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1285" mass="140627" checksum="3A07E730D13C59CB" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H1Z4</accession>
    <name>A0A3S1H1Z4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_021646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001373">
        <property type="protein sequence ID" value="RUS70600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H1Z4"/>
    <dbReference type="STRING" id="188477.A0A3S1H1Z4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS70600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="106" mass="12021" checksum="C52FBF0281AF6AE3" modified="2019-04-10" version="1" fragment="single">TEYGGERTEYGGERTEYGGERTEYGGERTEYGGERTEYGGERTEYGGERTEYGGERTEYGGERTEYGGERTEYGGERTQYGGERVLRLVGLFPYHIGLQVHANFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HAU3</accession>
    <name>A0A3S1HAU3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_016646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000727">
        <property type="protein sequence ID" value="RUS75582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HAU3"/>
    <dbReference type="STRING" id="188477.A0A3S1HAU3"/>
    <dbReference type="OrthoDB" id="10267127at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006798">
        <property type="term" value="P:polyphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00144">
        <property type="entry name" value="MPP_PPP_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050126">
        <property type="entry name" value="Ap4A_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42850">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42850:SF4">
        <property type="entry name" value="ZINC-DEPENDENT ENDOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="51"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS75582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="299" mass="33366" checksum="F10312CEEAE31399" modified="2019-04-10" version="1">MAALLFNSLSLVRDTSQRLLLLAKNSVYGASSKSNCHHEVVTQSQIGDRDILIVGDIHGCYDEFEELIGVARESVNGRELYTVCAGDMLNKGPKSKKVLDFLRDLMMRGMASAVKGNHEEAILRQYRLLTKDKHYVLPKRYTYLNEFNQDDFAFIERLPYSVSIPHLNVLVVHAGLVPGVPLERQSCENLCEMRNVEVSITFPWGLVSTAHKKPVRGVAWASAWQGPQHVYFGHDCRRGLQRLPFATGLDTGCVYGDRLTGAILDACSGSARLVSVEAKREHYCGKKQAMSGEQNVEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HFQ7</accession>
    <name>A0A3S1HFQ7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_013784</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000508">
        <property type="protein sequence ID" value="RUS78461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HFQ7"/>
    <dbReference type="STRING" id="188477.A0A3S1HFQ7"/>
    <dbReference type="OrthoDB" id="10036964at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF233">
        <property type="entry name" value="THYROTROPIN-RELEASING HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="65"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="396"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="402"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="425"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS78461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="482" mass="54005" checksum="2CA8E561F34B682E" modified="2019-04-10" version="1">MPERLDQNSKDTSVVPEGIVVSSHFPNSSEANSSGNISDVPALPAYITIYVTILNLVIFVVGVVGNILVILVMSRVREMRTSINIHLANLSVADLLVLLVCQPAALIEFYAKDRWYLGPFLCKLVPVLEHSVIHASTLTILVISCERYHAICRPLKSFLLCNKPRPLPVVMCVWGAAVLTSLPFLAMTSLEDSWFYDGSPCQVCSTKTYLKWHYVYVLAILVVFFLLPFLLLFGMYGNIIRHLHRRMLGGQGELARLGNECSSGDASGSFDEGSLRARRQVIRMLLAVVCLFFFSLAPIRAFIMWRMFVSKDSLNSLGMEKYFNLLWICRMFTYVNSTGNPIIYSLMSSNFRKAFTLLLQGRINSATPSTGTTGSLRRVSVSVALKRMSLQSITVGDGSRSLVRNTRGSRDSTSTPHGPHTKDDNYDDYDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDYDDNNNDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HHR0</accession>
    <name>A0A3S1HHR0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Spectrin beta chain, non-erythrocytic 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Beta-III spectrin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EGW08_012629</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">EC2010</strain>
            <tissue evidence="15">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Probably plays an important role in neuronal membrane skeleton.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the spectrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000440">
        <property type="protein sequence ID" value="RUS79604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HHR0"/>
    <dbReference type="STRING" id="188477.A0A3S1HHR0"/>
    <dbReference type="OrthoDB" id="5865767at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051693">
        <property type="term" value="P:actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21246">
        <property type="entry name" value="CH_SPTB-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21248">
        <property type="entry name" value="CH_SPTB_like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000020">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000003">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000004">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000083">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000106">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000229">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0117">Actin capping</keyword>
    <keyword evidence="7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="14">
        <location>
            <begin position="46"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="14">
        <location>
            <begin position="165"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1118"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="449"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="775"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="987"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RUS79604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1138" mass="132409" checksum="D41D1686B73FEE9F" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HIX9</accession>
    <name>A0A3S1HIX9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Calx-beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">EGW08_011880</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">EC2010</strain>
            <tissue evidence="22">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>Ca(2+)(in) + 3 Na(+)(out) = Ca(2+)(out) + 3 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:69955"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000396">
        <property type="protein sequence ID" value="RUS80362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HIX9"/>
    <dbReference type="STRING" id="188477.A0A3S1HIX9"/>
    <dbReference type="OrthoDB" id="418484at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005432">
        <property type="term" value="F:calcium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2030">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051171">
        <property type="entry name" value="CaCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003644">
        <property type="entry name" value="Calx_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004836">
        <property type="entry name" value="Na_Ca_Ex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032452">
        <property type="entry name" value="Na_Ca_Ex_C-exten"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00845">
        <property type="entry name" value="caca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11878:SF65">
        <property type="entry name" value="NA_CA-EXCHANGE PROTEIN, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11878">
        <property type="entry name" value="SODIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03160">
        <property type="entry name" value="Calx-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16494">
        <property type="entry name" value="Na_Ca_ex_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00237">
        <property type="entry name" value="Calx_beta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141072">
        <property type="entry name" value="CalX-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="18" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="21">
        <location>
            <begin position="396"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="21">
        <location>
            <begin position="525"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00033667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="RUS80362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="600" mass="66438" checksum="6ABBD444D4D75434" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SK86</accession>
    <name>A0A433SK86_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_022698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001649">
        <property type="protein sequence ID" value="RUS69540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SK86"/>
    <dbReference type="OrthoDB" id="6202475at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS69540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="218" mass="25088" checksum="1D748CBC3EB0F75B" modified="2019-05-08" version="1">MNNGDLPVCPPAPVKRRDQPRSRPNLQDEPHLDCARRICYDAHDDSRPVTQALAPKKKSPTAELSLRANQGILPRPFQSRARRNIMRSLRTYRNMVRIFGVEDPAVNWINLNTIHTIQINRAGNLPGPAKPRKSRDEATSESENWPETTKRREDWTSATVKVKRTPMTVALHPDNRFLLRNELVDLYATLINLIKNYKEKKQIMDNFALLFWGKSSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SL20</accession>
    <name>A0A433SL20_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Clarin-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_022405</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the clarin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001561">
        <property type="protein sequence ID" value="RUS69836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SL20"/>
    <dbReference type="STRING" id="188477.A0A433SL20"/>
    <dbReference type="OrthoDB" id="10012538at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026748">
        <property type="entry name" value="Clarin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31548">
        <property type="entry name" value="CLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31548:SF1">
        <property type="entry name" value="LD47387P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25807">
        <property type="entry name" value="Clarin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS69836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="24810" checksum="241598A1E00FEC88" modified="2019-05-08" version="1">MVSAQRKWIGVSIFIAAIGVGFIVAAFATDHWIISEPRGNETNQNSTGGSSSGYTANITFGLFAGSRSIDYGIGIRSQNLISHLSEHWFGLFSLPLYVATLVMLVLAIVWGLVAVGFAIFNLFGRPIETITGPSGLYLWNILALVNSLAAIGVYLGLYFSQFEENILQQDALGAGFTSDGLTDLDYSFYFLVGAGAAFLVNIGILLISDRKCSCSFSGSAEKEVDNGMILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SL25</accession>
    <name>A0A433SL25_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">M-phase inducer phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_022406</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the MPI phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="6"/>
    <dbReference type="EMBL" id="RQTK01001561">
        <property type="protein sequence ID" value="RUS69837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SL25"/>
    <dbReference type="STRING" id="188477.A0A433SL25"/>
    <dbReference type="OrthoDB" id="9999371at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110032">
        <property type="term" value="P:positive regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009794">
        <property type="term" value="P:regulation of mitotic cell cycle, embryonic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01530">
        <property type="entry name" value="Cdc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000036">
        <property type="entry name" value="M-phase inducer phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000751">
        <property type="entry name" value="MPI_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF76">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00716">
        <property type="entry name" value="MPIPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 6" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4 6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="8">
        <location>
            <begin position="314"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS69837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="461" mass="51900" checksum="EF4AF2846F732E2E" modified="2019-05-08" version="1">MENNKSSPENDSFSSKRLFLENSGLTSRQNSQASSSRSVQRGNDGHLMPPPAAPTSAPHFHSAQNVPDFIPFISPSKEGEVPMEFSPGIKRHNKDGSNTPGTPTSLFKALTTKTTPESKSAITNSSEMQPAEVFKSPGSPSSEFKAMLDAIDVQESPSGSNDDNFLRRQEKPNLRRCRSLEMRKRLFDMSNTPPNAFKPVFKRPACVDSGDQAYTKLAKRPKDLKLWGIKESSASPLVKEQCEEKSSQDKPCNPGEVLDHERIKVAVDALQSPDVIGDCSREHCLPLINGKHNDLKNISHETMAHLLNHGYQDKFNRLTVIDCRYPYEYKGGHIKGAINLYTEDDIDLFLKKEVLEAIGTKSKTHILVFHCEFSSQRGPGLLRYLRKLDRQMNIHQYPLLTFPEVYVLHLGYKEFFHNHPHLCDPSAYVPMADESYIEDLKHFRAKAKSWTAGERGGSFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SQG4</accession>
    <name>A0A433SQG4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial inner membrane protease ATP23</fullName>
            <ecNumber evidence="6">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_020767</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="6"/>
    <dbReference type="EMBL" id="RQTK01001206">
        <property type="protein sequence ID" value="RUS71468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SQG4"/>
    <dbReference type="STRING" id="188477.A0A433SQG4"/>
    <dbReference type="OrthoDB" id="285308at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019165">
        <property type="entry name" value="Peptidase_M76_ATP23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21711">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21711:SF0">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE ATP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09768">
        <property type="entry name" value="Peptidase_M76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS71468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="255" mass="28950" checksum="A14B8FF4E7BF13AF" modified="2019-05-08" version="1">MAASSNSKSNSTDTEADKKSPKGLVTDDEDYGYYFYPEREEKKKKSYFERVLSRDDASNFTCRMNVQTCMEKNPMVKLMVGALSSHGCPVDMKRHISCEPCLAKVSGGFDPKTMQVVLCQNNIQNKDVCCNVLAHELLHAFDFCRAKVDFENLRHLACTEIRAANMNHCSLAAAYAIGEASLFGVKERHQLCVKNKALQSILLVRNVPKEEAMIAVDEVFDRCYSDTEPYGRRCFKSMPRAKRALDEARNYYDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SQG7</accession>
    <name>A0A433SQG7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_020734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001204">
        <property type="protein sequence ID" value="RUS71483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SQG7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS71483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="456" mass="51179" checksum="3CE7679C5C1A94F9" modified="2019-05-08" version="1">MSRRADAVIYVPKCCLICLEYKTTDKPLTEPTASHVLQLKETYSNVLANLSKRITKELNGKLGNLIPILIDYTKHNDDQEVLCLVLGSGEGINVDTKVQPDEKTFERVMIKKIGYDSNAIISTDFAVSISLDDNSELSDRNVNDMNEKLIPFTLDESMKILNPFCENFDNVADCVTMELCVSKQKVNTPPPTMSISGTEESVPVNLTIKQRTKEFVLNSRPPTPRTSLNEVGVGRRNFIIQQETMIKSAQPKTIRCMWDACQDKLVFHSIFVPVTTKSLDFYIGFVPMLQNGAGFEKHESILLKYIPRLSIVQCPHSVLTNVPIDLRSAVNKMNCPCVMKFGKKVLFLKIHDLLYKHVCKTFDSWGKLVNLYMDNAKNISDASFRNDSSLESTSTDGDLNNRVSQQMKIWTDDFKQQVGICNQHELGKSHIVAAVAAKRRADSPADGSQKSKSAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SRB8</accession>
    <name>A0A433SRB8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_020449</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001158">
        <property type="protein sequence ID" value="RUS71796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SRB8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS71796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="110" mass="12593" checksum="2D48153BD1E6150C" modified="2019-05-08" version="1" fragment="single">NSVDETNCSHKEQEGHEEVRVAIKLELSWLREQNRADKLAFGSGPTCSQHNSLHLLVAIETCLDHMSPAEEHMARVVLEIKVWLLDIWIQTPGHTAWVWQGRLGDWNTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SW92</accession>
    <name>A0A433SW92_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_018664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000922">
        <property type="protein sequence ID" value="RUS73573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SW92"/>
    <dbReference type="STRING" id="188477.A0A433SW92"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="853"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="856"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="870"/>
            <end position="881"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS73573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="921" mass="102110" checksum="19487F4687BE45F6" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SWC7</accession>
    <name>A0A433SWC7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Crossover junction endonuclease MUS81</fullName>
            <ecNumber evidence="13">3.1.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EGW08_018638</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">EC2010</strain>
            <tissue evidence="16">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with EME1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the XPF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.22.-" evidence="13"/>
    <dbReference type="EMBL" id="RQTK01000919">
        <property type="protein sequence ID" value="RUS73595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SWC7"/>
    <dbReference type="STRING" id="188477.A0A433SWC7"/>
    <dbReference type="OrthoDB" id="5963188at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048257">
        <property type="term" value="F:3'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21036">
        <property type="entry name" value="WH_MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20074">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000307">
        <property type="entry name" value="Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000003">
        <property type="entry name" value="Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.110:FF:000001">
        <property type="entry name" value="Putative Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033309">
        <property type="entry name" value="Mus81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047417">
        <property type="entry name" value="WHD_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047416">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451">
        <property type="entry name" value="CLASS II CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451:SF0">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21292">
        <property type="entry name" value="EME1-MUS81_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21136">
        <property type="entry name" value="WHD_MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 13" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 13" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="15">
        <location>
            <begin position="669"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="115"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="386"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="437"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="535"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="447"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="535"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RUS73595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="952" mass="103972" checksum="F2B3BAF62E809154" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SXD3</accession>
    <name>A0A433SXD3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_018318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000885">
        <property type="protein sequence ID" value="RUS73928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SXD3"/>
    <dbReference type="OrthoDB" id="6484170at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019167729" evidence="1">
        <location>
            <begin position="19"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS73928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="292" mass="32009" checksum="644DAC8666E189D0" modified="2019-05-08" version="1">MKVAALLVFTAVFSAACGAAIEKRQLDDYFDAFAAIGQNTLSDLLDLANRGWADLKQKIKDYDIHTRYNQIKDKLVAKYGGVFQTISTFSFDTIADAVTNVLANAVGLQDIASIVKKVRAVLGKDADSVDDTELGEIVKEVEDDITSGGDDAVAKRAIFDTFGGIYRNLTAIGRNAYSDLFNLARQGWNDLKQKIQDYDIKGRIATIRQKATDRYGPIFDKISSLRFEHIVDEAKKVISTAADILDVKAVVGQIRAGLGAEVEDIPDEEIEDIIKVVEEDVISEPVPTPSMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SYY9</accession>
    <name>A0A433SYY9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PI4-kinase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_017723</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000824">
        <property type="protein sequence ID" value="RUS74516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SYY9"/>
    <dbReference type="STRING" id="188477.A0A433SYY9"/>
    <dbReference type="OrthoDB" id="7381062at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045495">
        <property type="entry name" value="PI4K_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19274">
        <property type="entry name" value="PI4K_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI4-kinase N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS74516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="184" mass="20204" checksum="C2785EAE73D3B3A3" modified="2019-05-08" version="1" fragment="single">ERIEIAKYSDSQQIKIFLSLLNKSLSVQIGHRPSIISRHTAAIGPRFRLLSMGLSLLQGDNLPNTPAKTVLRERVYAATLDFFCGPPICPSQAPIELRGDITLLMQYWQRMHYDKKHLSVNTVPLADTMENNPASTSPPMTSGSGAAYSVQSGWMNTFNSNSSSIYSKRSATGETRPTQSSQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SZ63</accession>
    <name>A0A433SZ63_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_017631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000815">
        <property type="protein sequence ID" value="RUS74609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SZ63"/>
    <dbReference type="OrthoDB" id="8964250at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS74609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="366" mass="40250" checksum="EEA933A24A23EA26" modified="2019-05-08" version="1">MTEEADLQTLAVNRALQKKQNLVLKAPDKPQTSPRQAPDKPQTSPRQAPDKPQTSPRQAPDKPQTSPRQAPDKPQTSPRQAPDKPQTSPRQAPDKPQTSPRQAPDKPQTSPRQAPDKPQTSPRQAPDKPQTSPRQAPDKPQTSPRQAPDKPQTSPRQAPDKPQTSPRQAPDKPQTSPRQAPDKPQTSPRQAPDKPQTSPRQAPDKPQTSPRQAPDKPQTSPRQAPDKPQTSPRQAPDKPQTSPRQAPDKPQTSPRQVPDTPHTSARQAQDKPQTSPRQAPDKSQTSPRQTPDKPFICIRGLAIYTTKRVPIILLFFVGINKPGKGFTYDLEGGGELAQLAVHSDWESRGCWSGEQNVRSVGSELKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T646</accession>
    <name>A0A433T646_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_015172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000613">
        <property type="protein sequence ID" value="RUS77060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T646"/>
    <dbReference type="STRING" id="188477.A0A433T646"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS77060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="293" mass="35283" checksum="32A326108D0912DB" modified="2019-05-08" version="1">MSWKKRRREGEKKELRVGERKRRREKEEEQEGGRKEGRSAAGGRKRTEKEQEGRGRGAAGIMTRMREKELEKVRTGRTREKEMEEVRTIRREKELEEVKTGRTREKEMEEVRTGRTKEKELEEVKTGRTREKDLEEVRTGRTREKELEKVRTGRTREKVRTGRTREKVGTGRTREKVRTGRTREKVRTGRTREKELEKVGTGRTREKVRTGRTREKELEKVRTGRREKEMEEVRTIRREKELEEVRTGRTREKDLEEVRTKRRGEEQEGRKNKGMTRVRKIRGRESRSREINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T9M5</accession>
    <name>A0A433T9M5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_013966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000521">
        <property type="protein sequence ID" value="RUS78275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T9M5"/>
    <dbReference type="OrthoDB" id="10650237at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="632"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="701"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="642"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="707"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS78275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="838" mass="94921" checksum="93765E7A06249B02" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TA64</accession>
    <name>A0A433TA64_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sialate O-acetylesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_013824</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000511">
        <property type="protein sequence ID" value="RUS78410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TA64"/>
    <dbReference type="STRING" id="188477.A0A433TA64"/>
    <dbReference type="OrthoDB" id="42638at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001681">
        <property type="term" value="F:sialate O-acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005181">
        <property type="entry name" value="SASA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039329">
        <property type="entry name" value="SIAE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22901">
        <property type="entry name" value="SIALATE O-ACETYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22901:SF0">
        <property type="entry name" value="SIALATE O-ACETYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03629">
        <property type="entry name" value="SASA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019005541" description="Sialate O-acetylesterase domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Sialate O-acetylesterase" evidence="3">
        <location>
            <begin position="135"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS78410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="544" mass="60227" checksum="95833981EFA1B0CF" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TAF0</accession>
    <name>A0A433TAF0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_013694</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000503">
        <property type="protein sequence ID" value="RUS78551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TAF0"/>
    <dbReference type="STRING" id="188477.A0A433TAF0"/>
    <dbReference type="OrthoDB" id="441329at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22435">
        <property type="entry name" value="KH-I_NOVA_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22436">
        <property type="entry name" value="KH-I_NOVA_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09031">
        <property type="entry name" value="KH-I_NOVA_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000022">
        <property type="entry name" value="RNA-binding protein Nova-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047275">
        <property type="entry name" value="KH-I_NOVA_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047276">
        <property type="entry name" value="KH-I_NOVA_rpt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047274">
        <property type="entry name" value="KH-I_NOVA_rpt3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="9">
        <location>
            <begin position="88"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="9">
        <location>
            <begin position="186"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="9">
        <location>
            <begin position="529"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="442"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="444"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS78551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="615" mass="64658" checksum="6E0FAFE72D4D49F0" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TE05</accession>
    <name>A0A433TE05_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_012433</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000427">
        <property type="protein sequence ID" value="RUS79786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TE05"/>
    <dbReference type="STRING" id="188477.A0A433TE05"/>
    <dbReference type="OrthoDB" id="10046198at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000037">
        <property type="entry name" value="B-cell lymphoma/leukemia 11A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000106">
        <property type="entry name" value="B-cell lymphoma/leukemia 11A isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051497">
        <property type="entry name" value="Dev/Hematopoietic_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45993">
        <property type="entry name" value="B-CELL LYMPHOMA/LEUKEMIA 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45993:SF6">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="190"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="354"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="222"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="372"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS79786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="463" mass="50342" checksum="1874EF53F8AC0DB3" modified="2019-05-08" version="1" fragment="single">VSSSSPRLDHRPVSASSVAASSPYHVTHAPNPFTSPFRLPGVTPPTSLSPYGRTPTSGLDFDLITDYRLRPQFLASRAGLEAGAVPFPHPGHAFHERARAAHISPVQLDYDFYSMRLKQTDGSPGGNTALCATPAGGGLVLPPKLKACEFCGKSFRFQSNLVVHRRSHTGEKPYKCPLCPHACTQQSKLKRHMKTHAATKAGAASDGDDALSEAGQARKDDAEDDEDDEEEEEEEEEGEEEEEDEEEIMEEEMNDEEREVLEQMKKAETSEEQAVPEPGEIRHAAKRIKLERGHDAPENGQEQDEEEEEEEKPSDLSIKRQPAAESVLSEVMKNSGLASIQTYTEAYEAALAENQVNGQDAAHGRKDKGSSGRRSSGPEGRSGSPRQGVKRERDADTEKDSGRKEHLFLGGTDLLAKVGKAAAHPGWPASLDGLSPHPAALDPACASAWRTGTRTSWARTRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TIK1</accession>
    <name>A0A433TIK1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_010883</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="RQTK01000342">
        <property type="protein sequence ID" value="RUS81351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TIK1"/>
    <dbReference type="STRING" id="188477.A0A433TIK1"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120025">
        <property type="term" value="C:plasma membrane bounded cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004679">
        <property type="term" value="F:AMP-activated protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12122">
        <property type="entry name" value="AMPKA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14079">
        <property type="entry name" value="STKc_AMPK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14336">
        <property type="entry name" value="UBA_AID_AMPKalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000079">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000136">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032270">
        <property type="entry name" value="AMPK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049020">
        <property type="entry name" value="PRKAA1/2_AID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16579">
        <property type="entry name" value="AdenylateSensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21147">
        <property type="entry name" value="AMPK_alpha_AID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="17"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="463"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS81351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="523" mass="59207" checksum="A1B4C3ECBEB99090" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TIP1</accession>
    <name>A0A433TIP1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane protein 134</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_010807</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM134/TMEM230 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000338">
        <property type="protein sequence ID" value="RUS81423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TIP1"/>
    <dbReference type="STRING" id="188477.A0A433TIP1"/>
    <dbReference type="OrthoDB" id="10048380at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039714">
        <property type="entry name" value="TMEM134"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008590">
        <property type="entry name" value="TMEM_230/134"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13558">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13558:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05915">
        <property type="entry name" value="TMEM_230_134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS81423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="14846" checksum="8744C0FE16E6DAE6" modified="2019-05-08" version="1">MKEPLLSAAPVPESNHDTSKSASGRPSSFRSILPSGSADSHSNYSATSFSNQDSWIKHPKVKENWRTVIASAVLSILGITLLTTGIVVAFTPAIGYQCLIFGTIGLLCLIPGGYHFIYIYCAAVGRPGYDFENLPVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TJ21</accession>
    <name>A0A433TJ21_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_010722</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000333">
        <property type="protein sequence ID" value="RUS81515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TJ21"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019456050" evidence="2">
        <location>
            <begin position="29"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="348"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS81515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="361" mass="42249" checksum="42C0D0131C037310" modified="2019-05-08" version="1">MHDSTGKIAGRFFIANVLLCTMFWIDDDDDDDDDDDDDDDDDDDDDDDDDDGDDDDDDDDDDEEEEEEEEEEEEIRGEGGFFFKIMIMARCQNNKNNDGRREARSFTPHLGKLWIKLVHLQYGACGRALGSQMGGTWLEEKMCCLWWSGLELPEMIVFHLCQVRQGQTPYSYRLLEPGNNYNIFGGGDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDANGQADALSSSKVNSGHRGRYHCRSGLDEFSFQPDRAEVNWVGYFPHFEFLLKEKEGKEQEGEKEKKREKEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEKKKERKKERRKYSINNDQPYNNCKNSNKNNTEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TKZ5</accession>
    <name>A0A433TKZ5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_010063</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000299">
        <property type="protein sequence ID" value="RUS82181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TKZ5"/>
    <dbReference type="STRING" id="188477.A0A433TKZ5"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018969292" evidence="2">
        <location>
            <begin position="19"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="4">
        <location>
            <begin position="25"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="716"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="746"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS82181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1169" mass="134148" checksum="CD1692F571E042DF" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TPE3</accession>
    <name>A0A433TPE3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_008761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000242">
        <property type="protein sequence ID" value="RUS83445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TPE3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019549259" description="Secreted protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS83445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="16755" checksum="0F8A38A1BEE344C8" modified="2019-05-08" version="1">MRRLILLCLLVRLFSRGLCVRKPPPPPDSRPGTFKPPRPQTKPVLEREAAFQRDRAGPLVSDPSGVCKTCFAVRSAANSTQNSLIQCMQRCASSLRSGKPKSILFHPSEKHGCCDDCKNASGRSTKNKQGSWVRYIQTSAKPKDSWTTDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TQY9</accession>
    <name>A0A433TQY9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_008237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000221">
        <property type="protein sequence ID" value="RUS84015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TQY9"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS84015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="171" mass="18755" checksum="AE0530A93379E104" modified="2019-05-08" version="1">MKAPCSLSISLTPFIYLYLSPYHSLLLSISISLHITRSFYLSLSLSISLAPFIYLYLSPYHSLLLSISISLHITHSFYLSLSLSISLTPFIYLYLSPYHSLVLTISSSLHITHSFYLSLSLSISLAPLIYLYLSPSPSISLSGASLSLSLSIYGLSLTTSNSNSVSLCLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TS84</accession>
    <name>A0A433TS84_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_007818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000206">
        <property type="protein sequence ID" value="RUS84434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TS84"/>
    <dbReference type="STRING" id="188477.A0A433TS84"/>
    <dbReference type="OrthoDB" id="431202at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022127">
        <property type="entry name" value="STIMATE/YPL162C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735:SF1">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12400">
        <property type="entry name" value="STIMATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS84434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="266" mass="30213" checksum="78F9992B6CEC9920" modified="2019-05-08" version="1">MVESAPVWNKENELHCDHGDLRGLLGLFVQALLAFLAFTSLIVKRYCEPRHSRRPWIIWFFDTSKQGVGAAVLHFANLYLSEVFQGDPCTWYFISFLLDSTFGLLVIYVGLRTCQHVSHRYAWKSLYFGEYGDPPTCHAWMGQCALYILVMVVTKLLMTALMLLRFWAKVRKFLMAPITSPDLEIVLVMFIVPLVVNALVFWVTDNFLKQSLAAPKTMYVTSGQEGGARYFHQLGSVKCYSRIEACEADCDLILSGDDDAGDKLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TUG1</accession>
    <name>A0A433TUG1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_007046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000178">
        <property type="protein sequence ID" value="RUS85220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10619943at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="694"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="979"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1088"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="696"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="979"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="994"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1028"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1090"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1113"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS85220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1286" mass="137115" checksum="A9EC7386F5C041BF" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TW08</accession>
    <name>A0A433TW08_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_006467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000160">
        <property type="protein sequence ID" value="RUS85753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TW08"/>
    <dbReference type="STRING" id="188477.A0A433TW08"/>
    <dbReference type="OrthoDB" id="10038545at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48209">
        <property type="entry name" value="AGL056WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48209:SF2">
        <property type="entry name" value="FI24008P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS85753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="34427" checksum="2325C8A0005F4D0B" modified="2019-05-08" version="1">MRKRINMYLRKDDTFFHYLNTGTKYKSNDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDGGGGGGGPVIEETRESDGQPARKLWKFKVCTAHHVVFNTEEAKETNVDLFYDDDIDCSKPGGKMETVRGLEVVQSFPENDVCLFWCMTYDEALGERLETSWRCWWVGRLKPLDLSGLDYLPSCGIDVRRTLIVSHPHGKPKKIAIGEGTVQDHPLIQYNTATCPGSSGAPVFGFVINPAERRNLRWFPPVHSGSHTKTSTQQQEELFTDETEGQKTTLAQRNFGNRWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TY63</accession>
    <name>A0A433TY63_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_005711</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000136">
        <property type="protein sequence ID" value="RUS86519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TY63"/>
    <dbReference type="STRING" id="188477.A0A433TY63"/>
    <dbReference type="OrthoDB" id="71307at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF77">
        <property type="entry name" value="LD25952P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="3">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="187"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="383"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="430"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="234"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="250"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS86519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="486" mass="53009" checksum="C8910A1A6BD56040" modified="2019-05-08" version="1">MLKFYSYFKQATEGPCTSAKPGFWDVVNRKKWEAWAKLGRMEAEEAMLLYVDELKKVSKHVRTVYYPPEIVETMPQTDDVSEFLQKLDNFYEMVEDSDNHNSLKVYDKESPHGDPDDHPFDCSFNGSPGIESEFEHSQGITKLLQQDICWWQNSRGLVKAHKANGDINHGERERKEVIHESLSIEHVIHTDRGRGENRTGEIPAYDPEGETNPPDTPGTPGTEEEWEEVEARASNSGSHSGQSGGSLSDSETENEEEFCDTSDEPVETIHPQEVSAVSTPTPTQIRTQPALLLNPVISASSSSLLTSATPTSMVKSVHFDEHHAVTAPMTSKRLAALQGSTPSRARGELSDSLLVNPSPQTGRLMDVTAVTAPMTSKRLAALQGSTPSRARGELSDSLLVNPSPQTGRLMDVTSSSLTEGCSEVVSVGNQTMEENSSDDVGVGRTGSKMDISVCRGGDGEEGDRDRMAQGSVGRFGRDGIPQGRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TYJ8</accession>
    <name>A0A433TYJ8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_005646</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000133">
        <property type="protein sequence ID" value="RUS86630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TYJ8"/>
    <dbReference type="OrthoDB" id="6148240at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="4"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS86630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="295" mass="33141" checksum="C16FBEB9462347CB" modified="2019-05-08" version="1" fragment="single">GLISNIINIVIFLKAGVKDNVTTLLLSLALSDLVFIALITPSACALVILNFAKYWPWPFDGMFLYFLPYWPAFTAYDLSAFISVALGVMRCACVAMPLKFKVVFTRTRTIRFVLFLVVLAVSLRVPVLTIFRVMHRADPVTNSSVLHVVAVNRKAMSRINDVMNRGVIIWVKYAIMVSCVGILSFKLAQASRIRRSCTETASQAGEKNTKEGLAPKDLQVIKSVVLVCTIFILSQLPFLLSSTARLITPQYTSNGQMRYLYNSISTISLFCSYLNASINIFVYYNFNSKYRFVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TZP4</accession>
    <name>A0A433TZP4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_005202</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000121">
        <property type="protein sequence ID" value="RUS87049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TZP4"/>
    <dbReference type="STRING" id="188477.A0A433TZP4"/>
    <dbReference type="OrthoDB" id="2014092at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF544">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR002419-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS87049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="290" mass="31970" checksum="0416928F92FC5E62" modified="2019-05-08" version="1">MDNDLINTISGKDVIMAYGRGRRSYKEHVGPESSCSGLFWCRYCLFFLNLIVWAAGIAMICLGAWTVANGAGLKLFDQLLNEPSYLLIGTGVAMVIVGVYGCVASVKVNAWGLRIFMLVVIALFIVQVVLGAIGFFLMDDLRTDMSDIVRKAVVYYRIDNNLSRDEDMNALQIDFKCCGGHSFSDWEANILYSCNSSSALARCGVPKSCCRGTRDAQCGYNVREATEQYTAMFTYTEGCIVTLLKVIKRHVSIVAGLAFSVSILEIICLVLANIIIKNTVYHRKLLPSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U1V9</accession>
    <name>A0A433U1V9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_004451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000101">
        <property type="protein sequence ID" value="RUS87786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U1V9"/>
    <dbReference type="OrthoDB" id="6162180at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS87786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="121" mass="13710" checksum="B58D563E5939B598" modified="2019-05-08" version="1" fragment="single">AHRLLVEAKKSSRFDQVSSVSKWRKVLDKYKQRMKSLNCHLTKKDEMMGGTSSRLSVLRAEIRDALLSVRSSTSTKERLNTQCKLNAALMDVIESKSENPSYGSDLDHQGCVLKQEQRGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U3A0</accession>
    <name>A0A433U3A0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_003994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000089">
        <property type="protein sequence ID" value="RUS88228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U3A0"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS88228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="144" mass="16396" checksum="763341EF90513943" modified="2019-05-08" version="1" fragment="single">PPLPSSSSSSSSLHHHHHHHSLPHHPHHLQLSQHHPRQHPHLHHNHHHHQQQQQQQHSQQHVLHLHNNNNNIAAASASSTPTPEEDADQQRHLMDALKMMSNFAARKSLGDQVQSALRTIEMTMKNNARKSSSATRGSYPNNMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U448</accession>
    <name>A0A433U448_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_003621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000078">
        <property type="protein sequence ID" value="RUS88595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U448"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS88595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="203" mass="20437" checksum="E05753F11AFAD60D" modified="2019-05-08" version="1">MRALHARACGYRAGKVKASLVVSSRGEHGTQHMINIHTHTEHRPSMSSPGPEQAAGLAEKKKKKKKKKKKKKKKKKKMTIRSPGSPYCLCFSIGPPIGPGMGPPIGPPIGPPIGPPIGPPIGPPIGPPIGPPIGGPCMGPPIGGPCMGPPIGGPCMGPPIGGPGMGQLIGGPDMGPGIIPSLGPVIIGSLSMGAGMVGVLDMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U484</accession>
    <name>A0A433U484_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Neurotransmitter-gated ion-channel ligand-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">EGW08_003626</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">EC2010</strain>
            <tissue evidence="18">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Synaptic cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000078">
        <property type="protein sequence ID" value="RUS88600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U484"/>
    <dbReference type="STRING" id="188477.A0A433U484"/>
    <dbReference type="OrthoDB" id="6073255at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000028">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="16">
        <location>
            <begin position="50"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="17">
        <location>
            <begin position="259"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="202"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="425"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="438"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="457"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="533"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="561"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RUS88600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="601" mass="68422" checksum="E83A8DD44BB458B9" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U4W5</accession>
    <name>A0A433U4W5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BRISC and BRCA1-A complex member 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Mediator of RAP80 interactions and targeting subunit of 40 kDa</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">New component of the BRCA1-A complex</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EGW08_003389</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">EC2010</strain>
            <tissue evidence="17">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BABAM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000072">
        <property type="protein sequence ID" value="RUS88844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U4W5"/>
    <dbReference type="STRING" id="188477.A0A433U4W5"/>
    <dbReference type="OrthoDB" id="547311at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070531">
        <property type="term" value="C:BRCA1-A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070552">
        <property type="term" value="C:BRISC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045739">
        <property type="term" value="P:positive regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21502">
        <property type="entry name" value="vWA_BABAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026126">
        <property type="entry name" value="BABAM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15660">
        <property type="entry name" value="BRISC AND BRCA1-A COMPLEX MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15660:SF1">
        <property type="entry name" value="BRISC AND BRCA1-A COMPLEX MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RUS88844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="293" mass="32922" checksum="40DA100DAE1603CC" modified="2019-05-08" version="1">MSNMNAAATAESPVDSGGSKQESLSQQSLQGENMKGNITSHLPSIPLPNVDCPEKIIICLDLSQEMNTTTFRSRAGDKYSGLELAKRAIKMFVAHKSQMNPKHQFAFLVFKEEATMIHSFTTKAQDVLQTLDESEIEPQESDSFNLTHFFETIKENIDLPEVQGDPRVVPPPYVVRVLLVFGRSHSVPVSPCQKVQRELESSPYFFTDVLYIHEPPSEENKCEEIFHLFCELDHNGMSYIFEQSKYTPILSSGAKLLAHPLQRPRQLDAVYKIGSPVPTPVPQPVVSVDERVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U573</accession>
    <name>A0A433U573_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GPR158/179 extracellular domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_003297</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000070">
        <property type="protein sequence ID" value="RUS88961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U573"/>
    <dbReference type="STRING" id="188477.A0A433U573"/>
    <dbReference type="OrthoDB" id="2129233at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043458">
        <property type="entry name" value="GPR158/179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054714">
        <property type="entry name" value="GPR158_179_extracellular"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32546">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 158-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32546:SF29">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22572">
        <property type="entry name" value="GPR158_179_EC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="GPR158/179 extracellular" evidence="10">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS88961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="117" mass="13273" checksum="1EBD517095DB9FDE" modified="2019-05-08" version="1" fragment="single">NVFAGSSRCRPETTECEHIPGLGFRRGSYKCVCKKGYYFPDPTARDKFYTGTDVEHEYEKKRKGLANRYHRDFQCLPCAPGCDSCDDPSPCILALNWILRSILLTISGLIMSFLLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U6G9</accession>
    <name>A0A433U6G9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_002794</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000056">
        <property type="protein sequence ID" value="RUS89421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U6G9"/>
    <dbReference type="STRING" id="188477.A0A433U6G9"/>
    <dbReference type="OrthoDB" id="10250549at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04652">
        <property type="entry name" value="LbH_eIF2B_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051960">
        <property type="entry name" value="eIF2B_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="10">
        <location>
            <begin position="9"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="EIF2B subunit epsilon/gamma LbH" evidence="11">
        <location>
            <begin position="369"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS89421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="479" mass="52482" checksum="B6227E7D068888F2" modified="2019-05-08" version="1">MSNPGNITAVIMAAGMGSRMTDLNTECPKALLPVGRYPMIWYPIRTLEKSGFSEIIIITRQSWQDQLASTLNSGKMSIHAKLEFLAIPDQEDIGTADSLRHIADRVKTNALVVSCDLITDSDLLDLMSVHRKNNSCLTVMLSQLPNSLTADTVVPGFKAKQKSNSGEKISIGFEYNNLEHIVYWKAQVDMEDEFVTFSKKFLNRFPCARIQSNWTDCHVYLIRDFVIKYLKDKSDISSVQGELVPLAVKKQMSVFLPILPQEESSMASPGGDMKVDKKKDLIDYAGETSNHLSHIIQSLSLTSPSFGTNEDAPRKNLIGCFAYRQTEGFCVRANTIAAYAEASKQMPRLTSNFLPTKQKAGPNVPEGTVIKPKSQVGADSMLGENVTIGEKVSIKKSVLGKNCSVGDGVKITNSVIMDGVSISQNCIISNCIVSQSAKIETGCQLSNCIIGDNQTIATMSIHNNDVLSNLAHMMSVPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U862</accession>
    <name>A0A433U862_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Potassium channel tetramerisation-type BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_002192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000042">
        <property type="protein sequence ID" value="RUS90005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U862"/>
    <dbReference type="STRING" id="188477.A0A433U862"/>
    <dbReference type="OrthoDB" id="2414723at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008277">
        <property type="term" value="P:regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499:SF136">
        <property type="entry name" value="GH08630P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Potassium channel tetramerisation-type BTB" evidence="1">
        <location>
            <begin position="3"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS90005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="129" mass="14390" checksum="B23E8094D1CA803F" modified="2019-05-08" version="1">MVPGSVLHQIASGAQFCPRDDRGNYVIDRDGHAFRHVLNYLRTGKLIVPLGYRELDILREEAAYYGIEGLASAVDHILESRRKRARGRRWNGAARKLSASVGENLNNLAEDDEGDLDFFEDSWIGGSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U9F5</accession>
    <name>A0A433U9F5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein mS29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_001836</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000033">
        <property type="protein sequence ID" value="RUS90431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U9F5"/>
    <dbReference type="STRING" id="188477.A0A433U9F5"/>
    <dbReference type="OrthoDB" id="274828at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019368">
        <property type="entry name" value="Ribosomal_mS29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008092">
        <property type="entry name" value="Ribosomal_mS29_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10236">
        <property type="entry name" value="DAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01716">
        <property type="entry name" value="DEATHASSOCP3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS90431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="405" mass="46495" checksum="F022DFC7C472DB12" modified="2019-05-08" version="1">MAASIGQKLSSVASRTNSLLKKTVKLTEHTPCACPYYSTAAKRLEHEPRIACRTSETDPRKHTGDHVGLYYTVPEEEMAVIKTGMHPWHLRMMKSFNESCLMVRKPALELKGYLDKLNLKHPVPRFLLYGRRGSGKTLTLHHTMQCCHKDGWIIVHAPWAGQWVRGWYKEVAVSTYKPDRYDLPADSAEWLTHFRAQNLGKLSELKTTSEYIWTKREKAEVGTSFEEIINFGLSRLKFSSDCVGVLLKELRVQAETQGLKVLVVVDSVNAFYVQWNQQNALKNMEKKQLRPGEISLVHNFKKMLSPTWSHGVAICAVSEEANDEDKREDFTPIYLLGQEGFEALDPFIPIYVPDYTEKEALSNINYYIDRNWIQNDYGKTDEGKRELMFVSNRNPFNLAKICAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U9J2</accession>
    <name>A0A433U9J2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_001739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000031">
        <property type="protein sequence ID" value="RUS90471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U9J2"/>
    <dbReference type="OrthoDB" id="6157833at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS90471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="27319" checksum="E5B134D352557557" modified="2019-05-08" version="1">MLVKRVSDTVNIGHLVRREVRPVRVEARILVIGALPFTHTSLSPAPSQETGEAKSVTKLCTGELLVECSSEAQSKRLGKVETFVNIPVTVKAHRSLKYSKGVVRSRELETTNEEEMVAEFIGVTHARRIFVWKGGDQIRTNTFTFDSTSPPTSLKEGYLTLKITGTPYISRPMCPRFGNSQTRCMRTAVCGRCSKGGHAGKDCKADPSCLNCHGTHAADSKECPSGKKKRRFSGTKPGLVVLLHRPGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U9P3</accession>
    <name>A0A433U9P3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_001696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000030">
        <property type="protein sequence ID" value="RUS90519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U9P3"/>
    <dbReference type="OrthoDB" id="6434782at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS90519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="106" mass="11181" checksum="CBF139E357ABF9A4" modified="2019-05-08" version="1">MSDLPARSEIAHIPDLRGITASSEIAHIPDLRGMSDLPARSEIAHIPDLRGMSDLPASSEIAHIPDLRGMPGLPASSEIAHIPNLDGVSNNPVRRSCTGVGSVNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U9W1</accession>
    <name>A0A433U9W1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_001642</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000028">
        <property type="protein sequence ID" value="RUS90645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U9W1"/>
    <dbReference type="STRING" id="188477.A0A433U9W1"/>
    <dbReference type="OrthoDB" id="47602at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008467">
        <property type="term" value="F:[heparan sulfate]-glucosamine 3-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037359">
        <property type="entry name" value="NST/OST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605:SF65">
        <property type="entry name" value="GH20068P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605">
        <property type="entry name" value="HEPARAN SULFATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="6">
        <location>
            <begin position="74"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="active site" description="For sulfotransferase activity" evidence="3">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="295"/>
            <end position="299"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS90645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="337" mass="38382" checksum="2ACA2FF606EBC768" modified="2019-05-08" version="1">MCKKIVSVLFVLSISIYIILEVSTSLEAHNILRQHWFPEQHDTFLASLHSNDSTPPDEASSSPLLEDETQKRLPDCLIIGFSKCGTTALRGFLTLHPDIVSPLREIRYFTSHYEENLEWYKNQMPLSTAAQITVEKSAGYISTSESLERIRQMNASVKLVVMVRDPITRLQSEYARSVSKNSPRAPSFRTWCGGTAQSPSVLRLVDYATPLEQVFSLFPRQQVLVLSEELLEEKPLDILKEVYGFLGLKNTFEKTDLVFNEEKGFFCFNTSSPKYPKAKGSIVLNEKTGCLGSHKGRAHPEIGDRFFKELVDFIRPHNQRLFSLIGRKFNWPNFKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UBZ4</accession>
    <name>A0A433UBZ4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ataxin-10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_000955</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000015">
        <property type="protein sequence ID" value="RUS91243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UBZ4"/>
    <dbReference type="STRING" id="188477.A0A433UBZ4"/>
    <dbReference type="OrthoDB" id="379794at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051374">
        <property type="entry name" value="Ataxin-10/CTR86_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019156">
        <property type="entry name" value="Ataxin-10_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255:SF0">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09759">
        <property type="entry name" value="Atx10homo_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ataxin-10" evidence="4">
        <location>
            <begin position="59"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS91243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="114" mass="12717" checksum="3CF486506B527CA4" modified="2019-05-08" version="1">MLRSITEKGKSGDSVFKREEKASAQDNVDPHHPVYGLKKDLIRLIANMAYKHRGNQDLWVVLAIRNLLDGNRENRDVLSGMSLQGMAGHMSQLRAMGVHTELRGGKIVVKPADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z6D2</accession>
    <name>A0A3S0Z6D2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_020580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001179">
        <property type="protein sequence ID" value="RUS71656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z6D2"/>
    <dbReference type="STRING" id="188477.A0A3S0Z6D2"/>
    <dbReference type="OrthoDB" id="6240251at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF25">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="104"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS71656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="380" mass="44126" checksum="7F846BFEC231ACF2" modified="2019-04-10" version="1">MGDERWAEHFKEILNRPPPPEPPEIPDAGETLEVNMNPPTKAEIRKAIKTMKSGKAAGPDGIPPEALKDDINTSTDMLHPFLQKVWENEEMPMEWKKGYLVKLPKKGDLSSCGNWRGITLLSIPGKILSRIILERLRTTLDQKLRDEQAGFRQRKSCTDQIASLRIIIEQSLEWQTSLYMTFVDFQKAFDSVDREVIWKLMQYYGIPHKFINIIRRLYENSTCQVIHDGKLTDPFKVETGSVLLYGSETWGTTKTNTTKLQTFINRCLKYIFKVRWPQTISNEELWRRTEQTPIDIQIKKRKWGLIGHTLRKPPTDITRQSLEWNPQGKRKVGRPKQTWRRSMKAEIRSAGRTELKRDAQNRVRWRGVALALFSSGDPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZA33</accession>
    <name>A0A3S0ZA33_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_022053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001470">
        <property type="protein sequence ID" value="RUS70180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZA33"/>
    <dbReference type="STRING" id="188477.A0A3S0ZA33"/>
    <dbReference type="OrthoDB" id="413313at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16021">
        <property type="entry name" value="ALP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000017">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF1">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS70180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="677" mass="77178" checksum="41B1288534C474AE" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZDU2</accession>
    <name>A0A3S0ZDU2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2CD3 N-terminal C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_016873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000748">
        <property type="protein sequence ID" value="RUS75351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZDU2"/>
    <dbReference type="STRING" id="188477.A0A3S0ZDU2"/>
    <dbReference type="OrthoDB" id="6153860at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061511">
        <property type="term" value="P:centriole elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071539">
        <property type="term" value="P:protein localization to centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057537">
        <property type="entry name" value="C2_C2CD3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21254">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21254:SF1">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25339">
        <property type="entry name" value="C2_C2CD3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2CD3 N-terminal C2" evidence="1">
        <location>
            <begin position="13"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS75351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="124" mass="13603" checksum="482E0D28BAEA5A3F" modified="2019-04-10" version="1" fragment="single">GADSLTHEVKVHTGLPPQVDGQIRCFCTLSVSQVIWTVPQPPGRAYVRVKWWGETGDGVLFRPFDIKKGSKSQRNFTTAKYAVRSGPLQFATYLKDMGSLKLDVLSAPKSDVCGQAQIPKLGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZEN1</accession>
    <name>A0A3S0ZEN1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_019002</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000961">
        <property type="protein sequence ID" value="RUS73243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZEN1"/>
    <dbReference type="STRING" id="188477.A0A3S0ZEN1"/>
    <dbReference type="OrthoDB" id="2193813at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22918">
        <property type="entry name" value="HFD_TAF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08049">
        <property type="entry name" value="TAF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037818">
        <property type="entry name" value="TAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019473">
        <property type="entry name" value="TFIID_su8_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469:SF1">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10406">
        <property type="entry name" value="TAF8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00576">
        <property type="entry name" value="BTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromodomain associated" evidence="8">
        <location>
            <begin position="15"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS73243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="252" mass="27353" checksum="066ADB3CC0095B4D" modified="2019-04-10" version="1">MATDHPVVGTGLTSNPWRRSLKMAVSALLMDLGYQAADCMALETLIEMTQAYITEVGRSASSFAELSGRTQVMVSDCVMALVEMGEECLNKMVHKILQVGEKKKHPAHIPEHLPAFPDPHTYIKTHCFKQPANEYQLVREKAASQKRDVEVALTRFIAKTGATHSLFRDDKSAFPLIACKPVPLPFLAGLLPADSQMPVLDESGSDGTGKQGRGSQLGLGIGAETGADASMEAETIDNPYLVPARMAKSKWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZGZ8</accession>
    <name>A0A3S0ZGZ8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_014822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000582">
        <property type="protein sequence ID" value="RUS77419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZGZ8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS77419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="99" mass="11511" checksum="2C333C9D53E961E6" modified="2019-04-10" version="1" fragment="single">IDPSSVTSRIVILVAIRHIWTQDRIYDYILYTNIYTHNRVMPSFCAVIGCANDHKSGNRFFSIHSVRAREGEATKELLERRRRLWMKAINCGKASSRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZHZ2</accession>
    <name>A0A3S0ZHZ2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tubulin polymerization-promoting protein family member 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_014086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TPPP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000529">
        <property type="protein sequence ID" value="RUS78157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZHZ2"/>
    <dbReference type="OrthoDB" id="548799at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001578">
        <property type="term" value="P:microtubule bundle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032273">
        <property type="term" value="P:positive regulation of protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008907">
        <property type="entry name" value="TPP/p25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12932">
        <property type="entry name" value="P25 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12932:SF9">
        <property type="entry name" value="TUBULIN POLYMERIZATION-PROMOTING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05517">
        <property type="entry name" value="p25-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS78157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="20156" checksum="E10531530E63917D" modified="2019-04-10" version="1">MAEVKAQCFQTFKHFVETAAAKPNLSEADLKLITDKAMNKLLKECINDAAAKAAEVSVFPKYCDKKTKKLTFDDFFGDFMLELAAVTLQTNKKLPKRPELTDPEVVSMADGLKAKIAAKHGLTSKAMAVDATTARLTDTSKYTGSHKERFDESGKGKGTAGREDLANTSGYVQGYKNEGTYEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZI17</accession>
    <name>A0A3S0ZI17_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">E2F-associated phosphoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_016920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000752">
        <property type="protein sequence ID" value="RUS75331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZI17"/>
    <dbReference type="STRING" id="188477.A0A3S0ZI17"/>
    <dbReference type="OrthoDB" id="122464at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019370">
        <property type="entry name" value="E2F-assoc_phosphoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15967">
        <property type="entry name" value="E2F-ASSOCIATED PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15967:SF0">
        <property type="entry name" value="E2F-ASSOCIATED PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10238">
        <property type="entry name" value="Eapp_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS75331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="34968" checksum="D97232027299B409" modified="2019-04-10" version="1">MSGSLYAKENGYDMFGEDDSSDNGQSSSEDEIDIILHGTPEQKRKLHHLHKKWLTKKKNDGDMGASSSSSEDDFEKEMEAELNMQVEFMEKTRDHLAIQGISIDATSSSDQHAEASKDESKDKKEKAAEEFYDEIYFDSDEEEDASTRQNAGKNSKHRIISNDDLLYDPDMDDRDQKWVDKQRLKHGSKAGGKRGKKPNSDALLDCPACMTTLCIDCQRHEIHKNQYRAMFVMNCTVDASETLECPEQPNKKKKGKKKSQQQATDTGSTSTTSTSKDLFNPVRCSECGTVVGVYDTDEVYHFFNVLASHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZK28</accession>
    <name>A0A3S0ZK28_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_011496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000375">
        <property type="protein sequence ID" value="RUS80732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZK28"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS80732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="120" mass="11791" checksum="BC8F233DFC41A1AC" modified="2019-04-10" version="1" fragment="single">MMTGTSSLIPLRSSSASSGGAARAVSPYGSAPASGIPTPSGRSGIPSSRSQTLADKQSHRTSAGSTTSTSSSKSANASSTGANATASSSSSSAPAGSKPPASAQKNSMLDKFKFFKDKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-05-03" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZL10</accession>
    <name>A0A3S0ZL10_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_012018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000404">
        <property type="protein sequence ID" value="RUS80222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZL10"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018745984" evidence="1">
        <location>
            <begin position="20"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS80222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="221" mass="23332" checksum="8E7921F74583A820" modified="2019-04-10" version="1">MILTLTVMACLWQLWVVCPSLPEYARVCPARREPPTHASFCSSLAGRDSVICYSNYDRKAWNNPEKWEATVCVHWPSDVASNIPIMVSGRVKARPDRAVWVSSYVSSACTDPTACGQAGPLDQWLHGLEEMRCVSGGVGGGGVSGGGGVGGGGGCGGGLVVEAVVMIVVLIPVAVAAGAEFIKTTSASECENLTEKFHLAPCAKSNQFQKKMEIEIAVKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZLB8</accession>
    <name>A0A3S0ZLB8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_022177</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001500">
        <property type="protein sequence ID" value="RUS70062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZLB8"/>
    <dbReference type="OrthoDB" id="6082401at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="58"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="252"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS70062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="395" mass="44432" checksum="5719ADE312B871CB" modified="2019-04-10" version="1">METHFWMTTDSVRADLQQTQANHGGNNVVFFDSGPGKLLHSLIYFLACPVMMLVAISTNLINVTVFLRAGLNDGMTITFLGLAVSDLLYNVFYCMGRLLNAVHSVFGSRPYLNTFHLSYIFAKHGRMWFNVSVLLTVYAAIQKTACIAIPLTFRSFFTRRKSAITVIAIYLAVVTYFLPFLTLDQLQPYMERGTNRTRLGYSLRNRNMAGKIQDFVTYANRIILPYVSQGIVVICVIVITFKLRSAAETRRKMTSTNNDCDTDLNDETVGSVGDEKGKKNAESGRTNNSGSGVLSLRELRVIRSVNILCAIFIAGTTPQTIIGAFNLAFPEFGDFGAYYSVYTFTQAFQQLMEITSTAVNILVYYHFNSKYRRTFEAIFKRNIEDTNSKSETQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZLF6</accession>
    <name>A0A3S0ZLF6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_010563</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000324">
        <property type="protein sequence ID" value="RUS81701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZLF6"/>
    <dbReference type="STRING" id="188477.A0A3S0ZLF6"/>
    <dbReference type="OrthoDB" id="6144264at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A2" evidence="3">
        <location>
            <begin position="120"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS81701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="357" mass="39559" checksum="1F31344A8EBA00EA" modified="2019-04-10" version="1">MRGLGDSKPSELMDNMLSLLGDHKPCFLFRQLFMQQLPDNVRASLANSTCTDYRALAQEADKLFIAAQQHHYSLTNHERFTAESDEIEETGKRQSGPTVASASAGPRDPQLFITDDNSGRCFLVDTGAQVSVIPATPFDKIAGPSGLPLHAANGTPIQTYGSRNLQLSFNNRLYLAKLIIADVKRPLLGADFFRNHNLLVDLRGQRLIEADTFLTSPCSVGKSAVTQLAPIEAHSNRFRKILQEFPSIFQPTFSSAAVKHGVQHFIPTSCPPVHAHSRRLHPDKLADAKREFLQMEEMGNRAARGLHLSTLFRKKMEAGAPAVTIVVLMTLQLQTATPSRTSMISHHNWKGKRSFPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZLG4</accession>
    <name>A0A3S0ZLG4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_011749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000388">
        <property type="protein sequence ID" value="RUS80498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZLG4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS80498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="137" mass="15338" checksum="FE91F392DFAA63FF" modified="2019-04-10" version="1" fragment="single">MPRRDDARNTTGRESSVDPFFTKKTQWEEAKSATFVEDGSPIPGGKDGRDERPKLKSRFRESEMTVEGSSYLFLYKLKRSPLLQDVSVTVVMGEVFCFVSSDLEVSSEVLRCIAGKNTLDDGAILFNGKPFGFQNPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZNW3</accession>
    <name>A0A3S0ZNW3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Integrator complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_009958</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Integrator subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000293">
        <property type="protein sequence ID" value="RUS82280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZNW3"/>
    <dbReference type="STRING" id="188477.A0A3S0ZNW3"/>
    <dbReference type="OrthoDB" id="70899at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026236">
        <property type="entry name" value="Int2_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029321">
        <property type="entry name" value="INTS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28608">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28608:SF1">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14750">
        <property type="entry name" value="INTS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02105">
        <property type="entry name" value="INTSUBUNIT2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="612"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="900"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="615"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS82280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1157" mass="128862" checksum="EA0362A95D7A511B" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZPY6</accession>
    <name>A0A3S0ZPY6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione S-transferase kappa</fullName>
            <ecNumber evidence="4">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_012190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GST superfamily. Kappa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="4"/>
    <dbReference type="EMBL" id="RQTK01000413">
        <property type="protein sequence ID" value="RUS80073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZPY6"/>
    <dbReference type="STRING" id="188477.A0A3S0ZPY6"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000096">
        <property type="entry name" value="Glutathione S-transferase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051924">
        <property type="entry name" value="GST_Kappa/NadH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014440">
        <property type="entry name" value="HCCAis_GSTk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943:SF2">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006386">
        <property type="entry name" value="HCCAis_GSTk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="6">
        <location>
            <begin position="6"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006386-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS80073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="223" mass="25090" checksum="BE19C4AEAB60D30A" modified="2019-04-10" version="1">MSRKSVELFYDVVSPYSWFAFEVLCRYQTRWNISLKLRPFLLGGVMNESGNRPPAMVPNKGTYMFKDMHRLKKYFGVPLNIPSDPPKVMFEKGSLNAQRFLTAIDASMPDKVEPVTRELWMRIWSRDEDITSPESLAQAAKKAGVSDKDIASLLAAMKDDKIKRKLKQTTSDAMAIGAFGSPIIATEVNGEKEFVFGSDRFPVLADMIGERWEGPEPGVSSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZQ28</accession>
    <name>A0A3S0ZQ28_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">PRKR-like endoplasmic reticulum kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">EGW08_012061</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">EC2010</strain>
            <tissue evidence="19">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="RQTK01000407">
        <property type="protein sequence ID" value="RUS80172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZQ28"/>
    <dbReference type="STRING" id="188477.A0A3S0ZQ28"/>
    <dbReference type="OrthoDB" id="341578at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000251">
        <property type="entry name" value="eukaryotic translation initiation factor 2-alpha kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_b-propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF91">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="11" id="KW-0346">Stress response</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="13" id="KW-0834">Unfolded protein response</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="589"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="244"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="429"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="553"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="756"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="555"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="566"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="762"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="618"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RUS80172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1130" mass="125659" checksum="8DE5CB88BA09940B" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZT40</accession>
    <name>A0A3S0ZT40_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Phosphate carrier protein, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_010109</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000301">
        <property type="protein sequence ID" value="RUS82135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZT40"/>
    <dbReference type="STRING" id="188477.A0A3S0ZT40"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000005">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="91"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="188"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="289"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS82135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="43318" checksum="910186CA01B907CE" modified="2019-04-10" version="1" fragment="single">FRATRSSHVDYHNENETSVFFLSTSRSSEGHWCHRSKPAAMSNSIVSAYRSNVFSNPFFMNAKCESKASPIRTIAAAAPKEEYSCEFGSKKFYALCGFGGLLSCGLTHTAVVPLDMVKCRIQVDAAKYGGIVQGFKVTIAEEGVRALGKGWAPTFFGYSMQGVCKFGFYEIFKILYSDILGEENTYLWRTSLYLAASASAEFFADIALCPMEAIKVRIQTQPGWSTTLREGFPRIMKEEGVSGFYKGLVPLWARQIPYTMMKFACFERTVEILYKYVVPKPRADCTKPEQLIVTFAAGYIAGVFCAIVSHPADTIVSKLNQAKGSNFMDVAKSLGLMGMWKGLFPRIIMIGTLTALQWFIYDSVKVAFRLPRPPPPEMPESLKKKLGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZTE4</accession>
    <name>A0A3S0ZTE4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_009878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000289">
        <property type="protein sequence ID" value="RUS82363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZTE4"/>
    <dbReference type="STRING" id="188477.A0A3S0ZTE4"/>
    <dbReference type="OrthoDB" id="10071118at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS82363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="255" mass="26550" checksum="24C8B6AB5B87918D" modified="2019-04-10" version="1" fragment="single">ALDLTKLPCLALGLTKLTCLALGLTKLTYLALGLTQLTCLALGLTKLTCLALGLREKLTYLALRLTKPHARIGFGLTKLTCLALGLTKLTCLALGLTKLTCLALGLTKLTCLALGLTELTCLALGLTKLTCLALCLREKLTYLALRLTKPTCIALGSTAKLLCLGFGLTKLPCLALGLTKLTCLALGLTKLTCLALGLTKPTCLALGLTAKLLCLGFGLTKLPCLALGLTKLTCLALGLTKLKCLALGLTKLPCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZUS7</accession>
    <name>A0A3S0ZUS7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_005863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000141">
        <property type="protein sequence ID" value="RUS86345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZUS7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS86345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="208" mass="22332" checksum="3BE5D0F275A90CC6" modified="2019-04-10" version="1">MYGANDQAAACHQLGARTIISLEHSAQTFDATAYLTSVKEETKLPCPETTLATNLFNSLTDTYTGDSTTSGNSITTDNPAAMTTGKLNALGQTNVWQDLATNNWTTTTTREIIPVETNNEVPVCVFAGSNLTVASPGFKEMMENITEYIRVESQNTSMSRRKKVSAQDNRVSSVSVGVLGCCLLSVSLGMIVLTDLGRLVMFRGGAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZV66</accession>
    <name>A0A3S0ZV66_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_004704</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000108">
        <property type="protein sequence ID" value="RUS87528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZV66"/>
    <dbReference type="STRING" id="188477.A0A3S0ZV66"/>
    <dbReference type="OrthoDB" id="10258882at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019452">
        <property type="entry name" value="VPS39/TGF_beta_rcpt-assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019453">
        <property type="entry name" value="VPS39/TGFA1_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF27">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10366">
        <property type="entry name" value="Vps39_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10367">
        <property type="entry name" value="zf-Vps39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="5">
        <location>
            <begin position="536"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS87528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="835" mass="94840" checksum="A8D5E196A8CE1CBD" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZVD0</accession>
    <name>A0A3S0ZVD0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carbohydrate-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_004578</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000104">
        <property type="protein sequence ID" value="RUS87655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZVD0"/>
    <dbReference type="STRING" id="188477.A0A3S0ZVD0"/>
    <dbReference type="OrthoDB" id="59288at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09620">
        <property type="entry name" value="CBM9_like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35532:SF5">
        <property type="entry name" value="CARBOHYDRATE-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35532">
        <property type="entry name" value="SIMILAR TO POLYHYDROXYALKANOATE DEPOLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS87655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="40108" checksum="BF2C4B1E2C91A2E2" modified="2019-04-10" version="1" fragment="single">RHLLENDVEACRAVTCDIPYPRTYVIYKLRGNDVIDLDGRLEDKAWKDVAWSDSFIDIQGRDFPEPRLKTKVKMRYDYRFLYIGALLEEPDVWANVTLHDGPGAWPLWIFYKEITINARGIVADLMMTKPYVDSGEPLQFWESDLVSEVYVQGSLNNPRNEYWTIEMAVPFSTLYQGSGASMNRSSPIHDETWRANFLRCAKIKRMKRFLLFQSKISANWWVWQSPQVTNVHLPDRWGLIQFQDAKINSSRFMTSEKWVATNALLDTYSALQAFHAVTGRYTDRKELLHLPPYVFSGKCVDDVNIKLDWSGFHVTVKPKGGNLEEGHIKADHFLWFGKEDMQYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZZC1</accession>
    <name>A0A3S0ZZC1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UPAR/Ly6 domain-containing protein qvr</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Protein quiver</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Protein sleepless</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EGW08_002411</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">EC2010</strain>
            <tissue evidence="16">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Bifunctional regulator of neuronal activity in the mushroom body, and possibly other regions of the brain, that acts as a signaling molecule required for homeostatic regulation of sleep under normal conditions and after sleep deprivation. Reduces neuronal excitability by enhancing Sh/shaker K(+) channel activity; possibly by stabilizing Sh/shaker to increase protein levels, accelerating its activation kinetics, slowing C-type inactivation and enhancing recovery from inactivation. Specifically affects the A-type K(+) current. Antagonizes nicotinic acetylcholine receptors (nAChRs) to reduce synaptic transmission, possibly by preventing their localization to the cell surface. Required for regulation of neuromuscular excitability and plasticity at neuromuscular junctions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts (via loop 2 of the three-fingered Ly-6 domain) with Sh/shaker; this interaction may stabilize both components of the complex and may be required for targeting or retention of Sh/shaker to neural cell projections. Interacts (via loop 2 of the three-fingered Ly-6 domain) with nAChRalpha3 and potentially other nicotinic acetylcholine receptors; this interaction is required for antagonism of nicotinic acetylcholine receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
            <orientation evidence="1">Extracellular side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Membrane raft</location>
            <topology evidence="9">Lipid-anchor</topology>
            <topology evidence="9">GPI-anchor</topology>
            <orientation evidence="9">Extracellular side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the quiver family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000047">
        <property type="protein sequence ID" value="RUS89799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZZC1"/>
    <dbReference type="STRING" id="188477.A0A3S0ZZC1"/>
    <dbReference type="OrthoDB" id="10046582at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032222">
        <property type="term" value="P:regulation of synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030431">
        <property type="term" value="P:sleep"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031424">
        <property type="entry name" value="QVR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050975">
        <property type="entry name" value="Sleep_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562">
        <property type="entry name" value="ATILLA, ISOFORM B-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562:SF31">
        <property type="entry name" value="PROTEIN QUIVER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17064">
        <property type="entry name" value="QVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5021302417" description="UPAR/Ly6 domain-containing protein qvr" evidence="15">
        <location>
            <begin position="26"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RUS89799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="147" mass="16327" checksum="06A47182B74886A3" modified="2019-04-10" version="1">MASYQTFVGWSLTILMVCLVGSGMAIQCYQCDSNEDETCPSGRPFDTSVNAMLNCNGFEADVPGQFCVKIYQESPGWGGWQKTTRRCGSRTSFGVAWGCRWSWDYTGVFRETCYCEDKDGCNSSSQMVPGLVFLLFSCLLCMVLSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A0F8</accession>
    <name>A0A3S1A0F8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAP30-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_004710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000108">
        <property type="protein sequence ID" value="RUS87534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A0F8"/>
    <dbReference type="STRING" id="188477.A0A3S1A0F8"/>
    <dbReference type="OrthoDB" id="1714508at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012479">
        <property type="entry name" value="SAP30BP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13464:SF0">
        <property type="entry name" value="SAP30-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13464">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR PROTEIN HCNGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07818">
        <property type="entry name" value="HCNGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS87534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="48225" checksum="1B545BAF0A68967E" modified="2019-04-10" version="1" fragment="single">CLHSTTRLAVFAQEFLFIRFDFHKETEENVLMEPSGNMLRHNSGSIISSLQNYGDSDEEEVDSKNTSLKEPFSALTDEVTSQPKPSVSPASDPADTGITFSTDAGNPTTGETDASPDSKVTGSEAEVRSAEQKQESEDEKAVPEVSPAELISDDESDPSHVHRKTHKNDMKEAVAEALKDGPHTDSPSSQGSTTKPGRQTARLVSYGPDEDVDEDETSSEEEEMEEDQDASNSPEGPSDNSVLSRSVRHMSSDEIQIPPEPPGKCSESLQKKIEDSLRRKNYDLNRIIQSKKHFRNPSIYEKLIDFCHIDEKGTNFPPELYDPHIWGKESFHDELDKAQRKDMERREKEKKEKTKIEFLTGTKKSGSEHMGLGQPDEKRRKTKWDAQPTMKSIHVSNLPSAQQNPGVVNLTATATGTKATIISAVGSLSKKPGTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A1A2</accession>
    <name>A0A3S1A1A2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcriptional repressor p66 coiled-coil MBD2-interaction domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_004164</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000093">
        <property type="protein sequence ID" value="RUS88111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A1A2"/>
    <dbReference type="STRING" id="188477.A0A3S1A1A2"/>
    <dbReference type="OrthoDB" id="7331812at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016581">
        <property type="term" value="C:NuRD complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040386">
        <property type="entry name" value="P66"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032346">
        <property type="entry name" value="P66_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13455:SF7">
        <property type="entry name" value="SIMJANG, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13455">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR P66-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16563">
        <property type="entry name" value="P66_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcriptional repressor p66 coiled-coil MBD2-interaction" evidence="7">
        <location>
            <begin position="361"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="388"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="514"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="700"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="164"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="267"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="312"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="440"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="519"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="556"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="701"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS88111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="820" mass="90756" checksum="6F2F927B3DFF01CD" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A2D9</accession>
    <name>A0A3S1A2D9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_011325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000366">
        <property type="protein sequence ID" value="RUS80913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A2D9"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS80913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="114" mass="13031" checksum="63A80AB2B8C72AF3" modified="2019-04-10" version="1">MAHVLNVLKRRKDKLHVYVTLVYCMKSFSANSQLLVHIIYIQRSAKRYFDTILFHASLSLSLSLSLSLSLSLSLLFPFHSFIHYLFHNLLCIDRTGVGSYKNSGREVGSGRIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A2J2</accession>
    <name>A0A3S1A2J2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_011199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000359">
        <property type="protein sequence ID" value="RUS81033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A2J2"/>
    <dbReference type="STRING" id="188477.A0A3S1A2J2"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS81033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="175" mass="17971" checksum="5B8C628C4ACD3EFE" modified="2019-04-10" version="1" fragment="single">HDGMGRGCSTVYDGMGRGCSTVYDGMGRGCSTVYDGMGRGCSTVYDGMGRGCSTVYDGMGRGCSTVYDGMGRGCSTVYDGMGRGCSTVYDGMGRGCSTVYDGMVRGCSTVYDGMGRGCSTVYDGMGRGCSTVYDGMGRGCSTVYDGMGRGCSTVYDGMGRGCSTVYDGMGRGCST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A5T8</accession>
    <name>A0A3S1A5T8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_000842</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000012">
        <property type="protein sequence ID" value="RUS91412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S1A5T8"/>
    <dbReference type="OrthoDB" id="6155311at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008046">
        <property type="term" value="F:axon guidance receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000189">
        <property type="entry name" value="Neogenin isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000612">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057755">
        <property type="entry name" value="UNC5A-D-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25609">
        <property type="entry name" value="Unc5_NetrinR_N"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018569036" description="Ig-like domain-containing protein" evidence="12">
        <location>
            <begin position="22"/>
            <end position="1761"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="151"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="383"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="589"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="839"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="1065"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="678"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="916"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1148"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1665"/>
            <end position="1738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="678"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="689"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="924"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1240"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1389"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1677"/>
            <end position="1692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS91412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1761" mass="193629" checksum="9FF5222A6304B37D" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A9C1</accession>
    <name>A0A3S1A9C1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_006297</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000155">
        <property type="protein sequence ID" value="RUS85968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A9C1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS85968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="236" mass="26123" checksum="4D869F365054006A" modified="2019-04-10" version="1">MANFSHYDHHALFNPRARTASKLTDWIFYRVASLSTSPWRSARSESLTDPEAVALILFRPSSPVHLASAARKCVRIPRGDPSANPGRYTRQALVFHSPRQESYTMRQTRLARHTVPAFQGLCLGGSRSIAESYTMRQTRLARHTVPAFQGLCLGGSRSIASSQYVYADDVRVVVAVGRRVVSTSGRLEAHGPRKVGDQDFSLCAPSPWRILLQNTGDLGFVGPEKTQSWLVPSCQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AA35</accession>
    <name>A0A3S1AA35_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mutator-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_005758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000137">
        <property type="protein sequence ID" value="RUS86508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AA35"/>
    <dbReference type="OrthoDB" id="6277804at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049012">
        <property type="entry name" value="Mutator_transp_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33309:SF3">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33309">
        <property type="entry name" value="KERATIN, ULTRA HIGH-SULFUR MATRIX PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20700">
        <property type="entry name" value="Mutator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mutator-like transposase" evidence="2">
        <location>
            <begin position="121"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS86508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="665" mass="73996" checksum="36516E3ADBC39CD6" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AT93</accession>
    <name>A0A3S1AT93_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_020741</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001204">
        <property type="protein sequence ID" value="RUS71490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AT93"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS71490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="232" mass="26671" checksum="28BF1D48DADC2539" modified="2019-04-10" version="1">MDPPAGMERVDVPVDVMNILGLTSDSSTRQILFVDPNDSRNYSMVEIDDESMVFEGDEDIVRESGFGTYIYGPAKRNVKRRHEERSECSYDRKNGFTKQRRRNTMTISSELTVPFKLKRLKRCDEPERLAEDPCDARRSFVLSFPNLLSGDPKRVEMVKRMLLAVFNALEQYEIDDHVRNVIEMAIECAVKKSVSLSNKITSVKGPARSKLFRRRFDYVFGILKGSTLSLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AVE4</accession>
    <name>A0A3S1AVE4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_019012</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000963">
        <property type="protein sequence ID" value="RUS73227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AVE4"/>
    <dbReference type="STRING" id="188477.A0A3S1AVE4"/>
    <dbReference type="OrthoDB" id="435273at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="79"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS73227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="151" mass="16974" checksum="F6989CA2042A7986" modified="2019-04-10" version="1">MAQFFSESEIDGFKECFFFHARKGIIKSEGELSIVIRSLNFCVTKDEVKSYFDKYVAGDGSIDFASFLNVMHEHSQVEDKQKELKAALVAHDTKKQGFVDASELKHILTSIGEKLTSREVETLLREAGMPSSGPINISKFVETVMTPQPDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AWF0</accession>
    <name>A0A3S1AWF0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">VTT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_023157</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001842">
        <property type="protein sequence ID" value="RUS69084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AWF0"/>
    <dbReference type="STRING" id="188477.A0A3S1AWF0"/>
    <dbReference type="OrthoDB" id="3364966at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015414">
        <property type="entry name" value="TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12677">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12677:SF59">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="7">
        <location>
            <begin position="3"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS69084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="102" mass="11316" checksum="C8EE285A03A25FF6" modified="2019-04-10" version="1" fragment="single">DNAFNYLMVLRLVPIFPFFAINIACGALEVRLSTYFWATLIGMIPGTLIYTWVGTGLGFAINQGKDLNLGIIFEPQFIYPIIGLAILSIIPTLYKKIKGKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AXW3</accession>
    <name>A0A3S1AXW3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_021061</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001260">
        <property type="protein sequence ID" value="RUS71174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AXW3"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="509"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="549"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="72"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="455"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS71174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="589" mass="62382" checksum="EEB930057A382D3B" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AY86</accession>
    <name>A0A3S1AY86_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_016926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
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            <taxon>Lophotrochozoa</taxon>
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            <taxon>Heterobranchia</taxon>
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            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="RUS75305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AY86"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS75305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="120" mass="13516" checksum="6A04EA6B03BD561A" modified="2019-04-10" version="1" fragment="single">RDEYGDQGSKQSPITIDTGRQDEDAEQENDEENEEEDNMQRAVSGDERGGDEEEEEEAESEEDKKSRQTEDAEQEDGPGDEGEEKSEEKTFITELTPPRGADQSREQTKSTLVGKEEDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AZV3</accession>
    <name>A0A3S1AZV3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_020849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Lophotrochozoa</taxon>
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            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001221">
        <property type="protein sequence ID" value="RUS71394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AZV3"/>
    <dbReference type="OrthoDB" id="10673820at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018736675" evidence="1">
        <location>
            <begin position="20"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS71394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="137" mass="15447" checksum="B079E8B0AC246A87" modified="2019-04-10" version="1">MSQLTSTIFLMILPKICVMHPPSASRLPHVCSGQCKNYPEQTCGNVCGIVTVVGAVIAACDDDLYEYITGPMSYFFLQPTKYELYLRRILISWFIKEEITLLGLNQAFTLSHKVVREILTDPYESEVGGSVDPWSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B3J0</accession>
    <name>A0A3S1B3J0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_021121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001270">
        <property type="protein sequence ID" value="RUS71116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B3J0"/>
    <dbReference type="STRING" id="188477.A0A3S1B3J0"/>
    <dbReference type="OrthoDB" id="10679352at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053019">
        <property type="entry name" value="GATA_zinc_finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23353:SF23">
        <property type="entry name" value="PROTEIN HAIRLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23353">
        <property type="entry name" value="RAB-GAP/TBC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="643"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="721"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="768"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="653"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="773"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="830"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS71116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="849" mass="94217" checksum="E5CC027E5C99C811" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B4J5</accession>
    <name>A0A3S1B4J5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_012542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000434">
        <property type="protein sequence ID" value="RUS79688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B4J5"/>
    <dbReference type="OrthoDB" id="10564356at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018657903" evidence="1">
        <location>
            <begin position="17"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS79688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="125" mass="13506" checksum="1F7B07EB449EA79B" modified="2019-04-10" version="1" fragment="single">MLTVAALALLVVGACSLPAGMMTTMSMMQGGMMSSMSPPAPCCTPPQWQGVLVDLKSQYDVVSTVVYDTTKMMEGVWTTMRTTGQVVSHSLIDYKAMVMYQALWVAGQAPACKKESFNVPMFSCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B508</accession>
    <name>A0A3S1B508_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_016015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000680">
        <property type="protein sequence ID" value="RUS76208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B508"/>
    <dbReference type="STRING" id="188477.A0A3S1B508"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69349">
        <property type="entry name" value="Phage fibre proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS76208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="220" mass="23846" checksum="B0BC927F04CB9FE5" modified="2019-04-10" version="1">MVTSYFSRIKNCSLSGANFCSLIGISALSLSQRFRLSPSSSSVCGGWITLEVSEDNSTTVSQESRTAHSEDNSTTVSQESRTAHSEDNSTTVSQESRTAHSEDNSTMVSQESRTAHSEDNSTMVSQESRTAHSEDNSTTVSQESRTAHSEDNSTMVSQESRTAHSEDNSTTVSQESRTAHSEDNSTTVSQESRTAHSEDNSTTVSQESRTAHFSTPAIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B6J7</accession>
    <name>A0A3S1B6J7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_018939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000954">
        <property type="protein sequence ID" value="RUS73290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B6J7"/>
    <dbReference type="STRING" id="188477.A0A3S1B6J7"/>
    <dbReference type="OrthoDB" id="10043133at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018661018" evidence="1">
        <location>
            <begin position="17"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS73290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="239" mass="26493" checksum="EF486665522F193C" modified="2019-04-10" version="1" fragment="single">MKVVVWIITFILLSESVHIRALSRTSDESEARLARIQPEEGFLPGSKDIFLLSQSNFTNCVLRSRDPWVVIPTSGDALGVWKRLVKSLKGVAFFGTINPTQDAQLLSELNFPTQSSVESGAVVARVYPYGKANVKARQYQDISDPDDIQSFIVQSLPGDTVTSVGSDEELNEFLMNCLLNAPTKFPVVFIVDESRAVPGQFLSLSSRLGRYFSFCRVGVASAWALLRDLDTEQVLVQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B751</accession>
    <name>A0A3S1B751_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_018537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000908">
        <property type="protein sequence ID" value="RUS73705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B751"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS73705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="361" mass="37592" checksum="F019434EB7D35689" modified="2019-04-10" version="1" fragment="single">MSRAIGNLTARSRQGKIHAVNPELASQLLSDNTDNNNDNKNNNNNINNNSNRSSRNSNINNHGTETPRAAVRSDGTEVKQGANTPRAPDSNPNLNASERGVSRSTTEPPDTGRASTLGTGRKSSVKQVAFDLGPEGYSRTADLNSEGKPHPGRHDPSSQRRGGDSHDLDTEGNPQTGHHNRQRRGGDPQPRAPDGSVASMSDDEARADGGIQQAAGSGENNVSGTSDNNNNNNNSSNNAGHVPGASVNWDSDDFTPGGGEAGDGLSATELAEDDVGLSEIPESGRGTVTSSTSELGRLRSPSHKSLNAGEGRSPSHKSLNAGEGETPPPSTPVPAIESARSRPESTKRDGETGETGEPTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B7W2</accession>
    <name>A0A3S1B7W2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase/retrotransposon-derived protein RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_015062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000603">
        <property type="protein sequence ID" value="RUS77175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B7W2"/>
    <dbReference type="STRING" id="188477.A0A3S1B7W2"/>
    <dbReference type="OrthoDB" id="6080250at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF7">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="1">
        <location>
            <begin position="246"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS77175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="659" mass="76187" checksum="A70ED00024EEE059" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BA87</accession>
    <name>A0A3S1BA87_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_016471</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polycystin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000713">
        <property type="protein sequence ID" value="RUS75766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BA87"/>
    <dbReference type="STRING" id="188477.A0A3S1BA87"/>
    <dbReference type="OrthoDB" id="6155608at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050982">
        <property type="term" value="P:detection of mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013122">
        <property type="entry name" value="PKD1_2_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051223">
        <property type="entry name" value="Polycystin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046791">
        <property type="entry name" value="Polycystin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877:SF194">
        <property type="entry name" value="LOCATION OF VULVA DEFECTIVE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877">
        <property type="entry name" value="POLYCYSTIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08016">
        <property type="entry name" value="PKD_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20519">
        <property type="entry name" value="Polycystin_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Polycystin" evidence="8">
        <location>
            <begin position="3"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Polycystin cation channel PKD1/PKD2" evidence="7">
        <location>
            <begin position="125"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS75766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="344" mass="40455" checksum="DC0F3B7033676DFC" modified="2019-04-10" version="1" fragment="single">METRNFLKHWRFPVTWKTKDPYIFTPDSFTHFHRIDDLPLSGYKKVVYVENSTFSKDISVIKNSFWIDQHTRFIVVDFSVLNLNSKIASSIHIRFDFHRSAPYWHTNSFHFVYALTGNNYYYIAIVFVSFAVLSTYNGVKQLLLAYKMGPLRYLRYPDSYVEVIKMLLSAINCYAFLKKEALKTELLQELKYSYLIRGSYEFVDFFGMALFDYWFFATGGILAFLCIFQMLYMLSKIRRLTIFMSLTIKTVKLFYMPLLVGVAFTFLSSILFGSTTGQFSSFGLSYLMVNQYYVKPINIYADLTANHPYTGPWFYFVMGMTISIFMFNMFIAFLNEAYSAIQNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BAH3</accession>
    <name>A0A3S1BAH3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynein heavy chain tail domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_016261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000695">
        <property type="protein sequence ID" value="RUS75979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BAH3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS75979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="14119" checksum="DE41EA736371F019" modified="2019-04-10" version="1" fragment="single">MILMEVQRNLDAKKDIAERALANYTEFKNALETGQPIFNYTFGKEPIKNNYLIAPVPMFHNALNSSEELRQSIRSIPENLLNLVKQLSHLKTEALTAWSTRRVDTTLLHDECVRLSELCRQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BBP3</accession>
    <name>A0A3S1BBP3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_012498</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000431">
        <property type="protein sequence ID" value="RUS79725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8190486at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007099">
        <property type="term" value="P:centriole replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051299">
        <property type="term" value="P:centrosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902410">
        <property type="term" value="P:mitotic cytokinetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902017">
        <property type="term" value="P:regulation of cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038923">
        <property type="entry name" value="Centrobin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34439">
        <property type="entry name" value="CENTROBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34439:SF1">
        <property type="entry name" value="CENTROBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="315"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="394"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="568"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1355"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1489"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1606"/>
            <end position="1711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1725"/>
            <end position="1870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1909"/>
            <end position="1942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2029"/>
            <end position="2060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2116"/>
            <end position="2265"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1037"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1142"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1379"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="332"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="649"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="676"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="723"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="781"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="801"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="892"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1355"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1514"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1530"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1606"/>
            <end position="1619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1637"/>
            <end position="1658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1699"/>
            <end position="1711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1740"/>
            <end position="1749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1773"/>
            <end position="1791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1814"/>
            <end position="1829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1841"/>
            <end position="1870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2029"/>
            <end position="2042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2124"/>
            <end position="2135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2153"/>
            <end position="2174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="2179"/>
            <end position="2193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2205"/>
            <end position="2216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="2217"/>
            <end position="2226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="2253"/>
            <end position="2265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS79725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="2265" mass="247532" checksum="3091C65572FACB8F" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BBT7</accession>
    <name>A0A3S1BBT7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_012420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000426">
        <property type="protein sequence ID" value="RUS79821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BBT7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS79821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="105" mass="11324" checksum="3963EAECFFCC263A" modified="2019-04-10" version="1" fragment="single">SAIPQWTSKGGGDGTRSEKPSDTTPGLIPPTTSMFGVHPTLKTDSGRLTTGDKAAIGLGVIVAVHIAILAAFAFVRYRTNNGSFFRRTVLRRELSRAKNFENSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BFA3</accession>
    <name>A0A3S1BFA3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dynein heavy chain 3 AAA+ lid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_009839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000288">
        <property type="protein sequence ID" value="RUS82387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BFA3"/>
    <dbReference type="STRING" id="188477.A0A3S1BFA3"/>
    <dbReference type="OrthoDB" id="5593012at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46961">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 1, AXONEMAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46961:SF19">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 5, AXONEMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain 3 AAA+ lid" evidence="1">
        <location>
            <begin position="89"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS82387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="265" mass="31013" checksum="A742C7AA9EB04403" modified="2019-04-10" version="1" fragment="single">MMEMKGMYSLDKPGDFLNIVDISFMAAMIHPGGGRNDIPERLKRQFCIFNCTLPSNNSIDKIFGIIGEGYFCPSRFNANIVDLVKRLVPVTRILWQRTKVKMLPTPAKFHYIFNLRDLSRIWQGILYIEGEQCRTESVMINLWKHEVCRVIEDRFINDEDKNWFQKSIQQVVNEELSPELAGLLLPSPHFVDFMREMPDEPVDEEGGGMAAMEEEAQMPKIYEQIEDYDVLRNRLLAYQKEFNENIRGTFLDLVFFKDAMIHLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BG01</accession>
    <name>A0A3S1BG01_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_004811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000111">
        <property type="protein sequence ID" value="RUS87436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BG01"/>
    <dbReference type="STRING" id="188477.A0A3S1BG01"/>
    <dbReference type="OrthoDB" id="10070415at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF25">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="49"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS87436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="352" mass="40376" checksum="5AAD9619B16E43E7" modified="2019-04-10" version="1">MATSMHQCSELTLDAGLPGKAAGPDGIPPEALKANIQTSTEMLHPLLNKIWEQECVPEDWKKGYLVKLPKKGDLSSCNNWRGIMLLSIPGKVLTRIMLERLKTALDKKLRKEQEGFRQERSCTDQIATLRIIIEQSLEWQSPLYTVFVDFQKAFDSVDREIIWKLMHYYGIPTKFITIIQTLYEDATCQVIHDGKLTEPFNVQTGVRQGCLLSPTIFLIVIDWVMRQATKNQRTGIQWTLMRQLEDLDFADDISLLSHKLDDAQKKLCRVAEEAEKTGLQINISKTEVMRVNSKQQNPIRLHEEDIKEANKFTYLGSIVNKDGGSDEDIKCRIIKARQAFITLRQIWKSKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BJ50</accession>
    <name>A0A3S1BJ50_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_010196</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the endophilin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000307">
        <property type="protein sequence ID" value="RUS82040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BJ50"/>
    <dbReference type="STRING" id="188477.A0A3S1BJ50"/>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016191">
        <property type="term" value="P:synaptic vesicle uncoating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07592">
        <property type="entry name" value="BAR_Endophilin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11803">
        <property type="entry name" value="SH3_Endophilin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035824">
        <property type="entry name" value="Endophilin_A_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF81">
        <property type="entry name" value="ENDOPHILIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="10">
        <location>
            <begin position="72"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="379"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="301"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="301"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS82040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="50310" checksum="1342307B92E55666" modified="2019-04-10" version="1" fragment="single">CFCSATIRCKCRSRLVLCLDYHNGYYFHWLDHYQDLLFIGRNILSQLSTCYIGIMSLAGLKKQFNKANQYMSEKIGGAKGTELDDEFVEMERRIDVLGKLVDDLINKTHEFLQPNPASRAKMSTRNALSKMRGQEQKILYQQPEGTLGDYMIRHGTDLGEDSTFGGCLIEAGESFKHLAEIKYNLEDNVKQNFLDPLNQLQTKDLREVNHHRKKLSGRRLDFDCKKRKKDKGSTITEEELRVAEDKFEESKNLAENAMHNVLENEVEYISQLQAFIEAEVDYHRQALNTLQSLLDGLEQKRNEAASKPRTEHIPKRVSSFRRSESPNSYDGPSDAFDNDTGKSGSYNFNNIQAPSYHQSGFDPYDDQDPFGSYAVPDTKKKPMARALYDFIPENEGELGFQEGDYVDLVSQVDENWFEGTFNGQAGFFPINYVEVINPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BNP4</accession>
    <name>A0A3S1BNP4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7 9">Uracil-DNA glycosylase</fullName>
            <shortName evidence="7">UDG</shortName>
            <ecNumber evidence="3 7 9">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_004342</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 9">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="3 7 9"/>
    <dbReference type="EMBL" id="RQTK01000097">
        <property type="protein sequence ID" value="RUS87926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BNP4"/>
    <dbReference type="STRING" id="188477.A0A3S1BNP4"/>
    <dbReference type="OrthoDB" id="10031947at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097510">
        <property type="term" value="P:base-excision repair, AP site formation via deaminated base removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.470.10:FF:000001">
        <property type="entry name" value="Uracil-DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003588">
        <property type="entry name" value="PRK05254.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003589">
        <property type="entry name" value="PRK05254.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003591">
        <property type="entry name" value="PRK05254.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003592">
        <property type="entry name" value="PRK05254.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264:SF7">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="11">
        <location>
            <begin position="89"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS87926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="261" mass="29243" checksum="90DBFDC0849249C8" modified="2019-04-10" version="1">MSRKTSKRVAASSAGTNIQEKKQKLKKSTNSSTGSPTLKQYLTQPEWVCVLQDEFEQDYFKALEKLIEDEFSSGKVVFPSKDLIFNALNRTAPKDVKILLLGQDPYHGDGQAMGLSFSVPPGVPIPPSLRNMYKELSNDIAGFKDPGHGCLDKWADQGVLLLNATLTVRKSEPNSHSKFGWQKFTDQIIKSVSDESPGTVFMLWGNFAHKKEKLIDSKKHKILKTAHPSPLSCTKFYGCKCFSKANEALREMGRKEVDWKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-05-03" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BQC4</accession>
    <name>A0A3S1BQC4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_019952</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001087">
        <property type="protein sequence ID" value="RUS72280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BQC4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS72280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="155" mass="16797" checksum="00BE0A05BC50A31B" modified="2019-04-10" version="1" fragment="single">GLDLLADASENSVLLALDEGSVGSLDGEDGGTLGQQKERLWRARVGHDGGVLVQAPVLVLTIIAGLHVDDLIHSPATLDLRLARRLQSDEPVLVLQQQQRPVDYPHVELLLLRGRTVADPHELSRLPAVHVLAVRRPYGDRAVPVPVDLEQGVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BR43</accession>
    <name>A0A3S1BR43_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_019351</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PIERCE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001004">
        <property type="protein sequence ID" value="RUS72891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BR43"/>
    <dbReference type="OrthoDB" id="546383at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005879">
        <property type="term" value="C:axonemal microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035082">
        <property type="term" value="P:axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026507">
        <property type="entry name" value="PIRC1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20899">
        <property type="entry name" value="PIERCE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20899:SF1">
        <property type="entry name" value="PIERCER OF MICROTUBULE WALL 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14892">
        <property type="entry name" value="PIRC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="60"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS72891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="259" mass="28740" checksum="E7428EFF1D89F910" modified="2019-04-10" version="1">MSNSTNKKVTFKEEIDDQSNGEAECLFNIEEEPYITLKDPLHSCPFGVPPNTKLVNSCLNKHSEDQSKDSPSNCTRGLPDRSLEGQSPLKNAHSGLDSKGVTSGATLCPSNVDPARKSKSPVRTIYDGTSAGQRLTDKIKEMVIEEEFRRDNPKMRRQFPKYRGICGSLGNPVFTSTPVGPPEYQAKCPARRVPGYPPPKRQNPLYYTTSNDYGSSEPCFETTPIVFYPNDQSFTLSRALGGMYEDAHLTTDTDSTTLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BUM6</accession>
    <name>A0A3S1BUM6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase</fullName>
            <ecNumber evidence="11">2.4.2.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_016950</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of xylose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose = 3-O-[alpha-D-xylosyl-(1-&gt;3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56064"/>
            <dbReference type="Rhea" id="RHEA-COMP:14610"/>
            <dbReference type="Rhea" id="RHEA-COMP:14611"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57632"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:140575"/>
            <dbReference type="ChEBI" id="CHEBI:140576"/>
            <dbReference type="EC" id="2.4.2.42"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.42" evidence="11"/>
    <dbReference type="EMBL" id="RQTK01000755">
        <property type="protein sequence ID" value="RUS75284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BUM6"/>
    <dbReference type="STRING" id="188477.A0A3S1BUM6"/>
    <dbReference type="OrthoDB" id="6238971at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140563">
        <property type="term" value="F:UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016266">
        <property type="term" value="P:protein O-linked glycosylation via N-acetyl-galactosamine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051993">
        <property type="entry name" value="Glycosyltransferase_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46012">
        <property type="entry name" value="IP22168P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46012:SF2">
        <property type="entry name" value="IP22168P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS75284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="508" mass="58600" checksum="284D646F2675A273" modified="2019-04-10" version="1">MRGRSRAVRISIDKAPLGILRGQWGAVKTLQRLCLMHRRILFKLCVSVVVSVGVVLFYLVNVQEDRTRSGGRAYRKLVLGSSPDFMSSQLSHELRQKSDEEFLNKHVEAMRIHTQISATRSARDIHYSADKIQKPAPGPSQVKDNLYADYLGPPPDKVKKEPIHILGGFPRDTGEKAKNVSISSHIDSVSKDELILNRKVNHSVLNNSAKEHDFRFEKEHLDANIKRLRDHSHGNPIHLCVVVCGTRTQETITMLKSASMVTPLNVSFIFHIFAEPEIQRFFQDQFDLWPLVHRQRLSYHIYNVTFPDSSTTNAWKKLFKPCASQRLFLPNLLRSVERLIYVDTDTVFLESLENLWAMFDDFNSTQLAGLVGEAEASFAAWYNRFANHPFYGKFGLNSGVMLMDLDRLRQTSWLSDMQRLFHQYRLSLPWGDQDLINIYFAFHPDQMFLMPCKWNYRNDHCRYTSNCVSAERSGISVLHGSRRTFESGKEPLLKIIHQAFTKAREFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C265</accession>
    <name>A0A3S1C265_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_011390</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000369">
        <property type="protein sequence ID" value="RUS80871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C265"/>
    <dbReference type="STRING" id="188477.A0A3S1C265"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006181">
        <property type="entry name" value="D-amino_acid_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF11">
        <property type="entry name" value="D-ASPARTATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00677">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018630253" description="FAD dependent oxidoreductase domain-containing protein" evidence="8">
        <location>
            <begin position="19"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="9">
        <location>
            <begin position="4"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="35"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="42"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS80871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="330" mass="36869" checksum="DD20EA0A1F3AC600" modified="2019-04-10" version="1">MVLRIAVIGAGIVGLSTAVSVQARLPEAQVDVIADRFTTHTTSHGSGGLFVPYANNIPQELNDRWCSASAKHFFSVAASSDAGASGVNFVSGFELQALEEHPPPWAKFMINFREIPEQFHHLLKFYKRGYMFTTVIVEGGKYLSWLIQRFETNGGRIIKKKVDAFDELCDDYDLVFNCAGLGAGYLASDPKVQPIRGHIVRVWAPWIKYFVHCDDTHYFLPQSESAAIGGTRQLGRTDMAPEPHESDRILREMRERFPGLEGAKVLYDWVGLRPYRDPVRVEAEVVSCRGKQLKVVHNYGHGAFGISLSWGTAEYAAELAQQALRARPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1CEZ4</accession>
    <name>A0A3S1CEZ4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_001373</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000023">
        <property type="protein sequence ID" value="RUS90866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1CEZ4"/>
    <dbReference type="OrthoDB" id="10007716at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="546"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="466"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS90866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="623" mass="69387" checksum="B4EDF96D31FE4730" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1GZI7</accession>
    <name>A0A3S1GZI7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABC transporter TMD0 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_023003</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001765">
        <property type="protein sequence ID" value="RUS69237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1GZI7"/>
    <dbReference type="STRING" id="188477.A0A3S1GZI7"/>
    <dbReference type="OrthoDB" id="6140699at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter TMD0" evidence="3">
        <location>
            <begin position="7"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS69237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="145" mass="16734" checksum="FDC9A5B79F50EDD6" modified="2019-04-10" version="1" fragment="single">AIRDSSYPKLSKCFQQTTLTFAPCGWLWLTAGFHLVYLRRHTQYVKLPITWLHLARLIVALILGLASAVHLFLPLEDDKSFPASFYVSQSLWVITYLLACILMVYSRRFGVTSPCIVFLFWLLTMFTHIVPLYSVIMQKVNCKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H3Y0</accession>
    <name>A0A3S1H3Y0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_020509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001169">
        <property type="protein sequence ID" value="RUS71727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H3Y0"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS71727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="329" mass="36122" checksum="C40266FE93F4A7E9" modified="2019-04-10" version="1">MNSDTGRYKRHGSQLLRRLIFIIRSPLIGVAVSQPAIPYCVQLSVTLLLGSTLGRNLRGDFRLCGPQDAQGDSTWFYHARSVGHKVRSDDVMLVSTEGVVLGEMLSTMRDRQLRLDAPLLAAGSGAGEEQTEVAVKHSGEESGINQTGSRHRKALPLFTAEPGTQFSSTRLRVHVHRLQAARGQADGSKTPGTARPGGVTCSNRGEWWAGKYSAQVQQEETNIITDLKTPQTSCTFLNNPQKFEKKDPGARCELWETRREVVCEELKSAVTIDFTNTTDQQNKIYVKPNKQAFDNPGLIALSGGLVLQRAHAEQGNVMGWIQAARPQMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HFP5</accession>
    <name>A0A3S1HFP5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Voltage-gated hydrogen channel 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Hydrogen voltage-gated channel 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EGW08_013790</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">EC2010</strain>
            <tissue evidence="16">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000509">
        <property type="protein sequence ID" value="RUS78444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HFP5"/>
    <dbReference type="OrthoDB" id="427456at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030171">
        <property type="term" value="F:voltage-gated proton channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031846">
        <property type="entry name" value="Hvcn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46480">
        <property type="entry name" value="F20B24.22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46480:SF1">
        <property type="entry name" value="VOLTAGE-GATED HYDROGEN CHANNEL 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="144"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="15">
        <location>
            <begin position="97"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RUS78444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="233" mass="26670" checksum="274F330858F70A44" modified="2019-04-10" version="1">MKSNPVQYTIITLVIADCLIIVVELLIDMEIIVFPEKEQGNATDVHNASHPIAYNSDDFNQSFHHDQHWLVQGAHYMFTSNSSSNHTDGDHGDHHHHHTNKEKAQHILHMLSLAILSIFMVEVCLKIFVERSHLLKQKAEVFDAIVVIISFTLDVIFTFVSVSSVASDAAGLMVLLRLWRVTRIINGVVMSVKHDAKRKMAVQKKISRKLERENRKLRSKIEKLEASCNWQEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HK84</accession>
    <name>A0A3S1HK84_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_011047</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000351">
        <property type="protein sequence ID" value="RUS81182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HK84"/>
    <dbReference type="STRING" id="188477.A0A3S1HK84"/>
    <dbReference type="OrthoDB" id="6056075at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052065">
        <property type="entry name" value="Compl_asym_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906:SF43">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS81182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="135" mass="15142" checksum="7F9385199B82DD12" modified="2019-04-10" version="1" fragment="single">MRSWQLRTRSCDNPKPAFGGDSCNGINVENRTCVGACTNVADGASEAKDFMRKMHNVYPSLAEMCVLKHCSYKQLEATIRDDYKVTRYWSSIHCVKYEGACPVNGGWGDWAPWSSCSVKCGYGENVRKRLCNDPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HKV0</accession>
    <name>A0A3S1HKV0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phosphatidylinositol N-acetylglucosaminyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">GlcNAc-PI synthesis protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_010672</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.198" evidence="2"/>
    <dbReference type="EMBL" id="RQTK01000330">
        <property type="protein sequence ID" value="RUS81571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HKV0"/>
    <dbReference type="STRING" id="188477.A0A3S1HKV0"/>
    <dbReference type="OrthoDB" id="734129at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017176">
        <property type="term" value="F:phosphatidylinositol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03796">
        <property type="entry name" value="GT4_PIG-A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000026">
        <property type="entry name" value="Phosphatidylinositol N-acetylglucosaminyltransferase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039507">
        <property type="entry name" value="PIG-A/GPI3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013234">
        <property type="entry name" value="PIGA_GPI_anchor_biosynthesis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08288">
        <property type="entry name" value="PIGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIGA GPI anchor biosynthesis" evidence="8">
        <location>
            <begin position="59"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="7">
        <location>
            <begin position="212"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS81571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="474" mass="53197" checksum="490650E323950F7F" modified="2019-04-10" version="1">MEFITGCCLSKDFQDKMGCFRICMVSDFFYPNMGGVESHIYQLSSCLIERGHKVIIVTHHYKERKGVRFLANGLKVYYLPFPPFYNQCVLPTIFPTFPLLRNIFLRERIQIVHGHSAFSTLGHEAMFHARTMGLRTVFTDHSLFGFADASSILTNKVLSFSLADCTHCICVSHTCKENTVLRADMQPSLVSVIPNAVDPTVFLPDPTKRCLDTITIVVISRLVYRKGMDLLAGLIPGIAAKYPQVQFIIGGDGPKRILLEEVREQHQLLDRVHMLGSLEHSKIRDVLVQGDIMLNTSLTEAFCIAIVEAACCGLQVVSTKVGGIPEVMPPGLIYLAQPSIEGLTEQLEKAIEDRIDGRQPDPFELHNKIKSLYSWRDVARRTEAVYETVQETPLPDISTRLQRFRQCGLVSGRLFMLTAILNLIWLLVLQYIWPAQSVELAEEFTASKKKQSEGSKICSSPSTEILGQISKNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1I1B8</accession>
    <name>A0A3S1I1B8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_001949</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000036">
        <property type="protein sequence ID" value="RUS90260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1I1B8"/>
    <dbReference type="STRING" id="188477.A0A3S1I1B8"/>
    <dbReference type="OrthoDB" id="8112942at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS90260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="213" mass="24296" checksum="B8F73C30FA34E6BB" modified="2019-04-10" version="1" fragment="single">NSHRNLLCSSPIATCCIYVQLQPTMFKSNCNLLCSTHIATYYVQVQSQPTTFKSNRNLRRSSPIATYDVQVQSQPTMFKSNCNLLCSSPIATYYVQVQSQPTMFKSNRNLLISPIATYYVQVTSQPTTFKSNRNLLCSSPIATYYVQVRLQPTMFKSHHNLLRSSPIATYYVQVQSQPTMFKSHHNLLHLSPIATSMFQSTLQPTMFKSNRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1I2Y0</accession>
    <name>A0A3S1I2Y0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EGW08_001020</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">EC2010</strain>
            <tissue evidence="16">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WAL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000016">
        <property type="protein sequence ID" value="RUS91214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S1I2Y0"/>
    <dbReference type="OrthoDB" id="784962at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15545">
        <property type="entry name" value="PHD_BAZ2A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000199">
        <property type="entry name" value="Bromodomain adjacent to zinc finger domain 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45915:SF2">
        <property type="entry name" value="TOUTATIS, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45915">
        <property type="entry name" value="TRANSCRIPTION INTERMEDIARY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="15">
        <location>
            <begin position="1524"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="14">
        <location>
            <begin position="1656"/>
            <end position="1731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="57"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="103"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="205"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="296"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="494"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="619"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="739"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="885"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="948"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1006"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1150"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1252"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1577"/>
            <end position="1690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="322"/>
            <end position="338"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="550"/>
            <end position="565"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="627"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="651"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="814"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="891"/>
            <end position="906"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="948"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1006"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1027"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1150"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1279"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1307"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1392"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1577"/>
            <end position="1596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1669"/>
            <end position="1681"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RUS91214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1753" mass="186075" checksum="81B05313D2C3DB82" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5K2L0</accession>
    <name>A0A3S5K2L0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_000066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000001">
        <property type="protein sequence ID" value="RUS92213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5K2L0"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS92213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="152" mass="15812" checksum="C96B7F530BED14DE" modified="2019-04-10" version="1">MGVVVEVHGYQYGGIGGGSVCTLPKLVCVMVDVLVEDLDALKLVKSMVDVLVEGIKLVGSMVDVLVEGIKVVGSMLGVLVDGITVVGSRVDVLVDGITVVGSTVDVLVEVVEVVASTVDILVEAMQMVGVMVETIIKMVTLMVDVLVAVKQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SMI7</accession>
    <name>A0A433SMI7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_021858</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001423">
        <property type="protein sequence ID" value="RUS70382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6160822at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019077744" evidence="2">
        <location>
            <begin position="31"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="767"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="961"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1040"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="625"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="775"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="803"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="843"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="879"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="972"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1041"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1055"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS70382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1403" mass="151386" checksum="BCDD132FD41A071B" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SPG8</accession>
    <name>A0A433SPG8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_021130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001272">
        <property type="protein sequence ID" value="RUS71107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SPG8"/>
    <dbReference type="OrthoDB" id="10030815at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS71107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="23683" checksum="6D0D022B4EDE0471" modified="2019-05-08" version="1">MKMLGDLNDKVGTDNTNIEHIMGIHSTGEQNENGELFTEFCSFNDLIKQIQGIEEKRILPARYWEKNREVKKSTRKDTKKLLRGADNRGRGCRRSKKYGETLRDHQYSLEEEQTPQLPRQRQEWYMIPGQEEQRTRWVEHFMETLNRQALPDFPPPTELLDNTNPPNRAEIAKAIKSLKSGKAAGPDCIRPDIQTSTDILHPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SVN0</accession>
    <name>A0A433SVN0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_018885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000946">
        <property type="protein sequence ID" value="RUS73350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SVN0"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS73350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="103" mass="12167" checksum="C9218DC5AF29C303" modified="2019-05-08" version="1">MYYLNNVQKNVFTTFILIILLHHILLSIIKVSTDEICVWCCKGKYLISHSRMFCCRLPRPPVLYTQTALHSIPRSLTFHPDERLGDLESIMPQRSRKYDEMPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SX29</accession>
    <name>A0A433SX29_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_018369</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000892">
        <property type="protein sequence ID" value="RUS73867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SX29"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051082">
        <property type="entry name" value="Pentapeptide-BTB/POZ_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14136">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14136:SF17">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS73867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="252" mass="26282" checksum="EBD655036DB17CB5" modified="2019-05-08" version="1" fragment="single">DLGSIDLGSIDLSSIDMGSIDLSSVDLSSIDLSSVDLGSIDLGSIDLSSIDMGSIDLSSVDLSSIDLSSIHLRIIDLSSIHLKSIDLSSIDLGSIDLSSIHLRSIDLSSVDLGSIDLGSIDLSSIDMGSIDLSRVDLSSIDLSSIHLGIIDLSSIHLKSTDLSSMDIGSIDLSSIHLRSIDLSTVDLGSIDLSSIDLGRIDLGSIGLSSINLSSIHLRSIDLSSIHLKSIDLGSIYLSSIDLGSIDLSSIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SYX6</accession>
    <name>A0A433SYX6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_017752</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000827">
        <property type="protein sequence ID" value="RUS74477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SYX6"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="9"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS74477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="105" mass="10423" checksum="B13ABD326ADCC7AA" modified="2019-05-08" version="1" fragment="single">VVSLRIASVLTTVSTTVLATVLASALTNVLATVLASALTNVLTTVLTTVLASVLTTVLASVLTTVLATVLTTVLTTVLASVLTTVLASVLTSVLTTVLASVLTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SZX3</accession>
    <name>A0A433SZX3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_017400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000794">
        <property type="protein sequence ID" value="RUS74843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SZX3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS74843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="212" mass="22464" checksum="5718D319628FB907" modified="2019-05-08" version="1" fragment="single">ASPPLPLIFPPLIPPSSNFAFPYSSSSSACISSSSTYFSSFYFPSVFHLRRLLLLLFRLRLLPLSLLPAASVLPLTPHPSPTSLVHPDPVHFPPYPSPSATALSIVPLPAPGFHLPPTVPPAALFPLLAPRPGSFPLPSPAAPPLAPPLTTAFPSVAPPPPSYLPLSTPLPVILVLLSLSSSSSCTSILDYFVLSLFFSLFYSSSSFSSFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T0Q2</accession>
    <name>A0A433T0Q2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_017126</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000770">
        <property type="protein sequence ID" value="RUS75119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T0Q2"/>
    <dbReference type="OrthoDB" id="10630724at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="560"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="603"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="292"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="450"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="659"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="663"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="674"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS75119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="720" mass="79150" checksum="5CA9459364B5BF8C" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T2R0</accession>
    <name>A0A433T2R0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mitogen-activated protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_016427</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="3"/>
    <dbReference type="EMBL" id="RQTK01000710">
        <property type="protein sequence ID" value="RUS75800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T2R0"/>
    <dbReference type="STRING" id="188477.A0A433T2R0"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000684">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008352">
        <property type="entry name" value="MAPK_HOG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01773">
        <property type="entry name" value="P38MAPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS75800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="220" mass="25539" checksum="0D4C9A02F68C4488" modified="2019-05-08" version="1" fragment="single">YLHSADIIHRDLKPNNIGVNQNVELKILDFGLARCHSEEMTGYVVCRWYRAPEIILNWMHYNQKVDIWSVGCIFGEMITRKPLFKGADHIDQLNKILNLVGKPSEEFIQKIASKDAQTYIRKLPKTKKQDYRKYFAGANEQAIDLLERMLDLDPDSRITIDGALQHPYIVQYHDPEDEPTAAHFDSSFEGQNLNMDGWRKLVYDTVVNFKPKNVQKETGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T318</accession>
    <name>A0A433T318_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_016285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000697">
        <property type="protein sequence ID" value="RUS75958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T318"/>
    <dbReference type="OrthoDB" id="6197438at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS75958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="114" mass="11994" checksum="0FDB6A2EADB3C6EB" modified="2019-05-08" version="1">MHQSLLYKLVLCWGRASTIFAHCSVANPVRSTNSTSIMKAVVAVLCLALMVIAASAQEVSPLVQGCSMMCGQACDVGNYLATKSVPFLGDILTTLDTLCDQVCGLVCGLFAMAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T336</accession>
    <name>A0A433T336_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="9">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_016278</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="9"/>
    <dbReference type="EMBL" id="RQTK01000696">
        <property type="protein sequence ID" value="RUS75971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T336"/>
    <dbReference type="STRING" id="188477.A0A433T336"/>
    <dbReference type="OrthoDB" id="2019940at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF54">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="76"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS75971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="462" mass="54054" checksum="67F2576A73F3448A" modified="2019-05-08" version="1">MRITARFVATLAALSVLLPFLAMVLWSNGKSQTMPRTVQKMEVAPSTIDRRENNLAKQWYEDQRTFHADIFRPVPVEPAKPQSQSQPDKPLGVGIPRPLPRKPLLPAPRDPPKTLHRENPLPINREPPKPIIKENSKPINREPPKPVAVENSLRAKPEPAAVKVDKTPPRDSGKRAPPVKVSSQWWKQHLRQACRDLKMANTGQRLTKEMLSKVLVDDKNKLVFCQIPKVASTTWRRIFLQLTGKVNVPDFMAISANDVHHKYDSHLTYLSEFSDAEIQHRLRTYFKFMFVREPFERVLSAYRNKFAASTRSSEYFKWKFGRKIIDKYRKPWLIPTNNTGENVTFEEFVTYLVDDRRRVIMNEHWELFHKLCHPCIIDYDFVGHLERIDDDSQFILDSNNLSDRIKVPSRIDSKYSLRDTNSYMQEYYSELPPYAVAQIYRMYQADFILFNYTVPEEIKPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T3C5</accession>
    <name>A0A433T3C5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aminopeptidase P N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_016204</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000692">
        <property type="protein sequence ID" value="RUS76026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T3C5"/>
    <dbReference type="STRING" id="188477.A0A433T3C5"/>
    <dbReference type="OrthoDB" id="9995434at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000009">
        <property type="entry name" value="xaa-Pro aminopeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000003">
        <property type="entry name" value="Xaa-pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF6">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase N-terminal" evidence="5">
        <location>
            <begin position="100"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="4">
        <location>
            <begin position="418"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="6">
        <location>
            <begin position="648"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS76026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="743" mass="81847" checksum="55B1B19C8D0985C4" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T737</accession>
    <name>A0A433T737_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_014877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000586">
        <property type="protein sequence ID" value="RUS77363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T737"/>
    <dbReference type="OrthoDB" id="6163200at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS77363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="678" mass="78123" checksum="3CC4F769DC5FD4C3" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T755</accession>
    <name>A0A433T755_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_014860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000585">
        <property type="protein sequence ID" value="RUS77380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T755"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS77380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="255" mass="27685" checksum="DFCEE1A3A6F031A6" modified="2019-05-08" version="1">MKYSHTVHPKSSRRTEASAEVCPPATQTSPTALDGRAEVEVRRVPAGQGPDEVPAAQQVLQADLGHVLAQLHEVGQVGQLVLIGQQHQGPQRQQQQGTDQSEREGHQHQHGQPQARVDGQEDPRVVTLVAAGGRGRHAHRGTGHSGNWTGHFRHWSLWPLNRSLWPLVGLVTLATWQVTFLVTLATEQVKLVTGGTGHSRHGTGHSGHLAGHSLHWTSHSGHWCSRPGLVNFVGFLCQVSSMYALGGEIEKASYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T7A3</accession>
    <name>A0A433T7A3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_014777</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000578">
        <property type="protein sequence ID" value="RUS77471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T7A3"/>
    <dbReference type="STRING" id="188477.A0A433T7A3"/>
    <dbReference type="OrthoDB" id="7305308at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000064">
        <property type="entry name" value="GNAT family acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051016">
        <property type="entry name" value="Diverse_Substrate_AcTransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545">
        <property type="entry name" value="DIAMINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545:SF29">
        <property type="entry name" value="GH14572P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="12"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS77471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="170" mass="19697" checksum="75044ED371CC525A" modified="2019-05-08" version="1">MSFEMPSSEESFVIRKADARDSCQIYSYVQAMAKFHKANLGPNQSPENFRKGSMCQVLVVTTEADRSTILGYMLFHRAYSTWMGPVLYLEDLYISAKHRRKGLGRRLFQSVLQIGRDEKCKGMRMTVHTWNKQAKNLWEGLGCENLTETRHEHFYYYRIHDAGVTAKSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T7G4</accession>
    <name>A0A433T7G4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="1">PPIase</shortName>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_014764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="RQTK01000578">
        <property type="protein sequence ID" value="RUS77458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T7G4"/>
    <dbReference type="STRING" id="188477.A0A433T7G4"/>
    <dbReference type="OrthoDB" id="408413at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS77458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="110" mass="12472" checksum="B8C90AF5E8774944" modified="2019-05-08" version="1">MYGDTFNDENFEVGISEKGTVAMANKGPNSNGSQFFVTFRSWQFLDNMHVGFGQVVGKESLAFLDKLAEIEVDNDGLTPKKRIKIVDCQAKEVKKYKIQRRASVDQDKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TCJ7</accession>
    <name>A0A433TCJ7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin-like fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_012923</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000459">
        <property type="protein sequence ID" value="RUS79305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TCJ7"/>
    <dbReference type="STRING" id="188477.A0A433TCJ7"/>
    <dbReference type="OrthoDB" id="40334at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02970">
        <property type="entry name" value="PRX_like2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032801">
        <property type="entry name" value="PXL2A/B/C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630:SF3">
        <property type="entry name" value="PEROXIREDOXIN-LIKE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13911">
        <property type="entry name" value="AhpC-TSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS79305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="30046" checksum="E5135B9C8F3161F2" modified="2019-05-08" version="1">MATTVMNPTTTGNFTVPEQLTADISPQNITNNGAVKQITEDPFATEASRENTTGVCSPNMSRGERPEADINWPKLETLYVYDEMGNKIKFSDVYRRQKTLIIFVRHFLDFITKEYCEDISIIPLEYLQNAEVRLVVIGPAPHRFIKPFRQLTGLNHTLYVDPDREVYKALGCTEKLVSGSLETSKHIKSGFLSGVMSSVWRAMRSTDRKEFQGDIKQQGGSFIMGPGDVCHFSHIDQGSADHCQLNDLLSAAGVVNVSFPRDPRVQQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TEA8</accession>
    <name>A0A433TEA8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DJ-1/PfpI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_012330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C56 family. HSP31-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000422">
        <property type="protein sequence ID" value="RUS79892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TEA8"/>
    <dbReference type="STRING" id="188477.A0A433TEA8"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03141">
        <property type="entry name" value="GATase1_Hsp31_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF11">
        <property type="entry name" value="GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="4">
        <location>
            <begin position="91"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS79892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="240" mass="26062" checksum="54D5A47D7D0DB2D4" modified="2019-05-08" version="1">MLKIMGRRILIVLTSQGTLGDSLKKTGWYLPELAHPLKAFFDAGFTDSIDIVSPKGGAAPVDPQSAEVFKDDPTCQWLYNNEHAQKLINHTKRACDITSSNYCAVIYPGGHGPMFDLACDKEIAQVASDIFKDGGLVAACCHGPAGLVPVKDGDGNSIVRDRKVTCFTNSEEKEIEMTSLVPFALETKLKELGCNFCCAEDFQEHVVVDNRLITGQNSQSSKAFSDAVLQHLKEAHGANT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TFF7</accession>
    <name>A0A433TFF7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_011932</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000400">
        <property type="protein sequence ID" value="RUS80294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TFF7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS80294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="205" mass="23386" checksum="B8DD6143BB406E8E" modified="2019-05-08" version="1">MSEAKPTQLNLTSLSASLQLHLVKQMDIKLTPDIPGPDSGARVEWTTGHNDSYWKPHQEDGEIITRGLGRLGLGLVRGEFEDRVVGRLRLRLRFGRLGLGLVRDEFEDRVVGRLRLRLRLGLVRGEFEDRVAGRLRLGLGRGEFEDRVVGRLRLWLGRLRLGLGREEFEDRVIGRLRLWLGRLRLGLGRGEFEDRVVGRLRLGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TKM1</accession>
    <name>A0A433TKM1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_010081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000300">
        <property type="protein sequence ID" value="RUS82147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TKM1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS82147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="129" mass="15039" checksum="EFC5DB1A95082754" modified="2019-05-08" version="1">MLHNSTEKKHIKLLIAEANIHRTKDLVISTGKKDIFLSKEILSSLQMHTLSIYIHERINHNFLSTPLNLSLPGNIFVIQIIQWTCFYNKQMNVPFNVTGKNATARQLYFRKTIEKLFSIKGERLKVLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TLG7</accession>
    <name>A0A433TLG7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Lipase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_009793</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000286">
        <property type="protein sequence ID" value="RUS82447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TLG7"/>
    <dbReference type="STRING" id="188477.A0A433TLG7"/>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000012">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025483">
        <property type="entry name" value="Lipase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000862">
        <property type="entry name" value="Steryl_ester_lip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019389282" description="Lipase" evidence="4">
        <location>
            <begin position="22"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="5">
        <location>
            <begin position="60"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000862-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS82447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="421" mass="47884" checksum="B2D94BF194EC67D5" modified="2019-05-08" version="1">MMFLTGLAAVVVALLLFYVDGFSSLPTSTLEDILKFYRELDFRPGTYNLLRGNPEVNMNTAQLIRSKGYPVEFHNVVTEDGYILGVYRIPYGRNNKDSYKNGTRPVVLLQHGLFGDCDNFLLNPANESLAFILADAGADVWMGNTRGSAASRRHTTLDPKKIQFWKYSWDEMAQYDLPATIYHILNQTHHDQIYYVGHSQGTAIGFARFGEDQALASRIKHFMALAPIGRIAYAQTPIRYMLPFTSEIEFFMDTFGHGELNVPQPILKFFAAGLCEKWGEPLCESLIFLFCGFNEQSFNKSRIDVYVSHGMEGDSAQNLLHWAQTMRDKQFQRFDYGEKGNLAKYGQKTPPIYDPSKVKVPVAIFRGGQDLFADETDVDWLLKQLNVTHDTYIPFYEHLDPVIGFDAATLMYRDIVDIVMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TQF1</accession>
    <name>A0A433TQF1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine/threonine-protein kinase ATR-like N-HEAT region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_008383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000227">
        <property type="protein sequence ID" value="RUS83842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TQF1"/>
    <dbReference type="OrthoDB" id="6082889at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056803">
        <property type="entry name" value="ATR-like_N-HEAT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25032">
        <property type="entry name" value="N-HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine-protein kinase ATR-like N-HEAT region" evidence="1">
        <location>
            <begin position="36"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS83842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="221" mass="25199" checksum="2CB3BC624DFE49F3" modified="2019-05-08" version="1" fragment="single">MPNVEQPTILFLERWNSSDGPKEFSIHDYRTTIADLTDNFLTDLDEVAHSLSSNGDASGSLRSLTMCEEFLREHPDIFFETSQLSQNGETQVEETTSNAFCYWFLRHLLRILSRPDCSAVHPVIIKLVLHILNPTKMNNKFVFRQRALEIIKTLLELIAASDRLLECDSEVSISCFDFNIEMAQHSLKQAAQQSQNVSVCESKMKKVDILLSDSTHCETLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TTU7</accession>
    <name>A0A433TTU7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_007224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000186">
        <property type="protein sequence ID" value="RUS84979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TTU7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS84979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="294" mass="30545" checksum="1EB47C1EDA316FA4" modified="2019-05-08" version="1">METTQNYNCQNDSGSGGDDDDGGECGRDDVGDNGDDDDGYDVGDDGGGDSGGDDGNDSGGDDVVDSGGDSEYNGVCDIGDRNCGDGNSRNGNGRYGNGRGGNDRDNNGGDGYCSDGSGGDCKFGDDDIGNGNGCYGNAGDRNGGDGNSGDGNGGGGNDRDRNFGDGKVGDGNGCDGNDDNVHVPRVDIDVQCHRRVVHCGDDQLSVRPLSVQVELDNAWPGAHIQAWPSHCSIQKRVVEGKVEGKLGRGRKRQSWLANIQETSQLRLSVACEAALDRGRWRRMTAHLGDGTAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TTZ8</accession>
    <name>A0A433TTZ8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_007218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000185">
        <property type="protein sequence ID" value="RUS85034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TTZ8"/>
    <dbReference type="STRING" id="188477.A0A433TTZ8"/>
    <dbReference type="OrthoDB" id="5979509at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017330">
        <property type="entry name" value="SPAG7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13498">
        <property type="entry name" value="SPERM ASSOCIATED ANTIGEN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13498:SF3">
        <property type="entry name" value="SPERM-ASSOCIATED ANTIGEN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS85034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="129" mass="13845" checksum="A6632C9F95ABF0A2" modified="2019-05-08" version="1" fragment="single">FFLFAKEAEERLAKGDKHGAGITPAYNYRDKYKHLIGDEAAKDGAREMQSNTSYGFVPSSHKRDQRTIEQVLADTRAKKRQKLDDSADCSATAASSSDGTDVPQEAILSQLKTDGSVAGSQSESGAGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TVF8</accession>
    <name>A0A433TVF8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_006654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000165">
        <property type="protein sequence ID" value="RUS85571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TVF8"/>
    <dbReference type="STRING" id="188477.A0A433TVF8"/>
    <dbReference type="OrthoDB" id="9982103at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037394">
        <property type="entry name" value="TBATA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33772:SF1">
        <property type="entry name" value="PROTEIN TBATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33772">
        <property type="entry name" value="THYMUS, BRAIN AND TESTES-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15256">
        <property type="entry name" value="SPATIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS85571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="249" mass="27592" checksum="DF32E4BA09EDA7A7" modified="2019-05-08" version="1" fragment="single">VPVTEAWRDELKSFTRALGLDDAEQQKPVNGIPPNDILQAPPRSPRKEEEARPRSTMYSPDTGRLIPPPSRAMSRGMSRKGSRGGQYGGAQQPWASGNLQHISTDPDVENMVLVMLCQILQTEDVNAVQAWLCSAGEREKGHVMGLVKSALAGREEYYKQYPAEFIPDNGKTKLPPINPNSSSETNRLVLDNSEDTTLEQDARKWQKAWIPPKDGEGEACDTQQQRTVVEDNGKVFGICVHNLSQRGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TW84</accession>
    <name>A0A433TW84_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_006492</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000160">
        <property type="protein sequence ID" value="RUS85778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TW84"/>
    <dbReference type="STRING" id="188477.A0A433TW84"/>
    <dbReference type="OrthoDB" id="310870at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099604">
        <property type="term" value="F:ligand-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050927">
        <property type="entry name" value="TRPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057366">
        <property type="entry name" value="TRPM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041491">
        <property type="entry name" value="TRPM_SLOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800:SF12">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18139">
        <property type="entry name" value="LSDAT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25508">
        <property type="entry name" value="TRPM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TRPM SLOG" evidence="8">
        <location>
            <begin position="2"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM-like" evidence="9">
        <location>
            <begin position="339"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS85778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="556" mass="62297" checksum="3489EE5E2E9EFB4D" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TWF5</accession>
    <name>A0A433TWF5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRK SH3-binding GNRP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_006316</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000156">
        <property type="protein sequence ID" value="RUS85913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TWF5"/>
    <dbReference type="STRING" id="188477.A0A433TWF5"/>
    <dbReference type="OrthoDB" id="25179at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.840.10:FF:000009">
        <property type="entry name" value="rap guanine nucleotide exchange factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF224">
        <property type="entry name" value="RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="6">
        <location>
            <begin position="106"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="5">
        <location>
            <begin position="276"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="239"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="498"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="503"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00083313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS85913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="526" mass="58272" checksum="350AE604ADCD4D5A" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TYA4</accession>
    <name>A0A433TYA4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_005655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000134">
        <property type="protein sequence ID" value="RUS86574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TYA4"/>
    <dbReference type="STRING" id="188477.A0A433TYA4"/>
    <dbReference type="OrthoDB" id="6161578at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF111">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="1">
        <location>
            <begin position="53"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS86574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="116" mass="13297" checksum="35187C58563CF3A3" modified="2019-05-08" version="1">MQCGKPGDVHQRAQGNYRINQCRGQAKEGHECIKCGRIKRTRQHIPHAKRTPAAVDKRNKRERRRIGGVNHAFEILRQHTPTLSHLERASKISILRQAQAYIRELSNVLAGRNCCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TYB6</accession>
    <name>A0A433TYB6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Magnesium transporter MgtE intracellular domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_005696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000135">
        <property type="protein sequence ID" value="RUS86557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TYB6"/>
    <dbReference type="STRING" id="188477.A0A433TYB6"/>
    <dbReference type="OrthoDB" id="10071023at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006668">
        <property type="entry name" value="Mg_transptr_MgtE_intracell_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03448">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158791">
        <property type="entry name" value="MgtE N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Magnesium transporter MgtE intracellular" evidence="2">
        <location>
            <begin position="47"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS86557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="242" mass="27158" checksum="174BFBDB2D44C778" modified="2019-05-08" version="1" fragment="single">DELPSEEVDTLTDELPSEEVDTLTDELPPEEDDTLIDELPSEEDDTLIDELPSEEDDTLIDELPSEEDDTLIDELPSEEDDTLIDELPSEEDDTLIDELPPEEVATLIDELPSEEDDTLTDDLQSEDNAALIDELTSRGNARVTDGLESEDTPSDDRPLKGKGSRGQRKYFKGKGPRGHRKYTKCKGLRGQRKDTKGKGLRGQRKHSKGPWGQKHQTPSEGRKGLKGPKVQKVNWSKRSKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TYS1</accession>
    <name>A0A433TYS1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_005516</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000130">
        <property type="protein sequence ID" value="RUS86726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TYS1"/>
    <dbReference type="OrthoDB" id="8963449at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS86726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="179" mass="20725" checksum="CB97DE381FFC182B" modified="2019-05-08" version="1">METDDDDDWGEDEEPGYEDLDLYLTSSYSTSLHHTPPYFTLLHHTSLYSTLLHLTPPFPTTLYLTPPYSTSLHHTLPYSTLLHLTPPYFTLLYHTLPYFTLLHQTSPYSTSLHHTPPHSTLLHLTPPHSTIPPPPRGRILMETDDDDWGEDEEPGYEDLDLYLTPSYFTILHHTSPYFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TZW6</accession>
    <name>A0A433TZW6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Digestive organ expansion factor homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_005176</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UTP25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000120">
        <property type="protein sequence ID" value="RUS87100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TZW6"/>
    <dbReference type="STRING" id="188477.A0A433TZW6"/>
    <dbReference type="OrthoDB" id="10264378at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010678">
        <property type="entry name" value="UTP25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053939">
        <property type="entry name" value="UTP25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053940">
        <property type="entry name" value="UTP25_NTPase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933">
        <property type="entry name" value="ORF PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06862">
        <property type="entry name" value="Utp25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22916">
        <property type="entry name" value="UTP25_NTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UTP25 NTP hydrolase-like" evidence="6">
        <location>
            <begin position="306"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="UTP25 C-terminal" evidence="5">
        <location>
            <begin position="583"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="143"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS87100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="766" mass="88596" checksum="C474C066D6BFD0A1" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U5F6</accession>
    <name>A0A433U5F6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="9">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_003195</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="9"/>
    <dbReference type="EMBL" id="RQTK01000068">
        <property type="protein sequence ID" value="RUS89024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U5F6"/>
    <dbReference type="OrthoDB" id="6380564at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF54">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS89024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="339" mass="40059" checksum="AA24266FEB482A09" modified="2019-05-08" version="1">MTKRLNHTKFMCEKFKVPNQVDSEIFILPPFNLTYCKIPKAGCTYWEQLFSFLNKPPTELAYLGIRSPFQISKYDIRYTSHFNLPRRDYRIEADKAEADLSTKILFVRHPLERLWSCYIEKFFLLDFWTTAGVHMKTVGAEEKCPKSITFREFVEFSLPLYNENWAPMTELCNPCLYNPTVIGHVDTMRDDTLYTLKQVKLDWIFTEHEKLSREENQMMDTVIYNYEIHSINWYSFYHKCLTQKELAGKLWDVFQKVGYLGAGAILPDNLPDYNETTVVKELKMQFKKFPLTPLAGRQQRLKNLKTDYEALPKPLMAKILERYAMDFQLFGFETAIPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U5I2</accession>
    <name>A0A433U5I2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_003154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000066">
        <property type="protein sequence ID" value="RUS89091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U5I2"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS89091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="188" mass="21484" checksum="CFBA0F21BA5DCE2B" modified="2019-05-08" version="1" fragment="single">MLVLVELERALGQGEVWKQSHEQPLQNYGGVHQPYLRDAEDYHHQHESHTLTCYNVEHGDPNVRSGRHREGERKEVHIGEHSPSVEHKQQDHVEPVQVLGERVYGEDEEDDYDYQARHHVVDQVPDQRGQPEVHRVHAAHKLDVLGLDGALPHQEQHKAASQERHAEGQVEAHGEAGRVFAKTLVVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U5Y7</accession>
    <name>A0A433U5Y7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SMB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_003034</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000062">
        <property type="protein sequence ID" value="RUS89224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U5Y7"/>
    <dbReference type="STRING" id="188477.A0A433U5Y7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036024">
        <property type="entry name" value="Somatomedin_B-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001212">
        <property type="entry name" value="Somatomedin_B_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01033">
        <property type="entry name" value="Somatomedin_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90188">
        <property type="entry name" value="Somatomedin B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50958">
        <property type="entry name" value="SMB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMB" evidence="3">
        <location>
            <begin position="434"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="371"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="753"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="378"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="762"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS89224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1002" mass="111825" checksum="CD9DCA9A7006B5FF" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U9W2</accession>
    <name>A0A433U9W2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_001597</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000028">
        <property type="protein sequence ID" value="RUS90600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U9W2"/>
    <dbReference type="STRING" id="188477.A0A433U9W2"/>
    <dbReference type="OrthoDB" id="10260946at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034709">
        <property type="term" value="C:methylosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007309">
        <property type="term" value="P:oocyte axis specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052139">
        <property type="entry name" value="Methylosome_Comp_WDR77"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46853">
        <property type="entry name" value="METHYLOSOME PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46853:SF1">
        <property type="entry name" value="METHYLOSOME PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="112"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="154"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS90600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="388" mass="42086" checksum="788AF45A6AECEE87" modified="2019-05-08" version="1">MRTATTEDMYQYEKPTAMDRQLDVLQCHADGGLLLGASSLTGQYWFGSIWFYQRPELAPGVDGCTAGVQLEAGLGDARWVDSTHVLVGLDTGGIAVWRLEDDFHTFVLSQSAPGHDGVVTSTAVASDRQRAVTAAQDRCIKIWDLSITSLIYSAKAHNSLISCVDSHPSEPDLFLSCAQDDRILLWDKRKPKPASILKKSPLEHTATCLRWQPGQAHKFAVGSESGQLAMLDIRAGVDNFRTASPHDRPVYNLQFCAEKPSLLASVGEDCRTVVTSVLEDDDMKQIYSNTSHQDFVHGLTWPSYSRLYTCGWDSQVLCHNIDACTSVALGQRSAASNTQADNGAEDAAVKSAVLTNGDISDHIGDGDSSLKATYSQAVKTAQEISAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UA49</accession>
    <name>A0A433UA49_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_001577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000027">
        <property type="protein sequence ID" value="RUS90677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UA49"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS90677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="402" mass="43796" checksum="52A96EC8E00EC67B" modified="2019-05-08" version="1">MDTRTTAWAGGGGRDLGQTSGVNGPQKTGSQHHPDDCGEPKTDQARDADTVKRMASCPPGEPCPPSPGSKVSRVCLVLLCAVQPIVRGASVGLPLTACCPGPRQYAQVWSSEPLHIGICSQAFGMRSSGAGGGTRPVLGQPQSIQVAKFVSAYWPGLGTVSQVCCFKHQNMSMSFMNQPNSVEYSPISIRQKRKVLVGGGPPPGLVTKRPVLVYLLHNYVIGPGKIWVNAVTGAKASLVYTFFQGPSTIQHHHNQWGYFPSALAGRAEGVIDPGSQGRVHALVNTVHQPGWVEWPGMLAQSKPKYFGQLDKHDSLRRHILLLEAELGAKHRPTRRWMGHISDSLQRRPSESGRIAQEKELFRQIVVLCGRLHQTPPTSQHDDDNDDDDDDDDDDDDDDDDEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UA73</accession>
    <name>A0A433UA73_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_001466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000025">
        <property type="protein sequence ID" value="RUS90755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UA73"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS90755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="208" mass="22378" checksum="2F5B0BE54514146C" modified="2019-05-08" version="1">MDAGVQENLYEDIKIVDRESSGQRKESPVQDVVNPKSRHRHQPGVVSGSGQSMGRGTFGREKSQSKNREDESSPKDDLLSPEERDMFIALGLAGERPNTDKNVTDLDNTATVEGRNSAELNIQPSATSGLKGNDHDPPETHENVKPSVKTKKTARPDLVSDILELSLQNIKGMKRGQGGDEAGGGGDGGVSEQDAVDLQEGQVQMSEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UBV5</accession>
    <name>A0A433UBV5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LolA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_000956</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000015">
        <property type="protein sequence ID" value="RUS91244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UBV5"/>
    <dbReference type="OrthoDB" id="10520688at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058831">
        <property type="entry name" value="LolA-like_dom_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36902">
        <property type="entry name" value="ENRICHED IN SURFACE-LABELED PROTEOME PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36902:SF1">
        <property type="entry name" value="ENRICHED IN SURFACE-LABELED PROTEOME PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25898">
        <property type="entry name" value="LolA_2nd_metazoa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019456965" description="LolA-like domain-containing protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="606"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="LolA-like" evidence="3">
        <location>
            <begin position="266"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS91244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="651" mass="73211" checksum="F5499DCCFD39D858" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UD00</accession>
    <name>A0A433UD00_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_000617</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="RQTK01000008">
        <property type="protein sequence ID" value="RUS91644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UD00"/>
    <dbReference type="STRING" id="188477.A0A433UD00"/>
    <dbReference type="OrthoDB" id="205248at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000254">
        <property type="entry name" value="Serine/threonine-protein kinase RIO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051272">
        <property type="entry name" value="RIO-type_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017406">
        <property type="entry name" value="Ser/Thr_kinase_Rio3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45723">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038146">
        <property type="entry name" value="Ser/Thr_PK_RIO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="13">
        <location>
            <begin position="261"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="539"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="549"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="580"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="598"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS91644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="640" mass="71974" checksum="8F4BCDF69975ADC4" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UE06</accession>
    <name>A0A433UE06_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">KIND domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_000345</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000004">
        <property type="protein sequence ID" value="RUS91943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UE06"/>
    <dbReference type="STRING" id="188477.A0A433UE06"/>
    <dbReference type="OrthoDB" id="10254377at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032045">
        <property type="term" value="C:guanyl-nucleotide exchange factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048814">
        <property type="term" value="P:regulation of dendrite morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011019">
        <property type="entry name" value="KIND_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029899">
        <property type="entry name" value="KNDC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21560:SF0">
        <property type="entry name" value="KINASE NON-CATALYTIC C-LOBE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21560">
        <property type="entry name" value="VERY KIND PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00750">
        <property type="entry name" value="KIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51377">
        <property type="entry name" value="KIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="KIND" evidence="4">
        <location>
            <begin position="42"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="KIND" evidence="4">
        <location>
            <begin position="324"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="248"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="490"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="628"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="253"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="510"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="530"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS91943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="672" mass="74533" checksum="A2C0E7299B4B3EE6" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z1S5</accession>
    <name>A0A3S0Z1S5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_023371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001959">
        <property type="protein sequence ID" value="RUS68866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z1S5"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS68866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="114" mass="16404" checksum="1C7921F4C6210F02" modified="2019-04-10" version="1">MLEKNEKKKRKKRTTRRSRRRRRRRKSRSRWRDKSRSRFRPIRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRKSRSRWRDRSRSLFRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z5K1</accession>
    <name>A0A3S0Z5K1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_021054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001259">
        <property type="protein sequence ID" value="RUS71184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z5K1"/>
    <dbReference type="OrthoDB" id="6274630at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS71184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="139" mass="14830" checksum="A020C53E4ED43A0A" modified="2019-04-10" version="1">MSALRASGGIPSGPAALPDLRDLMALVISALLGAFVFMLRGSVCDGMSTGVDGAGLFSVSLKCSAHRRLWSSSPGMVFPSLSFMGRLLEFFFPESVLVISYSLFIFLWPAAVSASVVSSSMKVLLSCLALFFTCRFRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z7A6</accession>
    <name>A0A3S0Z7A6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Argininosuccinate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_021237</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001289">
        <property type="protein sequence ID" value="RUS71002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z7A6"/>
    <dbReference type="STRING" id="188477.A0A3S0Z7A6"/>
    <dbReference type="OrthoDB" id="2561043at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000001">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000002">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000014">
        <property type="entry name" value="Os03g0824900 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814:SF1">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="4">
        <location>
            <begin position="10"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Argininosuccinate lyase C-terminal" evidence="5">
        <location>
            <begin position="367"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS71002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="470" mass="52996" checksum="01C2C1D84A24F057" modified="2019-04-10" version="1">MVEGNKLWGGRFTGAVDPIMEKFNASIHYDKRMWKADIEGSMAYVKALEKANLVTADEREDIYEGLEKVRHEWEAGTFELRPGDEDIHTANERRLKEIIGATGGKLHTGRSRNDQVATDMRLWFKDAAKVLCDHISDLIRVMVTRAEQEIDVLMPGYTHLQRAQPIRWSHWVLSYAAMLQRDVERLEQIKDRANTLVLGSGALAGNPFNIDREFLRQELHFDKISSNSLDAVSDRDFVVEFLFWASLLGVHLSRWAEDLILYTSKEFGFVTLSDAYCTGSSLMPQKKNSDSLELIRGRAGRLYGNCTAFTMAMKGIPSTYNKDLQEDKEAMFDSFDTLNAILQVATGVLSTLKIHPDKMKGALSPDMLATDIAYYLVRKGLPFREAHGMAGLCVALAEKQSIPVSQLSHKDFQSVSSKFEDDVVDVWDYDNSVEQYAAQGGTAKESVRTQISSLRAWLELKCDSGVITRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZBS1</accession>
    <name>A0A3S0ZBS1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_016975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000757">
        <property type="protein sequence ID" value="RUS75260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZBS1"/>
    <dbReference type="OrthoDB" id="6022714at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031380">
        <property type="entry name" value="SIX6OS1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15676">
        <property type="entry name" value="S6OS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS75260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="360" mass="41239" checksum="C26A109C25472809" modified="2019-04-10" version="1" fragment="single">MMASTMNDQVDLDSTELDRLIHNLEYENQQCVKMIEKNDQVISSLSSQIEHKVQEKIRLEEEISKFDDDTRRLHRNFTNNRDNIACLKNTMSVMSDHMDALSKQLSTLQIKTSEESKTYNEHVTNYSKTRDEYMVKYRSFPWALNLEKAQKVVQNLQAKVKEIGEKKNKIAEQISTVEEVLSTKVMTRIVMKMAKIKVITHGLESEIHECVTQKTILLEQLKELQKSKHEQQEVAIVTEDDGSKSSKDVVDDTPSNEVEEIRMSDETDQLTCNTSVEETYKHLNEISKTKNPTHNLEKNDNLDVDGDVLMEEVGPSAQKCDQPAPFNAEELPCPQPEIIKASVKRNLPTFGDHFGKAPNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZE94</accession>
    <name>A0A3S0ZE94_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein rogdi homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_019218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the rogdi family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000985">
        <property type="protein sequence ID" value="RUS73012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZE94"/>
    <dbReference type="STRING" id="188477.A0A3S0ZE94"/>
    <dbReference type="OrthoDB" id="66510at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028241">
        <property type="entry name" value="RAVE2/Rogdi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13618">
        <property type="entry name" value="LEUCINE ZIPPER CONTAINING TRANSCRIPTION FACTOR LZF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13618:SF1">
        <property type="entry name" value="PROTEIN ROGDI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10259">
        <property type="entry name" value="Rogdi_lz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS73012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="30661" checksum="E1953C6E39F7E6C9" modified="2019-04-10" version="1">MGDVSVKEKAELDVLQKELAWLLKNEVHPVLNGVRETLQECYDCLPFHGAAEKVAEQDTQPQRILLTCPNASSINFKSVVTLTGDCVEEADLQFKHKQGKEHHLFRTKVKQGCVWRLPQIRDAGNHLCSALEIASKNDPTYEYKSVKEVFLLLDELMDSLLKSRQCLSLPKRKSIQDLLDSQQLLSFKPPLPNDVAISFYIHTSKLVLALYFLHTNSQHQRVEITHRVQVEAMVKWLNEAIIFFTLSLQQCQQLKDKLMAVSKILENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZEN0</accession>
    <name>A0A3S0ZEN0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Polysaccharide pyruvyl transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_015061</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000603">
        <property type="protein sequence ID" value="RUS77174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZEN0"/>
    <dbReference type="OrthoDB" id="6134158at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007345">
        <property type="entry name" value="Polysacch_pyruvyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04230">
        <property type="entry name" value="PS_pyruv_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="105"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Polysaccharide pyruvyl transferase" evidence="7">
        <location>
            <begin position="520"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="Polysaccharide pyruvyl transferase" evidence="7">
        <location>
            <begin position="719"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS77174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="763" mass="85305" checksum="9DB4F43725C6972F" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZGV1</accession>
    <name>A0A3S0ZGV1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_013624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000499">
        <property type="protein sequence ID" value="RUS78618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZGV1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS78618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="109" mass="12752" checksum="7756FDC9972D9C11" modified="2019-04-10" version="1">MTIMNILCFYSNLVSNFCLYCINNEQYIHAQYTILINALELICISFSLLSNDNLFSQNLSYVNILKCFMIHANQIIKYVIILCFYLHYTCSYELKVFALHANLIKTSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZGY3</accession>
    <name>A0A3S0ZGY3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_017603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000813">
        <property type="protein sequence ID" value="RUS74623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZGY3"/>
    <dbReference type="OrthoDB" id="6138003at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018692866" evidence="1">
        <location>
            <begin position="20"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS74623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="101" mass="11332" checksum="DFB15CD3B4CE49AC" modified="2019-04-10" version="1">MKVTLAFFAALLAVGMCATVQMLIHHEVVYLYSQDHDMTVDHCTTKCDALFDLIAGHDEDRTDRLCHYECLCQKNNNCHTITASPQHVHRTTTSAPAVDQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZI48</accession>
    <name>A0A3S0ZI48_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tonsoku-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EGW08_013971</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">EC2010</strain>
            <tissue evidence="17">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Tonsoku family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000521">
        <property type="protein sequence ID" value="RUS78280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S0ZI48"/>
    <dbReference type="OrthoDB" id="5806726at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052311">
        <property type="entry name" value="MMS22L-TONSL_complex_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46358">
        <property type="entry name" value="TONSOKU-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46358:SF1">
        <property type="entry name" value="TONSOKU-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 15" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="15">
        <location>
            <begin position="352"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="547"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="580"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="616"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="469"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="825"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="879"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="917"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1091"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="495"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="928"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="956"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="977"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1100"/>
            <end position="1116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RUS78280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1587" mass="176768" checksum="33856A3C14954728" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZLV1</accession>
    <name>A0A3S0ZLV1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_021837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001418">
        <property type="protein sequence ID" value="RUS70393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZLV1"/>
    <dbReference type="OrthoDB" id="10067067at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS70393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="23449" checksum="05E1247E43FF33E7" modified="2019-04-10" version="1">MLLRIQPYDCTIVYKPGPEMILADYMSRASPDEGQTIDKMFFVKNLTIITSKACIDYFKSVFAVHGIPDELITDNATVVKRSKEPRSYIVLTDRGQQLRRNRRHLRELPTPGKVGNHRSSHRQQHSGKAGSDDFTQVDTEHSIPLAQFTHSTQTPPLHNTDSTGLADLGLQTTAKEDNPSDDTHCNAEAPTTGTSSRCGRPIVRPSRFCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZMS9</accession>
    <name>A0A3S0ZMS9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 13 VPS13 adaptor binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_021168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001278">
        <property type="protein sequence ID" value="RUS71064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZMS9"/>
    <dbReference type="STRING" id="188477.A0A3S0ZMS9"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039782">
        <property type="entry name" value="VPS13B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12517:SF0">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12517">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 13B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS71064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="31583" checksum="90FD99889BD422A4" modified="2019-04-10" version="1" fragment="single">SSSSESLPSQVCRSSDSPDRPISDLEIDLEPQPSVDLQVRLSEYIPGCDTLLVEVAPTCLLHNATDMDVVLASGDDDGNLRWTIRPGQTMAPPSPKTNLRLAVKHQSVKSDEKTIPVSMETSDYRRYNDDLGRVLFLDSFVHVSFQLSQPDQGRVEMAFLSVSSDMKHGIRIICVRERFAVTNRTGLDLHSKLLALPLSLTPISMSEAIGTRVTCPGGKTSSAHRKGDEGRSAGSRKPDSMPLFRWSVVAGQGESPRPKVEGPEGEQTFVCYISLSRVVGSGATNRASQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZS10</accession>
    <name>A0A3S0ZS10_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_018347</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000889">
        <property type="protein sequence ID" value="RUS73896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZS10"/>
    <dbReference type="STRING" id="188477.A0A3S0ZS10"/>
    <dbReference type="OrthoDB" id="294696at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052643">
        <property type="entry name" value="ERP44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46295">
        <property type="entry name" value="ENDOPLASMIC RETICULUM RESIDENT PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46295:SF1">
        <property type="entry name" value="ENDOPLASMIC RETICULUM RESIDENT PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018549747" description="Thioredoxin domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="6"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS73896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="427" mass="47864" checksum="6EE6B3EFB9B68281" modified="2019-04-10" version="1">MKGDEMQLLLALILMTLVGKHNVGGEAVSLNLENADSVLKSSDIAVVNFYADWCRFSQILAPTFDEAGKKIQEEISAPGSIVFAKVDCDREGTLAARYRINKYPTLKIFRGGVMMKKEYRGQRSVDALVQFAKDEARPAIQDVDSLDQLKTFDTKKLHIIGYFDNRESDGYRSFARVASILRDDCQFHSAIGPVSASERLNGDRVNFYSPTDAASPNNQYALALNDFDSLYKWTTEKCTPLVREITFENAEELTEEGLPFVILFHHPDDTSTPSDFKNRVQQEAASEKASVNFLVADGLKFAHPLHHLGKSSKDLPILAIDSFRHMYVFPHPVKDGLNTPGLLKRFIEDLHSGKLHREFHHGPDPTPPAIEVVSSNNQGDGDSNTKNIPRDDVKSRPQAQKITSPPESTFRKLGPSRNRYTILRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZWX6</accession>
    <name>A0A3S0ZWX6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_014951</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000592">
        <property type="protein sequence ID" value="RUS77287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZWX6"/>
    <dbReference type="OrthoDB" id="6119547at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018642385" evidence="2">
        <location>
            <begin position="17"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1073"/>
            <end position="1096"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS77287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1119" mass="124642" checksum="A17C20600C0867E8" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZXB4</accession>
    <name>A0A3S0ZXB4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Aconitate hydratase, mitochondrial</fullName>
            <shortName evidence="13">Aconitase</shortName>
            <ecNumber evidence="13">4.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EGW08_003252</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">EC2010</strain>
            <tissue evidence="17">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="13"/>
    <dbReference type="EMBL" id="RQTK01000069">
        <property type="protein sequence ID" value="RUS89005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZXB4"/>
    <dbReference type="STRING" id="188477.A0A3S0ZXB4"/>
    <dbReference type="OrthoDB" id="2224430at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00718"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01584">
        <property type="entry name" value="AcnA_Mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000003">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000004">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1060.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF3">
        <property type="entry name" value="ACONITATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="9 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="15">
        <location>
            <begin position="70"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="16">
        <location>
            <begin position="587"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="528"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="549"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RUS89005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="783" mass="84808" checksum="619F199D719726B4" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A4E4</accession>
    <name>A0A3S1A4E4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DUF4203 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_001928</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
            <orientation evidence="1">Nucleoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NEMP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000035">
        <property type="protein sequence ID" value="RUS90330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A4E4"/>
    <dbReference type="STRING" id="188477.A0A3S1A4E4"/>
    <dbReference type="OrthoDB" id="509138at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019358">
        <property type="entry name" value="NEMP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13598">
        <property type="entry name" value="AT07567P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13598:SF1">
        <property type="entry name" value="AT07567P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10225">
        <property type="entry name" value="NEMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018728132" description="DUF4203 domain-containing protein" evidence="9">
        <location>
            <begin position="23"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS90330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="35623" checksum="35431B5AEF0376F4" modified="2019-04-10" version="1" fragment="single">ARYRSGSLILCCILLCGASVESLQDSLCVAPTCVNVNLTLNLMEVKVTERIDGGSKLCIFCYPGADRRWFRVWINPKMRINLPSQNFMPDIFHGSNISEVVERSRSTSYLRWPSLWGQLRQEYGFKPFNASCIGVMSDKGYTVDFVVKSKYVAITFLAALYYTYCPDVVSFRNKLFHYGTGVSVGVLGSALIALFIINKFLPQRVKTLGSVLLVVSTSASMFLLQHVSLYINDIIFDYWRVALGYVLVAGVASCALIYRYEPLSDPRTLDLARWGLQALGLALVYQGCQIPEMGVVVVAVACVVYYFPRGLLSWLRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A775</accession>
    <name>A0A3S1A775_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_007789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000206">
        <property type="protein sequence ID" value="RUS84405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A775"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34239">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34239:SF2">
        <property type="entry name" value="TRANSPOSABLE ELEMENT P TRANSPOSASE_THAP9 CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS84405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="138" mass="15105" checksum="1353E96FB4557286" modified="2019-04-10" version="1" fragment="single">SPSGSGPSRPKKALKETGGGERDTGSVSPQDCTSAPECPGLDDLDNLSVLSEGELSEEDDDNTISNLEAFYGFHDQEGDKFDDKLIQIVDAGLCKKPDEAKTKDLLEQYPKPVNSKNLRVPKTNGEVWKLLTKNQRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1ABC1</accession>
    <name>A0A3S1ABC1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_004807</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000111">
        <property type="protein sequence ID" value="RUS87432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1ABC1"/>
    <dbReference type="STRING" id="188477.A0A3S1ABC1"/>
    <dbReference type="OrthoDB" id="7676067at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032874">
        <property type="term" value="P:positive regulation of stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052125">
        <property type="entry name" value="KLHDC10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46428">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46428:SF1">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS87432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="428" mass="48113" checksum="D6BFA1E8F357A52E" modified="2019-04-10" version="1">MKVGRTIVPAAHSNRCRTSRVLSEKENASDFECSCCPIGRSGHRVVVSEDSIYSLGGFNPAVCGLPDNRPIHEPDERGLPLFQELWRFNISSRRWQMLDDFQSVPPTIASHTIAKTGRWLFCFGGTSIPFGLTATNVIYRYDLQSSNKPLVTGDIDVKEDEIALRSPDDFRWHLVPVTGDIPEERYGHSMTMSFPDIYIVGGTSGHVYNAEVFHLDLRNGVGKWTKLSSDTDPKQPSGRYRHETAFDGELLYVFGGGTDQEAFPLTDVHTFNIVRKEWGEIKTLPDPQHGHPAPRKCHSCSQYKNDVYLVGGVSGTLATNQVTCYDDIWRYSLSEGAWTKFSFTLTVPLYFHSADICEKTGAIWIFGGVTNGRNANMRTNRLIHLQVKVGSLLELTWTVICNQVCNRWDRVDMDELGIPGFLQARLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AS85</accession>
    <name>A0A3S1AS85_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_021599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001362">
        <property type="protein sequence ID" value="RUS70641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AS85"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS70641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="117" mass="13261" checksum="0077620B6FFE35B4" modified="2019-04-10" version="1">MGTKNTGNPRELNQRLRIRTQALYQRDQTRHPTKTEVCFTSWPVNHVTRAVLNRARIPGTRMVTTWITSSSSTVRSRSTTPGTSTGFHQHQVVTPHEWLVSYHGHHNAMTSSLALSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AX62</accession>
    <name>A0A3S1AX62_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UPAR/Ly6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_022648</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001628">
        <property type="protein sequence ID" value="RUS69588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AX62"/>
    <dbReference type="OrthoDB" id="6150894at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018770087" description="UPAR/Ly6 domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS69588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="17911" checksum="535D770D1EDF78AA" modified="2019-04-10" version="1" fragment="single">MMIAQVAFAVLCIAVTSAIPVPEEGAGSQLYCHVCTDAVGNNNCSNTEICDSDSSVCLTTLVYDDSAVSIEKRCARKQVCYNMEENNEDGCYNADDEFDGVCSFCCTRPGCNEFNPIFKTDDDTANMRKGGGNTGSKRTSRPKPTSHAKATSKPRSQRPNSRPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B3V9</accession>
    <name>A0A3S1B3V9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_017860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000836">
        <property type="protein sequence ID" value="RUS74379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B3V9"/>
    <dbReference type="OrthoDB" id="6084619at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS74379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="21561" checksum="649452A64B12404F" modified="2019-04-10" version="1">MNGYLRVINALEIFKRPDSVIKVMSNSTRPVDISVKAKGDACCMIDVLYYFNQTSVALTQYTLSNPPFRRNSTTGELSFDPSSIPKEDLEKWVGDYKCRVSNKHESKVFDFIIVTEESNRQPITAAEASTGLWWIYILLGVLAIAIVFVVVIVIYKSNYPGETYQLEKTELKHHLNPEEDLLNQSFQEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B432</accession>
    <name>A0A3S1B432_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="10">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_017698</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="10"/>
    <dbReference type="EMBL" id="RQTK01000821">
        <property type="protein sequence ID" value="RUS74550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B432"/>
    <dbReference type="STRING" id="188477.A0A3S1B432"/>
    <dbReference type="OrthoDB" id="59470at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:Golgi membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.310:FF:000001">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1960">
        <property type="entry name" value="QSOX sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040986">
        <property type="entry name" value="QSOX_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042568">
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    </dbReference>
    <dbReference type="InterPro" id="IPR041269">
        <property type="entry name" value="QSOX_Trx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039798">
        <property type="entry name" value="Sulfhydryl_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22897">
        <property type="entry name" value="QUIESCIN Q6-RELATED SULFHYDRYL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22897:SF8">
        <property type="entry name" value="SULFHYDRYL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18371">
        <property type="entry name" value="FAD_SOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18108">
        <property type="entry name" value="QSOX_Trx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0274">FAD</keyword>
    <keyword evidence="3 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="649"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="12">
        <location>
            <begin position="41"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="11">
        <location>
            <begin position="415"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS74550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="697" mass="80149" checksum="139E5C812D1306AA" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B4F8</accession>
    <name>A0A3S1B4F8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA helicase B winged helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_016458</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000712">
        <property type="protein sequence ID" value="RUS75772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S1B4F8"/>
    <dbReference type="OrthoDB" id="416437at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058839">
        <property type="entry name" value="WHD_HELB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF6">
        <property type="entry name" value="DNA HELICASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13604">
        <property type="entry name" value="AAA_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25894">
        <property type="entry name" value="WHD_HELB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase B winged helix" evidence="5">
        <location>
            <begin position="215"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="162"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="500"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1225"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1287"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1366"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1489"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="849"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="500"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1225"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1293"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1392"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1418"/>
            <end position="1443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS75772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1520" mass="171298" checksum="F9E45319FC7162C2" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B4K4</accession>
    <name>A0A3S1B4K4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GP-PDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_012526</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000432">
        <property type="protein sequence ID" value="RUS79718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B4K4"/>
    <dbReference type="STRING" id="188477.A0A3S1B4K4"/>
    <dbReference type="OrthoDB" id="1058301at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23344">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23344:SF50">
        <property type="entry name" value="GP-PDE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="9">
        <location>
            <begin position="233"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="530"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="577"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="577"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="603"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS79718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="612" mass="69006" checksum="B9DCFFD5CEC6D8CA" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B4Q3</accession>
    <name>A0A3S1B4Q3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isochorismatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_020339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001143">
        <property type="protein sequence ID" value="RUS71901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B4Q3"/>
    <dbReference type="STRING" id="188477.A0A3S1B4Q3"/>
    <dbReference type="OrthoDB" id="269496at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050993">
        <property type="entry name" value="Isochorismatase_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119:SF3">
        <property type="entry name" value="ISOCHORISMATASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="2">
        <location>
            <begin position="13"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS71901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="239" mass="25773" checksum="CF5212CA6592EC50" modified="2019-04-10" version="1">MARRIGKVPSKNTALFICAMQEKFRPTIMYYPQIINVASRLLGSAQALEMPVIVTEQYPKGLGPTVSELDVSQHKVFPKTCFSMIVPDVATELKKHDCLECLHHSGKNQHGRQQKDAGQKAGSPVADDFIGNGGDFACGAHGSGKERGQPLACSVLQIFNSNNSSSTPAIFSAEVTYGVVHSVRRALHGGATLRPILDGEQEKTLRSFRSGRLQDVVMFLGGAGGKGIYKIVEGRSIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B566</accession>
    <name>A0A3S1B566_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SOCS box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_012064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000407">
        <property type="protein sequence ID" value="RUS80175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B566"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SOCS box" evidence="1">
        <location>
            <begin position="240"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS80175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="314" mass="35577" checksum="E3B288FE9E266824" modified="2019-04-10" version="1">MAFEGAISMDIESAIINNDTTVLEKILTQADVNMCLNWKRDSPLFLAVKLSHVSVVQMLLVSPGCNLTHLNANSYSALDLALVIAYDNQREPRQSACWAIVEMLLKANAEPSCPSAMLYVIRSALKLMDETFLCRLINTLVTYCVSVHMHQLLLCKLHRNQPLYAGERGDELLEQASDFTVKVIKRHSDKPSLVRIIACLPYFADSHWTSRERRRAVILKIAVYLSILGWVWSDVYSLAQISPSLARLCYRLPRTVPSLNHLCRLAVLSCPRGRQFLDTTAPKLPKILLNYLNFAEIDAITPFFPDFDFESLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BA85</accession>
    <name>A0A3S1BA85_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UBX domain-containing protein 11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Socius</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">UBX domain-containing protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_008712</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May be involved in the reorganization of actin cytoskeleton mediated by RND1, RND2 and RND3. Promotes RHOA activation mediated by GNA12 and GNA13.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with GNA12, GNA13, RND1, RND2 and RND3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000240">
        <property type="protein sequence ID" value="RUS83533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BA85"/>
    <dbReference type="STRING" id="188477.A0A3S1BA85"/>
    <dbReference type="OrthoDB" id="25887at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17077">
        <property type="entry name" value="UBX_UBXN11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.210:FF:000003">
        <property type="entry name" value="UBX domain protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.210">
        <property type="entry name" value="SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036241">
        <property type="entry name" value="NSFL1C_SEP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012989">
        <property type="entry name" value="SEP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333">
        <property type="entry name" value="UBX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333:SF4">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08059">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102848">
        <property type="entry name" value="NSFL1 (p97 ATPase) cofactor p47, SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51399">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEP" evidence="12">
        <location>
            <begin position="312"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="118"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="422"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00059434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00062345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00075811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS83533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="608" mass="66486" checksum="93F83F14EECB1B6C" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BDR5</accession>
    <name>A0A3S1BDR5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Thyroglobulin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_013812</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000510">
        <property type="protein sequence ID" value="RUS78438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BDR5"/>
    <dbReference type="STRING" id="188477.A0A3S1BDR5"/>
    <dbReference type="OrthoDB" id="5986054at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050840">
        <property type="term" value="F:extracellular matrix binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00191">
        <property type="entry name" value="TY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.10">
        <property type="entry name" value="Thyroglobulin type-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051950">
        <property type="entry name" value="Dev_reg/Prot_inhib"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019577">
        <property type="entry name" value="SPARC/Testican_Ca-bd-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12352:SF30">
        <property type="entry name" value="FI05255P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12352">
        <property type="entry name" value="SECRETED MODULAR CALCIUM-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10591">
        <property type="entry name" value="SPARC_Ca_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00086">
        <property type="entry name" value="Thyroglobulin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00211">
        <property type="entry name" value="TY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57610">
        <property type="entry name" value="Thyroglobulin type-1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Kazal-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="8">
        <location>
            <begin position="11"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="8">
        <location>
            <begin position="217"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="68"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="255"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS78438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="30885" checksum="C99C8D1330750B5B" modified="2019-04-10" version="1" fragment="single">PVCGTNDLTYSSRCELKKAKKCDGLRVRVKHKGQCSEGTIKSTKARRKDNQVLVPTCKPDGTFNEIQCHARTGYCWCVTEDGKHMPGSSVKGRRPNCRGIRIIYKYIYRHIITKIYGTERAIVIWKFEELDKNRDDILKFKEVRNFGRIVKKLIQPRACAKRFVRYCDKVKDRKIEKAEWTLCLGVDIRCNQLLLKCTPNSLNNFYIIMPCNFFVESFTCIDGKRDALALYSQEPDAKHYIPACQSNGMWEKAQCHKETGYCWCVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BEQ2</accession>
    <name>A0A3S1BEQ2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zinc transporter ZIP4 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_010279</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000312">
        <property type="protein sequence ID" value="RUS81964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BEQ2"/>
    <dbReference type="STRING" id="188477.A0A3S1BEQ2"/>
    <dbReference type="OrthoDB" id="200954at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950">
        <property type="entry name" value="ZINC TRANSPORTER SLC39A7 HISTIDINE-RICH MEMBRANE PROTEIN KE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950:SF16">
        <property type="entry name" value="ZINC TRANSPORTER ZIP13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS81964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="23703" checksum="29E47846632ED751" modified="2019-04-10" version="1" fragment="single">NFERSPKSLDSDAVQDSLKQLRDSKTYIQQPESINGNSHIRHRQGKSVTKLGDKDAKESVPEKEIKIKVSGYLNLLANVVDNFTHGLAVGASFCISVKVGLATTLAILLHEIPHEVGDFAILLRSGFDWWRAAKAQVCVCASVCTSVRMSVCMCVCWKLTAWILPFTSGGFMYIALVTVVPDLLEEKHGWESVKQVLCICLGVLSMILVTICFDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BFF0</accession>
    <name>A0A3S1BFF0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_009797</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000286">
        <property type="protein sequence ID" value="RUS82451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BFF0"/>
    <dbReference type="OrthoDB" id="10562474at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="10"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="362"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS82451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="564" mass="59211" checksum="9B59852DDDB93637" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BGZ8</accession>
    <name>A0A3S1BGZ8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_008497</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000232">
        <property type="protein sequence ID" value="RUS83746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BGZ8"/>
    <dbReference type="STRING" id="188477.A0A3S1BGZ8"/>
    <dbReference type="OrthoDB" id="10663820at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018617196" description="Ig-like domain-containing protein" evidence="3">
        <location>
            <begin position="30"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="484"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="424"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="639"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS83746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="679" mass="74354" checksum="42A1063E77ED9DE7" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BHG3</accession>
    <name>A0A3S1BHG3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_003847</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000084">
        <property type="protein sequence ID" value="RUS88391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BHG3"/>
    <dbReference type="STRING" id="188477.A0A3S1BHG3"/>
    <dbReference type="OrthoDB" id="6280085at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051581">
        <property type="entry name" value="Ca-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34524">
        <property type="entry name" value="CALCYPHOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34524:SF15">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="540"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="122"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS88391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="636" mass="72250" checksum="6373B8622472A48F" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BIF2</accession>
    <name>A0A3S1BIF2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_003212</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000068">
        <property type="protein sequence ID" value="RUS89041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BIF2"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS89041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="121" mass="13977" checksum="241A97BFB090E86F" modified="2019-04-10" version="1" fragment="single">VTKEPLNYIVTTTSQKNRVNRMVTTASQKNRINYMVTTTSQKNRVNYMVTTASHKNRINYMVTSASHKKRINYMVTTESQKNRVNETVTTASQKNRVNYMVTTASQKNRINYMVTTASQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BKX5</accession>
    <name>A0A3S1BKX5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_001511</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000026">
        <property type="protein sequence ID" value="RUS90707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BKX5"/>
    <dbReference type="STRING" id="188477.A0A3S1BKX5"/>
    <dbReference type="OrthoDB" id="422220at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048617">
        <property type="entry name" value="MDN1_AAA_lid_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21108">
        <property type="entry name" value="MDN1_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase dynein-related AAA" evidence="4">
        <location>
            <begin position="25"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Midasin lid" evidence="5">
        <location>
            <begin position="158"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS90707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="241" mass="26793" checksum="E085F7C27D8B6916" modified="2019-04-10" version="1" fragment="single">MHTESADFLGGLRPVRSHEDQESDQKLFEWKDGPLVQAMRDGAMFLIDEISLADDSVLERLNSVLESDRMLLLAERVGGGDGDLEGEVEKLEAADGFQVFATMNPGGDFGKKELSPALRNRFTEIWCPQSRDRADLESIIEKNIRSDIHLRNTQDGTSGFGAAIMDFIEWFTSTNVGKRTTVSIRDLLCWVRFINICCEVMASPNTPSAMEVDDDSSTKPNQTKLSPEVAFVHGACLVFID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BMC9</accession>
    <name>A0A3S1BMC9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribonuclease H2 subunit B wHTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_021821</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">The RNase H2 complex is a heterotrimer composed of the catalytic subunit RNASEH2A and the non-catalytic subunits RNASEH2B and RNASEH2C.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase H2 subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001414">
        <property type="protein sequence ID" value="RUS70413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BMC9"/>
    <dbReference type="STRING" id="188477.A0A3S1BMC9"/>
    <dbReference type="OrthoDB" id="29098at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.120:FF:000002">
        <property type="entry name" value="Ribonuclease H2 subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040456">
        <property type="entry name" value="RNase_H2_suB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019024">
        <property type="entry name" value="RNase_H2_suB_wHTH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383:SF11">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09468">
        <property type="entry name" value="RNase_H2-Ydr279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonuclease H2 subunit B wHTH" evidence="4">
        <location>
            <begin position="32"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS70413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="231" mass="25642" checksum="81F12B34287E4BE7" modified="2019-04-10" version="1" fragment="single">TTTTAAAASATTITISTTSLITPRLFHFIFVQAKKFMTLDQLVCDQDFPDCAKLLPACSADQVSLICDSKDIDDDTRVFRYNKDKTLAWLKQKTEALADALAEKNVQVSSKGSHSSIFVRSKSSATSRESYVEFAHGIVSEYLCLSLEEELKNYLGIQEKNERDQESLAENEPPSKKSKLMEDIKPMDDYSIGVDLKKAKKNAKLTTAQKQLSKVDKSGMKSISSFFSPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BMK5</accession>
    <name>A0A3S1BMK5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_007944</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000210">
        <property type="protein sequence ID" value="RUS84300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BMK5"/>
    <dbReference type="OrthoDB" id="8987630at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS84300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="110" mass="12045" checksum="5FF7C3E54341FCE3" modified="2019-04-10" version="1" fragment="single">LQGTLLIERLRGIDDLMGICQGTEVKVILGVHARRDVDVELEKLQDLFALPASHLHVVHLDVLEYLAEVDVPDSLVVPDFGGEDDGAQHHALPVARVDVDLRVGQQALQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BNY1</accession>
    <name>A0A3S1BNY1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bardet-Biedl syndrome 10 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_004138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000093">
        <property type="protein sequence ID" value="RUS88085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BNY1"/>
    <dbReference type="STRING" id="188477.A0A3S1BNY1"/>
    <dbReference type="OrthoDB" id="9393833at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042619">
        <property type="entry name" value="BBS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14667">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14667:SF2">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS88085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="586" mass="64886" checksum="DA87D3C34BD5526B" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BR58</accession>
    <name>A0A3S1BR58_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">GAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_002762</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000055">
        <property type="protein sequence ID" value="RUS89465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BR58"/>
    <dbReference type="STRING" id="188477.A0A3S1BR58"/>
    <dbReference type="OrthoDB" id="295473at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="3">
        <location>
            <begin position="18"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="138"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS89465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="239" mass="26913" checksum="7E77C429486D0FFF" modified="2019-04-10" version="1" fragment="single">ILFLQAVGDSVLQEEVRFAGPTSCFANALETKQPITLEDIPMDRRQEVEKIIRRQVHSLLCVPVCISDSKDLLALACVVNKSNDQEFTESDAEIIRQCFKYTATVLTSTLAFQNERKLKNQTQALLQVARKLFTRLDDLTKLLREIMQEARNLTDAERCSVFLIDKDTDELVAMVFDGITADDKEVQGEIRLPKTQGIAGHVATTGTLLNIRDAYSHPLFYRGIDDSTGFRTRSVLTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BS77</accession>
    <name>A0A3S1BS77_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_004703</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000108">
        <property type="protein sequence ID" value="RUS87527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BS77"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS87527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="246" mass="27541" checksum="19DC053C8F833A62" modified="2019-04-10" version="1">MLKIALYQLAEIGKVLPTECVKKGDDDYNDPADVVTAADDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDKVDAAAATDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDVMVMMMMVVVVVVVIMVACSRHPETPGMPPFWTEVFMYPFSVSSSDGWRKQEKAGESRRNQEKELASRTDTPNQALWSRRDRNKRIMNIHEAREPPESGRPDTPTSRSSTSSRAVMVDNGLETTEAAPETSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BSX8</accession>
    <name>A0A3S1BSX8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA excision repair protein ERCC-6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">ATP-dependent helicase ERCC6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Cockayne syndrome protein CSB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EGW08_018111</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">EC2010</strain>
            <tissue evidence="17">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000863">
        <property type="protein sequence ID" value="RUS74131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S1BSX8"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21397">
        <property type="entry name" value="cc_ERCC-6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22254">
        <property type="entry name" value="CSB_WHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18000">
        <property type="entry name" value="DEXHc_ERCC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000863">
        <property type="entry name" value="DNA excision repair protein ERCC-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000042">
        <property type="entry name" value="SNF2 family helicase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059240">
        <property type="entry name" value="cc_ERCC-6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058951">
        <property type="entry name" value="WHD_Rad26_CSB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25875">
        <property type="entry name" value="WHD_Rad26_CSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="499"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="820"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="260"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="998"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1196"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1342"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="265"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="359"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="386"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="412"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="436"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1015"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1221"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1232"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1276"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1345"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1380"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1395"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1412"/>
            <end position="1427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00076356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00079118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RUS74131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1542" mass="176463" checksum="FF46BD38EA8163A9" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BTQ1</accession>
    <name>A0A3S1BTQ1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_003778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000082">
        <property type="protein sequence ID" value="RUS88441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BTQ1"/>
    <dbReference type="OrthoDB" id="6161418at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="350"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS88441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="392" mass="40613" checksum="E0A12D7A86426EC6" modified="2019-04-10" version="1" fragment="single">MNSYFAASFLPQYSPESHYSANGYGSSTASNYGLYSSRFSDHLGGYHQAAAAAAASASSQAAVGGYGGPGGSGGAGGSSGLHHSPVPGVTGLVSESCASAYGPYHAAQKAASLGLQQSHHAHLGTASSSPYGGAGRGMSPVHHHHHQHQQHPHLGSPNDLAVATSGYPITPAHAHTGHLTPVHEKYGNNNNNNNSISTNGGVITSNTHSMNKTGSPSSSSPSPYGHHHGGLQQQQQHNTNGVGSASNGASPFSNSNVGTATTNSLNSHGLGDSESPPLMGSSNNHHNNGNISNTTSNNNNIHSQQHWPKHASTPSPTRSQHSPFGSPGEPNNLSTCSLSPKEAGDDQTIQRQQQQQQQQQQHHQHQLQQQHSQSSGSSPEQAAPFYPWMGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BUB3</accession>
    <name>A0A3S1BUB3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_003353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000071">
        <property type="protein sequence ID" value="RUS88914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BUB3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS88914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="201" mass="21529" checksum="49ACD84C3709DCF6" modified="2019-04-10" version="1" fragment="single">MVDPLRLLQLLLPGLGHFLHEFLRLGEALRQVRLAERLTCLCCLELSLEHLHLLAQLADDAGVGVLVDHGVVDDPLGAVSVAQSGKRLLVVVCRGADGGHHDRLAVASQRAYLQEPGEHRVPVGHKLVLVLAAARLVSQGRDDQAEGGQRSDAGHKQFWLYRLLVDVASLLEAVAHGPSLLGALTASQVHQGQLADLLAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BUG2</accession>
    <name>A0A3S1BUG2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_000670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000009">
        <property type="protein sequence ID" value="RUS91555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BUG2"/>
    <dbReference type="OrthoDB" id="6038751at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS91555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="190" mass="22171" checksum="2D09E9891F596DAA" modified="2019-04-10" version="1">MNICTTKNERPLNLTQSEVFLNGKDKAVVWSGPPHLVPTYPNWKELRAVRYNPRLTRKDEKTFRAEENWTEYHRQRHLPSGYYGHSIGTQPSGVPGLRLDGYTRHIHGMPPRDIFLHHWPKADSWLQPARAPRGEYYGYYHEALESERFMRDRLRSTRERITPCDIPRVTSLSCKQVLRDVDCDLGGGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BXT6</accession>
    <name>A0A3S1BXT6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_014583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000562">
        <property type="protein sequence ID" value="RUS77660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BXT6"/>
    <dbReference type="OrthoDB" id="6262491at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="526"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS77660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="712" mass="76275" checksum="4618647156332687" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BY05</accession>
    <name>A0A3S1BY05_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_014458</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000552">
        <property type="protein sequence ID" value="RUS77794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BY05"/>
    <dbReference type="STRING" id="188477.A0A3S1BY05"/>
    <dbReference type="OrthoDB" id="5877963at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015501">
        <property type="term" value="F:glutamate:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015175">
        <property type="term" value="F:neutral L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="entry name" value="Sodium:dicarboxylate symporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050746">
        <property type="entry name" value="DAACS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018107">
        <property type="entry name" value="Na-dicarboxylate_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958:SF63">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958">
        <property type="entry name" value="SODIUM/DICARBOXYLATE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00173">
        <property type="entry name" value="EDTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="Proton glutamate symport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00713">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="446"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS77794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="471" mass="49457" checksum="23FF8FCC2C8CB1E8" modified="2019-04-10" version="1">MRERTAHYGTLREVDDEESAEIGHSGKSDSNSANSKLKDQGHATRTATTSPKSPAAESASCAKRLARHARNNLLLVALASALVLGVVLGVAVRLLAPPLNAAQQEYLEFPGEILMNMLKLLILPLIVSSLISGMTTLDSGASGAHSRRELVQEDGINMLGLVVFSLAVGVGINHIGEPARPLRDLVQALMDVTMFLVNAVIWYSPVGILFLVAGQVAGLADAGESVRQLGMYMLTVLVGLALHGLVVLPLIYFTLVRKNPYRFMGGVLEALVTALGTSSSSATLPVTMRNLQENNGIDPRVISFVIPVGATVNMDGTALYEAVATIFIGQVNGLDLNLGKIITICITATAASIGAAGVPQAGLVTMVIVLDSVGFPTSGIAMVLAVDWMLDRVRTVVNVLGDAYGAGIVNHYSRDEAGGLSSDNQMPLLPGESPATETVVVTEGKPRTNGLHVSSSAGLGSPEQQTSFYQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C3V5</accession>
    <name>A0A3S1C3V5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_009952</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000293">
        <property type="protein sequence ID" value="RUS82274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C3V5"/>
    <dbReference type="STRING" id="188477.A0A3S1C3V5"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="23"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS82274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="346" mass="39188" checksum="0D3FDB45DF94315A" modified="2019-04-10" version="1" fragment="single">QDEDEYIGFATLPEQVHRKAVRKGFDFTLMVVGESGMGKSTLINSLFLSDLYKDKNSPSVNDLVERTVSIEKKQLEIEEKGVRLKLTIVDTPGFNDAVNAENRLGGLGCLKPLFFLIGCLHSLLLLPHSLRQIDVQTMRKLHNKVNIVPLIAKADILTKQELRTMKDRVMDEIEQHKIRIYEFPECDSDEDDDFKQQDRELKASIPFAVVGCNTVVEAGGKKIRGRAYPWGIVEVDNPSHCDFVRLRQMLISTHMQDLKDVTSDVHYENYRAAHIRTQLGSATRERTKLKRDSGANQENVAETEKLLEEKDAEIQRMQAMLAKMQAQLQGQGQGQSQKQVNGLGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H5S9</accession>
    <name>A0A3S1H5S9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_019456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001018">
        <property type="protein sequence ID" value="RUS72796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H5S9"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS72796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="131" mass="13602" checksum="00623ED6F1E711EE" modified="2019-04-10" version="1">MNYLACDAKAGSKPCKCEKKGDDYTATLEFKVKTALNNGDVQAIWVATKPAPAPVAPVPAEAAAGGADNATTPIEPAPMSAEKKNMVQTANVGVVKDKCEKSKTTGGAAETALVSFWLNFLCLAMANLVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HNE0</accession>
    <name>A0A3S1HNE0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_009325</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000266">
        <property type="protein sequence ID" value="RUS82902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HNE0"/>
    <dbReference type="STRING" id="188477.A0A3S1HNE0"/>
    <dbReference type="OrthoDB" id="5975505at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14993">
        <property type="entry name" value="7tmA_CCKR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF15">
        <property type="entry name" value="OPSIN RH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="263"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="116"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS82902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="466" mass="51865" checksum="9A0D5B4115F81A0E" modified="2019-04-10" version="1">MGSQAHGSSGLNPKLSVSGVAPYKNNQTTFIIIQPGSAAVDSAVRDMFNYSSEYSVADCGMNCTGLENMFTGQGNSTASPEPAVTEEYYKLVKQPVFMLVILSVSYGIVFLLALLGNISVIIVVARDKSLHTATNFFLVNMAVADMLVAIFCLPLTLLSNIYTGWQFGAIMCKAVPYLQGVAVCASVCTLVVIAVDRYIAICHVMRQRNTKRMARTILIIIWLLAMTLMTPWALFYKHLEYRTTLQIIYICLPDFPDVTQSRIFFLAVIFLVCYALPLTFIVVCYSMIGYRVCHRNAPGITSSKGVIQKSKIRVVKMLVVVVVLFAFSWMPLYIINLKMNFFPPPSRSAEMDVIQKVLIPFAQWLGTSNSCMNPLVYCLFSQKIRRRIKALLCCSSPDFLNHESTTVGGVRWSSRRLEINSTIEAHSRKTSFSSSGSQYSSFFIHRSAGLCHDTGDRAKRSSSTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1I266</accession>
    <name>A0A3S1I266_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lipid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_001410</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty acid desaturase CarF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000024">
        <property type="protein sequence ID" value="RUS90791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1I266"/>
    <dbReference type="STRING" id="188477.A0A3S1I266"/>
    <dbReference type="OrthoDB" id="5103at2759"/>
    <dbReference type="UniPathway" id="UPA00199"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019547">
        <property type="entry name" value="Lipid_desat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052601">
        <property type="entry name" value="Plasmalogen_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48177:SF1">
        <property type="entry name" value="PLASMANYLETHANOLAMINE DESATURASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48177">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10520">
        <property type="entry name" value="Lipid_desat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid desaturase" evidence="7">
        <location>
            <begin position="96"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS90791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="282" mass="32423" checksum="1C904013E093C796" modified="2019-04-10" version="1">MGVKSATEIINNSMTEEDPNKNIQYSEGAAAQKPRWGPEHAGAKELASKYTRGKRLQETVCFFISIVLLVFNFICLVWYFDSSHWHMILLCALLGILTADFASGLVHWGADTWGTVELPIIGSGFIRPFREHHIDPTSITRHDFIETNGDNFAVCIPVMGYCAYQFLFLPREAIPASYNWMMYLFLLCVFVSLTNQCHKWSHTYFGLPWYIKLLQDLHLVLPRRHHRIHHVSPHETYYCITTGWLNYPLELIGFWSTMEVIIEGITGSKPRSDDMAWASKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1I3R7</accession>
    <name>A0A3S1I3R7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">EGW08_000635</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">EC2010</strain>
            <tissue evidence="22">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>Ca(2+)(in) + 3 Na(+)(out) = Ca(2+)(out) + 3 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:69955"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000008">
        <property type="protein sequence ID" value="RUS91662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1I3R7"/>
    <dbReference type="STRING" id="188477.A0A3S1I3R7"/>
    <dbReference type="OrthoDB" id="418484at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005432">
        <property type="term" value="F:calcium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000003">
        <property type="entry name" value="sodium/calcium exchanger 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051171">
        <property type="entry name" value="CaCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004836">
        <property type="entry name" value="Na_Ca_Ex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11878:SF65">
        <property type="entry name" value="NA_CA-EXCHANGE PROTEIN, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11878">
        <property type="entry name" value="SODIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01259">
        <property type="entry name" value="NACAEXCHNGR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="18" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="21">
        <location>
            <begin position="139"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00033667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="RUS91662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="312" mass="33550" checksum="35D21CBCCF8E645D" modified="2019-04-10" version="1">MPPAARALPSLWCSPGKGEDVDSGAVVNSEDDRMAEMGKPRLGELTKTTIRIKESQEFKSTVDKLLKKANVSLVVGTSSWREQFVEAITVSAGDDDADDEEGEESEEKLPSCVDYVMHFLTLFWKILFAFVPPTDYGGGWWCFCVSITLIGVLTAFIGDLASSFGCTVGLKDSVTAISFVALGTSVPDTFASKVAAIGDRYADSSIGNVTGSNAVNVFLGIGIAWTIAAVYHAMNGNKFYVPPGELALSVTVFCIMAGLTIAILLLRRHSSIGGELGGPMKYKLPTTIILVVFWLIYVLISSFASYCYIPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SI64</accession>
    <name>A0A433SI64_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_023864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01006051">
        <property type="protein sequence ID" value="RUS68374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SI64"/>
    <dbReference type="OrthoDB" id="6262491at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.150.10.10">
        <property type="entry name" value="Serralysin-like metalloprotease, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS68374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="115" mass="12045" checksum="01DB9E9AEB3DB171" modified="2019-05-08" version="1" fragment="single">SDTKDNPVANKLNTAPDNPNKTTTDGPNTVSREPNSVADEPNTVSDVPKLVANGSNTVSHEPNTVSHEPNTVADEPKIVVKRSSTAAGEQNPNDVADESNTVADETNVVNEINTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SJD1</accession>
    <name>A0A433SJD1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Myosin tail domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_023072</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001800">
        <property type="protein sequence ID" value="RUS69164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SJD1"/>
    <dbReference type="STRING" id="188477.A0A433SJD1"/>
    <dbReference type="OrthoDB" id="5984396at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46292">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 102A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46292:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 102A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="79"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="202"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="308"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS69164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="39828" checksum="28A8BE4C9DA52A34" modified="2019-05-08" version="1" fragment="single">WSEREEALAAELEEAKIRVAQMEKTMRWWSDCTSNWREKWNKARGERNKAKDENRLLRAKLEALAKEVTRLRRERKEALAQEKNVMSPSNEDQADSQLHAIPTPSSLTEDGQNSGNKSSNSQGGLSEKEKTVIAGTDEKEEKNSHMELVEQLQVEVKTLKSSLEEEKQGKQETIMQMDKVKTQHQDELSRLTLDLEDEANSRSTMDKQVSELRRDLERIQAENASEWAKRERLESEKLALERDNKKLRAQVTDLEEELQKRSQATSSIVDSDLKTLQFELTENQKELSDVRHSQVKLRKVLGERGTELEHTRRRAEQYQDEVRKLRGRVEELKHDLAAAEDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SJU4</accession>
    <name>A0A433SJU4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_022891</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001718">
        <property type="protein sequence ID" value="RUS69345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SJU4"/>
    <dbReference type="OrthoDB" id="6086192at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47403">
        <property type="entry name" value="LOC100145250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47403:SF6">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="7"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS69345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="368" mass="41939" checksum="42DF6C0A720DE442" modified="2019-05-08" version="1">MSSAPDVTIRRALLSDEAAVMSLGDVYSGRDYLFALYSDLVQDPDTYPVVAVVNNVVVGFYLTEPFDGGVTVIKRAGRVAESYRGRGVFHLMEAELERHTAHERSQVMYEAVARTDKVDHLIDRFLSKGYRPVYRKGIMNKLLKPSNYGRQGNNTHLTLDLKEMSRQDLSLMFHAENDEPRLFPQKRLFNFYLGYRLMDENIPSILCKGGGAFYSATKNDVRTDGCEPYHKPNGNVQSQNGSSHIRTIDNRSSSADSNMKAKINDVKRIAMVTFYRFLPTRTGYLYFLDVYATPEAVTSRDYLQSHLQRHLFTARRHFPKTNGILCVAHDLHIPKDLISSSLAQLGICEDLEGQEDFQVLYEKNDIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SJY6</accession>
    <name>A0A433SJY6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein dpy-30 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_022807</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dpy-30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001685">
        <property type="protein sequence ID" value="RUS69426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SJY6"/>
    <dbReference type="STRING" id="188477.A0A433SJY6"/>
    <dbReference type="OrthoDB" id="417678at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22965">
        <property type="entry name" value="DD_DPY30_SDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.890.10:FF:000003">
        <property type="entry name" value="protein dpy-30 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007858">
        <property type="entry name" value="Dpy-30_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049629">
        <property type="entry name" value="DPY30_SDC1_DD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037856">
        <property type="entry name" value="Sdc1/DPY30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23356:SF16">
        <property type="entry name" value="DPY30 DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23356">
        <property type="entry name" value="DPY30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05186">
        <property type="entry name" value="Dpy-30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS69426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="91" mass="10029" checksum="A626CD2F35712D0D" modified="2019-05-08" version="1">MSVTDATANDAAESQDVPENIQKIISSEKELAEVPSKKSKVDLQSLPTRAYLDQTVVPILLTGMSVLARERPPNPVEFLAAYLLKNKDQFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SKQ2</accession>
    <name>A0A433SKQ2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">protein O-GlcNAc transferase</fullName>
            <ecNumber evidence="5">2.4.1.255</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_022546</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.255" evidence="5"/>
    <dbReference type="EMBL" id="RQTK01001603">
        <property type="protein sequence ID" value="RUS69693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SKQ2"/>
    <dbReference type="STRING" id="188477.A0A433SKQ2"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000013">
        <property type="entry name" value="UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000019">
        <property type="entry name" value="UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11380:FF:000001">
        <property type="entry name" value="UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000012">
        <property type="entry name" value="UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037919">
        <property type="entry name" value="OGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029489">
        <property type="entry name" value="OGT/SEC/SPY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44366">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44366:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13844">
        <property type="entry name" value="Glyco_transf_41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 12" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="76"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="110"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="178"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="212"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="246"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="280"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="314"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="348"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="382"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="416"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="O-GlcNAc transferase C-terminal" evidence="13">
        <location>
            <begin position="463"/>
            <end position="1007"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS69693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1043" mass="116531" checksum="A64BC56614138D6F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SN53</accession>
    <name>A0A433SN53_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_021584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001360">
        <property type="protein sequence ID" value="RUS70647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SN53"/>
    <dbReference type="OrthoDB" id="6120233at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS70647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="504" mass="58323" checksum="87595258B6F2830C" modified="2019-05-08" version="1">MRVPAEEAGERSVQDQRGWKTSLRDLVPTMHRRWAKNYVRAWRQKHLANGTTTGSSDGEKVQKVTPEEADVPPPYVQYVDTQVFRLHKVWAQERPGKITPEFEEAKAAVPMAFQNWIRWYLKKTFGPNRVPRFRPIKGEKDSKGKEGQQKQEQEKENAKEPSEKKKSKKEKEANEWKTEWKAMRKHIRDAVPLSDRDWTKAFIKQWRLDNLEEADRGRYIAETSPNSSSSSSSDSDDGVKDGKSVSKEGPENYDTWLGLYLTQWHSNQGDALPKQNAKEASQELKKITDTQVPPSYRKWVKFYIGRVLSKVKKDKQKEAEVLARRQYYGWMARFQEKWVAKQDGATSASSGDDTDMDRSSKKKAKTAPDASVRPKIIIERLQSIIDSDGEYENEMPVQPLQKPPSEFRQWALEIFRDWDGVTLGYGLPATSPATSREEDEEPEIPPGVYNWMRKAFARLEIKRLRTELRACRREKEKEQQGGKTDDGKKNPQKGDKSSKHVHQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SP93</accession>
    <name>A0A433SP93_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_021199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001282">
        <property type="protein sequence ID" value="RUS71041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SP93"/>
    <dbReference type="STRING" id="188477.A0A433SP93"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="447"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="496"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS71041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="528" mass="54813" checksum="B88032D23910FCAB" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SQS6</accession>
    <name>A0A433SQS6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">P/Homo B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EGW08_020640</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">EC2010</strain>
            <tissue evidence="17">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S8 family. Furin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001190">
        <property type="protein sequence ID" value="RUS71596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SQS6"/>
    <dbReference type="STRING" id="188477.A0A433SQS6"/>
    <dbReference type="OrthoDB" id="300641at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016486">
        <property type="term" value="P:peptide hormone processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04059">
        <property type="entry name" value="Peptidases_S8_Protein_convertases_Kexins_Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000001">
        <property type="entry name" value="Furin 2, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000006">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.850">
        <property type="entry name" value="Peptidase S8, pro-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034182">
        <property type="entry name" value="Kexin/furin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032815">
        <property type="entry name" value="S8_pro-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038466">
        <property type="entry name" value="S8_pro-domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF14">
        <property type="entry name" value="NEUROENDOCRINE CONVERTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16470">
        <property type="entry name" value="S8_pro-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 13" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018998798" description="P/Homo B domain-containing protein" evidence="15">
        <location>
            <begin position="24"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="16">
        <location>
            <begin position="474"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="620"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="12 13">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="12 13">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="12 13">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RUS71596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="684" mass="75315" checksum="12721448C1B3918E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SRD3</accession>
    <name>A0A433SRD3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_020448</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001158">
        <property type="protein sequence ID" value="RUS71795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SRD3"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117:SF8">
        <property type="entry name" value="KINESIN FAMILY MEMBER 16B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="START" evidence="2">
        <location>
            <begin position="251"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS71795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="447" mass="49786" checksum="70C9E5DEBEC94911" modified="2019-05-08" version="1">MLVNNPSVLLSSLDEYISLRRLQKTPLTTITLPQDLTGTDIESSDTSHDQESLTQDTPLLKKVRNFILDRNSSSSGLGGSNGTDLSRKIVLKRYSSILKYGHKDDSGKEGSGAQGSDLSNDSKGFTPLFTSETKPDNADRVTPLHPTLKRSVSDGMALKQSLKMNRELSEVGKLSEGNESDGDDLTDTDAEDHDEADHVYNGDPLSPEDLRKAGFKTLSNQSAAEILAEAMRASNIDLELSAEEQAESSGGWLFSCFEKNIVVLKKQQQNGSTVQSYIGKGFVLAPPKTVWDAVRNPRIRFTYDDTIKKVDIMETLDNSLKIVYFYHESQQFLMKENCDMCILHGERHDGDKFVLTYSSIEHDKCPVLPGVTRAKFLPSGWIIEPARQDNKVYSIVTYLMQIDFGGNPSSRSSLPFQDMISRYPLSIADLQQYLKPAVQLLRRKSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SS76</accession>
    <name>A0A433SS76_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_020128</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001113">
        <property type="protein sequence ID" value="RUS72102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SS76"/>
    <dbReference type="STRING" id="188477.A0A433SS76"/>
    <dbReference type="OrthoDB" id="1703270at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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            <begin position="1"/>
            <end position="36"/>
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            <end position="14"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00005257"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022980"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000669"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS72102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="208" mass="24026" checksum="A14271D6DAD6E08A" modified="2019-05-08" version="1">MGISRDRRHKRRATGGRMSPLSKKRKYDLGRPPSHTRLGVKRIHTVRTMGGNKKYRALRQDHGNFAWGSEACTRKTRIIDVVYNASNNEFVRTKTLVKSCIVQIDSTPFRQWYEAHYATPLGRKKGVKLSEEDEAILNKVRSKKTQKKYDERKKTAKVEFALDEQFSAGRVYAKISSRPGQCGRVDGYILEGKELEFYTRKLKSKKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SV94</accession>
    <name>A0A433SV94_ELYCH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_019026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="RUS73204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000271974">
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    </dbReference>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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        <location>
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        </location>
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        <location>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="RUS73204.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="2373" mass="259322" checksum="406E7F8CCAC3DEDA" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SXM7</accession>
    <name>A0A433SXM7_ELYCH</name>
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        <recommendedName>
            <fullName evidence="1">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_018302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
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        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
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            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000884">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10259057at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070382">
        <property type="term" value="C:exocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
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    </dbReference>
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        <property type="term" value="F:calcium ion binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
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        <property type="term" value="F:phosphatidylserine binding"/>
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    </dbReference>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="175"/>
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    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
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    </evidence>
    <sequence length="175" mass="19966" checksum="289FAE2F050BDD52" modified="2019-05-08" version="1" fragment="single">MQTKIHRRTDNPVFNEGYDVSVDSANITSYVVKFLVCDFDRFSRHVNVGEVTSDLSKLELRPSKEVLFNDLIEGYNEEELGEIHVALMYLPTAEKLSVTLLNARSLPALEGTKKNMETYVKLLMMYDGRPIKKSKTACRKATDSNPVYNETFVFDVPPYQLDKVYFNLAVIGVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SXP7</accession>
    <name>A0A433SXP7_ELYCH</name>
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        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_018142</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000866">
        <property type="protein sequence ID" value="RUS74095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SXP7"/>
    <dbReference type="STRING" id="188477.A0A433SXP7"/>
    <dbReference type="OrthoDB" id="6147321at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF372">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="440"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="46"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS74095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="522" mass="56821" checksum="F902964D14736921" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SXQ5</accession>
    <name>A0A433SXQ5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_018160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000868">
        <property type="protein sequence ID" value="RUS74082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SXQ5"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS74082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="279" mass="30645" checksum="DBA90657FC3C3375" modified="2019-05-08" version="1">MTALWHARVSSADGKVSPQLPPDSNLLTKRAAFGQPLCELIMRGSGGGVDAELGTWTLRGGAGGGVAWAWDGRQLTWRSPGQAAPRGLYHCGSGQVLWTVLGKRWSEMWRNQLKKKIEWKSLCSALGIASHHPDKTLPLWLRQQLAASHAGPISPVLSLLVRGREALETADVLDTATFQGLGVVTVPAARQEGAVHVVRTDRSGSFNAGWQESWARMARTKFSNGWDEFEETGRLIGSVDGDTLQRKKRLYRLHFTRTSLMCEMRGNATQCSSEFPPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SYW9</accession>
    <name>A0A433SYW9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_017747</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000826">
        <property type="protein sequence ID" value="RUS74496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SYW9"/>
    <dbReference type="STRING" id="188477.A0A433SYW9"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000286">
        <property type="entry name" value="PH-protein kinase domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336:SF15">
        <property type="entry name" value="DUAL ADAPTER FOR PHOSPHOTYROSINE AND 3-PHOSPHOTYROSINE AND 3-PHOSPHOINOSITIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="3">
        <location>
            <begin position="14"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="142"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS74496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="29754" checksum="F08A98D72B9CD9E9" modified="2019-05-08" version="1">MNGIENFEVESLPWYHPTLSRHTAESMLIQNGLDGTYLLRPSSKGSGEYALSVKCEQAVKHFNIVWAGNEIRFGQCTFNNAADFVEHFKNKPLLCGESGQVVLLKIPYPRDISEPDMYECVTLHAEFSTADDPRITDTDFSVNSKEGFLTKQGRHFKSWRTRWFVLQRNELKYFKQKFSKNPLRVLDLNECRECSQDFSQKDKSCVIRLDMGWRVFLFYSVSEHDMEDWIKRINWRLKANRTRGSFNSDHSNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SZ97</accession>
    <name>A0A433SZ97_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_017597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000812">
        <property type="protein sequence ID" value="RUS74643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SZ97"/>
    <dbReference type="STRING" id="188477.A0A433SZ97"/>
    <dbReference type="OrthoDB" id="6111527at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS74643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="201" mass="22144" checksum="A04E4CB496765FCD" modified="2019-05-08" version="1" fragment="single">SSLSQSVADVVEFELEYAKFTNVELSVATGEEDDRDTASAGFRKRGSPVNLGVLSTMVTALIAQASLVMGERVSMLANSLPDHITQKLSLITEKDQRTGYTYPIMNETTIVALEELAHMLLNIKTTLGFDVHNASENALATLASISAKQDKRPSSVDSQILNDPQVFQRRPKAGQKILEDDMLYKPRVTQMYKPRIEQSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T0L8</accession>
    <name>A0A433T0L8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Neurotransmitter-gated ion-channel ligand-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">EGW08_017150</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">EC2010</strain>
            <tissue evidence="18">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Synaptic cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000772">
        <property type="protein sequence ID" value="RUS75096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T0L8"/>
    <dbReference type="STRING" id="188477.A0A433T0L8"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18997">
        <property type="entry name" value="LGIC_ECD_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000073">
        <property type="entry name" value="Neuronal acetylcholine receptor subunit alpha-9-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000016">
        <property type="entry name" value="Nicotinic acetylcholine receptor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="484"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="16">
        <location>
            <begin position="56"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="17">
        <location>
            <begin position="269"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RUS75096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="57872" checksum="F9A981E836863516" modified="2019-05-08" version="1">MRFQLVSHTATITASVEGVVCQGSGGEDIVEEEEETVAASSQKILGDSYEYNVTDETRLIDNILSGYNPASRPVYNASHTVTVKFGITLTQISDMDEVNQVLTMNVWLEQEWEDERLTWDPQDYNNLYILRLPCELLWLPDIVLYNSADDFTTGYMKSKAMVYSNGTVFWAPPARFRSSCKIDITYFPFDDQSCELKFGSWTYDGFQVDVTNRTSRVDLQNYVYSGEWELIDVRIRRTVVKYACCVETYPDVRFTVVIRRKTLYYLFNIIFPCLWLTILSLLGFWLPPESGEKITLGITVLLAFSVFMLLIAESMPATSEFVPLMGIYLTITMGMTSMSIILTVFVLQLHHVGPHKRPVPGWLNTLVVGVFSRLVCIPGEHDACYSPLISHSQCTLLCPSSSQTAHSSATRPRNCDQGQQDMSADSFHFSQGQGTTLQNSPKPRLSFMQAGMMCQSGCMEGPALEHYQQLVLEWQFVAHVMDRLLFWLFLALAIVCSLAILVIKPLFKPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T1W9</accession>
    <name>A0A433T1W9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_016658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000727">
        <property type="protein sequence ID" value="RUS75594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T1W9"/>
    <dbReference type="OrthoDB" id="10599939at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS75594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="615" mass="68586" checksum="81396F18F5F95A03" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T7S3</accession>
    <name>A0A433T7S3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_014674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000571">
        <property type="protein sequence ID" value="RUS77570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T7S3"/>
    <dbReference type="OrthoDB" id="10429914at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS77570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="129" mass="13884" checksum="C0785BFF42E8DC2D" modified="2019-05-08" version="1" fragment="single">QKTQKVPEDPLIYGPFSEKEDIPPRPGNDQPFPTHGPRIPDMFDVHGTRVGQTSRPSRAPKVTIGLGRGANISVGISTNHSSHGAPSATFTAQATRKPNGAFNVRVNLNANLGNRNKPGSNSYSFGNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T894</accession>
    <name>A0A433T894_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_014499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000556">
        <property type="protein sequence ID" value="RUS77740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T894"/>
    <dbReference type="STRING" id="188477.A0A433T894"/>
    <dbReference type="OrthoDB" id="413122at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="70"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS77740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="436" mass="49367" checksum="85750A918014A25B" modified="2019-05-08" version="1">MKKENEVKTLMVPRMERHVGVDRAELIRLQDEDQAIQAMARLTSPKSRRGKTKTINKGAIPRAPLQNIPVVDVPFKRVAVDLVGPIDPTSEDGHRYILTLVDYATRYPEAVPLKRIDGEAVAGALVNIYSRLGVPEEILTDQDTQFMSACMREVNRLLGITQSATTPYHPMCNGLIERFTGTLKKALRRLCAEQPKQRHRFINPLLFAYRGIPQDSTRFAPFELLCGRTVRGPMHILKQIWTKDIEEDEVRSSYQYVLELRERLERTWEMAQKELEKAQGRQKRYYDRGTKARKFKPGDDVLVLLPTDTNKLLMQWKGPYKVVAVVGINDYRVKMGRKEKTLHANLLKRYVSRSEMEDVDVDSPDTSSTQCARGDKAYSVDVSPSVEPSTEITRTQSNAAVMTHGPAPSPVMSAPETATRELEVVTLSAVAVLYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T8J8</accession>
    <name>A0A433T8J8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_014309</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000542">
        <property type="protein sequence ID" value="RUS77935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T8J8"/>
    <dbReference type="STRING" id="188477.A0A433T8J8"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13291">
        <property type="entry name" value="PH_ORP10_ORP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2720:FF:000001">
        <property type="entry name" value="Oxysterol-binding OBPalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000002">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF141">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="3" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="151"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS77935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="771" mass="88187" checksum="D5B9036D8937D1C6" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T8W3</accession>
    <name>A0A433T8W3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_014296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000541">
        <property type="protein sequence ID" value="RUS77950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T8W3"/>
    <dbReference type="STRING" id="188477.A0A433T8W3"/>
    <dbReference type="OrthoDB" id="432281at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS77950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="144" mass="15451" checksum="BC6C80B41E02B442" modified="2019-05-08" version="1" fragment="single">MSLLHHAVIYQRPGVVDTILVAAPESVNVQDYLKRSPLHYAAMCPPGTEIYQTLVNAQADDSFADVMGKSPLDYASEPNEALLEEAKAKIEQSLKVKPTSPAPTAEEGKQDTSATEDKSSDQIDKSGEQAQAEIDVPAPATAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TBR4</accession>
    <name>A0A433TBR4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">E3 ubiquitin-protein ligase RNF170</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">RING finger protein 170</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">RING-type E3 ubiquitin transferase RNF170</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EGW08_013194</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">EC2010</strain>
            <tissue evidence="15">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000475">
        <property type="protein sequence ID" value="RUS79037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TBR4"/>
    <dbReference type="STRING" id="188477.A0A433TBR4"/>
    <dbReference type="OrthoDB" id="9049620at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16553">
        <property type="entry name" value="RING-HC_RNF170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010652">
        <property type="entry name" value="DUF1232"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038896">
        <property type="entry name" value="RNF170"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22894">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22894:SF5">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06803">
        <property type="entry name" value="DUF1232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="96"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="59"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RUS79037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="271" mass="30061" checksum="E54E224876A22B7A" modified="2019-05-08" version="1">MASYARRTNLIEGVGNEVLLGLGAFTSALVAALYFVNNRGTTAGTIHPDSARHIASTREQLQNEAEASEGGEGQPGGEQTRASRRTHHRNDGQLTCPICLGSAVLAVETNCGHVFCGHCFATYWQHQTWLGAVRCPSCRTQVSLLLINFTAEEHAANSEERTEVLNKINQYNRRFSGEPRTFQEYLQDLPTLLRHAFHEFFSVGGLMWMFRFRIGILVLAAFLYLISPLDILPEAVFGIIGFLDDIFIILLLAIYISIIYRQVVAARGGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TD91</accession>
    <name>A0A433TD91_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Heme-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_012692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000444">
        <property type="protein sequence ID" value="RUS79562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TD91"/>
    <dbReference type="STRING" id="188477.A0A433TD91"/>
    <dbReference type="OrthoDB" id="6424451at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.80.10:FF:000002">
        <property type="entry name" value="Heme-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="entry name" value="Regulatory factor, effector binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006917">
        <property type="entry name" value="SOUL_heme-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220:SF1">
        <property type="entry name" value="HEME-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220">
        <property type="entry name" value="HEME-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04832">
        <property type="entry name" value="SOUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="Probable bacterial effector-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS79562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="22663" checksum="F8C06447B0564CDA" modified="2019-05-08" version="1">MVSTSTVGGYKNINKTTVMFGLMKALVTGSQKPSFVVLDSAKGFEVRKYPPAKWVSTTEKNISHKAGTSAAFRRLFKYIQGENQEKKTVPMTIPVTTKVEPGEGPNCESSFTMAFYLPVEHQERPPAPTDPALFVEDRPELTVFVHTFGGFADDEKWVSHALELSEAIGDQSQYISDFYYTVGYDAPFKLLNRTNEVWFVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TEK1</accession>
    <name>A0A433TEK1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_012260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000417">
        <property type="protein sequence ID" value="RUS79995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TEK1"/>
    <dbReference type="OrthoDB" id="6163175at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS79995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="468" mass="50748" checksum="D19FE16B55F375A7" modified="2019-05-08" version="1" fragment="single">QHQERLQQHQQPSHFPQQQQHQQHLQQQINVASIPLPVPIDKVKQEPPDSDEERRGRKGQGGADAAKAGKAGSPQGPKRPKNYRKKGGGSRSRSSSRSSSRSSASSRSSSYSSRSSSSSSSRDSLSGRDRRRRGRRGGSTRKKRSSRRRRSRRGYRRDSADSYDCYSSDAQAKRFPPGAGGAAGPDRRGGVLPGQPPAAPAAPAVEEDDEPPEMYTSGSEDGELVRRENVPNVPIGVKIKKEPSSDTEQQDEKEALGAAKETPDEQAPPQEAQLQAEPAGGALQTPLGDGQQGQQQSSEAEIKLDQLEQQEQEPGSVDAQEEKLEALSSESSQQLQQNVQQELQTAGVTGSQGESVEKVTAPRPEDSSATKDAAREEGSKDGEDEDGDNDNDDEEEDEEEDDDEEMEEEDSSTALEEGGKEEGEMDQMELLELEMRARAIKAMLSSHGQGGDQGGDQTGEDLQIKATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TJW5</accession>
    <name>A0A433TJW5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_010423</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000319">
        <property type="protein sequence ID" value="RUS81831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TJW5"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS81831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="237" mass="26758" checksum="C91797479C8AE625" modified="2019-05-08" version="1" fragment="single">MENPVPKSCAVQYDAGAERIDTSLIEGKSATTTTTTAATTSTSDTGTKSSSKLKMAKEIRIWMVLAALFIAISIALSIYLIYVKKTERTDVHVEEKPPGETEVLSMYPAFFRTARQQEEFAAQYERMIQPWKIRKAPLDSRKPTQTCSFRCFNQTVQTGYPSLVKRDTGGRKYHRAVRATTHKLFKRQTTQSPDIHHACCISTPNYIDPTNALAIWGSNVTVIQYGAWRQYFPIEDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TLC1</accession>
    <name>A0A433TLC1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_009915</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000291">
        <property type="protein sequence ID" value="RUS82325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TLC1"/>
    <dbReference type="STRING" id="188477.A0A433TLC1"/>
    <dbReference type="OrthoDB" id="6159913at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000013">
        <property type="entry name" value="Membrane frizzled-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251:SF37">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019109967" description="CUB domain-containing protein" evidence="4">
        <location>
            <begin position="28"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="28"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS82325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="172" mass="19114" checksum="81DE220A0A218237" modified="2019-05-08" version="1">MEFRYQSDMVRVAFLVIKLCLIMCCSGCNVKLRGDSGALESPKHPDHHGSQVRCEWSISTSPGTKVRLTFTDLELKDVNGCNVDYIQIRNGNNKDAPLLAKLCGEKKSLPPGPITASGNNMFIEFSTDRRTPLGGFQAVWAAGNNTDNYWLFVLLFSVRDQHYIINPGVCLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TMW8</accession>
    <name>A0A433TMW8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_009323</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000266">
        <property type="protein sequence ID" value="RUS82900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TMW8"/>
    <dbReference type="STRING" id="188477.A0A433TMW8"/>
    <dbReference type="OrthoDB" id="5141738at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="369"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS82900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="562" mass="63674" checksum="0AE08914A53B0530" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TNC5</accession>
    <name>A0A433TNC5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_009125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000258">
        <property type="protein sequence ID" value="RUS83093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TNC5"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS83093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="150" mass="17542" checksum="A8250B0A5F31FC58" modified="2019-05-08" version="1">MKPWPTRNWQHRCWRTNLRDFRAKGTLAPRHLLGAPPGRSESRALRCHAPLGPRQQTRTSTTRCLTCFPATTMPKVQGRWIPRTVKAPWLLKGRRVPPTWSTSFVTMRWPISVMTLLTDFHSLRRRRGRGRRRRIPSLLLSAPMTGRKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TP96</accession>
    <name>A0A433TP96_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_008853</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000245">
        <property type="protein sequence ID" value="RUS83387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TP96"/>
    <dbReference type="OrthoDB" id="6285980at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="2">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS83387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="67" mass="7543" checksum="8C134F6881040898" modified="2019-05-08" version="1">MRDTLLVCPDFSAGLCASPYCKKVHLSEDYVEVSNGSVTVCRDFATRQTCKRSRCKFYHIPVDLPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TQD4</accession>
    <name>A0A433TQD4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Endothelin-converting enzyme 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_008492</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000232">
        <property type="protein sequence ID" value="RUS83741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TQD4"/>
    <dbReference type="STRING" id="188477.A0A433TQD4"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000076">
        <property type="entry name" value="membrane metallo-endopeptidase-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="12">
        <location>
            <begin position="124"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="11">
        <location>
            <begin position="585"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS83741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="742" mass="84057" checksum="BF0DB0DF8488C60B" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TRL8</accession>
    <name>A0A433TRL8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_008044</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000214">
        <property type="protein sequence ID" value="RUS84204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TRL8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33426:SF30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33426">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS84204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="192" mass="21374" checksum="CE20A8FEA42F5081" modified="2019-05-08" version="1" fragment="single">RNVLLASAFRQGVWRDGHHPLAWSSNFTSMAWHKALLDGYTVLHGLTFVFCKVFGSEEALSTLFTLETIVQVMPSLMLNKVWPTREALAADVAGVGFDTTVGNNVCLQFIWTIEFFQAAWGKERENTGSEWTAILFHSLVNGHVALQLVLAVEGGLAELAGKRRLASVNEHVRFEVVLRFELLAAFLTLKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TTS7</accession>
    <name>A0A433TTS7_ELYCH</name>
    <protein>
        <recommendedName>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
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                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TW59</accession>
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            <fullName evidence="3">beta-N-acetylhexosaminidase</fullName>
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        <name type="scientific">Elysia chlorotica</name>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
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                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
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        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SMART" id="SM01081">
        <property type="entry name" value="CHB_HEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="Carbohydrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Chitobiase/beta-hexosaminidases N-terminal" evidence="10">
        <location>
            <begin position="55"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR625705-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS85813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="876" mass="99629" checksum="7BD792AB9D1AE92E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TW62</accession>
    <name>A0A433TW62_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_006496</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000160">
        <property type="protein sequence ID" value="RUS85782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TW62"/>
    <dbReference type="STRING" id="188477.A0A433TW62"/>
    <dbReference type="OrthoDB" id="6161227at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052065">
        <property type="entry name" value="Compl_asym_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906:SF21">
        <property type="entry name" value="SEMA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019184940" evidence="3">
        <location>
            <begin position="26"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS85782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="218" mass="24251" checksum="51ED5405E9D63B2B" modified="2019-05-08" version="1">MRVDWIKTGPYLVLLVTVWLCPSRAQLIELNSTECAQWTSWSPWSQVSPCAPACGPGTQTRQRQRPCPDQPSVTQFDVQTFACENPPVDGGPGEWGEWAESSSCQVYCGRGLAKAVRTRDCNNPAPSCGGRYCAKEDLVGRDYKECTNFPCGHICPGDLAEYVSQYSPVQGFYILCKERSGYLMRCPNMGDDWLDLRSTARLGYNDILAVCSGNYRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TWY4</accession>
    <name>A0A433TWY4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_006191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000152">
        <property type="protein sequence ID" value="RUS86037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TWY4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48209">
        <property type="entry name" value="AGL056WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48209:SF2">
        <property type="entry name" value="FI24008P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS86037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="255" mass="28951" checksum="1ADF5CF734997508" modified="2019-05-08" version="1">MIILDDDDDDDDDDDDDDDDDHDDDDDDDDDDDDDDDDDDNDDNDEDDDDDDDDDDDDDDDDDDDTFLCLLLVVNSLRHVRELTLGVQPERQITGAEEKKFSIQVLETPPISTMRHDKWTLRSVVRYVHLSWFHFEPDPGFQVCQTPSCLTSSFTANKYSDHALAIDKSLPNKCFKTDLVIRSTLEFGQEIIKLQMPSKSSGYHSLERSTEAACRSHRFTTLQLSGPSESCPDPGTGIAMAWRQDSEKVPDSQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TX84</accession>
    <name>A0A433TX84_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_006046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000147">
        <property type="protein sequence ID" value="RUS86200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TX84"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS86200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="212" mass="24112" checksum="8B39589A774759E4" modified="2019-05-08" version="1">MVQILQKMRLRQERVKIDDDDDDDDDDDDDDDDDDDDDDDDDDDDSDDDDDDDDDDDDDDDDDDDDDDGGDTMTPVSAGHIKLTLTQPVESAIARARTGPFASEADVLPQGHCTPQKWRKLRSDNDEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDELAQMIQRSSLNREIRGLNSMIDQKFIFPTLSPFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TY80</accession>
    <name>A0A433TY80_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_005693</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000135">
        <property type="protein sequence ID" value="RUS86554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TY80"/>
    <dbReference type="STRING" id="188477.A0A433TY80"/>
    <dbReference type="OrthoDB" id="10258888at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051059">
        <property type="term" value="F:NF-kappaB binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071356">
        <property type="term" value="P:cellular response to tumor necrosis factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051070">
        <property type="entry name" value="NF-kappa-B_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680:SF3">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR CACTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="100"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="189"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS86554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="250" mass="26968" checksum="317714521961D27D" modified="2019-05-08" version="1" fragment="single">TALHWSCWYNNEPLSTLLLDSGADPSREDGAGYNCLHMSASTGALDCVRLVLGRRKELLNRRGGENGVTPLLAAVQKGDSSVVAALVTSGADVNCQEETSKRTPLHYALYTKKKDLFEYLLQHGADITKTDHRGTTIIHRCCTIQDAGFLKAVLSFGRSLPRKLSTHTALSAAHTTTPLGRALQMGDGEGATPVIVACQNGNLEQLTMLVEAGAPVSNKDKFQRCALHHCVENPATECAEYLLRAIPSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U0Q4</accession>
    <name>A0A433U0Q4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_004826</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000112">
        <property type="protein sequence ID" value="RUS87372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U0Q4"/>
    <dbReference type="STRING" id="188477.A0A433U0Q4"/>
    <dbReference type="OrthoDB" id="10063139at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000003">
        <property type="entry name" value="Protein CBG25708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000063">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF14">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="8">
        <location>
            <begin position="432"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="602"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="674"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="607"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="686"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="697"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS87372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="755" mass="85126" checksum="0612B911D90F23F2" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U0W7</accession>
    <name>A0A433U0W7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS15</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_004758</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000109">
        <property type="protein sequence ID" value="RUS87504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U0W7"/>
    <dbReference type="STRING" id="188477.A0A433U0W7"/>
    <dbReference type="OrthoDB" id="623277at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.10:FF:000003">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.130:FF:000001">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_A">
        <property type="entry name" value="Ribosomal_uS15_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023029">
        <property type="entry name" value="Ribosomal_uS15_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012606">
        <property type="entry name" value="Ribosomal_uS15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006331">
        <property type="entry name" value="PRK08561.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15P/S13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885:SF6">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08069">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01386">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS15 N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
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            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS87504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="151" mass="17212" checksum="62DFA7927B8A4492" modified="2019-05-08" version="1">MGRMHNPGKGISKSALPYRRSVPVWLKLSAKDVEEQISKLANKGLKPSQIGVILRDSHGVAQVRFITGNKILRIMKKLGHGTDLPEDLYGLIKKAVNIRKHLERSRKDKDSKYRLILVESRIHRLARYYKRKKVLAPTWKYESSTASALVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U220</accession>
    <name>A0A433U220_ELYCH</name>
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        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_004315</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000097">
        <property type="protein sequence ID" value="RUS87899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A433U220"/>
    <dbReference type="OrthoDB" id="6414306at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
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    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF66">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21549">
        <property type="entry name" value="PRDM2_PR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
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            <end position="142"/>
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        </location>
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        <location>
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    <feature type="region of interest" description="Disordered" evidence="10">
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        </location>
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            <begin position="1412"/>
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        </location>
    </feature>
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        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="347"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
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    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
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    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="2667"/>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="2703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS87899.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="2703" mass="300368" checksum="DD3E8B98C272CF77" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U2A7</accession>
    <name>A0A433U2A7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_004242</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0239 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000095">
        <property type="protein sequence ID" value="RUS87964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10040809at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="UPF0239"/>
    </dbReference>
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        <property type="entry name" value="MANNOSIDASE, BETA A, LYSOSOMAL-LIKE, MANBAL PROTEIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR14409:SF0">
        <property type="entry name" value="PROTEIN MANBAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06783">
        <property type="entry name" value="UPF0239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="90"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS87964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="119" mass="13463" checksum="707916A02A53CE79" modified="2019-05-08" version="1" fragment="single">GSTAATPTRTAVNTNFNGGCEDPWHWKLDSRFYLKVNMAIVLEEPTFYENVLNYALYAGAVFQLLCIFAAITISQSPNEKEEEEEAAIKLQTSSSHQASRNRPQETASRRGKKEKKKHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U3H6</accession>
    <name>A0A433U3H6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_003837</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000084">
        <property type="protein sequence ID" value="RUS88381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U3H6"/>
    <dbReference type="STRING" id="188477.A0A433U3H6"/>
    <dbReference type="OrthoDB" id="7813104at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042719">
        <property type="term" value="C:mitochondrial intermembrane space chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.810:FF:000001">
        <property type="entry name" value="mitochondrial import inner membrane translocase subunit TIM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="12">
        <location>
            <begin position="24"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS88381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="95" mass="10776" checksum="57A4A69C9839F9E1" modified="2019-05-08" version="1">MDFSSGLPPGGKMDSASKEQLMSQVKQQIALANAQELLQKMSEKCYKKCISKPGTTLDNSEQKCIAMCMDRYMDTWNLVSRVYGQRLQRESSRMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U4C1</accession>
    <name>A0A433U4C1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Delta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EGW08_003567</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">EC2010</strain>
            <tissue evidence="17">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Putative Notch ligand involved in the mediation of Notch signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Membrane</location>
            <topology evidence="1 14">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000076">
        <property type="protein sequence ID" value="RUS88672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U4C1"/>
    <dbReference type="STRING" id="188477.A0A433U4C1"/>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000018">
        <property type="entry name" value="Delta-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.140:FF:000001">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000255">
        <property type="entry name" value="Sushi, nidogen and EGF-like domains 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001774">
        <property type="entry name" value="DSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049:SF22">
        <property type="entry name" value="DROSOPHILA CRUMBS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01414">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21700">
        <property type="entry name" value="EGF_DL_JAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 14" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0221">Differentiation</keyword>
    <keyword evidence="10 12 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 12 14" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="DSL" evidence="16">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="102"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="141"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="184"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="234"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="6"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU280815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RUS88672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="269" mass="28642" checksum="49ECD4FF1C61A284" modified="2019-05-08" version="1" fragment="single">SCTRFCRARDDYLGHFTCTATGQQVCKDGWQGLECSQAICSSRCMATRATCPAPNTCVCLPGWRGQHCDLCTPRPGCQHGTCSLPGQCACSHGWTGPLCDIEKEFCDLYQPCQNGGSCTHLGQHNYACACSTGYNGTHCEIPVCYVGFCHNEGTCSPHGKTKALCVCPEPFLGTHCLQRRSPGSTSPCSSSPCLYGGECFNIVQTTGASSSDEFSCKCLDGFSGDRCELDISIDTSLCAPSPCRNGGTCVEYDGEFLCVCADGFRGSLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U6V5</accession>
    <name>A0A433U6V5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_002719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000053">
        <property type="protein sequence ID" value="RUS89531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U6V5"/>
    <dbReference type="STRING" id="188477.A0A433U6V5"/>
    <dbReference type="OrthoDB" id="6095583at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS89531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="483" mass="52881" checksum="B1C05D27733901BF" modified="2019-05-08" version="1">MSTENGTKQSASCDKVHNLCTDCTLLRCESGSASATCYSCTSKPNCCTLASICEQTCPPKINLCAGFDKKYTPKGDLANMCEPCGQPPSGLAKYEQLLFDLQCPVAARYTSPNRCSSKCSPPVCPTSPAFYALRRAYLLSSDVCVPQCSPKCSPSPRCSLTCIPECCSPSSAACCPEPPPCCPKPPLCPFDLLPPRCPRCCEVVYPKPSPCNPCQPCNPFCPPQWSPRCIPQCPPQCSPQCSPSCVPQCRPLCSPPCPPQCPPQCPPQCSPRCIPQCSPQCPPQCPPQCSPRCIPQCSPQCPPQCPQPCYPQCSPRCKPCCVPQCPQGSCPAPCENHYCCPEVECQLPKGFYEFFTGNGTWDTYGVRIKWTDPAAPGTITIWRDRAVLLKLCVEVKQSCGLGPEDITANLWTNMQTMCNPCGTWKEMPMLYQCDSSSQGEFGIYRYVYTVSLTPLVDDTFKLSFNITWRDILIWANNMLECCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U8T3</accession>
    <name>A0A433U8T3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_001987</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000037">
        <property type="protein sequence ID" value="RUS90206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U8T3"/>
    <dbReference type="STRING" id="188477.A0A433U8T3"/>
    <dbReference type="OrthoDB" id="420380at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF244">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE SUBUNIT ALPHA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="9">
        <location>
            <begin position="223"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS90206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="364" mass="41191" checksum="FF048B68E26DC689" modified="2019-05-08" version="1" fragment="single">MLENFHRSVTEAGIAFEAEDGDLSGSALSLLRLQRVYGLKAFDMAQGDYLGHKGPALSPVDAYEIGQVAFMVSRLNDSLEWLNASLRLMSNLPAQSGIKLSSTTVKALMGRVHLYGGSYDIAQRLYDEVKVTDPHGGDTVELGKELVERPTPKLQEYQDYRNLSRLCSLENRIHVPNPSHPSMVCRYRPGLLPYYRFKEEIISERPFASVIYNFTSDAEAETFKDRVKNRTVNYGLGGHYSVHLDAFEDKRTIEDRRKGPGNRIATLLLYLSDVTRGGSTVFTKADIAVPPIKNMALFWYNYRPDHHLDYLTYHAGCPVVIGHKWIANKWVWTAGNTFRRRCALSPHASQLDIEADMRNSYLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U989</accession>
    <name>A0A433U989_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_001864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000034">
        <property type="protein sequence ID" value="RUS90369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U989"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS90369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="183" mass="20206" checksum="4E16017AEF6895B1" modified="2019-05-08" version="1">MVFSGSNLSRQEEEIIIIIIIIIIIIIIIIITITITLIEICSPGVVFPDLLLACRTPPDVKMNEMTSQKHYCYYNVHTRIPHSSKVQHERDDTVFCIGNGEIALAVEGLQFELAMFWPDGPHKTQVKAPRSLTHNPNKFCVTVVSSDFSPSGNGGCVVTTNVSLPFISFFLVALVCVFDVVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UA79</accession>
    <name>A0A433UA79_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pyroglutamyl-peptidase I</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_001522</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000026">
        <property type="protein sequence ID" value="RUS90718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UA79"/>
    <dbReference type="OrthoDB" id="407146at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016920">
        <property type="term" value="F:pyroglutamyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00501">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.20:FF:000008">
        <property type="entry name" value="Pyroglutamyl-peptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.20">
        <property type="entry name" value="Peptidase C15, pyroglutamyl peptidase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000816">
        <property type="entry name" value="Peptidase_C15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016125">
        <property type="entry name" value="Peptidase_C15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036440">
        <property type="entry name" value="Peptidase_C15-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402">
        <property type="entry name" value="PROTEASE FAMILY C15 PYROGLUTAMYL-PEPTIDASE I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402:SF1">
        <property type="entry name" value="PYROGLUTAMYL-PEPTIDASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01470">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00706">
        <property type="entry name" value="PYROGLUPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53182">
        <property type="entry name" value="Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS90718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="26705" checksum="540805B58391FB65" modified="2019-05-08" version="1" fragment="single">KTEISILGGLDGLLFLCEVCVCPHQRLIESLINQPAVMPSGNRCIVVTGYGPFRGHTVNASWVAVQELKSLGLDDNTVELHVYEIPVSYDVVKRTIPGLWEKHKPDLMVHVGVSGMASELTLEQQAHNDGYDRFDVDGQVPHTKMCVDGSCHNVIESGLNMSLVCAEVNNICEIKAKAVVSHDPGRYLCDFIYCLSLHINKKRTAFIHVPPLNAPYNASELAQGLRAAIKSMLNQLSSPSSSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UBH7</accession>
    <name>A0A433UBH7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_001001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000016">
        <property type="protein sequence ID" value="RUS91195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UBH7"/>
    <dbReference type="STRING" id="188477.A0A433UBH7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655:SF0">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS91195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="185" mass="21260" checksum="BDD8332EEFD197B6" modified="2019-05-08" version="1">MDFYLSRQLHDDNRFRRQGQEKRSLLKTPPTQEEKEHLHDMFLHTKKFTALSAKRSHLPGHCVWMKDTALRFVITCYPEIVHTSGSEVQVYVSAEKSNDGEMTKDFHFTFDSGGTNLRSGIPTAYSDGLRFVNGPRWSQQRRLLVKGGARGTIQLVYSAAKMVTRWRHRLSLVEIRPITVAACLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UC17</accession>
    <name>A0A433UC17_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_000918</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000014">
        <property type="protein sequence ID" value="RUS91304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UC17"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS91304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="106" mass="11553" checksum="9352624C20FC7334" modified="2019-05-08" version="1" fragment="single">GAHSPCDSPVGGHDKDRSHVGFQRSVQEGEALDVQHVHFQGLTHPWDYLGLALLAPLGDLGVDLLAHFRLDLASVAGEQREETLRAGVDHVDLVKRDGVHDLFAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UCQ0</accession>
    <name>A0A433UCQ0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ras-related protein Rab</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_000724</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000010">
        <property type="protein sequence ID" value="RUS91503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UCQ0"/>
    <dbReference type="STRING" id="188477.A0A433UCQ0"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045335">
        <property type="term" value="C:phagocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090385">
        <property type="term" value="P:phagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF42">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-7L1-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS91503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="20481" checksum="1EE099DCA4D1168A" modified="2019-05-08" version="1">MTVLRPGSWRHYLKLQFWDIAGQERFPLLTRAYYRFVRGCIVMFDITRPETFQRAMMWKRSLDLNTQTDSGGKVPCILVANKADLKNHAVTYSEVEALCQACGFSEWTMTSVKDGSMVKETVSYLLDVILQRSSVEYEPSEFDLVDHEVIQLQQDHSQRVKGAGPGLAGSCCSSAGFSLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z3Y9</accession>
    <name>A0A3S0Z3Y9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_022085</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001479">
        <property type="protein sequence ID" value="RUS70153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z3Y9"/>
    <dbReference type="STRING" id="188477.A0A3S0Z3Y9"/>
    <dbReference type="OrthoDB" id="1894652at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22209">
        <property type="entry name" value="EMC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21397">
        <property type="entry name" value="CHROMATIN COMPLEXES SUBUNIT BAP18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21397:SF4">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21203">
        <property type="entry name" value="ECM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS70153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="231" mass="25074" checksum="D3E43D26485A05A8" modified="2019-04-10" version="1">MATSIMISSISWLICLNCVFTAGVLLDDEFEGSRTLGLEHSFSSGKPEFTKRGTVVIQSLKGNKAQFTPASSMSEADIDSLKELAKKDGLYRVRIPIKDGDGPTFVSSATRACAIVESGLQDEITVNFDQSGEVLGVSIRGLVPACSGVDVPHSNLTAWKTSVEVYTTVSGPSPDTQTYIDKMKRDEQEKIKNQDGDNRSFLAKYWMYIVPVVIMMVIMSSADQQGQGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z4N4</accession>
    <name>A0A3S0Z4N4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_021630</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001370">
        <property type="protein sequence ID" value="RUS70610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z4N4"/>
    <dbReference type="STRING" id="188477.A0A3S0Z4N4"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243:SF4">
        <property type="entry name" value="CATIONIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243">
        <property type="entry name" value="INNER MEMBRANE TRANSPORTER YGJI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="7">
        <location>
            <begin position="7"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS70610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="253" mass="26053" checksum="003EBF96292BEEF7" modified="2019-04-10" version="1" fragment="single">CLTTFDVVSLGVGSSCGCGMYLTTGIVASRLAGPAGVFSFLLAGFASMLTGGCFHFAKLSSIFPNTSGSAYMYTRATVGEFLAFIIGWGLVGEVWGISRGILCMGVICVCTISWGLVGEVWGISRGILFDPVAGIIVLGLTAVLASGVELSAKVNNLLNLVNLVVLATFISASLALGDFSNLTRGRRVRGFFPFGTAGVVPVAYFAFVGFDGLAATGAECKTPARSIPAGILGSIAINTVAYISVVLMLTMDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZL32</accession>
    <name>A0A3S0ZL32_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_014855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000585">
        <property type="protein sequence ID" value="RUS77375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZL32"/>
    <dbReference type="STRING" id="188477.A0A3S0ZL32"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS77375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="481" mass="53787" checksum="4550A53C2D87A62E" modified="2019-04-10" version="1">MKTEATKPKMKKRNTRIMKKKKKKKKKKKKKKKKKKKKKKKKKKKKEKKNKNKNKNKNKNNVRKSAHKTQKLLGDVWKKRSRWCSEEKWKSFDGTICMKMLTFNKMPPHGKCIGRLFVQSVLLSMALTFNSLYRCFALLPIFPIPLLCAVPHLPYTAALPLLPIFPIPLLCAVPHLPYTAALPLLSIFPIPLLCAVAHLPCTAVSRCCPSSLYRCFALLPIFPIPLLYRCSTAVAHLPYTAALPLLPIFHIPLLYRCCPSSIYRCFALLPIFHVPLLCAVAHLPCTATSRCCPSSLYRYLALLPIFPIPLLCAIAHLPYTAALRCCPSPLYSCLALLPIFPIPLLCAVAHLPCTAASRCCPSSLYRCYALLPIFPIPLLCAVAHLPYTAALPLLYRCCPSSIYRCSTAVAHLPCTATSRCCPSSLYSCFALLPIFPIPLLCTVAHLPYTAVSRCCPSSLYRCFAMLPISPIQLLCAVAYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZLA5</accession>
    <name>A0A3S0ZLA5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_014748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000576">
        <property type="protein sequence ID" value="RUS77501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZLA5"/>
    <dbReference type="OrthoDB" id="10544128at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS77501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="291" mass="31918" checksum="C36494730075A3E9" modified="2019-04-10" version="1">MGDQTDSQKEEGIVDVYISSPSLSTPYQPQSREPALSSKAKSMDSVCSLTLGDWINKSCNKPSSFALKAQLQLGGVARLRVANLVEDLSHVIDKTDNAEGLKSAVSCESLRTLRDWLLPDMDELFYMAQASRCNAPNATKNHRIIIIIIIIIIIIIIITIIITIIIIIIIIIIIIIIIIIIIIIIIIIIIIIITITTIIIISLSSSAFSNKSTTIIVISIIIIIIIVIIIIIIIIIIIIIIIIIIIITITTIIIISLSSSAFSNKSQFTVIPCRLIYGDAVVDGLSSRFQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZLD7</accession>
    <name>A0A3S0ZLD7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_014677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000571">
        <property type="protein sequence ID" value="RUS77573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZLD7"/>
    <dbReference type="STRING" id="188477.A0A3S0ZLD7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS77573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="218" mass="23561" checksum="19D4BDC594BF9B4D" modified="2019-04-10" version="1">MPAGQREKLTKEAGIWGYIMPAGQREKPTKEAGIWGYIMPAGQREKPTKEAGIGGYIMPAGQREKPTKEAGIWGNIMPAGQREKPTKEAGIGGYIMPAGQREKPTKEAGIGGNIMPAGQREKPTKEAGIWGNIMPAGQREKLTKEAGIWGYIMPAGQREKPTKEAGIWGYIMPAGQREKPTKEAGIGGTSCLLDRERNQLRKPASGARATRQAANNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZM93</accession>
    <name>A0A3S0ZM93_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">inx</name>
        <name evidence="10" type="ORF">EGW08_021564</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001356">
        <property type="protein sequence ID" value="RUS70674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZM93"/>
    <dbReference type="STRING" id="188477.A0A3S0ZM93"/>
    <dbReference type="OrthoDB" id="5867527at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF36">
        <property type="entry name" value="INNEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS70674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="418" mass="47824" checksum="72AF55095605E8AE" modified="2019-04-10" version="1" fragment="single">DILTGSSLNRVNDEDLCSQINYVWTATIVAVIGLLVTMVQYVGEPIQCLCPAQLTEAQCNYTKALCWVKHNYFVHEENPIALKEEDRYELTIAYYPWIPWILFAMAAMLNIPNILWQTFAPGSGLDLKKFIFQADTHENLDNLGKILMLWLGKRKQRKDSNVVEKFQKTVGSCGFFWCGRFERSYLCGLLLFTKFSYLLVTVGCFFVLGIFIEESMLSYGFDVVDDYLHGVSYELNRFPVYTICDIKVRQLANIQTYSFQCVLPLNMYNQKIFLVLWFWLVLVSLVNAYSLAKWALYLLSYSSRRRFVKMYVMMLHHLLPRKRARLRVDPNANSIPANGYVGDAGPDSEITLADNDAQLLSLPEGAGVDAHADTSGVSRLRRMRVSFSDDASTGLRPRSGIRRWIPRKPAVRSSIEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZMQ0</accession>
    <name>A0A3S0ZMQ0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="9">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_021230</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="9"/>
    <dbReference type="EMBL" id="RQTK01001288">
        <property type="protein sequence ID" value="RUS71008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZMQ0"/>
    <dbReference type="OrthoDB" id="6380564at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF54">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS71008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="444" mass="50895" checksum="536176CEEE70EB99" modified="2019-04-10" version="1">MPSWRRGVGVARVLCKGCCRQPLLFAGAALFLVFVYVFAVGSHSWNHNHVLVDSSNIDIAAIIREKHMDVQNSTTTTTEATTLPTVQQLDDDASLTFEAAQKIRLERIQKACAAPDRPIGFVNTLIGTARGNLTYCMTPRSANTFWLQMLRYSQRDFVDEVPQSPLDLDTRQVRTRPFIRTRRYNWKVLSEVEKDAVLNSKIFMSVQDPYWRLWTTYLTALTLPDLWGSVGAKIEAKRPPVRDPLKRKPPLPCGDTVTFEEFVQYVLKAFEPDLQPIHHQCDPCTLPLSYVIKASTAKRDNRYILSHLNLTWALELSDVEAELRQRYIKTMIMENFDRLHDIRIQRCVTFGDLARRLWHSFVLQGLLPDTAAMPEGIDDLHQTVFAERVAMLAQETAGEIPDRRKYMVAAFKHLSPDTLSAVRDKFMMDFQLFGYDPEPPEIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZND2</accession>
    <name>A0A3S0ZND2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coenzyme Q-binding protein COQ10 START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_020778</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with coenzyme Q.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the COQ10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001207">
        <property type="protein sequence ID" value="RUS71463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZND2"/>
    <dbReference type="STRING" id="188477.A0A3S0ZND2"/>
    <dbReference type="OrthoDB" id="292693at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07813">
        <property type="entry name" value="COQ10p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044996">
        <property type="entry name" value="COQ10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901:SF10">
        <property type="entry name" value="COENZYME Q-BINDING PROTEIN COQ10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901">
        <property type="entry name" value="SPERM PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coenzyme Q-binding protein COQ10 START" evidence="4">
        <location>
            <begin position="97"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS71463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="205" mass="23508" checksum="26D0CB04A8070B13" modified="2019-04-10" version="1">MAGLGYKSVWFRGLKPRSASFFKPTENKTLASGLRHIHKLSRFHPTVTQLFPHQSTLLKLLPSNRTHNSRFLFKLPNLNPLAPASKRKQYAERRLLGYTMDEMYVIVADVGSYKEFIPWCSNSSVFDVRPSSFKAKLEIGFPPLQEKYTSSIKLVRPNLVHSECTDGKLFTQLLTIWKFSPGLPGNPRTCTLDFSVRYIHFCLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZNK0</accession>
    <name>A0A3S0ZNK0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-dependent kinases regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_010195</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the CKS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000307">
        <property type="protein sequence ID" value="RUS82039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZNK0"/>
    <dbReference type="STRING" id="188477.A0A3S0ZNK0"/>
    <dbReference type="OrthoDB" id="440676at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.170.10">
        <property type="entry name" value="Cyclin-dependent kinase, regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000789">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036858">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01111">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01084">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55637">
        <property type="entry name" value="Cell cycle regulatory proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00945">
        <property type="entry name" value="CKS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU311113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS82039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="129" mass="14882" checksum="498B4BF610DE7C1C" modified="2019-04-10" version="1">MLGIEKGDLEARVRKAIPKEDMAALQKQIFYSDKYTDDEFEYRQGRHAACLKCPLTGSQTAFTPFSALQHVMLPKEIAKLVPKTHLMTEHEWRSIGVQQSQGWVHFLRHDPEPHILLFRRRLPGAMITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZPM1</accession>
    <name>A0A3S0ZPM1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_012413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0585 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000426">
        <property type="protein sequence ID" value="RUS79814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZPM1"/>
    <dbReference type="STRING" id="188477.A0A3S0ZPM1"/>
    <dbReference type="OrthoDB" id="10258744at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010342">
        <property type="entry name" value="DUF938"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20974">
        <property type="entry name" value="UPF0585 PROTEIN CG18661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20974:SF0">
        <property type="entry name" value="UPF0585 PROTEIN CG18661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06080">
        <property type="entry name" value="DUF938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS79814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="29498" checksum="226B203C3A78F6FE" modified="2019-04-10" version="1">MTKHLRCLFNRLAFSVKHTVISKPRSTSNKEYQIGKEMSAEQFSKVQESYIPSDRMIVVGPGERNKQPILDVLLKYLPPRDKEGFVLEVASGPGQHVCHFASRCPHITWQPTDLDENYFKSINAHIEHNGLKNVLPPLHVDISKPLSEWATPELTAGSCDLVVNVNMAHISPWKATVGLFKASGEVLKPGGILCMYGPFKVDGVLKPESNVNFDQHLRSQDSSWGIRDTADLDKLAKDNKMRRENMVDMPANNFCAIFRKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZPQ5</accession>
    <name>A0A3S0ZPQ5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_012362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000423">
        <property type="protein sequence ID" value="RUS79884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZPQ5"/>
    <dbReference type="OrthoDB" id="6134782at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.340">
        <property type="entry name" value="Rel homology domain (RHD), DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011539">
        <property type="entry name" value="RHD_DNA_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037059">
        <property type="entry name" value="RHD_DNA_bind_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50254">
        <property type="entry name" value="REL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHD" evidence="2">
        <location>
            <begin position="67"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="698"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="703"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS79884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="775" mass="85595" checksum="2C4F8674BF62DD85" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZR18</accession>
    <name>A0A3S0ZR18_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_018953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000955">
        <property type="protein sequence ID" value="RUS73280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZR18"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS73280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="253" mass="28736" checksum="9070AB30A7923F2E" modified="2019-04-10" version="1">MLSYFCNSGVYLVWANLESRDKLLTVLDAATQIECWGTPTPVSAQHTSLTTVEDQNRGIEPSTLRQDTQRSTTEASWPLGDELAQMVERWSPDWNFRSSNARWEEEDADENDNDDDGNDADDGDDDHHNNDDAIMDDDHGNNDDAIMDDDHDNNDDAIMDDDHDNDDDAIMDDDHDNDDHIVDDDHDNDDDDDTVDDDHDNDDDVVDDDHDNNDDIVDDEPNNDDDIVDDEPDNDDDVIMMAVTMIMLRMISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZUF4</accession>
    <name>A0A3S0ZUF4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_009198</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000260">
        <property type="protein sequence ID" value="RUS83059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZUF4"/>
    <dbReference type="STRING" id="188477.A0A3S0ZUF4"/>
    <dbReference type="OrthoDB" id="270970at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21669">
        <property type="entry name" value="SMP_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052455">
        <property type="entry name" value="Tricalbin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980">
        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980:SF2">
        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="9">
        <location>
            <begin position="124"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="473"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="656"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="814"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="902"/>
            <end position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS83059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1078" mass="119675" checksum="C2F9A6B4287D80B3" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZVF3</accession>
    <name>A0A3S0ZVF3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_016042</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000681">
        <property type="protein sequence ID" value="RUS76198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZVF3"/>
    <dbReference type="STRING" id="188477.A0A3S0ZVF3"/>
    <dbReference type="OrthoDB" id="7489468at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS76198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="150" mass="18261" checksum="7BEE360BF26E12D0" modified="2019-04-10" version="1" fragment="single">YKLTNYKLSTYKLTIYKIQTSNLQTTNLQLTNYKLTTYKLQTYKLQTINLQLTNYKLTTYKLQTYNLQTTNLQPKNYKPTTYNLQTYNLQTTNLQLKNYKRTNYKLQTYNLQTTNLQFTNYKPTTYKLQTYKLQTYKLQTYKLQTYNLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZVN1</accession>
    <name>A0A3S0ZVN1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Stabilizer of axonemal microtubules 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_015884</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM154 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000669">
        <property type="protein sequence ID" value="RUS76354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZVN1"/>
    <dbReference type="STRING" id="188477.A0A3S0ZVN1"/>
    <dbReference type="OrthoDB" id="365640at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005879">
        <property type="term" value="C:axonemal microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033336">
        <property type="entry name" value="SAXO1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31516">
        <property type="entry name" value="STABILIZER OF AXONEMAL MICROTUBULES 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31516:SF17">
        <property type="entry name" value="STABILIZER OF AXONEMAL MICROTUBULES 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05217">
        <property type="entry name" value="SAXO1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS76354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="53895" checksum="EA241BF0616B8322" modified="2019-04-10" version="1">MGKRCVCEICTCGRHHCPHRPWRPGGDFGPCLVTSYNTAYKQHPIQLRESCKPEASAMRSEDPLSDKTTFRTDYVKHPMDKPYCHPHEQYKRPSGEIDTLTSYHRDYTEKHAPPAPMIKREGQRQLPARFEGEPTYKVDYRRWPIEKHHAKVPEGWAPPTQPFEGESTFTRDFRKYNERPRESMRPSEATQLSNSPFDGNTGYRADYIRHPVQSREQREKEKYKGPSAPFDGMSTFTRDYTKKQGSKTESCRPNAEAYQSDAPLDDLTTFKNDYRRWNGERPHVHLPEQYKQPEGDMDHNTTHRIQYKPHPLQKVAMMKPGEGRVMIPGEFEGLTNYKADYKPWGIHREVPKAREGWVPSNVPFEGQATYKSHYTAHNIAPTRSMKPDATAKASDAPFEDATMYRTEYTRKNADVCPAAILNSKSSSYTYVETDNRGHKQYIPVHERTTPLRRVSSAAPKIPAVMVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZX23</accession>
    <name>A0A3S0ZX23_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_014838</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="RQTK01000584">
        <property type="protein sequence ID" value="RUS77392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZX23"/>
    <dbReference type="STRING" id="188477.A0A3S0ZX23"/>
    <dbReference type="OrthoDB" id="302728at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="116"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS77392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="307" mass="35328" checksum="A0A50BE15288CC60" modified="2019-04-10" version="1">MQRRQATLKEKLSEHYRKRDFKAKKQTASTAGVVFFLCMLVTLVLEGLVVLLPRYYTSDDGSMASGYRLSQLLAVWLFLATAANWYNTYYDVANRVTKEMKAAHYPSSSETPPGWKNCPLCMLDAPPRSHHCSLCNYCILKRDHHCFVTGSCVGYHNQRTFVVFCIYTLISTTWAAFLQISYLNQDLPISTYWASFYFPLAGLWQYLAGAVPFLNFFILVHLCCTLVSFGLVVFFLFWQLVIIARGQTSFEAWKQISIYRRRAVLNNFQDVFGQLTNFLLCLVVPLRLPMPADGIKWVIEPKEEKGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZXJ2</accession>
    <name>A0A3S0ZXJ2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BAAT/Acyl-CoA thioester hydrolase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_006734</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000167">
        <property type="protein sequence ID" value="RUS85526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZXJ2"/>
    <dbReference type="STRING" id="188477.A0A3S0ZXJ2"/>
    <dbReference type="OrthoDB" id="6347013at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2240">
        <property type="entry name" value="Acyl-CoA thioester hydrolase/BAAT N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016662">
        <property type="entry name" value="Acyl-CoA_thioEstase_long-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014940">
        <property type="entry name" value="BAAT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006862">
        <property type="entry name" value="Thio_Ohase/aa_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042490">
        <property type="entry name" value="Thio_Ohase/BAAT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10824:SF4">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10824">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08840">
        <property type="entry name" value="BAAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04775">
        <property type="entry name" value="Bile_Hydr_Trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016521">
        <property type="entry name" value="Acyl-CoA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase" evidence="3">
        <location>
            <begin position="50"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="BAAT/Acyl-CoA thioester hydrolase C-terminal" evidence="4">
        <location>
            <begin position="257"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR016521-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS85526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="458" mass="50931" checksum="2EC9CE7838C14717" modified="2019-04-10" version="1">MQRLHTVVRHLASAAQSQKSYIQPNRLSSTAANTNNAPSIVAEPRAALYDEDVRISLHNFPPEAKVTLHGQVTQQYSKTVFASCGHYLSNKSGLIDLATDPSQGGTYFGVEPMGFLWSLQSAPGHPTDTRMTINVTDKPIVITLKAYLGHLNLEQIYTGKEGQEEEQVSHSVAQLDLERFSKARGVMRHEVEEGNVRGALYLPAGEGPFQGVIDMFGSSGGLTEYRSALLASRGFAALSLAFFKYKDLQEHMYDLKYEYFEESINWLTSHPKVASGGIGVIAVSKGVENALIMGAYSSKVAAVVAINGYCFATVGNYLRNNQVLQKAQNVDLEKIKVTEEGFDLREAMAEPTDIIPVWQGQAKYLLFESLDDYQTKPNAHKDLLDKCPEWKQRDIQVVQYEGAGHLLEPPYNPLCRSSINKGIGVKMKWGGRPREHAYAQLDAWRRTLEFFHQNIPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZXL8</accession>
    <name>A0A3S0ZXL8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glucosamine-6-phosphate isomerase</fullName>
            <ecNumber evidence="8">3.5.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glucosamine-6-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_003076</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12172"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:75989"/>
            <dbReference type="EC" id="3.5.99.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 8">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.6" evidence="8"/>
    <dbReference type="EMBL" id="RQTK01000063">
        <property type="protein sequence ID" value="RUS89197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZXL8"/>
    <dbReference type="STRING" id="188477.A0A3S0ZXL8"/>
    <dbReference type="OrthoDB" id="7663298at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006043">
        <property type="term" value="P:glucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01399">
        <property type="entry name" value="GlcN6P_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000004">
        <property type="entry name" value="Glucosamine-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018321">
        <property type="entry name" value="Glucosamine6P_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00502">
        <property type="entry name" value="nagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280:SF5">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01161">
        <property type="entry name" value="GLC_GALNAC_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="9">
        <location>
            <begin position="14"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS89197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="262" mass="29590" checksum="269AACE9646F1B51" modified="2019-04-10" version="1">MRLVIQDTYDDVSLWAAKYVKRRILDFNPSQDKFFTLGLPTGNTPIGMYRKLVEFFKDGSLSFKYVKTFNMDEYVDRISFMWNNFFKHIDIDPQNAHILDGNAKDLIAECNAFEEKITAAGGIRLFIGGIGPDGHIAFNEPGSSLVSRTRVKSLAQETILANARFFDNDLSQVPTQALTVGVGTVMDADEVMILITGAHKAFALHKAIEEGVSHMWTVSAFQQHPRTIFLCDEPATNELRVRTVKYFKGLMELHNKMLEEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A100</accession>
    <name>A0A3S1A100_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_004330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000097">
        <property type="protein sequence ID" value="RUS87914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A100"/>
    <dbReference type="OrthoDB" id="6515930at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="130"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS87914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="185" mass="20121" checksum="3D2F16FE0FDB9094" modified="2019-04-10" version="1" fragment="single">MAYGGTSGLQRVSNQTVEQLQNLTFPGWDTSEKGRQTLVYGMAVGTASLPQIRRVVLTGAENWKLFDTFSDLENLAHNLDNSNENIRTIGKEGKNADWKHDTDQSSVACSMTCSEHAQCLCSLTTGQTLCTCLPGYFGNGQHCTPCPKGSYKEDTSARRRCDSCPIHLGTRDEGATSAHLCKPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A1F1</accession>
    <name>A0A3S1A1F1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NtA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_000847</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000012">
        <property type="protein sequence ID" value="RUS91417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A1F1"/>
    <dbReference type="STRING" id="188477.A0A3S1A1F1"/>
    <dbReference type="OrthoDB" id="382013at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043236">
        <property type="term" value="F:laminin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043113">
        <property type="term" value="P:receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004850">
        <property type="entry name" value="NtA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="TIMP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51121">
        <property type="entry name" value="NTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NtA" evidence="3">
        <location>
            <begin position="153"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="404"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="407"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS91417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="446" mass="49581" checksum="F3C177C4C3FF4048" modified="2019-04-10" version="1">MYYYYTCIHIGIIKFRLLQVYKGHEFLQNVTSAAPSANNDVYNISNFGSKAQCYADVEVGSRYILFLTLYDGRLSGQYDDLFGAAAAFNEENEQGILLRPAPAMTCTTSATSAARRSAMLTWRMRGGRASGRPYCLLTLVYICVHLTHISLSCVLLLNGWTPMSVRERAQLADISAMGLVLNTWAGPPSSGDDTYSAEFRLLQVYKGHEFLQNVTSAAPSANNDVYNISNFGSKAQCYADVEVGSRYILFLTLYDGRLSGQYDDLFGAAAAFNEENEQGILHYLQFRLLQVYKGHEFLQNVTSAAPSANNDVYNISNFGSKAQCYADVEVGSRYILFLTLYDGRLSGQYDDLFGAAAAFNEENEQAKSAGASLSGPALFWRAWIRSNGKFRFCQSSHLVLTAHENHGDDDDENHDDDDDDDDDDDDDDDDDDDDDDDDDEISEVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A1X2</accession>
    <name>A0A3S1A1X2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_011652</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000383">
        <property type="protein sequence ID" value="RUS80597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A1X2"/>
    <dbReference type="STRING" id="188477.A0A3S1A1X2"/>
    <dbReference type="OrthoDB" id="100006at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022343">
        <property type="entry name" value="GCR1-cAMP_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022340">
        <property type="entry name" value="GPCR_GCR1_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF43">
        <property type="entry name" value="CYCLIC AMP RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05462">
        <property type="entry name" value="Dicty_CAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02001">
        <property type="entry name" value="GCR1CAMPR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02000">
        <property type="entry name" value="GCR1PLANT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS80597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="35442" checksum="A74A4A8F553AAF7C" modified="2019-04-10" version="1">MSNSSCSGFSDKPHLCDVIIGVRKFSGSLSFVGCLFMIFIIWLFKRYVVFAQRLILYLSFAALLDSIAYLMSSDIDDGPMCNFQGWWLTFFDWMVLLCVSCLTFNLFMNVIKQTVTEKYEWLYIGICVIIPLIVSCLPFSKDRYGPAGAWCWIVEDIGWRIGIWYGPLFVIIVFMMVTYGYIIYSLSRKASSWEGTYDPDTERHHRLLKEDIKPLRVYPFIYLAVSIFPLINRIQNAFSPDNHVFILVLLSSISSPLHGALNAVVFGMDKETLHKLRPSEIKLAIQAKRAPKAVVQEYQPGSDRQALED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A1Z5</accession>
    <name>A0A3S1A1Z5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor 1-beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_003693</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalytic subunit of the guanine nucleotide exchange factor (GEF) (eEF1B subcomplex) of the eukaryotic elongation factor 1 complex (eEF1). Stimulates the exchange of GDP for GTP on elongation factor 1A (eEF1A), probably by displacing GDP from the nucleotide binding pocket in eEF1A.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">EF-1 is composed of 4 subunits: alpha, beta (alpha subunit of the eEF1B subcomplex), delta (beta subunit of the eEF1B subcomplex), and gamma (gamma subunit of the eEF1B subcomplex). Interacts with elongation factor EEF1A1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the EF-1-beta/EF-1-delta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000080">
        <property type="protein sequence ID" value="RUS88517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A1Z5"/>
    <dbReference type="STRING" id="188477.A0A3S1A1Z5"/>
    <dbReference type="OrthoDB" id="331763at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005853">
        <property type="term" value="C:eukaryotic translation elongation factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00292">
        <property type="entry name" value="EF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.60:FF:000001">
        <property type="entry name" value="Elongation factor 1-beta 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.130:FF:000001">
        <property type="entry name" value="Putative Elongation factor 1-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036219">
        <property type="entry name" value="eEF-1beta-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018940">
        <property type="entry name" value="EF-1_beta_acid_region_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049720">
        <property type="entry name" value="EF1B_bsu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014038">
        <property type="entry name" value="EF1B_bsu/dsu_GNE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001326">
        <property type="entry name" value="Transl_elong_EF1B_B/D_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595">
        <property type="entry name" value="EF-HAND AND COILED-COIL DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595:SF21">
        <property type="entry name" value="ELONGATION FACTOR 1-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10587">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00736">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00888">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54984">
        <property type="entry name" value="eEF-1beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00825">
        <property type="entry name" value="EF1BD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange" evidence="9">
        <location>
            <begin position="132"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="65"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00093529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS88517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="218" mass="23811" checksum="9F61A2EA1EB4769C" modified="2019-04-10" version="1">MGFGDLKSKAGLEALNAFLADRSYIEGYVPSQADNVVYGAVGKAPAASLAHALRWYNQMTSWQSKKDSLPGVKKPVASYGPSGGAAADDDDDDDLDDDDLFGSDDEDAKALREKRLAEYAAKKEKKPALIAKSNIILDVKPWEDTTDMKEMERLVRGIKADGLLWGASKLVPVGYGINKLQICCVVEDDKISTDFLEEEITAFEDHVQSMDIAAFNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A488</accession>
    <name>A0A3S1A488_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_001992</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000037">
        <property type="protein sequence ID" value="RUS90211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A488"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018577144" description="C-type lectin domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS90211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="55850" checksum="7EC971CCD29D33D2" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A871</accession>
    <name>A0A3S1A871_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_007167</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000183">
        <property type="protein sequence ID" value="RUS85073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A871"/>
    <dbReference type="STRING" id="188477.A0A3S1A871"/>
    <dbReference type="OrthoDB" id="6131926at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120025">
        <property type="term" value="C:plasma membrane bounded cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005112">
        <property type="term" value="F:Notch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000061">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000247">
        <property type="entry name" value="Delta/notch like EGF repeat containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916:SF9">
        <property type="entry name" value="NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 10" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="33"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="80"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="261"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="365"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="313"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="395"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS85073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="454" mass="48800" checksum="8023829223438117" modified="2019-04-10" version="1" fragment="single">MRPCANGGRCTDLPNDFQCECAPGFEGKDCSLMIDECRDSPCLHGGICQDQLADYTCTCPDGFWGKNCEKYAGMPVDVDPGKTSSTSANGRKNNTFTTRPPVQPTTAGNGDLSGQMDSSTGEQGDGESGLSMTQLLVIVCLGVGIPLILIIIAVTILLCRKRSYLQQRHTQQNLENMAREKERHYINNMNNKSSTTVSSNLSSPTSDANIFTTLPNSASNSSSIKISNEEQQDINKLKAKHLMLAGDCGLTSSYCSDMETPATTPGSGGGGGSALNQHVSGTGPHQRSHNTACPSGYLRDVVAITHKELRLLTPPTSSSSSILPSSSSACPVSEGVRRGSDCNLDFEKTYRRLDVDSLQADTKRPLSEYQRHHSQHKKALTAVSPPQVPLDYSAPDSTAPSNISTINTVSNRDSNTAAYSSPTTVYLGGYNNSLPSLTPQQQQLLQEQLKRHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A8X9</accession>
    <name>A0A3S1A8X9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_006544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000162">
        <property type="protein sequence ID" value="RUS85668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A8X9"/>
    <dbReference type="STRING" id="188477.A0A3S1A8X9"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS85668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="132" mass="13974" checksum="C231F00F7B2F6FA7" modified="2019-04-10" version="1" fragment="single">IKPSGTELTVVVRLIKPSGTELAVVVRLIKPSGTELTVVVRLIKPSGTELTVVVRLIKPSGTELAVVVRLIKPSGTELTVVVRLIKPSGTELTVVVRLIKPSGTELTVVVRLIKPSGTELAVVVRLMKPSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AAX8</accession>
    <name>A0A3S1AAX8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Selenocysteine-specific elongation factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Elongation factor sec</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Eukaryotic elongation factor, selenocysteine-tRNA-specific</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">EGW08_005162</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">EC2010</strain>
            <tissue evidence="20">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Translation factor required for the incorporation of the rare amino acid selenocysteine encoded by UGA codons. Replaces the eRF1-eRF3-GTP ternary complex for the insertion of selenocysteine directed by the UGA codon. Insertion of selenocysteine at UGA codons is mediated by SECISBP2 and EEFSEC: SECISBP2 (1) specifically binds the SECIS sequence once the 80S ribosome encounters an in-frame UGA codon and (2) contacts the RPS27A/eS31 of the 40S ribosome before ribosome stalling. (3) GTP-bound EEFSEC then delivers selenocysteinyl-tRNA(Sec) to the 80S ribosome and adopts a preaccommodated state conformation. (4) After GTP hydrolysis, EEFSEC dissociates from the assembly, selenocysteinyl-tRNA(Sec) accommodates, and peptide bond synthesis and selenoprotein elongation occur.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000120">
        <property type="protein sequence ID" value="RUS87086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AAX8"/>
    <dbReference type="STRING" id="188477.A0A3S1AAX8"/>
    <dbReference type="OrthoDB" id="2067at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001514">
        <property type="term" value="P:selenocysteine incorporation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04094">
        <property type="entry name" value="eSelB_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01889">
        <property type="entry name" value="SelB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03696">
        <property type="entry name" value="SelB_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000900">
        <property type="entry name" value="Eukaryotic elongation factor, selenocysteine-tRNA-specific"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000052">
        <property type="entry name" value="Selenocysteine-specific elongation factor EF-Sec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049394">
        <property type="entry name" value="eEFSec_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049393">
        <property type="entry name" value="eEFSec_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF11">
        <property type="entry name" value="SELENOCYSTEINE-SPECIFIC ELONGATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21131">
        <property type="entry name" value="eEFSec_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21208">
        <property type="entry name" value="euk_SelB_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="19">
        <location>
            <begin position="5"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="540"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="384"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="551"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00054716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00076506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00082387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RUS87086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="587" mass="63628" checksum="46358B13C42B6F07" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1ACL8</accession>
    <name>A0A3S1ACL8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_003826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000083">
        <property type="protein sequence ID" value="RUS88430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1ACL8"/>
    <dbReference type="OrthoDB" id="6122240at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS88430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="186" mass="20669" checksum="F6A4430AB17CF085" modified="2019-04-10" version="1" fragment="single">MNYLFYVGIILPTLITVCLFLVFIYCWFLQKARKEVLTRRYDPHGKMRRLGLSLEPPPPPDFCRFEVTVATPLSAQLSPAHYGEDNMAYCVSRSPSTDQQNQQQQQQQQQQHQLQQQPNPGRSLYHTYHDSGISAGGLAALSDSSERPDSQASHSPSTTDSEDSGFRGSHSANHAPLPPGSASLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AGF5</accession>
    <name>A0A3S1AGF5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_000925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000014">
        <property type="protein sequence ID" value="RUS91311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AGF5"/>
    <dbReference type="STRING" id="188477.A0A3S1AGF5"/>
    <dbReference type="OrthoDB" id="2015405at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050268">
        <property type="entry name" value="NADH-dep_flavin_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30466">
        <property type="entry name" value="FLAVIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30466:SF1">
        <property type="entry name" value="FMN REDUCTASE (NADH) RUTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="2">
        <location>
            <begin position="93"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS91311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="379" mass="43241" checksum="C13B9FC7C6979AD2" modified="2019-04-10" version="1">MAAGTLTISRHLTCSLKRSIQKIIKPASRTTTSQSWCRRSMQGSLPCKRFYASSSSVPPDDHHEVLLQRQRRREEAQKELVSAETSELFKLAMRKVPQQVIVVTTGLYQPESRSWLKRGVTCSTFSSVSFHPPIISLCLNQGSRMHNLLKSTKRFAVHILAQDQVRHGIHFSKPAKDDQCQFENIPHVQGEEGLPIILGSLACLLCDSHSYHGVGDHTVWYGTVTGVSMSETLQEPLIYFTRKFRSVGDEIFLKAFEDATLPFEDWTHQAHLRMAWNYIKEHGKEGAVPYIKLGIQKFNERNQDKVSTGYHETITMFFIHLVSDAIVQSVYANETFESFLTNNGHLLDKDILLQYYSIETLHQELARNKFIPPDKKPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AWA5</accession>
    <name>A0A3S1AWA5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_023251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001889">
        <property type="protein sequence ID" value="RUS68986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AWA5"/>
    <dbReference type="OrthoDB" id="6159772at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS68986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="378" mass="40548" checksum="66175F9A42371D30" modified="2019-04-10" version="1">MHRVVTTTMCSRNLAQTLDVGLQPFQINSFSRRPQTTEGIHLHASLGSTKKYGGAFASQTLSGDPGDPSSGSALSVETSDGWDVNNEWQGLVWCPSEVGAGERGIPSDRQTAKHGGDLLRKWEDTGGPERPGDTSRDGDGDAVLGPDNIPPSSPDKLETVGVSDKDTHEIEQVGGGTLDPGVTENTQEDSPLDIQYLKSILEQESDNFNIPSGYAVDVRGGDILSVVSEESGGHTHGHAHFRHRRDASSREFANLTLSGDVSDTETLVFVNEEKEEEKEENEEDDEDGDDWSPLVLTLSAPDLFQGDITLVLSAVDEFLSPGFVIQRVRGNSTWLEEGPVAGARGLDCYYTGRVLEASLDSNVAVSVCNGVVSPSSHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AYR4</accession>
    <name>A0A3S1AYR4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">U2A'/phosphoprotein 32 family A C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_021569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001357">
        <property type="protein sequence ID" value="RUS70670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AYR4"/>
    <dbReference type="STRING" id="188477.A0A3S1AYR4"/>
    <dbReference type="OrthoDB" id="10251250at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043313">
        <property type="entry name" value="LRMDA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46282">
        <property type="entry name" value="LEUCINE-RICH MELANOCYTE DIFFERENTIATION-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46282:SF1">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 72-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS70670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="24801" checksum="3FE46A7B1BB40410" modified="2019-04-10" version="1">MGAREESPTSVHLEVSLNNTRLSLAYSNLTDFPIDVIDRYGGSILELDLSNNKISDLRFLMELPKIQSLVLDHNHVTSQVKMPLCRDLHTLWVNHNRIQNLGFFLQTIAKNCPSLKILSMMNNEAAPSFFNGGTYQQYVDYRYFVVSSLPTLEVLDYTPITESEVREARRLYPSRMVNSDSETSLRRKLMKKRKKKSGEARQKEEDTELEMPSPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B052</accession>
    <name>A0A3S1B052_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_019382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001008">
        <property type="protein sequence ID" value="RUS72859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B052"/>
    <dbReference type="OrthoDB" id="5970946at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS72859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="113" mass="12346" checksum="2FA2CEDB26CA5B6E" modified="2019-04-10" version="1">MCRWGCAENNSTFMCKWCGTRYCRECLKGEYTGLMKESTTCAKCHQKKCQGQRVEAVLKEYLKNEESSGKRGAKSAGKSRSASAKRGKSASGKSSGKSKSKSGKAKSGKKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B205</accession>
    <name>A0A3S1B205_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_019162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000979">
        <property type="protein sequence ID" value="RUS73081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B205"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018534670" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS73081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="11820" checksum="FABB3E313D04CF7C" modified="2019-04-10" version="1" fragment="single">MSLLSLFHWFCRLFYCCSRTSFVFFCQRQSRLNPCTVILEPKFPSLSRCIHVHPFPCPVKRKHKQYPYLKKKKGILQTFCCSDGSTVAGAAIRERERERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B2W9</accession>
    <name>A0A3S1B2W9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Eukaryotic peptide chain release factor subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_017424</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic release factor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000796">
        <property type="protein sequence ID" value="RUS74815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B2W9"/>
    <dbReference type="STRING" id="188477.A0A3S1B2W9"/>
    <dbReference type="OrthoDB" id="10254527at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000009">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000001">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.960.10:FF:000001">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.960.10">
        <property type="entry name" value="eRF1 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024049">
        <property type="entry name" value="eRF1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03676">
        <property type="entry name" value="aRF1_eRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55481">
        <property type="entry name" value="N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="6">
        <location>
            <begin position="9"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS74815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="442" mass="49486" checksum="D91DE0A5EBD7B921" modified="2019-04-10" version="1">MASNGVDGESSADRNVEIWKIKKLIKSLEAARGNGTSMISLIIPPRDQIARVNKMLADEFGTASNIKSRVNRLSVLGAITSVQQRLKLYNKVPPNGLVIYCGTIITEEGKEKKVNIDFEPFRPINTSLYLCDNKFHTEALTALLADDNKFGFIVMDGNGALFGTLSGNTREVLHKFTVDLPKKHGRGGQSALRFARLRMEKRHNYVRKVAEVAVQLFISNDKPNISGLVLAGSADFKTELSQSDMFDPRLQAKIIKIVDVSYGGENGFNQAIELASDSLAHVKFIQEKKLIGRYFDEISQNTGKYVYGVTDTLTAMEMGAVDILIVWENLDIQRFVLKNHSSDEEKILHLTPDQEKDKTYFTDKETGVELELIDQMPLLEWFANNYKNFGATLEIITDRSQEGAQFVKGFGGIGGILRYQVDFQALDPTYDGLLDDFDLDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B5M4</accession>
    <name>A0A3S1B5M4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cathepsin B-like cysteine proteinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_015606</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Thiol protease. Has a role as a digestive enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000648">
        <property type="protein sequence ID" value="RUS76630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B5M4"/>
    <dbReference type="STRING" id="188477.A0A3S1B5M4"/>
    <dbReference type="OrthoDB" id="640249at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02620">
        <property type="entry name" value="Peptidase_C1A_CathepsinB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000031">
        <property type="entry name" value="Cathepsin B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012599">
        <property type="entry name" value="Propeptide_C1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08127">
        <property type="entry name" value="Propeptide_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018769910" description="Cathepsin B-like cysteine proteinase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="11">
        <location>
            <begin position="89"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS76630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="339" mass="37056" checksum="67FBBB53B2914D64" modified="2019-04-10" version="1">MHLAFVVSLVCLVAAACAASLDPAPLSDAQIQLINSDPTSTWKAGRNFRANQLEHVKGLLGVDMEANALYNQLHLDVLEDNDVISLEDLPENFDPREKWPNCSTIREIRDQANCGSCWAFGSVEAMSDRICVATGKNVHISSEDVLSCCQSCGNGCFGGYPTAAWTYYKRDGIVTGGQYGTKQGCQPYALPPCDHHVSGHLQNCSGPISPTPKCVATCIPEYKDTFKQDKHFGSKVYGVRGVENIMKELYTNGPVTAAFYVYSDFPAYKSGVYTHKHGQLLGGHAIKILGWGKEDGQDYWLVANSWNEDWGDKGLFKIAKGQNECNIESQIVAGLTKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B6P6</accession>
    <name>A0A3S1B6P6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_015953</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000675">
        <property type="protein sequence ID" value="RUS76281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S1B6P6"/>
    <dbReference type="OrthoDB" id="2325716at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051191">
        <property type="entry name" value="DCAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19860">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19860:SF18">
        <property type="entry name" value="DUF4062 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="376"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="869"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1455"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1694"/>
            <end position="1755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1814"/>
            <end position="1868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="869"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="912"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="930"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="946"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1697"/>
            <end position="1706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1852"/>
            <end position="1868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS76281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1931" mass="214282" checksum="7EF9C4F713EC560B" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BAV0</accession>
    <name>A0A3S1BAV0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_015992</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000678">
        <property type="protein sequence ID" value="RUS76249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S1BAV0"/>
    <dbReference type="OrthoDB" id="6147021at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48209">
        <property type="entry name" value="AGL056WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48209:SF2">
        <property type="entry name" value="FI24008P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS76249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="211" mass="24068" checksum="116F815224B5FB78" modified="2019-04-10" version="1">MVIQYDDDNDDDDDNDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDXXXXXXXXMMMMMMMMMMMMMVSRHPNSKSDKRDISSPEMNLPISSRNSHPATRDPMPLSPDVVDFSRNALPQVTALVHVFEDMGNSFTEENEDFLVLDSRDVVNPSPQTARVVEKTNQDQYDKFVIEGGIKRTASAFNNSFMSVLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BAX6</accession>
    <name>A0A3S1BAX6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Serine/threonine-protein kinase receptor</fullName>
            <ecNumber evidence="19">2.7.11.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">EGW08_012422</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">EC2010</strain>
            <tissue evidence="22">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-threonyl-[receptor-protein] + ATP = O-phospho-L-threonyl-[receptor-protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44880"/>
            <dbReference type="Rhea" id="RHEA-COMP:11024"/>
            <dbReference type="Rhea" id="RHEA-COMP:11025"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.30"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="19">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 19">Membrane</location>
            <topology evidence="1 19">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 19">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.30" evidence="19"/>
    <dbReference type="EMBL" id="RQTK01000426">
        <property type="protein sequence ID" value="RUS79823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BAX6"/>
    <dbReference type="STRING" id="188477.A0A3S1BAX6"/>
    <dbReference type="OrthoDB" id="69842at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004675">
        <property type="term" value="F:transmembrane receptor protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071363">
        <property type="term" value="P:cellular response to growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14143">
        <property type="entry name" value="STKc_TGFbR1_ACVR1b_ACVR1c"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TFP_LU_ECD_ALK4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Receptor protein serine/threonine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000023">
        <property type="entry name" value="Receptor protein serine/threonine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000472">
        <property type="entry name" value="Activin_recp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003605">
        <property type="entry name" value="GS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
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        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
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        <property type="entry name" value="TGFB_receptor"/>
    </dbReference>
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        <property type="entry name" value="Transform_growth_fac-b_typ-2"/>
    </dbReference>
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        <property type="entry name" value="RECEPTOR PROTEIN SERINE_THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="19" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 16 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 19" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 19" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="GS" evidence="21">
        <location>
            <begin position="215"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="252"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16 18">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR037393-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR037393-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR037393-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU361271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="RUS79823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="551" mass="62794" checksum="8030C1B69A94FFF7" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BBQ9</accession>
    <name>A0A3S1BBQ9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_012482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000429">
        <property type="protein sequence ID" value="RUS79766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BBQ9"/>
    <dbReference type="STRING" id="188477.A0A3S1BBQ9"/>
    <dbReference type="OrthoDB" id="6127189at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="468"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="522"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="642"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS79766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="749" mass="79712" checksum="7381D5FA1027CF76" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BG48</accession>
    <name>A0A3S1BG48_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_009347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000267">
        <property type="protein sequence ID" value="RUS82882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BG48"/>
    <dbReference type="OrthoDB" id="6048956at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS82882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="131" mass="15241" checksum="9B51C3200EA6B4B2" modified="2019-04-10" version="1">MTTNNPRQVMKPPRPLPGDLQTLPTLPWMFQWPMSAHERLILTNHTIYQQYPSSPCPATSHPYKDSWQFRDHSADDRVHPCHVDLRGGPKNVYNVAEKLPSQEPPQCDTRVSSNQPCCQESHVEPRNWFRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BH76</accession>
    <name>A0A3S1BH76_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_008355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000226">
        <property type="protein sequence ID" value="RUS83874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BH76"/>
    <dbReference type="STRING" id="188477.A0A3S1BH76"/>
    <dbReference type="OrthoDB" id="6287635at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS83874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="116" mass="13550" checksum="D9E712617ADE5981" modified="2019-04-10" version="1" fragment="single">MAYIGKYFHPSEVAMLVLGYLKERNLYKTFTCFIKESKDLEIYWQHIKSGQNPDLNICGYDLAAMLEEFAALRLARSDEGKPFVPAEKKSNVLSQLEAQRCLDEIEKERLKREQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BHE3</accession>
    <name>A0A3S1BHE3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_003864</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000085">
        <property type="protein sequence ID" value="RUS88352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BHE3"/>
    <dbReference type="STRING" id="188477.A0A3S1BHE3"/>
    <dbReference type="OrthoDB" id="6050630at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF4">
        <property type="entry name" value="CHORION PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS88352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="479" mass="54460" checksum="496D1CE94BD8A1F6" modified="2019-04-10" version="1" fragment="single">MDILSPGDQTPCHMRPKKERYREMDGRCNHPLDFGSAMKPVKRYIKPQYQDPEGYDTPRMFSVRGTNQPLPSPRAISRRLHTDRNLMDRHTMWLMQLGQFIDHDITSAPVPTEHNASIKCCGVPPDQVPKECFPISVPTDDPVFPPCMEFVRSEPWRDTEGKIKYPREQMNALTAFVDGSAIYGSDKEMMARLRVGGGKGALLKTVVVNGKERLPHDTQANSDMCLASHSTVSFCQLSGDGRVNEQPGLGSAHLLFHLFHNYIVKALTKGILGKHRRPNSELDVELYLHGEPDALQETIFQESRKIVGAVLQKITYCDWLPLILGPRLIRKYSLGCHGRSSYNHFVDPRIANAFLTAAFRFGHSLIPNQLSINQEKRDLKDQFMVPDNVLLHFETIMEGMQSAGSQQKFDRHVVDAVTDHLFESTKGPKGALDLIALNIQRGRDHGIPPYYAWRKYYGLSRLEKNGIEFRRTMRDALRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BHH1</accession>
    <name>A0A3S1BHH1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_008214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000220">
        <property type="protein sequence ID" value="RUS84036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BHH1"/>
    <dbReference type="OrthoDB" id="5974613at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS84036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="295" mass="32257" checksum="F8DA420D8B0662F3" modified="2019-04-10" version="1">MSTFENLHNYRRTNIDQTSLDNSPDSGVSVGSNELTSSRPVKYMANQGPMYIPHPNLQKAFKPIGALTSNSNSPSTMNLTQLSQNPQLSAPNRIQWKPQPWLQTPHSQMAQANHPRANNFSHPLSVNLTRPASPLPKVSPSLSQRFSSHDRAVSSPRTPRPVSQNQPGVRVFRNRNSTSTPSPSSTSSITSSISTSSITSSMSLAKNGSSATKVSPTTSSITQATEGTSPQQDSQTCSCDRSPKIILCKACGEMCQGRIRQKCKAHPNQIFLMDFTCCPYCQSENLKEIDYSKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BJS5</accession>
    <name>A0A3S1BJS5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_006784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000169">
        <property type="protein sequence ID" value="RUS85451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BJS5"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48209">
        <property type="entry name" value="AGL056WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48209:SF2">
        <property type="entry name" value="FI24008P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS85451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="303" mass="33417" checksum="83E34573BF930DB6" modified="2019-04-10" version="1">MMTKRKAGEEDDDGFNDKDDENDGNDDNGGGCYDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDEGDTGATLDVSIWLKVMSGLGLGLGHTTLLLTSAGLGERCILTICNMLTLRHDGKSVYTCPGCASSSTATTVTMASRTKVAAFLEDVARYTVRLDGLRAENAEQNRKLLMRMTHLFGFLNIIYDAYVGVSSYAKPVHIVEHHLYCAYACRRSAASNQSSILDLRSKWATRNFLPDERDYVIRYVMMMIAKRVLCPPGVHVTDAFPATIEQPPAPGDASTRLHSPVLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BK04</accession>
    <name>A0A3S1BK04_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_009662</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000280">
        <property type="protein sequence ID" value="RUS82588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BK04"/>
    <dbReference type="STRING" id="188477.A0A3S1BK04"/>
    <dbReference type="OrthoDB" id="270167at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01448">
        <property type="entry name" value="TST_Repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364:SF27">
        <property type="entry name" value="SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="THIOSULFATE SULFERTANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00380">
        <property type="entry name" value="RHODANESE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="99"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="263"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS82588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="400" mass="44386" checksum="BDD9123D12D4123D" modified="2019-04-10" version="1">MVCFDSTKTLRKRYCLEADMDFPEASDRPLRRCAGRLELRHFSSSADMSRTSVVSVASAKSSIFNLPLHNPPALVSPQWLMEALFTNQQEKDQSMKESQPHSVFLLDATWEATSTTSAYEQHYKRGHIPGALFLDLEALCQKQPNSHMCCPIPDPGKFERFVNNLGVSKDSHVVTYDSLDGRSAARVWYLFRLFGHEQVSVLDGGLRQWLQEGHQICTTDKDGTCRLPQEDQSLNTSQSTQKFKAKLQPNMLIGFTELKSIVEKEDAQIIDCRSELSSSEKPSTAYCSNATAMTSCASSHEVPSQGQIKGAIHIPFVNLFTPDGKFKLEEELLQVFEKAGVDLSVPAVVYSQRGMSACTVALAASICGIPTVPVYNGSWTEWEAMAPSCLIVKGKKTDQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BK78</accession>
    <name>A0A3S1BK78_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycoside hydrolase 35 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_023112</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001820">
        <property type="protein sequence ID" value="RUS69129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BK78"/>
    <dbReference type="STRING" id="188477.A0A3S1BK78"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000017">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019801">
        <property type="entry name" value="Glyco_hydro_35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01182">
        <property type="entry name" value="GLYCOSYL_HYDROL_F35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018685574" description="Glycoside hydrolase 35 catalytic domain-containing protein" evidence="6">
        <location>
            <begin position="24"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase 35 catalytic" evidence="7">
        <location>
            <begin position="39"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS69129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="307" mass="34644" checksum="FE9E52AADD60B73D" modified="2019-04-10" version="1">MATRTIFTFSATLFLLTFLLSESESLKQPTFEIDYENDTFMKDGKPFRYVSGSFHYSRVHPFYWKDRLVKTRAAGVNTIQVYVPWNVHELTSGKFSWDGASDLPRFLTLAQEADLAVLLRLGPYICGEWEFGGFPAWLLTANASMVLRTSDPSYMKYVDRWFTALLAKVKPFLYNNGGPILMVQTENEYGSYFACDFVYLKYLRDKVLAALGEETVLYSTDGDGAGYLKCGKVDGVYATVDFGITTNPAGAFNVQREFEPKGPLVNSEFYTGWLDHWGSKHSTVGMVPLANSLDLLLNYSNSTNINM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BM15</accession>
    <name>A0A3S1BM15_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_005517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000130">
        <property type="protein sequence ID" value="RUS86727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BM15"/>
    <dbReference type="OrthoDB" id="8963449at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS86727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="135" mass="15353" checksum="B84AE734B2320E8F" modified="2019-04-10" version="1">METDDDDWGEDEEPDYEDIDLYLTPPYSTLLHFTPPYSTIPHLTLPYSTSLHLTPPYSTILHLTPPHSTSLHHTPPHSTLLHHTSPYFSILHLTSPYSTSLHLTPPYFTILHLTPPYFTILYLTPPFPLHPGAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BNS4</accession>
    <name>A0A3S1BNS4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">V-type proton ATPase subunit S1/VOA1 transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_004253</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the vacuolar ATPase subunit S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000095">
        <property type="protein sequence ID" value="RUS87975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BNS4"/>
    <dbReference type="STRING" id="188477.A0A3S1BNS4"/>
    <dbReference type="OrthoDB" id="9985059at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033176">
        <property type="term" value="C:proton-transporting V-type ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030641">
        <property type="term" value="P:regulation of cellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008388">
        <property type="entry name" value="Ac45_acc_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046756">
        <property type="entry name" value="VAS1/VOA1_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12471:SF7">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12471">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20520">
        <property type="entry name" value="Ac45-VOA1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018557432" description="V-type proton ATPase subunit S1/VOA1 transmembrane domain-containing protein" evidence="7">
        <location>
            <begin position="28"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="V-type proton ATPase subunit S1/VOA1 transmembrane" evidence="8">
        <location>
            <begin position="404"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS87975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="455" mass="50080" checksum="D9E8C2650D27E3C6" modified="2019-04-10" version="1">MDVQSRMPSRITFLLYSILILLHKGSAQLGTPALFWSPEKSMSHLPEVNGVDPVNSDLLEKEYLKPLMQHAGESAVVFLKDKLHVDDFTKFADVYSLDSNGGAFKNIKHFMDENFSLEIPQVEDPLKAVEGLKLSFAGAVHSADSLAAVEKLNLGPDQKFLLIVELQPSSDLSEEQAIASNDASVGEICHHLQKRGISYTAMFTGKSASENQAEEVETFSGRHLLAEADSNNGTFMNADGAYLFLRDVQVHIAQKGKDPINLNLTVESSSADKSLVDNSTALIQFDFNDGSENGTGSYQVKIVFNTTRNGDRWTINQIRLTVDGIAEAGPNGTLSDSPLRTDDLDLVVPILYSYHCSSMKMYVDYIRNKGLVNYAGSYVVLNGLQMQPFNVQKGAFFNAQDCVGFFTRGIWMGIFSSLILLAILFFGVMMVLNLSTPDRFDDPKGKTITIAQAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BPW1</accession>
    <name>A0A3S1BPW1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_003594</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="RQTK01000077">
        <property type="protein sequence ID" value="RUS88635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BPW1"/>
    <dbReference type="STRING" id="188477.A0A3S1BPW1"/>
    <dbReference type="OrthoDB" id="9632060at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="28"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS88635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="226" mass="25880" checksum="46E2ACAE62128CBB" modified="2019-04-10" version="1">MALFQPTKFENPYTIHKFEDDFYQKYNLKKVQFLGEGMAGKVYLVKPKSGRGRWQAVKEFSHYPTEVRERNMKHFVMETTVMQLVSHPHLVPCHLAASGHDYSAIVMPYYPQGDLVLSGRQEPNRVHRLMSQVARAVEHLHKWNIAHNDIKLENVFVDGSDDAHLGDMGFALRLKDPLELSPAWRVGGTKVYWSPEKLAANPHDKIDAFKAFDVISLTALNSLTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BUY2</accession>
    <name>A0A3S1BUY2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_000045</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="3"/>
    <dbReference type="EMBL" id="RQTK01000001">
        <property type="protein sequence ID" value="RUS92192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BUY2"/>
    <dbReference type="STRING" id="188477.A0A3S1BUY2"/>
    <dbReference type="OrthoDB" id="273917at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043634">
        <property type="term" value="P:polyadenylation-dependent ncRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000006">
        <property type="entry name" value="non-canonical poly(A) RNA polymerase PAPD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000003">
        <property type="entry name" value="non-canonical poly(A) RNA polymerase PAPD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045862">
        <property type="entry name" value="Trf4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092:SF15">
        <property type="entry name" value="INACTIVE NON-CANONICAL POLY(A) RNA POLYMERASE PROTEIN TRF4-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092">
        <property type="entry name" value="POLY(A) RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="9">
        <location>
            <begin position="112"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="8">
        <location>
            <begin position="304"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="470"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="506"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="618"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="719"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="479"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="507"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="536"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="571"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="589"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="643"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="673"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="733"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="769"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="791"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS92192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="801" mass="88560" checksum="A0710FB6307AB0AF" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BVU4</accession>
    <name>A0A3S1BVU4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_002250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WSCD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000043">
        <property type="protein sequence ID" value="RUS89983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S1BVU4"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051589">
        <property type="entry name" value="Sialate-O-sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964:SF5">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="57"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="285"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="341"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="545"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="728"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="953"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1070"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1202"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="396"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="668"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="82"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="142"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="347"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
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            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="601"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="728"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="741"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="762"/>
            <end position="809"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="823"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="953"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1071"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1089"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1115"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1145"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1202"/>
            <end position="1219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS89983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1450" mass="158305" checksum="031DE92EAF852174" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BWN1</accession>
    <name>A0A3S1BWN1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_015423</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000634">
        <property type="protein sequence ID" value="RUS76805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BWN1"/>
    <dbReference type="STRING" id="188477.A0A3S1BWN1"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00878">
        <property type="entry name" value="Arf_Arl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000412">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="130"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS76805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="193" mass="21493" checksum="5D673B43D3944006" modified="2019-04-10" version="1">MGLFMSRLFELFQGFSAGENRRILMLGLDAAGKTTILYKVKLNENVCTIPTIGFNVETVTPVKGVNFTVWDVGGQEKIRQLWRHYYANAQGLLFIVDSADRIRLEEARQELFGIIKAPDMERVPVVVVANKQDLPGALSTAEVADGLGLREMRDRKWYVQGACAVDAGDGPVSQRGLQKLKSLLVKFKEVYNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BZL2</accession>
    <name>A0A3S1BZL2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SOCS box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_013238</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000478">
        <property type="protein sequence ID" value="RUS78981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BZL2"/>
    <dbReference type="STRING" id="188477.A0A3S1BZL2"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="84"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="4">
        <location>
            <begin position="232"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS78981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="282" mass="30903" checksum="A230634D01CFC38C" modified="2019-04-10" version="1">MGNSRSSKNCAVSMAMGMPQRERELHVAVINNNTPDVISVLKQGVDINYPWSNPAVPSIKDSTTPLIAAILIRNGASINRTDKYGCTPLYKAAFHGRVTLVDMLLKEGAEVDKADKENQTPLYICVQNAIVHSSYATVMRLLAAGASVNIHVNAVDNKGRTPLYVCVASLSTGLYKEDLKYQVPCIKILFAAGCDMLNLEDWIRCKGPGIPPELLTGDESFLTWYNSAMTCPPTLRNMCRKAVQKCLVTYDCPGLVKGVARLPVPPSLKIFLSRKMFHLSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C9L7</accession>
    <name>A0A3S1C9L7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_005551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000131">
        <property type="protein sequence ID" value="RUS86677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C9L7"/>
    <dbReference type="OrthoDB" id="10622861at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS86677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="340" mass="33064" checksum="3950F976651BAD20" modified="2019-04-10" version="1">MGGAMGGAMGGAMGTMSGTMGGAMGTMGGTMGGAMGGAMGAMSGAMGGAKVGAMGGAMGGAMGGAMGGAMGGYMGGAMGTLSGAMGGAKGGAMGKMSGAMGGAKGGAKGGAMGGAMGGAMGAIECAEQLNPSPLMNALMPNRNQVAAMAAPSNFMSPYQMIMQNNNANPMGAYGNPLQPTLTPISPYLGGAMNPMMTMNPGMTRPGQTFQTGANSFSSLLPSATPLMAQPGAMPMPSALGQTSNILAHQNVNLATKDARSSMAGNSNMAAGSMTQPNFSNMATGLMAPQIKVPTMASTLMNFGQGSMQPSGMTLNSPLMTSGGYTPGGKLLLRLWPFSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1CCG2</accession>
    <name>A0A3S1CCG2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_003349</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000071">
        <property type="protein sequence ID" value="RUS88910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S1CCG2"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22706">
        <property type="entry name" value="FHA_KIF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01365">
        <property type="entry name" value="KISc_KIF1A_KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000002">
        <property type="entry name" value="Kinesin family member 13A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000167">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022164">
        <property type="entry name" value="Kinesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022140">
        <property type="entry name" value="Kinesin-like_KIF1-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032405">
        <property type="entry name" value="Kinesin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12473">
        <property type="entry name" value="DUF3694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12423">
        <property type="entry name" value="KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16183">
        <property type="entry name" value="Kinesin_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="11">
        <location>
            <begin position="1"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="527"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS88910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1298" mass="144896" checksum="9298F49B5E26E863" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HQW4</accession>
    <name>A0A3S1HQW4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_007837</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000207">
        <property type="protein sequence ID" value="RUS84375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HQW4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS84375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="116" mass="13435" checksum="34B06A4215BB5F5B" modified="2019-04-10" version="1" fragment="single">MNFNILMAEQRHQERDHTTVNDHLDLAVPTVSQVRQSPHSVNQNLKEETQIKLTQSREDFLYRVFGWRGVFVAAQIHNYPRHVAQERQRDAGIDEGQQVLHCAQLDHIVSALRAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HUN3</accession>
    <name>A0A3S1HUN3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_005813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000139">
        <property type="protein sequence ID" value="RUS86435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HUN3"/>
    <dbReference type="STRING" id="188477.A0A3S1HUN3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS86435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="144" mass="16119" checksum="17C11303C268CD66" modified="2019-04-10" version="1" fragment="single">STTPSPGSKLISTFVLNATTVQRLHALSTKPKSLQLNRASERASQRASERASQRASQRAYQRASQRASQRASQRASQRASQRISQRASQRTSQRASQRASQRAYQRASQRASQRAYQRASQRASQRTSQRASQRTSQRASQRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SJD8</accession>
    <name>A0A433SJD8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kringle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_023147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001837">
        <property type="protein sequence ID" value="RUS69092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SJD8"/>
    <dbReference type="OrthoDB" id="10393127at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.20.10">
        <property type="entry name" value="Plasminogen Kringle 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038178">
        <property type="entry name" value="Kringle_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS69092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="134" mass="15046" checksum="3F19E2240577CAF3" modified="2019-05-08" version="1" fragment="single">MVHSSCVASAGSIYTTLSVGQILALRLSGVSQVVGRITYKADPVCPPTFTPRGQVTCHDTEGIWQNQNSLACFPLECYQQRGIHQYYAGYKSVTKSGRPCWYWRDQGPMSNNMIDQPFPFDNNDKVQAKNYCRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SKK1</accession>
    <name>A0A433SKK1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">hydroxyacylglutathione hydrolase</fullName>
            <ecNumber evidence="4">3.1.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glyoxalase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_022571</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.6" evidence="4"/>
    <dbReference type="EMBL" id="RQTK01001610">
        <property type="protein sequence ID" value="RUS69666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SKK1"/>
    <dbReference type="STRING" id="188477.A0A433SKK1"/>
    <dbReference type="OrthoDB" id="17458at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004416">
        <property type="term" value="F:hydroxyacylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07723">
        <property type="entry name" value="hydroxyacylglutathione_hydrolase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035680">
        <property type="entry name" value="Clx_II_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050110">
        <property type="entry name" value="Glyoxalase_II_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032282">
        <property type="entry name" value="HAGH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43705">
        <property type="entry name" value="HYDROXYACYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43705:SF1">
        <property type="entry name" value="HYDROXYACYLGLUTATHIONE HYDROLASE GLOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16123">
        <property type="entry name" value="HAGH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS69666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="208" mass="23804" checksum="9229D477E4C1259F" modified="2019-05-08" version="1" fragment="single">NYQYLIYDDIHAILVDPLREGFFTDFIEQNNLTITAILITHKHGDHIAGVNDIVAKNNDVKVYAYADNERFSPDVYVKDGDVLEFGYTTIKVLYTPGHIADHVSYLFVDEKDLFCGDTVFNAGVGGVSAKTANVNELYDSIVSINDLDEQTKLYPAHDYWQGNLDFALSILPNDEKFMYYRKNVAELEADDKPILTIKEERELNIFFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SKZ9</accession>
    <name>A0A433SKZ9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_022437</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001571">
        <property type="protein sequence ID" value="RUS69804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SKZ9"/>
    <dbReference type="STRING" id="188477.A0A433SKZ9"/>
    <dbReference type="OrthoDB" id="6158938at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS69804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="370" mass="40676" checksum="7508EDB329863C01" modified="2019-05-08" version="1" fragment="single">MRDPARVSCPECEFTSSKESRLARHMRKSHGKTGVRVSCPECEFTSSKESRLARHMRKSHGKTGVRCPLCVGVHYSSSPEQLCVHKKQQHRSVRLRCFLCDFSSRSLRSWAGHLTRIHSGVTSSLVSLASGVGRSTSQTVPPAPESVGVVEPTSDSYVQVDEDILVRESKLSDSDSVAEPTSDSYVQVDEDILVRESKLSDSDSVAEPTSDSYVQVDEDILVRESKLSDSDSVAEPTSDSYVQVDEDILVRESKLSDSDSVAEPTSDSYVQVDEDILVRESKLSDSDSVAEPTSDSYVQVDEDILVRESKLSDSDSAAEPTSDSYVQVDEDILVRESKLSDSDSVAEPTSDSYVQVDEDILVRESKLSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SL84</accession>
    <name>A0A433SL84_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_022351</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001546">
        <property type="protein sequence ID" value="RUS69889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A433SL84"/>
    <dbReference type="OrthoDB" id="616263at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046974">
        <property type="term" value="F:histone H3K9 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002039">
        <property type="term" value="F:p53 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20905">
        <property type="entry name" value="EHMT_ZBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043550">
        <property type="entry name" value="EHMT1/EHMT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047762">
        <property type="entry name" value="EHMT_CRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46307">
        <property type="entry name" value="G9A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46307:SF4">
        <property type="entry name" value="G9A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21533">
        <property type="entry name" value="EHMT1-2_CRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05033">
        <property type="entry name" value="Pre-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00468">
        <property type="entry name" value="PreSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1351"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1384"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1417"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1451"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1484"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1517"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-SET" evidence="5">
        <location>
            <begin position="1591"/>
            <end position="1690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="46"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="433"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="506"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1033"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="440"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="514"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="565"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="667"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="686"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1033"/>
            <end position="1056"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS69889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1732" mass="184188" checksum="68970C2DA733918F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SLC9</accession>
    <name>A0A433SLC9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_022280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001528">
        <property type="protein sequence ID" value="RUS69953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SLC9"/>
    <dbReference type="STRING" id="188477.A0A433SLC9"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="2">
        <location>
            <begin position="248"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS69953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="299" mass="31383" checksum="7CA4EFA7D32EF508" modified="2019-05-08" version="1" fragment="single">NEDGDRNFNNDAVSQDNTKTSSTVTSNADRDQNNISEGSAVTDGREMAGIQSDTEGQGHATLDTSRPSTTTSTSIIHAKEETGTTHTSPQSPPGQDQRPESAAAGDLPHPEPSLSNKPPGETHRPDPMLNEITEETPEGTGQTSLESPLDMSSSEPPCTAETETINTNSPAVLSLPTTTTTTTTTTTTTSDTAEDKLHVLQTHTKDRSKLGSGSSLKDENTAARLQISSEGEDLAGGGGGGGGGEVVVVTGGCGFLGQHVVKMLQERAPHVAEIRVLDIKEFRQRLDYPAKKPVRSIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SPB1</accession>
    <name>A0A433SPB1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RAD50-interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_021151</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RINT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001275">
        <property type="protein sequence ID" value="RUS71090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SPB1"/>
    <dbReference type="STRING" id="188477.A0A433SPB1"/>
    <dbReference type="OrthoDB" id="2189254at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070939">
        <property type="term" value="C:Dsl1/NZR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060628">
        <property type="term" value="P:regulation of ER to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.670:FF:000003">
        <property type="entry name" value="RAD50-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1420">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.670">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042044">
        <property type="entry name" value="EXOC6PINT-1/Sec15/Tip20_C_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007528">
        <property type="entry name" value="RINT1_Tip20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042042">
        <property type="entry name" value="Tip20p_domB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13520:SF0">
        <property type="entry name" value="RAD50-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13520">
        <property type="entry name" value="RAD50-INTERACTING PROTEIN 1 RINT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04437">
        <property type="entry name" value="RINT1_TIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51386">
        <property type="entry name" value="RINT1_TIP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00061158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS71090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="780" mass="89544" checksum="FD7815660D17F0D7" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SRA0</accession>
    <name>A0A433SRA0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_020447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001158">
        <property type="protein sequence ID" value="RUS71794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SRA0"/>
    <dbReference type="OrthoDB" id="10685725at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="321"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="459"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS71794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="547" mass="60756" checksum="D0120CDCF9BB607B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SSU7</accession>
    <name>A0A433SSU7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_019904</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001079">
        <property type="protein sequence ID" value="RUS72333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SSU7"/>
    <dbReference type="STRING" id="188477.A0A433SSU7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS72333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="323" mass="36002" checksum="9F62C1DD11571227" modified="2019-05-08" version="1">MEKTWTWNNGPYPTDRLVPFRTRPLSRQAEMGESKMDVQSAEPQLRLRRTAGLQYPLCLVLIKPSESGGRAIKLPNYHSLVVSVSSHVPLCACPVSLGCSAWCMRAARNLPLCAGIAISHYFENASSVLIDLLDRGHITKYQDNRYVDRTTGKRKAIRDGVGKGGMSFSYGCPNWTVRPMSTMSSCESRRSVMERAVGLEIECPRDVPSAFSCSEGPRWPWVGTLASDAKGILEKSVFKVLNREPENNGGRPTQIKFCLPIAKHRNRRATRKLSLLRQDSGSSIVRLLLSEWREGVEGLLRVIGSDNHKEFRSGLIEGRVESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SXR4</accession>
    <name>A0A433SXR4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_018141</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000866">
        <property type="protein sequence ID" value="RUS74094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SXR4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS74094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="234" mass="27908" checksum="14A09E2BD91E19DC" modified="2019-05-08" version="1">MFLDKKIKFLPNINHAGSQHHHDDNGGDDVDDDDDDDDDDDDDNDDDDDDDDDDDDDDDDDDDDNDDDDDDDDDDDDDDDDDDDDNDDDDDDDDDDDDDDDDDDDDNDDDDDDDDDDDDDDDDDDDDNDDDDDDDDDDDDDDDDDDDDNDDDDDDDDDDDDDDDDDDDDNDDDDDDDDDDDDDDDDDDDDNDDDDYYYYYYYYYYYYYYYYYYYYYFFFLITIITIIIIITSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SZR9</accession>
    <name>A0A433SZR9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_017442</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000798">
        <property type="protein sequence ID" value="RUS74796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6153344at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="729"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="856"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="961"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1169"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1266"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="658"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="729"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="747"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="961"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1006"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1046"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1169"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1215"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1266"/>
            <end position="1284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS74796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1292" mass="142083" checksum="DBC3166DA5483F1F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T0U8</accession>
    <name>A0A433T0U8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amine oxidase</fullName>
            <ecNumber evidence="7">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_017055</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a secondary aliphatic amine + O2 + H2O = a primary amine + an aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:26414"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:58855"/>
            <dbReference type="ChEBI" id="CHEBI:65296"/>
            <dbReference type="EC" id="1.4.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="7"/>
    <dbReference type="EMBL" id="RQTK01000765">
        <property type="protein sequence ID" value="RUS75174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T0U8"/>
    <dbReference type="STRING" id="188477.A0A433T0U8"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097621">
        <property type="term" value="F:monoamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050703">
        <property type="entry name" value="Flavin_MAO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563:SF14">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="512"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="8">
        <location>
            <begin position="15"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601613-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS75174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="545" mass="59291" checksum="1C3852CBECC944AD" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T3Y1</accession>
    <name>A0A433T3Y1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_016027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000680">
        <property type="protein sequence ID" value="RUS76220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T3Y1"/>
    <dbReference type="STRING" id="188477.A0A433T3Y1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS76220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="120" mass="14424" checksum="21B994D273C03A8D" modified="2019-05-08" version="1" fragment="single">PWKAGLNLYLPWEACLNLYLPWQACLHLYLPWEACSKLYLPWEACLNLYLSWEACLNLYLSWEACLNLYLPWEACLNLYLPWEACLNLYLPWQACLHLYLPWEACLNLYLPWEACLNLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T535</accession>
    <name>A0A433T535_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_015592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000647">
        <property type="protein sequence ID" value="RUS76644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T535"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS76644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="21924" checksum="42FEBECED059A770" modified="2019-05-08" version="1" fragment="single">LYLPLSLYFLHYIFLCVHFLLCISLSIHLSIYLTIYLSIYLSIYLSIYLSIYLSIYLSIYLSICLSIYLTMQYIYCLYFYLYPDLHIHSHVYIRSIYLTMQYIYCLYFYLYPDLHIHSHVYIRVSLCIYLSIYLSIYLSIYLSIYLSIYLSIYLSIYLSIYLSIYLSSYLAIYPYLSFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T6B4</accession>
    <name>A0A433T6B4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-lysine N-methyltransferase EGW08_015149</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_015149</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="RQTK01000611">
        <property type="protein sequence ID" value="RUS77094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T6B4"/>
    <dbReference type="STRING" id="188477.A0A433T6B4"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03188">
        <property type="entry name" value="Methyltr_EFM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026635">
        <property type="entry name" value="Efm4/METTL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843:SF5">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE METTL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="6">
        <location>
            <begin position="116"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS77094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="283" mass="31398" checksum="74AD061625583471" modified="2019-05-08" version="1">MAMDPVTSDVKLVGQLISTSGASELKVHQSHFLSLLLSFSTRQKVVLSPDSLKMSDDCGDFGSSELGTKEYWDAAYGRELKNFKDIGDVGEIWFGEDVQMRMVRWVSERSNLPTSARLLDLGCGNGTLLIGLREEEFSDLTGVDYSEGAIQLAKDVAEKEGVDDINFQVCDILCPKSVSTLTKDGSNRFDLCLDKGTYDAISLRDPTEPTDRRKYAVHVHSLLNEQGLLVITSCNWTKDQLVLHFEKEFELLQELPAPSITFGGQTGQTVTTLILKRKALDHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T7P7</accession>
    <name>A0A433T7P7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Histone deacetylase 8</fullName>
            <ecNumber evidence="6">3.5.1.98</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Protein deacetylase HDAC8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Protein decrotonylase HDAC8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">EGW08_014621</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">EC2010</strain>
            <tissue evidence="24">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>N(6)-(2E)-butenoyl-L-lysyl-[protein] + H2O = (2E)-2-butenoate + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:69172"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13707"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:35899"/>
            <dbReference type="ChEBI" id="CHEBI:137954"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:69173"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:58197"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>N(6)-acetyl-L-lysyl-[protein] + H2O = L-lysyl-[protein] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58108"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:58109"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the histone deacetylase family. HD type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="6"/>
    <dbReference type="EMBL" id="RQTK01000566">
        <property type="protein sequence ID" value="RUS77621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T7P7"/>
    <dbReference type="STRING" id="188477.A0A433T7P7"/>
    <dbReference type="OrthoDB" id="73273at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000006">
        <property type="entry name" value="Histone deacetylase 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF14">
        <property type="entry name" value="HISTONE DEACETYLASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0678">Repressor</keyword>
    <keyword evidence="14" id="KW-0804">Transcription</keyword>
    <keyword evidence="13" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="23">
        <location>
            <begin position="379"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00040347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="RUS77621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="728" mass="80811" checksum="B86F51C7A2864537" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T809</accession>
    <name>A0A433T809_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_014570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000561">
        <property type="protein sequence ID" value="RUS77673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T809"/>
    <dbReference type="OrthoDB" id="6067390at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS77673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="78" mass="9411" checksum="A71C3AB087C9C6D4" modified="2019-05-08" version="1">MPVEKIRGGGELFKHHWTTFSKVQQAPIKFYWKYGRMFRYYVYSAAIVFPLFMFLTKASYAPANVKQWEQIRAGRRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T834</accession>
    <name>A0A433T834_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_014498</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000556">
        <property type="protein sequence ID" value="RUS77739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T834"/>
    <dbReference type="STRING" id="188477.A0A433T834"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005366">
        <property type="term" value="F:myo-inositol:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF12">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019568919" description="Major facilitator superfamily (MFS) profile domain-containing protein" evidence="7">
        <location>
            <begin position="25"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS77739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="154" mass="16779" checksum="6258DB30B1DF6429" modified="2019-05-08" version="1">MSSSWVAFFGLMFFVLAFAPGAGPMPWTVNAELYPLWARSVANSLSTWTNWCCNYIVSNLFLTAAKVFSISGILFGFSVVCLMAALFSAYAVPETRNISLEQLGKGSFSAVSSVKTTATLNDAVDILQLRKKVKHPEKSEEIVSATQSNVYTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T9U4</accession>
    <name>A0A433T9U4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Egal-1 winged helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_013935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000519">
        <property type="protein sequence ID" value="RUS78300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T9U4"/>
    <dbReference type="STRING" id="188477.A0A433T9U4"/>
    <dbReference type="OrthoDB" id="26838at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056589">
        <property type="entry name" value="WH_Egal-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23713">
        <property type="entry name" value="WHD_Egal"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Egal-1 winged helix" evidence="2">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Egal-1 winged helix" evidence="2">
        <location>
            <begin position="105"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Egal-1 winged helix" evidence="2">
        <location>
            <begin position="244"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS78300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="518" mass="56741" checksum="5D3BBBAC1774E0F2" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T9Z1</accession>
    <name>A0A433T9Z1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_013821</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000511">
        <property type="protein sequence ID" value="RUS78407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T9Z1"/>
    <dbReference type="OrthoDB" id="10025474at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS78407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="708" mass="80677" checksum="A54FE188259638FA" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TAF3</accession>
    <name>A0A433TAF3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_013672</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000502">
        <property type="protein sequence ID" value="RUS78565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TAF3"/>
    <dbReference type="STRING" id="188477.A0A433TAF3"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000557">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="30"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="244"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="473"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="59"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="259"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="473"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="501"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS78565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="512" mass="55928" checksum="369EA0D0E272C1B7" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TCQ8</accession>
    <name>A0A433TCQ8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_012879</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000456">
        <property type="protein sequence ID" value="RUS79358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TCQ8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS79358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="265" mass="29480" checksum="AE91CA8D44326F89" modified="2019-05-08" version="1">MTISSERMPWFPSLQECQVSRTLPISTGLLTWRAASNPRVTHSVTCTAAPGSLYKIRDRATRAAPCWALVISGIYRIIPGIYRIMGDGASRVDRGNFAGEPLDTAKSIECYRSILSASSCKCHSPTCEGNKLFTAGCPRTTTRYKWRKAREIRPDNSANCGIFLNTQIVINEANRQSRLFKLPVDSECFRLSKRLRCVSLTHAGLVLGSARAHEGNQLTRMRHDSYFGAGSLELLRLLPLSLPVRMIAHPGTGTQGNSWCHVKRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TDA7</accession>
    <name>A0A433TDA7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">POU domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_012801</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the POU transcription factor family. Class-6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000451">
        <property type="protein sequence ID" value="RUS79424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TDA7"/>
    <dbReference type="STRING" id="188477.A0A433TDA7"/>
    <dbReference type="OrthoDB" id="10066259at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000051">
        <property type="entry name" value="POU domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000013">
        <property type="entry name" value="POU domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013847">
        <property type="entry name" value="POU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000327">
        <property type="entry name" value="POU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050255">
        <property type="entry name" value="POU_domain_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636">
        <property type="entry name" value="POU DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636:SF5">
        <property type="entry name" value="POU DOMAIN MOTIF 3, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00157">
        <property type="entry name" value="Pou"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00028">
        <property type="entry name" value="POUDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00352">
        <property type="entry name" value="POU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00035">
        <property type="entry name" value="POU_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00465">
        <property type="entry name" value="POU_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51179">
        <property type="entry name" value="POU_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="POU-specific" evidence="12">
        <location>
            <begin position="241"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="11">
        <location>
            <begin position="334"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="8">
        <location>
            <begin position="336"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS79424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="403" mass="43215" checksum="E5FD96E2993F812C" modified="2019-05-08" version="1">MSSLTSQTQLLGQPQVAPQFFLASQPSASASTGQTGSGGHVPVQQILIPVSTTNGAQQFISIPVSLATGGNQQIQLITTNNGGQFLATNLSNLQALTQPLAKLASSRDSHSISSSSSHSSHGLSGLATLPQLLSTSTGQILAVSPQLLSSLPLSSSHLSSSGSSSSSSSLAAVNQAAAATAQQVLQHTLSQAMAASVNQHHVASSKLIQQAHIHSSTNGLPPNVSQLLPHTVGNSTESTTVDGINLDEIKEFARQFKIRRLSLGLTQTQVGQALSATEGPAYSQSAICRFEKLDITPKSAQKIKPVLERWMAEAEERYKNGVQNLTDFIGSEPSKKRKRRTSFTPQALELLNQYFERNTHPTGTEMTELSERLNYDREVIRVWFCNKRQALKNTIKKLKQDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TE51</accession>
    <name>A0A433TE51_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_012480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000429">
        <property type="protein sequence ID" value="RUS79764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TE51"/>
    <dbReference type="STRING" id="188477.A0A433TE51"/>
    <dbReference type="OrthoDB" id="6127189at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050179">
        <property type="entry name" value="Trans_hexapeptide_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43300:SF10">
        <property type="entry name" value="2,3,4,5-TETRAHYDROPYRIDINE-2,6-DICARBOXYLATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43300">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="569"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS79764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="594" mass="62910" checksum="BB659EB3EA95A35F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TGD0</accession>
    <name>A0A433TGD0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_011649</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Toll-like receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000383">
        <property type="protein sequence ID" value="RUS80594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TGD0"/>
    <dbReference type="STRING" id="188477.A0A433TGD0"/>
    <dbReference type="OrthoDB" id="1421090at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365:SF541">
        <property type="entry name" value="PROTEIN TOLL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365">
        <property type="entry name" value="TOLL-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01582">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01537">
        <property type="entry name" value="INTRLKN1R1F"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="11">
        <location>
            <begin position="239"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="390"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="390"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS80594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="442" mass="51568" checksum="B138B3E2EA3820B5" modified="2019-05-08" version="1" fragment="single">DTRTSCQYSNLRIMDESMAQFTPLFHFEFLVQGANYPVLEVMNYSRIGMKELPRELSEWRRHFPRLKYLDLTHNHISSVSVKKFPTLAPTGRVTFDLRYNNITNINRDILTKWRKVEDFFVDIRNNPINCDCDMKDFLLSLKNPLEPYLQQYEYIREMRCVTPDNLAGTLLKSVNEESLQCMGVVSSNRTALIILGGTVFVLLLLMLVVIRYKVEIRILLYTRLHVRLPCDADASCNLKKYDAFVSYSNDDAVWVYEHLVKFLEGSETAPEKQFRLCLHQKDFVPGKTIVDNIVDCIEASRHTIIVLSPRFMKSHWAMEELRQAYRQSLVEKTRHLIVILLETVPKEDMDPLIARCCRTFTYLNANDSLFRDRLIFSLTTKDRYTRRRDRLAAKEQKRQEKLELESGQDNPAFTVQIPRPPDPVRGLSNISTTSTSVLADYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433THU7</accession>
    <name>A0A433THU7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_011172</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000356">
        <property type="protein sequence ID" value="RUS81086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433THU7"/>
    <dbReference type="STRING" id="188477.A0A433THU7"/>
    <dbReference type="OrthoDB" id="6135864at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17317">
        <property type="entry name" value="MFS_SLC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="481"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="552"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="154"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS81086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="607" mass="67685" checksum="D30B990EE9BAF11F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TLR8</accession>
    <name>A0A433TLR8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_009758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000284">
        <property type="protein sequence ID" value="RUS82495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TLR8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36489:SF2">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36489">
        <property type="entry name" value="PROTEIN-COUPLED RECEPTOR GPR1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS82495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="171" mass="18919" checksum="49E1579348806015" modified="2019-05-08" version="1" fragment="single">PSGQPNNQPTNQPTNQPTNQPTNQPTNQPTNQPTTNQPTNQPTNQPTNQPTNQTNQPTNQPTNQPIRPRDGQPTNQSTIWATKQPTNQLTNQPTNQPTNQPTNQPTNQPTNQPTNKPTNQPTNQPTKKPTNQPTNQPTNQPTNQPTNQPTNQPTNQPNKPTNQPTNQPINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TPI8</accession>
    <name>A0A433TPI8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_008749</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000241">
        <property type="protein sequence ID" value="RUS83499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TPI8"/>
    <dbReference type="STRING" id="188477.A0A433TPI8"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000113">
        <property type="entry name" value="homeobox protein Hox-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046327">
        <property type="entry name" value="HXA1/B1/D1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45946">
        <property type="entry name" value="HOMEOBOX PROTEIN ROUGH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45946:SF4">
        <property type="entry name" value="HOMEOBOX PROTEIN ROUGH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="84"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="86"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="20"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS83499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="184" mass="19539" checksum="59AA719FC588C035" modified="2019-05-08" version="1">MSDPPVWLAARTSIMEMDESWTLGGRKGPAGKSQDYNTSSNGYSSTSSGNHGTAHASSNGTSGAVGGTGNGGLSSVVSGGGAAGNAGSGRTNFTNKQLTELEKEFHFNKYLTRARRIEIAAALGLNETQVKIWFQNRRMKQKKRMREIQFEKVNSGVDPSSCQGQLGGLEGLTVPNLALCHDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TRT2</accession>
    <name>A0A433TRT2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_008048</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0489 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000214">
        <property type="protein sequence ID" value="RUS84208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TRT2"/>
    <dbReference type="STRING" id="188477.A0A433TRT2"/>
    <dbReference type="OrthoDB" id="418142at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024131">
        <property type="entry name" value="UPF0489"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13225">
        <property type="entry name" value="MISEXPRESSION SUPPRESSOR OF RAS 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13225:SF3">
        <property type="entry name" value="UPF0489 PROTEIN C5ORF22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS84208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="291" mass="32123" checksum="22BA390DCA9C01FE" modified="2019-05-08" version="1" fragment="single">QGLGEEKIQELEVLCQTLLQHNLRNGQDSSSSKTSFSSIHHSVLSDPAVHTQSSNPLASCTPKTSTCTSPSKPDDLSQTDSINSDISIRVTDNASNVGEKESQSHMKPCESLLSENSEKISPQCEPKQLSACEKPLENVLSMQKEPCDKQTKTTLKCEQTLEILHSTMPESFDRQGKETLTLDNEPSKDGFLGGQISQRESLTFLQLHDFGCTLDDTELPHHLSSQPQVAALMSEIKVMLESLPRPALVTIARSSDDGYCPKGEVDLYQRDILKMLEEIFGSLTVTEHYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TRW1</accession>
    <name>A0A433TRW1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_007973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000211">
        <property type="protein sequence ID" value="RUS84280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TRW1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS84280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="102" mass="11343" checksum="6E3EAD2287A0FC38" modified="2019-05-08" version="1" fragment="single">VMLIFDNEDHVKPRQNGWHEVNVLSSLSIIPAPKHRVGSSQHRAARVQCSCDASLTNLGNRYGLLLHGLVNSNPIILSHFVKLINADNPTISQDHSTTFHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TSQ8</accession>
    <name>A0A433TSQ8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_007666</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000201">
        <property type="protein sequence ID" value="RUS84571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TSQ8"/>
    <dbReference type="STRING" id="188477.A0A433TSQ8"/>
    <dbReference type="OrthoDB" id="10047851at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034605">
        <property type="entry name" value="PGC-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15528:SF11">
        <property type="entry name" value="FI18188P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15528">
        <property type="entry name" value="PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1 PGC-1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="755"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="488"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="528"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="493"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="543"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="570"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="620"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="673"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="714"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="731"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS84571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="880" mass="96405" checksum="BF43E2B19DD72D4D" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TV03</accession>
    <name>A0A433TV03_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_006850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000171">
        <property type="protein sequence ID" value="RUS85407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TV03"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS85407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="318" mass="34588" checksum="03F7F880191E43D6" modified="2019-05-08" version="1">MCIANHPCSVSTCIHSQALSSRPLTTHSDQDLIRFDPLRLAALSGLEALTGLSGPLGSPNQSPGQPHLSSASTGSHRHDVTGRHTSLFLALSGWYSRDIVKWFIDIAMKSDKQTRGETRGETATKTAALFTSAGEGGRASKEDDQEIDFCPLVDRSPELFIFTLRNSYSYPEGEGVLRDEQWREGDEAFPMQTISRTRGDVAQIGCGVGLEEFWTDLNRLDLSGTKLSTGMGGVGGTDVKPFQKIPTACLAAPRDKRPRHAFFINRSTAHSRRVIPVQDVVVVVVVVVVVVVVVVVGGDDDDDDDYDDDDDEDVDTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TV50</accession>
    <name>A0A433TV50_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_006790</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000169">
        <property type="protein sequence ID" value="RUS85457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TV50"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005283">
        <property type="term" value="F:amino acid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089718">
        <property type="term" value="P:amino acid import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037979">
        <property type="entry name" value="Na_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF321">
        <property type="entry name" value="SODIUM-DEPENDENT NUTRIENT AMINO ACID TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0769">Symport</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="323"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="460"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="534"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="576"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="11"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS85457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="612" mass="68008" checksum="AD96507E8DC01CCD" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TWR3</accession>
    <name>A0A433TWR3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_006221</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000153">
        <property type="protein sequence ID" value="RUS86009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TWR3"/>
    <dbReference type="STRING" id="188477.A0A433TWR3"/>
    <dbReference type="OrthoDB" id="5873721at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019372">
        <property type="entry name" value="LHFPL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12489">
        <property type="entry name" value="LIPOMA HMGIC FUSION PARTNER-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12489:SF1">
        <property type="entry name" value="LP10272P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10242">
        <property type="entry name" value="L_HMGIC_fpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="226"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="253"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS86009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="267" mass="29856" checksum="F1FE04446A08B5EC" modified="2019-05-08" version="1">MMDPKFNPETAKVYHFRYMREYRAVAVLWAVLTMIWCILNVVCFIQPQWIGDTKESAGNGHFGVYARCVPDQDRARYVCKGDFTNFNTILNDEFKAATFFCGVSALLMLICVAALLLFFCFKKAAVFVFCGIIEVICAIFMFIACVIYPAGWDEPEVQSICGEGAGQYDLGDCDIRWAYILAILGIFDAGILALLAFFLASKRAKIEIYSTAGTVTKSELNGYSETMSKKSGPIQPQVVAVPADGDHDRQSEYSRYSQPRSRSGFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TWY6</accession>
    <name>A0A433TWY6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_006134</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000150">
        <property type="protein sequence ID" value="RUS86114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TWY6"/>
    <dbReference type="STRING" id="188477.A0A433TWY6"/>
    <dbReference type="OrthoDB" id="9990906at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF25">
        <property type="entry name" value="CNMAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="477"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="8">
        <location>
            <begin position="158"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS86114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="547" mass="60938" checksum="88EF7BE42388AB5D" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TXQ8</accession>
    <name>A0A433TXQ8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_005902</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000142">
        <property type="protein sequence ID" value="RUS86317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TXQ8"/>
    <dbReference type="STRING" id="188477.A0A433TXQ8"/>
    <dbReference type="OrthoDB" id="26242at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00102">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019018">
        <property type="entry name" value="Rab-bd_FIP-RBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51511">
        <property type="entry name" value="FIP_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="FIP-RBD" evidence="3">
        <location>
            <begin position="451"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS86317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="523" mass="56987" checksum="6EFEBD39F2BA346D" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TYI2</accession>
    <name>A0A433TYI2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_005628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000133">
        <property type="protein sequence ID" value="RUS86612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TYI2"/>
    <dbReference type="OrthoDB" id="6045352at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS86612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="371" mass="41170" checksum="B09E792CC180B2D6" modified="2019-05-08" version="1">MAATDSSVTTDEISHLVEKKRDQGSHECEVLGTSSHEAEESSLAWQMCTKNPGHHQFIPAAEFSLDKLPQWCRKPLVLDYVKYMCATTVRLKVGYTSWDRPDGYCFSSCRGTSLAHFGSGHLIAMSQHDGPCQCPECESSPSPHQTCHKLYIATAQHVVFNTEEAKATQVSFFYDDEASGTDGRVKIVWGTRGGSKGHEGDNSIFMCVTHDETLVSELKQIQAQYKHLKFKFEGQAGTSPNIDWKNLCVVVSHPHGQPKKITVGEMKSCTGAGTCNRRQFSYSTATCRGSSGAFVLSLEFYEAMPYVSWYTGMMWGAAHSFGGLNGEYNKSAYSNPDVADFFTPISVRLPRSMLWLLGGTWMKSVWCLVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TZ24</accession>
    <name>A0A433TZ24_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">CD109 antigen</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">EGW08_005432</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">EC2010</strain>
            <tissue evidence="19">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Modulates negatively TGFB1 signaling in keratinocytes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Heterodimer; disulfide-linked. Interacts with TGFB1 and TGFBR1. Forms a heteromeric complex with TGFBR1, TGFBR2 and TGFBR3 in a ligand-independent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000127">
        <property type="protein sequence ID" value="RUS86836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A433TZ24"/>
    <dbReference type="OrthoDB" id="9998011at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02897">
        <property type="entry name" value="A2M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000001">
        <property type="entry name" value="CD109 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1930:FF:000001">
        <property type="entry name" value="CD109 isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000155">
        <property type="entry name" value="complement C3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.130.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1930">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.690">
        <property type="entry name" value="Alpha-macroglobulin, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009048">
        <property type="entry name" value="A-macroglobulin_rcpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036595">
        <property type="entry name" value="A-macroglobulin_rcpt-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011625">
        <property type="entry name" value="A2M_N_BRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041813">
        <property type="entry name" value="A2M_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047565">
        <property type="entry name" value="Alpha-macroglob_thiol-ester_cl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019742">
        <property type="entry name" value="MacrogloblnA2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002890">
        <property type="entry name" value="MG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041555">
        <property type="entry name" value="MG3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF136">
        <property type="entry name" value="CD109 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07703">
        <property type="entry name" value="A2M_BRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07677">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01835">
        <property type="entry name" value="MG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17791">
        <property type="entry name" value="MG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01359">
        <property type="entry name" value="A2M_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01361">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01419">
        <property type="entry name" value="Thiol-ester_cl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49410">
        <property type="entry name" value="Alpha-macroglobulin receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00477">
        <property type="entry name" value="ALPHA_2_MACROGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0882">Thioester bond</keyword>
    <feature type="domain" description="Alpha-2-macroglobulin bait region" evidence="16">
        <location>
            <begin position="388"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-2-macroglobulin" evidence="17">
        <location>
            <begin position="651"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-macroglobulin receptor-binding" evidence="18">
        <location>
            <begin position="1272"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00069665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RUS86836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1377" mass="150288" checksum="0A819C49E02D52CE" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TZ46</accession>
    <name>A0A433TZ46_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_005386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000126">
        <property type="protein sequence ID" value="RUS86849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TZ46"/>
    <dbReference type="STRING" id="188477.A0A433TZ46"/>
    <dbReference type="OrthoDB" id="8633268at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031396">
        <property type="term" value="P:regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007089">
        <property type="term" value="P:traversing start control point of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039061">
        <property type="entry name" value="MTBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14382">
        <property type="entry name" value="MDM2-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14382:SF1">
        <property type="entry name" value="MDM2-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="643"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="695"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="696"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="713"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="765"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="798"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="853"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="867"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="895"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="920"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS86849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="920" mass="103704" checksum="5BD2E7C565A34F5B" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U0A0</accession>
    <name>A0A433U0A0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_004939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000115">
        <property type="protein sequence ID" value="RUS87259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U0A0"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS87259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="121" mass="13639" checksum="FCA18DA85CE9C167" modified="2019-05-08" version="1" fragment="single">RSVHDDGICSHCRPGGRGCVRPRLWTQSTHSGRGWVVWPAPSRLDFRPDGKLHRLLCGSRRLHPAQRPHSHTNGRHSVTVDRAQGLLVEHTRFESCPDLRDVLSAITENLPFTPIAMLKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U5K5</accession>
    <name>A0A433U5K5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">U4/U6.U5 tri-snRNP-associated protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_003181</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of a tri-snRNP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNUT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000067">
        <property type="protein sequence ID" value="RUS89070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U5K5"/>
    <dbReference type="STRING" id="188477.A0A433U5K5"/>
    <dbReference type="OrthoDB" id="21368at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013957">
        <property type="entry name" value="SNRNP27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077">
        <property type="entry name" value="U4/U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077:SF1">
        <property type="entry name" value="U4_U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08648">
        <property type="entry name" value="SNRNP27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein" evidence="11">
        <location>
            <begin position="96"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS89070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="152" mass="17836" checksum="0F1D51C3A6A6E0F8" modified="2019-05-08" version="1">MPRNRSRSPHSKRDRRGSRSRSRERRHRKKRSRSRSPRHRGSPPRHRSRSPHSPRRLQRSSSPSKHRERDGISVEKGAPEIAVPKIDESKLEGLDDEQVDMMKLMGFANFDTTKGKKVSGNDVSAVNLQRKRRYRQYMNRRGGFNRPLDFIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U7H7</accession>
    <name>A0A433U7H7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_002460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000048">
        <property type="protein sequence ID" value="RUS89757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U7H7"/>
    <dbReference type="STRING" id="188477.A0A433U7H7"/>
    <dbReference type="OrthoDB" id="442860at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032451">
        <property type="term" value="F:demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070988">
        <property type="term" value="P:demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.590:FF:000019">
        <property type="entry name" value="DNA N6-methyl adenine demethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032857">
        <property type="entry name" value="ALKBH4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12463:SF0">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12463">
        <property type="entry name" value="OXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="173"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS89757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="302" mass="33844" checksum="3DBABAE5C9031BAF" modified="2019-05-08" version="1">MEKSCGCKGIRSCRLCEECETGPLHSDKENVTLSLYNFCLDCQRAWSTKNDMSCGFPSDSAVEKQRVDDRCAAETQEASRSCPNICDHTCQSPINFSGVSVIRNFVTKDEEAALCEAIYGTDFVNSQSGRRKQDFGPKVNFKRKKLKLAAFTGLPSYSRFLYDRMKQRTELSDFDPVELCNLEYCSERGAHIDPHFDDAWLWGERLVTLNLISDSTLSFTSDKLPSSEVRVPMPLLSLVIVEGAARHCWKHGISRGDITGRRLAMTFRELSDEFRSGGQKEDEGEQLLKLALTFEGIAVGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U7R6</accession>
    <name>A0A433U7R6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein quiver</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_002410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000047">
        <property type="protein sequence ID" value="RUS89798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U7R6"/>
    <dbReference type="STRING" id="188477.A0A433U7R6"/>
    <dbReference type="OrthoDB" id="6110560at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032222">
        <property type="term" value="P:regulation of synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030431">
        <property type="term" value="P:sleep"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031424">
        <property type="entry name" value="QVR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050975">
        <property type="entry name" value="Sleep_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562">
        <property type="entry name" value="ATILLA, ISOFORM B-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562:SF2">
        <property type="entry name" value="PROTEIN QUIVER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17064">
        <property type="entry name" value="QVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS89798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="15573" checksum="C562F5A2DBF28163" modified="2019-05-08" version="1">MVLEQGFAIKCFVCNSFHQADCADWFDNVTQHLVKCKPYQTKCRKVVQEVWIDDHWDVRYIRQCAIAGEVGRREGRECDEIYGTYNIRVRQCHCDNQDGCNSAPTLNTSLSILLPFLLSLLLYFRPYMSRLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UAV0</accession>
    <name>A0A433UAV0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_001258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000021">
        <property type="protein sequence ID" value="RUS90954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UAV0"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS90954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="150" mass="15774" checksum="0567233DFFEB3774" modified="2019-05-08" version="1" fragment="single">MFLCKFPTLLTPDLAAPEELTVAVVHLLLDKRLVAPPTAHELAAVQARAVLLTLATAGAQGALLGLVLAEVRRLSQVDEVLLGGALVEVGDALQPGSGVVPAYHARAVKLVLEQAADAAEWLHLAPAHLHGAVPRDAVALAHDPHLFFHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UBA3</accession>
    <name>A0A433UBA3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_001142</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000018">
        <property type="protein sequence ID" value="RUS91117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UBA3"/>
    <dbReference type="STRING" id="188477.A0A433UBA3"/>
    <dbReference type="OrthoDB" id="8862460at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21608">
        <property type="entry name" value="KINESIN-LIKE PROTEIN CG14535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21608:SF7">
        <property type="entry name" value="KINESIN-LIKE PROTEIN CG14535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="7">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="95"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS91117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="238" mass="25422" checksum="20E3CAF5E349DD96" modified="2019-05-08" version="1" fragment="single">MLKICMPGGGQGQGEQGSSFLSADPRKKQVTVFDPSASGYVTSANRKAGTSAPKIFAFDSVFTPDDSLTELCASSLTDTVQSVVAGADGCLFTYGYSRLGKTYTMLGTDRGPPSQLGVMPCALAWLFRLITEQRERTGARFSVRVSAVQLSGREEKLHDLLADIGQGAEARGVGAAPSVYLREDPISGTQLENQSELRAPTAEKAAFYLDAALAARAAADEEECRSSHLLFTVNVYQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z9J1</accession>
    <name>A0A3S0Z9J1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_019681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001053">
        <property type="protein sequence ID" value="RUS72562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z9J1"/>
    <dbReference type="OrthoDB" id="6207208at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="668"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="522"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="681"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS72562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="772" mass="86020" checksum="3E00C9553A505078" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZAZ0</accession>
    <name>A0A3S0ZAZ0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase M12B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_021467</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001338">
        <property type="protein sequence ID" value="RUS70765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZAZ0"/>
    <dbReference type="STRING" id="188477.A0A3S0ZAZ0"/>
    <dbReference type="OrthoDB" id="2131567at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.70.10:FF:000003">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051489">
        <property type="entry name" value="ADAM_Metalloproteinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702">
        <property type="entry name" value="ADAM10/ADAM17 METALLOPEPTIDASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702:SF2">
        <property type="entry name" value="KUZBANIAN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13574">
        <property type="entry name" value="Reprolysin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018631721" description="Peptidase M12B domain-containing protein" evidence="5">
        <location>
            <begin position="22"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="574"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="7">
        <location>
            <begin position="294"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="6">
        <location>
            <begin position="370"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS70765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="679" mass="75052" checksum="26413E5B7FB5F5B4" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZBB4</accession>
    <name>A0A3S0ZBB4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ferric oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_021223</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001287">
        <property type="protein sequence ID" value="RUS71011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZBB4"/>
    <dbReference type="STRING" id="188477.A0A3S0ZBB4"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043020">
        <property type="term" value="C:NADPH oxidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016175">
        <property type="term" value="F:superoxide-generating NAD(P)H oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042554">
        <property type="term" value="P:superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000778">
        <property type="entry name" value="Cyt_b245_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF191">
        <property type="entry name" value="FAD-BINDING FR-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00466">
        <property type="entry name" value="GP91PHOX"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric oxidoreductase" evidence="7">
        <location>
            <begin position="88"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS71011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="196" mass="22248" checksum="05806315434738CD" modified="2019-04-10" version="1" fragment="single">MVDWITNEAPRWLVLSVWIIANIILFVITYLWYLEADEYYYLRRLTGSVSLACARASAACLKLNTMLILLPVCRKLISIIRGSCACCPQPLRRQLDKAITYHQYLAYMICLHSAIHIGAHCFNFENLAEAQRAKGDDLRNYLSRLPFSPNGSWINPIRTTDPEPIQELFKTIAGISGVVITLCLILIVTSSTEIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZBW9</accession>
    <name>A0A3S0ZBW9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_018090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000861">
        <property type="protein sequence ID" value="RUS74151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZBW9"/>
    <dbReference type="OrthoDB" id="6154784at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS74151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="135" mass="15422" checksum="36DC16675494C75C" modified="2019-04-10" version="1" fragment="single">MFPFTSCVSILRRREKPTDWRQINGTLSVAVFTPNNNHNSTNSNKFTTGSSSTCNGGKDTNSRLAIVDEERRGAISFERTDRNAIYIRMLGEYQCAVLCIEPLKETKKKKERNKHHTQIRSFGGWVVVKSTLPIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZC07</accession>
    <name>A0A3S0ZC07_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_016823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000744">
        <property type="protein sequence ID" value="RUS75412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZC07"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS75412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="139" mass="16495" checksum="D30F5195F048B2B8" modified="2019-04-10" version="1" fragment="single">LSIYLSIYLSIYLSIYLSIYLSIYLPIYLSIYLSIYLSIYLSIYLSIYLSIYLSIYLSIYLPIYLYLILDICIGILIYLSIIYLSIYLLSIYLSIYLSIYLSIYLSIYLSIYLSIYLSIYLSIYLSIYLSIYLSIYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZCI5</accession>
    <name>A0A3S0ZCI5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SOCS box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_020416</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001153">
        <property type="protein sequence ID" value="RUS71831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZCI5"/>
    <dbReference type="STRING" id="188477.A0A3S0ZCI5"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03587">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="169"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="4">
        <location>
            <begin position="296"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS71831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="341" mass="38403" checksum="C5083D81CF559913" modified="2019-04-10" version="1">MNNTLVGIEGATSPLMLGPAYPMNMGNVNMPHKDSPTRVLEYKQSQSTTFETSNRYVQSFLCYELFAAIEVGSLTRVRNVLLSYPDLDFNFHIKDVTPLSLTLYRRRFDIFHLFLRHQAKIGNLNLNMISKDSLGRMEPPIITACRLHFLEGVVTLVRKGADIDMTDNQGHTALWVASRQQMPDLVEYLINNGASVSKTDKFHCTPLLAGLMYRVSSMIIRHLIIHGSPLSAPIRWSSPEQSPLFWATKNGNVEIVKLILQAGVGLWEVRSVRMALSNNDVDCEILGVLDSETQLPPSLQHQCKLVVRDCIRQCGHGKSFVKNMQTLPLPPSIIQFLLLCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZDP4</accession>
    <name>A0A3S0ZDP4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_016965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000756">
        <property type="protein sequence ID" value="RUS75273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZDP4"/>
    <dbReference type="OrthoDB" id="6154668at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS75273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="122" mass="13702" checksum="89C06EC61192F239" modified="2019-04-10" version="1">MAASSTVNIEITLLDGKKENISHSIAKENGDISFPGLLNSINFVQEKCNQLLTKIIEDEKSKRANLKLRPKDVPENENLIGDEKGEDDDDDDDNDEDEDDDDDDDDDDEITSTEPPEKKHKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZEQ8</accession>
    <name>A0A3S0ZEQ8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_015014</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000598">
        <property type="protein sequence ID" value="RUS77222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZEQ8"/>
    <dbReference type="STRING" id="188477.A0A3S0ZEQ8"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01388">
        <property type="entry name" value="HMG-box_SoxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000002">
        <property type="entry name" value="transcription factor Sox-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022097">
        <property type="entry name" value="SOX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF324">
        <property type="entry name" value="SOX DOMAIN-CONTAINING PROTEIN DICHAETE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12336">
        <property type="entry name" value="SOXp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="8">
        <location>
            <begin position="113"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="6">
        <location>
            <begin position="113"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="21"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS77222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="325" mass="34692" checksum="23B0BEB521C837DC" modified="2019-04-10" version="1">MNNHSIESIVVDDVRRAARETILTPQSLPELSPTGSGGHPGHSHLHPHHAHHGSNSHLDIHHGHHRMASPCSDDTGRRSLSPASPSSLTHHDDIGGMAGSGGSSLGGGNMDHVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLTEEEKRPFIDEAKRLRALHMKEHPDYKYRPRRKPKSLMKKDKYAFPLHPGMLGPAGMNGGMNAALGSHPMDVVGSPLATSNASSSPPASSSSTTVSSASALTLSALRHHDALAASSLYSPYLAAAAAVAQGHHPHPHLAGLPPSAAHAHATAAAAGMGQYLLPDLNPSRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZH04</accession>
    <name>A0A3S0ZH04_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_017588</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000811">
        <property type="protein sequence ID" value="RUS74655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZH04"/>
    <dbReference type="STRING" id="188477.A0A3S0ZH04"/>
    <dbReference type="OrthoDB" id="74807at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21437">
        <property type="entry name" value="zf-HIT_ZNHIT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039723">
        <property type="entry name" value="Vps71/ZNHIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13093">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="6">
        <location>
            <begin position="120"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS74655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="157" mass="17946" checksum="1270715C4A493DBF" modified="2019-04-10" version="1">MADKRESVRIKDGQQMRILDEAARRRRQRKALEALEKDNFSEDPHADLKMSKKAPKFEEVMETASTSGPKKKRKSRGDFKLRYRKSFAALLEEEHMLNKDGPSYITACAPPSKFPDRHFCAVCGFPSAYTCVQCGARYCCVKCLGTHQDTRCLKYTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZHK5</accession>
    <name>A0A3S0ZHK5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_014413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000549">
        <property type="protein sequence ID" value="RUS77820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZHK5"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS77820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="308" mass="32598" checksum="FC62718DBF36F2AC" modified="2019-04-10" version="1" fragment="single">GPDGRALHDRSKSVPLIPNDILAHVQTFREQQLKKGQKENNERAPMLKSFSQGAEPSPPLPPNHPTAGKSELHEITQALRHNRKLSQPNLTETDQVHLPNSAQWGQAKPNAATSSTLLRGGKTTGNTAKPVSSRQRDPAQDDVAFIQMESVPESETSPTPSDDLGSKRSSFSQGEPSSAVDELAAITAMVTKQPFALKKGPQVAPKPSPGGAVSKVVEPAGAGADTKQKPSTMKAPLHNIATESFKKRLGNLMTGSTTSLPTPMAGGTVVPPQGNSSAGAAYPATSDLYEDISHYQNAREISATTRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZIW2</accession>
    <name>A0A3S0ZIW2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_016485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000714">
        <property type="protein sequence ID" value="RUS75759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZIW2"/>
    <dbReference type="OrthoDB" id="10252017at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043:SF8">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="212"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS75759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="29399" checksum="3CC72CD94EAEF68F" modified="2019-04-10" version="1">MAREEVVAHIRPLAPNVPNRVANTVPATTKPVTLGVGCVFTAALWAMEDCFVKPVQCREGTYGSRCSKSCSKTCAGIHTDCDIVNGTCLLGCVDGYLGDLCDQKCREGTYGSRCSKSCSKTCAGIHTDCDIVNGTCLLGCVDGYLGDLCDQICPEGTYGADCSQKCSPNCAGINSLCVHTNGLCRFGCKKGFYGSRCDKGRNKKLSGGLKINNNNNNNNNNNNNNNNDGDGDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDGDGDDGDDDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZM28</accession>
    <name>A0A3S0ZM28_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_010067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000299">
        <property type="protein sequence ID" value="RUS82185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZM28"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS82185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="104" mass="13320" checksum="C2A17B7ABA9E883A" modified="2019-04-10" version="1" fragment="single">QQINEYTTIKQYFVYQQINEYTTIKQYFVYQQINEYITIKQYFVYQQINEYITIKQYFVYQQINEYTTIKQYFVYQQINEYTTIKQYFVYQQINEYTTIKQYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZNF9</accession>
    <name>A0A3S0ZNF9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_020709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001201">
        <property type="protein sequence ID" value="RUS71524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZNF9"/>
    <dbReference type="OrthoDB" id="411632at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS71524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="156" mass="17507" checksum="6A3F09E5A938748F" modified="2019-04-10" version="1" fragment="single">GLFKPLLKETVHKKNAPFTLELPDKFNRSKIGLSEVGPGDKISKLRPWEIIQKDLVWTAGGFVLGTKEKMQEFITSYKSAQDELLEHDMISADMHTISAIYTPQMIKRGPPEAKAYICRDGWFGIRGTVTKYGCLAFLCKEAAETRAKAKMKSQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZNQ9</accession>
    <name>A0A3S0ZNQ9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_008939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000249">
        <property type="protein sequence ID" value="RUS83317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZNQ9"/>
    <dbReference type="OrthoDB" id="10683098at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS83317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="286" mass="31488" checksum="63286C76C3E1BC81" modified="2019-04-10" version="1" fragment="single">MDDLQTSKSKKARRRSLRNIRRSSNFMPTVSVSYLEPNVLEDGNKGDVSTIIHSYGSAWLGDENVDPLVELNKPLVLEQNLSPTFHSDEIVKTGKSDGDWSPVLCLPANEQVQSRLDKPVVEERSLADSVLHSNYDKNGGIEKHRSCVSPVSVERHGSISSVSDSLPDLDLSLYGSVEDWLNPCSKSRGAFDSPNMAPSTKDCLNEAFMDNFQGILKTAEEIESGNVVNNLKFDSPVSKVDEVCLPSPVSDVEMQPCEREACESSSASSPKFRKVAPRNETDSRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZPV8</accession>
    <name>A0A3S0ZPV8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chitin-binding type-4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_019736</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001060">
        <property type="protein sequence ID" value="RUS72508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZPV8"/>
    <dbReference type="STRING" id="188477.A0A3S0ZPV8"/>
    <dbReference type="OrthoDB" id="64893at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21113">
        <property type="entry name" value="AGAP001705-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21113:SF4">
        <property type="entry name" value="CHITIN-BINDING TYPE-4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018763570" description="Chitin-binding type-4 domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-4" evidence="2">
        <location>
            <begin position="24"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS72508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="302" mass="33742" checksum="8729F6BF2A74589A" modified="2019-04-10" version="1">MTLSVFFTSSFLALLLLPAHVKGHGRLLEPPSRASLWRLGYSAPVNYNDNQLFCGGVGVQYGVNEGKCGVCGDPWNGKREHEAGGRYANGLIVRNYEVGQVINATVELTANHKGFFEFRLCPTDNPFKRVTAHCLQKFPLVVADTGLTRFTVPSGDSYSKITVPLRLPADVRCSACLFQWQYTAGNSWGISQDGRQCVGCGNQEQFYGCADIAIGHKEVAVGKPTPKHPWFFQSEKEKEEWHFGVVRYIKDSQETVDYRSGAKRIIFTTLGLHWMNQDDSIQMITSPSILILVRFVLHWASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZQ94</accession>
    <name>A0A3S0ZQ94_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulfatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_009036</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000253">
        <property type="protein sequence ID" value="RUS83225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZQ94"/>
    <dbReference type="STRING" id="188477.A0A3S0ZQ94"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16029">
        <property type="entry name" value="4-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047115">
        <property type="entry name" value="ARSB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342:SF274">
        <property type="entry name" value="ARYLSULFATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018781811" description="Sulfatase N-terminal domain-containing protein" evidence="7">
        <location>
            <begin position="26"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="37"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS83225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="526" mass="58781" checksum="88FD3E58E0F82181" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZRK0</accession>
    <name>A0A3S0ZRK0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_018615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000916">
        <property type="protein sequence ID" value="RUS73626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZRK0"/>
    <dbReference type="OrthoDB" id="6156745at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS73626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="411" mass="45881" checksum="C577B7C2B98420DB" modified="2019-04-10" version="1">MDFIQALKDAEAAGISQQQFYTIWEQETRMKQMENELRLQQMKTYTGKAQAPEGESSIINLIDSRLQMFSIDQRQVQARMREELQKQNQALIADISRLLEGFASQVGRIVKNELHTVLEEVSLSTSKTNINNSSSYPADFVQAPLWSGGMDQGLTTAWSNVHEHAPNNQDQFTVGNLKEPAHENVVVETANGTGVEGVEGLNKLQAIQKKSRPGSQPSQVVGNHEASHEQMDVIKPSFSSLFDGNNSKTISSPGVHFIPEDRPANMMVFDVSKLSQSGKINKSPIFNLHDCPCKVQLSFWSSAKKELKMCVTFWGLSPQPLKVPKILTVSGMVKNWNSVEYTSLFSVNSPPMNLQAQWSRSIELPLILKTSRGHYPNITVETLSKRGYVCPSRDCVSINWTVVSQNYTCTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZSW2</accession>
    <name>A0A3S0ZSW2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_007195</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000184">
        <property type="protein sequence ID" value="RUS85058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZSW2"/>
    <dbReference type="STRING" id="188477.A0A3S0ZSW2"/>
    <dbReference type="OrthoDB" id="6156630at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018749555" description="Ig-like domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="15"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS85058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="179" mass="19672" checksum="44E6E13A3F9ACCDF" modified="2019-04-10" version="1">MLPITALASLLLIGPALLLSARGELDVEPVELAVESGEDAEFSCVWSGEDNATKLETVTWYRRTASAASTAVVQELLVTNSYRVRVDNGVLTIQNVTVADRGQYVCRDDSSAVSTEADLIVYDMPGYWLEMGVVIGVAGLLLVIAVLLLMRQRTRRIRPQKQKTRRFKQMVSADAEKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZT38</accession>
    <name>A0A3S0ZT38_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_006113</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000150">
        <property type="protein sequence ID" value="RUS86093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZT38"/>
    <dbReference type="STRING" id="188477.A0A3S0ZT38"/>
    <dbReference type="OrthoDB" id="10067927at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026523">
        <property type="entry name" value="PNMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23095">
        <property type="entry name" value="PARANEOPLASTIC ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23095:SF43">
        <property type="entry name" value="PARANEOPLASTIC ANTIGEN-LIKE PROTEIN 8C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="282"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS86093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="307" mass="35028" checksum="A4F79A649B921EBB" modified="2019-04-10" version="1">MSVAEEDRPKTAFCFPCTPNTWRCEQGCSWLYREKNPVGKMAEGQPRNMFYDMNVTTFNGASPFEDFEQEVRALLRARPGLSAEQQKDLVYRHLGRDVRRELACQPSIDSGVDLLKCLAKVYGDMRPLNTLAMEFYGCRQGVYETSRHYSHRLNKVLLSLKTGHTRENAGPVPDMLLRDQFVAGLRSESLRLHLVQHRLANADTTFLETREFALQLSSEETEKSLPCQAAMVAQHVRAQAAQATPPSDLQRVLDKLSTLTERLERLEERDRRPRGRRPDMTCHRCQRPGHFARECRAPAPAGNANPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZTW9</accession>
    <name>A0A3S0ZTW9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_009522</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000275">
        <property type="protein sequence ID" value="RUS82685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZTW9"/>
    <dbReference type="STRING" id="188477.A0A3S0ZTW9"/>
    <dbReference type="OrthoDB" id="8907274at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03384">
        <property type="entry name" value="PAP2_wunen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF103">
        <property type="entry name" value="PHOSPHOLIPID PHOSPHATASE HOMOLOG 1.2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="117"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS82685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="274" mass="31618" checksum="E95AA9B825ECB1AD" modified="2019-04-10" version="1" fragment="single">MPRKMCPQMKCTTICCIFVEVTIILSVAILSVSMRKLLTPNKRGFFLNDKSISHPYRGSSVPDYMLYTTGFLVPVFMMFVIEAFFIRRRMDNHRIHRFLPEVPSKFTFWSWRCYQLLAIFTFGAASTHFLTNLSKYSVGRLRPHFLDVCKPNLILINDTSRYIDEDVCTGDPDRITEARLSFPSGHSSMSMYCAVFFILYLQKRFTFSGIFLLRPLFQVAIFGVGVYTGLTRITDYKHHWDDVLAGGVLGILLAILTMHRILEVAYKTKRDPDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZWN7</accession>
    <name>A0A3S0ZWN7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-mRNA-splicing factor RBM22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">RNA-binding motif protein 22</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">EGW08_003766</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">EC2010</strain>
            <tissue evidence="20">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SLT11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000081">
        <property type="protein sequence ID" value="RUS88508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZWN7"/>
    <dbReference type="STRING" id="188477.A0A3S0ZWN7"/>
    <dbReference type="OrthoDB" id="10259600at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12224">
        <property type="entry name" value="RRM_RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000137">
        <property type="entry name" value="pre-mRNA-splicing factor RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048995">
        <property type="entry name" value="STL11/RBM22-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057674">
        <property type="entry name" value="Znf-CCCH_RBM22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF6">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21369">
        <property type="entry name" value="STL11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25584">
        <property type="entry name" value="zf-CCCH_RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="10 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="19">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="18">
        <location>
            <begin position="233"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="16">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="307"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="324"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="354"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="465"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RUS88508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="475" mass="52246" checksum="88E480FFB47115AC" modified="2019-04-10" version="1">MATSKGANTYNRQNWEDAEFPILCQTCLGDNPYIRMMKEKYGKECKICARPFTVFKWCPGARMRFKKTEVCQTCSKMKNVCQTCLLDLEYGLPVQVRDAALKLQDNMPKSDVNKEYYTQNMEREIANSDGISPVGALAGKAQTPSDMLLKLARTTPYYTRNRPHICSFWVKGECKRGQECPYRHEKPTDPDDPLADQNIKDRFYGMNDPVAHKLMNRYSSLPKLEPPEDRNVTTLYVGNLGDKVTEKDLRDYFYQYGEIRSINVAKQQCAFVQFTSRIAAETAAEKAFNKLIINGRRLNIKWGRPQGQQALAGKEDKEGQPQPTLQPVPGLPQALPMPPEELTNNYFNLAGPAPSGPGGPGPGPPPFMPGPPRGPPRGPPPRFPHIMRGPPPPMPFGGMPRGPPPPGMRLPPPPPGVLPVRPPPGMPPGPPPAHAIRGPRPVHYPSQDPTRMGAVKGGGPPPTSSAPSGADASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZWQ2</accession>
    <name>A0A3S0ZWQ2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutamine synthetase</fullName>
            <ecNumber evidence="3">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_007401</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="3"/>
    <dbReference type="EMBL" id="RQTK01000191">
        <property type="protein sequence ID" value="RUS84860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZWQ2"/>
    <dbReference type="STRING" id="188477.A0A3S0ZWQ2"/>
    <dbReference type="OrthoDB" id="1936100at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000011">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050292">
        <property type="entry name" value="Glutamine_Synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852:SF57">
        <property type="entry name" value="GLUTAMINE SYNTHETASE 2 CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS catalytic" evidence="9">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS84860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="151" mass="16643" checksum="A67F0D284EBC979A" modified="2019-04-10" version="1" fragment="single">QWEFQVGPTAGTRVSDDLWLARYLLHRLSEEFGLAVSFHPKLIPGASGACGGHVNISTASMREEGGIRHIKAAIPRLERTHTQFLSLCDAHGGADNQARLIGFFCTASGNFTYGVENRDACVRIPRQVALDKKGFLEDRRPASNFDPYLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZWQ7</accession>
    <name>A0A3S0ZWQ7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_004322</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000097">
        <property type="protein sequence ID" value="RUS87906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZWQ7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS87906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="346" mass="36494" checksum="A8B7D3FACC4795CD" modified="2019-04-10" version="1">MGSPVTQIPKERLSASPVALLSSPERRTCKSLASELLTSLDAPTIDCGRIVLLEKLDDGVDSGTKARQFRSRSSSWGRKRKGNNSRKPEVRRVSESCIRLPEVKSVIGGTGVTSSSSESHSLATLSLNFHKPHVRSREPDRERCEPDFRFGAAPCRLCVPCRLLGDAVCGLDLDMLLLLSLAVMVVESLPAGVPLPLLLLLLMMLLTALVMAALDDDDDEEAAAVELLAVVVVAAAEAVLMLVASLPSVRTMTGWFVSDDDDDDERGPLEETAGGAMEDDVTPTLPEPALLDTAEGTIVDDGAECGTDDDDDDAGADNDDADCVAEGSDEDDGADAVFAAAAAASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A250</accession>
    <name>A0A3S1A250_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_003606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000077">
        <property type="protein sequence ID" value="RUS88647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A250"/>
    <dbReference type="STRING" id="188477.A0A3S1A250"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48209">
        <property type="entry name" value="AGL056WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48209:SF2">
        <property type="entry name" value="FI24008P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS88647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="221" mass="24779" checksum="2862233E7FE58100" modified="2019-04-10" version="1">MGRTLENGEDHTQNPVPSYFSSIEPLAVPPMNSENVGIISAPNSSRSGSRVPSEYDVTPERAETRKRDDDGDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDYDDHNGDNMTLGLRFLIKNMMTQAHIIKDWNNFKESDDEHLVAILAAMSTSKQNKNKISYTSAPQRLVCCIDGIPTDIIRDALRALASVERCPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A566</accession>
    <name>A0A3S1A566_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_001257</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Secreted</location>
            <location evidence="1 9">Extracellular space</location>
            <location evidence="1 9">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Wnt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000021">
        <property type="protein sequence ID" value="RUS90953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A566"/>
    <dbReference type="STRING" id="188477.A0A3S1A566"/>
    <dbReference type="OrthoDB" id="5945655at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19338">
        <property type="entry name" value="Wnt_Wnt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2460.20:FF:000001">
        <property type="entry name" value="Wnt homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009143">
        <property type="entry name" value="Wnt6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043158">
        <property type="entry name" value="Wnt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018161">
        <property type="entry name" value="Wnt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF99">
        <property type="entry name" value="PROTEIN WNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00246">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 9" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS90953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="329" mass="37565" checksum="B83571A27F4CFE79" modified="2019-04-10" version="1" fragment="single">YLGVASSYQILADEVRYRSDTQCEELPYLQPHQRAICGDDERLLDVIREGAAMGIQECQHQFQDRRWNCSTFSNDTSVFGPVLHTQSRETAYIYAISSAGITYSVTSACSKGELTKCGCDKRAPRWQPAEGFEWGGCSDNVRYGARFSKKFVDSDETKRNERGSMNLWNNGAGRKTVKEEMRIVCKCHGVSGDCSVQVCWRKMKPFRRIGSLLKNKFDGASVHKPEQGNSRARLKRITNLHKRPTKKDLVYLRESPDFCEHKPEQGSLGTRGRQCKKDSPGLDGCKLMCCGRGYQTLIEEEVHDCDCKFLWCCEVRCKQCRKLTEKHYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A7V8</accession>
    <name>A0A3S1A7V8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_007438</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000192">
        <property type="protein sequence ID" value="RUS84823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A7V8"/>
    <dbReference type="OrthoDB" id="10064156at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS84823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="183" mass="19592" checksum="20EB63910359CB63" modified="2019-04-10" version="1" fragment="single">VVPSSQAPVAVKKRQLQLQPLASCPTDQFLYTANNRCYYLPRTCPPGAVPNPSVGCQCGQGQIYNGATGECQISSLQMTCPSGQFFDTISNNCYPLPQVCPVGAVYDPALGCRCWQDQVYSAATGQCQQINPQRPCPNGYYLDLSNNNCYSLPSVCPPNSAPDLDLGCRCPSGLMYNGGTGQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1ABT0</accession>
    <name>A0A3S1ABT0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Polysaccharide biosynthesis domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_004447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000101">
        <property type="protein sequence ID" value="RUS87782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1ABT0"/>
    <dbReference type="STRING" id="188477.A0A3S1ABT0"/>
    <dbReference type="OrthoDB" id="10248897at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3560.10">
        <property type="entry name" value="yst0336 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023139">
        <property type="entry name" value="PBDC1-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008476">
        <property type="entry name" value="PBDC1_metazoa/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021148">
        <property type="entry name" value="Polysacc_synth_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410:SF9">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04669">
        <property type="entry name" value="PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polysaccharide biosynthesis" evidence="1">
        <location>
            <begin position="34"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS87782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="175" mass="20180" checksum="8664620AEECF34BC" modified="2019-04-10" version="1">MAFSMSNLNASELQNVGAVLTSTKASDYTNSADIELQWAMKAMDHATVHYNLISSVDASRLRLTQMDDIIYKHFRETFPDFDVRSIKEDDLKTPESKEKWRNFCESFKGHIEDYNLGTLLRLRCEDDYTPETTTFSVRTQFLAIEIARNKEGHNSILLEKKKAKQEVEAKEKESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1ABY1</accession>
    <name>A0A3S1ABY1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_004329</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000097">
        <property type="protein sequence ID" value="RUS87913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S1ABY1"/>
    <dbReference type="OrthoDB" id="6515930at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000173">
        <property type="entry name" value="Neurogenic locus notch protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.10:FF:000018">
        <property type="entry name" value="Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001759">
        <property type="entry name" value="PTX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049:SF22">
        <property type="entry name" value="DROSOPHILA CRUMBS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00159">
        <property type="entry name" value="PTX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51828">
        <property type="entry name" value="PTX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0768">Sushi</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1227"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="12">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="12">
        <location>
            <begin position="97"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="12">
        <location>
            <begin position="166"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="11">
        <location>
            <begin position="238"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="12">
        <location>
            <begin position="406"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="769"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="839"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="930"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="domain" description="Pentraxin (PTX)" evidence="13">
        <location>
            <begin position="972"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1259"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1340"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1464"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1259"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1303"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1340"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1357"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1489"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="408"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="800"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="848"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="867"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="957"/>
            <end position="966"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS87913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1514" mass="166110" checksum="9BC1F5B131844152" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AD39</accession>
    <name>A0A3S1AD39_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_003452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000073">
        <property type="protein sequence ID" value="RUS88822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AD39"/>
    <dbReference type="OrthoDB" id="6114936at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS88822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="300" mass="31765" checksum="F2D3AB695FC93951" modified="2019-04-10" version="1">MAPTEGANGRLASTWDSDSASPSPPQSPRNPQKSAPCSPKRDPLELSLSLQDLDNTCEIYFCGWDTSLSPPTSTRHLTVPEASADFKRAMVTPEHLEKPHLSRTPSPTLPPVTACSRKSACSTSRSLSSSRTPSPMSLSPPPLSPTWSSSVSSLCSSSLLSSSPSSPSTPSSSPKPTLKAALSLVLSPLKAEKTPKRSRSKPWQGGVFLPSIVSSSDSITPGPLATRRPASFGDADGVKYRNTHRRASHGEKHVSWADEFGSTSKLTSVRLIRPRLDAADSKKSGAPTPGRSILRDTGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AYE9</accession>
    <name>A0A3S1AYE9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_016818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000744">
        <property type="protein sequence ID" value="RUS75407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AYE9"/>
    <dbReference type="STRING" id="188477.A0A3S1AYE9"/>
    <dbReference type="OrthoDB" id="10067843at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044666">
        <property type="term" value="C:MLL3/4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030331">
        <property type="term" value="F:nuclear estrogen receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902808">
        <property type="term" value="P:positive regulation of cell cycle G1/S phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033148">
        <property type="term" value="P:positive regulation of intracellular estrogen receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028213">
        <property type="entry name" value="PA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28467">
        <property type="entry name" value="PAXIP1-ASSOCIATED GLUTAMATE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28467:SF1">
        <property type="entry name" value="PAXIP1-ASSOCIATED GLUTAMATE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15364">
        <property type="entry name" value="PAXIP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS75407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="576" mass="58888" checksum="1CABF7419AD5D0A1" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B079</accession>
    <name>A0A3S1B079_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Lysosomal cobalamin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_015538</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LIMR family. LMBRD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000642">
        <property type="protein sequence ID" value="RUS76711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B079"/>
    <dbReference type="STRING" id="188477.A0A3S1B079"/>
    <dbReference type="OrthoDB" id="73273at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072665">
        <property type="term" value="P:protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050854">
        <property type="entry name" value="LMBD1_LysCbl_Transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006876">
        <property type="entry name" value="LMBR1-like_membr_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16130:SF2">
        <property type="entry name" value="LYSOSOMAL COBALAMIN TRANSPORT ESCORT PROTEIN LMBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16130">
        <property type="entry name" value="LYSOSOMAL COBALAMIN TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04791">
        <property type="entry name" value="LMBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="9" id="KW-0170">Cobalt</keyword>
    <keyword evidence="8" id="KW-0458">Lysosome</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS76711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="22220" checksum="B38BEA164FFAE06C" modified="2019-04-10" version="1">MAVSGAVIAAGWIPFIVVLVLIFLFSGFYVRYFMHKYDSEIVITVSAIIALSVTLITSALVPVDIFLVSYMKDHDGSFKDWAQNKTVRDDLEHTVLVTYYVFYGIIAFFLFLLLPFMYFFYEEKDENSTCKARCYASLKYCVVCVIIAVVFLLIGALVPGRTSPKSNSTEWEKIDFLLHDMTQTSNLKTSYLKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B214</accession>
    <name>A0A3S1B214_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_022251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001520">
        <property type="protein sequence ID" value="RUS69985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B214"/>
    <dbReference type="OrthoDB" id="6143051at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018646759" description="WSC domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS69985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="17991" checksum="924805E477FD5364" modified="2019-04-10" version="1">MSSAVVCLLVTYSLMMTARASSAPLDSVFGALLVPDQGSECTPVKLGYEVGDTHVAFPRGCYNSKDGHKIFPKNSVVNLRDDIDWGRWIFDGSAKQIIVMCAKIALQRGDPMFGVEFFGECYTGAQPDLSQGQVTPADGCIRFCSNDVGASGSTFVYDLYEWYTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B3J5</accession>
    <name>A0A3S1B3J5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phytanoyl-CoA dioxygenase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_016996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000759">
        <property type="protein sequence ID" value="RUS75247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B3J5"/>
    <dbReference type="STRING" id="188477.A0A3S1B3J5"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF48">
        <property type="entry name" value="ECTOINE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS75247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="20998" checksum="23AC80191FFB486B" modified="2019-04-10" version="1">MSGIKDWSLEHHPSGKLFEPSKADWATHRLTNEQIDTFWRDGFLNHVPLLSVEQCDAILKEYDIFMSESGPGEAELELLYEFHRNQSGDPTNILMHALGHWRLSPLFHDLVFLPSAVVKASQLLIPDREVKVRFWHDQLFAKPPRHGGVVAWHQDYSYWTRTQPMQHLTVSIYFMTELCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B5A7</accession>
    <name>A0A3S1B5A7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_019922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001082">
        <property type="protein sequence ID" value="RUS72314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B5A7"/>
    <dbReference type="STRING" id="188477.A0A3S1B5A7"/>
    <dbReference type="OrthoDB" id="6437521at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF1">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS72314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="29841" checksum="D206A1ED46EDFF65" modified="2019-04-10" version="1">MTDYMEKGKTITGEYYSGLLKRLRSELVRRRRGKLRNGVLLLHDNAPAHRARQAVETADQCGYEILPHPPYSPDLAPSDFCLFPNLKKSIKGHRFEDIEDAISAVEEWFQAQNDTFYSQGLLKVKDRWQKCVDKKMYDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDENGAMMMTSSVQHSLAWLLLLFVTMATTNKLTLPSLTGAASTPPVVFDRTPTYWQKSDSVDVRGSRSARGVAYSRVIRYVDLNVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B746</accession>
    <name>A0A3S1B746_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Concentrative nucleoside transporter C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_015642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000650">
        <property type="protein sequence ID" value="RUS76600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B746"/>
    <dbReference type="STRING" id="188477.A0A3S1B746"/>
    <dbReference type="OrthoDB" id="6075923at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005415">
        <property type="term" value="F:nucleoside:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008276">
        <property type="entry name" value="C_nuclsd_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011657">
        <property type="entry name" value="CNT_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590">
        <property type="entry name" value="SODIUM/NUCLEOSIDE COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 28 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07662">
        <property type="entry name" value="Nucleos_tra2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Concentrative nucleoside transporter C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS76600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="111" mass="12400" checksum="8A269612834132F2" modified="2019-04-10" version="1" fragment="single">MLTACLISAPAALAISKLIYPEMEKVDFNKQRNICMRDASSPRTGMQAISDGATFSIKLIATIMVNMMAFVSILNLVDTLLIWCGERAGKEDFSFNYVSSYVFYHLSWIMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B7Z9</accession>
    <name>A0A3S1B7Z9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_014999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000596">
        <property type="protein sequence ID" value="RUS77246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B7Z9"/>
    <dbReference type="STRING" id="188477.A0A3S1B7Z9"/>
    <dbReference type="OrthoDB" id="6022762at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036396">
        <property type="term" value="C:RNA N6-methyladenosine methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016556">
        <property type="term" value="P:mRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040427">
        <property type="entry name" value="Flacc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38563">
        <property type="entry name" value="FL(2)D-ASSOCIATED COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38563:SF1">
        <property type="entry name" value="FL(2)D-ASSOCIATED COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="723"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="723"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="747"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="778"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="788"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="809"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS77246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="993" mass="105382" checksum="FE642C01052A80B9" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B8C3</accession>
    <name>A0A3S1B8C3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_014739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000576">
        <property type="protein sequence ID" value="RUS77492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B8C3"/>
    <dbReference type="OrthoDB" id="10428847at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS77492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="206" mass="22427" checksum="B9BFB9D3B936A1DC" modified="2019-04-10" version="1">MHRATASAVYTEPSHLLAEDEWKAAPTQVSSFRTVSEKVPQGLREGYGICRDGSNIQQEHLGGSITVQHCGRGPNLKSYKVPKGLREGYGICRDGSNIQQEHLGGSITVQHCGRGPNLKSYKVPKGLREGYGICRDRSNIQQEHLGGSITVQHCGRGPNLKSNKVPKGLREGYGICRDGSNIQQEHLGGSITVQHCGRGPNLKSYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BAD9</accession>
    <name>A0A3S1BAD9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_013399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PCP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000486">
        <property type="protein sequence ID" value="RUS78857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BAD9"/>
    <dbReference type="STRING" id="188477.A0A3S1BAD9"/>
    <dbReference type="OrthoDB" id="252964at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052142">
        <property type="entry name" value="Calmodulin_Regulator_PCP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15359">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15359:SF8">
        <property type="entry name" value="PROTEIN CBG01055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS78857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="135" mass="14995" checksum="73051C53115E4525" modified="2019-04-10" version="1" fragment="single">DPATEKAAVKIQASFRGFQTRRDMSEKKEGEKAQEPSAETPAQAEQKQAQEEEEVDIDLEDPEVEKAALKIQAGFKGLKARKELQEKKPAAGTDAVNVQQEEEEVDIDLTDPEVEKAALKIQSQFKGLMSRKSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BAJ2</accession>
    <name>A0A3S1BAJ2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1</fullName>
            <shortName evidence="8">Oligosaccharyl transferase subunit DAD1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_016218</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DAD/OST2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000693">
        <property type="protein sequence ID" value="RUS76013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BAJ2"/>
    <dbReference type="STRING" id="188477.A0A3S1BAJ2"/>
    <dbReference type="OrthoDB" id="445566at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003038">
        <property type="entry name" value="DAD/Ost2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10705">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10705:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02109">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005588">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS76013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="113" mass="12649" checksum="8982386253C15357" modified="2019-04-10" version="1">MSEKLTTVISKFYDEYMASTPKKLKIIDAYLTYVLLTGVLQFVYCCLVGTFPFNSFLSGFISTVGSFVLAVCLRLQSNPQNKTEFSGISPERSFADFIFAHVVLHLVVINFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BC63</accession>
    <name>A0A3S1BC63_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphoribosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_015026</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000600">
        <property type="protein sequence ID" value="RUS77199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BC63"/>
    <dbReference type="STRING" id="188477.A0A3S1BC63"/>
    <dbReference type="OrthoDB" id="10263753at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF45">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 3, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="6">
        <location>
            <begin position="96"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="5">
        <location>
            <begin position="274"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS77199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="42734" checksum="87CC519D9F2DD52A" modified="2019-04-10" version="1">MSQPRSTNGDVVLLYAHPSAHHLARQIETLCGTDRDALSTNGEASGSPSAPSSLSASPPKRPAVNHLKQAFTPLESFDIASRASFLKARHVEFRNTIQWKKFADGFPNVFIEDVKYMAGKDVIFIGSFHSPAVVFEQLSVLYAFPRYLARSFHFILPYFPTGTMERVDTEGQIATAKTLATLLSAIPLSAKGPAQIIIYDIHALQERFYFSDNVIPRLETAIPLLHSKLSMMEGQGEDLAIAFPDDGAYKRFHLLFPGDEERLIICAKRRMEGNKRIVTVKDGDPKGKHVVIVDDLVQTGGTLLECAKALLQGGATAISAYVTHAVFPNQSWKKFTHTVEGAQPAFANFWITDSLPHAPEICAHEPFKLLSLSTVIAENLLGFDLMPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BDF9</accession>
    <name>A0A3S1BDF9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable glycerol kinase</fullName>
            <ecNumber evidence="3">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EGW08_014066</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">EC2010</strain>
            <tissue evidence="17">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>glycerol + ATP = sn-glycerol 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.30"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="3"/>
    <dbReference type="EMBL" id="RQTK01000527">
        <property type="protein sequence ID" value="RUS78178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BDF9"/>
    <dbReference type="STRING" id="188477.A0A3S1BDF9"/>
    <dbReference type="OrthoDB" id="5422795at2759"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07792">
        <property type="entry name" value="ASKHA_NBD_FGGY_GK1-3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000177">
        <property type="entry name" value="Glycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000108">
        <property type="entry name" value="Glycerol kinase, glycosomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042018">
        <property type="entry name" value="GK1-3_metazoan-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000756">
        <property type="entry name" value="PRK00047.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF69">
        <property type="entry name" value="GLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1061"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="15">
        <location>
            <begin position="544"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="16">
        <location>
            <begin position="796"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="135"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="201"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="306"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="341"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="376"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="392"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RUS78178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1084" mass="118084" checksum="AF6859D514D537BB" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BEV6</accession>
    <name>A0A3S1BEV6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">fatty acid amide hydrolase</fullName>
            <ecNumber evidence="3">3.5.1.99</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Anandamide amidohydrolase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">EGW08_009808</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">EC2010</strain>
            <tissue evidence="22">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(9Z)-octadecenamide + H2O = (9Z)-octadecenoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:26506"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:116314"/>
            <dbReference type="EC" id="3.5.1.99"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:26507"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O</text>
            <dbReference type="Rhea" id="RHEA:51316"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:133992"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:51318"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N-(15Z-tetracosenoyl)-ethanolamine + H2O = (15Z)-tetracosenoate + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:63144"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32392"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:146187"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:63145"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine</text>
            <dbReference type="Rhea" id="RHEA:64108"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:59002"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:64109"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:64116"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:149697"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:64117"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + H2O = ethanolamine + (5Z,8Z,11Z,14Z)-eicosatetraenoate</text>
            <dbReference type="Rhea" id="RHEA:26136"/>
            <dbReference type="ChEBI" id="CHEBI:2700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="EC" id="3.5.1.99"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:26137"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N-(9Z-hexadecenoyl) ethanolamine + H2O = (9Z)-hexadecenoate + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:35563"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32372"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:71465"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:35564"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-(9Z-octadecenoyl) ethanolamine + H2O = ethanolamine + (9Z)-octadecenoate</text>
            <dbReference type="Rhea" id="RHEA:45060"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:71466"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:45061"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N-docosanoyl-ethanolamine + H2O = docosanoate + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:63128"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:23858"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:146186"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:63129"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N-octadecanoyl ethanolamine + H2O = octadecanoate + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:63124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:85299"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:63125"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.99" evidence="3"/>
    <dbReference type="EMBL" id="RQTK01000287">
        <property type="protein sequence ID" value="RUS82420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BEV6"/>
    <dbReference type="STRING" id="188477.A0A3S1BEV6"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017064">
        <property type="term" value="F:fatty acid amide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1300.10:FF:000001">
        <property type="entry name" value="Fatty-acid amide hydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052096">
        <property type="entry name" value="Endocannabinoid_amidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45847">
        <property type="entry name" value="FATTY ACID AMIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45847:SF6">
        <property type="entry name" value="FATTY ACID AMIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="20" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="21">
        <location>
            <begin position="100"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="18">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="18">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="18">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="247"/>
            <end position="250"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00077216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="RUS82420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="591" mass="65410" checksum="E85ACEE5E6F0F6BE" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BF96</accession>
    <name>A0A3S1BF96_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Signal recognition particle subunit SRP72</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EGW08_009565</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">EC2010</strain>
            <tissue evidence="15">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the SRP72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000276">
        <property type="protein sequence ID" value="RUS82662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BF96"/>
    <dbReference type="STRING" id="188477.A0A3S1BF96"/>
    <dbReference type="OrthoDB" id="5421607at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000062">
        <property type="entry name" value="Signal recognition particle subunit SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013699">
        <property type="entry name" value="Signal_recog_part_SRP72_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026270">
        <property type="entry name" value="SRP72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031545">
        <property type="entry name" value="SRP72_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094:SF9">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08492">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17004">
        <property type="entry name" value="SRP_TPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038922">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9 11" id="KW-0733">Signal recognition particle</keyword>
    <keyword evidence="7 12" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="216"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Signal recognition particle SRP72 subunit RNA-binding" evidence="14">
        <location>
            <begin position="534"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="522"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="548"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="571"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="618"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="645"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR038922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RUS82662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="658" mass="73463" checksum="0804F6CB3CD435D7" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BGU5</accession>
    <name>A0A3S1BGU5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LicD/FKTN/FKRP nucleotidyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_008921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000249">
        <property type="protein sequence ID" value="RUS83299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BGU5"/>
    <dbReference type="OrthoDB" id="419198at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052942">
        <property type="entry name" value="LPS_cholinephosphotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43404">
        <property type="entry name" value="LIPOPOLYSACCHARIDE CHOLINEPHOSPHOTRANSFERASE LICD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43404:SF1">
        <property type="entry name" value="MNN4P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="2">
        <location>
            <begin position="229"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS83299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="437" mass="51552" checksum="C9F91BADEC44A663" modified="2019-04-10" version="1">MSYLSSALTIDHISTLERCSSYFIKRLILPVKLSAVSFGAHPRYSIPAYFGGQVSANSQHSRSKSKVFPRREGWTRLMESFLPMRRLTRYNGCSSIIRTFLVVFLLVAFIRPLRNALVPMWPKVYREMSTYRVLTMYLEDAFFYVETRPYVGSCSGVHERLLQVRMPRLEEMPVYEMDVWNRHMARVRRSLPPSEFELLDKFKPSMTEQEQRFIMFAMLSATQAMTAFNITHLVRGGSLIGYWRHHGRMPWDEDIDILVDSTQWKLARKVLSCLPDLQLNMDPQHMWKLFHKDAALWKNEKFIRFPYVDLFLYRADEDHVWPLTIWMKMITMKRRHALPPRQGVFEGWPISIPHRPADVLHELYPGRIMADCYSQIFHRRARERVPHKQRIYVPCSMLRGIYPLVVRRLDGGGVVEERMLGSKLLSTFNTTYNGFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BI58</accession>
    <name>A0A3S1BI58_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Apolipoprotein D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_010955</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the calycin superfamily. Lipocalin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000346">
        <property type="protein sequence ID" value="RUS81281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BI58"/>
    <dbReference type="OrthoDB" id="565904at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042246">
        <property type="term" value="P:tissue regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002969">
        <property type="entry name" value="ApolipopD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022271">
        <property type="entry name" value="Lipocalin_ApoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612">
        <property type="entry name" value="APOLIPOPROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612:SF34">
        <property type="entry name" value="APOLIPOPROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08212">
        <property type="entry name" value="Lipocalin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036893">
        <property type="entry name" value="Lipocalin_ApoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01219">
        <property type="entry name" value="APOLIPOPROTD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-0873">Pyrrolidone carboxylic acid</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018384187" description="Apolipoprotein D" evidence="5">
        <location>
            <begin position="23"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="6">
        <location>
            <begin position="85"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR036893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS81281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="227" mass="24349" checksum="64B3738AA22C404F" modified="2019-04-10" version="1">MAIVKSLLSLACALLYLQVSDAQIVIKPGDCPTVVGQSTLETSRYLGTWYEYQRFPAVFELGLECTTAQYGLAANGTINVTNAVFELGLECTTAQYGLAANGTISVTNKGQLRITVFNTKYVVKNSVANGKATVPDPSKPAELSVSFGGFAPPGGKANYIIQETDYENYSVIFSCTQLPGFNVQNAWILTRERGVAPSNLADLESRLSNAGVDLNSFFVVDQSECTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BKZ7</accession>
    <name>A0A3S1BKZ7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tubulin--tyrosine ligase-like protein 12 SET-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_001481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000025">
        <property type="protein sequence ID" value="RUS90770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BKZ7"/>
    <dbReference type="STRING" id="188477.A0A3S1BKZ7"/>
    <dbReference type="OrthoDB" id="60477at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057954">
        <property type="entry name" value="SET_TTL12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027749">
        <property type="entry name" value="TTLL12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46088">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE-LIKE PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46088:SF1">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE-LIKE PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25556">
        <property type="entry name" value="SET_TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin--tyrosine ligase-like protein 12 SET-like" evidence="1">
        <location>
            <begin position="61"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS90770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="617" mass="72150" checksum="627454C0995B5212" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BLV1</accession>
    <name>A0A3S1BLV1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fructose-2,6-bisphosphatase TIGAR</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">TP53-induced glycolysis and apoptosis regulator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_008351</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 2,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17289"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <dbReference type="EC" id="3.1.3.46"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphoglycerate mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000226">
        <property type="protein sequence ID" value="RUS83870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BLV1"/>
    <dbReference type="STRING" id="188477.A0A3S1BLV1"/>
    <dbReference type="OrthoDB" id="354304at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045820">
        <property type="term" value="P:negative regulation of glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043456">
        <property type="term" value="P:regulation of pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051695">
        <property type="entry name" value="Phosphoglycerate_Mutase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517:SF1">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="6">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="13"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS83870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="317" mass="35219" checksum="4413D132F2215102" modified="2019-04-10" version="1">MEKKRLFTVTLVRHGETMHNRDKIMQGQLDTQLSDLGEEQARLVGRRLNDQRFTHAFSSDLSRASNTARKILQENLGTACELTLDRRLRERSFGYLEGRPFTDFKQAQQASGLSQEMFTPEGGETVEQVYHRAKDFFQDLCRLMAEPLKDEAGLNDKDQESSHFSSVTGSQSSLTKKVHSGALTDASNFIDLSPTCSSDSSSFGTQSQSSPFTTKFVNGQDLKEVTDHVLIVSHGLLLRELKRVILEKFHGVLEDAMATEAPVVSPNTGVTSLTLSVNYKYGKVKVTCVECHVINCTAHLCNGKKDLISHALFKGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BM24</accession>
    <name>A0A3S1BM24_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">EIF-4F 25 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_005467</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000129">
        <property type="protein sequence ID" value="RUS86744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BM24"/>
    <dbReference type="STRING" id="188477.A0A3S1BM24"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF8">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS86744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="24344" checksum="B604CF08FD4FD847" modified="2019-04-10" version="1">MAERETDQRVAVIRPAEQEEEEASMGDPDSVIKHPLQNSWAMWFFKNDKTRDWKDNLRVITTFDTVEDFWGLYNHTLPASKLQSGCDYSVFKAGIQPMWEDAQNKKGGRWLINLNKSQRQPHLDDLWLETLLCLIGEGFDEYSDDICGATVNIRTKGDKLGLWTRDASRNDATRKIGIKLKESLNVPPKIVIGFQAHSDTAGKAGSTVKNRFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BMP1</accession>
    <name>A0A3S1BMP1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_007847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000207">
        <property type="protein sequence ID" value="RUS84385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BMP1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS84385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="124" mass="13993" checksum="07E7BACA1A914EFE" modified="2019-04-10" version="1" fragment="single">MGTRALPWTSLTKRPRSLAMKVCPYRLTTMRGLAWRKARASGTASSEPYRARRPNWPLLPSRPPPGDPRLWSSVSRSWWRGSGCSPRFRTLGTLGGLWVEFMVSGFRVLAKIPDAWHPGRAMGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BNQ4</accession>
    <name>A0A3S1BNQ4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Anti-proliferative protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_020964</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BTG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001242">
        <property type="protein sequence ID" value="RUS71272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BNQ4"/>
    <dbReference type="STRING" id="188477.A0A3S1BNQ4"/>
    <dbReference type="OrthoDB" id="19928at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.90">
        <property type="entry name" value="Anti-proliferative protein, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002087">
        <property type="entry name" value="Anti_prolifrtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033332">
        <property type="entry name" value="BTG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036054">
        <property type="entry name" value="BTG-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22978">
        <property type="entry name" value="B-CELL TRANSLOCATION GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22978:SF44">
        <property type="entry name" value="PROTEIN BTG3-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07742">
        <property type="entry name" value="BTG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00310">
        <property type="entry name" value="ANTIPRLFBTG1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00099">
        <property type="entry name" value="btg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160696">
        <property type="entry name" value="BTG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anti-proliferative protein" evidence="3">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="261"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="343"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="384"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS71272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="447" mass="48652" checksum="FEFCD684B084A1EB" modified="2019-04-10" version="1">MKPEISAATEFLSRVFLTHDRVTKEKVAEFKKQLAALLEERYVNHWHEASPTKGQAFRCIRVCPEEALDPVLEKVCHDVGISTGDFQLPIELTLWVDPREVVCKFGDLKCSYHTVAKNNESSGTLDNQAHDLDIDDLVENARELYLKKQSVVIHPINSSEMHIPYTEGSTNGFTMAIRMNGTMHYNMVSMNGANGGSLVNGYDGSPRGKSRAPHSMHHKRGGGVSFHYYGKSSGGKGGSHYLPNGNMSTSSPGGTGSHQGYPHHRNNHNHHHHHHPHHHQAHHHQHHHHHTMGSSPYSNSYLNGYVDENGTGPGYIYDHRSGSPTKMNGLNHPPPPLSGSNGGVSQSSPTPEQIQQQMLHPPPMPPHLQQAFDTSTLPPPPPASSAAVSSSSSPAVTSNINNNSSGSSSNMTTPNGKSTNVSKYPNTRSGGMGGPRNKQGSPAKEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BP27</accession>
    <name>A0A3S1BP27_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromatin target of PRMT1 protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_004084</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000092">
        <property type="protein sequence ID" value="RUS88122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BP27"/>
    <dbReference type="STRING" id="188477.A0A3S1BP27"/>
    <dbReference type="OrthoDB" id="446014at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052656">
        <property type="entry name" value="CTOP_PRMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025715">
        <property type="entry name" value="FoP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48426">
        <property type="entry name" value="CHROMATIN TARGET OF PRMT1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48426:SF1">
        <property type="entry name" value="CHROMATIN TARGET OF PRMT1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13865">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01218">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Chromatin target of PRMT1 protein C-terminal" evidence="3">
        <location>
            <begin position="207"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="250"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS88122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="295" mass="31163" checksum="F912DF1D638BBBD0" modified="2019-04-10" version="1">MTTVPTKIVLKSTTRMSLSERFSHIVPTVQTIRSNMAAEQQVSAANRRLAQQLANRPGVGQAGGGNPAAFMYQQQQQQMMMTGRGGAGGAGFRGNRGSLRGVGANKGTLKQRLGKSNVKNRLTLPAARGTQQFARGGYRGGRGARGGSIQALQGGAGDFTYSKPQGRGGFSPARGRGRGTTFRGRGNFNRSDEVFQFQGGKVGTRKPRGGFTRDRAGFTGQTIVRGGRGQRRGGTFRGGQRGQRGRGGRGGRGASAANGGGSMTAHDLDSQLDEYMSKSKSHLDSELDAYMSQVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BP45</accession>
    <name>A0A3S1BP45_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FERM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_004041</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="RUS88209.1"/>
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    <dbReference type="STRING" id="188477.A0A3S1BP45"/>
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    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Erythrocyte protein band 4.1-like 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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        <property type="entry name" value="Band_41_domain"/>
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        <property type="entry name" value="Ez/rad/moesin-like"/>
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        <property type="entry name" value="PH-like_dom_sf"/>
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        <property type="entry name" value="Ubiquitin-like_domsf"/>
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    <dbReference type="PANTHER" id="PTHR23280">
        <property type="entry name" value="4.1 G PROTEIN"/>
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        <property type="entry name" value="FI22325P1"/>
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    <dbReference type="PRINTS" id="PR00661">
        <property type="entry name" value="ERMFAMILY"/>
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        <property type="entry name" value="B41"/>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="563"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="3">
        <location>
            <begin position="16"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS88209.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="622" mass="70820" checksum="F9648B8FC3EE676C" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BV07</accession>
    <name>A0A3S1BV07_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <dbReference type="NCBI Taxonomy" id="188477"/>
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    <reference evidence="1 2" key="1">
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            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
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                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
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        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000056">
        <property type="protein sequence ID" value="RUS89442.1"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BV07"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS89442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="177" mass="20252" checksum="4567FDD547DED4B5" modified="2019-04-10" version="1" fragment="single">WIKHATGLPFRTISLASIRFIIAWGRVPEPTIGRGAPSPFRWWTASALGRGSTSTFRWWAASAFRRWSPSSIRRWSSSSIRRWSSSSVWGWSSSAIWWWPSSSIGGRTSSSIRRRTSSSIWWWPPSAIWWWPPSTIGWWAAPLIVRPEWFIVHRSLVIALVVSPISTWSLVDSGSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BVC9</accession>
    <name>A0A3S1BVC9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
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        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
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            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
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                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000051">
        <property type="protein sequence ID" value="RUS89634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="188477.A0A3S1BVC9"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS89634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="109" mass="11717" checksum="433E1DC00E510C5F" modified="2019-04-10" version="1" fragment="single">ISLRVPTHVLSVTISLRVPTHVLSVAISLRVPTHVLSVAISLRVPTHVLSVAISLRVPTHVLSVAISLRVPTHVLSVAVSLRVPTHVLSVTISLRVPTHVLTQTLLHLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C3P8</accession>
    <name>A0A3S1C3P8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_010132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000302">
        <property type="protein sequence ID" value="RUS82120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C3P8"/>
    <dbReference type="OrthoDB" id="6134861at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS82120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="207" mass="22650" checksum="30321A0CCBBA889F" modified="2019-04-10" version="1" fragment="single">DCPYGDTALLRGDGSTCAEHIAKYPSACYNNETREICCSSCARLHTGTYACPYGDRRVGCTRDLCDQVLPNGTLLAELCCGTCNYTGPRECRDVTLIDDFTCQERIESYSSQGCYNGTVAFHCCASCSKMRLDIPGCEYGDLIKGGYCGLEANYDYSGCTKRLTPLCCLTCDPDFRNRDGDPDSGVYLSGHLVLTFFTLLLSIMMAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C4H4</accession>
    <name>A0A3S1C4H4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_009492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000273">
        <property type="protein sequence ID" value="RUS82754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C4H4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS82754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="100" mass="12026" checksum="4CE8A486784EA479" modified="2019-04-10" version="1" fragment="single">KNLKKGGLVSKLIIYKECIDVTNKNVCQFQKFPYILTQNNIRLHRKFNPCRPMWYENKAHPKLTRIVGNLICKIGSQMQNCKTWRVYMAKRTNLRRCYYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1CB77</accession>
    <name>A0A3S1CB77_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_004281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000095">
        <property type="protein sequence ID" value="RUS88003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1CB77"/>
    <dbReference type="OrthoDB" id="6074891at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS88003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="252" mass="27707" checksum="274D829AE359AAAB" modified="2019-04-10" version="1" fragment="single">PRRGVLQKTISCLREVHERCSGNARRLQELDMLFSIEAWRRGRALLCGDLNLFKEHFECVSQFGPRISACILLKTQLFRQAVTEAGLVPHDLLHDITCNFAENIVMCLERPLARACPLPVVETMTRALHEFLPPACAPIPAVWDRHWTHAGDTERGQARGDQLHGDAQGQDQGQQSHGDGQGQGQGQQLHGDGQGQQLHGDGQGQQLHGDGQGQGGTDEAGEATDFDLEGWAEEEEYLPLETIIVEGGLPDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1CBC4</accession>
    <name>A0A3S1CBC4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_004145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000093">
        <property type="protein sequence ID" value="RUS88092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS88092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="225" mass="24539" checksum="E0A6E4A6183E974A" modified="2019-04-10" version="1">MAQSALTGEQRGDGKTTARAKDLQVDTHVHGKEERVGEEEKDGGDSWTPATDRRDGIEREEGGKREGEREIEGGGGXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGADGLCFRVDAGTVGRMAQSALTGEQRGDGKTTVRAKDLQVDTHVHGKEGRVGEEGKDGGDSWTPATDRRDGIEREGGGKRERGRERDRGGRKERNKTMEDTDGHQTNLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1CEG0</accession>
    <name>A0A3S1CEG0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_001801</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000032">
        <property type="protein sequence ID" value="RUS90460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1CEG0"/>
    <dbReference type="STRING" id="188477.A0A3S1CEG0"/>
    <dbReference type="OrthoDB" id="6369184at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000058">
        <property type="entry name" value="CUB domaincontaining protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053207">
        <property type="entry name" value="Non-NMDA_GluR_Accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47537">
        <property type="entry name" value="CUBILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47537:SF2">
        <property type="entry name" value="CUBILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUB" evidence="3">
        <location>
            <begin position="20"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="3">
        <location>
            <begin position="156"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="3">
        <location>
            <begin position="296"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS90460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="478" mass="54621" checksum="2A7B6C25C30540A2" modified="2019-04-10" version="1">MSPPPGKYITTGTRLEGKHCTYEFYSNATHKTGRFFSPFYPQNYKPNGTCRYNFHALPGERVKIVFKNVQLHDTASSCRDSPDVIKVYDGLDASANVIGHLCGIHNDEEVISTGTNLYVAFTCDDKNQKQGEPPKFEFLFTMVKSTSNVSSSDQDCNQHIKSTEHRNGSISSPKYPFAYPADITCRYVFTGVGRERIQLRFLHMDLHFPRGDPTEPVDCGGSDSVTVYVIINGTTERIDTWCGKELPHMLMSSQHKMIVEFKSYHSSMEVTGFMAHYSFVTNFGILEGQQDNRGMCVFNYQSSVKSHGEITSPNYNGLYPRNTECHYLFYGKENERVRIEFVDFDIEGYMPRCDERSDYVSFSNFANSEDRKMTRLCGGPHNRVVWSDGPFFRVIFKSNECFDSTGFQAYYQFIASEQEKKDQDVQPLEEETYSVQGRRNSGIGSSVASAVNRRLESRFQSQLLSLSRSSVLWRTWEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1CEI4</accession>
    <name>A0A3S1CEI4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PLAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_001752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000031">
        <property type="protein sequence ID" value="RUS90484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6123187at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1399"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1437"/>
            <end position="1456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS90484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1469" mass="168565" checksum="64B3213897579FB7" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1CEV5</accession>
    <name>A0A3S1CEV5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_001494</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000025">
        <property type="protein sequence ID" value="RUS90783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1CEV5"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS90783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="259" mass="28833" checksum="DD977B55B7FB17E0" modified="2019-04-10" version="1">MEDFVKLFRRLETKSPRLRAIYIRGFSAHDHGHLELHIYAVQRPPYTACTRFLKMEFFPLSTHLRKQAASKQEIPSHTDFPSAKIFLLLNGNLNSVAKPALTKLNACESGLPASIYLSEPSRDVVTGYLEHLKRPLSPSPVSVTRHLFDSFISGQGPGIGPSMCYESAFNSRIALRGEGTNLAWHVLQVGALSKYQLSCSGAPLRYLELELFQFRSVQLRFISHNSGSFRLTLCLQTYCGMPDQGSNCPGGQDSLSALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H1R9</accession>
    <name>A0A3S1H1R9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_021761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001400">
        <property type="protein sequence ID" value="RUS70477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H1R9"/>
    <dbReference type="STRING" id="188477.A0A3S1H1R9"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS70477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="194" mass="22460" checksum="EEDF9FDB5A86BB7E" modified="2019-04-10" version="1" fragment="single">HSIGLSCYWTIILLGYHAVGLSGCWAIRLLDYQAIGLSFYWSIRLLDYHALGLSDYWFIMLLVYHAVGLSCYWTIMLLDCHSIGLSFYRSIRLLDYHSIGLSGYWTIILLDYQAIGLSFYSSIILLVYHAIGLSCYWNIILFVYHSIRLSGYWTTILLSIMMLGYHSIGLSFYWTIILLDYHSIGVSCCWAIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H8F5</accession>
    <name>A0A3S1H8F5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_018007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000852">
        <property type="protein sequence ID" value="RUS74239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H8F5"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS74239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="271" mass="29198" checksum="C2DBC2FFE096FF27" modified="2019-04-10" version="1" fragment="single">VVHHVVRLHVRHLGPHLGEVVDLGVLEKVLHPGVLDCAVLDLGLLRQVGHRLVTYVDRGGYFLDGEEGGQVGCVRGDKDEGEEPPGAGLFIKRHPPPTLHKRAQDEPEGLPDGHWGEVPTGLSVQTPAHPLQAIQNPGHDQEGGQDDHPHHGGERAQELEVGRLVGGHAHQHRDVSCHERLGEVHSALPVGVDGQGRHGHCGFNALAHPSNQLSNNAVPLSVGHLAAKLAVVDQIEVVVEVQLFGHILDEIYGETLKLVIARSGLVVFFEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HAY0</accession>
    <name>A0A3S1HAY0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_016606</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000723">
        <property type="protein sequence ID" value="RUS75635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S1HAY0"/>
    <dbReference type="OrthoDB" id="2441647at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026202">
        <property type="entry name" value="GOLGB1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18887">
        <property type="entry name" value="GOLGI-ASSOCIATED PROTEIN GCP360-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18887:SF5">
        <property type="entry name" value="GOLGIN SUBFAMILY B MEMBER 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="5418"/>
            <end position="5436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="518"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="651"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1251"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1839"/>
            <end position="1872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1928"/>
            <end position="1947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2412"/>
            <end position="2434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2760"/>
            <end position="2784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2817"/>
            <end position="2897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2923"/>
            <end position="2952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2999"/>
            <end position="3090"/>
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</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
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                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
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                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
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                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <sequence length="583" mass="63681" checksum="2012BB38EF5C05A9" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HZA5</accession>
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        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
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            <taxon>Gastropoda</taxon>
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            <taxon>Panpulmonata</taxon>
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            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">EC2010</strain>
            <tissue evidence="16">Whole organism of an adult</tissue>
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    </reference>
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        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="RQTK01000065">
        <property type="protein sequence ID" value="RUS89131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S1HZA5"/>
    <dbReference type="OrthoDB" id="1866797at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1390">
        <property type="entry name" value="ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056593">
        <property type="entry name" value="ANK_LRRK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056597">
        <property type="entry name" value="ARM_LRRK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056602">
        <property type="entry name" value="Beta-prop_LRRK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032171">
        <property type="entry name" value="COR-A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057263">
        <property type="entry name" value="COR-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020859">
        <property type="entry name" value="ROC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051420">
        <property type="entry name" value="Ser_Thr_Kinases_DiverseReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48005">
        <property type="entry name" value="LEUCINE RICH REPEAT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48005:SF13">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DDB_G0278509-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23745">
        <property type="entry name" value="ANK_LRRK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23744">
        <property type="entry name" value="ARM_LRRK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23748">
        <property type="entry name" value="Beta-prop_LRRK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16095">
        <property type="entry name" value="COR-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25497">
        <property type="entry name" value="COR-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08477">
        <property type="entry name" value="Roc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51424">
        <property type="entry name" value="ROC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Roc" evidence="15">
        <location>
            <begin position="1019"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="1580"/>
            <end position="1841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="540"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="583"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="595"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RUS89131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="2238" mass="251964" checksum="88033AE9118C3063" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SKV4</accession>
    <name>A0A433SKV4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_022484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001585">
        <property type="protein sequence ID" value="RUS69754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SKV4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS69754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="239" mass="25563" checksum="C8D44CE8D281B9E5" modified="2019-05-08" version="1">MALQPHSTTPHPHPPRPAYHMSRAVSDHVTDVARKHPAPPRRFSDSESCREHDGPSNEARIIAFRRAQALQEMILLGARDTGLSPTRNSDPYVGGTHCEVVPEIPATPSPPPGVSSNLARRLSDTALYSSQISDFDEMTSSTEEAGALLTPPPGFADEPDISTWDSTKMTLTITTAACATGTCTTSTCTTCSPTGTRPPVEAASPSRSPAWPTPQDQGGTRECMEPLEYLVSTTTERPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SNJ0</accession>
    <name>A0A433SNJ0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_021441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001332">
        <property type="protein sequence ID" value="RUS70793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SNJ0"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS70793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="149" mass="16657" checksum="BC427CF98933CA1A" modified="2019-05-08" version="1" fragment="single">NTWQSIVTDLQGQERNFLKFSFGISSVCTQNRHNKGLWIAMLLPAVVVAASTKCRDEIDTCMNDYSESEGCKALNRLEDCVLATSVDCIYYKEDQDLYQAVRGAVLYKLNDWSCTIVSYVSGSQRPATVSWLVGSMVGVTWICLFLCGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SR71</accession>
    <name>A0A433SR71_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_020495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001167">
        <property type="protein sequence ID" value="RUS71742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SR71"/>
    <dbReference type="OrthoDB" id="188124at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029059">
        <property type="entry name" value="AB_hydrolase_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12695">
        <property type="entry name" value="Abhydrolase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019488592" description="Alpha/beta hydrolase fold-5 domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-5" evidence="2">
        <location>
            <begin position="41"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS71742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="481" mass="53992" checksum="B57798BD201387F1" modified="2019-05-08" version="1">MSGIRTLVWVALSVLCVQTGSALVTTRILRPIRETGDEVGLIFFPESDVKGEDYNKTARAIQEASKLRVWVALTDNYLFDVVTGPDVYDAMIKAVKKLVGAGMESDSFVGVAHGWSGYLLQTYAQNSGLKAIILMGSTVARNTQLRDFPIPVLTLAAELDGVTRMTRIVEEYDKLTKGMPASFRGLYRTPVIYIEGANHAQFASGSDQSLIDKSRDLEPEITDDEAHRWIGKYVNDFLTVTFSSEEDDVDNSLTALVEPFMDAVNKFQPFLDMRNFDTNGVKSMWTVVAQKMFAGEYSDEVAVSNEVVGNPWFYVKSPSVDLNDFKVVLDTKTLVDVATKSDSWKFQSQMESPVEIDMKLVSKNAIWEKLAAHNDSSLRTEPNSCEALNQFALTLAIAMSTEKAQERYLARGWPIILEEDAMRWSNALWTPSRLRMWEDIDGLHVRSVAMETDDAHYCKVLSVYRAMEWVNIDSVRVNPFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SUM9</accession>
    <name>A0A433SUM9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mediator complex subunit 19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MED19</name>
        <name evidence="8" type="ORF">EGW08_019252</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000989">
        <property type="protein sequence ID" value="RUS72987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SUM9"/>
    <dbReference type="STRING" id="188477.A0A433SUM9"/>
    <dbReference type="OrthoDB" id="10044050at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019403">
        <property type="entry name" value="Mediator_Med19_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22536">
        <property type="entry name" value="LUNG CANCER METASTASIS-RELATED LCMR1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22536:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10278">
        <property type="entry name" value="Med19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="160"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="215"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS72987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="243" mass="27064" checksum="C6F812ACD06E487F" modified="2019-05-08" version="1">MADLIRRPEPMQSSPRSSPRDRGSRSPAYPRQDSSGTLKTTISLVPGKTPSVIHTGSFYLVKDIPDEAEITGSTNLLSYYNLEHSYNRFLNKKVKEELSAFLPHLPGNIDSPGIQDNSSLRSLIEKIPIMNKDMNQLSGSALSGFRLHPGALPEQYQTMNQMTQKKKKHKRKSKESEKGSALQLAQDISTADNPSAEPEARKNKRPKREDEPKDSKKKKKKEKKKKKKHSPDTAGTNGAEAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SVQ6</accession>
    <name>A0A433SVQ6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_018908</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000948">
        <property type="protein sequence ID" value="RUS73336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A433SVQ6"/>
    <dbReference type="OrthoDB" id="6163019at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="317"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="657"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="714"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="816"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="915"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="967"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1272"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1597"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1920"/>
            <end position="1950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2017"/>
            <end position="2042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2073"/>
            <end position="2099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2111"/>
            <end position="2218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2705"/>
            <end position="2730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3423"/>
            <end position="3444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3513"/>
            <end position="3539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3606"/>
            <end position="3668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3875"/>
            <end position="3899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3947"/>
            <end position="3978"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="335"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="385"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="659"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="714"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="733"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="753"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="816"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="915"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="927"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="971"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1274"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1317"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1605"/>
            <end position="1640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1920"/>
            <end position="1930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1932"/>
            <end position="1950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2017"/>
            <end position="2027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2111"/>
            <end position="2159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2185"/>
            <end position="2205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="3424"/>
            <end position="3441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="3522"/>
            <end position="3534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="3617"/>
            <end position="3641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="3650"/>
            <end position="3668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="3881"/>
            <end position="3890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="3962"/>
            <end position="3978"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS73336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="4081" mass="436002" checksum="293AAF2D05B4788A" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SW28</accession>
    <name>A0A433SW28_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_018728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000928">
        <property type="protein sequence ID" value="RUS73513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SW28"/>
    <dbReference type="STRING" id="188477.A0A433SW28"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="1">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS73513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="376" mass="40949" checksum="B1AD32BE13E1A46E" modified="2019-05-08" version="1" fragment="single">ENVNCAIATCIPSTPAGTRYPSGRCCNKYFECNGGALTEMSCPNGLVFSIAERACIQVIDTKAVCDMQERYVCDVNTGGVGTNTTGCGAYSPDPFGNPCRFLFGGYTINAPQGTMWSQTACSLVFANTDQCGQLQSGSSAFFGAQPADFCNAVFLATFDNGQRTVYSERQQQNLAVAVSTQEARLQQNGLVFDSTMQRPYGYYFFFNNRAIKENTAFRVRFALDQNAPSNRRIDILSNNFCELCPETVSITVTPRGPNQREVTATFLLTNGQSVTTSALINNEVASNELEVTLVFGQTSIYGQVSELSGNNPNSVIQTVNFTPVQKPSGVEVQPNRCGFMLGQGPNSNFLGLIDDFAVFEYCQDINQVLRQQQTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SXZ7</accession>
    <name>A0A433SXZ7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-type E3 ubiquitin transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_018087</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000861">
        <property type="protein sequence ID" value="RUS74148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SXZ7"/>
    <dbReference type="STRING" id="188477.A0A433SXZ7"/>
    <dbReference type="OrthoDB" id="438726at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16637">
        <property type="entry name" value="mRING-HC-C3HC3D_LNX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06677">
        <property type="entry name" value="PDZ1_LNX1_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06679">
        <property type="entry name" value="PDZ3_LNX1_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06680">
        <property type="entry name" value="PDZ4_LNX1_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051342">
        <property type="entry name" value="PDZ_scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964:SF84">
        <property type="entry name" value="LIGAND OF NUMB PROTEIN X 2-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964">
        <property type="entry name" value="MULTIPLE PDZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50145">
        <property type="entry name" value="ZF_TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="40"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF-type" evidence="7">
        <location>
            <begin position="102"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="186"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="274"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="410"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="526"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="4">
        <location>
            <begin position="102"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS74148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="616" mass="67260" checksum="9A3C3A1143A03CA4" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SZ50</accession>
    <name>A0A433SZ50_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_017665</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000818">
        <property type="protein sequence ID" value="RUS74584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SZ50"/>
    <dbReference type="STRING" id="188477.A0A433SZ50"/>
    <dbReference type="OrthoDB" id="6141094at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001443">
        <property type="entry name" value="Zinc finger protein 668"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS74584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="434" mass="48409" checksum="2B10A47164CFD3FA" modified="2019-05-08" version="1" fragment="single">CTLCLAQFSSNRELIQHHKDVHPGEMPWECDVCSKRYHKKVAMKAHMRVHNAMARYQCSTCKKLVFYDSLTLFHRRIHTGEKPNVCPICGQRFRQGSTMQAHMKRHTHDKPFICRYCRMRFAYQDEVTEHELAHAHNKKWQCDECGMRFKNQSLLARHCRRHTNERPFVCEICSKSFVQSGSLRAHMRSHTNEKPYYCRMCSKAYATSGTLLLHIRKVHNLAAKTVKEVFPVNKYIEDQKVFTIRNKTLLGNEMVVHSDGMTAGGERFTVVVDESSNANTSSAQQISGDKPSTDSMSSNLEDAIHGDTEPPPNVIVVTSEGEFSVTPSTQVDVVVGSDNAHVETVAQAFSKPARDAETEVLTKLEPLGDIWNTQEDDSEPVQVAAEVDISSHSLHSAQDRQEAALGLAELSLFGAGAAGANANSGESTSTSASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SZF2</accession>
    <name>A0A433SZF2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibrinogen C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_017556</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000809">
        <property type="protein sequence ID" value="RUS74676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SZF2"/>
    <dbReference type="STRING" id="188477.A0A433SZF2"/>
    <dbReference type="OrthoDB" id="6272435at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF444">
        <property type="entry name" value="PROTEIN SCABROUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="2">
        <location>
            <begin position="20"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS74676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="247" mass="28783" checksum="AD750B559F38E207" modified="2019-05-08" version="1">MLEKRDVDEQLILKQTESALKKFFMSETCQKNETIFRFPMLPHPVFYITFGQSIIPVLCDMVTDGGGWIVIQRRTKGDVDFYRDWASYKTGFGTLDTDFWLGNDNIHYITSTGKYELRVDLKYGSDWLYYELYQNLYIASEKDNYRLHFESYSGNAGDSLSSHNGWPFSTYDVDNDDALMNCAEKHHGAWWYHLCYHSNLNGKWGAGDYKGLVWNTLTRSASATFSEMKIRKSGNLTPMESEERFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T2I1</accession>
    <name>A0A433T2I1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tetrapyrrole biosynthesis uroporphyrinogen III synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_016464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000712">
        <property type="protein sequence ID" value="RUS75778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T2I1"/>
    <dbReference type="STRING" id="188477.A0A433T2I1"/>
    <dbReference type="OrthoDB" id="5595751at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390">
        <property type="entry name" value="UROPORPHYRINOGEN III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390:SF0">
        <property type="entry name" value="UROPORPHYRINOGEN-III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="HemD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrapyrrole biosynthesis uroporphyrinogen III synthase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS75778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="110" mass="12228" checksum="052B4873FAE8B250" modified="2019-05-08" version="1" fragment="single">MDGQSEHELKASSKETVFLFKSPKESEHDKFTEVLKHAGFACANIPVLSFQFVNQEDLKSNLSAIHLFSAIIFTSVRAVEAVKNVIQDIEDNLSIYNLQSFAVGHTTVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T2W7</accession>
    <name>A0A433T2W7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_016351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000703">
        <property type="protein sequence ID" value="RUS75892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T2W7"/>
    <dbReference type="OrthoDB" id="8185397at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="141"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="295"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="380"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS75892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="543" mass="62326" checksum="140C11258FF9D11E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T2X4</accession>
    <name>A0A433T2X4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_016353</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000703">
        <property type="protein sequence ID" value="RUS75894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T2X4"/>
    <dbReference type="STRING" id="188477.A0A433T2X4"/>
    <dbReference type="OrthoDB" id="5954035at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097524">
        <property type="term" value="C:sperm plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008126">
        <property type="term" value="F:acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051792">
        <property type="term" value="P:medium-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048240">
        <property type="term" value="P:sperm capacitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043401">
        <property type="term" value="P:steroid hormone receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF45">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE ABHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="48"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS75894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="158" mass="17303" checksum="8EC339B5E8A051B0" modified="2019-05-08" version="1" fragment="single">MVYARMGRLNVRVPDGVRHSKIMPDGANLTFDLYEPFRPHPTGESHCIIFCPGIGNNSESPYIQSLVHHSQQLGYISVVLNHLGSLKKLPLTSPRIFTYGGTEELGAVRSEVERIHPGCHLILVGCSMGANIVVKYLGEDPAHQRGILAAVSVNQGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T3N6</accession>
    <name>A0A433T3N6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-Fucosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_016080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
            <location evidence="3">Golgi stack membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="3"/>
    <dbReference type="EMBL" id="RQTK01000683">
        <property type="protein sequence ID" value="RUS76168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T3N6"/>
    <dbReference type="STRING" id="188477.A0A433T3N6"/>
    <dbReference type="OrthoDB" id="6041477at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008107">
        <property type="term" value="F:galactoside 2-alpha-L-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002516">
        <property type="entry name" value="Glyco_trans_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11927">
        <property type="entry name" value="GALACTOSIDE 2-L-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11927:SF9">
        <property type="entry name" value="L-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01531">
        <property type="entry name" value="Glyco_transf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1 3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS76168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="243" mass="27925" checksum="E0A83B3EE74D938D" modified="2019-05-08" version="1">MHGVITFDRSRCEQAADASNFKRGIYDEGFLKRITGKEDIKLRGFFQSYKYFERWEREVRDVLAFREDVLTKAMEAINILHFRKLGTSLYHSDTAEALDLVGVHVRRYPADRRRREGLGYRTAPEDYVSFAMSEMKAWILNRDSPPDVRFFVVTDDPAWAESKLGLKALPDTMLVKGLDWAANLALLASMDDVIVTVGALGWWGAWLADGRSMYYQDFVKPGSEMDSAYLANDFFPPYWLGMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2024-01-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T3T5</accession>
    <name>A0A433T3T5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M12B propeptide domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_016058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000682">
        <property type="protein sequence ID" value="RUS76180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T3T5"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002870">
        <property type="entry name" value="Peptidase_M12B_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01562">
        <property type="entry name" value="Pep_M12B_propep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M12B propeptide" evidence="2">
        <location>
            <begin position="68"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS76180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="145" mass="16097" checksum="F0B8B4263145A73F" modified="2019-05-08" version="1" fragment="single">MELLLTPHFSAYKTKPWILLDYKFVVVLLCYTVIHSVIYLPGANGYTPGANGYSPSARSFFHRYHDSPVRLSSGGHVITSTLDGQGSHYNTVTAEFTAFGKHFVLDLSLNRQLISGAFVQKVFHGTNQHSSSGVEDVFHSRVPHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T4W7</accession>
    <name>A0A433T4W7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_015615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000648">
        <property type="protein sequence ID" value="RUS76639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T4W7"/>
    <dbReference type="OrthoDB" id="10289242at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS76639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="723" mass="79071" checksum="E839E63903C5E25E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T5W3</accession>
    <name>A0A433T5W3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_015307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000623">
        <property type="protein sequence ID" value="RUS76934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T5W3"/>
    <dbReference type="STRING" id="188477.A0A433T5W3"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="1">
        <location>
            <begin position="52"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="1">
        <location>
            <begin position="561"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS76934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="822" mass="87737" checksum="9C543FA772E89A66" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T5Y8</accession>
    <name>A0A433T5Y8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_015363</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000627">
        <property type="protein sequence ID" value="RUS76872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T5Y8"/>
    <dbReference type="STRING" id="188477.A0A433T5Y8"/>
    <dbReference type="OrthoDB" id="8964674at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS76872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="145" mass="16353" checksum="07C4C8D462DA80FF" modified="2019-05-08" version="1" fragment="single">ICTRILVGCESEICILVGWESEICILVGWESEMHILVGWESEICILVGWESEICILVGWESEICVLVGWESEICILVGWESEICVLVGWESEICVLVGWKSEICILVGWESKICILVGWESKICILVGWESEICILVGWESEICI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T8E1</accession>
    <name>A0A433T8E1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Citrate transporter-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_014364</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000546">
        <property type="protein sequence ID" value="RUS77851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T8E1"/>
    <dbReference type="STRING" id="188477.A0A433T8E1"/>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015141">
        <property type="term" value="F:succinate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031312">
        <property type="entry name" value="Na/sul_symport_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001898">
        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF82">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00939">
        <property type="entry name" value="Na_sulph_symp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01271">
        <property type="entry name" value="NA_SULFATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="490"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS77851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="541" mass="59490" checksum="AE4FFC497FD105D3" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T9W6</accession>
    <name>A0A433T9W6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_013993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000523">
        <property type="protein sequence ID" value="RUS78254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T9W6"/>
    <dbReference type="STRING" id="188477.A0A433T9W6"/>
    <dbReference type="OrthoDB" id="20943at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS78254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="189" mass="21075" checksum="E05EBC1B8B9261B0" modified="2019-05-08" version="1" fragment="single">MDSAASDEIVTKVEAVSPQVIHENGTAMEDIPEPTLSLEHQSNDTAVDNEQTPDVIDEQEQKPEVENEITPKPEQTTPAISQLDTKTQVRAPLLELPDMMGDGQSQPKRLKFENGSDTESQEPYFPQSEQYGPVLDGPGAKRDVKPFKPPKLGVQQQEDVQRAKKFAMEQSIKSVLVRQTIAHQQQVYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T9Z0</accession>
    <name>A0A433T9Z0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_013849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000512">
        <property type="protein sequence ID" value="RUS78401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T9Z0"/>
    <dbReference type="OrthoDB" id="6777847at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS78401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="150" mass="17947" checksum="D418BCA2D5D4E5EC" modified="2019-05-08" version="1">MDKKGSLKHTQQEREEQRVRTLEQRVRTLEQRVRTLEQRVRTLEQRVCTLEQRVRTLEQRVCTLEQRVRTLEQRVYTLEQRVCTMKQRVCTLEQRVRTLEQRVYTLEQRVHALEQKGAHSLFQGAHSLFQGANSLFQGANYLFHGAHSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TBV3</accession>
    <name>A0A433TBV3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_013359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000484">
        <property type="protein sequence ID" value="RUS78884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TBV3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS78884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="126" mass="14084" checksum="D64AFDB55996C5E4" modified="2019-05-08" version="1" fragment="single">KGLWSHSQALKQPVTSDPQPLRRDPGPDLHPARGPSPKVKGKKPKSVMEDIPQEGEPIESDVQLITNGHLLPLDPSVTAPVSSGDDPKVKAKRLWTDIYTKRETMYWKNLKPFVFVKTLPKRCQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TC25</accession>
    <name>A0A433TC25_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc/iron permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_013084</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000468">
        <property type="protein sequence ID" value="RUS79137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TC25"/>
    <dbReference type="STRING" id="188477.A0A433TC25"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF203">
        <property type="entry name" value="FI18611P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS79137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="29499" checksum="19966CE22AE12713" modified="2019-05-08" version="1">MDVTLCKVITAILLFILTLVFSSIPYFIVARGTRSGRSAQRREWILGHLNCFAGGVFLATLLCHILVEGEEGFEDYKEKARLHTDFPLFNIFVAAGFFIVAFVEFVAHSIMAKKNVADIMHEGTQNERDEATPQFARFDGEGEAQETQITHAHIPNTDGLRPFLLLIALSFHTIFDGLAVGLQTSESEVWVVFAAITIHKSVIAFCIGLEIFQGNRDKLVQAAMWLLIFAIMSPIGIGVGIGITSGSSDELARLLAASILQGLAGGVGTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TDA0</accession>
    <name>A0A433TDA0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_012666</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
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    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <source>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RUS79572.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="642" mass="70579" checksum="666E5A6EE9F4CE7B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A433TIC1_ELYCH</name>
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        </submittedName>
    </protein>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
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                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="EMBL" id="RUS81314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
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</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000316">
        <property type="protein sequence ID" value="RUS81887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
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        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
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        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="21"/>
        </location>
    </feature>
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        </location>
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        </location>
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        <source>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS81887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="713" mass="79938" checksum="17EB2534B7F4F092" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TQR0</accession>
    <name>A0A433TQR0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_008269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
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        <lineage>
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            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000271974">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="786"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        </location>
    </feature>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS83963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="883" mass="93378" checksum="5A23F8F0BA66E572" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TV74</accession>
    <name>A0A433TV74_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase M12B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_006830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000170">
        <property type="protein sequence ID" value="RUS85439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TV74"/>
    <dbReference type="OrthoDB" id="6150789at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13688">
        <property type="entry name" value="Reprolysin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS85439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="36833" checksum="BAF1E3A0EE0DB9F6" modified="2019-05-08" version="1">MPDHLRFEVPVARQPVTLNMKRTKLLPTATSTSDLTQPFLKDAAVYTDVNHLGSMIVRRNRGRQYSLQGSFVHDQAEWHLEPLSRVRRQADGNVSHRLLAEPPDEETISYVGDAIEDEEPEYSHKEIIFYAWDAINDDEPAVEILSLEARNYYRLLKLNKHKAGGTNVTHGSIPDEPEDLQKNGTVNRASVEHVVEMVFVADYADYQKSISDPNLSIGTRVTFLKILTRDSDDDFIEDLTSSGVFDGPAALSAFRTWYQEPANGIPNADHYMLFTGFDMQNYIGIAYLSRLCTASGVSITENRFNAWVAKTAAHEVGHRASKNDMVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TYL2</accession>
    <name>A0A433TYL2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Charged multivesicular body protein 4b</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_005589</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000132">
        <property type="protein sequence ID" value="RUS86640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TYL2"/>
    <dbReference type="STRING" id="188477.A0A433TYL2"/>
    <dbReference type="OrthoDB" id="5592979at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF10">
        <property type="entry name" value="GH13992P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS86640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="25118" checksum="F90FB44E683504E0" modified="2019-05-08" version="1">MSLLKRLFRIGEGGKTPTAQEGIQRLRDVEEMLNKKSEFLEKKIEAQIRIAKENGTRNKRVALRALKTKRNFEKQLQQIDGSLSTIEYQREALESASANVEVFNVIRVASDALQGLQGQLDIDEVHKIMDEAAEQKELADDLSDLISNPENFGGQVFDEDDLLAELEELEQEELNEKLLDVGETAYNLPSIPTSEPAASVKNSKVRRKDDDEAVMDELAMWAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TZW3</accession>
    <name>A0A433TZW3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_005117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000119">
        <property type="protein sequence ID" value="RUS87117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TZW3"/>
    <dbReference type="STRING" id="188477.A0A433TZW3"/>
    <dbReference type="OrthoDB" id="10357384at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045095">
        <property type="term" value="C:keratin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009970">
        <property type="entry name" value="HC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07382">
        <property type="entry name" value="HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS87117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="283" mass="36565" checksum="416D4751F91BA65A" modified="2019-05-08" version="1" fragment="single">YRKVRYRKTCYCKTCYRRTCYRNTCYRKTFYRRTCYRKTFYRRTCYRKTFYHMTCYRKTCYRKTCYRTTFYHMTCYRKTCYRKTCYRKTCYRKTCYRKVCYRKVCYRKTCYRRTCYRNTCYRKTFYRRTCYSETCNRETCSRKTCYRKACYHKTCYRKTCYRKTFYRKTCYHKTCYCKTCFSYLSVFLPLSHSHSLSTCYRKTCYRKTCYRKTCYRKTCYRKTCYRRTCYRKTRYRKTSYRNTFYRKVHYRKVCYLKTCYRKVCYRKTCNRKTCYRKTCYRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U016</accession>
    <name>A0A433U016_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">6-phosphogluconolactonase</fullName>
            <shortName evidence="6">6PGL</shortName>
            <ecNumber evidence="4 6">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_005034</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="4 6"/>
    <dbReference type="EMBL" id="RQTK01000117">
        <property type="protein sequence ID" value="RUS87194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U016"/>
    <dbReference type="STRING" id="188477.A0A433U016"/>
    <dbReference type="OrthoDB" id="432544at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000005">
        <property type="entry name" value="6-phosphogluconolactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="6PGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054:SF0">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="7">
        <location>
            <begin position="11"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS87194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="242" mass="26134" checksum="A509490692129DAB" modified="2019-05-08" version="1">MAAPTIKVVPSEVEVSNELCELVITSANASIKERGIFTFGVSGGSAAKFLCNGLPQASTDWSKWRVFFCDERLVPFSDPECTYAYYKTNLMSKVPIAEEHFFALNPDLSVEDAAVDYEKKLRTVFPSGVPRFDVLSLGMGPDGHTCSLFPGHPLLKETEKLCAPISDSPKPPPQRVTLTFPVINNAACCVFASCGAGKADIVQQVLEDESDEPLPAARVRPANGDVVWILDKPAAGKLQASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U075</accession>
    <name>A0A433U075_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_004993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000116">
        <property type="protein sequence ID" value="RUS87241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U075"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS87241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="110" mass="12575" checksum="B410F99B20CF5A65" modified="2019-05-08" version="1" fragment="single">MNKSRVHVAYRQCGRDVLVFAMPGNRITPSCLEMVLDAFTSLLVLLFGDVQSAFQDCDRVWLDKIMALTFQRALALPSVHQKPDLFQWPSLLSMLTSDMWHVRSLGLSYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U199</accession>
    <name>A0A433U199_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphatidylinositol-specific phospholipase C X domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_004654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000106">
        <property type="protein sequence ID" value="RUS87609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U199"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08557">
        <property type="entry name" value="PI-PLCc_bacteria_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF140">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26146">
        <property type="entry name" value="PI-PLC_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS87609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="38768" checksum="FA2730DD43F19CFF" modified="2019-05-08" version="1" fragment="single">SFTLDGGWVDTRLPCDLNAAAQWDLNQAIFIKGTWFWTFDGEIKGPFHTDTLHLCSWYLCGEADWMVDPNPEPLDCNGDRRLCHLRLNQVTMPGLHNAGSGFHGGFSFADCLVRNHARSILQQLRLGIRYLDIDSSYSTCGVLGTNHKVFCGGSVCRLLKEVRMFLSEAPHEVVTLTFNHDMQDAEVVIPALTRQLQSQLGPMLNDDFRASGEERWPKLHTAVRTNKRVFVFYTPAVHDTASARRLYTLNRWIHTERWVASTWTPTANHDGNCSKLVDLTVDRCRELQGRQLLEMSLILWDLTLCIRDLADRCRGRGILRSALRGCEPYRYSHNSSPNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U2H7</accession>
    <name>A0A433U2H7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_004189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000094">
        <property type="protein sequence ID" value="RUS88023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U2H7"/>
    <dbReference type="OrthoDB" id="6118545at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46563:SF4">
        <property type="entry name" value="ASPARTYL_ASPARAGINYL BETA-HYDROXYLASE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46563">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="439"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="501"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS88023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="632" mass="66022" checksum="F60467FBE0687907" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U655</accession>
    <name>A0A433U655_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_002918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000059">
        <property type="protein sequence ID" value="RUS89311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U655"/>
    <dbReference type="STRING" id="188477.A0A433U655"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS89311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="252" mass="28206" checksum="73AB176BC3DD53DF" modified="2019-05-08" version="1">MVMMQGEKVEMMVILQGEKVEMVILQGEKVEMVVMIREENVVEMMGIMQSARREGGDGGDDARREGGDDGDNARRENGDDARREDGDDARREDGDDARREGGDGGDDARREDGDDGDDVRREVGDGGDDARREDGDDGDDVRREDGDDARREVGDGGDDVRRECGDDGDDTRREDGDEYFGDLEFLVEHPVTEDVEKEIGLKQMMTELKCQTRKVEISVRVSRIKVVQSCRWLVKCAIIGGTSLFEIRTHLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z3Y5</accession>
    <name>A0A3S0Z3Y5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">EGW08_023406</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">EC2010</strain>
            <tissue evidence="18">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001980">
        <property type="protein sequence ID" value="RUS68832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z3Y5"/>
    <dbReference type="STRING" id="188477.A0A3S0Z3Y5"/>
    <dbReference type="OrthoDB" id="9439254at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19193">
        <property type="entry name" value="PR-SET_PRDM7_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000882">
        <property type="entry name" value="Predicted gene, 21060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003287">
        <property type="entry name" value="Zgc:113343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000478">
        <property type="entry name" value="Zinc finger protein 133"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000016">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000070">
        <property type="entry name" value="zinc finger protein 689 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000933">
        <property type="entry name" value="zinc finger protein 771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000634">
        <property type="entry name" value="Zinc finger X-chromosomal protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044417">
        <property type="entry name" value="PRDM7_9_PR-SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21549">
        <property type="entry name" value="PRDM2_PR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="17">
        <location>
            <begin position="222"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="499"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="527"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="555"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="583"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="611"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="639"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="667"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="695"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="723"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="751"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="81"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RUS68832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="778" mass="89897" checksum="C1609C96A69167BF" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z9K8</accession>
    <name>A0A3S0Z9K8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ELYS beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_019636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001044">
        <property type="protein sequence ID" value="RUS72601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z9K8"/>
    <dbReference type="STRING" id="188477.A0A3S0Z9K8"/>
    <dbReference type="OrthoDB" id="20729at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032040">
        <property type="entry name" value="ELYS-bb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052620">
        <property type="entry name" value="ELYS/MEL-28_NucAsmblyFactor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21583">
        <property type="entry name" value="ELYS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21583:SF8">
        <property type="entry name" value="PROTEIN ELYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16687">
        <property type="entry name" value="ELYS-bb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELYS beta-propeller" evidence="1">
        <location>
            <begin position="1"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS72601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="466" mass="52946" checksum="61B2EC0EBCC23DAF" modified="2019-04-10" version="1" fragment="single">VVHVVEIPNRISALEVVFENETEEVSPWIISKHLQFFSGLLAVGTEGGFVYLVDLCLDDLDMSFASEAAPKKLMIITPRIVDPLHKKEQARSYDKHLALLLDDQCHKQEQFYYRRQDDTIQKVFEEGAVWVSSLTYMAQAGTLAIGFSFGCFQLWRLYNPVLDYSSRYNPDNQAVTHFLSQEPENDPRNFVYLWVVYDNASDDSISSICLYQLSFTKKDAYANFGIFYDELESVCPRLDHKLTGDPYSVQHGATIRSAVVNCYTLQNPLYTPPSILSESFEDGFHGNDSSLSVFVWRADSSQAGRGSATSSYWLSVFDMNRWYHAQMPHAMRCHGASLQVCSFWAVYDLDNVVSCLPSQALLNVEVNGKRVLRFVNNTPVPPEEHSYPSALQLSDVCFVAPDGAVQAQCYGWQKSLLREMVVSGAEHLVQPADFYHQCLRARLLPQSFEESKTRSTAYQRKMLLNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z9N4</accession>
    <name>A0A3S0Z9N4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_018341</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family. PAR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000889">
        <property type="protein sequence ID" value="RUS73890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z9N4"/>
    <dbReference type="STRING" id="188477.A0A3S0Z9N4"/>
    <dbReference type="OrthoDB" id="6022300at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14695">
        <property type="entry name" value="bZIP_HLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000007">
        <property type="entry name" value="hepatic leukemia factor isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040223">
        <property type="entry name" value="PAR_bZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11988">
        <property type="entry name" value="THYROTROPH EMBRYONIC FACTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11988:SF56">
        <property type="entry name" value="TRANSCRIPTION FACTOR CES-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="151"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="63"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="144"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS73890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="214" mass="23700" checksum="3B41A20A1A420EDC" modified="2019-04-10" version="1" fragment="single">KSTRPFKAYPKEALQMPLGGFFGAPGLSSSLLQQGIDSGMFAGMNTEDLMSLYNQQLQVLREKQVSSSTPTSIQGHKGNASPPVSPTLTNGSGNNHHESHLNHQQHSKFRNHQQGPSTLVSSTSPSPSSSSHHGSSNSRKRPRSLPDEQKDAAYWERRRKNNDAAKRSRDARRAKEDEIALRAALLEQENIKLRVEVASLKTETSRLRCLLYNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZAA0</accession>
    <name>A0A3S0ZAA0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_021931</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001442">
        <property type="protein sequence ID" value="RUS70308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZAA0"/>
    <dbReference type="STRING" id="188477.A0A3S0ZAA0"/>
    <dbReference type="OrthoDB" id="6591996at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000253">
        <property type="entry name" value="Crooked legs, isoform H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001397">
        <property type="entry name" value="Datilografo, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001666">
        <property type="entry name" value="MDS1 and EVI1 complex locus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001685">
        <property type="entry name" value="Zinc finger and BTB domain-containing 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000512">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000597">
        <property type="entry name" value="zinc finger protein 236 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000690">
        <property type="entry name" value="Zinc finger protein 354C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000202">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381:SF393">
        <property type="entry name" value="CHROMATIN-LINKED ADAPTOR FOR MSL PROTEINS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="236"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="236"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS70308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="293" mass="33720" checksum="45A04D8CA47E01CC" modified="2019-04-10" version="1">MCDRPYKCDLCGERFTRSNHLRDHKRTHLGTKPYGCDVCGESFAKSGNLIEHKRKHSGEKPYKCDFCDKSFARGSVLYRHLATHSQDRRFACDLCGKTFARKENLHKHSMVHSGEKPFQCDVCGKDFTRRESLTNHLAIHTGEKRYCCEVCDKRFGNRLYLHSHKKIHSEDRPYVCQECGDTFKRRGDLTSHRATHSLEKPFVCDLCNKSFTKSSNLQRHKRLHLGKVRCLLEEEHNRSNPADEKVGEDGESDIEVDPEDAKCDGGDENNANVDLLDSDTKKIASTQTDYEFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZD88</accession>
    <name>A0A3S0ZD88_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Single domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_016011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000679">
        <property type="protein sequence ID" value="RUS76238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZD88"/>
    <dbReference type="OrthoDB" id="6136898at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS76238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="21689" checksum="7DA7070685D5FBD6" modified="2019-04-10" version="1">MRSHSSSRHRRGTARAGATAADCLRSFGGFSVLCGAAALVTMMVVMSSAPSAQVRAAPLLFVEEPMIVSKELITGACVDNTGVERADLAEWTSSAGACDKVVCHVEPSGNYTVTHDCRPREPYENPDSVNCEWISNSSATYPDCCPELSCSTATPLSTIDPLLCYDLASTFACGFWYNITGGCNDTSAFMYNVSQVYCRDTCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZE54</accession>
    <name>A0A3S0ZE54_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_016692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000731">
        <property type="protein sequence ID" value="RUS75542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZE54"/>
    <dbReference type="OrthoDB" id="5586934at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33802">
        <property type="entry name" value="SI:CH211-161H7.5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33802:SF1">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS75542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="289" mass="31263" checksum="8E80140812EA0CF4" modified="2019-04-10" version="1" fragment="single">MLYPVLAVVNLLVMVGSFAINGLSGSGPDGTIFKNKTAVLSRHFYTAITPAGWTFSIWGIIYTWQALWVVYSVINIFRKTPDGDPVYSSPEFLPPALFVLSALTSCLGVAWLITFDRLEVEAAFVMLVLYSCGMYAALAVSYRALDRASPYLAQQGRTTDIWLTRGLVQNGLAIQGTWVSVATLLNLAMVLTYSGSGVASVDTAATVSLSVLALEIVVFAGTDLLLLDRWARYTLTPYGVLVLALCGSISKNYESGARNSVFSIVLLAVASLLAVVKIILTIYRHSRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZIH2</accession>
    <name>A0A3S0ZIH2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_013675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000502">
        <property type="protein sequence ID" value="RUS78568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZIH2"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS78568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="240" mass="24103" checksum="592D8E65D1D7C595" modified="2019-04-10" version="1">MPWLDFIVTVLCSEPGMGSQGPLEVSGSSVKMVDVRAGPNVTTSSLLGSNLIKLGNAVVLSAESPVPNVTTSSLLGSSSIKLGNAVVLSAESPVPNVTTSSLLGSSSIKLGSAVVLSAESPVPNVTTSSLLGSSSIKLGNAVVLSPETRSVGKDGDGGLRSAKNVTRLSIVELRGPLVVCGTFVSTEGRVASSTFSISKTGPSKESVVLDSDALEDSTGGTVVSRIFKSAVAIVSKSSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZJI1</accession>
    <name>A0A3S0ZJI1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calx-beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_011871</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000395">
        <property type="protein sequence ID" value="RUS80374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZJI1"/>
    <dbReference type="STRING" id="188477.A0A3S0ZJI1"/>
    <dbReference type="OrthoDB" id="2324346at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010855">
        <property type="term" value="F:adenylate cyclase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2030">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026919">
        <property type="entry name" value="ADGRV1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003644">
        <property type="entry name" value="Calx_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46682">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR V1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46682:SF1">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR V1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03160">
        <property type="entry name" value="Calx-beta"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00237">
        <property type="entry name" value="Calx_beta"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141072">
        <property type="entry name" value="CalX-like"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Calx-beta" evidence="4">
        <location>
            <begin position="289"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="4">
        <location>
            <begin position="414"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="4">
        <location>
            <begin position="691"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS80374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1123" mass="121700" checksum="2497027541FAF3A3" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZL51</accession>
    <name>A0A3S0ZL51_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleolar GTP-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_011935</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
            <location evidence="1 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000400">
        <property type="protein sequence ID" value="RUS80297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZL51"/>
    <dbReference type="STRING" id="188477.A0A3S0ZL51"/>
    <dbReference type="OrthoDB" id="415015at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01897">
        <property type="entry name" value="NOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000496">
        <property type="entry name" value="Nucleolar GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024926">
        <property type="entry name" value="NOG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041623">
        <property type="entry name" value="NOG1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010674">
        <property type="entry name" value="NOG1_Rossman_fold_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012973">
        <property type="entry name" value="NOG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45759">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06858">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17835">
        <property type="entry name" value="NOG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08155">
        <property type="entry name" value="NOGCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038919">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="OBG-type G" evidence="8">
        <location>
            <begin position="168"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="454"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="498"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="559"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="571"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="584"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="594"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR038919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS80297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="632" mass="72918" checksum="FBE1D1A4F793FAC5" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZNC0</accession>
    <name>A0A3S0ZNC0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_010413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000319">
        <property type="protein sequence ID" value="RUS81821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZNC0"/>
    <dbReference type="STRING" id="188477.A0A3S0ZNC0"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22106">
        <property type="entry name" value="F-box_FBXO36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="102"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS81821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="204" mass="23750" checksum="00165BD0992E62DD" modified="2019-04-10" version="1">MATVWYKRCAPWLAEDGSLYQRTDTAPSPSKDFVQVFVTPTEIVFRLWKIVPPTRADASQLPAESRATYAEFLEDAKMRGDIERTLGDRELAYLDNLLQGHIDYLNRLSRKVLLNIMYMLDLVTISKLSQVNKYLRELCSSDALWSKLYMQNTTQPITHELLMLTDKKGWKEVFFMNKVQLQMLLRRETDNPKSKDKSTVFLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZPJ2</accession>
    <name>A0A3S0ZPJ2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Nicotinamide-nucleotide adenylyltransferase 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Nicotinate-nucleotide adenylyltransferase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EGW08_020008</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">EC2010</strain>
            <tissue evidence="17">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury. May be involved in the maintenance of axonal integrity. Also functions as a stress-response chaperone protein that prevents toxic aggregation of proteins; this function may be independent of its NAD(+) synthesis activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001094">
        <property type="protein sequence ID" value="RUS72235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZPJ2"/>
    <dbReference type="STRING" id="188477.A0A3S0ZPJ2"/>
    <dbReference type="OrthoDB" id="422187at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000221">
        <property type="entry name" value="Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051182">
        <property type="entry name" value="Euk_NMN_adenylyltrnsfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039:SF0">
        <property type="entry name" value="NICOTINAMIDE-NUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018571288" description="Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3" evidence="16">
        <location>
            <begin position="19"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="226"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00075132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00079369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00093425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RUS72235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="264" mass="29280" checksum="B1AE136DFD2438E7" modified="2019-04-10" version="1" fragment="single">INCIFFFVSLLVADLTENQLPSLEDHSENLVPNVKLLCGADLLESFAVPGLWSDEDIEYIVGSHGLVVITRSGSDPQKFIYESDILTKYQENILIVTEWIFNDISSTKVRRALRRGDSVKYLLQDSVIDYIKKHQLYGIPDNKHFNKMMPSPSQDTITANHLEKDVSFKGGGTLISEVAALEDIATNPVSGEISVILRSAHNNNSKGDSSFASRHLPLHRMITHLDKKGSQAVSPHSSPLKLERKGTPTPPVKVTTTFTKDEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZQD7</accession>
    <name>A0A3S0ZQD7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_011887</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000397">
        <property type="protein sequence ID" value="RUS80348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZQD7"/>
    <dbReference type="STRING" id="188477.A0A3S0ZQD7"/>
    <dbReference type="OrthoDB" id="295078at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000001">
        <property type="entry name" value="TBC1 domain family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF16">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS80348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="132" mass="15434" checksum="109326B3E7BDFFE9" modified="2019-04-10" version="1" fragment="single">FPSHPYFSKSLGAGQLELFNLLKAYSLLDTEVGYCQGLSFIVGMLLMHMEEISAFHVLKYMMYDLGLRRQFKPNMTALQMKLYQLTRLIHDHCREVYDHFEKHDISPTLYAAPWFLTLFASQFPLGFVARVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZY80</accession>
    <name>A0A3S0ZY80_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_014145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000533">
        <property type="protein sequence ID" value="RUS78101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZY80"/>
    <dbReference type="OrthoDB" id="7487745at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS78101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="125" mass="13922" checksum="57624DB99965E084" modified="2019-04-10" version="1" fragment="single">MVSERLYDSPWLKPRGLQRQMETPGFKWSQTSLKTIGDSGFKKLPRAHLSMDHLSTKSNASMDSTRTRGQMASQSPSVASMETGMLRLYPNMAAHESRSQHTLTSPHDVLTEDRESLSSFGHGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZYM5</accession>
    <name>A0A3S0ZYM5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peroxisomal membrane protein 11C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_013826</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000511">
        <property type="protein sequence ID" value="RUS78412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZYM5"/>
    <dbReference type="STRING" id="188477.A0A3S0ZYM5"/>
    <dbReference type="OrthoDB" id="10005898at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026510">
        <property type="entry name" value="PEX11C_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20990">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20990:SF1">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 11C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS78412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="27487" checksum="6EF4F4E8DE796875" modified="2019-04-10" version="1">MGLMQNLTSIVSLLETYRGRDRVIRFLTYVAMFMGADGKTPAQIKWRTISGEMGACRVILRLFDDLPMLLMNLSTGFGLKDKRPLIRILNLLSAILNQGFYPSEHIAWLRQKKIMSGEARPYLLMGLFIWAVSLVVEVIKSLLKVHYINVQSVQLLKQKELDKSSDDASSSQNAEIKKTLSRLSDERSDAGLTILHSCCDLINAISWLPPGLLWAGSLTPRANGIFGMIATVVMFYRNWPPPKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A0C8</accession>
    <name>A0A3S1A0C8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_012754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000448">
        <property type="protein sequence ID" value="RUS79486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A0C8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018672364" description="EGF-like domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS79486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="12970" checksum="AF4E1F01C1F61709" modified="2019-04-10" version="1">MSKVGFAIWFLLASNFLLVSGRDWLDTYGYECQGTCLNGGRLYKFSEISTDTRKICKCQKSFFGPCCGIKTEDALMYSDYASGGTKLHPQSVIGCLVFGGLLQWLLQGLLGRRAIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A239</accession>
    <name>A0A3S1A239_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphodiesterase</fullName>
            <ecNumber evidence="9">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_000316</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="9">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="9"/>
    <dbReference type="EMBL" id="RQTK01000004">
        <property type="protein sequence ID" value="RUS91914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A239"/>
    <dbReference type="STRING" id="188477.A0A3S1A239"/>
    <dbReference type="OrthoDB" id="189220at2759"/>
    <dbReference type="UniPathway" id="UPA00762">
        <property type="reaction ID" value="UER00747"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006198">
        <property type="term" value="P:cAMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057304">
        <property type="entry name" value="PDE8-like_REC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23198">
        <property type="entry name" value="PDE8A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0114">cAMP</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="10">
        <location>
            <begin position="142"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="PDEase" evidence="11">
        <location>
            <begin position="412"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="488"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="488"/>
            <end position="492"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="528"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="529"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="529"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="529"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="630"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="630"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="682"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS91914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="737" mass="83658" checksum="A3545C4F6129C7AA" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A393</accession>
    <name>A0A3S1A393_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Neurotransmitter-gated ion-channel ligand-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">EGW08_010648</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">EC2010</strain>
            <tissue evidence="18">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Synaptic cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000328">
        <property type="protein sequence ID" value="RUS81596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A393"/>
    <dbReference type="STRING" id="188477.A0A3S1A393"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18997">
        <property type="entry name" value="LGIC_ECD_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000043">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000016">
        <property type="entry name" value="Nicotinic acetylcholine receptor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="16">
        <location>
            <begin position="6"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="17">
        <location>
            <begin position="192"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RUS81596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="462" mass="52224" checksum="D337B507A7715EA6" modified="2019-04-10" version="1" fragment="single">MQVKCTLKGVKIEDERNQVMTTNVWLDQEWRDEKFQWDPADFNGLKVLRMPCRHIWKPDIVLYNSVEDYTDGYMQSLAMVHSDGTVFWPPIVRFQSTCKIDITFFPFDDQLCKMKLGSWAYDGFQVDVYNRTVPVDLSNYVSNGEWQLMSVKAQRNVVYYPCCPEPFPDVIFTIHLRRRTLYYTYNVIAYNVIIPCVMLSCLTLLVFWMSPTSGEKVTLGLTVLLAFSVFMLLIAENMPATSNFVPLIGMYITSVMGITSLSVVLAVLVSNISQGGRNERTVPRGLHLMTVYLARAMCMRLHYLSAQQASQNSTTPSSGHSGSRAPNLSEKTAMLAAKSANNSRARRSFYKVGHGFQVSNDSGCGLIDFEMGDIGSPAAAQRTAAEDLAKTNCKDIDMILALLKSIMVKESEKERVDMIRLQWEEVAIIVDRFLFYIFLALTLVATLTTLVIMPLLKPTEPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A671</accession>
    <name>A0A3S1A671_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RBPJ-interacting and tubulin-associated protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">RBPJ-interacting and tubulin-associated protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_000622</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with RBPJ/RBPSUH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RITA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000008">
        <property type="protein sequence ID" value="RUS91649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A671"/>
    <dbReference type="STRING" id="188477.A0A3S1A671"/>
    <dbReference type="OrthoDB" id="10061257at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045746">
        <property type="term" value="P:negative regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051168">
        <property type="term" value="P:nuclear export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031418">
        <property type="entry name" value="RITA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34917">
        <property type="entry name" value="RBPJ-INTERACTING AND TUBULIN-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34917:SF1">
        <property type="entry name" value="RBPJ-INTERACTING AND TUBULIN-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17066">
        <property type="entry name" value="RITA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="8" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="179"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS91649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="221" mass="25015" checksum="B64CE2C0D5ECDF3C" modified="2019-04-10" version="1">MSNDFVVMGTRPPSALSSYRPVSAGRKHNGYHSRAQPSFVDESLFGSQHHTRLDEEFMSFKAPWEYPKPPPPRNTFAAPPKSKLPVKPKPKGRPLLWCPSPDAAVHVRTKTTKNLAHSDGAKSNQGALWNTRNNFRHLKHTPTFVDESLFGPRLQEPTFEAPWNERKKGEKRTVRPFLFYPSSGSTAKNGFKQRPATALGLSKRDTRNQQTSSSQRQVWKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A962</accession>
    <name>A0A3S1A962_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_006399</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000158">
        <property type="protein sequence ID" value="RUS85847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A962"/>
    <dbReference type="OrthoDB" id="205623at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="4">
        <location>
            <begin position="88"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS85847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="323" mass="36980" checksum="B501AFB142225686" modified="2019-04-10" version="1">MGVLKVVKKQFLSFIIFTGIMNLILSTLKPFISSIMTFLVRNQKIMLSNYQVVDASGKTMNMVRLNGKVYPPFGEDNIRKVSTLSIRDDDVLLCGYPKTGCHWMYEVISMLLRGKAELSPHGKGFGGMIEAVPEILLDSLPSPRVLNSHLLYAELPKQIREKKTKIILTTRNPKDTVVSFYNHHLALKNFYGYDGSFTDYFNLFLNGRLDYGDFFDHVLDWKKTKKNQSCNQILIVPFEDMKLDPFKCVYEIADFLKIKVTEKLAGEIIDACSFNRMKKKRAKDGPAAKLFRKGIVGDWKNWMSTEQSAAIDKRWAQTMQNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A9A7</accession>
    <name>A0A3S1A9A7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CARD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_006342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000156">
        <property type="protein sequence ID" value="RUS85939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A9A7"/>
    <dbReference type="OrthoDB" id="10031931at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070513">
        <property type="term" value="F:death domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01671">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037939">
        <property type="entry name" value="CRADD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15034">
        <property type="entry name" value="DEATH DOMAIN-CONTAINING PROTEIN CRADD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15034:SF5">
        <property type="entry name" value="DEATH DOMAIN-CONTAINING PROTEIN CRADD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00619">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00114">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50209">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CARD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="CARD" evidence="2">
        <location>
            <begin position="138"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS85939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="408" mass="44875" checksum="30D8C20A954D2ADD" modified="2019-04-10" version="1">MLKRHQLLLSKNYEFLVMEIPMDPTLEALRSRKVLTSHDFEQLRTLRHQGRRALARYLLAVLPVRGPNAFKALLESLQEANAQHLVDLLVAQSGAENVEQLIKIPPAEGGPPRTPSDTPLPAGPDPHEYAVRLARNNKLIREFVDPSSISPVLAQNKVISAREADMVLHLNGKNKKWDLILSAILQRGERAYQAFMAALLQKNYSTMFHTIQETPTVGSDTDPDLDNDDYNTSGDEDDVDDTIDSINKASQTHPLNSDHFEESDDELKAEAIASVMARNRNVADADTQTRGYTPNHALLNGSRDLQDDGVPPTPQNRNGSRISQRSNSGPVNNQNGDDNVSNNGEQIPTGQNSARPDTSNSMQSNGAPPPSNTQDNPAANKSPSKSQRRRSSAAGNLNSLQEEDESSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AAJ9</accession>
    <name>A0A3S1AAJ9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_005418</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000127">
        <property type="protein sequence ID" value="RUS86822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AAJ9"/>
    <dbReference type="STRING" id="188477.A0A3S1AAJ9"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18238">
        <property type="entry name" value="BTB_POZ_KLHL8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF480">
        <property type="entry name" value="KELCH-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="32"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS86822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="593" mass="66754" checksum="EB7F3389F5050352" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AEK3</accession>
    <name>A0A3S1AEK3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Receptor protein-tyrosine kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_002364</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000046">
        <property type="protein sequence ID" value="RUS89834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S1AEK3"/>
    <dbReference type="OrthoDB" id="6140652at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002602">
        <property type="entry name" value="DB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050991">
        <property type="entry name" value="ECM_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708:SF2">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708">
        <property type="entry name" value="TENASCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01682">
        <property type="entry name" value="DB"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018726195" description="Receptor protein-tyrosine kinase" evidence="3">
        <location>
            <begin position="25"/>
            <end position="1723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1579"/>
            <end position="1604"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="30"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="247"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="455"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="665"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="880"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="961"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="1063"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="1286"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="1383"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="1473"/>
            <end position="1562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS89834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1723" mass="189239" checksum="72E056E3ED71A54C" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AQ90</accession>
    <name>A0A3S1AQ90_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">VTT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_023332</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001933">
        <property type="protein sequence ID" value="RUS68909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AQ90"/>
    <dbReference type="STRING" id="188477.A0A3S1AQ90"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015414">
        <property type="entry name" value="TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12677">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12677:SF59">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="7">
        <location>
            <begin position="26"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS68909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="183" mass="20950" checksum="D7DD25F1E55293B4" modified="2019-04-10" version="1" fragment="single">YVDVHYYLSLLIFICIYILCVFLSIPIKPFLKMLAGLVFGLFLGFIASLISATIGAMLIFLLIKYSWGETPKSYKNRLLDQFSLLVDKYPIRILIFSRLMPIPFFIPNIAAAILKVKNSIFFFCTLIGIIPMTFIYVWLGTHVNNTVFSDSSNFIDSKLIVAIVVILMMALTPVLLKFRCFYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AV30</accession>
    <name>A0A3S1AV30_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">F-actin cross-linking protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_019239</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-actinin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000988">
        <property type="protein sequence ID" value="RUS72991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AV30"/>
    <dbReference type="STRING" id="188477.A0A3S1AV30"/>
    <dbReference type="OrthoDB" id="18853at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21214">
        <property type="entry name" value="CH_ACTN_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21216">
        <property type="entry name" value="CH_ACTN_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000004">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000001">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000004">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000005">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000005">
        <property type="entry name" value="Actinin alpha 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000002">
        <property type="entry name" value="Actinin, alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000148">
        <property type="entry name" value="alpha-actinin, sarcomeric isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014837">
        <property type="entry name" value="EF-hand_Ca_insen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08726">
        <property type="entry name" value="EFhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="9">
        <location>
            <begin position="26"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="9">
        <location>
            <begin position="141"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="679"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="720"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="262"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS72991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="825" mass="95753" checksum="B14F062DFD96488E" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AVF1</accession>
    <name>A0A3S1AVF1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_018989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000960">
        <property type="protein sequence ID" value="RUS73246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AVF1"/>
    <dbReference type="OrthoDB" id="10016177at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS73246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="458" mass="53304" checksum="5DD4E5BD0F8A6F45" modified="2019-04-10" version="1">MRGKGVGGGYAKRRYKPQPYASPVQTYSHIPQVVYGAPFPVYYPPPPRGSKDARKAQARRQDKNRGYRDIHTARKSARLTQSGFPIPKRRKGGRQSQAHRSMPMFAAPFPMMPMPMPMMYQPMLEEEEEEEDTDEMTREAFSHWRKHPLFAQDFTDWFIQDCIDTDILPDFLIDMLKVMKHMPYDHPLYLPSLYSCEDLLSDHVSELVVDIVREALAEAANDYMDEKRLEKDPLEDFLNDLIEDAVRLGVRETVRDTVVHMAEDYVEEEYATTIIHDLLDDHMDEIGEELLEDTIFDIMAEDFIEREVIASEIKEELQIVAKEVLDHYDSKVLKREFREVSQKATVKLADSFLMTYMMSVVSQQGKIWTEDDHYNRHLDDMIFNTSMLQMFSVRKQRDKTLDSKPLQKLHERVVSDVALDVFLQQLTRSLDEDLADVDEWERGVMDGAANPVPLLAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AY37</accession>
    <name>A0A3S1AY37_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fucolectin tachylectin-4 pentraxin-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_017010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000761">
        <property type="protein sequence ID" value="RUS75220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AY37"/>
    <dbReference type="OrthoDB" id="6157064at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006585">
        <property type="entry name" value="FTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22633">
        <property type="entry name" value="F5_F8_type_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00607">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018576590" description="Fucolectin tachylectin-4 pentraxin-1 domain-containing protein" evidence="6">
        <location>
            <begin position="27"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="489"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Fucolectin tachylectin-4 pentraxin-1" evidence="7">
        <location>
            <begin position="188"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS75220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="572" mass="62218" checksum="E621FB21FADC195C" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AZ43</accession>
    <name>A0A3S1AZ43_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_016402</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000708">
        <property type="protein sequence ID" value="RUS75833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AZ43"/>
    <dbReference type="STRING" id="188477.A0A3S1AZ43"/>
    <dbReference type="OrthoDB" id="9990906at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF25">
        <property type="entry name" value="CNMAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="229"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="528"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="530"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS75833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="575" mass="61908" checksum="1F456058E09F7D6B" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AZC5</accession>
    <name>A0A3S1AZC5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein uS7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_021154</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001276">
        <property type="protein sequence ID" value="RUS71076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AZC5"/>
    <dbReference type="STRING" id="188477.A0A3S1AZC5"/>
    <dbReference type="OrthoDB" id="10264639at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.455.10:FF:000003">
        <property type="entry name" value="40S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_uS7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_uS7_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003106">
        <property type="entry name" value="PRK04027.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="5">
        <location>
            <begin position="56"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS71076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="213" mass="23695" checksum="08C2788330DBDF1F" modified="2019-04-10" version="1">MSEDWAEEAAATTGGPAVAVTELPEIKLFGKWSTDEVQVSDISLTDYIAVKEKFAKYLPHSAGRYQVKRFRKAMCPIVERLVSSLMMHGRNNGKKLMAVRIVKHSFEIIYLLTGENPLQILVNAIINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWMLCTGSREAAFRNIKTIAECLADELINAAKGSSNSHAIKKKDELERVAKSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AZE3</accession>
    <name>A0A3S1AZE3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_021123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001270">
        <property type="protein sequence ID" value="RUS71118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AZE3"/>
    <dbReference type="OrthoDB" id="6156720at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="613"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="538"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS71118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="692" mass="79538" checksum="6565BC1AE1B5000F" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B005</accession>
    <name>A0A3S1B005_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CWH43-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_020716</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DRAM/TMEM150 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001202">
        <property type="protein sequence ID" value="RUS71518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B005"/>
    <dbReference type="OrthoDB" id="6146563at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050911">
        <property type="entry name" value="DRAM/TMEM150_Autophagy_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324:SF2">
        <property type="entry name" value="EG:22E5.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324">
        <property type="entry name" value="FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS71518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="160" mass="17958" checksum="616A9A6C79A11E19" modified="2019-04-10" version="1">MQTALSYHMYPRYNGVLICRVRLFISLLCVAACVIMSVSGAIAFRKWQADPPSHKRYKWQPDDPGFIPHIFSTVTEWVLSFGFFCFFLTYVREFNKFEMEVVTRPLVTHLDLFPGESGPSLAGGGHCPQAGLEGHLNSGYQSGSGEPDERTKLLGLKSFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B2N3</accession>
    <name>A0A3S1B2N3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_021819</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001413">
        <property type="protein sequence ID" value="RUS70420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B2N3"/>
    <dbReference type="STRING" id="188477.A0A3S1B2N3"/>
    <dbReference type="OrthoDB" id="1658724at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="7">
        <location>
            <begin position="149"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS70420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="311" mass="36193" checksum="7B3B78C77AFAA0EE" modified="2019-04-10" version="1">MLNASHSASAFGAGGNSSNLSTVPDPGEALLSREPRFLQPLWELRLGYEEYLQSPLFPVVLSVFHYFGLCIPVTFVDVFCKRHKWYNKYKIQPDKEITAAQLRDTLTLTMWNHVLFIMPAAMAQWVWTPSSPLPEMAPTLADFLWHQIAGLFIFDFQYFVWHMMHHKVRFLYRHIHAVHHRYNSPFVWVTQYLHPWELVVAGFLTTTNTWFFDSHPLTVWSYMVVSITISVEAHVGFDFPFSMHRLDPTGNFGGSPKHDMHHQKPLTNFEPFFNHFDKMFGSFCPPMGPGGTKSKALTDYERRARECKKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B3X4</accession>
    <name>A0A3S1B3X4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Outer dynein arm-docking complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Tetratricopeptide repeat protein 25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_017829</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000833">
        <property type="protein sequence ID" value="RUS74411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B3X4"/>
    <dbReference type="STRING" id="188477.A0A3S1B3X4"/>
    <dbReference type="OrthoDB" id="6127047at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040111">
        <property type="entry name" value="ODAD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="35"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="590"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="93"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="287"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="340"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="605"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS74411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="616" mass="70544" checksum="1B498CED3C830AFA" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B6E5</accession>
    <name>A0A3S1B6E5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_019043</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000966">
        <property type="protein sequence ID" value="RUS73197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B6E5"/>
    <dbReference type="STRING" id="188477.A0A3S1B6E5"/>
    <dbReference type="OrthoDB" id="9990906at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF25">
        <property type="entry name" value="CNMAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="19"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS73197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="125" mass="14112" checksum="03323E59B1B2C044" modified="2019-04-10" version="1" fragment="single">MELVDYYTSPLIMVLGVLSNVLAYAVFTRTRLRKVASVPYLAAMAVTDSGALITDFIQKGLVKHDIFIISRSGICQFTTYFSYVFIFLSIWYPLAVCVEKFICVYYPLRKASLCTPFRAKVVVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B756</accession>
    <name>A0A3S1B756_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_010824</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000338">
        <property type="protein sequence ID" value="RUS81440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B756"/>
    <dbReference type="STRING" id="188477.A0A3S1B756"/>
    <dbReference type="OrthoDB" id="10027888at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS81440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="275" mass="30437" checksum="EE6CE8F6DB9F86F0" modified="2019-04-10" version="1">MPVNHFYHTMQNQILGGRSPSAPKAGPLDIKQYFVSTEVTTPKSGDFSSLTSAKRHRHFSYGSATCASGYDYVLKIILLGDQGVGKSSYLKALRVHPELTKIKCKCRLSQMCDHLEIEVITSNGKMALVKLCDTGGQERYRSLTSSYYRGAHGAILVMSLKNSASLDSIEQWLADLDTFCSASSCSRVLLGTNCSSPARAIPPESGRLFAESRALPYMEIDTSHYFNVVESLQLIVDRIVREVTISTTKSLVIKPSSRSDEELRKMEAKKYVCLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B8V7</accession>
    <name>A0A3S1B8V7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Profilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_014360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the profilin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000545">
        <property type="protein sequence ID" value="RUS77886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B8V7"/>
    <dbReference type="STRING" id="188477.A0A3S1B8V7"/>
    <dbReference type="OrthoDB" id="421374at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048278">
        <property type="entry name" value="PFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005455">
        <property type="entry name" value="PFN_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036140">
        <property type="entry name" value="PFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027310">
        <property type="entry name" value="Profilin_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00235">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00392">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55770">
        <property type="entry name" value="Profilin (actin-binding protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00414">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS77886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="138" mass="14838" checksum="C543300BCE1E9720" modified="2019-04-10" version="1">MSWNSYVETLEKGVCKYAAIVGRTDDSSPLAVWAESADKSSLNPGAAELISAATSVVKNDNSVMGNGIVLGGVKFACIRFEMDTLICQGKADCKDYSLIFSSTGKVCLIGFNPDAEVKTPKVREAVDNMRDWLKNAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B962</accession>
    <name>A0A3S1B962_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Focadhesin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_009493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000273">
        <property type="protein sequence ID" value="RUS82755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B962"/>
    <dbReference type="STRING" id="188477.A0A3S1B962"/>
    <dbReference type="OrthoDB" id="6125419at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060147">
        <property type="term" value="P:regulation of post-transcriptional gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045163">
        <property type="entry name" value="Focadhesin/RST1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021392">
        <property type="entry name" value="Focadhesin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16212:SF4">
        <property type="entry name" value="FOCADHESIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16212">
        <property type="entry name" value="FOCADHESIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11229">
        <property type="entry name" value="Focadhesin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Focadhesin C-terminal" evidence="1">
        <location>
            <begin position="237"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Focadhesin C-terminal" evidence="1">
        <location>
            <begin position="545"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS82755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="865" mass="93025" checksum="A85E78777CFCD4F2" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BA61</accession>
    <name>A0A3S1BA61_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_012877</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000456">
        <property type="protein sequence ID" value="RUS79356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BA61"/>
    <dbReference type="STRING" id="188477.A0A3S1BA61"/>
    <dbReference type="OrthoDB" id="2596881at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000837">
        <property type="entry name" value="AP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351:SF24">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351">
        <property type="entry name" value="FOS TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="162"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="511"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="551"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="693"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="194"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="511"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="766"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS79356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="811" mass="86977" checksum="073F3A9210ABA3F7" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BAV1</accession>
    <name>A0A3S1BAV1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_013097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000468">
        <property type="protein sequence ID" value="RUS79150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BAV1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS79150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="107" mass="12573" checksum="761C680FE3058621" modified="2019-04-10" version="1">MTNICRLVTTENLGCNSHIVLTVFFSWLRFLRTPSYSNIIVTCFFCRLQFLRAHSYYGTILTGFFCKFIFLQAHPYFGLLCLLFEHWFPFADAALWGAWFGGRGRQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BBP7</accession>
    <name>A0A3S1BBP7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_015370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000628">
        <property type="protein sequence ID" value="RUS76860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BBP7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS76860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="16939" checksum="188D20D677E2797D" modified="2019-04-10" version="1">MGASYFQEIDAVLWDDGTDLRSDTPFGMFPPQAHPNNPCGKFIIDGSFRMGDVYLLSYGMCGNHNPPKRVTYGRTLKNQQLITTVKTVLAEYQVNYYVECVMRCSAWYKCRAAEFHNDSLNCSIIGEFTSNGTTAYPHLTTFFRQTFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BBV0</accession>
    <name>A0A3S1BBV0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_015225</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000618">
        <property type="protein sequence ID" value="RUS77000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BBV0"/>
    <dbReference type="STRING" id="188477.A0A3S1BBV0"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="294"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS77000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="596" mass="66786" checksum="B9A6ADEB0CA5309C" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BFF5</accession>
    <name>A0A3S1BFF5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_012698</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000445">
        <property type="protein sequence ID" value="RUS79530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BFF5"/>
    <dbReference type="STRING" id="188477.A0A3S1BFF5"/>
    <dbReference type="OrthoDB" id="414418at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07040">
        <property type="entry name" value="HP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051710">
        <property type="entry name" value="Phosphatase_SH3-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469:SF27">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="3">
        <location>
            <begin position="51"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS79530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="473" mass="53648" checksum="29AB437A94463AF6" modified="2019-04-10" version="1" fragment="single">MKPQLKQLHMTLAFQYAAEKHDALMRMAEKIDPQCSAHWEIQVFSRDAAVKSAEVRRVLKNYKPQQADELELQTEDFVFMEPEEHKTSPDGWFKGTSWRSGLSAFFPGNFTSQCAQMEVWTLHRYVTLPNFVSAQKEDTLKRQNGWKKAQASLPPEQMEVDAPELVVSLPEKAQSSSGEYDNVWGISEDVSRLYAKVNKPDTKSSAPEVQRPPRKLLISRHGERCDFAFYKTWFDKSFDEEGRYSRMNLNCPKFLVSRSSYKDFSKDAPLTLIGRQQARITGEALLDAGQYVTSVYCSPSLRCVETATEILKGMRSPCRLRVEPCLYEWAGWCKPIPQFMSPMELEANGFPVDSQYTPYLTPAEISLSESVADYYSRSYSFTRTIMQKHRAEGGTFLFVGHSGSLDACTRQMLGHQPRDPGGFRDCIRGCPYCALCCMEEDSGIAGAVGGGWRTAERSPSDGDRWRLVEPPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BFM2</accession>
    <name>A0A3S1BFM2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cyclin-dependent kinase</fullName>
            <ecNumber evidence="3">2.7.11.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Galactosyltransferase-associated protein kinase p58/GTA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EGW08_009379</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">EC2010</strain>
            <tissue evidence="16">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="3"/>
    <dbReference type="EMBL" id="RQTK01000268">
        <property type="protein sequence ID" value="RUS82857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BFM2"/>
    <dbReference type="STRING" id="188477.A0A3S1BFM2"/>
    <dbReference type="OrthoDB" id="647at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07843">
        <property type="entry name" value="STKc_CDC2L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000054">
        <property type="entry name" value="Cyclin-dependent kinase 11B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000124">
        <property type="entry name" value="cyclin-dependent kinase 11B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045267">
        <property type="entry name" value="CDK11/PITSLRE_STKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="490"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="786"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="118"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="277"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="293"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="328"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="361"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="453"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00079859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RUS82857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="848" mass="96905" checksum="E2A5930918C350E3" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BFU6</accession>
    <name>A0A3S1BFU6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_009252</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000263">
        <property type="protein sequence ID" value="RUS82967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6107827at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="entry name" value="Glucose Permease (Domain IIA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.230.10">
        <property type="entry name" value="Lipovitellin, beta-sheet shell regions, chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015819">
        <property type="entry name" value="Lipid_transp_b-sht_shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015816">
        <property type="entry name" value="Vitellinogen_b-sht_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56968">
        <property type="entry name" value="Lipovitellin-phosvitin complex, beta-sheet shell regions"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="1355"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="1578"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="1634"/>
            <end position="1655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1175"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1592"/>
            <end position="1650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1175"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1609"/>
            <end position="1625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1636"/>
            <end position="1646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS82967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="2150" mass="237865" checksum="32200E0B7C444228" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BGT9</accession>
    <name>A0A3S1BGT9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_011829</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IER family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000392">
        <property type="protein sequence ID" value="RUS80417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BGT9"/>
    <dbReference type="STRING" id="188477.A0A3S1BGT9"/>
    <dbReference type="OrthoDB" id="6358394at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008653">
        <property type="entry name" value="IER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15895">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05760">
        <property type="entry name" value="IER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="259"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS80417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="389" mass="41353" checksum="870C7712F1E66DED" modified="2019-04-10" version="1">MAANVESQRLISLSLGKIAQSRSQKGGINLHKNLLVATVLHKARTACMMEYQSLQRQRQLEYQQRQQQQHRDAAALEFEAKQEQARSAALSLAAFNTSEPPQPEHSVIPTCVREMEEQHQSTSGAPACDLVTPASGVNLGQSCETAAPALDKLGQPLDLVELSQTTGADSCDKENFPPTCVSVECESSVEEDLEEDVEDDTSAQVVPQSAVLPTHVDHLVAATQLAEDAAGLSSSWKQQTSAAPTCNVLKRQRENWGSSCQEQECPPATKKARLVATPSASRRDSCSSRSSNSASDADQHSISTDSSQISNLVSIFNSGFSGLCAVSSLTSSSSSSSLSNEDLSSSSCENVSAQYNQSDSMSMSPSLSCSSSMGRMDSLPSALGLVLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BMP4</accession>
    <name>A0A3S1BMP4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_000389</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="RQTK01000005">
        <property type="protein sequence ID" value="RUS91818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BMP4"/>
    <dbReference type="STRING" id="188477.A0A3S1BMP4"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033550">
        <property type="term" value="F:MAP kinase tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008330">
        <property type="term" value="F:protein tyrosine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF519">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="411"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="489"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="99"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="246"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS91818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="620" mass="67928" checksum="F478B52DA3413759" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BQW8</accession>
    <name>A0A3S1BQW8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Synergin gamma C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_002890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000058">
        <property type="protein sequence ID" value="RUS89370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BQW8"/>
    <dbReference type="STRING" id="188477.A0A3S1BQW8"/>
    <dbReference type="OrthoDB" id="524326at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039656">
        <property type="entry name" value="SYNRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059024">
        <property type="entry name" value="SYNRG_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15463">
        <property type="entry name" value="AP1 GAMMA SUBUNIT BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15463:SF2">
        <property type="entry name" value="SYNERGIN GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25999">
        <property type="entry name" value="SYNRG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Synergin gamma C-terminal" evidence="2">
        <location>
            <begin position="554"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="478"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS89370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="737" mass="81032" checksum="7B03A232F61CB039" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BTV0</accession>
    <name>A0A3S1BTV0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Choice-of-anchor I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_003698</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000080">
        <property type="protein sequence ID" value="RUS88522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BTV0"/>
    <dbReference type="OrthoDB" id="6068742at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055188">
        <property type="entry name" value="Choice_anch_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052956">
        <property type="entry name" value="Mesenchyme-surface_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46928">
        <property type="entry name" value="MESENCHYME-SPECIFIC CELL SURFACE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46928:SF1">
        <property type="entry name" value="MESENCHYME-SPECIFIC CELL SURFACE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22494">
        <property type="entry name" value="choice_anch_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018694497" description="Choice-of-anchor I domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="Choice-of-anchor I" evidence="2">
        <location>
            <begin position="236"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS88522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="581" mass="63605" checksum="91120F730E7B7798" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BVS2</accession>
    <name>A0A3S1BVS2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_016169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000689">
        <property type="protein sequence ID" value="RUS76065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BVS2"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS76065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="151" mass="17465" checksum="F8F9139BAF7EED0E" modified="2019-04-10" version="1">MLTTTNHPYHHAHNNKSSISSCSQQQIIHNAFDQISFTMFFMLSSFRLMYAVFRQVSSTMSFVKSFPYCSSWLIHTALHKLLTTYLCSYCPHISAALIPISLYIIHIYLQVFFIYLCTFVSHLLMADQQISANLIYRKVISLCLVDVTVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BYR7</accession>
    <name>A0A3S1BYR7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Replication factor C subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Activator 1 38 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Activator 1 subunit 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Replication factor C 38 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_013830</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Subunit of the RFC complex, an heteropentameric complex consisting of a large subunit RFC1 and four small subunits RFC2, RFC3, RFC4 and RFC5; the RFC complex interacts with PCNA. Forms an heterotetrameric complex with RFC2, RFC4 and RFC5; this complex has ATPase activity but is not stimulated by PCNA. The heterotetramer of subunits RFC2, RFC3, RFC4 and RFC5 interacts with RAD17. Interacts with CNTD1; this interaction facilitates crossover formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000511">
        <property type="protein sequence ID" value="RUS78416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BYR7"/>
    <dbReference type="STRING" id="188477.A0A3S1BYR7"/>
    <dbReference type="OrthoDB" id="761538at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000030">
        <property type="entry name" value="replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000002">
        <property type="entry name" value="Replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000136">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF1">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13177">
        <property type="entry name" value="DNA_pol3_delta2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22534">
        <property type="entry name" value="RFC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="34"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00058626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00062267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00079394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00080379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS78416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="355" mass="40550" checksum="76B18A871A66C056" modified="2019-04-10" version="1">MSLWVDKYRPTTLGKLDYHKDQAAHLRKLVEGGDFPHLLVYGPSGAGKKTRIMCTLRELYGPGVEKLRIEQSQFTTPSNKKLDISTISSNYHIEVNPSDVGHNDRVVIQELIKNVAQVNQLDTSTQKNFKVVVLTEVDRLSKEAQHALRRTMEKYMATCRLILCCNSTSKVIPAIRSRCLGLRVAAPSVDEICQILTSVCKKEGLTLPREMAEKVAEKSGRNLRRALLMCEACRVQQYPFNPEREVSEPDWEVYLRETATMIAQQQSPKRLLEVRGRLYELLTHCIPPDVIMKGLLRELVQVCDGQMKPEVVQNAAYYEHRLQQGQKAIYHLEAFVAKFMAIYKRFLEEGIADIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C5Z6</accession>
    <name>A0A3S1C5Z6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_008375</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000226">
        <property type="protein sequence ID" value="RUS83894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C5Z6"/>
    <dbReference type="STRING" id="188477.A0A3S1C5Z6"/>
    <dbReference type="OrthoDB" id="5965749at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF372">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="393"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="63"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS83894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="471" mass="51846" checksum="78AAED92708A898D" modified="2019-04-10" version="1">MIGAFGSPFYNMTADAGNNSINVSLSARSESGPAVLGCEANDLYGSPVVAVVAVLIGIALMGENLLMISVICRYQSLHTNTNILVASLAFSDVWIGFQCIVMGLISLPDGLRSWLALRQSEMRVLYAFLTGVNMGLIVVSMAHLAVLSLDRYLFVLWPFQYSRRVTQRRVIVTALGIWTVGCTYMSLPLMLYLDPKCHVKCFIFEAPVEYAGWPVVCVHFTCLTIVTVSTAGLARIAFKHGQKRGQLRNGDSLENYTCSGKSYMNKGNSLEMLKISTISPGEVSAATVHTNNNTKSSTVSAVNQGSEKLAIATHKQARSGKTKAGCLAVIDNYNEVRDLNMGRYEDQEAHNTSVQDTEIRNVDHSSPRTVVNFQDNADGEKNKTSNRSNKLKILKLLVLIVGCYIVCSFPAVLMMIVDDIAQVYRFSNFAQQASGLMFITSSGMNFIIMANFKTDFRDALRTFFHCSKRCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H086</accession>
    <name>A0A3S1H086_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_022594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001615">
        <property type="protein sequence ID" value="RUS69643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H086"/>
    <dbReference type="STRING" id="188477.A0A3S1H086"/>
    <dbReference type="OrthoDB" id="6142323at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="55"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS69643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="35193" checksum="E04DDD0E5788EBDA" modified="2019-04-10" version="1">MWGGRFEVYTALGILRDIEFLHASESCLGTKQRKRNEWISAETWETIEDRKDLKRKAMETKSERLKEQYREKYREADKTVKRKTRVDQRAFIYDLASQDEEAAGRGEQGQVYKITKIVAGKYRGTSNAPITDKQGLLLTTKSEQEARWTEHFREILNRPPPKTAVDIHFAEVDLDINTEPPEKAEIERAIKSLKSGKAPGQDNLNAELFKVDPPLAAEIIKPLFTSIWGKKELPKDWTEGIIVKIPKKGTRSDCNNWRGITLLSIPSKILSKIIIQRISEAVNQQLINEQAGRGCCDQIFTLRNIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HBV6</accession>
    <name>A0A3S1HBV6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Abnormal spindle-like microcephaly-associated protein ASH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_016057</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000682">
        <property type="protein sequence ID" value="RUS76179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HBV6"/>
    <dbReference type="STRING" id="188477.A0A3S1HBV6"/>
    <dbReference type="OrthoDB" id="5538672at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097729">
        <property type="term" value="C:9+2 motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044458">
        <property type="term" value="P:motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029676">
        <property type="entry name" value="CFAP221"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46500">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46500:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24771">
        <property type="entry name" value="Ig_CFAP74_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS76179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="835" mass="95337" checksum="B4091E0A2B626226" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HPB5</accession>
    <name>A0A3S1HPB5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_008740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000241">
        <property type="protein sequence ID" value="RUS83490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HPB5"/>
    <dbReference type="OrthoDB" id="6142625at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018605673" evidence="2">
        <location>
            <begin position="20"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS83490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="166" mass="18163" checksum="4F84043F8D95B349" modified="2019-04-10" version="1" fragment="single">MKLLIGLAVLVATTVLVRADFVTFLKEIQSHQDFQTLSTDDKTLFFELVMAAETDTLTELIDRVGLLSVLELVDALSYADASKFSAYLAESLGYHHHKPTNSDVITKRSLAKRDDDSGSDSASSDEDDDNARSSQDNLNGSEQRVWSQIQAAGTDGLADLIAETDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HV09</accession>
    <name>A0A3S1HV09_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenosine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_005581</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>adenosine + H2O + H(+) = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="4"/>
    <dbReference type="EMBL" id="RQTK01000132">
        <property type="protein sequence ID" value="RUS86632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HV09"/>
    <dbReference type="STRING" id="188477.A0A3S1HV09"/>
    <dbReference type="OrthoDB" id="7202371at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000017">
        <property type="entry name" value="Adenosine deaminase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013659">
        <property type="entry name" value="A_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006331">
        <property type="entry name" value="ADGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01431">
        <property type="entry name" value="adm_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF39">
        <property type="entry name" value="ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08451">
        <property type="entry name" value="A_deaminase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018789997" description="adenosine deaminase" evidence="10">
        <location>
            <begin position="24"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Adenosine/AMP deaminase N-terminal" evidence="12">
        <location>
            <begin position="21"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Adenosine deaminase" evidence="11">
        <location>
            <begin position="198"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS86632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="512" mass="58497" checksum="FBD74811C2165643" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HVD7</accession>
    <name>A0A3S1HVD7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SOCS box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_005431</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000127">
        <property type="protein sequence ID" value="RUS86835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HVD7"/>
    <dbReference type="STRING" id="188477.A0A3S1HVD7"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03587">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051637">
        <property type="entry name" value="Ank_repeat_dom-contain_49"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR 2C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180:SF45">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE TANKYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="72"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="107"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="140"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="231"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="4">
        <location>
            <begin position="368"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS86835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="418" mass="45656" checksum="C78CDD464BEEE50E" modified="2019-04-10" version="1">MSVLDCVNWKSISFQELDSLLRLQGDVDKVVVDDNQSYSITPLCVACKNNREDLVTVLLHHGAATEKRSSFYGKQPLHFACDHSCGNLGIVRKILDAKANIDAQDIDGNTALHLACTESNVPVVELLLERRADVHLMDIDGETPLVRACLARSHRLVEALLKATSDPNVGDGLPLEITVATGSVETLKSLIASGADVQRRAYLAQACEYNQIDVMKVLKNCGADLNKTNSLGKTPLQAACSSEQSSAEVVRLLLSWGADVNICSSTRMTAMHYACDRLYVEKVRLLLAYGADPGMRWAHQMTPIEQAWIGFLLGRHESQDIDCSIVQVVRLLLAAGARLRPGFRHLRSAIVLTPGLGPRAIQELLDLLECQASGPAKLQDLCRICVRNATNPNIDVNVAALPLPKPIVSYLQFDDIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HWX1</accession>
    <name>A0A3S1HWX1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_004446</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000101">
        <property type="protein sequence ID" value="RUS87781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HWX1"/>
    <dbReference type="STRING" id="188477.A0A3S1HWX1"/>
    <dbReference type="OrthoDB" id="3213154at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21980">
        <property type="entry name" value="HMG-box_HMG20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051965">
        <property type="entry name" value="ChromReg_NeuronalGeneExpr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46040">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46040:SF3">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00886">
        <property type="entry name" value="HIGHMOBLTY12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="169"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="169"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="101"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS87781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="350" mass="39104" checksum="1FD6ABA94CFA79EA" modified="2019-04-10" version="1" fragment="single">DFSSDDCGRSVIAIPNLPTGTPGSILEKETEITLNSSFIPENAVLMETSRGLMLTVPENINAISYVGDSPPVEQSQQLLSCIPVSLFSACDTAADVDSGGDYGTELSNGTDNNSQVQENHHKNTHDSNNEIATEQPLTDEATEICVTTKRKGGWPKGKKRKIKPVVTGPRAPVTGYTLYAMDRRKEIKESHPEIAFPEVTKILGQEWSTMAQDVKQKYLEAAEEDKKRYREELKAYRSSDTYQETVRKKMLANGNLYFESVQKQGDSDELHCKLCNVYFNNLHNKREHMYGKAHIQNVAGAMEKQLLRQQQEEQAFMDGALVVSEDLSQDSYPSSTLKTNGYHGERLCLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1I2I6</accession>
    <name>A0A3S1I2I6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_001289</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000021">
        <property type="protein sequence ID" value="RUS90985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1I2I6"/>
    <dbReference type="OrthoDB" id="6134459at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15039">
        <property type="entry name" value="7tmB3_Methuselah-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022343">
        <property type="entry name" value="GCR1-cAMP_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053231">
        <property type="entry name" value="GPCR_LN-TM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902:SF1">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02001">
        <property type="entry name" value="GCR1CAMPR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="6">
        <location>
            <begin position="7"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS90985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="291" mass="32847" checksum="7B49B2B62D16E375" modified="2019-04-10" version="1" fragment="single">FRLHQAEALITEILGQVSLVALFLVLLTYVLFPRLRNLPGINTMNLTFALLVAESIFSHGIDAKLPWLCTAIAVCLHYLFLAAHFWMNVMSYDVYRTFVSDVSGSVSMKRVKDKKKYVPLYSLYAWGTPLLIVAFCVFVDRSDLFPDITIGYGLSYCWITQPLAAFISFGAPILIIFIANCIFFARVITTISRTARLSKTRLQTQTSSSSLNNRQPGRADAWLYLRMSSVMGFTWIFGLSSSIVSSFSRPAFEICVISHTLGILFTIFNISQGIFIFGAFVCNRRVLNLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SI02</accession>
    <name>A0A433SI02_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_023831</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01003696">
        <property type="protein sequence ID" value="RUS68407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SI02"/>
    <dbReference type="OrthoDB" id="6132286at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS68407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="136" mass="15414" checksum="BA9D325E4B782F53" modified="2019-05-08" version="1" fragment="single">MAASKGKSTPIVVLAPREVPISKFYGDGGARDTRRFVEEVKAAWSAQRCETDQEKRGILWSHLGEEVRQELNCLLDGDTRDPQWMLVTIANNYGERRSVSCLLGAFHATRQRQGEGIRAFSHRLRDVFDALLGRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SMA3</accession>
    <name>A0A433SMA3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_021925</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001441">
        <property type="protein sequence ID" value="RUS70311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SMA3"/>
    <dbReference type="OrthoDB" id="6125674at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF240">
        <property type="entry name" value="BLOATED TUBULES, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS70311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="289" mass="32783" checksum="4C5EE877E44F2397" modified="2019-05-08" version="1">MSSEIPHWNAFQFVIICVYTCFLSFVQSPSGGLSVVAVYISLLVLAVPAVFVQLKLGGYLQTSMLSMFTKFFPIWKGCPVCLSVCLSVCLSVCLSVCLSVWEEDYLWGKCDKVQHMARKDEMCSLSKPDRFVTLDLIARRPEELFYLREFLQMSDSIEDMGGFPHWRFNELAHKAEMSLMPVTLAIVWVLVALVVGFGARLCGWVLFLLGPAAVGCLLTVLGYGFHHLDTEQAVIYLKNLYVFKDSDDEHILTIWTKNFKFLTYTFPLWSAICCTMGKLCGRSRKLRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SN14</accession>
    <name>A0A433SN14_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ETS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_021617</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ETS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001367">
        <property type="protein sequence ID" value="RUS70620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SN14"/>
    <dbReference type="STRING" id="188477.A0A433SN14"/>
    <dbReference type="OrthoDB" id="10067219at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000343">
        <property type="entry name" value="Ets at 65A, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF304">
        <property type="entry name" value="DNA-BINDING PROTEIN D-ETS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00345">
        <property type="entry name" value="ETS_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETS" evidence="7">
        <location>
            <begin position="120"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="33"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="77"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS70620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="319" mass="36028" checksum="491398E5C886A518" modified="2019-05-08" version="1">MQGLMQQDYYRACSTLSSLPGMMFSDTAYGKNAWSPQPSPQTQVPDPTFPKLSLPGPPAPVPKPYTPPFSSVGKTGLESSMHTASQWRSSQSYSTPLTPISKNPLDSSHAPWRPQGSGQIQLWQFLLELLSDSTNAACITWEGTQGEFKLVDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFAGLAQAMQPSSADPSAYKYQQDFLMSSYNYHHPHHPHHHHNHQKLNYLNPAPPISNTSPPGLFSPHSGYWPGTPASAANLYHNIPNHHHHPHPHPMPPHPGHMAPPLGPYYPYDRWEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SNC8</accession>
    <name>A0A433SNC8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_021517</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001345">
        <property type="protein sequence ID" value="RUS70726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SNC8"/>
    <dbReference type="OrthoDB" id="6162243at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050801">
        <property type="entry name" value="Ca-Dep_Lectins_ImmuneDev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801:SF63">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801">
        <property type="entry name" value="LITHOSTATHINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019186507" description="C-type lectin domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="44"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS70726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="282" mass="31692" checksum="ACB47AF98A5D6FDD" modified="2019-05-08" version="1">MFLHMLGLLLCVASPVICVNSLVETVCPPNVLQNVKNSTYFRVLNNTCFLFDTYSYVTYETARKMCLYSGGSLAMPKTKRINDFLLKQMEQISPLERMWIGMHDLENEGTWMWEDGSKVKSWGNMAFFNDGWFGFVDNCIALDASDGLWHDERCFLVLFPDKKLPYICEYSKIVVRHQHGSGDSSADMNDQGVKIGDGDNLGLTDVNMAGYGNQGPDGTDKGNEDHNNKDKISQEDTVKDKTNQDGVAKDKADQDNVDDKDKPNQDVDDKDQSDKYANVTGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SRK1</accession>
    <name>A0A433SRK1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_020340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001143">
        <property type="protein sequence ID" value="RUS71902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SRK1"/>
    <dbReference type="OrthoDB" id="10606106at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS71902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="117" mass="12232" checksum="C8E3EA0104C36F8D" modified="2019-05-08" version="1">MTTSCSLPDLKLLKVFSCSPSKMGLSVAPPCKARLTECTTPYVTSAEKMAGVDDELFELKICKTLQAKGCLDQNNNGAVCTAGEIAAIADEVVCDGTSGLLSSVLLLAAMLVLTRVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433ST43</accession>
    <name>A0A433ST43_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_019927</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001082">
        <property type="protein sequence ID" value="RUS72319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433ST43"/>
    <dbReference type="OrthoDB" id="6134317at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS72319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="15985" checksum="CFBBC8C49E185AB9" modified="2019-05-08" version="1">MLDSLEKYHGVDIHTVNSASRRWDRIMAYFECCGVNSYKDFRGLEYWPPTKIRGRTVILQTPIVCCKGPVNDLTCASKGRAHPRNNNMIKGCYNVIFNKFFYNRMTVGLIVLLIMFQSVVLFCCSWILCYMSRRNSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433ST97</accession>
    <name>A0A433ST97_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4709 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_019749</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001061">
        <property type="protein sequence ID" value="RUS72495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433ST97"/>
    <dbReference type="STRING" id="188477.A0A433ST97"/>
    <dbReference type="OrthoDB" id="10027521at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040119">
        <property type="entry name" value="C10orf67-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031651">
        <property type="entry name" value="DUF4709"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22382">
        <property type="entry name" value="RIKEN CDNA 4921504E06 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22382:SF7">
        <property type="entry name" value="RIKEN CDNA 4921504E06 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15821">
        <property type="entry name" value="DUF4709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4709" evidence="2">
        <location>
            <begin position="49"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS72495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="577" mass="66414" checksum="EE76A04395E257F2" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433STZ4</accession>
    <name>A0A433STZ4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_019478</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001022">
        <property type="protein sequence ID" value="RUS72760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433STZ4"/>
    <dbReference type="OrthoDB" id="6132489at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35842">
        <property type="entry name" value="SI:CH211-67E16.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35842:SF1">
        <property type="entry name" value="SI:CH211-67E16.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS72760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="420" mass="47594" checksum="789F2A18D5225BE4" modified="2019-05-08" version="1">MAPKSPYGRYVASLPDTRLSGGGAHDAVLVLDPYPEASWGHVVLVFFIDTKTSRLQCQERRGIYLDKDECMYLAHRDRCHDAPTRKSRRRNFAFKCEINFLPTVHLDMDQTRTKRNHLKCLPGLPGYHTCPKAWSLNHNSLALCDPLSHNSHHCVTTPDTIRSSCRLFEVCDQAVLLSGGWNSVTIGDQAEHRLVRMAQLLKNNGFKRRNIKVFHANGIEQLDTDGGKQPLRVYPSAMKLALRHHIQQMCSTVRCVDSLVLYLNSPTLQGGTMLLWDLNGNGLADEMERYSVEELLSDTANCSANYVQILVDQSYAGEVSHSVKLSRHHDNVIVMASGRGREYSHAGEFTEFWTNMSDFRACTLHLHRLKQIHALHCSSNSTHGIKGRARNLSFEGLYDAFFLCFEAMKLKNAYMGFIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SU06</accession>
    <name>A0A433SU06_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EGW08_019586</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">EC2010</strain>
            <tissue evidence="17">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="RQTK01001039">
        <property type="protein sequence ID" value="RUS72648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SU06"/>
    <dbReference type="STRING" id="188477.A0A433SU06"/>
    <dbReference type="OrthoDB" id="2158884at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07830">
        <property type="entry name" value="STKc_MAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:002261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000071">
        <property type="entry name" value="serine/threonine-protein kinase MAK isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="4"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RUS72648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="221" mass="25864" checksum="DBE6350AD8F13A34" modified="2019-05-08" version="1" fragment="single">MNRYQISKQLGDGTYGSVLLATAVENNEKVAIKKMKKKYYSWDECLSLREVKSLRKLNHPNIVKLKEVIRENDMLYFVFEFMKENLYQMMKDRDKLLPESVVRNIMYQVLQGLSFMHKHGFFHRDLKPENLLCNGTELVKIADFGLARETRSRPPYTDYVSTRWYRAPEVLLRSTNYSSPIDIWAVGCIMAELYTLRPLFPGSSEIDEIFKICSVLGTPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SZE2</accession>
    <name>A0A433SZE2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VCBS repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_017580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000810">
        <property type="protein sequence ID" value="RUS74674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SZE2"/>
    <dbReference type="STRING" id="188477.A0A433SZE2"/>
    <dbReference type="OrthoDB" id="10250728at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024881">
        <property type="entry name" value="Tip"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412:SF0">
        <property type="entry name" value="T-CELL IMMUNOMODULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412">
        <property type="entry name" value="T-CELL IMMUNOMODULATORY PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019133679" description="VCBS repeat-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS74674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="28949" checksum="5FE37E1964A6B82B" modified="2019-05-08" version="1" fragment="single">MLLIQLTILPFMVASVVECSLSDVTPAVFGRENGLIAAFGDINADKATDIFVLSEEGKSLSILQADIDISRDETSFSNKPFILGSDEDRPIVAVVPGDFNVDSQMDVLVMRKADDDKMSTRVNIEIYVGSQDAETNSPYLKINETFRDQPAVIDGNGDMSPDLFGETIGGKRGLWIFKDNDSYSVEFYENPPDYQLPPLKVPQSSAFLDLNGDLTSDLCAVSEISGETNFEFWLNKEGVLTYTYSIKAPPQLKVVGQPVFADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SZH5</accession>
    <name>A0A433SZH5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_017541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000807">
        <property type="protein sequence ID" value="RUS74711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SZH5"/>
    <dbReference type="OrthoDB" id="6081966at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS74711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="608" mass="66203" checksum="8A00AD1DA0FEA0D1" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T065</accession>
    <name>A0A433T065_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_017294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000784">
        <property type="protein sequence ID" value="RUS74939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T065"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS74939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="198" mass="20417" checksum="85E0A92FE24DDE60" modified="2019-05-08" version="1">MTARTNTPPATPRIMGSWANMPALLLLPCSRTSPVCSGSLGRTVELEVPAAASVAKKEVLLSRHLSAREEPIQALCGLPLESTVGDFEVLSILSISKIDASTSKYIPVFVSGLEVSAIDDTGVDGVVGNSVEDKSLAVITKVVVVEDLAVGVVVVVVVLGAVDAVVVVEVVVEVVVVGKVVVGDVVVVDVVVVVVVVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T3B5</accession>
    <name>A0A433T3B5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenosylmethionine decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">EGW08_016212</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">EC2010</strain>
            <tissue evidence="19">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>S-adenosyl-L-methionine + H(+) = S-adenosyl 3-(methylsulfanyl)propylamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:15981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="4.1.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic AdoMetDC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.50" evidence="4"/>
    <dbReference type="EMBL" id="RQTK01000692">
        <property type="protein sequence ID" value="RUS76034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T3B5"/>
    <dbReference type="STRING" id="188477.A0A433T3B5"/>
    <dbReference type="OrthoDB" id="1068353at2759"/>
    <dbReference type="UniPathway" id="UPA00331">
        <property type="reaction ID" value="UER00451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006597">
        <property type="term" value="P:spermine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.90.10">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048283">
        <property type="entry name" value="AdoMetDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001985">
        <property type="entry name" value="S-AdoMet_decarboxylase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018166">
        <property type="entry name" value="S-AdoMet_deCO2ase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00535">
        <property type="entry name" value="SAM_DCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570:SF0">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01536">
        <property type="entry name" value="SAM_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001355">
        <property type="entry name" value="S-AdenosylMet_decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01336">
        <property type="entry name" value="ADOMETDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="12" id="KW-0704">Schiff base</keyword>
    <keyword evidence="8" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5042320851" description="S-adenosylmethionine decarboxylase beta chain" evidence="18">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042320852" description="S-adenosylmethionine decarboxylase alpha chain" evidence="18">
        <location>
            <begin position="68"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="15">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for catalytic activity" evidence="15">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for processing activity" evidence="15">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for processing activity" evidence="15">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autolysis" evidence="17">
        <location>
            <begin position="67"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="16">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001355-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001355-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR001355-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR001355-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RUS76034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="328" mass="37521" checksum="BE383A6D4EA5621E" modified="2019-05-08" version="1">MATAAGSYHYEGTEKLLEVWFASTSNDETCDLRKIRREKWDALLKIVRAEIISMIQDDDMDAYVLSESSMFITKKRFILKTCGTTTLLLAVNHLVQMVKKECGFDKVIDIFYSRKNFAQPELQHHLHQSFDKEVSLLDDMFQNGSAYVLGRMNKDCWYLYTLDDCGVEQPDQTFELLMWDMCPKSMEVFAMKVSQDGKDATKRSGICNIIPGIKIDDTLFDPCGYSMNGILPGGYYITIHVTPEPHCSYVSFESNVPRASYENLIMKVLGVFNPGKFLMTVFANSASIAHGSLKQLEEIDTLEGYSRNDHQFCSFKNYYLTYTQFSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T420</accession>
    <name>A0A433T420_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_015967</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000676">
        <property type="protein sequence ID" value="RUS76274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T420"/>
    <dbReference type="STRING" id="188477.A0A433T420"/>
    <dbReference type="OrthoDB" id="3800937at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051764">
        <property type="term" value="P:actin crosslink formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030838">
        <property type="term" value="P:positive regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013606">
        <property type="entry name" value="I-BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027681">
        <property type="entry name" value="IRSp53/IRTKS/Pinkbar"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14206">
        <property type="entry name" value="BRAIN-SPECIFIC ANGIOGENESIS INHIBITOR 1-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14206:SF7">
        <property type="entry name" value="INSULIN RECEPTOR SUBSTRATE 53 KDA, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08397">
        <property type="entry name" value="IMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="156"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="115"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="373"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="130"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="430"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="458"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="476"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS76274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="490" mass="52829" checksum="2B4EEF90C60BE984" modified="2019-05-08" version="1">MKYQEKLDEFRLQGLKLAMLEERKCYCFVLSHLTAVATVQLHYHDRGLDCLTDDLATWRQLSSQAHVLPRSADAYLRISNPVHMNGGGAIASSGGLGMGYSYNGAEQGINHRSPYRQIPAKGDYHPGRPPSEYSEPSQSPRSQTLQRRPMLPAAPPQGPQVKAVYPHVATHEGQLRFNIGDTMTLVGEPADGWNYAYNPVTDEYGWLPLAYVESAPRQVAHTGPPPRAKSISDLKEHSLNALASTFTFDTTSVAHPYNMPGTARRPKSLHEPAMMKMINDTFGQPSGSETSSMHSSSTVSSQVSQAGYISQARPYPDNSVYQPISGEHGDLQHLHMSQAIYSADGQPLRPPLSSQMMVGGPPSPPLPPPPTTFHSHYNVGHAPSQQAPPLQHEGAISGYSMPNTPLVQNRPRSNSIGTYLPHSTPTPIFSIPPPPSFNAPAPPGTANGGMRQVPPPVSQKTTSVTSMSSQSHGGGAPPPPPPPPPPPPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T4E1</accession>
    <name>A0A433T4E1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_015794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000661">
        <property type="protein sequence ID" value="RUS76453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T4E1"/>
    <dbReference type="OrthoDB" id="10005811at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042847">
        <property type="entry name" value="EFC12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47225">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47225:SF1">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS76453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="236" mass="25449" checksum="6BBD21166ADD80DD" modified="2019-05-08" version="1">MGRISRVSMTSGAASRLSGAGGGGGSDSDGNRNGRGSRGVGFDSKGGGVGGGAASNGKKSVGFRPLDEERSDSGSSKRSYIAVEDTYPFAAQVTPKVYKENLSSGRALITRKIDNWMTFEEYTKYTENLPNRFQHLGRQSNPDAAWPGSLLDKLRLCMDHDLPQVDGQGRPLANRESRVYEGLGTGLYNGRGHAVFRSAAPQSKRAYPGYNNDLLTWPVGENGVRYGSIDEHRVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T581</accession>
    <name>A0A433T581_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_015513</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000640">
        <property type="protein sequence ID" value="RUS76733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T581"/>
    <dbReference type="OrthoDB" id="10529217at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS76733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="177" mass="20018" checksum="BBC063EC95B722D9" modified="2019-05-08" version="1">MNASPAENSRDSTGTNSSQQARGVRASNSAHGRGNRTSSFSPLVTSIVTYFLLLVRDLLTFFVRGGISAMLFAMDQVLRVLLLLMDVVLGPTVSSIVTYPARMVVWLYQILLWVAYTMVELLLYLPRQVLIVYVIVLLLFLVLMPSPVVNFFKHLFTVLHRFIGLYKTVYEMVKEHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T5M4</accession>
    <name>A0A433T5M4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GP152 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_015375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000628">
        <property type="protein sequence ID" value="RUS76865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T5M4"/>
    <dbReference type="STRING" id="188477.A0A433T5M4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF16">
        <property type="entry name" value="GP152 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS76865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="15976" checksum="6C144DF9327E5F8A" modified="2019-05-08" version="1" fragment="single">SIHPSIHPSIHPSIHPSIHPSIHPSIHPSIHPSIHPSIHPSIHPSIHPSIHPSIHPSIHPSIHPSIHPSIHPSIHPSIHPSIHPSIHPSIHPSIHPSIHPSIHPSIHPSIHPSIHPSIHPSIHPSIHPSIHPSYLSIFLQLLFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TBK6</accession>
    <name>A0A433TBK6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_013289</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000480">
        <property type="protein sequence ID" value="RUS78948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TBK6"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS78948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="141" mass="15732" checksum="D2E888273E39E855" modified="2019-05-08" version="1" fragment="single">QPQPQPITSQVQGGRSDIPEGFSSYGEYIANMFANSASGALRYTNKIRGPSSVTAVRRQTDQATAEFEQRFLQEVVGYPSYYARQQQLSTGYSGIPNGIPTWLQQPRRISLDQDALDRLCAACYSSCRFSQCVWSCPQLMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TBP8</accession>
    <name>A0A433TBP8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_013210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000476">
        <property type="protein sequence ID" value="RUS79027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A433TBP8"/>
    <dbReference type="OrthoDB" id="20982at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040031">
        <property type="entry name" value="Codanin-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28678">
        <property type="entry name" value="CODANIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28678:SF1">
        <property type="entry name" value="CODANIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="482"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="510"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS79027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1864" mass="208437" checksum="7C541919D25E41F8" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TCN1</accession>
    <name>A0A433TCN1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_013042</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000465">
        <property type="protein sequence ID" value="RUS79184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TCN1"/>
    <dbReference type="STRING" id="188477.A0A433TCN1"/>
    <dbReference type="OrthoDB" id="6116537at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="189"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="193"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS79184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="359" mass="39488" checksum="557E46B574921EAF" modified="2019-05-08" version="1" fragment="single">RVSVQSKKSYEHSGVQKVPRSTPIKGRLTTSTAESIGKHKVKVILLGDPGVGKSTFLQTLVRGEFHPSSKMSNMMSAQTNLVFTHGGQEVELEIQDTAGQERFRSLTASYYRYAHACLVFFNVHDKESFASVPDWLEDIRTYHSGSNTPPVVLVGLLHRPPKDRVSYRRRSSLRGDHLLSFLASSYGSTARVTSNSSTNNGNSNRNSNSNSNSNSNSNRNRNSNSTSNDRVSGGDQDGPGIQRPQPLQHHSTPQLSLPPPPGTIFEPRMGGGYTREISQEQAEHMADHWEIPYLEVDTRGNQESVLEAVNTLLDLVMSDLASVSRSTMDSIVPGGNRKWSMAGSDASFKAYSYACCIHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TD90</accession>
    <name>A0A433TD90_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycoside hydrolase family 38 central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_012689</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000444">
        <property type="protein sequence ID" value="RUS79559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TD90"/>
    <dbReference type="STRING" id="188477.A0A433TD90"/>
    <dbReference type="OrthoDB" id="10261055at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.50:FF:000003">
        <property type="entry name" value="Alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="entry name" value="Glycoside hydrolase family 38, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050843">
        <property type="entry name" value="Glycosyl_Hydrlase_38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11607">
        <property type="entry name" value="ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11607:SF3">
        <property type="entry name" value="LYSOSOMAL ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="Families 57/38 glycoside transferase middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 38 central" evidence="3">
        <location>
            <begin position="5"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS79559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="206" mass="22327" checksum="72224C54D1D79F92" modified="2019-05-08" version="1">MGEMSAEIILSLAQARARRDHLASFPSRALAGMMEKSRRALALFQHHDGITGTAKDHVVDDYGRRLLGGLHDAKRVVAECANFLLQADRTSYSFDPATGPEFALDETRDNHNSLPEKPVLTLNTGASEPSGGQAVVLYNSLAQPRSEVVSVLTDWPYVEVLGPDARPLHSQVEPLWPSEGEPDGRPRAGVYSVKFVADLTGLAVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TDB6</accession>
    <name>A0A433TDB6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin-conjugating enzyme E2 H</fullName>
            <ecNumber evidence="8">2.3.2.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">(E3-independent) E2 ubiquitin-conjugating enzyme H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">E2 ubiquitin-conjugating enzyme H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Ubiquitin carrier protein H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin-protein ligase H</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">EGW08_012758</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">EC2010</strain>
            <tissue evidence="19">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. E2 ubiquitin conjugating enzyme that transfers ubiquitin to MAEA, a core component of the CTLH E3 ubiquitin-protein ligase complex. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with MAEA and WDR26, components of the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.24" evidence="8"/>
    <dbReference type="EMBL" id="RQTK01000448">
        <property type="protein sequence ID" value="RUS79490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TDB6"/>
    <dbReference type="STRING" id="188477.A0A433TDB6"/>
    <dbReference type="OrthoDB" id="269518at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23797">
        <property type="entry name" value="UBCc_UBE2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000078">
        <property type="entry name" value="ubiquitin-conjugating enzyme E2 H isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="3 17" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="18">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="16">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00076312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00078369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00082119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RUS79490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="142" mass="16003" checksum="49988D20A98D26BE" modified="2019-05-08" version="1" fragment="single">MSSPSPGKRRMDTDVVKLIESKHEVTILGGLNEFTVKFFGPSGTPYEGGVWKVRVDLPDKYPFKSPSIGFMNRVYHPNIDEVSGTVCLDVINQAWTALYDLANIFESFLPQLLTYPNPVDPLNGDAAALYLHKPEEYKKRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TDW1</accession>
    <name>A0A433TDW1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">IMS import disulfide relay-system CHCH-CHCH-like Cx9C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_012463</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000428">
        <property type="protein sequence ID" value="RUS79779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TDW1"/>
    <dbReference type="OrthoDB" id="3821113at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034595">
        <property type="entry name" value="NDUFAF8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34561">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34561:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS79779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="69" mass="7787" checksum="C162FD9F023B9571" modified="2019-05-08" version="1">MNSVKSARQRMLRYPAALSKCSTQLKLGIYFISFQAAAYGKCISTSENLKKSDCQKEFEALRECVKNAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TFY8</accession>
    <name>A0A433TFY8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Urocanate hydratase</fullName>
            <ecNumber evidence="4">4.2.1.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Imidazolonepropionate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EGW08_011744</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">EC2010</strain>
            <tissue evidence="15">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>4-imidazolone-5-propanoate = trans-urocanate + H2O</text>
            <dbReference type="Rhea" id="RHEA:13101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17771"/>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
            <dbReference type="EC" id="4.2.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the urocanase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.49" evidence="4"/>
    <dbReference type="EMBL" id="RQTK01000388">
        <property type="protein sequence ID" value="RUS80493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TFY8"/>
    <dbReference type="STRING" id="188477.A0A433TFY8"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016153">
        <property type="term" value="F:urocanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:L-histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:L-histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1770.10:FF:000002">
        <property type="entry name" value="Urocanate hydratase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1770.10:FF:000003">
        <property type="entry name" value="Urocanate hydratase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10730:FF:000002">
        <property type="entry name" value="Urocanate hydratase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10730">
        <property type="entry name" value="Urocanase like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1770.10">
        <property type="entry name" value="Urocanase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00577">
        <property type="entry name" value="HutU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055351">
        <property type="entry name" value="Urocanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023637">
        <property type="entry name" value="Urocanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035401">
        <property type="entry name" value="Urocanase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038364">
        <property type="entry name" value="Urocanase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023636">
        <property type="entry name" value="Urocanase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035400">
        <property type="entry name" value="Urocanase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035085">
        <property type="entry name" value="Urocanase_Rossmann-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036190">
        <property type="entry name" value="Urocanase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01228">
        <property type="entry name" value="hutU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003820">
        <property type="entry name" value="PRK05414.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12216">
        <property type="entry name" value="UROCANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12216:SF3">
        <property type="entry name" value="UROCANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01175">
        <property type="entry name" value="Urocanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17392">
        <property type="entry name" value="Urocanase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17391">
        <property type="entry name" value="Urocanase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001423">
        <property type="entry name" value="Urocanate_hydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111326">
        <property type="entry name" value="Urocanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01233">
        <property type="entry name" value="UROCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urocanase N-terminal" evidence="13">
        <location>
            <begin position="96"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Urocanase Rossmann-like" evidence="12">
        <location>
            <begin position="225"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Urocanase C-terminal" evidence="14">
        <location>
            <begin position="452"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RUS80493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="690" mass="76081" checksum="8561DEE913A6B4A3" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TGX3</accession>
    <name>A0A433TGX3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_011424</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000372">
        <property type="protein sequence ID" value="RUS80803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TGX3"/>
    <dbReference type="STRING" id="188477.A0A433TGX3"/>
    <dbReference type="OrthoDB" id="552049at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052763">
        <property type="entry name" value="DnaJ_C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44825">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44825:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="112"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS80803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="331" mass="38254" checksum="4E35F185AFB0E824" modified="2019-05-08" version="1">MTISVAKEIKRINKFWRTVSFNAPFKNASIRTSFDKVDLSTIKLKYKLGCTCSNSVPSSRLSSGYGFSCSKPLLYQHAMCIGRIRVKASISEARALNITFNRLASTFVKNATHYEVLNISRSASTDEVRQAFISLSKKWHPDKNPKDPTRHQKFVQINEAYSTLSKPLARRDYDLTLDAQKYVSRQMNASTSHTYGYGYSPHAGPYYHHREHVYDEYYWAGEAHGTQRARFTSLMNFYMLIVCATFATVSIILHYMYRLPDPKHHHLRKNLSLEEVEKHDLIMQSEQDGVTLYYYSIPKKDSKKFDIVVLRKSLDSTSEEPKMQEVTRSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TIC8</accession>
    <name>A0A433TIC8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SLC41A/MgtE integral membrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_010970</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC41A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000347">
        <property type="protein sequence ID" value="RUS81266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TIC8"/>
    <dbReference type="STRING" id="188477.A0A433TIC8"/>
    <dbReference type="OrthoDB" id="5791097at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.20:FF:000001">
        <property type="entry name" value="Solute carrier family 41 member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="entry name" value="SLC41 divalent cation transporters, integral membrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045349">
        <property type="entry name" value="SLC41A1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228">
        <property type="entry name" value="DIVALENT CATION TRANSPORTER SOLUTE CARRIER FAMILY 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228:SF7">
        <property type="entry name" value="SLC41A_MGTE INTEGRAL MEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="MgtE membrane domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="511"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="548"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="11">
        <location>
            <begin position="207"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="11">
        <location>
            <begin position="419"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS81266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="580" mass="62263" checksum="0FBB51BFBE588148" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TJC2</accession>
    <name>A0A433TJC2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_010544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000324">
        <property type="protein sequence ID" value="RUS81682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TJC2"/>
    <dbReference type="STRING" id="188477.A0A433TJC2"/>
    <dbReference type="OrthoDB" id="329272at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905502">
        <property type="term" value="F:acetyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039840">
        <property type="entry name" value="NAA80"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13538">
        <property type="entry name" value="N-ACETYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13538:SF4">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS81682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="156" mass="17655" checksum="3FD527060FAB8806" modified="2019-05-08" version="1">MSEDFQVLPVHQHIHLQDECSEILNQQWPRSKAARNHSINKSTDTLPVSLAFVRHFENKADEVLGFSKISAVQGIKDAGLIESVVLREDNRGKGLGRVLMNLTEQYGHKLGIRRMYLSTKDKEGFYAHLGYEKCQPVLSLGNNAHRVPESMENIAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TPG6</accession>
    <name>A0A433TPG6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_008773</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000242">
        <property type="protein sequence ID" value="RUS83457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TPG6"/>
    <dbReference type="STRING" id="188477.A0A433TPG6"/>
    <dbReference type="OrthoDB" id="8918594at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF54">
        <property type="entry name" value="PROTEIN ESCARGOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="19"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS83457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="303" mass="34573" checksum="B7EEA6117D954085" modified="2019-05-08" version="1">MPKLLQLLSMRDKKELPEEQCMHKEVSDLDKRVSINGSKKLPASISSASEPSTNPKLNSRRGRQIEKGIYNEEVVNAKNQGPSLVCPHCDKVYRTLAGYERHRARLKAHTSSATQGDFSEDLGHWIDLSTWRCSRCSKTFTGAAKIHHHIRLHCRVCPYVARSKTNIARHVRTHSQDRIFQCPLCDYKAVLKFSVTQHMLTHTKERPFPCNQCDYSARTSSQLASHKLRHSAGQQCYICGPTEESRRCRPNQPMNVPENITIDDTMCTVIENTAYHLDTLCKDYPGPNGYYFECVDKSNSEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TS37</accession>
    <name>A0A433TS37_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_007899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000208">
        <property type="protein sequence ID" value="RUS84367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TS37"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS84367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="120" mass="14040" checksum="5A97CB5CEBE1B707" modified="2019-05-08" version="1" fragment="single">VFCLVCFLSGVFSDWCVFWLVCFLTGVFSDWCVFCLVCFLFSIWCVFCLVCFMTGVFFAWCVFCLVCFLYGVFSVWCVFYLVCFLFSIWCVFCLVCSLSSCLMCFLSGVFSVWHVFCLQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TUP3</accession>
    <name>A0A433TUP3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_006932</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000175">
        <property type="protein sequence ID" value="RUS85285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TUP3"/>
    <dbReference type="STRING" id="188477.A0A433TUP3"/>
    <dbReference type="OrthoDB" id="6144753at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050971">
        <property type="entry name" value="Cadherin-domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025">
        <property type="entry name" value="DESMOGLEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025:SF23">
        <property type="entry name" value="NEURAL-CADHERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="71"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="283"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="332"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS85285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="407" mass="43814" checksum="8026FB6A878908D9" modified="2019-05-08" version="1" fragment="single">FSIDGNTGDITLTSSLDFSEKPEHVITVTASDGDLESTGVVTIQVVPINNKPPVILTSASDLNASISRRTGTLVADIDAKDDDAGGTVLSYSLLTHSNLFAIDNQGRITVTGSEDDLTQDVYQVAVIVQDDGVPRYSTAAAVTVNFPKLEAPVVAAQMEKSDSILPLILGAVAAVLLIVIIILIVYICKRRSRDKEHLDRAKKQQPSHDAKALAFKKQGTLGKQARVNIEFGEEPSDGDTTVQENPLSRASKGGYYNFGQVYSDTDTEVDMNEIQVETSVSPYVNVPASNDDNNNDNIYNHSQMSEESEDYAPSDKQAITSFFRNGTLGTYQDSSDSELSLNASPTDSQDSKKNLVVASALARSRLPEEDLANGIHAVSSDSDTITNLDPDSSVVPASQKQELTVYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TUT0</accession>
    <name>A0A433TUT0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_006879</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000173">
        <property type="protein sequence ID" value="RUS85336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TUT0"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="599"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS85336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="638" mass="67790" checksum="AC5114BE64F6F89B" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TVR5</accession>
    <name>A0A433TVR5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_006547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000162">
        <property type="protein sequence ID" value="RUS85671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TVR5"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS85671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="216" mass="24715" checksum="4A7AE4E8CEF06F8A" modified="2019-05-08" version="1">MGGLETDNFQGIAWNILVAVKKTNGFVQYETNPAVQLYKSAVQWSVVHQVQWSVVHQVQLSVVHQVQWSVVHQVQWSVVHQVQWSVVHQVQWSVVHQVQWSVVHQVQWSVVHQVQVVLTQWSVVHQVQWSVVHQVQVVLTPAAVCVELRHVLQREARLAPALVRGDNVLGEAQWVFVVDQQGRKDNSCRLKHGTVRVAAAQVIKITTTRGIHFYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TX74</accession>
    <name>A0A433TX74_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FK506-binding protein</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_006147</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="RQTK01000150">
        <property type="protein sequence ID" value="RUS86127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TX74"/>
    <dbReference type="STRING" id="188477.A0A433TX74"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.340">
        <property type="entry name" value="Nucleoplasmin core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041232">
        <property type="entry name" value="NPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036824">
        <property type="entry name" value="Nucleoplasmin_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023566">
        <property type="entry name" value="PPIase_Fpr3/Fpr4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811:SF19">
        <property type="entry name" value="39 KDA FK506-BINDING NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811">
        <property type="entry name" value="FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17800">
        <property type="entry name" value="NPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001473">
        <property type="entry name" value="FK506-bp_FPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69203">
        <property type="entry name" value="Nucleoplasmin-like core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="328"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="110"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="280"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS86127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="415" mass="45695" checksum="9E48E1196AB8D607" modified="2019-05-08" version="1">MVKIQECSDNMFWGVTIDSGKKYSQTVKQAFHVSMAALDLNGRKNSENVQVMVQHDSSEFLLCTLNDKVLQQSLDLNFETGEEVAFSLNGSGVVHLTGYLALDVDDLEDESFSDSDEGIQHNSAQFDSKKRKNESAGQTPKKVKLSTSDMLDDVDSNDDEDDEDVSVALNYLEVEQYSEDDDEDIDDEEEDDIDSDEVDEVLNSTAEKKKTPKLEKSVQKAKGDENKNTPKKQAKAKDAKTPQQSTPAQNKSESEQPVTPENGESASKKKRKRKKKNKGDNSMVSFESDANTPAQTPKTETTPKKKVVAGGTIVEDIKVGHGPEAKPGKMVSVYYVGTLAKNQKRFDSCQGGKPFRFRLNQGEVIKGWDNGVNGMKVGGKRKITVPANQGYGNVKQGPIPPNSTLVFEVELKAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TYE6</accession>
    <name>A0A433TYE6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_005656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000134">
        <property type="protein sequence ID" value="RUS86575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TYE6"/>
    <dbReference type="OrthoDB" id="10022113at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35836">
        <property type="entry name" value="VCBS REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35836:SF1">
        <property type="entry name" value="VCBS REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019066042" evidence="1">
        <location>
            <begin position="22"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS86575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="253" mass="27749" checksum="D8B089096F6FBCEE" modified="2019-05-08" version="1" fragment="single">MLVSTVARTLVLIGMTMQVASVIRPTLLGKIPFRSPGFINLIEVTSSSGQKYNLVISSSQPYNQVGLVKDIGSLLNSVNTISPDVINTGLLAPNLISGVPDSALGASEPYIAIPSGFLDPDRRDGTITLQPLRDGAETVLTQPNQEWFYSKVQWVDMNKDGFLDVVTSESHSRSFGEIDGELVYLTNPQSGRLTNQWAEMFIGNGPDMFFTHTTVQVALALKEVIITADFYNAKLQVFWTESLTDDWSDQTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TYZ5</accession>
    <name>A0A433TYZ5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_005493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000129">
        <property type="protein sequence ID" value="RUS86770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TYZ5"/>
    <dbReference type="STRING" id="188477.A0A433TYZ5"/>
    <dbReference type="OrthoDB" id="18431at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000003">
        <property type="entry name" value="Brefeldin A-inhibited guanine nucleotide-exchange protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF375">
        <property type="entry name" value="LD29171P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS86770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="131" mass="15063" checksum="C612C18FE9D6B939" modified="2019-05-08" version="1" fragment="single">MYAYIDHMNFVDMDIVSALRKFLSGFRLPGESQKIDRLMEKFASRYYECNQQLEIFASADTAYVLAFSVIMLTTDLHNPQVKANHKMTKEQYIRMNRGINDSKDLPPDYLSAIYDEISGKEIKMKASSGGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U1Z5</accession>
    <name>A0A433U1Z5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_004375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000099">
        <property type="protein sequence ID" value="RUS87842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U1Z5"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="584"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="668"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="781"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="884"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="91"/>
            <end position="105"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="222"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="315"/>
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            <end position="329"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="701"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="884"/>
            <end position="901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS87842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="945" mass="105341" checksum="C530A562C078922A" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U459</accession>
    <name>A0A433U459_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_003678</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="RUS88578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="379"/>
        </location>
    </feature>
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        <location>
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    </feature>
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        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
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        <location>
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        </location>
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        <location>
            <begin position="482"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS88578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U4M9</accession>
    <name>A0A433U4M9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_003471</name>
    </gene>
    <organism evidence="1 2">
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        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
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                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
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                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS88754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="150" mass="16594" checksum="1435EA70378BD046" modified="2019-05-08" version="1">MCLASSVRANVMEICEACSVRANLMDIYEASSVRANLMDIYEASSVRANLMDICEASSVRANLMDIYEASSVRANLMDICEASSVRPNLMDIYEATSVRANLMDICETSSVRAYPMDIYETSSVKANLMYIYETSSVRVNLMDICEASSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U5M7</accession>
    <name>A0A433U5M7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_003135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000065">
        <property type="protein sequence ID" value="RUS89127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A433U5M7"/>
    <dbReference type="OrthoDB" id="6089439at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052145">
        <property type="entry name" value="Mediator/Homeobox_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24330">
        <property type="entry name" value="HOMEOBOX PROTEIN BARH-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24330:SF19">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
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            <begin position="1239"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="12"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
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            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1080"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1620"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1644"/>
            <end position="1657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS89127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1664" mass="182030" checksum="7DA424A07462191B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U6Z0</accession>
    <name>A0A433U6Z0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_002695</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000052">
        <property type="protein sequence ID" value="RUS89577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U6Z0"/>
    <dbReference type="STRING" id="188477.A0A433U6Z0"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030665">
        <property type="term" value="C:clathrin-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031984">
        <property type="term" value="C:organelle subcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09258">
        <property type="entry name" value="AP-1_Mu1A_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14835">
        <property type="entry name" value="AP1_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1170:FF:000002">
        <property type="entry name" value="AP-1 complex subunit mu-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000006">
        <property type="entry name" value="AP-1 complex subunit mu-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="12">
        <location>
            <begin position="152"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00057121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS89577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="407" mass="46965" checksum="6E114078A8B37074" modified="2019-05-08" version="1">MISRNYRGDIDMSAIDKFMTLVMEKEEDSNLTPIIIHGDVAFMYIKYNNLYLVATSKKNANVTLVFSFLHKLVQIFVEYFKELEEESIRDNFVIIYELLDEVMDFGYPQTTDSKILQEYITQEGQKLEIAPRPPPAVTNAVSWRTDSVKYRKNEVFLDVIESVNLMVSANGNVLRSEIVGSVKMRVFLSGMPELRLGLNDKVLFESTGRGKSKSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWVESVIERHAHSRVEYMIKAKSQFKRRSTANNVEIIIPVPNDADSPKFKTTVGSCKYVPEVNCVVWTIKSFPGGKEYLMRAHFGLPSVQNEEMEGKPPINVKFEIPYFTVSGIQVRYLKIIEKSGYQALPWVRYITQNGDYQLRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U7L0</accession>
    <name>A0A433U7L0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_002442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000047">
        <property type="protein sequence ID" value="RUS89830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U7L0"/>
    <dbReference type="STRING" id="188477.A0A433U7L0"/>
    <dbReference type="OrthoDB" id="190835at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032589">
        <property type="term" value="C:neuron projection membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF36">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 9, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="43"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="152"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS89830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="306" mass="34202" checksum="B9D68E5CC36559EB" modified="2019-05-08" version="1">MTVDLQVLPIFVVITAVLALIPFVAMGEPNFDPYHPRKNPHLPYFLPTPHNVTFIKGQEAILQCAVENRGTKTVVWRKEPQSNPLTIGKTRFVADQRFRIENLEHSLSWNLHIRDVKASDSGIYECQVVAKKRKIRQHIELNVDVSSEAIKPKITINGTLFMEKGQTLRLVCNATGSRYPPDAIDWFKDGSKIKSNGRVALTSDVSLAESTISSILSVRRAMLEDAGTYVCRTSDLQVTSARVNILNTDTNNEKRESSGVTSIGSGTYEVQRSEQDPHNSKRPLHPNTVLVGFIVTLLLLKCRIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U8U4</accession>
    <name>A0A433U8U4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_002010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000037">
        <property type="protein sequence ID" value="RUS90229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U8U4"/>
    <dbReference type="STRING" id="188477.A0A433U8U4"/>
    <dbReference type="OrthoDB" id="6415470at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010487">
        <property type="entry name" value="NGRN/Rrg9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475:SF3">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06413">
        <property type="entry name" value="Neugrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS90229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="403" mass="46302" checksum="EF888AA736E9CB03" modified="2019-05-08" version="1">MSLFPRFFNSCKGALSRSFKLAPYEINQSLLFASTVCHVNLCHSKSIKTQDKSGLQVIKVIKPKRVTSQQKKTSRLSSLRSKDEKRHSEINQLPGFHDEEFEFFEDRLASTISQYSSNITAYNAESKFTQSLVKEQAAVKRQTIKKRHFKTAPSPNLLTWAAKEQMRFLHRSNPEDWTIDSLTEHFPVSEESLKRILKTNRGILQEKDILKHDKEVLENWNNLHSKVESGQVSEEDFESFFKCFFNSQNECLVTNAVCQPNLPRPEPAKQQKKKGPLSEIVGDCLLLQEKETDIILKELIPSVSHSLSSKLEETALLFQKIALSFKRTNRNNSMSSLPNVSVNERKQNQSVDTLNNRSPDISEDLYGRNKSRNVRKHKPSLSGTYISNKTIYDENGEFLYKIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UCE0</accession>
    <name>A0A433UCE0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fucosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EGW08_000742</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">EC2010</strain>
            <tissue evidence="16">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Golgi apparatus</location>
            <location evidence="12">Golgi stack membrane</location>
            <topology evidence="12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="RQTK01000010">
        <property type="protein sequence ID" value="RUS91521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UCE0"/>
    <dbReference type="OrthoDB" id="427096at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008417">
        <property type="term" value="F:fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11660:FF:000002">
        <property type="entry name" value="Alpha-(1,3)-fucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438:SF1">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="15">
        <location>
            <begin position="245"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="14">
        <location>
            <begin position="336"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="125"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RUS91521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="534" mass="60946" checksum="5F04F3E074E2B0F1" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z7F3</accession>
    <name>A0A3S0Z7F3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_019843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001072">
        <property type="protein sequence ID" value="RUS72406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z7F3"/>
    <dbReference type="STRING" id="188477.A0A3S0Z7F3"/>
    <dbReference type="OrthoDB" id="6162310at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS72406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="208" mass="23388" checksum="43352DFFE49081C7" modified="2019-04-10" version="1" fragment="single">GWSQNSIGYIDVGWSHHCIGYIDVGWSRHSIGYIDVGWSQHSIGYIDAGWSHHCIGYIDVEWSRHSIGYIDVGWSRHSIGYIGVGWSQNSIGYIDVGWSQHSIGIIDVGWSQHSIGYIDVGWSQNSIGYNDVGWSHHCIGYIDVGWSHHCIGYIDVGWSHHSIGYIDVGWSRHSIGYIDVGWSRHSIGYIDVGWSQHSIGYIDVGRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z7R2</accession>
    <name>A0A3S0Z7R2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TEPP protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_020937</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001237">
        <property type="protein sequence ID" value="RUS71294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z7R2"/>
    <dbReference type="OrthoDB" id="9970246at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034584">
        <property type="entry name" value="SPMIP8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35348">
        <property type="entry name" value="TESTIS, PROSTATE AND PLACENTA-EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35348:SF1">
        <property type="entry name" value="TESTIS, PROSTATE AND PLACENTA-EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22574">
        <property type="entry name" value="SPMIP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS71294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="24301" checksum="9D6A045C2BFBBF27" modified="2019-04-10" version="1">MTTVGVDAARPARVDSLRVPSYAYHYPSFKRVQLAAVKHGMFHPDVPRLRRMDMDNAIHKLSDEHCRNTTSCGPRDFSNATSTPFMPPARRLHSFDITETGKQMHRQYTTPQELTRARKEWSDFLNKSPERYDIKLPELCGSAKDIHFDGYAVRYLRPDVTKSWKYTLQQEPKLDEFAQKPMPANVYARYRDTYPQYHRNVASEMWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZCQ5</accession>
    <name>A0A3S0ZCQ5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">W2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_016343</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BZW family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000703">
        <property type="protein sequence ID" value="RUS75884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZCQ5"/>
    <dbReference type="STRING" id="188477.A0A3S0ZCQ5"/>
    <dbReference type="OrthoDB" id="1727522at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11560">
        <property type="entry name" value="W2_eIF5C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000006">
        <property type="entry name" value="Basic leucine zipper and W2 domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051245">
        <property type="entry name" value="eIF5-mimic_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057397">
        <property type="entry name" value="HEAT_5MP1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043510">
        <property type="entry name" value="W2_5MP1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14208">
        <property type="entry name" value="BASIC LEUCINE ZIPPER AND W2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14208:SF2">
        <property type="entry name" value="PROTEIN KRASAVIETZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25504">
        <property type="entry name" value="HEAT_5MP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="3">
        <location>
            <begin position="252"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS75884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="414" mass="47768" checksum="6FF88D03B8AFCF14" modified="2019-04-10" version="1" fragment="single">MSQKAEKPTLSGTRLKTRKRDEKEKYDPTAFRDSIIAGLSTCGGDLEQVSRYLDKEGSKLDYRRYAEVLFDTLFAGGILAPGGFITESADTGKPARSDICVFRWSGELDQLKGFYHEVFYKLIRRYKYLERAFEDDLKKILLFQKGFSEEEREKLAKITGIILANGLCTPRILSSLFEDHLVKEGISLDFAAHMFSTWLKEKDINSICFALKKHQLDSRLMEMFPLNKRNLEHFTTFFRERNLPIIADMQTAQVASKAKKEAVKYLADMIKDESSDADMTDYVTELIDKQGMSETEVTLSIWTSVMASVEWNKKEDLVAEQALKHLRQFCPLLKATARSPKAELALMLKVQEFCYENMNFLKSFQKIIMLLYQSDVVTEDVILKWYKDGHSAKGKSVFLEQMKKFVEWLHSAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZKL2</accession>
    <name>A0A3S0ZKL2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_012345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000422">
        <property type="protein sequence ID" value="RUS79907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZKL2"/>
    <dbReference type="OrthoDB" id="6152995at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS79907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="546" mass="61564" checksum="A6B15C745E2BCF85" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZMI7</accession>
    <name>A0A3S0ZMI7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SMB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_009724</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000283">
        <property type="protein sequence ID" value="RUS82510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZMI7"/>
    <dbReference type="STRING" id="188477.A0A3S0ZMI7"/>
    <dbReference type="OrthoDB" id="6155123at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036024">
        <property type="entry name" value="Somatomedin_B-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001212">
        <property type="entry name" value="Somatomedin_B_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01033">
        <property type="entry name" value="Somatomedin_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90188">
        <property type="entry name" value="Somatomedin B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50958">
        <property type="entry name" value="SMB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1157"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="domain" description="SMB" evidence="4">
        <location>
            <begin position="536"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="483"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="485"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS82510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1176" mass="131050" checksum="9E80932309AE1AE0" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZNP1</accession>
    <name>A0A3S0ZNP1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_008952</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000250">
        <property type="protein sequence ID" value="RUS83272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZNP1"/>
    <dbReference type="STRING" id="188477.A0A3S0ZNP1"/>
    <dbReference type="OrthoDB" id="9992988at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060340">
        <property type="term" value="P:positive regulation of type I interferon-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19756">
        <property type="entry name" value="Bbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF299">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="91"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="181"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="426"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="469"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS83272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="636" mass="70135" checksum="7E121E1FF492A5FA" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZSP2</accession>
    <name>A0A3S0ZSP2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_007353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000190">
        <property type="protein sequence ID" value="RUS84884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZSP2"/>
    <dbReference type="OrthoDB" id="6152155at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS84884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="146" mass="17116" checksum="89B95436FAC22878" modified="2019-04-10" version="1" fragment="single">DPRPTLLSESRVLKWFDFHRDVGNFSALHCRLMGKDLKNLRQLRDQFPGRVKVVRYEHGATDPQGYAEELYKFLGLQITQDLFDFVKYLTSPVAEKIKQPQVNSTQYRHIKRRAKRDIAIDVNDTNQSLWIQNVSRPNIDKTKSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZTE9</accession>
    <name>A0A3S0ZTE9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Hexosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_017386</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Golgi apparatus membrane</location>
            <topology evidence="1 11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="RQTK01000793">
        <property type="protein sequence ID" value="RUS74862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZTE9"/>
    <dbReference type="STRING" id="188477.A0A3S0ZTE9"/>
    <dbReference type="OrthoDB" id="5512589at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000001">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF314">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS74862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="367" mass="41047" checksum="365CA9D62D219BA5" modified="2019-04-10" version="1">MNRSYAALLGLLLVAVFFVNLFIYKYVFGLGLSKAGDEDFDFSHNLSQTSLRPDVLRAAIWPAVSCAGRDVELVLCVPVKRNGFDRRAAVRITWGSYGKYGGRSTEGNGTASRNNHSSLVIQTKNGTFTPGEIILVFFIGSADSLSDENGEQKRIEREAKTYGDIFQDTYIDTYKNLTLKSISIINWISKNCPNARYAAKIDDDMYVNIPYLLSRLRDHAKKTSAAFSSPPENILRAPPPFLVGAINYGASVIRNKKNKWYTSKEAYQDELYPNYLSGTAYAMSGSAAPLLYEASLRIPLFWMEDIFITGMCAKVARVQLIPDAGFNFFKIKPEGCSFRTTISGHRYTIAQLKSIHKELHDPSLKCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZWP4</accession>
    <name>A0A3S0ZWP4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_015084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000606">
        <property type="protein sequence ID" value="RUS77149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZWP4"/>
    <dbReference type="STRING" id="188477.A0A3S0ZWP4"/>
    <dbReference type="OrthoDB" id="6250593at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS77149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="36886" checksum="92683E01B55C6EE7" modified="2019-04-10" version="1">MDSKCCNKFCYASLSHPSIKDAIALHNFSILKLSVLVSEFAQQMAVAHEAFSKEIQTIIASFRRRNYDLKKQRPTETPNCIFNTWEALLQETEMDAQAHLDAASLLHKNVYLPLQEVASHKNRQADMLALFRDNLDSVYVESLREEQKVEKEYHSAFQNFVCLPKDPGEKEGEAVRGRLHRSHNDYILNIRATNKMADEYNKALPRILEAVGQDNTTLTFARPHQDFKPAVALAADDQKNLCRQIILDRLTEESVLRKRSSLQAKAMEMAVSLKHNQDIISTLSNVCQSTNLFMRQEPKKMRTIGYSDVFPNYNHVRIRSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZWS3</accession>
    <name>A0A3S0ZWS3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_004294</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000096">
        <property type="protein sequence ID" value="RUS87939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZWS3"/>
    <dbReference type="STRING" id="188477.A0A3S0ZWS3"/>
    <dbReference type="OrthoDB" id="1305878at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035102">
        <property type="term" value="C:PRC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032443">
        <property type="entry name" value="RAWUL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10825:SF29">
        <property type="entry name" value="POLYCOMB GROUP RING FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10825">
        <property type="entry name" value="RING FINGER DOMAIN-CONTAINING, POLYCOMB GROUP COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16207">
        <property type="entry name" value="RAWUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="18"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="193"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="297"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="612"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="821"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="866"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="961"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1023"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1113"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1162"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="193"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="313"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="621"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="905"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1023"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1117"/>
            <end position="1140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS87939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1185" mass="128201" checksum="43F845E17101A97B" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A1V8</accession>
    <name>A0A3S1A1V8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">serine C-palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">EGW08_011697</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">EC2010</strain>
            <tissue evidence="22">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-serine + hexadecanoyl-CoA + H(+) = 3-oxosphinganine + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:14761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:58299"/>
            <dbReference type="EC" id="2.3.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 18">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="7"/>
    <dbReference type="EMBL" id="RQTK01000385">
        <property type="protein sequence ID" value="RUS80557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A1V8"/>
    <dbReference type="STRING" id="188477.A0A3S1A1V8"/>
    <dbReference type="OrthoDB" id="65434at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017059">
        <property type="term" value="C:serine palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000047">
        <property type="entry name" value="serine palmitoyltransferase 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF3">
        <property type="entry name" value="LD36009P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 18" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="21">
        <location>
            <begin position="164"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="RUS80557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="551" mass="61545" checksum="723CAAEDC41B0F68" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A2Q2</accession>
    <name>A0A3S1A2Q2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heme-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_011089</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000353">
        <property type="protein sequence ID" value="RUS81148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A2Q2"/>
    <dbReference type="STRING" id="188477.A0A3S1A2Q2"/>
    <dbReference type="OrthoDB" id="6424451at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.80.10:FF:000002">
        <property type="entry name" value="Heme-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="entry name" value="Regulatory factor, effector binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006917">
        <property type="entry name" value="SOUL_heme-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220:SF1">
        <property type="entry name" value="HEME-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220">
        <property type="entry name" value="HEME-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04832">
        <property type="entry name" value="SOUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="Probable bacterial effector-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018594924" description="Heme-binding protein 2" evidence="2">
        <location>
            <begin position="31"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS81148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="26735" checksum="841126C41FF53559" modified="2019-04-10" version="1">MYGLRKGHATVLSTTKLVVLVLLYSSVASSLPNSHPLYFKNSRIDVDEVKTALTEKPDFCHNLECPEYKEINKTKDYEEREYVPTKWISTHLEGVDYSEAIRTMFLKLFDYIDGKNSRNEKIAMTAPVLNRVIPGAGPACKSNFTMFFYLSPSVTNPPEPNDKTVVLTSLPGQRVFTRYFGGFAKESDYVKNAEALGNALLKDSKNFDSSFFYTAGYDSPFKILFRHNEVWYVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A3J9</accession>
    <name>A0A3S1A3J9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Myosin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_010368</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000317">
        <property type="protein sequence ID" value="RUS81845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A3J9"/>
    <dbReference type="STRING" id="188477.A0A3S1A3J9"/>
    <dbReference type="OrthoDB" id="10055605at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.360:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000101">
        <property type="entry name" value="Slow myosin heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.360">
        <property type="entry name" value="Myosin S1 fragment, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008989">
        <property type="entry name" value="Myosin_S1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF857">
        <property type="entry name" value="MYOSIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02736">
        <property type="entry name" value="Myosin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 9" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="11">
        <location>
            <begin position="30"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="10">
        <location>
            <begin position="84"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="177"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS81845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="30174" checksum="758A879CFD2C6FFC" modified="2019-04-10" version="1" fragment="single">MSGLDVNDPDFQFLVVDRKKLMKEQTQTFDGKKSCWIPDAKEGFLAAEIQSSKGEEITVKTTEKNETRTVKKDDVQQMNPPKYEKIDDMANMTYLNEASVLYNLKSRYGSGLIYTYSGLFCVAVNPYRRLPIYTQKIINAYRGKRKAEMPPHLFSISDNAYQNMLQDRENQSMLITGESGAGKTENTKKVIMYFANVAAGQQKKTDEPDSKKKEGTLEDQIVQTNPVLEAYGNAKTTRNNNSSRFGKFIRIHFGPQGKIAGADIETC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A4V4</accession>
    <name>A0A3S1A4V4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_009465</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000272">
        <property type="protein sequence ID" value="RUS82765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A4V4"/>
    <dbReference type="STRING" id="188477.A0A3S1A4V4"/>
    <dbReference type="OrthoDB" id="636685at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22929">
        <property type="entry name" value="HFD_POLE4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF79">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="3">
        <location>
            <begin position="64"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS82765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="145" mass="16481" checksum="2923282175C26788" modified="2019-04-10" version="1">MAGSEASQDLVDLEVGLEIEKDNYVELEESEPVTLINQYKQIGDLETVQDEIRSESEPQEKLFKLPLSRIRGIMKTDPDVKIASQDAVIILAKAAELFIQSISRDAAERTLRDKKKTVLRKHLDDVLDTKDRYAFLEGVIESFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A5P7</accession>
    <name>A0A3S1A5P7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_008833</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000244">
        <property type="protein sequence ID" value="RUS83412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A5P7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS83412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="268" mass="29403" checksum="6F35F97E950E0539" modified="2019-04-10" version="1">MVQEEEDKVEILWSLASTVGTDSSVLVQEEEDKVEILWSLASTVGTESSVMVQEEEDKVEILWSLASTVGTESSVMVQEEEDKVEILWSLGSTVGTESSVMVQEEEDKVEILCSLGSTVGTESSVLVQEEEDKVEILCSLESTVGTESSVMVQEEEDKVEILWSLGSTVGTDSSVMVQEEEDKVEILWSLGSTVGTESSVMVQEEEDKVEILWSLGSTVGTESSVMVQEEEDKVEILWSLNSHMLHALMNQQGPGLNKVVLIGRSAWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1ACP3</accession>
    <name>A0A3S1ACP3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_003799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000082">
        <property type="protein sequence ID" value="RUS88462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1ACP3"/>
    <dbReference type="OrthoDB" id="10551885at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="566"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="601"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="648"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="672"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS88462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="716" mass="77605" checksum="6269CF1DDE492EB9" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AEA5</accession>
    <name>A0A3S1AEA5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_002628</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000051">
        <property type="protein sequence ID" value="RUS89610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AEA5"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS89610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="122" mass="13061" checksum="A8CC48B5EDBAA056" modified="2019-04-10" version="1" fragment="single">YMGQCHGATVTSFHVMMGQCHGATVTSFHVMMGQCHGATVTSFYVMMGQCHGATVTSFHVMMGQCHGATITSFHVMIGQCHGATVTFFHVMMGQCHGATITSFHVMMGQCHGATVTSFHVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AS91</accession>
    <name>A0A3S1AS91_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_021577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001359">
        <property type="protein sequence ID" value="RUS70656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AS91"/>
    <dbReference type="OrthoDB" id="6155034at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22966">
        <property type="entry name" value="DD_DYDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007858">
        <property type="entry name" value="Dpy-30_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049630">
        <property type="entry name" value="DYDC-like_DD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05186">
        <property type="entry name" value="Dpy-30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS70656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="152" mass="16734" checksum="58753502F94615A5" modified="2019-04-10" version="1">MTPLLNDLDYLAELTTCLTHALARLVQLRPSDPITFLETSLRQHRRLHPRENQGREVCSPSQSINNSAVASPTPPPAGFAPPSLAREGVTAGKGDALRDTTVNPVALVRCEEDFIADEYINLDSVDPSQVLHKHSRLDFQTIGDLFDDDDFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AVW8</accession>
    <name>A0A3S1AVW8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_022523</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001597">
        <property type="protein sequence ID" value="RUS69716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AVW8"/>
    <dbReference type="STRING" id="188477.A0A3S1AVW8"/>
    <dbReference type="OrthoDB" id="6146969at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="15"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS69716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="335" mass="36842" checksum="97D0182BAEB4361C" modified="2019-04-10" version="1">MAILCQALSVFGVFANIINIVVFCKQGFQDAMTVTLTGLAVADLGIATCAVWLSICYNPLFQQLELPFLPLQIVYLTAGLPRLSCSRVSSWVLALATFERCLCIAMPFKVREIITPGRSLAFVIGVFITMTASVAPIYYTSRTAQKFDEAANRSYLVLSFTEDREKVDAIAFGIGVTFSVCSFVAVAICTAVLVYSLKKTSKWRDSNTSTAQVKKRGAKEISSKNKRASKMVSLISTIFIVCYLPNTINQLVMSLVPDYAKNGRYINTNQVFWSVGFVAESFNCSVNIFMYYTMSTKFRSTLQSMGCGRCLSPGTAGKSAMDDEDGSQKVKKVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AWD4</accession>
    <name>A0A3S1AWD4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_022174</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001500">
        <property type="protein sequence ID" value="RUS70059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AWD4"/>
    <dbReference type="STRING" id="188477.A0A3S1AWD4"/>
    <dbReference type="OrthoDB" id="424753at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000114">
        <property type="entry name" value="Calpain a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022682">
        <property type="entry name" value="Calpain_domain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF379">
        <property type="entry name" value="CALPAIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01067">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="8">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="253"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS70059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="399" mass="46236" checksum="976D70AA41D31F26" modified="2019-04-10" version="1">METKLNVGLVRGHAYSFTGVKNVPLKGTGLFSMFNRETIQMVRLRNPWGGTEWTGPWSDGAPEWTKVSEREKKELGLTFDENGEFWMAFDDFCRYFTHIDICHMMNTAFFTLKRSWKETTEFGEWRRGGRAGGCGNHQTFLENPQYLLEVYEDQEMRISLEQEDRRSSNFRTRGENYCIGFSITKTDLNRKYRMHDRMERVHSGSFVQARSILARMDMKKGKYLLVPSTFDPNQEGEYLLRIYSEGGMALRKLTKDVPSPPRMMKKPKIAATSVTVHAAEGFTFSEGETGIEAYCIIKCEKDQVKTSITEKHAKPEWKERVTFYRQNQTEDVVVEVWDDNLLKDSLVGSVTFPMEKSHEYTGGNIIRRYPLMKSNAEGVEELRGFLWASIKHTTNLMDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AYR9</accession>
    <name>A0A3S1AYR9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,3/1,6-mannosyltransferase ALG2</fullName>
            <ecNumber evidence="10">2.4.1.132</ecNumber>
            <ecNumber evidence="10">2.4.1.257</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_020464</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>a beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19511"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58472"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="EC" id="2.4.1.132"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8 10">
            <dbReference type="Rhea" id="RHEA:29516"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29519"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="EC" id="2.4.1.257"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9 10">
            <dbReference type="Rhea" id="RHEA:29520"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.132" evidence="10"/>
    <dbReference type="EC" id="2.4.1.257" evidence="10"/>
    <dbReference type="EMBL" id="RQTK01001161">
        <property type="protein sequence ID" value="RUS71770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AYR9"/>
    <dbReference type="STRING" id="188477.A0A3S1AYR9"/>
    <dbReference type="OrthoDB" id="448893at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004378">
        <property type="term" value="F:GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102704">
        <property type="term" value="F:GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03805">
        <property type="entry name" value="GT4_ALG2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000085">
        <property type="entry name" value="alpha-1,3/1,6-mannosyltransferase ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027054">
        <property type="entry name" value="ALG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918">
        <property type="entry name" value="ALPHA-1,3/1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918:SF1">
        <property type="entry name" value="ALPHA-1,3_1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="12">
        <location>
            <begin position="13"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="11">
        <location>
            <begin position="210"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS71770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="402" mass="45489" checksum="8859CE928155B6F8" modified="2019-04-10" version="1">MVRVVFIHPDLGIGGAERAVVDAALALKSRGHEVEFVTSHHDPSHCFQETKDGRLKVTVAGDWLPRKVFNRFYALCAYIRMIYVAAYLVFFSSIRYDLIFCDQISACLPILKLKSAKVIFYCHFPDLLLTQRKTFWKRMYRAPIDFIEETTTGMADCILVNSKFTASVFHETFTRLRQIEPEVLYPIPDFSAFDLPVDAPDASLMPLGVKTTFLSINRYERKKNIPLAIKAFGKLMEKRPKADACLIIAGGYDSRVAENVEHHDELVSLCKSLQLDQRVTFLRSFSDAQKRTLLKHSTCLIYTPDREHFGIVPIEAMYMRCPVIAIRSGGPLETIGDTETGFLCSPDNEEEMAAAMLQFVEDPDLSSTLGEAGRSRVTNMFSFVNFTNKLDSIVQYLTTGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AZ84</accession>
    <name>A0A3S1AZ84_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_016317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000700">
        <property type="protein sequence ID" value="RUS75929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AZ84"/>
    <dbReference type="STRING" id="188477.A0A3S1AZ84"/>
    <dbReference type="OrthoDB" id="6145267at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="1">
        <location>
            <begin position="607"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS75929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1265" mass="141548" checksum="32E4056EC607AEB2" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B057</accession>
    <name>A0A3S1B057_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_019357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001005">
        <property type="protein sequence ID" value="RUS72883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B057"/>
    <dbReference type="OrthoDB" id="4525710at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS72883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="119" mass="13326" checksum="F73DB52394CDB41B" modified="2019-04-10" version="1" fragment="single">MESVSLMIRVNISSKSFFFNTFSWIALLLMVDRLANPFSRDAILYSMVPSLSSNRFNSSNEVLLQSCASLSMADRLEPASPFSRDAILAPNRSSFIIIKEVLREPCAVGILRPCFCTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B568</accession>
    <name>A0A3S1B568_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL20m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">39S ribosomal protein L20, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_020037</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the bacterial ribosomal protein bL20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001098">
        <property type="protein sequence ID" value="RUS72210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B568"/>
    <dbReference type="STRING" id="188477.A0A3S1B568"/>
    <dbReference type="OrthoDB" id="10251781at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1900.20:FF:000001">
        <property type="entry name" value="50S ribosomal protein L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.20">
        <property type="entry name" value="Ribosomal protein L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005813">
        <property type="entry name" value="Ribosomal_bL20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035566">
        <property type="entry name" value="Ribosomal_protein_bL20_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01032">
        <property type="entry name" value="rplT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10986">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00453">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00062">
        <property type="entry name" value="RIBOSOMALL20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74731">
        <property type="entry name" value="Ribosomal protein L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00072767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00076245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS72210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="158" mass="18602" checksum="1A9CC4B37603FC7D" modified="2019-04-10" version="1">MVFLTLALLRVGKNKMTPYSMREWKRVMQRRLSWHFRNRKRNCYRLSLCPVKKSLRFSTTVRPIRRRNINHLFTNRIAAGCAQHGVQYSSFMRALYESNILLNKKMLAQLSIYEPRSFQSLCEFAKKRHSELVQKGLAVALEPLPSGIITRDMIKKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B579</accession>
    <name>A0A3S1B579_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_016969</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000756">
        <property type="protein sequence ID" value="RUS75277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B579"/>
    <dbReference type="STRING" id="188477.A0A3S1B579"/>
    <dbReference type="OrthoDB" id="6126208at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS75277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="17633" checksum="158773EF618680B2" modified="2019-04-10" version="1" fragment="single">MIQLDIDADEVRYIDLNIVKNDQHFFPGMAEDEGSASNDFTHEPGVSREEITRRYAQWANSSKYEKDLREEVYQGPSIAADTVAHYFPDENSRKTARILDVAAGSGFVGEKLKNKGFETIHALEPCGQMLQLALEKGVYSKTFQNYLNGHALDIESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B777</accession>
    <name>A0A3S1B777_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Catalase</fullName>
            <ecNumber evidence="11">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EGW08_014618</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">EC2010</strain>
            <tissue evidence="15">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 11">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="11"/>
    <dbReference type="EMBL" id="RQTK01000566">
        <property type="protein sequence ID" value="RUS77618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B777"/>
    <dbReference type="STRING" id="188477.A0A3S1B777"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08156">
        <property type="entry name" value="catalase_clade_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000001">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040333">
        <property type="entry name" value="Catalase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF9">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="7 11" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="4 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="14">
        <location>
            <begin position="25"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RUS77618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="503" mass="56748" checksum="BA395754A558873A" modified="2019-04-10" version="1">MANRDRAAEQMNEYKKTQARPDVLTTGTGAPVGNKNASLTVGPRGPILLQDFVFTDEMAHFNRERIPERVVHAKGSGAFGYFEVTHDITKYCKAKVFEQVGKKTPLAIRFSTVGGEKGSADTARDPRGFAMKFYTEEGNWDLVGNNTPIFFIRDPILFPSFIHTQKRNPVTNLKDPDMFWDFISLRPETTHQVSFLFSDRGTPDGYRHMNGYGSHTFKLVNKEGQAFYCKFHCKTDQGIKNLMADRAGDLSGTDPDYAQRDLFNAIDEGNFPSWSMYIQVMTFEEAEKSAFNPFDLTKVWPQGKYPLIPVGRLVLNRNPKNYFAEVEQIAFSPAHMVPGIEASPDKMLQGRLFSYSDTHRHRLGSNYLQLPVNCPFNTKMRNYQRDGPQCVDDNQGGAPNYFPNSFSGPQDMLDKVESSYKLTGDVGRYNTADDDNFSQTGIFWKKVLSPEARARLVDNIAGHLKDAQDFIQKRAVGNFAQADADFGKALRMALDKFQTPSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B7S7</accession>
    <name>A0A3S1B7S7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Complex I assembly factor TIMMDC1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Translocase of inner mitochondrial membrane domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_015126</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000609">
        <property type="protein sequence ID" value="RUS77110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B7S7"/>
    <dbReference type="OrthoDB" id="6157625at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055299">
        <property type="entry name" value="TIMMDC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13002">
        <property type="entry name" value="C3ORF1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13002:SF1">
        <property type="entry name" value="COMPLEX I ASSEMBLY FACTOR TIMMDC1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS77110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="336" mass="36972" checksum="B0B48DAF5C30B188" modified="2019-04-10" version="1">MEKSEDELFSMHFYLLKKVREKSGPASLCAPLVMFKLKDYCTCNNIAQTQSIKKSVSMDLLTKPLAGLWLALSSKLCTAARCSTSNSYADTRPEDYTIGALHEDEDEDWDSGLPGMRRRRQTNRASSKNSAVTDMQVNQQIELETGLQRLREMYSLGPDWMFVQEDTRTITTIFYRSVMLGFLLNVVKAAQAESKSSKNKNISPSQAVMKMGTNSMSDSTRVIKEAARGSVRLTAFAASLLYLSQSIAAYRNQSSVWEYSISTAVAMACAGFGKPPRTFTLSVLGGAIAGALGGSLVCSMLSSVGASQEQRTLNRIRQKLGQQQQQQTLTIDDGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B8N3</accession>
    <name>A0A3S1B8N3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-rRNA-processing protein Ipi1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_013628</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IPI1/TEX10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000499">
        <property type="protein sequence ID" value="RUS78622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B8N3"/>
    <dbReference type="STRING" id="188477.A0A3S1B8N3"/>
    <dbReference type="OrthoDB" id="361362at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071339">
        <property type="term" value="C:MLL1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024679">
        <property type="entry name" value="Ipi1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF2">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12333">
        <property type="entry name" value="Ipi1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein Ipi1 N-terminal" evidence="4">
        <location>
            <begin position="153"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS78622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="776" mass="86839" checksum="119FF35F42D3E068" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BAI1</accession>
    <name>A0A3S1BAI1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_008486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000232">
        <property type="protein sequence ID" value="RUS83735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BAI1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS83735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="679" mass="75457" checksum="014C184C8E7C373B" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BEJ2</accession>
    <name>A0A3S1BEJ2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_005705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000136">
        <property type="protein sequence ID" value="RUS86513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BEJ2"/>
    <dbReference type="STRING" id="188477.A0A3S1BEJ2"/>
    <dbReference type="OrthoDB" id="10025511at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
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</entry>
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</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
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                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
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                <person name="Altenburger A."/>
                <person name="Shibata T."/>
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                <person name="Shigenobu S."/>
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                <person name="Yang H."/>
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                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
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        </source>
    </reference>
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        <subcellularLocation>
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        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273:SF4">
        <property type="entry name" value="AT19640P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273">
        <property type="entry name" value="MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="65"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS82492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="379" mass="42986" checksum="79A524F9C7E64D19" modified="2019-04-10" version="1">MAYTISNVNATPWISFGMTSVSPTTADVSNVSTEQTPSDLDRFQDVYRPIHGVAAPIICILGIIANCLNIVVLTRKNMVSPTNVLLTWLAISDGLTMMAYLPYVILNYHIYINSAGPLSNARFIMFFAIFSVIVHSISIWLTVSLAVFRYVFIRYPRRGAKLCSIYRAKLTVFIVCVVVTLVCIPNSLSYTFFKVEKNDMTFWYIDVRRDTPGYQFLKNFNLWIQAILVKLLPCLLLAVLSILLIKQMKDAEKRRKKLMNKSNSKAEDDSRRHRKTNRTTKMLVTVVVLFVLTETPQGILQLLAGIIDGFFSKVYGPLGDLMDTLALFNNGINFVLYCTMSKHFRDTFIKIFLSDIVKSSTLRTDTQLMAARTTRVSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BKB6</accession>
    <name>A0A3S1BKB6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_023044</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001785">
        <property type="protein sequence ID" value="RUS69193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BKB6"/>
    <dbReference type="STRING" id="188477.A0A3S1BKB6"/>
    <dbReference type="OrthoDB" id="506011at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042512">
        <property type="entry name" value="TLCD5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31898:SF1">
        <property type="entry name" value="TLC DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31898">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="32"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS69193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="305" mass="35142" checksum="18CC7D9D9703615A" modified="2019-04-10" version="1">MLQINSFDLYQILIYAFTWTTLYFLLCLCNSRRSYEWHCRMVTVVHATLISSLAIYSTFFSGPWPFSESGGPNTSLQVRTVSLCLGYFIFDFCWCMYFKTEGPVMVAHHFLSIVGLTWCLIAGHYGTELVCTIGGAEITNPLLQLRWFLRELGHYKGTIWGHIVDWAFMLSFGFIRIVLGSILLYSYYQQNTDFWGRLGGTTIYSIGWIFFINILSYAFRKYLRIYKDWVKMKKGSTRNGNVKGLRTTFDSQNREDNFISNGNRKNGGVPVIPEREIPSQREIKNGVASLTPRESLVVRDCPGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BLI1</accession>
    <name>A0A3S1BLI1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">von Willebrand factor A domain-containing protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_022330</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Exhibits ATPase activity in vitro.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001540">
        <property type="protein sequence ID" value="RUS69908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S1BLI1"/>
    <dbReference type="OrthoDB" id="5186at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000587">
        <property type="entry name" value="von Willebrand factor A domain containing 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000663">
        <property type="entry name" value="von Willebrand factor A domain containing 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039891">
        <property type="entry name" value="VWA8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21610">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21610:SF9">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="VWFA" evidence="9">
        <location>
            <begin position="1652"/>
            <end position="1850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1471"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1471"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00055988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS69908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1860" mass="208326" checksum="89DB7BB29269D00F" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BM82</accession>
    <name>A0A3S1BM82_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine/arginine repetitive matrix protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_000648</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000009">
        <property type="protein sequence ID" value="RUS91533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="188477.A0A3S1BM82"/>
    <dbReference type="OrthoDB" id="163257at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Serine/arginine repetitive matrix 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036483">
        <property type="entry name" value="PWI_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052225">
        <property type="entry name" value="Ser/Arg_repetitive_matrix"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148">
        <property type="entry name" value="SERINE/ARGININE REGULATED NUCLEAR MATRIX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148:SF0">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00311">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101233">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51025">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWI" evidence="5">
        <location>
            <begin position="25"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="162"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="203"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="275"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="440"/>
            <end position="487"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="495"/>
            <end position="507"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="549"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="581"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
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            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="727"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="739"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="810"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
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            <end position="868"/>
        </location>
    </feature>
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        <location>
            <begin position="893"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="907"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="932"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="973"/>
            <end position="993"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00067280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS91533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="993" mass="113353" checksum="FA4C4C53EE953992" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BNK7</accession>
    <name>A0A3S1BNK7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_004350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000098">
        <property type="protein sequence ID" value="RUS87872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BNK7"/>
    <dbReference type="OrthoDB" id="8960888at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS87872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="144" mass="16324" checksum="7EF10ABE5871234A" modified="2019-04-10" version="1" fragment="single">IIGINKSPRQIFGINNVPRQMIVINNSPRQIIGIINSPRQIIAINNSPRQIISINNSPRQIIRTNNLPRQMIGINNSPRQMIGINNSPRQIISTINSLRQIIGNNISPRYMSGINNSPRQILGNNNSPRQMVYVYISTRKNNSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BSZ3</accession>
    <name>A0A3S1BSZ3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_004219</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Neurotrophin receptor-interacting factor homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF34">
        <property type="entry name" value="PR_SET DOMAIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="355"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="383"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="411"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="439"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="467"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="89"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS88053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="571" mass="64335" checksum="E0F2F3F805BE6577" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BU87</accession>
    <name>A0A3S1BU87_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_000555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000007">
        <property type="protein sequence ID" value="RUS91729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BU87"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS91729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="202" mass="21691" checksum="21B14D8A3D22F46B" modified="2019-04-10" version="1">MDAKGPSKVSPPILPMYSSVCMHQNLSLLTHSPRRTLAVEGADPVVAGAPVSALLFIPGLTSPPQVQLKPWTRGLEPGPGYSRRLGRRKMLIRGGWEGLARIKGRCGPALGVPCTVTVVRVFKARVAADPGLHALQGLQNLIPLLGGSIRAFLVQALGLPDKQTRSGPGQRRDTRFKPPGKHQNVHRQERKGVLEHGDSHSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BY99</accession>
    <name>A0A3S1BY99_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_000443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000005">
        <property type="protein sequence ID" value="RUS91872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BY99"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS91872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="270" mass="30822" checksum="D0EE9D6254B24D45" modified="2019-04-10" version="1">MNKENDTKDAMFNFHFCHFDPCSIVYISSVLHRTHCIYLLISTFSLLLLLYFFTKFIFLWSLPLTHFLDIYFGKFHLKKLDFTMATNGRLNVDQTLSSEDIAVKLNRHNFCTASSDDVEALLEHKHNFMDLKLDGEESVSENESETEELTNSDSEGETQFNPIEDFDSTSLGAGGPLAVLPLVQTTQQVPPKKCPCKCKLNNSKPCIDRYSWSLSPTMLRSMPSPFLTVPLSIGIPICGYYPPTAPKKRCMISTWRLPVRARRQRGSLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C3L6</accession>
    <name>A0A3S1C3L6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Neurotransmitter-gated ion-channel ligand-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">EGW08_010167</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">EC2010</strain>
            <tissue evidence="18">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Synaptic cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000305">
        <property type="protein sequence ID" value="RUS82059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C3L6"/>
    <dbReference type="STRING" id="188477.A0A3S1C3L6"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="16">
        <location>
            <begin position="20"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="17">
        <location>
            <begin position="186"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="352"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RUS82059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="470" mass="53809" checksum="07BDA2BB0A126691" modified="2019-04-10" version="1">MFALLETTYGLTKHIELSFEDKLIKKLVARYKRRGRWGRPLQHYNDTITVYYNMQLIQIMDLDERNQVLTLNVWDRYIWYDMHVMWDPQEFGGVDTIRIPSDQIWIPDIKLYNYSSSSSSSSSSSSSSSSSSRVVVAVYSLWFLHLPPQVPAVRNCQFYTCCPEPFIDLTFSIIFQRRSAFYNYILILPCILLTSLTLVLFWIPPESPAKLMLGINIFVAFFLLLLLMEANLPPSAAKVPLLGTYYCLNMILITLSSFLNAFVVNLSFYGARRPLPNCMRKVMFEFFAKILFMESLVRPFNDKTITMLAGRLVGDRRTFLGVMPPVNGDKVGRAASKWAPADAISPASEALLSGQGQGQGEGQGQSHQQQQLQPQPQPQPIENEPQQTMQLNVINYNLGELVDFIKTYRERVSEKDRKDRVAKEWKAVSLIFDRIFFIVYLTTIITSLFVILPIITNPDIPPKTEAINQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1CA75</accession>
    <name>A0A3S1CA75_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_005040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000117">
        <property type="protein sequence ID" value="RUS87200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1CA75"/>
    <dbReference type="STRING" id="188477.A0A3S1CA75"/>
    <dbReference type="OrthoDB" id="408743at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="2">
        <location>
            <begin position="19"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS87200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="109" mass="12269" checksum="BAC7C0A014B64356" modified="2019-04-10" version="1" fragment="single">QGTRFQWLPDGCLKTVSAPLDAIKEDPRNGKKVWFNSIIAVYRGWRDSRNDPNKAITFGDGTPMPPEVMDGLDAILEDLAADVTWQSGDVYLVDNMQVLHARRPFTPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H852</accession>
    <name>A0A3S1H852_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_018163</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000869">
        <property type="protein sequence ID" value="RUS74073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H852"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS74073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="657" mass="72673" checksum="CD0744CAC2E84E04" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H8B3</accession>
    <name>A0A3S1H8B3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome non-ATPase regulatory subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">26S proteasome regulatory subunit p27</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_018068</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit p27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000858">
        <property type="protein sequence ID" value="RUS74179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H8B3"/>
    <dbReference type="STRING" id="188477.A0A3S1H8B3"/>
    <dbReference type="OrthoDB" id="72325at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000107">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040815">
        <property type="entry name" value="Nas2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035269">
        <property type="entry name" value="PSMD9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18265">
        <property type="entry name" value="Nas2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="108"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS74179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="206" mass="22667" checksum="C7DC78127A6DFE9C" modified="2019-04-10" version="1">MAATTKYKSLCKKKEEIEGEIKELLDLLESQKGVGLKEPLTDAEGFPRADIDVYSCRHARHQISCLQNDHVAIMKDIEEELNNIHQQAREQKSQTDMLAESVSSCIDGTASMEIDRLPFAVVDRVDPGSPAAYGGLEIGDQLIEFGSVMSENFDGLQMLASVMQHSKGRPLRCVVLRNGRKAALNVTPNTWSGPGLLGCNIKPNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HEX7</accession>
    <name>A0A3S1HEX7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_014254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000539">
        <property type="protein sequence ID" value="RUS77993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HEX7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS77993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="115" mass="14183" checksum="5B257A4A087AE4F2" modified="2019-04-10" version="1" fragment="single">THYSMYSYTHYSVYNYTHYSVYSYTHYSVCHYTHYSVCHYTHYSVCHYTHYSVYSYTHYSVYNYTHYSMYNYTHYSVYSYTHFSMYSYTHYSITAIHIIPCTNIHIIPCTITHII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HJ30</accession>
    <name>A0A3S1HJ30_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Replication protein A subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EGW08_011808</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">EC2010</strain>
            <tissue evidence="15">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the heterotrimeric canonical replication protein A complex (RPA).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the replication factor A protein 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000391">
        <property type="protein sequence ID" value="RUS80439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HJ30"/>
    <dbReference type="STRING" id="188477.A0A3S1HJ30"/>
    <dbReference type="OrthoDB" id="1751331at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04474">
        <property type="entry name" value="RPA1_DBD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04475">
        <property type="entry name" value="RPA1_DBD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04476">
        <property type="entry name" value="RPA1_DBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04477">
        <property type="entry name" value="RPA1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000041">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000064">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000090">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000117">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047192">
        <property type="entry name" value="Euk_RPA1_DBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013955">
        <property type="entry name" value="Rep_factor-A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007199">
        <property type="entry name" value="Rep_factor-A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031657">
        <property type="entry name" value="REPA_OB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004591">
        <property type="entry name" value="Rfa1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00617">
        <property type="entry name" value="rpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165:SF4">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04057">
        <property type="entry name" value="Rep-A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08646">
        <property type="entry name" value="Rep_fac-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16900">
        <property type="entry name" value="REPA_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Replication factor-A protein 1 N-terminal" evidence="12">
        <location>
            <begin position="3"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="OB" evidence="11">
        <location>
            <begin position="195"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Replication protein A OB" evidence="14">
        <location>
            <begin position="302"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Replication factor A C-terminal" evidence="13">
        <location>
            <begin position="457"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RUS80439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="611" mass="68399" checksum="9FDDC80F842D748A" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HWN2</accession>
    <name>A0A3S1HWN2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_004614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000105">
        <property type="protein sequence ID" value="RUS87629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HWN2"/>
    <dbReference type="OrthoDB" id="7472380at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS87629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="531" mass="59023" checksum="18CDAB2D9F87DC17" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HXI5</accession>
    <name>A0A3S1HXI5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_004103</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000092">
        <property type="protein sequence ID" value="RUS88141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HXI5"/>
    <dbReference type="STRING" id="188477.A0A3S1HXI5"/>
    <dbReference type="OrthoDB" id="6781428at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS88141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="218" mass="24928" checksum="ED4DC014FB19BADA" modified="2019-04-10" version="1">MHSSTPSPIDVTDVNVSNFDWRICSMEKKDRYALAKPQLDKLLHLKYYLICYKSLKRRVCVEKFNVTFDYPWKDACSSCDNYKVELSKELPADELRRLAAERELHWRKSQVFYERKTTAAQEAQSSPQHAAAAFDFWTHFPCPNISTLDVYYKRQLSLCRGKARGEKESSADTPTALQPNTDVVTAARYKDLPTLKAFLLSGIANLLQPAATPRRATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SII6</accession>
    <name>A0A433SII6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_023600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01002167">
        <property type="protein sequence ID" value="RUS68637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SII6"/>
    <dbReference type="STRING" id="188477.A0A433SII6"/>
    <dbReference type="OrthoDB" id="6022054at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033596">
        <property type="term" value="C:TSC1-TSC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007483">
        <property type="entry name" value="Hamartin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15154">
        <property type="entry name" value="HAMARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15154:SF2">
        <property type="entry name" value="HAMARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04388">
        <property type="entry name" value="Hamartin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="321"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS68637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="416" mass="46777" checksum="9B7944D352B0C448" modified="2019-05-08" version="1">MTSQTEVTAESVRQFMKKVNRIRFNSLTSNSSSNEEVDIVLYPLPGQVRRRPRSCPPFKRSKSASSLSGAENSPPPRRPHNRLSRLIPPGGARKGRKLAPVDRSVPLQQRGGNKVVFVSQKSVPVDGNYPSDVAQSEDSSDDVVSCDSSKDTPRKVCTAGHGAKHQEEQTSDQMTVPLLDVVPALPEGVNAVFQCILAPSKLAICNNCHQQLVVTSNFSAEPDQTLSGKEIALFSRVAPPELLDRHLKLGSDLHAKELTKIPLTSKESVNWTHFGGLPPADEVSILRGQILLMQTQILYERHKRCNHAKRNRRLLRRMTNIASLEEQQKSLMSKLGLFEEEVQQLNISVRLLQEDNRRLAQRRESDEYEKLVEFRTSLKENKDLKASSVVLKNLLLTQREDYDKQQKVWVELELVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SIZ2</accession>
    <name>A0A433SIZ2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_023243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001882">
        <property type="protein sequence ID" value="RUS68994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SIZ2"/>
    <dbReference type="OrthoDB" id="10002384at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030336">
        <property type="term" value="P:negative regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031466">
        <property type="entry name" value="MIIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34831">
        <property type="entry name" value="MIGRATION AND INVASION-INHIBITORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34831:SF1">
        <property type="entry name" value="MIGRATION AND INVASION-INHIBITORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15734">
        <property type="entry name" value="MIIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS68994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="663" mass="73775" checksum="2B35A402A62AF13F" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SIZ9</accession>
    <name>A0A433SIZ9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_023223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001865">
        <property type="protein sequence ID" value="RUS69015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SIZ9"/>
    <dbReference type="OrthoDB" id="6088005at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS69015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="125" mass="13161" checksum="D5837D1FA0615176" modified="2019-05-08" version="1" fragment="single">MDGTGTTEALEGVVTKVIDLITGTTETVPEELVANWTSSANWTSSTSLPTTTTTLGTTTTTKKPCYVWTQPPCDSLVKGAYDLATYGVYVAYAIGIPGSILTLIVLARMTPFNSSSAWLSCLATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SJD6</accession>
    <name>A0A433SJD6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_023213</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001860">
        <property type="protein sequence ID" value="RUS69025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SJD6"/>
    <dbReference type="STRING" id="188477.A0A433SJD6"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008069">
        <property type="entry name" value="Cyt_P450_E_grp-I_CYP2D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF375">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01686">
        <property type="entry name" value="EP450ICYP2D"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS69025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="39023" checksum="482A3C762505D579" modified="2019-05-08" version="1" fragment="single">ISAYIDVLSTYRGEPRDVSLLTKTAVANVICSIIVGRRFEYDDAYFVTFIQKLDELFHLSESSSLFTVFPWLRYLPGDLFDAKRRTGIYRYIMDLFCYHYINKAKQDGEDVTESFITAYLQEEKKMKEQGQKSTLDDENLARNIIALFLAGTDTTSTLLQWFLLYMLHYPDAQSKIFAEISEVIGLERPPSLQDKFKLHLTNAAIIETQRISTTPFNLPHACNEDTVVKGYTIPAGATVITNLDSIFLNENIWKDPWTLKPNQPTNQLTLHVCELHSCYPGRRACPGESLAKMEIILFVTSLLQRFELRPEEPGRLPSLEPTQGMIFAPKPFKIRCVDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SKB6</accession>
    <name>A0A433SKB6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_022695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001647">
        <property type="protein sequence ID" value="RUS69544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SKB6"/>
    <dbReference type="OrthoDB" id="6043889at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS69544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="123" mass="13519" checksum="E6A92A62C3876D40" modified="2019-05-08" version="1" fragment="single">MKNDAFWKEGQPDSYLDSVDCVAAMIPSIIVQLDDMSCYNYLPFVCQLFPEKCPYDRYGPNCSEHCSPYCVGSSCDSSTGHCMSGKCASGYEGKKCDSHCSTRTFGKKCSKTCSPTCLGDNDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SLN6</accession>
    <name>A0A433SLN6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_022156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001496">
        <property type="protein sequence ID" value="RUS70081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SLN6"/>
    <dbReference type="STRING" id="188477.A0A433SLN6"/>
    <dbReference type="OrthoDB" id="10255522at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1480.30">
        <property type="entry name" value="Designed four-helix bundle protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58104">
        <property type="entry name" value="Methyl-accepting chemotaxis protein (MCP) signaling domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS70081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="101" mass="12482" checksum="6B551BC846DDE3FE" modified="2019-05-08" version="1" fragment="single">FEHIKQYLQHIKQYLEHNEQYLEHIKQYLEHIKQYLEHIKQYLEHIKQYLEHIKQYLEHIKQYLEHMKQYLNILSSILNILSSILNILSSILNILSSIVNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SME9</accession>
    <name>A0A433SME9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_021896</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001431">
        <property type="protein sequence ID" value="RUS70343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SME9"/>
    <dbReference type="STRING" id="188477.A0A433SME9"/>
    <dbReference type="OrthoDB" id="423607at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050648">
        <property type="entry name" value="F-box_LRR-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13382:SF80">
        <property type="entry name" value="F-BOX AND LEUCINE RICH REPEAT PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13382">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE COUPLING FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="235"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS70343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="616" mass="67947" checksum="44C7AEA022E522BF" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SMN3</accession>
    <name>A0A433SMN3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_021814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001412">
        <property type="protein sequence ID" value="RUS70424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SMN3"/>
    <dbReference type="OrthoDB" id="6208413at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="56"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS70424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="410" mass="46692" checksum="E912E6C996AAAF2B" modified="2019-05-08" version="1">MDGSIFRCKTKCIIGIGVDLYFEREILLSYPRRKCDYGRYQFEYPCKYTDYLDLSDAGICIKTVNSVVPWREAKARCVHRYKGTLIKITSKAMNDEINKLNFLSSGGYWIGLSNIWLRHLHNDTFGWLDETQPATYMNRFKNPLGTSTGEEWCVITEPGDYWDKAKCYPNEHEFICQKMSARNPGPPSLSFKFSHGHRHAYIGYDLHAQCSAFTELGASVKFRMEDNINLTEIGSHDIDYTSLAVEQFVEVDDRCLPMTIADLKVKVTTRLLGTDFKCCWYLQETLMSCSDSIRATLRYLPKRPVLTVKSSYYLSIGDHVTATCSACVGTGGQLVWALDMLDVKLQWSSQFYSTQDSPPFPGGRSVSPQTTSLVEGWIPPILFFFLNQTCISLRSVYLHHVVNLNCASIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SMV2</accession>
    <name>A0A433SMV2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_021734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001393">
        <property type="protein sequence ID" value="RUS70509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SMV2"/>
    <dbReference type="OrthoDB" id="5912026at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.75.10">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036645">
        <property type="entry name" value="Elafin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00095">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00217">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57256">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51390">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WAP" evidence="1">
        <location>
            <begin position="150"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="1">
        <location>
            <begin position="241"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS70509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="291" mass="32037" checksum="EDB26D2377DEB66D" modified="2019-05-08" version="1">MGRDTVLFGNFHTGLYPGLHNHDSDNHILLNHGPLLHMRSRLSRLCLYTICPSGMECRALQDCPSCTPKAKCMRSNFIPPGPDWSCKFSGFQQALFLDSIYPGYPLRARLCSDVGDSMLNTPRARCPAGAACVARRGGRSLCCFNQHLPVRSKPGFCPSQPGLDRPTCGGDFCRTDYNCPGEQKCCTNSCGTNVCMGSTISTCGRCPLDTECQKVERTCVSPPCSLVYECVSIRMKESVGTSQHDSCPTVTQPFCSSNQRVDQCLSDLDCKRTDTCCFDGCVRRCRYTLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SNJ9</accession>
    <name>A0A433SNJ9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_021474</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001338">
        <property type="protein sequence ID" value="RUS70772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SNJ9"/>
    <dbReference type="OrthoDB" id="6038972at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.160">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS70772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="188" mass="21596" checksum="D6AE0FF9EC6E2CBA" modified="2019-05-08" version="1" fragment="single">GDYCECKEGICSKEWDEGDGTSLAWQHYERAHWSVQYKLCRPLFQDKPDCEGDELGAQVQTAVAEWSPDLTVPRCVCPEKGLYRLTGWKRPNKGAIWEYYYTCDKRECPLPPQKPGGEKVECARIYVDAGKRSDKVLEMRFACSCPEGYLCPAKYNDKEDDSRLESDADHASYVPKHCEPIVKRKRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SNN5</accession>
    <name>A0A433SNN5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_021425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001330">
        <property type="protein sequence ID" value="RUS70805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SNN5"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37558">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37558:SF1">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="193"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="81"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS70805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="240" mass="28520" checksum="8E54A59D2947B6DB" modified="2019-05-08" version="1">MPPKMFRFNEERDLCLLRETRCINPFTNPPKGWIEVFENLLFSGFFPADCSASQRTCRQRVELLMGQFERLKKIRLASSGIEEEILEKDKLLEELLELRDEALRETKEAAGEKKNTDAELGRLIRDQAMQAMVSEEKADAIDDATCSSTTPKGKKRKRLSGLAESEEWTQYMQRREEDRKMIKQKELELRQMELDHAKQREEEDRRERAEIRRLQAEREERDREERTKMMEMMLQALSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SQ10</accession>
    <name>A0A433SQ10_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_020911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001232">
        <property type="protein sequence ID" value="RUS71326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SQ10"/>
    <dbReference type="STRING" id="188477.A0A433SQ10"/>
    <dbReference type="OrthoDB" id="509497at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14939">
        <property type="entry name" value="F-BOX ONLY PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14939:SF5">
        <property type="entry name" value="F-BOX ONLY PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS71326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="447" mass="50290" checksum="D41CB8AEC0F73DC3" modified="2019-05-08" version="1">MALQNDGCDASGSDKHINSFCDSHVSGDVLTNIIVVEKIFKCLNARQLNICAKVCKVWNYQAKREKESRVWMRWNLFSADHREQGDFDAKEWWSSVKSFILDSPIEPSFVLMFCTDALCCHLSEARQKKRKRSRAEPDILGLLNPILPKHCSFEVVMSEGVVGTDEKMKTEELQDYELALSVILFGKDSLKQPGFDVEFMPFTFSHDECKYLNKFWSEGSNIAPSFMQKMLRKEVKMVNLYCPIVQEVGYSFFRMLQCPLIAGGFVNNKYLRDNEGKVSSPVGHTVLAGFALCGSSVHVASVLIRSGIETEEEVDKVVRSLKDQNLPLEHSFGLMYACVEKGINNYESRNVESGMFRKHFPTTPLLGFFGNGEIGCNYPSPALPLSVKDNGVGAKDTNSNGQEQSRNQRKTLRSSVSKIMQADELKRPPKLLHAYTTVLCLVSISPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SRG3</accession>
    <name>A0A433SRG3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_020371</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001148">
        <property type="protein sequence ID" value="RUS71862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SRG3"/>
    <dbReference type="OrthoDB" id="106267at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF104">
        <property type="entry name" value="AT-RICH BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="8">
        <location>
            <begin position="44"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="BED-type" evidence="8">
        <location>
            <begin position="175"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="BED-type" evidence="8">
        <location>
            <begin position="308"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="BED-type" evidence="8">
        <location>
            <begin position="428"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="BED-type" evidence="8">
        <location>
            <begin position="538"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="BED-type" evidence="8">
        <location>
            <begin position="651"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="BED-type" evidence="8">
        <location>
            <begin position="771"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="BED-type" evidence="8">
        <location>
            <begin position="953"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="domain" description="BED-type" evidence="8">
        <location>
            <begin position="1077"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="112"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="366"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="602"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="843"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="366"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="486"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="602"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="843"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS71862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1178" mass="134655" checksum="E1B0F42CF10F5E1E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SSX4</accession>
    <name>A0A433SSX4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_019879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001076">
        <property type="protein sequence ID" value="RUS72363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SSX4"/>
    <dbReference type="OrthoDB" id="6091452at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS72363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="318" mass="34393" checksum="362F544402140622" modified="2019-05-08" version="1" fragment="single">DKCAALPPNTLFPDESACQKYWRCGSNQRLASSECCPAGQGFDQIAQRCVVNSQCPDVCGPCNNTSSTPTAGSGCPLAPVPGNPNRYYYVISPGTTLACPETLVFDAAICTCVVGQGVVVTSPQLCVPTFQTGFDIPLDYQNNIPTISYQGQQVGQFDGTGDLVIKAFAQSGFHTPHFQIDLRVNLANTVPPSGGQRMAVVTNADCETMESVSITMDAQNFYFRIYQMESTTPAEIAIPFAGLQDANGWYKVSLMYAGGPGSFQFTATVGSKTEVYRGPVLLDNYIDRRKCALHVGFGYMYAGFQGYLDDISIWRCKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433STG0</accession>
    <name>A0A433STG0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LRRNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_019738</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001060">
        <property type="protein sequence ID" value="RUS72510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433STG0"/>
    <dbReference type="STRING" id="188477.A0A433STG0"/>
    <dbReference type="OrthoDB" id="2013775at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF275">
        <property type="entry name" value="TIR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019057867" description="LRRNT domain-containing protein" evidence="4">
        <location>
            <begin position="32"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS72510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="556" mass="60190" checksum="58683F3B3A17FE9B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433STR9</accession>
    <name>A0A433STR9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MD-2-related lipid-recognition domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_019584</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001039">
        <property type="protein sequence ID" value="RUS72646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433STR9"/>
    <dbReference type="STRING" id="188477.A0A433STR9"/>
    <dbReference type="OrthoDB" id="6409159at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006689">
        <property type="term" value="P:ganglioside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.220.10">
        <property type="entry name" value="Ganglioside GM2 activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028996">
        <property type="entry name" value="GM2-AP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036846">
        <property type="entry name" value="GM2-AP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17357:SF0">
        <property type="entry name" value="GANGLIOSIDE GM2 ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17357">
        <property type="entry name" value="GM2 GANGLIOSIDE ACTIVATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63707">
        <property type="entry name" value="Ganglioside M2 (gm2) activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019499036" description="MD-2-related lipid-recognition domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="3">
        <location>
            <begin position="74"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS72646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="221" mass="23521" checksum="5FCBE5D7435623D2" modified="2019-05-08" version="1">MKTGYFILTAALVLLISASPSILDISDAELLAHTEFSKLARFLGDALQGRVSNTLYFEPSQEQRRRDSVGKFVFNNCADPKNEQVKVNTISLKPDPLKLPGNVTAGGAVTINSPVGSPLKVALDVYYKVFGAWIKVPCVDDIGSCTYDDFCKKINIASCPPEIVKAGLTCKCPFPAGNFSVSSATLPITASLPVSGDVKVEATATMSGKLVTCAQVQLTID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SZM8</accession>
    <name>A0A433SZM8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_017485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000802">
        <property type="protein sequence ID" value="RUS74756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SZM8"/>
    <dbReference type="OrthoDB" id="6157608at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS74756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="26027" checksum="0C8BB42EF39CAD78" modified="2019-05-08" version="1">MADDEEFDFFKPHPNPKPRVKTSFFEVVPDAFDDKSLTFTGDHRRTPKKVAPEPKEPETSPEPETEPKETKPAATSAAVAAMSGAGVQETMFSHDVCMTSAEPWSPGDRTANMNPYSRDQLGDKAAHWVGLKYYPEEKEIRWNGDPKREKSRRSEKETYCVMLTTPVRGIFLKVSCSEHVAYICGIRPRKNISIFIDPFADFRLSSLLRLKLCHNQNIMTKQVTATIVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T0J4</accession>
    <name>A0A433T0J4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_017174</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000774">
        <property type="protein sequence ID" value="RUS75068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T0J4"/>
    <dbReference type="STRING" id="188477.A0A433T0J4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019217200" evidence="2">
        <location>
            <begin position="37"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS75068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="288" mass="31812" checksum="367BC9D52B03C737" modified="2019-05-08" version="1">MAQHPHSLTMRSRGKVAAAALVWLVILVSSCPTGQAAGEYDEQKLDIWRQSILDVIDHKMTGMCQTMIRSVKQENQTPDSACGQLTSQRFLLKLTCSEAEAQALEDAVCGYSDIQLTTESSLETSSSSSMSNSLSSSSSAISSSSSSSSLSSSMLTSSSHHHHHHHHHHHHHHHHHHHHHQQQHHHHHYHQQQQHQKKKKKKKICHPRIPPNPSRLPLLPVLTVQTSPSLTGNSRAGTAASATSATKSCPSLPAFYTQVSTVRATAVNSCAILTTCRRKRKQTIKARM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T0J6</accession>
    <name>A0A433T0J6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_017183</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000775">
        <property type="protein sequence ID" value="RUS75047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T0J6"/>
    <dbReference type="OrthoDB" id="6125324at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050579">
        <property type="entry name" value="PMP-22/EMP/MP20-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671:SF108">
        <property type="entry name" value="CLAUDIN FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671">
        <property type="entry name" value="EPITHELIAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="252"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS75047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="30969" checksum="CEB6E427B1A29B06" modified="2019-05-08" version="1">MGMWQERSLVYKIGYVGANFASLLFIVAFCAPSWAVFKLSPNSGHHHEQSLGLWQVCTKSLSICTLAVHSENPGWLKAVRALECIAMFFAVTSCFIGLYSNCILKAQITSNIFNKNMETSAIVAVAFASFGLIMFASQIEKYYTFYSSEAGHIWWGFVLACLATALLGLSATLMLMAHKLRLLADLRRDQGGQFSHRQFSNSSFFSRVRLPNYSEAERDLTANVPREGDQGISVCPMPPAYETVVNCGVENAGTEEAPPPPYYQVVTAQSDSSSPSTALSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T0W8</accession>
    <name>A0A433T0W8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sema domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_017052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000764">
        <property type="protein sequence ID" value="RUS75193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T0W8"/>
    <dbReference type="STRING" id="188477.A0A433T0W8"/>
    <dbReference type="OrthoDB" id="6147782at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002116">
        <property type="term" value="C:semaphorin receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017154">
        <property type="term" value="F:semaphorin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031148">
        <property type="entry name" value="Plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625">
        <property type="entry name" value="PLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625:SF70">
        <property type="entry name" value="PLEXIN A, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sema" evidence="2">
        <location>
            <begin position="1"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS75193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="308" mass="32523" checksum="0855499A3714F9FC" modified="2019-05-08" version="1">MLCTSLFHGQCQTLRGSNITKSTGFSSQPVVPNDAGSSCVMFLGPQHDTASPDSGDSKPAAPRVLYVGAQFSSLGNRKYRDLVPSLSRRLLPSLELAHRDSNGSSRLSVRRAQRDSFPIQFVHGFHRGGFAYFLSTQPGGSQRGARLGRICEGDNYFRSYVEIPLECGAPGLTPDLVAGAAAVTADGGSLVVAFSPSGGGGPSQLCAFSLEDLDRAFNGTVASCYAGQGHVGPPHYRERQACEKTVSTGGGLGICVSVAGARPGKLWRHPVDLALDPGYLYPVSSHWILAMTRTAVNIEPSYGSNSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T1J4</accession>
    <name>A0A433T1J4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_016801</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000743">
        <property type="protein sequence ID" value="RUS75422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T1J4"/>
    <dbReference type="STRING" id="188477.A0A433T1J4"/>
    <dbReference type="OrthoDB" id="1683831at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043379">
        <property type="entry name" value="ANKAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46464">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46464:SF2">
        <property type="entry name" value="ANKYRIN AND ARMADILLO REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="194"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="746"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="753"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS75422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="811" mass="89259" checksum="A7B778CDDE2C09B3" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T399</accession>
    <name>A0A433T399_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_016193</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000691">
        <property type="protein sequence ID" value="RUS76037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T399"/>
    <dbReference type="OrthoDB" id="6078782at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="3">
        <location>
            <begin position="3"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS76037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="116" mass="12708" checksum="91AE4FB7696678DD" modified="2019-05-08" version="1" fragment="single">DYVIQLQFEQVSLLKDPHTRTCKERITVYDGPTSMYGVIGSFCDGTPEMVTASDEALIVFTPGTSQVNTSARIFTLKYRAVVERPHSGDTSHILRIGFGSFIGAIAFIVICSGVCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T4B3</accession>
    <name>A0A433T4B3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_015867</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000667">
        <property type="protein sequence ID" value="RUS76387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T4B3"/>
    <dbReference type="STRING" id="188477.A0A433T4B3"/>
    <dbReference type="OrthoDB" id="10069230at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21698">
        <property type="entry name" value="PROTEIN (PUTATIVE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21698:SF4">
        <property type="entry name" value="PROTEIN (PUTATIVE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS76387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="195" mass="23103" checksum="5BEDE1B2D597057D" modified="2019-05-08" version="1" fragment="single">TRRRLSYSRICRLSYSTICRLSYSFICRLSYSLICRLSYSVICRLSYSRICRLSYSTICRLSYSTICRLSYSRICRLSYSTICRLSYSIICRLSYSFICRLSYSIICRLSYSLICRLSYSRICRLSYSIICRLSYSITCICRLSYSRICRLSYSITCICRLSYSLICRLSYSRICSLSYSRICRLSYSCKNNARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T7M1</accession>
    <name>A0A433T7M1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_014644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000568">
        <property type="protein sequence ID" value="RUS77605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T7M1"/>
    <dbReference type="OrthoDB" id="10635884at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS77605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="327" mass="35930" checksum="E58F92CD90986E83" modified="2019-05-08" version="1">MPGLPLILEEDASLEQTKSPSVTPSSEISCPEQFLHHDTEPDDDRHYYEGSAKPQSGGNYFEKLSSKKNKVEEDPHSHPENGDSGTEMKILEEDENTTAATTAISSPPDVENSSSSSSSIGDNNNNSINNNNDNSNNNNIDEINSDELSSLHIDNWIEQIERANSVDTEVQDTNQPRGDTKQEAKDDPNSNSNPHPNQPKPSGGPLRRHHGQHRNNQSNQTRRPHSVQQVSSSTPSTAPDSKVRAHAGRPRPTQADPGERPLPQFSRSATVGVMESRASSRRSARGADQARDEDSGGASSALDLIHKYYHSMSQFSVHQAERKENEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TB96</accession>
    <name>A0A433TB96_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_013372</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000485">
        <property type="protein sequence ID" value="RUS78867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TB96"/>
    <dbReference type="STRING" id="188477.A0A433TB96"/>
    <dbReference type="OrthoDB" id="27823at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF7">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="74"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS78867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="135" mass="14848" checksum="1B3A494608FAFF55" modified="2019-05-08" version="1" fragment="single">FFSFCPEGDEDSELALEEGDVVRLVERVGDEWLRGELKGRQGIFPASFVEIIEDLPPGEETSPALSDPPGKTSKSDSTVKALYDFEDPPLGDLPFKEGDMIDVVEFIGEDWGRGLLNGKEGLFPLSFVAELEEVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TD18</accession>
    <name>A0A433TD18_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C3HC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_012757</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for proper positioning of a substantial amount of TPR at the nuclear basket (NB) through interaction with TPR.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000448">
        <property type="protein sequence ID" value="RUS79489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TD18"/>
    <dbReference type="STRING" id="188477.A0A433TD18"/>
    <dbReference type="OrthoDB" id="614844at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013909">
        <property type="entry name" value="NuBaID_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012935">
        <property type="entry name" value="NuBaID_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15835">
        <property type="entry name" value="NUCLEAR-INTERACTING PARTNER OF ALK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15835:SF6">
        <property type="entry name" value="ZINC FINGER C3HC-TYPE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08600">
        <property type="entry name" value="NuBaID_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07967">
        <property type="entry name" value="zf-C3HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3HC-type" evidence="8">
        <location>
            <begin position="62"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="NuBaID C-terminal" evidence="9">
        <location>
            <begin position="220"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="259"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS79489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="44271" checksum="336CAE4730DE1997" modified="2019-05-08" version="1">MGSPITPERIKGVLSSFLVKTEEQKSKQVGVDKSGADTNVQKDTPRAETVLSPKSNTAVLRSHNSFLKRLDTFSALTWFGKPAELSPLICARYGWENIEADMLQCTGCKTFLCGKLPPKTDIEEYNKTLEKLKKCLVTSHDRFCVLGCFPCPEEFCHVQVDDVLSLSTSFIERVSALGEIQDHLPRLDFAYLEDLGYDEGQAGAYCKRNLVTDKDISPAAVTLAFTGWACSSTNKEVLMCSMCRRKIGLWNFTPLGAGQRCDRGESSSEEGEEDSEPRVKRRKFASSTNKATLNPVDEHSHWCPWIREVLVSTKSLSSANLFPSSSPEPASSKSIPVFIAALKSIAPGLMDNNTGLAAGMKKSPMTEGLRCFRRALHTWSSPKTNTETGSPQQAQRIPAKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TEL1</accession>
    <name>A0A433TEL1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_012254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000417">
        <property type="protein sequence ID" value="RUS79989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TEL1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS79989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="150" mass="15968" checksum="38231664D7E97D95" modified="2019-05-08" version="1" fragment="single">MTIGEPSDFYSSLTIRTERGAVVQVIYRLACDTNFVGEDCATDCLQQPDLQVCSTQARYGLGGDRNHNASEQALRYFGSPLARCPLRPFRPKSTVSPTEPEGFPSPVATPSETLLPTKTLSPGDKSATPGLSSDGPGGSTTNLPSYETPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TG80</accession>
    <name>A0A433TG80_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_011679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000385">
        <property type="protein sequence ID" value="RUS80539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TG80"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS80539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="102" mass="12277" checksum="25378E9FDEC8F9D6" modified="2019-05-08" version="1">MHEIIMQHLTGQTICHYMRPYLIIHIKISCYSQVMVNFCHDILDCHSFYMPQDYKKYLFSCVNNCVTLVRETERVKGRHVCMFVCEGERKIEKGRRDKQSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TGU7</accession>
    <name>A0A433TGU7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_011453</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000373">
        <property type="protein sequence ID" value="RUS80783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TGU7"/>
    <dbReference type="OrthoDB" id="545169at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22538">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22538:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="360"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="87"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS80783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="385" mass="46141" checksum="B661689846C3AB83" modified="2019-05-08" version="1" fragment="single">MDTTNAKMMLGYMDDDDDEILDYDGNLDLSTDNEDEDEAESVQEYNMQQYPETPDEKIHWQEQIRMIHLRSHLNQLMEKVRHAHYVTDKTREELKKCRSQIQQYESERDDLFAEIQGKESEGNKSAVHRIRAAHQRVCGELEGEQNLEKMIIERLDQAEYELALAEVERGKFLLAEDDLLHREHKLSQEKTDMAMVRLAKEETLARQALTHRRKDDRTRRDVKLDAERRHAQAIEEAERSHERANKYLQKTMDKLKQREQQEAERYKTDMSKKMDMLLKLKNDITHNRENLRAIRARDKAAERKEMEEEKREREIIKMQGGNPEEMLLVKKRRNEVEKQRNQFEADQKLKKAAIMQKILTEEENIKRRRQQQPYLWKSPNKEADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433THB5</accession>
    <name>A0A433THB5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_011250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000362">
        <property type="protein sequence ID" value="RUS80975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433THB5"/>
    <dbReference type="OrthoDB" id="61870at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053225">
        <property type="entry name" value="Acyl-CoA_N-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013653">
        <property type="entry name" value="GCN5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20958">
        <property type="entry name" value="GLYCINE N-ACYLTRANSFERASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20958:SF6">
        <property type="entry name" value="GLYCINE N-ACYLTRANSFERASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08445">
        <property type="entry name" value="FR47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="156"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS80975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="296" mass="33414" checksum="AB4FF2BD8D35D22F" modified="2019-05-08" version="1">MDGCLHHVTTDELPDLRDWLVQYLPDSFKIYSVVKETINGRWQGTSLLTLGWPNILAVGEGPTSSQDIECAQYFNDPPLVSVFSPSHDHLKQLLTAPGYLDWTKPILFHFVCTRNTTTIQEVSESRGGNPQRAYRHGIKLIAKSGDIPLLPVPDGFEARALDPDTHTDLILSRWHHARKNADLYIRETLRRFPSVGLFDKRSGMCVAHEMGTKNGTIGRLYVHEDYRRRGLGKLTTSLLANQYFSQGLDVAILVFATNTLSLDMHSRMGFKVDGDGDFYTHYIGNPEDHEDILNFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TIL7</accession>
    <name>A0A433TIL7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_010782</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000337">
        <property type="protein sequence ID" value="RUS81442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TIL7"/>
    <dbReference type="STRING" id="188477.A0A433TIL7"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050778">
        <property type="entry name" value="Cueball_EGF_LRP_Nidogen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513:SF13">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513">
        <property type="entry name" value="VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS81442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="25513" checksum="52A400851D151140" modified="2019-05-08" version="1" fragment="single">RQLYFTNEGSTKPGLDGATYDWRRVERISLDKTWRMTVITDINEPRGLALDLTESMLFYLDKEKVKKSLLDGSDLKVILDGKLRDPNGLSFDEGHLYVTDSAEKNKSSSAQLLRLNVATGDRGDDWVPHKLSNNVSTPKGLAVHGDTLYYSDWSAEDPSTGSIKSFSIRFGVDNNVILSGMRPTGLHYSPLARRKQDSMEEWCAANTKCSNGCTKKIGTAPTCICPDQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TKQ8</accession>
    <name>A0A433TKQ8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_010078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000300">
        <property type="protein sequence ID" value="RUS82144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TKQ8"/>
    <dbReference type="STRING" id="188477.A0A433TKQ8"/>
    <dbReference type="OrthoDB" id="6370142at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052638">
        <property type="entry name" value="PiggyBac_TE-derived"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47055">
        <property type="entry name" value="DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47055:SF3">
        <property type="entry name" value="PHORBOL-ESTER_DAG-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="178"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS82144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="295" mass="33032" checksum="25F859756A2F8811" modified="2019-05-08" version="1">MKIMAKQHSAHEVLLMLEEEDFEEAEVILTPPGNGEGSDEDSGDEDQGGSFDNPPAAQLNAAATLWLLRRGGTLDRADDSDDNGLSKDDEDSNDALDPVPTKREKRAPVKRLWRKEDLTPKQKECIDLQPPSFLSKDLSPTQLFELFFDDEVIEDIVTLTTKYASEEEGDHGFTQIMNICVDKSTVPYYGRNSSKRYIRGKPIRFGYTQWVLPKDNGYIVQFEPYCGADMKMKAELGLGGSVVMDLLAELPEELPFKLYIDNFFTVLPLLKALSEKGIGAACTIRTNRVEKCPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TKZ8</accession>
    <name>A0A433TKZ8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ELMO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_009980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000295">
        <property type="protein sequence ID" value="RUS82242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TKZ8"/>
    <dbReference type="STRING" id="188477.A0A433TKZ8"/>
    <dbReference type="OrthoDB" id="67155at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF51">
        <property type="entry name" value="LD01482P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="ELMO" evidence="2">
        <location>
            <begin position="122"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS82242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="292" mass="34695" checksum="AF34E111E1C1609F" modified="2019-05-08" version="1" fragment="single">FSTELFYKWWTKLYFVWLRPMVKLLFKWVTGQCELLRITYSNSCQADRVKRIGKFIHNDKSVLLCFIIFLFFFWFSKFKLFFSPLRFQISLKDSLQRISAYNRLIVQAENLRKTRFSSDNDDHEEKLNTLWRLYNADCLALPCRVGHHWTEIGFQGDDPATDFRGMGLLGLDQLIFFADIYPQQAMHVLSQSRHPQFGFSFAIVGINMTEMCVTLLKKRMFGSYIYSFEKEGSDLTDFHKIYCHIFHGFAQHWFAERPESIMEFGRVRADYLQKVEIMLGSDETVLLSEFQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TLQ8</accession>
    <name>A0A433TLQ8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_009757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000284">
        <property type="protein sequence ID" value="RUS82494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TLQ8"/>
    <dbReference type="STRING" id="188477.A0A433TLQ8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS82494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="170" mass="19317" checksum="457E809E65AFCA75" modified="2019-05-08" version="1" fragment="single">LVGWLIGWLVGWLVGLFGWLVGWLVGWLVGWLVGWLVGWLVGWLVGFLVGWLVGWLVGLLVGWLVGWLVGWLVGWLVGWLVGWLVSWLVGCLLVGWLDNWLVGWLVGWLVGLVSWLVGWLVGWLVGWLVGGWLVGWLVGWLVGWLVGWLIGWLVGWLVVWLPRWLTGWLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TML3</accession>
    <name>A0A433TML3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_009403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000269">
        <property type="protein sequence ID" value="RUS82827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TML3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS82827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="215" mass="23649" checksum="12B5106965B687DF" modified="2019-05-08" version="1" fragment="single">HNKYTPTQTDNSIRKEESQPVLDKKSSQSASNMKSLPSQPNILSSAQNTHFRESSPTQSDLNKKSSLTQSNLNRKSSATQPNPQSSTTQPNQQTNLNRKSSATQPNLNGKPSVTQPNLNRKSSPTQSNLNRKSSPTQSNLNRKSSVTQPNPQTNPQPSTIQPNLNRKSSLQTQPNLIRKPSPTKSNLNRKPSPTQSNVDKKSLPALSNLNRKPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TNC1</accession>
    <name>A0A433TNC1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha-ketoglutarate-dependent dioxygenase AlkB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_009173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000259">
        <property type="protein sequence ID" value="RUS83087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TNC1"/>
    <dbReference type="STRING" id="188477.A0A433TNC1"/>
    <dbReference type="OrthoDB" id="28127at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032870">
        <property type="entry name" value="ALKBH7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052:SF0">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052">
        <property type="entry name" value="SPERMATOGENESIS ASSOCIATED 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-ketoglutarate-dependent dioxygenase AlkB-like" evidence="2">
        <location>
            <begin position="227"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS83087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="330" mass="39098" checksum="86840B80FF904DDF" modified="2019-05-08" version="1">MKLWTRNCQKSTGLQIIMETYQRINKLLFDIFKPLSRKYQSISNPRQTMSPRHNTCLSLISHNDPFVLRHQNHAVQIQKSNFSTWADTNPHRITSYALQQKLSCSELFLKRFKKVSKRNYSTTPDESQQSKNYLDVKDDRLRDILSSDMIVKTDFLNEKEEESLFVEVEKYMRRLRYEFDHWDNAIHGYRETEKREWNEQNMMILERVKSLAFTSNVAPLAYVHVLDIAKDGYIKPHVDAVRFCGDTITGMCLLSSCVMRLALENDSTKFADVYLPRRSLYIMRGKARYEFTHEVLKDDQSYFKNQYVPRDRRISIICRNEPTTAQNSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TNY0</accession>
    <name>A0A433TNY0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Bile salt export pump</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EGW08_008955</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">EC2010</strain>
            <tissue evidence="16">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000250">
        <property type="protein sequence ID" value="RUS83275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A433TNY0"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000009">
        <property type="entry name" value="ABC transporter B family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000205">
        <property type="entry name" value="ABC transporter B family member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000479">
        <property type="entry name" value="Multidrug resistance protein 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="340"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="776"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="819"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="901"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="924"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1001"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1036"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="107"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="439"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="778"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="1100"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="35"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RUS83275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1349" mass="148285" checksum="70BB399D12CF6701" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TSY8</accession>
    <name>A0A433TSY8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_007557</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000197">
        <property type="protein sequence ID" value="RUS84687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TSY8"/>
    <dbReference type="STRING" id="188477.A0A433TSY8"/>
    <dbReference type="OrthoDB" id="9894375at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="74"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS84687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="481" mass="53919" checksum="EAD244C1A66DBF52" modified="2019-05-08" version="1">MFAVGELIHRENTSGDESSFTHTNNTNSTTLTNSDSLTASPNTSHGGCTYKDFSSSKFGLNYAVISVGVVLILQNSLLIFVIARNARLHTNTNLLVASLAVTDVLMGVQCFVVGITGLGVGARDWLATLGADLHVFDIMILSINLALVGVSLLHVVCLAVDRYLFLLWPFRYRNSVTRARIMALAAVIWTLGVLYALLPLVLFNDSHHRRSCLLSEAPVSFGYVPIGCVYLVCLVVVTYCTRGMVKLARQHRRGRVRKHTRNLGSKLHSAPDKSEVVLTVYRIANNNLPNMVEKDIYTRPDNVEQTDVDLNFSSPEVPITNKSQREFKDITSHFANVKGSHANKRILDNNSKNQLDSTTMEVFKVSEDVNNQQNYQHNTVLDGKTRLFNKSNIKILKFVLVVFGTFLAFTFPEIALLSLIKLFHLSLFNGDEFAFDVLHFMITINSGMNFLTITYMNKDFRRALLKSLPFCTFCFRTRNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TUG8</accession>
    <name>A0A433TUG8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_007015</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000178">
        <property type="protein sequence ID" value="RUS85189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TUG8"/>
    <dbReference type="STRING" id="188477.A0A433TUG8"/>
    <dbReference type="OrthoDB" id="199913at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF173">
        <property type="entry name" value="LIPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019056438" description="Lipase domain-containing protein" evidence="5">
        <location>
            <begin position="23"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="6">
        <location>
            <begin position="23"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS85189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="501" mass="55016" checksum="08095F1EBAEB5110" modified="2019-05-08" version="1">MAFALTVVLNLAALSVLRPVCGKEVCYDVVGCFNNNPPFDNAGNELPASPVEVGTKFHLYTIEKRDIATSLFYTQPVSITNSNFRSDRPTKIVIHGLNKSEKSEWIINMRKALLLRGDYNVIVVHWHNGARLTNYAKASANVRLVATQIKVLLNLIQRTVGLQLEDVHIIGHSLGAHVSGYVGTLMGDQIGRITGLDPADPNFEDLPYVIRLDPTDARFVDVIHTGARDYANIAGLGLMQQSGHIDFYVNGGEKQNGCEDGIQGLISGVINAVTGKSDKSLLSSAGKGASCSHSRAHAIFIESMNSTCKFTSFPCDSYEKFLRGECYGCGSTGCSEVGWHATDHPTAKGKHYLMTNPDYPYCGAFYYNLLIEVEPGQDESKADISVQLRSKTGSRSRKISLMGNEDAKLGRQDINMPILLDKPLRELGQEEILIAITYKIKPSSWSLTTFWKQKSLKIEAVTLTEVATGIRLSSPRRVLSLNDKIGNVITLRREIYNGLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TUI4</accession>
    <name>A0A433TUI4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Medium-chain acyl-CoA ligase ACSF2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_007004</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a medium-chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:48340"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:59558"/>
            <dbReference type="ChEBI" id="CHEBI:90546"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>octanoate + ATP + CoA = octanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33631"/>
            <dbReference type="ChEBI" id="CHEBI:25646"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000177">
        <property type="protein sequence ID" value="RUS85243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TUI4"/>
    <dbReference type="STRING" id="188477.A0A433TUI4"/>
    <dbReference type="OrthoDB" id="6132398at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF5">
        <property type="entry name" value="MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="8">
        <location>
            <begin position="418"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS85243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="514" mass="56995" checksum="FF3BBD0FC947C203" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TXX8</accession>
    <name>A0A433TXX8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Maspardin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_005768</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000138">
        <property type="protein sequence ID" value="RUS86453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TXX8"/>
    <dbReference type="STRING" id="188477.A0A433TXX8"/>
    <dbReference type="OrthoDB" id="10264550at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026151">
        <property type="entry name" value="Maspardin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15913">
        <property type="entry name" value="ACID CLUSTER PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15913:SF0">
        <property type="entry name" value="MASPARDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="5">
        <location>
            <begin position="82"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS86453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="304" mass="34453" checksum="78B5A8FC141EB91B" modified="2019-05-08" version="1">MSDIAKSQEYMSFRSTIPQRKVVVDDDNTKEWTLYEAGPKTVKSPLICFPPASGTADVYFRQILGLSALGYRVIAVEYPMYWTMKEFVEGFRKLMDHLGLDKVHIFGASLGGFLAQKFAEYTSRSPRVGSLVLCNSFYDTSIFQQTSSAPTFWMMPAVVLKKMVMGSFHKAETESHIADSIDFMVERLDSMSQQALASRLTLNCMNCYVEPQKLRDVDVTLMDVFDECALSLNVREEMCKCYPEAKRAHLKSGGNFPYLSRSVEVNVFLQIHLRKYDLSSLRARELTEEEMAMLADSDAGTDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TYB3</accession>
    <name>A0A433TYB3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_005738</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000137">
        <property type="protein sequence ID" value="RUS86488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TYB3"/>
    <dbReference type="OrthoDB" id="6157089at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019103305" description="Cadherin domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="3">
        <location>
            <begin position="139"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS86488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="230" mass="25150" checksum="C7384AA4CCF59668" modified="2019-05-08" version="1" fragment="single">MGSIRRNFVRLWIFLMLGSLMIHAAEIMTTNVVTLNENQRTDLTVADVQCTDGTNMVLSGDISPTAFCTFCFVVEPNNIATGTYKINFYPSVADLTFSQVPEYDITLTCEDLDNTTNTVTEVLEIRITPNSAPIFTNGLSDQQTISSTKDKVAGEALFTVAATDPNSDEIYYTLSQTDPTSNNFQIGLTDGIVSAVNDLNTQCTQEIDLYITITDGSIQVGPQVIDVTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TYJ4</accession>
    <name>A0A433TYJ4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_005603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000132">
        <property type="protein sequence ID" value="RUS86654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TYJ4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS86654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="158" mass="17037" checksum="765B0F0254CD41E9" modified="2019-05-08" version="1">MPLTAPWLATCPQGNSTTLQACPADLTPTTTALPCLLHTWGRWICRHRTSPTPQATTSALSRTTQCTAPRPESTDPCTGTSQTSPGKSRTTTMFITIVYLLAPSKMLRATTLSTQTGSQKGPPCDDQNPSSLSKLHCMIDGHHLDTYNGSVKKFFTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TZK4</accession>
    <name>A0A433TZK4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_005313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000124">
        <property type="protein sequence ID" value="RUS86908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TZK4"/>
    <dbReference type="OrthoDB" id="10527932at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019249886" evidence="2">
        <location>
            <begin position="35"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS86908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="152" mass="17663" checksum="7DA25575B9FFEF78" modified="2019-05-08" version="1" fragment="single">MRMRVCLPGHASSHTATVLLLIACLSYLLESVVSQTCEDKCRNTFNYYNSFLQSPVLVQYYYQSCLSRCYVPVGGNQVYPGSQIWPTPPASTAAPLPWWQQIYQQNPQPQQPTWQQPQQQPQQPTWQQPQQPQQPTWQQPQQYIQPQLQPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U119</accession>
    <name>A0A433U119_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_004813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000111">
        <property type="protein sequence ID" value="RUS87438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U119"/>
    <dbReference type="STRING" id="188477.A0A433U119"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="48"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS87438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="192" mass="21806" checksum="446415BB7CE2D603" modified="2019-05-08" version="1" fragment="single">SIFHNLCYLTLIHQEKLVAIQDDLFLRLPRESTASSFNDQNSKSINININMLVTGALETAFCDFDEHIAREKNMFNISGGCAAVVVLIMMDRVYVAHAGDCRAVAYIGNENILMAREFTPMTDAERIQAVANLKPDLTYSFFSDNYFLKPLSKKDLGTQVYCRLPHRHGWYYKEVTEEDLSKPSLVTGHGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U4L6</accession>
    <name>A0A433U4L6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">heparosan-N-sulfate-glucuronate 5-epimerase</fullName>
            <ecNumber evidence="6">5.1.3.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EGW08_003543</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">EC2010</strain>
            <tissue evidence="15">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[heparosan-N-sulfate](n) = [heparan-N-sulfate](n)</text>
            <dbReference type="Rhea" id="RHEA:20197"/>
            <dbReference type="Rhea" id="RHEA-COMP:9556"/>
            <dbReference type="Rhea" id="RHEA-COMP:9557"/>
            <dbReference type="ChEBI" id="CHEBI:58041"/>
            <dbReference type="ChEBI" id="CHEBI:58287"/>
            <dbReference type="EC" id="5.1.3.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Glycan metabolism; heparan sulfate biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; heparin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Endomembrane system</location>
            <topology evidence="12">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the D-glucuronyl C5-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.17" evidence="6"/>
    <dbReference type="EMBL" id="RQTK01000075">
        <property type="protein sequence ID" value="RUS88728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U4L6"/>
    <dbReference type="STRING" id="188477.A0A433U4L6"/>
    <dbReference type="OrthoDB" id="5914444at2759"/>
    <dbReference type="UniPathway" id="UPA00862"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047464">
        <property type="term" value="F:heparosan-N-sulfate-glucuronate 5-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015012">
        <property type="term" value="P:heparan sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030210">
        <property type="term" value="P:heparin proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010598">
        <property type="entry name" value="C5-epim_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039721">
        <property type="entry name" value="C5-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059154">
        <property type="entry name" value="Glce_b_sandwich"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13174">
        <property type="entry name" value="D-GLUCURONYL C5-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13174:SF3">
        <property type="entry name" value="D-GLUCURONYL C5-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06662">
        <property type="entry name" value="C5-epim_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21174">
        <property type="entry name" value="Glce_b_sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="D-glucuronyl C5-epimerase beta-sandwich" evidence="14">
        <location>
            <begin position="234"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="D-glucuronyl C5-epimerase C-terminal" evidence="13">
        <location>
            <begin position="413"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF21174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RUS88728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="621" mass="68925" checksum="5208B14702433EBF" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U7U4</accession>
    <name>A0A433U7U4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Paired box protein Pax-6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EGW08_002326</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">EC2010</strain>
            <tissue evidence="15">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000045">
        <property type="protein sequence ID" value="RUS89885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U7U4"/>
    <dbReference type="STRING" id="188477.A0A433U7U4"/>
    <dbReference type="OrthoDB" id="3225452at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090596">
        <property type="term" value="P:sensory organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00131">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000003">
        <property type="entry name" value="Paired box protein Pax-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000069">
        <property type="entry name" value="Paired box protein Pax-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000516">
        <property type="entry name" value="Transcription factor Toy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043182">
        <property type="entry name" value="PAIRED_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF41">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00027">
        <property type="entry name" value="PAIREDBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00351">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00034">
        <property type="entry name" value="PAIRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="9 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0563">Paired box</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paired" evidence="14">
        <location>
            <begin position="161"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="410"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="412"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="342"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="615"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RUS89885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="643" mass="70402" checksum="902FD532B5CC6675" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U8M4</accession>
    <name>A0A433U8M4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EGW08_002105</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">EC2010</strain>
            <tissue evidence="16">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000039">
        <property type="protein sequence ID" value="RUS90138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U8M4"/>
    <dbReference type="STRING" id="188477.A0A433U8M4"/>
    <dbReference type="OrthoDB" id="10072614at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306:SF6">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="14">
        <location>
            <begin position="64"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="domain" description="SMC hinge" evidence="15">
        <location>
            <begin position="518"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="312"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="382"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="675"/>
            <end position="863"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF06470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RUS90138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1116" mass="128665" checksum="55DCD952FBDDCB4D" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U902</accession>
    <name>A0A433U902_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_001978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000036">
        <property type="protein sequence ID" value="RUS90289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U902"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS90289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="145" mass="16055" checksum="7FE7986C428E952D" modified="2019-05-08" version="1" fragment="single">VTSARAQHLRNKNVAKLESRRGEPEKEKAGAKDREKDGEKDTTDGTVKTVKKPKITVPDPDEMARPGSSLRLTRINIPDLEPIVTSRTPRRIENEVYDSPGRHSLKSCSRPTTPALPGQAQEEAQEPVQEPGKDQQAKGKGKQDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UAZ7</accession>
    <name>A0A433UAZ7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_001222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000020">
        <property type="protein sequence ID" value="RUS91005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UAZ7"/>
    <dbReference type="OrthoDB" id="6148554at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS91005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="183" mass="20284" checksum="63F43F35B2AC5571" modified="2019-05-08" version="1">MPSQSMAHLLPPAGITYPASETFRNYLVRPPAKKQQDKEVIVCCERMPPSGPCCRSDVRCKVIDGDQVFTAKLCPDSSDIVTNFCVENDCRPRPPLTQPGLLCCTSCEDKCPPPCPKVCPTPGLRTCKTFTFRQPCPPCPNPCSKPRPFSRPCRPPRASSASCGNRPRLVKESITSHCYTYQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UB90</accession>
    <name>A0A433UB90_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_001132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000018">
        <property type="protein sequence ID" value="RUS91107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UB90"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS91107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="90" mass="10139" checksum="7F5A286A76EC0409" modified="2019-05-08" version="1" fragment="single">AKRVVVDPPIRDKIAPKCGIDSAMNSTTTIISVREIIRLNVKSETNRGLHMWLMTITKPKKRCRVIRISTIYCIGPPERLSRILSSALIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UE55</accession>
    <name>A0A433UE55_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF389 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_000130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000002">
        <property type="protein sequence ID" value="RUS92106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UE55"/>
    <dbReference type="STRING" id="188477.A0A433UE55"/>
    <dbReference type="OrthoDB" id="543859at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005240">
        <property type="entry name" value="DUF389"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20992">
        <property type="entry name" value="AT15442P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20992:SF9">
        <property type="entry name" value="AT15442P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04087">
        <property type="entry name" value="DUF389"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="434"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="518"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="18"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="635"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="765"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="585"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="639"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="651"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="765"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS92106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="800" mass="88441" checksum="FBF655337F40286E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UEG2</accession>
    <name>A0A433UEG2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_000147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000002">
        <property type="protein sequence ID" value="RUS92123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UEG2"/>
    <dbReference type="STRING" id="188477.A0A433UEG2"/>
    <dbReference type="OrthoDB" id="10064757at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS92123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="601" mass="69447" checksum="02383ED3C5F5CC2A" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z454</accession>
    <name>A0A3S0Z454_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_023276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001902">
        <property type="protein sequence ID" value="RUS68963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z454"/>
    <dbReference type="OrthoDB" id="6211549at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018787204" evidence="1">
        <location>
            <begin position="23"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS68963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="161" mass="18836" checksum="C812AF954E822033" modified="2019-04-10" version="1">MKEKRNEWIQLFLALLFLPAVALQKLFHQFKLGLEENNKSNRVDLPGIEVGEFRSKQVISQIQVKVALTDGKCHVKNGDAELSAKCNRVLSDMNAFQREFLTHGPEANQNMVFTEVILRDETGCEERRAYFEPDKERDSLIRFFWEKMKDAVSTLHRFKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z6G3</accession>
    <name>A0A3S0Z6G3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SRR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_020520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SRR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001170">
        <property type="protein sequence ID" value="RUS71723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z6G3"/>
    <dbReference type="STRING" id="188477.A0A3S0Z6G3"/>
    <dbReference type="OrthoDB" id="551431at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
        <property type="entry name" value="SRR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040044">
        <property type="entry name" value="SRR1L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28626">
        <property type="entry name" value="SRR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28626:SF3">
        <property type="entry name" value="SRR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
        <property type="entry name" value="SRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRR1-like" evidence="2">
        <location>
            <begin position="11"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS71723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="110" mass="12393" checksum="9FE6E975CE7FF6EC" modified="2019-04-10" version="1" fragment="single">NNINGQTNARRERKVSILSFGVGNFTSCLIARYQLAFLLALRDKLEKQCSACELFDPVFTTHEKSVLAAYKCQVPAHNEEGKHVCLSPTIVFMPHCGKALYNNFLWKNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZBA7</accession>
    <name>A0A3S0ZBA7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_018453</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="RQTK01000900">
        <property type="protein sequence ID" value="RUS73783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZBA7"/>
    <dbReference type="STRING" id="188477.A0A3S0ZBA7"/>
    <dbReference type="OrthoDB" id="6147159at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018381364" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="23"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="38"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS73783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="246" mass="26822" checksum="A70B8F014E36083E" modified="2019-04-10" version="1" fragment="single">MKRLNGIHVLMVVSILIGPTLSKSRHVRSTVDDPDYVTVSTKYGDIKGRNYNVSDSLDLNVFLGIPYAKPPVGDLRLARPESVQPWTPNVYNATQHGAKCVQRILTGDPELEGVPFSEDCLFIDIYATRERVGARAKQPVMMYLHPGGFYGGTGAKYNFTNLALKGVVVVTVNFRLDMFGFLSTQDDVIPGNFGLLDAALALDFVKEIIGNFGGNPEDITLFGASSGAAMVSIFTLSPLTRGKFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZC94</accession>
    <name>A0A3S0ZC94_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Leucine-rich repeat-containing protein 68</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_020590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPP1R37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001180">
        <property type="protein sequence ID" value="RUS71650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZC94"/>
    <dbReference type="OrthoDB" id="10034042at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051279">
        <property type="entry name" value="PP1-Reg/Actin-Interact_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112">
        <property type="entry name" value="LEUCINE-RICH REPEAT, ISOFORM F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112:SF9">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="95"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="525"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="594"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="635"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="858"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="954"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1072"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="537"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="552"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="594"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="652"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="858"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="960"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1011"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1072"/>
            <end position="1087"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS71650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1097" mass="119224" checksum="2CD4349FB1C2545F" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZG89</accession>
    <name>A0A3S0ZG89_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_018101</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000862">
        <property type="protein sequence ID" value="RUS74146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZG89"/>
    <dbReference type="STRING" id="188477.A0A3S0ZG89"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09823">
        <property type="entry name" value="peroxinectin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.640.10:FF:000003">
        <property type="entry name" value="chorion peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF4">
        <property type="entry name" value="CHORION PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018690346" description="Peroxidase" evidence="7">
        <location>
            <begin position="23"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="44"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="78"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS74146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="668" mass="74307" checksum="BD0DF980C82303A5" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZIR8</accession>
    <name>A0A3S0ZIR8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AMP deaminase</fullName>
            <ecNumber evidence="4">3.5.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_016513</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.6" evidence="4"/>
    <dbReference type="EMBL" id="RQTK01000716">
        <property type="protein sequence ID" value="RUS75731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZIR8"/>
    <dbReference type="STRING" id="188477.A0A3S0ZIR8"/>
    <dbReference type="OrthoDB" id="1723809at2759"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01319">
        <property type="entry name" value="AMPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.20:FF:000001">
        <property type="entry name" value="AMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01429">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF0">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="94"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS75731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="771" mass="87702" checksum="ED532147EF284667" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZL56</accession>
    <name>A0A3S0ZL56_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_010751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000335">
        <property type="protein sequence ID" value="RUS81495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZL56"/>
    <dbReference type="OrthoDB" id="6162001at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS81495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="231" mass="26173" checksum="BE3686E3054B7169" modified="2019-04-10" version="1" fragment="single">MEANDQTEEEVCSRLEDGRDYLLARAKFWKEKGPLPPRPPTTSLGLRLQRERDMQSRMTEERERESRAEGALSRQVTQVTQVTQVSKTDGRESQAGADKSRTGSSEQKQKDMEKQKAEPRNEGSRSEKLDTKQQVESRDQYGKGQQAADNDKHVSRDDQGQGRQVLSARKKNGDGEDENNAPSAVQSNGDNPQPISGGQGNGETPKEQQQQQQQQQQQQQQQQQQQQQRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZLF1</accession>
    <name>A0A3S0ZLF1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_022134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001490">
        <property type="protein sequence ID" value="RUS70109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZLF1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS70109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="340" mass="39459" checksum="2C0DB976D5E5D4B0" modified="2019-04-10" version="1">MWYDHGSDEDLDTEDGRRESRKEKRRDSRRDRRRESQDSRRESRGSRRSTQDSRRSSQNSQRDSQEIPRESQESHRSSKGGAAMEMLDETYHDPPSGKAAEKRVSEVKKPETLPDEGEHEQEKVPDEKLSAHERKAMPEDESHVESVSSKTHHQDTFGDWESEKGEPMTMTVDESDRRSSFRKKKRQKDDDASDTETLTRHTSETGSDAKSKRKRSDTGEKPRKYVPIEFGVWSLVEKRLVCEHPRLGRLGEPPQIRAQQNVPDWAERRLPCEVLYEDEIYTVCVEWKDEVEDDVSSLQMESSVQETPQPMPAPRSTITRHSHASGVPRESAKKSFKKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZNB6</accession>
    <name>A0A3S0ZNB6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_020809</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001213">
        <property type="protein sequence ID" value="RUS71426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZNB6"/>
    <dbReference type="OrthoDB" id="6435476at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS71426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="31477" checksum="67E0596F1F5273A2" modified="2019-04-10" version="1" fragment="single">EDSKESANDSTLEDTYDGRYDEFQLKQQSPTAGGDADPLSSVDLVELKPAAKNSDKLLVSKLKVGGEEQRDSASTSSGRPLRDRRSLCGVLDNSFFKNWLFLLMLLSTVHGALMMYSLAYIPTLAASQGLDKNSGTRLLTIAGGVNLVGMPLQGIILDTNRILPSQYIALAQIAVGTVCHLIRYLTSFPALVVIAVAQGLLGGSRISLIPVVAVEFVDVHSAGKVVGFNALVGTISLAMHHPFLGFITDRTGSFNASFHYVGAGLYLSSFLFLLSPMVRRKQVARPGNMDISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZPA0</accession>
    <name>A0A3S0ZPA0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_008555</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000234">
        <property type="protein sequence ID" value="RUS83707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZPA0"/>
    <dbReference type="STRING" id="188477.A0A3S0ZPA0"/>
    <dbReference type="OrthoDB" id="10039134at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001707">
        <property type="term" value="P:mesoderm formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11390">
        <property type="entry name" value="bHLH_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040259">
        <property type="entry name" value="Mesogenin/MesP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20937">
        <property type="entry name" value="IP14615P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20937:SF3">
        <property type="entry name" value="IP14615P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="150"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="127"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="276"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="301"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="352"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS83707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="397" mass="45471" checksum="EB7C536555F49D71" modified="2019-04-10" version="1">MDKSTSVNLKSQSIPDGELVCFASYSDGYPKDSVTKTYSFFDTGARDFRDSKPVSISSNTYSSCCSTSSRSMSCSGSPDISFPSSFMDFSSPCILYPGSQYNRSYPVDSGAHLHSDAYSHAAFSPFAQSPESEQDSYSNRKRKAPKSYEMSRIGATERERTRMHMLNDAFDELRKVVPKSNLSEHQKLSKIATLRLAIHYISALGSTLKATGAEIKLVKDTGVCDRRGKRRGRAGRRRKLPDSLQHQQFPCPSVTMARNEMPVGAEYYSQYIQYHHHSHHHHHQPETQQPLEQHHHHPHHQQQNQQQQQQQQQSLQHQHHQQHHALGLSMQGQHNNSRSYQMCPTSYHLSNQHTQQQQQQQRQSNYQVPRGCQESFERERPAFGSNRQQMQHLLCSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZQL1</accession>
    <name>A0A3S0ZQL1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GAIN-B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_007775</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000204">
        <property type="protein sequence ID" value="RUS84479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZQL1"/>
    <dbReference type="STRING" id="188477.A0A3S0ZQL1"/>
    <dbReference type="OrthoDB" id="1100386at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032471">
        <property type="entry name" value="AGRL2-4_GAIN_subdom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16489">
        <property type="entry name" value="GAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="GAIN-B" evidence="7">
        <location>
            <begin position="75"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="130"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS84479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="214" mass="23049" checksum="13E0E10CF4E415F3" modified="2019-04-10" version="1" fragment="single">AVVWTSSRLLAKSHQTSWKELSPRDRRRAATSLVTQLEKTGFELADSLAVGQSSVTLDRNVVVKATRLDTQTHQTDLTFPAHDDLDLQAPWQGNGNSITISSTSLKSAGHTGPLSVVFMMYNNLEDLMEPQQNEASPTSSTDDSQPVYDTDIISGNSVSSRGAGSDAAGGGTDDKTVPATPELVVNSRIISASMGSSRLRRLLPEPVRFTLKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZQM9</accession>
    <name>A0A3S0ZQM9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_008665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000239">
        <property type="protein sequence ID" value="RUS83559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZQM9"/>
    <dbReference type="OrthoDB" id="8194222at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS83559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="214" mass="23884" checksum="43F7320C50B7BF28" modified="2019-04-10" version="1">MQSSPSSTNSEPLSTEAAPKTAKRKGKGKKEKTTSAESSTLRPSQEDQQPSTSKQRVPREQPATSTADPLYLCIMCHEPYVEPPTEDWTMCMKRHERAHEACADHAVSHLARSRPAWTSLGRLPLVLSTVNLRVERSQHGTVTQQLFNLLKSCLWCRVPLPLTSFFVSWYNVSKTIGRFKRDLNLSEEGTEVGYAGPEILCKAADTFSVEAHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZU04</accession>
    <name>A0A3S0ZU04_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_016980</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000757">
        <property type="protein sequence ID" value="RUS75265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZU04"/>
    <dbReference type="STRING" id="188477.A0A3S0ZU04"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052801">
        <property type="entry name" value="Ankyrin-EF-hand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24127">
        <property type="entry name" value="ANKYRIN REPEAT AND EF-HAND DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24127:SF1">
        <property type="entry name" value="ANKYRIN REPEAT AND EF-HAND DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="47"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="80"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="184"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="250"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="366"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="519"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="552"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="585"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="649"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="651"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS75265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="765" mass="84440" checksum="B05B2A7E2E338277" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZXG9</accession>
    <name>A0A3S0ZXG9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_003117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000065">
        <property type="protein sequence ID" value="RUS89109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZXG9"/>
    <dbReference type="STRING" id="188477.A0A3S0ZXG9"/>
    <dbReference type="OrthoDB" id="6130158at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS89109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="28070" checksum="F5941D22C1B3D3BD" modified="2019-04-10" version="1">MCSLPPLDNTCLSLIRPLKASPNEPPLKLKICHGNRTFPVTLRIADNENGARISMRHLAEVVLHQTGIIPREQRYCFRGITWENPDLGPWSPGLRDLGLKNGDKVQLVSFHHSVPDWESVSALACLEKRFSCIVHQIHDAFHRLNGVHQGYIELGNQLMALAEIRLAVDNAKDKLLILIKDLNALNLDYRNYDCQARRREAVDSAQRQVDKCGSLSSSIFHKLAQSQSLSRSGPLYAGDPLRAMKKPGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZXH1</accession>
    <name>A0A3S0ZXH1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA polymerase II subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_006767</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase epsilon subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000168">
        <property type="protein sequence ID" value="RUS85491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZXH1"/>
    <dbReference type="STRING" id="188477.A0A3S0ZXH1"/>
    <dbReference type="OrthoDB" id="10254730at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016266">
        <property type="entry name" value="POLE2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="7">
        <location>
            <begin position="75"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS85491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="353" mass="39046" checksum="1ABA147C83E18309" modified="2019-04-10" version="1" fragment="single">FQAGLVTENSFVLAEGWYDDGIFHVEAFGLPPPEKAETTRSYFGNINFFGGPSPIQVKGSSRLAKVEAENTEVMFVILSDVWLDDSKVMEKLNTLFMGYSAFPPTAFILCGNFLSSPKVLSHAKTLQECFRELGSMLSNYPDLISTSQFVFVPGPNDPVHSTILPRPTIPNSIIEAFMKKVPGAVFTSNPCRIQYCTQEIVVFREDIVTKMCRNCIRFPKEGNIPSHFAKSLMSQAHLCPLPLHVSPIYWAYDSSLRVYPLPDLIITADKYDPFVTSAMGTTIVNPGSFSRTNFGFKVYCPATRDVQDSQVSDPGDATFNASTSQVSDLSLLQGVESQSQSQVLDDPEVETIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A0V8</accession>
    <name>A0A3S1A0V8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_000668</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000009">
        <property type="protein sequence ID" value="RUS91553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A0V8"/>
    <dbReference type="STRING" id="188477.A0A3S1A0V8"/>
    <dbReference type="OrthoDB" id="6143781at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15203">
        <property type="entry name" value="7tmA_NPYR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235:SF12">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235">
        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="37"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS91553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="321" mass="36406" checksum="63EE6FD63FB8401B" modified="2019-04-10" version="1" fragment="single">MLDIVKQYTNQTFWFSASTVIALVVSYCTIIILGLFGNILVIVVISRKKSLRGSRNMYILNLSICDVVMCSICMPFSLAKLSLKKWTLGLAMCRTMSALATIDVFVSTLTIVAISVDRYMSIVHLSQLTSRQVVLALLTIWVVAISLSTPLFCFYKIDTLKMYEHTFVQQCIDAWPSERFREIYTTAVMLVQYLTPASVISYLHGRICRFLQARHEERPGFESQMAEKTRNDLRRHRTNMVLLTAVALVFSLTWLPLTLLNITADLAHEIFQESHYNLIHAISLLVAMSSSAINPIIYGWFNSNFRCAFLEILGLSSGEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A1A5</accession>
    <name>A0A3S1A1A5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_012043</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000406">
        <property type="protein sequence ID" value="RUS80186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A1A5"/>
    <dbReference type="STRING" id="188477.A0A3S1A1A5"/>
    <dbReference type="OrthoDB" id="2014092at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS80186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="12427" checksum="5602D30A12953831" modified="2019-04-10" version="1" fragment="single">QIGSLSCISYGTWMLTHKSNIIDNVTDVFLDPYVLLCVVGAVVFIVAFIGCLGALRENIYLLKIVRLFIHHICQFGCCGVSMSNDGYLDWQENQYFNCSDANPSMHRCSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A1F4</accession>
    <name>A0A3S1A1F4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_004029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000090">
        <property type="protein sequence ID" value="RUS88197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A1F4"/>
    <dbReference type="STRING" id="188477.A0A3S1A1F4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS88197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="148" mass="16805" checksum="D2B0F6CE02278EAB" modified="2019-04-10" version="1" fragment="single">PHKFKRDAPHKLKRDATHKLKHDATHRLYGDALHKLKGDAGVFEFRDAPHKLKGGAPHKLKRDAPHKLKGCAPHKLKRDTPHKLKRDAEHKLKRDAPHKLKGDATHKLKGDAPHKLKRDAPHKLKGDAPHKLKRDAPHKLKGDAPHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A1N1</accession>
    <name>A0A3S1A1N1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">TPX2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_003903</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPX2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000086">
        <property type="protein sequence ID" value="RUS88332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A1N1"/>
    <dbReference type="STRING" id="188477.A0A3S1A1N1"/>
    <dbReference type="OrthoDB" id="1684416at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060236">
        <property type="term" value="P:regulation of mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027329">
        <property type="entry name" value="TPX2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027330">
        <property type="entry name" value="TPX2_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009675">
        <property type="entry name" value="TPX2_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14326">
        <property type="entry name" value="TARGETING PROTEIN FOR XKLP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14326:SF44">
        <property type="entry name" value="TARGETING PROTEIN FOR XKLP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06886">
        <property type="entry name" value="TPX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12214">
        <property type="entry name" value="TPX2_importin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPX2 central" evidence="10">
        <location>
            <begin position="321"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="TPX2 C-terminal" evidence="9">
        <location>
            <begin position="616"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="27"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="212"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="287"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="461"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="531"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="683"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="634"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="234"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="500"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS88332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="708" mass="79941" checksum="CFABD5680851CA5F" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A2N8</accession>
    <name>A0A3S1A2N8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_011114</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000354">
        <property type="protein sequence ID" value="RUS81128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A2N8"/>
    <dbReference type="OrthoDB" id="6144478at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="16"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="299"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS81128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="324" mass="36349" checksum="0F545B24951CE42B" modified="2019-04-10" version="1">MKIYLFVAVEFSAVVLNLAFTIVVWTRTSVGEFLRVILMGLVFVNLMTNAQCMALDLSMAVGIYLGWPICFSQFVIAPFCIYATLLLVTVINTERIVAIKWPLSYQTYFTKVKATLVLFVIFISAMALTLVGLPDLLRQYERSVSVCLPTDLYPRRYATYLISATCSFLLLVVLLSFMVNVRVLLAFKKHKLARVNQAPSHATRKMTRSALVASRIAFASAFLYTWSIGFMVTFLFWMSIYHCDDMCLSEGNFSVAAALVQLMLTFQDPLVFFISIVKWSSLKRRVLRLCGAFNGSNQVAPSSSHLQGSSQPQTSNLALSNRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A2X4</accession>
    <name>A0A3S1A2X4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipocalin/cytosolic fatty-acid binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_002991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000061">
        <property type="protein sequence ID" value="RUS89248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A2X4"/>
    <dbReference type="OrthoDB" id="354351at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00742">
        <property type="entry name" value="FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031259">
        <property type="entry name" value="ILBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11955">
        <property type="entry name" value="FATTY ACID BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS89248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="16141" checksum="BD7EC8E90A23DBBC" modified="2019-04-10" version="1">MEAIFGTWKNKKGSEENMTAFMDACKIPEAARQVMLDREYEISYTKGATDKSMKVSVKVTNDSKLPEKSYEYELGKEFECDDIDGQHFKCTITWDGSKFVENYVDDKGTKMAIQREITPDGIMKFAMICLGVTASSTWEKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A4R2</accession>
    <name>A0A3S1A4R2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytoplasmic phosphatidylinositol transfer protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Retinal degeneration B homolog beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_001682</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PtdIns transfer protein family. PI transfer class IIB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000029">
        <property type="protein sequence ID" value="RUS90594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A4R2"/>
    <dbReference type="STRING" id="188477.A0A3S1A4R2"/>
    <dbReference type="OrthoDB" id="10053061at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000011">
        <property type="entry name" value="cytoplasmic phosphatidylinositol transfer protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001666">
        <property type="entry name" value="PI_transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055261">
        <property type="entry name" value="PI_transfer_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10658:SF54">
        <property type="entry name" value="CYTOPLASMIC PHOSPHATIDYLINOSITOL TRANSFER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10658">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02121">
        <property type="entry name" value="IP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00391">
        <property type="entry name" value="PITRANSFER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="3" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Phosphatidylinositol transfer protein N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00061154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00068698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00082927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS90594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="255" mass="29888" checksum="ECF50DC22CC091F0" modified="2019-04-10" version="1">MLLKEYRICMPISVDEYRIGQLYMIAKHSSEQSESGQGVEVVKNEECSDPVHGSGRYTEKRVHLSSRLPSWIRSLIPKVFYVTEKAWNYFPYTITEYTCSFMPRFSIHIETRYEDNAGTTENCVDLTPKELELRTVDFLDIAYDEVPSKHYKESEDLTKFKSKKTERGPLKKDWKDNSSPLMCSYKVVKVKFEVFGLQTRVEAFTHKSVRDILLLGHRQAFAWIDEWIDLTMDDIREYESSTFEATNKKVLQADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AGI1</accession>
    <name>A0A3S1AGI1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_000894</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000013">
        <property type="protein sequence ID" value="RUS91377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AGI1"/>
    <dbReference type="STRING" id="188477.A0A3S1AGI1"/>
    <dbReference type="OrthoDB" id="6287073at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051277">
        <property type="entry name" value="SEZ6_CSMD_C4BPB_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45656">
        <property type="entry name" value="PROTEIN CBR-CLEC-78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45656:SF4">
        <property type="entry name" value="PROTEIN CBR-CLEC-78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="102"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="206"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="208"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS91377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="28644" checksum="A48E935F6A129D46" modified="2019-04-10" version="1" fragment="single">MLAFSTVIRYHCNPGYDLIGAQQVVCNYTWSHPPPVCQKLTCSLPAIPRGIFSYTGDLPEYGDNVTLTCDNGFILERTETSVTNLTCGEDRMLNIMDDTCIDEDECKNSSACSVTQVCMNTEGSFTCDCLPGYDGRMCTDVDECKQTTRGGCDQECINLDGGYECACKAGFLLYRENGTGLQFLRSGETGLRPGDVLRLNHSCVRSLCKAPPVAPMHGTILSAKSVFQSNDTVPIECDFGYKLIGSAVAVCEADGNWTSNASCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1ARK3</accession>
    <name>A0A3S1ARK3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PHTF1/2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_022137</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001491">
        <property type="protein sequence ID" value="RUS70098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S1ARK3"/>
    <dbReference type="OrthoDB" id="10066656at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039775">
        <property type="entry name" value="PHTF1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021980">
        <property type="entry name" value="PHTF1/2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12680:SF6">
        <property type="entry name" value="PROTEIN PHTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12680">
        <property type="entry name" value="PUTATIVE HOMEODOMAIN TRANSCRIPTION FACTOR PHTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12129">
        <property type="entry name" value="PHTF1-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1105"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1163"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1245"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1283"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="domain" description="PHTF1/2 N-terminal" evidence="8">
        <location>
            <begin position="3"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="166"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="335"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="790"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="883"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="960"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="335"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="369"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="816"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="891"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1000"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1019"/>
            <end position="1029"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS70098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1400" mass="155959" checksum="7DAA525715673006" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AVE9</accession>
    <name>A0A3S1AVE9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">fumarate hydratase</fullName>
            <ecNumber evidence="4">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_022880</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I fumarase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="4"/>
    <dbReference type="EMBL" id="RQTK01001714">
        <property type="protein sequence ID" value="RUS69355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AVE9"/>
    <dbReference type="STRING" id="188477.A0A3S1AVE9"/>
    <dbReference type="OrthoDB" id="411469at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.130.10">
        <property type="entry name" value="Fe-S hydro-lyase, tartrate dehydratase beta-type, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004646">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdA-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004647">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdB-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036660">
        <property type="entry name" value="Fe-S_hydroAse_TtdB_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011167">
        <property type="entry name" value="Fe_dep_fumarate_hydratase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00722">
        <property type="entry name" value="ttdA_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00723">
        <property type="entry name" value="ttdB_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43351">
        <property type="entry name" value="L(+)-TARTRATE DEHYDRATASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43351:SF2">
        <property type="entry name" value="L(+)-TARTRATE DEHYDRATASE SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05681">
        <property type="entry name" value="Fumerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05683">
        <property type="entry name" value="Fumerase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001394">
        <property type="entry name" value="Fe_dep_fumar_hy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117457">
        <property type="entry name" value="FumA C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic" evidence="10">
        <location>
            <begin position="2"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-S hydro-lyase tartrate dehydratase beta-type catalytic" evidence="11">
        <location>
            <begin position="258"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS69355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="472" mass="51258" checksum="BA77FFFF669AC45B" modified="2019-04-10" version="1">MYEAYKREESKPAKDAMAQILINSRMSAFGKRPICQDTGMVCAFVKVGMDAKLDRTDRTITELVNEGVRKAYSDVHNPLRASMVAPPHGARKNTKDNTPAIVHIDMVHGDKIDIEVAAKGGGSEFKSKFKVLNPSDSVIDWVEEMLPTMGAGWCPPGIIGIGIGGTAEKAMILAKECLGEEINMQDIIKNGPKDEVEQLRLDIFNRVNALGIGAQGLGGLTTVLDVKVNMYPTHAACKPVALIPNCAATRHIHFTLDGSGVVDLPTPKLEDWPVITQDQNADVKRVNLDTITKQEIESLRSGENILLSGRILTGRDAAHKRLKDMYDAGEEFPVDLKNKFIYYVGPVDPVGDEVVGPAGPTTATRMDKFTPFMLENVGIAGMIGKSERGQATIDSIKKNKAIYLMGVGGAAYLISKSIKEAKVVAFEDLGMEAIYEFEVVDMPVTVAVDSLGVSAHQQGPKLWKAKIAEIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AX61</accession>
    <name>A0A3S1AX61_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_021641</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallophosphoesterase superfamily. MPPE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001373">
        <property type="protein sequence ID" value="RUS70595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AX61"/>
    <dbReference type="STRING" id="188477.A0A3S1AX61"/>
    <dbReference type="OrthoDB" id="9984693at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF0">
        <property type="entry name" value="METALLOPHOSPHOESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="11">
        <location>
            <begin position="63"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS70595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="385" mass="44786" checksum="1AAE5ABA9A9C640A" modified="2019-04-10" version="1">MQCGKDRTVMAQAIIRSILILSFFALYCEYLHYFVVLLFCTWPPISSDSHDHHVPTALKDDLKAMFLADTHLLGSRDGHWFDKLRREWQMKRSFQTAMAIHRPDIVFVLGDLFDEGKWCDDDEFQYHASRFRSMFAVPEGTDLYVVAGNHDEGFHYMMTDHKHKRFEQEFHSPSVQLVMKKDAVFVLLNSMAMEGDHCHICAEAERDLHNVSKFLTTLQNCHHEEKPTGICQKYSKFYSKPILLQHFPMYRPSDADCNTVDSAPVSEKYIPFKEKYDCLDKRSTDLLLNLLKPRLVVVGHTHHGCFRILPGEVPEWTVSSFSWRNRNNPTFLLIRFSEGEHSISKCFLPEESTVINIYIFGCVCAVLNILVSSLKIKSLYRKKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AXK5</accession>
    <name>A0A3S1AXK5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UspA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_022375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001553">
        <property type="protein sequence ID" value="RUS69860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AXK5"/>
    <dbReference type="OrthoDB" id="843225at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31964">
        <property type="entry name" value="ADENINE NUCLEOTIDE ALPHA HYDROLASES-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31964:SF113">
        <property type="entry name" value="USPA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="147"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS69860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="237" mass="26498" checksum="D54138CDECC9B4F1" modified="2019-04-10" version="1">MSTKATPRNSISKSDSVDDSSEEEEESITPPKTELRSLMILKEGPIVVMPLDASKHSLYCLTFYIKYLHKPENMVHVCYVAEDYKRKSQITDSPDKKSNYTGCFGCIKRLLDRGSFVDNMGPSPGIIKELKQEDRLNCRLVRAKAKTLFLSNDVKNWAFTRLTGEDPWTAILDHRESVRGTLLVLGSRGLGVIKRTIFGSVSDKVLRKSTVPVLIVRMPEGALCSTIDVVTGSSFIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AXX0</accession>
    <name>A0A3S1AXX0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_022130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001490">
        <property type="protein sequence ID" value="RUS70105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AXX0"/>
    <dbReference type="OrthoDB" id="10059790at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS70105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="209" mass="24723" checksum="B884579F1E003FE5" modified="2019-04-10" version="1">MKELVCLHNPHQFTITIILNPDHRQYHHSHLALSLSDSECLELHINFNCIEHLSNLWALTQAEEKKLDAFHRKQLQRVVGIRYPVKITNKALYKQCNECPLSLYVLENRWRLFGHILRRDRETPANKAMEGFFVPQGDKYRGRPITTLPVVLNNDLSRLESSNYCLKTFKDIENLKKIAEQRDQWRILCTRIQKEAEALQSDDYDAERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AZK2</accession>
    <name>A0A3S1AZK2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_016064</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000682">
        <property type="protein sequence ID" value="RUS76186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AZK2"/>
    <dbReference type="OrthoDB" id="6130531at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043:SF8">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018592111" description="EGF-like domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="52"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="88"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="173"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="217"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="266"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="307"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="355"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="575"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="717"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="781"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="817"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="585"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="728"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="817"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="846"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="882"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="902"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="919"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="960"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="996"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1220"/>
            <end position="1230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS76186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1249" mass="135454" checksum="5C3777B52F9AC1BB" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B559</accession>
    <name>A0A3S1B559_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_015922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000672">
        <property type="protein sequence ID" value="RUS76315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B559"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS76315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="220" mass="25394" checksum="61AF1685A7A6AE7B" modified="2019-04-10" version="1">MQPNQSSLLVQRLPGHKSSMPTAEYRKDTQSRAEQSRIQSRIQSRIPRAGYRARYKAEYPEGTEQDTKQDTEQNTQRVQSRIQSTIPRGYRAGYKAQYPEGTEQDTKQNTQSRARYRAEYPEGTEQDTEQNTQSKSRAGYKAGYPEGTEQDTQSRAGYKAGYPEGTEQDTEQNTQSRAEQDTEQNTQRVQSRIQSRIQSRIPRAEQDVQRIQSRMPITTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B654</accession>
    <name>A0A3S1B654_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_016345</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Tdpoz family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000703">
        <property type="protein sequence ID" value="RUS75886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B654"/>
    <dbReference type="STRING" id="188477.A0A3S1B654"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18345">
        <property type="entry name" value="BTB_POZ_roadkill-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03774">
        <property type="entry name" value="MATH_SPOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000028">
        <property type="entry name" value="Speckle-type POZ protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000008">
        <property type="entry name" value="Speckle-type POZ protein-like a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056423">
        <property type="entry name" value="BACK_BPM_SPOP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24570">
        <property type="entry name" value="BACK_BPM_SPOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MATH" evidence="7">
        <location>
            <begin position="31"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="6">
        <location>
            <begin position="200"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS75886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="42340" checksum="7A6873FF7EE4C1F8" modified="2019-04-10" version="1">MAVCRVPTPPPPDVSCPVADNWCYTQVKVIKFSYIWTINNFSFCREEMGEVLKSSTFSAGANDKLKWCLRVNPKGLDEESKDYLSLYLLLVNCNKSEVRAKFKFSILNAKREETKAMESQRAYRFVQGKDWGFKKFIRRDFLMDEANGLLPDDKLTIFCEVSVVGDTENKPGQSNCTPVKVPECRLSEDLGQLFDRSSFSDVTLCVGGREFLAHKAILAARSPVFNAMFEHQMTESKQNRVDIQDVDHEVMREMLRFTYTGKAPNLDKMSDDLLAAADKYALDRLKVMCEEALCSSLTIESVCDILVLADLHSAEQLKTHAIDFINSHATDVMETSGWRTMIQAHPHLIAEAFRALASQQSPPLGPPRKRIKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BHT8</accession>
    <name>A0A3S1BHT8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_008025</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000213">
        <property type="protein sequence ID" value="RUS84221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BHT8"/>
    <dbReference type="STRING" id="188477.A0A3S1BHT8"/>
    <dbReference type="OrthoDB" id="6154409at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS84221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="31939" checksum="19B727212F77C9BD" modified="2019-04-10" version="1">MANNKLAEAEMVIRRAARISGVNLHKVMDVFRDRTQSMLVPVTPSREDGDLQQLHQDTAPPEPTKENFFMALKNKQIFKITAISFYMWFADSATYYGLILTSGSLVNDLYLGYAVNILVELPAGVAFFFMCDRYTRRTCMIFFHLVAGIALLAVVALNTIQAAQSIPGINIIVIIISLIGKFGSSAGYGVLWMYTPELFPTNIRTTGFGVSSLAARIGVIVTPFSRTLGRHLPWAPGVIFGILCLLIPVLTVFLPEMHGRELPQTLADMKTLKKVKSGRTHNNERSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BJN4</accession>
    <name>A0A3S1BJN4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_006933</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000175">
        <property type="protein sequence ID" value="RUS85286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BJN4"/>
    <dbReference type="OrthoDB" id="6091802at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS85286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="40332" checksum="C6BE2ED29C25D195" modified="2019-04-10" version="1">MWSILRTMAPIGFQERDQAVYHNQSGTETNGTVSDFTDKGMYFGLGKESLYLQIILTLVIGVFGITGNIMTLMVYSKLGFYNTINISYSVLAASDLCCVIASIVNIMGYIDPFFQDPRLQTLTNFAKLFGAYPFFAFSRITGLITAWISVERSLCVVFPIRVKLIITPRVNTAVLCTLIIVGFFPICFMYTSHEIQWQFDPRTNSTILVLVQLNKLQNVALLLFGAVYPMIIWITVVCCTASLVFKLKQSNRWRKHNASGMTSLSPTGTSGTARRIQQRAAVGQGEADHKACNFSSTGSQRQFYLTLGVATKAMTQINSSVNVIIFAVSGQRFRSVLRQILKACFCKSNIPVSPVTANQRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BQR6</accession>
    <name>A0A3S1BQR6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_003062</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="RQTK01000063">
        <property type="protein sequence ID" value="RUS89183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BQR6"/>
    <dbReference type="STRING" id="188477.A0A3S1BQR6"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="112"/>
            <end position="230"/>
        </location>
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</entry>
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                <person name="Li Q."/>
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                <person name="Li J."/>
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                <person name="Wang J."/>
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</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="312" mass="35084" checksum="538A92EEA38BEF2D" modified="2019-04-10" version="1">MSDQATSWGRDYVISYHSVERKACTDQCGADINKLIALLEFRPADFPIGGPALYHLHSLPFFRHLKRSRKIRGKKSGGRTRNLPVGSCALYIRPMYGKSGEGTLTAFNIRRKRMELQSELFDSEMLCLATMKQGQKLICGTGEGTLNFFNWGEWGNISDRFPCGEAQINCIMPVTEYVAAIGTDDGFIRNLPVCPPAPVKRRAKRNPCYRPNLQEEPDMACARCLHYDDQNLSHRPVTEALAPKKKSPQRKLAGNLPAPDAPRKPRGESAFRVRELARDNMAPRRLDFDSSDSEEDDDDSGYGGRPWFLVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
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                <person name="Yang H."/>
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                <person name="Li S."/>
                <person name="Pierce S.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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    <dbReference type="EMBL" id="RQTK01000003">
        <property type="protein sequence ID" value="RUS92026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BVA2"/>
    <dbReference type="OrthoDB" id="6162331at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="302"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS92026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="333" mass="36648" checksum="57E32A06ACF50038" modified="2019-04-10" version="1">MDSFFLFPIDEDDFVSDTSSFNETDKAHSKCGISHEEGSCDDEVFATRPGETFTTTATSTRVSHRRSGISNVRSQTTAHRKMKPPSSPTLPPPVGSSSGAFPNRGRRWSLDVISPLRLLVTPHGSASTGRRPSAPDDQTGSGDDSSPGPTPPAVAAPSIHHGGRRYSQPIIPKVKPIKDKRVKVKDLAGKKGGKSGQHKAKESYVLATLDTGQTVVLTCKDDDRHLKQLLSVAMMDRRVLSYRMIVASSRGVLKGGHSAMGGLNGRKVRSCENLLEVLSEPDDEWEREEALRVMPEIMSSCRRREILKEMARTDRQYYDNLQAVFDSYAEPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BVX9</accession>
    <name>A0A3S1BVX9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_016044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000681">
        <property type="protein sequence ID" value="RUS76200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BVX9"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018688364" evidence="2">
        <location>
            <begin position="21"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS76200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="212" mass="22889" checksum="76A1784E11F9028C" modified="2019-04-10" version="1" fragment="single">MRRQLRLLLLLLSLTLLVHGHQRPAGSLEDDQQGDQGENSLEGDSTFTLHRDGGRETNILTKMADSLREIASRASSMVFLSGTVAREEAQTGGTDVTKTGMQGRLSGFLGDGNDVTSGDATSKGKMALMDGRNDVKVDDSGSESDMRDHISEIWKQTKEKSPKMTSKVHGHGPNPPTANGQASAVMSDQQLIGEPWSGQTLEQQGEGFSKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C259</accession>
    <name>A0A3S1C259_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FACT complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EGW08_011373</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">EC2010</strain>
            <tissue evidence="15">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the FACT complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peptidase M24 family. SPT16 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000369">
        <property type="protein sequence ID" value="RUS80854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C259"/>
    <dbReference type="STRING" id="188477.A0A3S1C259"/>
    <dbReference type="OrthoDB" id="10251642at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032786">
        <property type="term" value="P:positive regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01091">
        <property type="entry name" value="CDC68-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.150:FF:000003">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.210:FF:000001">
        <property type="entry name" value="FACT complex subunit spt16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000017">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000005">
        <property type="entry name" value="FACT complex subunit spt16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000005">
        <property type="entry name" value="SPT16 homolog, facilitates chromatin-remodeling subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.210">
        <property type="entry name" value="FACT complex subunit Spt16p/Cdc68p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029148">
        <property type="entry name" value="FACT-SPT16_Nlobe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056595">
        <property type="entry name" value="Fact-SPT16_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048969">
        <property type="entry name" value="FACT_SPT16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013953">
        <property type="entry name" value="FACT_SPT16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040258">
        <property type="entry name" value="Spt16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033825">
        <property type="entry name" value="Spt16_M24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980">
        <property type="entry name" value="CDC68 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980:SF15">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14826">
        <property type="entry name" value="FACT-Spt16_Nlob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24824">
        <property type="entry name" value="PH_SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08644">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21091">
        <property type="entry name" value="SPT16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01285">
        <property type="entry name" value="FACT-Spt16_Nlob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01286">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FACT complex subunit SPT16 N-terminal lobe" evidence="12">
        <location>
            <begin position="5"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="FACT complex subunit SPT16 middle" evidence="13">
        <location>
            <begin position="529"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="14">
        <location>
            <begin position="806"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="449"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="918"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="462"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="927"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="984"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1013"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1042"/>
            <end position="1052"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RUS80854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1059" mass="120298" checksum="AAD58CE827ED21B9" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1CCW5</accession>
    <name>A0A3S1CCW5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Store-operated calcium entry-associated regulatory factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Transmembrane protein 66</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EGW08_003008</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">EC2010</strain>
            <tissue evidence="16">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SARAF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000061">
        <property type="protein sequence ID" value="RUS89265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1CCW5"/>
    <dbReference type="STRING" id="188477.A0A3S1CCW5"/>
    <dbReference type="OrthoDB" id="20303at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006816">
        <property type="term" value="P:calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001256">
        <property type="term" value="P:regulation of store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009567">
        <property type="entry name" value="SARAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929:SF0">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06682">
        <property type="entry name" value="SARAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="205"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="287"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="295"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RUS89265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="331" mass="35548" checksum="F5C53E7885352ED0" modified="2019-04-10" version="1">MQAMKMMHTMDSRGGFKSTLLSLILTAVLTFATAAFNDYHHSDKMLLSDVKALTLRQGQMTNARRSPPVPQLKCVGGAAQYKFTPKVVQCINMGSDGHDIQWECKTDMDNAYRFGNVEVTCEGYDYPNDPYVLKGSCGLEYTLEFTEEGVQRERQKGGSGYQYSYNSKHSSEGGMSGLFVFAAVLLAIYVIYKTCIAPTAQGAYQTGADQQPPPYGFRPEFTQPQGPPPPYDGWGTPDPSCGQSHYSAGYGRQHHSAGGTGGGFWSGAATGGLLGYMFGSRNNAGHSYRGRSWQSAAPSGGFFSSDSGSPSSSRGSSGTRTASGFGGTSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1CDE3</accession>
    <name>A0A3S1CDE3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_002582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000050">
        <property type="protein sequence ID" value="RUS89661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1CDE3"/>
    <dbReference type="OrthoDB" id="6043982at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS89661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="29096" checksum="6CB5D6AD0B8B643B" modified="2019-04-10" version="1">MMHGGVYPSISFSSSGCSAELLEGNRSQPIPEGVASEWLNENSMVGASPYKAPQDHMTSNGYTLDKATYDTEGDLTVVESTNQQCIIYVSHTVRESDRVNPFIAALRKHFLTCTFETSALCVEMRDKKDSIARCEFVLLFMSDTYSESHEMAMEYSLFEGKKVLVAAHSEMHWPPGNYFKDKRKEMERCHMVKVNKSDNKADVEALINLVDAQLQESNKNKPMNGTTTNSKSGKGKSGGKSSPSSKSSQSPSKENSSSTCRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H1W4</accession>
    <name>A0A3S1H1W4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_021682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001382">
        <property type="protein sequence ID" value="RUS70553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H1W4"/>
    <dbReference type="OrthoDB" id="6162582at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018571027" description="C-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS70553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="14393" checksum="0814E4EBFE695212" modified="2019-04-10" version="1">MLALQRFAFPIILSFISSAFEQGQIRPPRNSNPQSGANFVCPSGSEYNARFKMCLQKYLDLKPWRTARKKCRSHGGDLLTILNEEMNQALYGIYVSYLELMMYNNISYYSLMIKSYQQIEILTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H9Q0</accession>
    <name>A0A3S1H9Q0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_017258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000780">
        <property type="protein sequence ID" value="RUS74991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H9Q0"/>
    <dbReference type="STRING" id="188477.A0A3S1H9Q0"/>
    <dbReference type="OrthoDB" id="10070415at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF25">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="97"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS74991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="579" mass="66726" checksum="EBA6DA162367A49D" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HL71</accession>
    <name>A0A3S1HL71_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_010451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000321">
        <property type="protein sequence ID" value="RUS81759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HL71"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS81759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="129" mass="13689" checksum="B1738C42AB36CCE5" modified="2019-04-10" version="1" fragment="single">AVWMLRLDVQEMGSRVLCCVAAVLTHVQLGASLFWSEGYGLDVHLAGMGLQGASLCESLAAVLAFVGPDTYPHTCVSSCVPLEIEGVVEALATDPAQVPLVGAVVFQVSVQKTLEIKRPVAYMALWFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HP59</accession>
    <name>A0A3S1HP59_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_008857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000245">
        <property type="protein sequence ID" value="RUS83391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HP59"/>
    <dbReference type="STRING" id="188477.A0A3S1HP59"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS83391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="154" mass="15790" checksum="D9177ADDB6A57CEA" modified="2019-04-10" version="1" fragment="single">SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSRSSSSSSRSSSSSPKLVGYRARVSMGYRARVSMGYKARVSVGYRARVSVGYRARVSMGYRARVSMGYRARVSVGYRAKVSEGYRAKVSMGYRARVSMGMTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HQD1</accession>
    <name>A0A3S1HQD1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_008194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000219">
        <property type="protein sequence ID" value="RUS84082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HQD1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS84082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="145" mass="14749" checksum="8724C1A9E86CA292" modified="2019-04-10" version="1" fragment="single">ATCSLRGGQLATCSLRGGQLATRSLRGGQLATRSLRGGLFATCSLRGGQLTTRSLRGGQLATCSLRGGQLATRSLRGGLFATCSLRGGQLTTRSLRGGLFATCSLRGGQLATRSLRGGQLATCSLRGGQLATCSLRGGQLATCSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HX58</accession>
    <name>A0A3S1HX58_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_004345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000097">
        <property type="protein sequence ID" value="RUS87929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HX58"/>
    <dbReference type="OrthoDB" id="10382504at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018707047" description="Chitin-binding type-2 domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="33"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="103"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS87929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="182" mass="19948" checksum="3BAF547246996A01" modified="2019-04-10" version="1">MQLQTKLALAALTVFLGSCNAYQFLWGLNQEMNALCPNQKGASEVGVLDPCDINNFIMCFDGQAIAINTCAANGRFNREKNACDFIDQVAAPTNCKQITQPSNKTCGEPGVMVAAMKDSCKFYYSCTTAGAQKMQCNHLSFFIEEEGRCMFITEGFRSSIPRAALDDCEAKDPYTDAEIAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1I1S1</accession>
    <name>A0A3S1I1S1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alcohol dehydrogenase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_001708</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000030">
        <property type="protein sequence ID" value="RUS90531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1I1S1"/>
    <dbReference type="STRING" id="188477.A0A3S1I1S1"/>
    <dbReference type="OrthoDB" id="417550at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051903">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000003">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF12">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE CLASS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="5">
        <location>
            <begin position="117"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS90531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="292" mass="31612" checksum="584A011936CDE9E3" modified="2019-04-10" version="1" fragment="single">GDHVIPLYTPQCYDCKFCKNPKTNLCQRIRATQGQGVMPDGTKRFTCKGKELFHFMGCSTFSEYTVCAEISVSKVDPKAPLDKVCLLGCGISTGYGAALNTAKVSEGSICAVWGLGAVGLAVIMGCKAAGASQIYGIDINPAKFEAAKQFGATHFINPKDYPDKTIQEVVMSMTDGGFDYTFECIGSVHTMRAALECCHKGWGESTIIGVAAAGQEISTRPFQLVTGRVWRGSAFGGWKSRDAVPKLVDEYMSKKLKVDEFVTFTLPLGQINDAFEYMHTGKSIRSVIVFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1I246</accession>
    <name>A0A3S1I246_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Homogentisate oxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Homogentisic acid oxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Homogentisicase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">EGW08_001477</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">EC2010</strain>
            <tissue evidence="19">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="4"/>
    <dbReference type="EMBL" id="RQTK01000025">
        <property type="protein sequence ID" value="RUS90766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1I246"/>
    <dbReference type="STRING" id="188477.A0A3S1I246"/>
    <dbReference type="OrthoDB" id="1689029at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07000">
        <property type="entry name" value="cupin_HGO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000026">
        <property type="entry name" value="Homogentisate 1,2-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046451">
        <property type="entry name" value="HgmA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046452">
        <property type="entry name" value="HgmA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01015">
        <property type="entry name" value="hmgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056:SF0">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04209">
        <property type="entry name" value="HgmA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20510">
        <property type="entry name" value="HgmA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="10 16" id="KW-0408">Iron</keyword>
    <keyword evidence="6 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase N-terminal" evidence="18">
        <location>
            <begin position="6"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase C-terminal" evidence="17">
        <location>
            <begin position="277"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF20510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RUS90766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="445" mass="50277" checksum="91A95C03AFA5AFBC" modified="2019-04-10" version="1">MSSELKYLSGFDNEFATEDPRCPGALPEGQNNPQKCAYGLYAEQLSGTAFTAARHENRRTWLYRIRPSVVHTPFQKIDKGLLTHDWDTVEPNPNQLRWQPFDFPEKNQDFAQGLATICGAGDPKSRNGIAIHMFLCNKPMEDKCIYNSDGDFLIVPQEGTLFITTEMGKMNVEPNEICVIQRGMRFNVDVKGNTRGYILEVFSDHFQLPSLGPIGANGLANPRDFLTPVAWFEDREVSQYTVINKYHGHLFAATQGHSPFDVPAWHGNYVPYKYNLSNFMVINSVSFDHADPSIFTVLTCPSLKPGVAIADFVIFPPRWSVQENTFRPPYYHRNCMSEFMGLIYGKYEAKEDGFRPGGASLHSMMTPHGPDLGCFEKASNAPLKAERIAEGTMSFMFESSLSMAVTPWGNNTKVDKNYYKCWQPLKKYFNSNNKDSNVADALTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SJ10</accession>
    <name>A0A433SJ10_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_023404</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001979">
        <property type="protein sequence ID" value="RUS68833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SJ10"/>
    <dbReference type="STRING" id="188477.A0A433SJ10"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS68833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="194" mass="22870" checksum="689595113BF7D136" modified="2019-05-08" version="1" fragment="single">SAVFQISPCLPNLALYPYLELFTESRVVFQISRCFPNFELSRWISCCLQNLELFTEYRAVYPISRCFPSFELSAGFRAVYKISNCLPNIALFTKSRTVYRMSRCLPNLELFTEYRAVYRISRCLPNIALFTEYRAVYRISHCLPNIALFTEYRTVYRISRCLPNIALFTEYRAVYRISHCLPNIALFTKSRTVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SJT9</accession>
    <name>A0A433SJT9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_022857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001703">
        <property type="protein sequence ID" value="RUS69379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SJT9"/>
    <dbReference type="STRING" id="188477.A0A433SJT9"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="1">
        <location>
            <begin position="30"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS69379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="239" mass="27738" checksum="7BAE55626B489464" modified="2019-05-08" version="1">MVLFDNVFSGQRVEVKWNNGIYKGIVRYKGPVATKRGDWVGIALDHPGYHILFTGLTPSTVGDCAGMLFGRRYFQCRPSYGVFVRADKVRFIRTVRCLYDRYRKISSESLVDEHLFDTPSDPCFVFVYFHTLKDYSAPWDVAPKYSLRHSVGNRIPAATMLRAATTGSPFRYRSRPIHVDYLMDDEFENRPSVPFTHMPHSALREQVRRGWHGSHYVRQMTVPTGRELMKYSQWNDISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SLE4</accession>
    <name>A0A433SLE4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EGW08_022272</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">EC2010</strain>
            <tissue evidence="17">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the integrin alpha chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001525">
        <property type="protein sequence ID" value="RUS69964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SLE4"/>
    <dbReference type="STRING" id="188477.A0A433SLE4"/>
    <dbReference type="OrthoDB" id="5573735at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.930">
        <property type="entry name" value="Bicelle-embedded integrin alpha(iib) transmembrane segment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1460">
        <property type="entry name" value="Integrin domains. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1530">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018184">
        <property type="entry name" value="Integrin_alpha_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013649">
        <property type="entry name" value="Integrin_alpha_Ig-like_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048285">
        <property type="entry name" value="Integrin_alpha_Ig-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF122">
        <property type="entry name" value="INTEGRIN ALPHA-PS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08441">
        <property type="entry name" value="Integrin_A_Ig_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20805">
        <property type="entry name" value="Integrin_A_Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00242">
        <property type="entry name" value="INTEGRIN_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0401">Integrin</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1069"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="311"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="378"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha first immunoglubulin-like" evidence="15">
        <location>
            <begin position="486"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha second immunoglobulin-like" evidence="16">
        <location>
            <begin position="639"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1108"/>
            <end position="1130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RUS69964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1130" mass="124361" checksum="166F2DCBDF1FB91F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SQL8</accession>
    <name>A0A433SQL8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Heat shock protein 70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_020686</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001198">
        <property type="protein sequence ID" value="RUS71546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SQL8"/>
    <dbReference type="STRING" id="188477.A0A433SQL8"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000024">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="594"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS71546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="634" mass="69543" checksum="BDFC3FEBD36D129D" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SQP3</accession>
    <name>A0A433SQP3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_020657</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001192">
        <property type="protein sequence ID" value="RUS71579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SQP3"/>
    <dbReference type="OrthoDB" id="6141171at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019067671" description="WAP domain-containing protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS71579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="15691" checksum="87B8F2B068F0ADD6" modified="2019-05-08" version="1">MRVSYQTTAALLVCVFLLSWVEVTTSAPANKCLLKCMLSVLKCKRDAGVGLTTGDDCCDKYTLCYFACEPDATEAPSCRTKKYNTSYDGKRGSWSKRGSWNKREPPMTGEWADRGQQLSEDQVLPPRLKSASGNMEKVPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SR65</accession>
    <name>A0A433SR65_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">URB1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_020493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001166">
        <property type="protein sequence ID" value="RUS71750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SR65"/>
    <dbReference type="STRING" id="188477.A0A433SR65"/>
    <dbReference type="OrthoDB" id="72892at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039844">
        <property type="entry name" value="URB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032436">
        <property type="entry name" value="URB1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500:SF0">
        <property type="entry name" value="NUCLEOLAR PRE-RIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500">
        <property type="entry name" value="NUCLEOLAR PRERIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16201">
        <property type="entry name" value="NopRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="URB1 C-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS71750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="473" mass="51791" checksum="70CA8795B55FDA26" modified="2019-05-08" version="1" fragment="single">YKQERNWALSLLAEGLRDTSDYWLYQKKSVFKIILSFYGSALSDKTSQALVLSVVKAACMEKTVAVHLVKDQGLLTWLSSAVDGLASRPEHCDALCEIVHALWTSLSTHRYHKEEGRSVEEITEGDGDEQEKEKEAAGNDSSDMDEVSSDDDDDNDDEDTVEETDESDDSDNQTVSSDRTGKSKKRKIPSNQGVNKKQKLSDSYDEGIQDKSLKKTKKDSESDSEAMSSDEDNTEILNGVQSGTKSLKLERSKQVKRGTRPSMPKSTVAELGLLVRGLVWHLSTTSIKNVGKLLEVHRGLIDLMHQSSVSQHGPSATNTSTEQDKLIHDQQSSLSGAEACLILHRLGSTAQIPQLVSAVETELVRLGVDVKSTVCRSIQGNNGIKSIGKLNSEEAKGAEEPLEVEDLKQSSQTGQGEEDDEGKVGPGLQSADEGGETLQFPNDSTDLESKELARTLLISTREIFTLTQSVEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433ST06</accession>
    <name>A0A433ST06_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_019842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001072">
        <property type="protein sequence ID" value="RUS72405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433ST06"/>
    <dbReference type="OrthoDB" id="6161002at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS72405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="229" mass="23484" checksum="371AD9BF275B4C27" modified="2019-05-08" version="1" fragment="single">RIVRNKANDRSKSSSPHGPDGSPPCTAGDASNPSSEGGPRTVSGGPVTASGGFNISSIMSPSGNNSSSNNNNNNNSNNNNNNSSTNGSHKRKVDADTGSNGIRDASQDMAENRIRWYDRTPPKAPRADMGGSNPLELTPGQEDPSPASYLGLAGSYHQASMAFSSGGDIKQEFHVSPPRAGGEQGGGGGPVYPMAPPISYGGNPSAYEQGSVNTSVPLAVLPQVYNAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T0W5</accession>
    <name>A0A433T0W5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_017044</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000764">
        <property type="protein sequence ID" value="RUS75185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T0W5"/>
    <dbReference type="STRING" id="188477.A0A433T0W5"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS75185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="452" mass="51325" checksum="C2E2C68E2BF28D3A" modified="2019-05-08" version="1">MDGIMDDIMDGIMDGLMDSIIMDDIIDDIMGDIMDGIVGGIMDDIMDGIMDDIMDGIMDSMVYYIMDDLLDAITYDIHVMDDVMYDAMDDIVDGMVYDMIDNTMDDILDDIMNGMVDDIMDGIMDDKMDGRIDDIMGDIIDVIVDDIIDAIMDAIKEIIVNGIMDDIIDGIMDDIIDGIRNDKMDGIMDDDMVYNIMDAIMDDIKEYFMDGIMDDIMHDTMDAIMDDIIDVIVDAIIDAIMDDIKEYIMDGIMDGIMDGIMDDIINGIMDDIMDGIMDDIMDDIMDGIMDDIMDDMVYDIMDDVMDAIMYDIMDDVMYDVMDDIMDGMVDVIKDGIMDDILDDLLDGTMDDILDDIMGGMVDDIMNDIMDDTVDGIIDGVMGDIIDDIMDDIMDDTVDDVMNVDPRTTRLSLRVTRQRTREHYIRWCRVYISMYNRLGTIKWRSTALSCDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T0X7</accession>
    <name>A0A433T0X7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_017048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000764">
        <property type="protein sequence ID" value="RUS75189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T0X7"/>
    <dbReference type="OrthoDB" id="10468468at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS75189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="343" mass="39082" checksum="826DCD5A1C9001FB" modified="2019-05-08" version="1">MIMANLFSASNQSAPLEVNHECEYFPNGLESVRLESGDRWKQCKKYDDHDKHYFPANDIIDRSSSLNEDQRRLLREFSNRVVGILVEWTSELRPSDYPWADKRGTRELRFGTGFVYYVSKRKEGQPCPCEDCRGKVTTHWTFFVRTAFHVVFNSDEAKETRIDLFYDEKGFGDDSRTVWAVSMEESESSKDTDQSILLCVTHEEQVAQKLTSSGSFWPTLVDRSLIYYPENRGLVHALGLEDAIKGFDHAVIFSHPHGEPKKISVGRLVEHNDHSTFNLPPGIKYRTPTCPGCSGAPVILIKAQSDFLDPKRFPWNGPVHRASRGSTSPINYSQSGSYQYPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T223</accession>
    <name>A0A433T223_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Microsomal glutathione S-transferase 1</fullName>
            <ecNumber evidence="5">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EGW08_016708</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">EC2010</strain>
            <tissue evidence="17">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:16438"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotrimer; The trimer binds only one molecule of glutathione.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MAPEG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="5"/>
    <dbReference type="EMBL" id="RQTK01000732">
        <property type="protein sequence ID" value="RUS75540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T223"/>
    <dbReference type="STRING" id="188477.A0A433T223"/>
    <dbReference type="OrthoDB" id="193139at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.550:FF:000002">
        <property type="entry name" value="Microsomal glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040162">
        <property type="entry name" value="MGST1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10689">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10689:SF6">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RUS75540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="150" mass="16736" checksum="D37837F770134A78" modified="2019-05-08" version="1">MDQVLVFTVANPTFKYFLAHSAVLITKTLSVALATGLNRAYLNEEDAKATVFGAHDGKPRSTPTIDRLIRMHRNDLENIIPFLLTALLYIATKPDPDIALWHFRLFTGSRLLHSVVYFFALPTNARASCWFTGVGVTLSMAYRVFCNGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T5A0</accession>
    <name>A0A433T5A0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CNNM transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_015484</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ACDP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000638">
        <property type="protein sequence ID" value="RUS76753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T5A0"/>
    <dbReference type="STRING" id="188477.A0A433T5A0"/>
    <dbReference type="OrthoDB" id="5353557at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008340">
        <property type="term" value="P:determination of adult lifespan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905941">
        <property type="term" value="P:positive regulation of gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040018">
        <property type="term" value="P:positive regulation of multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032026">
        <property type="term" value="P:response to magnesium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000006">
        <property type="entry name" value="DUF21 and CBS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF94">
        <property type="entry name" value="UNEXTENDED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25562">
        <property type="entry name" value="CNBH_CNNM2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019187711" description="CNNM transmembrane domain-containing protein" evidence="10">
        <location>
            <begin position="26"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="11">
        <location>
            <begin position="151"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="676"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="729"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="802"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="677"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="738"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="807"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="842"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="878"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS76753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="919" mass="101764" checksum="79CFFE5559532B77" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T7K6</accession>
    <name>A0A433T7K6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_014700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000573">
        <property type="protein sequence ID" value="RUS77546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T7K6"/>
    <dbReference type="STRING" id="188477.A0A433T7K6"/>
    <dbReference type="OrthoDB" id="443915at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000373">
        <property type="entry name" value="fibronectin type-III domain-containing protein 3A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050617">
        <property type="entry name" value="E3_ligase_FN3/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099:SF11">
        <property type="entry name" value="FIBRONECTIN TYPE III DOMAIN-CONTAINING 3BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1043"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="123"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="302"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="394"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="486"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="613"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="703"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="915"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1073"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1030"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS77546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1110" mass="120150" checksum="B68942B3406585C8" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T7Q4</accession>
    <name>A0A433T7Q4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_014741</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="RQTK01000576">
        <property type="protein sequence ID" value="RUS77494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T7Q4"/>
    <dbReference type="STRING" id="188477.A0A433T7Q4"/>
    <dbReference type="OrthoDB" id="302728at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF452">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="205"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS77494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="388" mass="44661" checksum="5782A69071503B55" modified="2019-05-08" version="1" fragment="single">YTKDPNLGLGEKWRRFKEDKGKKGGRSAYYLDRWVPWYFYSVLVGAYAWFALAAVPAHHFRDPIWYTINEMFGLYVEIQLLVNWLLIHRTDSSYQPGPEDSASLGLLEDSVSSRESDLLIGDQPHTVNRNNNTPFSSSPSSSKAWSSEADALCENRLSELYNGDTRCSPGGYKTGLTYQMMVATGITSSGEVQRKSFPYWSWVPCLWCRRLRPPRCHHCTLCKRCVLKRDHHCYFTRVCIGVNNQRHFLVFLFWSIVMTSLASCELVPYTLNRVFSTYSWWNALFPVNLISVLSGQLPVSYLHLILMVWSLVFLFFVSLGMFTVHLFCTLRGLTKFEYDNRIQVESTLPLFARLQAVMGRNWGLAVLLPGYINGPPLEDGIKWPRVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T8B1</accession>
    <name>A0A433T8B1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_014414</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000549">
        <property type="protein sequence ID" value="RUS77821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T8B1"/>
    <dbReference type="STRING" id="188477.A0A433T8B1"/>
    <dbReference type="OrthoDB" id="6086001at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00173">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039111">
        <property type="entry name" value="STAP1/STAP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16186:SF9">
        <property type="entry name" value="SH2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16186">
        <property type="entry name" value="SIGNAL-TRANSDUCING ADAPTOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="4">
        <location>
            <begin position="173"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="79"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS77821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="335" mass="37156" checksum="4316CD69346BE916" modified="2019-05-08" version="1" fragment="single">MDHKSKLECKGGDPKSGYKFELYTPKRLSYCKTQKSCERELWRAYVEGITKGRISDNIDLFPAQIREIQDQLGRYFTAKMAPGGPVSPGLGPGAMRRDSDPGSFNSFDSPQSSSSGSFETSIPQDYLEPVSVTDTLTSEGTHQGLDSHSPDNNNNSSELVFYSGPARSGRPSWYFDSCSRRQAEQILEDRNHLGNTLMRSRPGSQKDLVISKMNGTVGTASFSHFIVRCHSNGYKIDVENPHEPMGSLSEVMNFFVETSGRSSTRPMSRDDLNRLDETDSNPYNMSIISGTLEYPDFFPPPPPPLSASDMQTMAQFQHNPVSNLPALPPPHIPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T9E1</accession>
    <name>A0A433T9E1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_014015</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000525">
        <property type="protein sequence ID" value="RUS78201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T9E1"/>
    <dbReference type="STRING" id="188477.A0A433T9E1"/>
    <dbReference type="OrthoDB" id="588261at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03499">
        <property type="entry name" value="SQR_TypeC_SdhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.540">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018495">
        <property type="entry name" value="Succ_DH_cyt_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978:SF5">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01000">
        <property type="entry name" value="SDH_CYT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS78201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="135" mass="15346" checksum="CA01F9CDB149100E" modified="2019-05-08" version="1">MALLIRSVARSSCLLKQTSMMVPKRSNMATTAYEEMSTFWARNRKLNRPLSPFLTVYKPHLAMMTSLTHRVTGVAMQNSSQLDSLSLFIFFFFFQAWDAGYGFSLKTLYKSGYFVMALTAVVTTYFVFGVKCNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TAG7</accession>
    <name>A0A433TAG7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_013689</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000503">
        <property type="protein sequence ID" value="RUS78546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TAG7"/>
    <dbReference type="STRING" id="188477.A0A433TAG7"/>
    <dbReference type="OrthoDB" id="6141508at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000036">
        <property type="entry name" value="CYtochrome P450 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008069">
        <property type="entry name" value="Cyt_P450_E_grp-I_CYP2D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF403">
        <property type="entry name" value="CYTOCHROME P450 306A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01686">
        <property type="entry name" value="EP450ICYP2D"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS78546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="495" mass="56234" checksum="9B56D745A35730C9" modified="2019-05-08" version="1">MVFPNILALLDSWTLIIAIAVFVLVMLLQTWLREPPNLPPVPGRPHLLLGHLPYLGANRREQMAQWRKTCLGSVRSCVARAKSCVHVHLEEVWHGEELSSRENPRRGVLGASGAAWREQRAVSMSILRKFGMGKNSLAEKIQEEITAYLNVLSQLGGEPSDVKRVTSATLSNVICSIIVGKRFEYDDPYFLQFMDTFSEQVRLVSSTSIINVFPWLRHLPGDMFGAKRFIDCHHDLDEIFSDPFIAQKTKEYKEGGDAMDNFISAYLQEWRRKEQDGETTTMDDGHLRRLLGNLFIAGSETTATTMLWFMLYMLHYPHIQEKVFAELEEKVGHNRRPTMQDKNRLPYLNAVIMETLRRASIAPFSLSRMCTADVTLQGYLIPRGSRVVSNLDSVLLDEVTWGDPLTFRPERFLDDQGGLLHPEEFVPFSMGRRVCLGESLAKMELFLFLGALVQRFRLLPSVPGQLPPQKALFGVTCPPEPFTLRLVERSEGVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TBC5</accession>
    <name>A0A433TBC5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_013388</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000486">
        <property type="protein sequence ID" value="RUS78846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TBC5"/>
    <dbReference type="STRING" id="188477.A0A433TBC5"/>
    <dbReference type="OrthoDB" id="408954at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="125"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS78846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="293" mass="34255" checksum="4B3EC85A792E5F0C" modified="2019-05-08" version="1">MDLVLHYSDRFFFTPYVYPTDWQEDLPLRQVISLLLIANIGGYLLYFIVAGLSYVFIFDHKLMTHPQILQNQIRKEITVAVLSVPLMSIPTVAIFFAEVRGYSKLYDNVADTRLGMAGVFLSMFTFIAFTDMCIYWIHRFLHHRLVYRHLHKLHHKWKVPTPFASHAFHPADGFLQSLPYHMYPFIFPLHKLTYLGLFVFVNIWTVSIHDGDYRVPETLQPLINGSAHHTDHHLLYNYNYGQFFTLWDRIGGSFRSPNAFEGCGPLDTVKALEKERQAKQELEKSTNSHVKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TC91</accession>
    <name>A0A433TC91_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_013034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000464">
        <property type="protein sequence ID" value="RUS79205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TC91"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS79205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="137" mass="15316" checksum="B3B9A0F276B460B1" modified="2019-05-08" version="1">MISLQFYKMVTYRSTRKPVHLTAQEVLDTYFMDGSGDEDDEKNIDLDPDSDKEDDSDILNDVPQPLDVTNEAAISESSFSTSVSVDGDKDPAEVSRSRSSRAVSQIESLDSSDIEEESGEDEVDQVDLDLYRHGKMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TFS3</accession>
    <name>A0A433TFS3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_011806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000391">
        <property type="protein sequence ID" value="RUS80437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TFS3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS80437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="102" mass="11129" checksum="ED3C4F7D954A66FE" modified="2019-05-08" version="1" fragment="single">MPYEDRDHCESYGKKLKLCQDDPECVFCRQGVDGVEESKAGLCVHRSRTQTCAERDYHDATDRCPGICAASHTCGACVSHGGTHSDSGKNSSDLDINPHTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TGV8</accession>
    <name>A0A433TGV8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NR LBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_011463</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nuclear hormone receptor family. NR0 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000373">
        <property type="protein sequence ID" value="RUS80793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TGV8"/>
    <dbReference type="STRING" id="188477.A0A433TGV8"/>
    <dbReference type="OrthoDB" id="9926883at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033544">
        <property type="entry name" value="NR0B1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24081:SF8">
        <property type="entry name" value="NR LBD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24081">
        <property type="entry name" value="NUCLEAR RECEPTOR SUBFAMILY 0 GROUP B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NR LBD" evidence="10">
        <location>
            <begin position="373"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="97"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="258"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="331"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="97"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS80793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="598" mass="63906" checksum="CFF317FD8F4D0797" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TGY8</accession>
    <name>A0A433TGY8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_011435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000372">
        <property type="protein sequence ID" value="RUS80814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TGY8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS80814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="219" mass="23656" checksum="43D523BEA266DA1A" modified="2019-05-08" version="1" fragment="single">MGQKQGTHVPSGRSIEEDGGAGLSRKQQKMLAPGSYIQVPQGTNPYGHPVPHPMEFGNHGQYHRKQGKRSSQRAPPGFSGPHPMGIPYPMYPGSEAPPAFLYPGGPPPVMYGPPRPGSIYQPELVPVGYPRYPPSYSPDMVPNGTSSMRSAALDSRSPNPQVDQSTRWSKTIKEPNRISKHVDENANEIAIDANDVDIGGVVNTVPEKAVPESIKQVDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TMX0</accession>
    <name>A0A433TMX0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_009311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000265">
        <property type="protein sequence ID" value="RUS82927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TMX0"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS82927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="114" mass="13531" checksum="71E942CFF84D1043" modified="2019-05-08" version="1">MVLTYSFKYFREMALLYSLVDSAWLNHSVIFCCVTFNSIAFKHDNLCLTSSYRDKTWTCKLLTLMFFLQMIGLNIYVCYPECNLLQICKFTLKSCIFFFVKHVKKFKKQCCDCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TPE1</accession>
    <name>A0A433TPE1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_008869</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000246">
        <property type="protein sequence ID" value="RUS83366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TPE1"/>
    <dbReference type="STRING" id="188477.A0A433TPE1"/>
    <dbReference type="OrthoDB" id="6124591at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="151"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS83366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="346" mass="37850" checksum="3A399BB1907A26ED" modified="2019-05-08" version="1" fragment="single">MSTLKEDCETKKGAEENGFINTHESFTKETQDMDNLFMKLGDPGRLQLVWFFLLASSLLSVSPNSVVGVFFGYSPAHVCNASVDWSLSRQEFNLNRTGFYDVSDQVNFNSASFLYSQSLVRPNVSNTNVLPLAGLNGTDRELGIVQYGACSVNLTFNASAYPGVQTTTLSRSCEGGEWVYDISGREATTVTDFDLVCERRFLTALASSLYYLGLILANATLVYASDVLGRRPVVLLTLHLILVTGLGIAFAGSFLVFAVLRVLMGVLTQGLQSAAFVMAIELFPVHHRGRAGSAYQLVWGLGCLYLSGVAWLAQDWRAIQLAMLLPTALGALSMWYVGESLRWLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TQ20</accession>
    <name>A0A433TQ20_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6451 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_008564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000235">
        <property type="protein sequence ID" value="RUS83658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TQ20"/>
    <dbReference type="STRING" id="188477.A0A433TQ20"/>
    <dbReference type="OrthoDB" id="6242193at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045609">
        <property type="entry name" value="DUF6451"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF25">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20049">
        <property type="entry name" value="DUF6451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6451" evidence="1">
        <location>
            <begin position="42"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS83658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="211" mass="24834" checksum="EA15CC3889139634" modified="2019-05-08" version="1">MLRLHEEDIKEANKFTYLGSIVNKDGGSDEDIKCRINKARQAFITLRQIWKSKTLSIHNKLRIFNTNVKSVLLYGSETWRVTKTNSKKIQGFTNRCLRNILGVHWPEVISNEELWERTRQTPVETEIMKRKWGWIGHTLRKPASNITRQALDWNPQGKRKVGRPKQSWRRSVEEEVKASGTTWAELKRTCQNRVRWRSFVEALCSSRNQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TQW4</accession>
    <name>A0A433TQW4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_008302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000224">
        <property type="protein sequence ID" value="RUS83947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TQW4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS83947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="134" mass="14681" checksum="99C5BDF4E3000933" modified="2019-05-08" version="1">MSVLYCTSLSLRSEICGTMSVLYCTSLNLRSEICGTMSVLYCTSLNLRSEICGTMSVLYCTSLNLRSEICGTMSVLYCTSLNLRSEICGTMSVLYCTGLNLRSEICGTMSVIHCTSLNLRSEICGTMSVRTDHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TTA8</accession>
    <name>A0A433TTA8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_007469</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="RQTK01000193">
        <property type="protein sequence ID" value="RUS84785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TTA8"/>
    <dbReference type="STRING" id="188477.A0A433TTA8"/>
    <dbReference type="OrthoDB" id="1431934at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS84785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="153" mass="17264" checksum="46C8F8A1BB43A2B4" modified="2019-05-08" version="1" fragment="single">PDMCGGCLKSSDIEGSSKLMALGACSHWFCEHCWKSRLLRQTNKENASQEGVVFCVEEGCNNIVDSMTLLSLLNVKKIRSIFECKVRELVSALEPKTIYCPNESCRQIFSMLGNSPRTAEMAIPIVCRCSRQFCSMCFKSPHWPALCNHITRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TTF7</accession>
    <name>A0A433TTF7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycosyl hydrolase family 31 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_007443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000192">
        <property type="protein sequence ID" value="RUS84828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TTF7"/>
    <dbReference type="STRING" id="188477.A0A433TTF7"/>
    <dbReference type="OrthoDB" id="1334205at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF133">
        <property type="entry name" value="P-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="1">
        <location>
            <begin position="30"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS84828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="242" mass="26767" checksum="1CCE5ECECC94730F" modified="2019-05-08" version="1">MHTFFNTFLQYTYSCPPPTPSPLPVQPLFVFVCTRFPNDSQALDVDKQFMLGPALLVSPVLTQGASNVTAYFPEGQWYDYLTGEAATPGTVTLDTPLDKFNLHIRAGHVIPWQEPDVTTVKSRQKNLGLLVALGPSGRASGSLYWDDGESGVSENPPNFNLIKFDISRAGELTIRPEVVGLNTTLVFDTVELYGLRRLPTRVTVNGVEVPAERTSIVNTNIFKWTGLNLPMTSEATIRWTAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TU78</accession>
    <name>A0A433TU78_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_007119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000181">
        <property type="protein sequence ID" value="RUS85114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TU78"/>
    <dbReference type="OrthoDB" id="6080945at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS85114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="37863" checksum="4B57367A7EACA2D4" modified="2019-05-08" version="1">MLSYRLDNHTVSSDIAEFHAMLLFRVCVCTPLSVWSVLTGVVNVITYYRMGLRDGVNQNFFILSAADALQGVNTMADTIWNILGLVTKLDSSLVIHSLLTAAYSFPMGVSIITTTVIAVVRCCCVSMPFSVQRTLTASKQLAAILFLSGDFTAVIIYTSMDIQLFPSSPDDSVFKSKPVSQIWDSARLTLVFASFAIIVISMIILICALKKSSRLHRGFDADSSFTLSYIRSVRDRRIIKGIFLILALFVICYSTKIIIAILKIVSVKSGQLRQGTKSRCTVSGQNHVKFSDVKLEIRPQYVLAADIGVPHFRLLTASQLFFGKQRAVEMINKICLVSNCKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TUR2</accession>
    <name>A0A433TUR2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_006954</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000175">
        <property type="protein sequence ID" value="RUS85307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TUR2"/>
    <dbReference type="STRING" id="188477.A0A433TUR2"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS85307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="259" mass="28686" checksum="F74F011DCE4C4FF3" modified="2019-05-08" version="1">MCWGMTASRHGSPQSPGSNLHPYGTHLTANKVPNSRLGVCSEAQVKRLGKIDTFVNIPVTVKAHRSLNSSRGVVRSRDLETTSEEEMVEELDGVTHARRIFVRNPLTLKFTPYIPRPMRCFKCHRFGHSQTTCRRTAVCCRCGKGGHAGKDCKADHSCLNYHGPHATDLKECPKWKEEEAIQRYKAQHGGTFAQARAAIVVELDPNIKRRTYTKTTSVGTKITQTAPPKGSDRVNSTVKAQGAKSHKTDSPVKKAENLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TVS2</accession>
    <name>A0A433TVS2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_006540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000162">
        <property type="protein sequence ID" value="RUS85664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TVS2"/>
    <dbReference type="OrthoDB" id="6159454at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF124">
        <property type="entry name" value="FI05614P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019278003" description="FAS1 domain-containing protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="253"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="380"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS85664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="600" mass="66833" checksum="2198D3152318FEAA" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TVV0</accession>
    <name>A0A433TVV0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EGW08_006538</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">EC2010</strain>
            <tissue evidence="16">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="13">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000162">
        <property type="protein sequence ID" value="RUS85662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TVV0"/>
    <dbReference type="STRING" id="188477.A0A433TVV0"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000007">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="14">
        <location>
            <begin position="129"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="15">
        <location>
            <begin position="318"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RUS85662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="454" mass="50643" checksum="E120785C83A99CF5" modified="2019-05-08" version="1" fragment="single">IPDPLVSYSDARVCVPAHPTPRGARFRVKVAQRIGEFSRALHFEARAAIWVPALTCVKLAAVEPAQFSTRQANHSDSIAMRECISIHVGQAGVQIGNACWELYCLEHGIQPSGHMDDLRAATSFGDESYNTFFSETSMGKHVPRAIYVDLEPSVVDEVRTGAYRQLFHPEQLINGKEDAANNYARGHYTVGKEQIDLVLDRIRKMADPCTGLQGFLVFHSFGGGTGSGFSSLLMERLSVDYGKKSKLEFAVYPAPQVTICPVSLFLPKPVNHSHSQTRILSFPRRNLDIERPSYKNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLVTYAPIISAEKAYHEQMSVAEITNACFEPYNQMVKCDPRHGKYMACCMLYRGDVVPKDVNVAIASIKTKTSIQFVDWCPTGFKVGINYQPPTIVPGRSWRWGQHGPHLAEVGWFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TW97</accession>
    <name>A0A433TW97_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sushi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_006417</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000159">
        <property type="protein sequence ID" value="RUS85788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TW97"/>
    <dbReference type="STRING" id="188477.A0A433TW97"/>
    <dbReference type="OrthoDB" id="6159920at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050350">
        <property type="entry name" value="Compl-Cell_Adhes-Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19325">
        <property type="entry name" value="COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19325:SF575">
        <property type="entry name" value="LOCOMOTION-RELATED PROTEIN HIKARU GENKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="137"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="195"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="255"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="332"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="452"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS85788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="519" mass="55252" checksum="11307F33A54B7689" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TX08</accession>
    <name>A0A433TX08_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_006082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000149">
        <property type="protein sequence ID" value="RUS86134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TX08"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS86134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="234" mass="28185" checksum="59F8D08C3E9397DF" modified="2019-05-08" version="1" fragment="single">MELEYEIKLREDEAKKSKAEADEKRKQAEEERQKEKERKEKEEAERIAGLIKKEKDRMEEEARQAELKKRKEEEEEQRKVEEKKQKEEEKKRKEEEKRMKEEEKKRQKEEEKKRKEEEKRKKEEDKRKKEEEKKTKEEEKRRQKEEENKNILTVNQEVEIVQSQKVPDQISGKSESSKLYESFITQENTIIKGENETIKKTDGRVDTKDTEDAVGISSAELLVSSKHSDSDNNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TY67</accession>
    <name>A0A433TY67_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_005713</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000136">
        <property type="protein sequence ID" value="RUS86521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A433TY67"/>
    <dbReference type="OrthoDB" id="6163007at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051644">
        <property type="entry name" value="TRAMP_AT-DNA-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543:SF2">
        <property type="entry name" value="AGAP013096-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="69"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="189"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="529"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="591"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="990"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1302"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1501"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="939"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="610"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="624"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="638"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="701"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="755"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1007"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1302"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1362"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1392"/>
            <end position="1402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS86521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1570" mass="168527" checksum="AF88E63AC9402E72" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TYH9</accession>
    <name>A0A433TYH9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dynein axonemal intermediate chain 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">WD repeat-containing protein 78</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_005637</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Dynein axonemal particle</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000133">
        <property type="protein sequence ID" value="RUS86621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TYH9"/>
    <dbReference type="STRING" id="188477.A0A433TYH9"/>
    <dbReference type="OrthoDB" id="10259804at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120293">
        <property type="term" value="C:dynein axonemal particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001248">
        <property type="entry name" value="WD repeat domain 78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF12">
        <property type="entry name" value="DYNEIN AXONEMAL INTERMEDIATE CHAIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="730"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="773"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="310"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="458"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="873"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="384"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="885"/>
            <end position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS86621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="897" mass="99211" checksum="F4CE477C2414694A" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U0N1</accession>
    <name>A0A433U0N1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_004920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000114">
        <property type="protein sequence ID" value="RUS87308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U0N1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS87308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="206" mass="23843" checksum="22E6D4776B0F9F86" modified="2019-05-08" version="1" fragment="single">WFLAFLSTWSAVCLLSCLLGHFFGCCLVTSSVGYLLTYLLTWSVKWLVSCFLAYLISWLVACLPAYLLTWSVGWLLAYLSIFPSNLLLRLLLLLLLLLLLLLLLMMMMMVWLLFLLLLLLLLLLLLLLLLLLLLLFLLLLLLLLLLLLLLLMMMMMMMMMMMMMMLLLFLLLLLFVVVVVVVVVVVVVVVVVFLQLNRCLKFQIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U0P7</accession>
    <name>A0A433U0P7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_004831</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000112">
        <property type="protein sequence ID" value="RUS87377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U0P7"/>
    <dbReference type="STRING" id="188477.A0A433U0P7"/>
    <dbReference type="OrthoDB" id="6107607at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF3">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019184205" description="Fibronectin type-III domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="26"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="124"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS87377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="316" mass="35109" checksum="66C2FA84F1F99011" modified="2019-05-08" version="1">MAGILRLVILLYATVCAVLGSLDELKPRITYFGFRHSTAFLVNWEKPRKLNDNEIVRYEVATWMKNFEDQKMIVSTSPNKTSLVVMSLAPYTEYIVQVTAVTRMGRGPPSDPSPVLTDTAPPTTPLGLTISQITPRSVSLQWEQPEIFYRSIDSYEVELFSGGLPLRTLSTEDTKITVEDLTPGQDIVVRLCAVTKSVFGNANYEGESVQISLRTPLEAMTRSSEIPTTTSSEPPSTRVTTMPPGTTPTTTSRPRVVRGRKVESLASRTALAKLNWLRTGTRDQLAQARLANLQAEVAILQKIKLELEIAKLRRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U1X8</accession>
    <name>A0A433U1X8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_004432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000100">
        <property type="protein sequence ID" value="RUS87833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U1X8"/>
    <dbReference type="OrthoDB" id="6140258at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019499324" description="WSC domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS87833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="29459" checksum="F0953CCB6A816D32" modified="2019-05-08" version="1">MIGKFFSVVLVAAVFAVNTEGSEVCRPEYPVHFISDSKQAINKGCYHSSSDSKVFPKESLFNLRSKIDWNQWVLTNNGIEIIRQCGQEAIVRNKAYFGVEFYGECYFGDTPDFSLSKVTVAENCTKLCGMEVGGASAMMVYEVAARVLSCPAISAGYFIDDTHWAWNMGCYAQSSASHVLPLGNVDNQSSKTNFVAYRAAGHAGDMVKICGQIAIQNGASFFGVENYGYCYYGNQPDKSDGEVACTPQKCIFDIGTKEHIVLYKVMDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U2Z9</accession>
    <name>A0A433U2Z9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lengsin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Glutamate-ammonia ligase domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_004100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. Does not seem to have enzymatic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Dodecamer. Interacts with BFSP2 and VIM.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000092">
        <property type="protein sequence ID" value="RUS88138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U2Z9"/>
    <dbReference type="STRING" id="188477.A0A433U2Z9"/>
    <dbReference type="OrthoDB" id="77835at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43407">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43407:SF1">
        <property type="entry name" value="LENGSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS catalytic" evidence="8">
        <location>
            <begin position="1"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00037583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS88138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="280" mass="31649" checksum="BD56E365611D4E08" modified="2019-05-08" version="1">MAVTQLVEDILMDLVESMKKIGIKIETVMQESSSGQFEMTFAVVEGIEAADMLADFKTAAYVYLQKKGLNVEFMTCLHPGLDSNGCHYNFSLWDSHGRNVFADLDDEEKLSTISRHWLAGMVEHAPAMVALMCPTINCFRRIGSEWAPQFANWAEENRMASFRVKIERGGNVYIENRLPSGACNPYLVLAGTLAAGMDGLRRKLVLPRPMDESLRLPPTLGDALIALEMDGLMREALGEKLVELFVHSKRTFEVDEFKAFGELSDEEMLLKEKEYYYHPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U311</accession>
    <name>A0A433U311_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_004033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000090">
        <property type="protein sequence ID" value="RUS88201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U311"/>
    <dbReference type="OrthoDB" id="6144240at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS88201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="476" mass="52451" checksum="12538A2CD5DA6CED" modified="2019-05-08" version="1">MKLGLLVNINYALDTRPTQSEVEKAIDQLSSGKAHGADGIPAEVYKHGGPLMCVKAKASAAFGRLRSSVWDCEGVSLTSKIKVYRAVVLSTLLHLVRAYCGLRRLPQVDINYALDTLPTQSEVEKAIDQLSSGKAHGADGIPAEVYKHGGPLMREKAKASAAFGRLRSSVWDCEGVSLTSKIKVYRAVVLSTLLYASETWTVYQRHAKKLYGADGIPAEVYKHGCPLMREKVTELFQTMWAQEPSPETSKTPLSYIFIRRKGVVSHATITEKYHFSAPTASSRCTKKTKVMYHIDDDIDGRIAKASAAFGRLRSSELDSEGVSRQAKSKSIELLSSLHCSSPICSHLVRACCGLRSLPQVDINYALDTLPTQSEVEKAIDQLSSGKAHGADGIPAEVYKHGGPMMREKVTELFQTMWAQGTIPQNFKDASIVHLYKKKGSRQSRNNHRGISLLARMVLNRLSPTLSRDCYRKVRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U3Q2</accession>
    <name>A0A433U3Q2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_003725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000081">
        <property type="protein sequence ID" value="RUS88467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U3Q2"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS88467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="395" mass="43553" checksum="722811427C2E8CED" modified="2019-05-08" version="1">MRRSRRETGQKEEEQEEVRAGGSKMRREKELEGVKAEGGRAEGGEAVGESRRKEKQEGGRLKGCKSEKGQREEEQEHGHKQLIAYYTSEGERARARETQRDGEIGALNRTDLDRLVITAIVCPRSRHSRVERCYCYGENRAPSAIATGRAEPPVLLLRGEQSPQCYCPEESKVPSAIATGREEPPVLLLRGEQSPQCYCYGKNRAPSAIATGRAEESRAPVLSYGKNRVPSAIATGRTEPPVLLLRGEQSPQCYCYRESNTPSAIAPRRAEPPVLLLQGEQNPQCYCPEESRAPSAIATGREEPPVLLLRGEHSPQCCCPEESRSPSAIATGREEPPVLLLRGEQSPQCCCPEESRASSAIATERAEPPVLLLRGEQSLVTTSTPETTYERVCLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U4B3</accession>
    <name>A0A433U4B3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_003614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000077">
        <property type="protein sequence ID" value="RUS88655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U4B3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS88655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="145" mass="15861" checksum="C14C04778D04AC86" modified="2019-05-08" version="1" fragment="single">PGDDFRGHPVRRAHHCVALALLSAELRAEAKVCEFHRANHAQQNVVALDVPVDDVSVVQELQGFEALATDGCDLALLHDGLRDNVVQMPDLNNTYFHDDPELVVVDVVAVEEVDDVLVAVELHDLDLGDDELLLGLVVQVHHLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U6F4</accession>
    <name>A0A433U6F4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SOWAHA-C winged helix-turn-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_002849</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000057">
        <property type="protein sequence ID" value="RUS89412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U6F4"/>
    <dbReference type="STRING" id="188477.A0A433U6F4"/>
    <dbReference type="OrthoDB" id="60433at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058889">
        <property type="entry name" value="WHD_SOWAHA-C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14491">
        <property type="entry name" value="SOSONDOWAH, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14491:SF7">
        <property type="entry name" value="SOSONDOWAH, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25877">
        <property type="entry name" value="WHD_SOWAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SOWAHA-C winged helix-turn-helix" evidence="4">
        <location>
            <begin position="4"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="74"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="256"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="81"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS89412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="341" mass="37440" checksum="EEF77D9D9028DCA4" modified="2019-05-08" version="1">MADFELDAVLDFMVSKGGRVRNHELVTHFKNFLNHPVHKAQNREKFKDYVNELATIKLDESGEKVLLLKRKYRPSSDGYNSSASNLSTASSVSLSTTSSSSRPAPKTSSQSDQRPSASDPDLLSARGHSGVAVSERKSQNEEKTDPRQESPRAQSEPPAASPSKPQNDADSVDGGGMSRIKVDEAMEVRMRQTDRLQPSASSSVASLVSTDSQMSTTSATSGKTSTDEENNVSVISVKDKIKNLNKIHSETDLGRPARMENNHAGHHKKWTRPSIPGEEDDDVSHSSSASYVTLSAEQREWMVVCSSAEYHEMNRLLSKNPGLAKLKDFTSWYTDISLQAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U6R7</accession>
    <name>A0A433U6R7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_002657</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000052">
        <property type="protein sequence ID" value="RUS89539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U6R7"/>
    <dbReference type="STRING" id="188477.A0A433U6R7"/>
    <dbReference type="OrthoDB" id="424503at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052391">
        <property type="entry name" value="E3_Ligase-Neurotoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24133">
        <property type="entry name" value="ANKYRIN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24133:SF40">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="207"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="665"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="339"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS89539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="825" mass="95950" checksum="AD68D11D238EDAB9" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U7G0</accession>
    <name>A0A433U7G0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_002483</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000048">
        <property type="protein sequence ID" value="RUS89780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U7G0"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS89780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="440" mass="48159" checksum="F9D909EF24F9D51A" modified="2019-05-08" version="1" fragment="single">LCLVFLLPRVLLLKHSLYKAKPQVGALVLLLGQEGHDLVSQHIAQVFAQTRGQICLGQAGTQTVLRRNLGVLASTVLGDFPKHADGPLSGFSRRPDDALEVEQVLHGGVRVVVCRQPVLVGPEHPHHIRVLLFKPGRENEEEIWCVCLHFPCKSVHVIPDGAKPLAVVTEPDDDGVVECVGCLQIFQKLEVQLVAHKRLVVVVVCQPREETSLPVREEWRLVGLSAVVVVEKLQPVVVQFGYFRLVSEALLVLPHQVILDGFHHQGAHVVVHGLPVEAVPQVVKGCDDDLVEDNPSPVSQPPRVAPHERLIDLIHPAAGLELPLGVVGELLVGPACEKRHHVGRGGVAQLAVLVHLQPAKLLDEEVSSLWHGAGEVLLREAVYAKHENAEGFCRRVFVDVNFVAVAVDLLHVWVEPHHGEVRARDCLVVGVEAFHLDVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U7S0</accession>
    <name>A0A433U7S0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_002368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000046">
        <property type="protein sequence ID" value="RUS89838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U7S0"/>
    <dbReference type="OrthoDB" id="10020110at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="765"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS89838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="895" mass="97000" checksum="B0C7F34A98D1FA83" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U971</accession>
    <name>A0A433U971_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_001889</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000034">
        <property type="protein sequence ID" value="RUS90394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U971"/>
    <dbReference type="STRING" id="188477.A0A433U971"/>
    <dbReference type="OrthoDB" id="6154562at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000425">
        <property type="entry name" value="Myosin light chain kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000080">
        <property type="entry name" value="Myosin light chain kinase, smooth muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633">
        <property type="entry name" value="IMMUNOGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633:SF4">
        <property type="entry name" value="MYOPALLADIN ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="102"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="193"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS90394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="241" mass="27109" checksum="DE63DAACEC97E6E7" modified="2019-05-08" version="1" fragment="single">PVFTKPLRPVRVPESSAVTLEVHFKGIPPPVITWYRDNFEIQPSRDFQISTTETTSTLHVPEVFSEDAGLFTVKAYNKFGMVQCKAKLTVEERETQEKEVPPEFRNLARDTKVIQGEPVTFDCQITGSPPPEVHWTKEGYPLPESPRWKFIKADDVHTMVIFEAQPLDAGVYACVAINSVGKATCTARLTVEKPEKPLPSPKSEPMLESEIEPPYVVEEPPMLDVEEGEPVRFCCTIKGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UA16</accession>
    <name>A0A433UA16_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_001549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000027">
        <property type="protein sequence ID" value="RUS90649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UA16"/>
    <dbReference type="STRING" id="188477.A0A433UA16"/>
    <dbReference type="OrthoDB" id="528704at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902636">
        <property type="term" value="C:kinociliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028790">
        <property type="entry name" value="MKKS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46787:SF1">
        <property type="entry name" value="MOLECULAR CHAPERONE MKKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46787">
        <property type="entry name" value="SYNDROMES PUTATIVE CHAPERONIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS90649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="382" mass="41435" checksum="B08093428E7E3580" modified="2019-05-08" version="1">MMFNLEKNKPEAAQLHVAPVDSPDNIRSLCAFLDLVGSCSGPDAGVHLIRNTCGGHLTMTSDSGRLFASLSLSRQILKLIVSSAQGHLREYGDGGKFLSFACLSLIKSTVQLPGEFTNRRAFCALNEQFVKLLSKYLNSQECSVIVNADLSNIQVLLAYTKSMLLARPLLNLVDTECNKICELIVKCFVESIPEPQQYPVREHADGIFIVGCPFEHSRGSRLLKGLLLEHPELPCVKGETGFNLMTADIASKNTEGNVSVLNKGIKVVLVTCSMSGDLEDIVSAAYEVTAEQAASVEALAIDKWAHFCEKLAQNQIGLLLCQKVIHPRLKILLKSKNVMAVDRLGSAVIPYIRDLTGAQPVVSVIADPALRGLQALSLGFGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UC05</accession>
    <name>A0A433UC05_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_000906</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000014">
        <property type="protein sequence ID" value="RUS91292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UC05"/>
    <dbReference type="OrthoDB" id="411451at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008467">
        <property type="term" value="F:[heparan sulfate]-glucosamine 3-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037359">
        <property type="entry name" value="NST/OST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605:SF65">
        <property type="entry name" value="GH20068P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605">
        <property type="entry name" value="HEPARAN SULFATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="6">
        <location>
            <begin position="64"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="active site" description="For sulfotransferase activity" evidence="3">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="286"/>
            <end position="290"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS91292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="328" mass="37590" checksum="82E5961E6B180442" modified="2019-05-08" version="1">MFKTQKFKVLLQVTSLAFVLGVVLNLFLYNSSVSSNIRKTLSRDGSGSLSRLISDGDDAQRRFPKALIIGFSKCGTTALRAFISLHPDIVSPLEEVRFFTLNYTKGMEWYRLKMPPSTKSQITIEKTPFYIMDREALERIREFNSTIRLIISVRDPIARLQSQYAHTFRNVLDPDDRPSFKAWCQGNANSDHVVRFVDYASHISAVYDLFHKSQVLVLSEEALEMDPLSVMKEAEAFLGLRASFTKYDFVFNQEKGFYCFNMSSPNYPNIINSVKLSESGCIGGGKGREHPEVDEDFFQELVKAIRPHNEHLFSLIGKRFDWDNFKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UCX9</accession>
    <name>A0A433UCX9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_000527</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000007">
        <property type="protein sequence ID" value="RUS91701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UCX9"/>
    <dbReference type="OrthoDB" id="10640139at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019145873" description="Fibronectin type-III domain-containing protein" evidence="3">
        <location>
            <begin position="34"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS91701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="56880" checksum="1ACEBE6EADCB2458" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UDG8</accession>
    <name>A0A433UDG8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transmembrane protein 216</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_000417</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000005">
        <property type="protein sequence ID" value="RUS91846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UDG8"/>
    <dbReference type="STRING" id="188477.A0A433UDG8"/>
    <dbReference type="OrthoDB" id="262535at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019184">
        <property type="entry name" value="Uncharacterised_TM-17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13531:SF0">
        <property type="entry name" value="GEO07735P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13531">
        <property type="entry name" value="GEO07735P1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09799">
        <property type="entry name" value="Transmemb_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS91846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="17692" checksum="73B6E94F7797B5C8" modified="2019-05-08" version="1">MADGQAQAGTTTLIPRRGRTQVVRSSLPYQILLFLNGWYFAFFFVCEILLFVFKGETLPYASNVLAAEVILLFLLAAVEALRLFFGRRGNLTEQILGVLVCVILSVASVFGVLFVLLWQTYVLRVEVILAAIQLFFIGMEIIFGIISIITFANNDIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z784</accession>
    <name>A0A3S0Z784_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_020003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001094">
        <property type="protein sequence ID" value="RUS72230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z784"/>
    <dbReference type="OrthoDB" id="6435476at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="495"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="530"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="563"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS72230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="601" mass="65454" checksum="B9FA277AF2DD2649" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z8Q8</accession>
    <name>A0A3S0Z8Q8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_022833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001694">
        <property type="protein sequence ID" value="RUS69402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z8Q8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS69402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="399" mass="51292" checksum="8BBBC8553F1696A1" modified="2019-04-10" version="1">MYFEIKRRTLFSMKLYLLSVAPHGYPTAQRRRKKQKKKKKKEEEEKEEEEEKEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEKKKKKTMYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z987</accession>
    <name>A0A3S0Z987_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_019933</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001083">
        <property type="protein sequence ID" value="RUS72310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z987"/>
    <dbReference type="STRING" id="188477.A0A3S0Z987"/>
    <dbReference type="OrthoDB" id="10072198at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46670">
        <property type="entry name" value="ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46670:SF3">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018676360" description="Endonuclease/exonuclease/phosphatase domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="201"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS72310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="623" mass="71131" checksum="F79CCD94C05B9FF0" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z9G7</accession>
    <name>A0A3S0Z9G7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_018449</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000899">
        <property type="protein sequence ID" value="RUS73790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z9G7"/>
    <dbReference type="STRING" id="188477.A0A3S0Z9G7"/>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF349">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="10"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS73790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="233" mass="25619" checksum="0F56F0E60EDE817B" modified="2019-04-10" version="1">MKPVSSVDFTPQDPWTIPLFIGGAVFTVEGIAMILPIENRTRHPRDYTGPFGMVALATSTNVLLNLATGFYGYLAFGNSVSGNILVSLPSMWVYRLVSIMYATMVFLTFNLQLYQPAESIYAWLRRRVPSDFVEHHGNVATRTALVVLTFLFAALVPRVDLMMSLIGAFCAAFLVFVLPIVSELLLLHGEPGGVTWPIWVKDVFILMFGVTAFLTGTYTSVKDIGLALGKSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z9N0</accession>
    <name>A0A3S0Z9N0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">EGW08_019580</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">EC2010</strain>
            <tissue evidence="18">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001038">
        <property type="protein sequence ID" value="RUS72658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z9N0"/>
    <dbReference type="STRING" id="188477.A0A3S0Z9N0"/>
    <dbReference type="OrthoDB" id="432483at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000061">
        <property type="entry name" value="Potassium voltage-gated channel subfamily H member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003938">
        <property type="entry name" value="K_chnl_volt-dep_EAG/ELK/ERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003967">
        <property type="entry name" value="K_chnl_volt-dep_ERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050818">
        <property type="entry name" value="KCNH_animal-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217:SF637">
        <property type="entry name" value="EAG-LIKE K[+] CHANNEL, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217">
        <property type="entry name" value="VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01463">
        <property type="entry name" value="EAGCHANLFMLY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01470">
        <property type="entry name" value="ERGCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="273"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="697"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="17">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="16">
        <location>
            <begin position="451"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="30"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="595"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="903"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1092"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="767"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="606"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="913"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="980"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1028"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RUS72658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1117" mass="124634" checksum="D41866A1567200F4" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZBG3</accession>
    <name>A0A3S0ZBG3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome c oxidase subunit 6B1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Cytochrome c oxidase subunit VIb isoform 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_021129</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001272">
        <property type="protein sequence ID" value="RUS71106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZBG3"/>
    <dbReference type="STRING" id="188477.A0A3S0ZBG3"/>
    <dbReference type="OrthoDB" id="1107506at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00926">
        <property type="entry name" value="Cyt_c_Oxidase_VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.140:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 6B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003213">
        <property type="entry name" value="Cyt_c_oxidase_su6B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11387">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018528251" description="Cytochrome c oxidase subunit 6B1" evidence="6">
        <location>
            <begin position="19"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS71106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="116" mass="14105" checksum="8E349F9679876D0D" modified="2019-04-10" version="1" fragment="single">IVLLILFWLCFCLSGCTLRLWFKRLSRSIDVEEPPVDPCKQFWHPGFDARFPNMNQTKRCWQNYVDYLRCQEVLGEDHEPCEYFKKTYTFLCPGFWIQNWDDQVANGVFPRRKYHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZEJ6</accession>
    <name>A0A3S0ZEJ6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_016468</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000713">
        <property type="protein sequence ID" value="RUS75763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZEJ6"/>
    <dbReference type="OrthoDB" id="6271941at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050801">
        <property type="entry name" value="Ca-Dep_Lectins_ImmuneDev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801:SF63">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801">
        <property type="entry name" value="LITHOSTATHINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14295">
        <property type="entry name" value="PAN_4"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="174"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="375"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="610"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="913"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="695"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="703"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS75763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1044" mass="117089" checksum="0A78F75690EBDF0D" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZG83</accession>
    <name>A0A3S0ZG83_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Peptidase M14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_014067</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000527">
        <property type="protein sequence ID" value="RUS78179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZG83"/>
    <dbReference type="STRING" id="188477.A0A3S0ZG83"/>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000084">
        <property type="entry name" value="Carboxypeptidase B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.340">
        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057247">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036990">
        <property type="entry name" value="M14A-like_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF143">
        <property type="entry name" value="SLL0236 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00133">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018639797" description="Peptidase M14 domain-containing protein" evidence="12">
        <location>
            <begin position="30"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="13">
        <location>
            <begin position="134"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS78179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="453" mass="50905" checksum="39E47AAE95839C41" modified="2019-04-10" version="1">MRPTMSGFGPILLLVLVGYFAVLPRPSVALSYEGYQMYSVEVKTMKEVDNLINIIEQFDGVTTMNEPRYGKITLAVPTAMVSLLRSAFTDLNMEMTLVYNDIQRLIDATTKRPEGGIDKRSMVSTDTSVVDHEKYHRYPEIVSMLHHLASRNSDIMDVSTLVYRTHEGNQVICVKLHGNSSTSGSGASTKPAIVIESGIHAREWITPAVQLWLIENMLQGYRTGDPTVTTMLDTFDWYIIPVTNPDGYDYSHAVDRLWRKNRRYISYECRGVDLNRNFDVKFNTTGVSQNCRSNIYLGFKPFSEPETSNVKELVTSLRSRLVAYLAIHSYSQLILIPWGYSEEPMFPDNYDYLDHIAELMTVAISARHGVTFLKGQAYPLLGNAASGAGEDWALKEVPGIFATCIELRPSGDDVRGFLLPPDEIVPSAEEYFDSLVVMAMELAKQARDKNSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZHK2</accession>
    <name>A0A3S0ZHK2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endoplasmic reticulum junction formation protein lunapark</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_013168</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Plays a role in determining ER morphology.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the lunapark family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000473">
        <property type="protein sequence ID" value="RUS79063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZHK2"/>
    <dbReference type="STRING" id="188477.A0A3S0ZHK2"/>
    <dbReference type="OrthoDB" id="1725934at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098826">
        <property type="term" value="C:endoplasmic reticulum tubular network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071788">
        <property type="term" value="P:endoplasmic reticulum tubular network maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903373">
        <property type="term" value="P:positive regulation of endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040115">
        <property type="entry name" value="Lnp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019273">
        <property type="entry name" value="Lunapark_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166:SF12">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10058">
        <property type="entry name" value="Zn_ribbon_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Lunapark zinc ribbon" evidence="4">
        <location>
            <begin position="406"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="254"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="446"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="694"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="287"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="305"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="339"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="455"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="518"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="550"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="609"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="643"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="659"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="719"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="760"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS79063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="830" mass="90910" checksum="2F24C6CC7F18E5DD" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZKR1</accession>
    <name>A0A3S0ZKR1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_012220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000415">
        <property type="protein sequence ID" value="RUS80012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZKR1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37917">
        <property type="entry name" value="PROTEIN CBG03580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37917:SF9">
        <property type="entry name" value="RHOPTRY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS80012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="214" mass="21913" checksum="2D7E890DD01048EC" modified="2019-04-10" version="1">MQRKPEKMAAPIHPLSDFIKILRAGKYRQGCLLGVRGGASVHSNAKGPTLADQMAVIALPTGHSTRWPRLGSDHGHYTLDRPCHPQDFHRFEVTGATWWNQRGLGGINAGLGGINARPGGINARPGGINGCPCGINARPGGINARPGGINARPGGINACPGGINGCPCGINARPGGINARPGGINARPGGINAHPGGINARPCGINERPGGINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZLS1</accession>
    <name>A0A3S0ZLS1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dermatopontin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_010322</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dermatopontin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000314">
        <property type="protein sequence ID" value="RUS81936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZLS1"/>
    <dbReference type="STRING" id="188477.A0A3S0ZLS1"/>
    <dbReference type="OrthoDB" id="5975249at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030199">
        <property type="term" value="P:collagen fibril organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026645">
        <property type="entry name" value="Dermatopontin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15040:SF1">
        <property type="entry name" value="DERMATOPONTIN-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15040">
        <property type="entry name" value="DERMATOPONTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14704">
        <property type="entry name" value="DERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018627402" description="Dermatopontin" evidence="5">
        <location>
            <begin position="22"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS81936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="20392" checksum="EA7754D1F0A992C7" modified="2019-04-10" version="1">MTTAALVLLAASTLAVQTAWAYRHVDYENDWDAPVNFECPEGQLLSTIYSYFSAYRADRRWYFTCRGPENYGNTYSSCEWSGWTNDFDAGAFYLCPPNTAIAGLASEHNNYFEDRRMKFKCCGHPDFKVGACQITGNINSLTYDADYSTPSGKAIAGWVSEHFNAKNDRYFNMIVCPYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZLX0</accession>
    <name>A0A3S0ZLX0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_011423</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000372">
        <property type="protein sequence ID" value="RUS80802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZLX0"/>
    <dbReference type="STRING" id="188477.A0A3S0ZLX0"/>
    <dbReference type="OrthoDB" id="444540at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043226">
        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000178">
        <property type="entry name" value="Calmodulin-2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051581">
        <property type="entry name" value="Ca-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34524">
        <property type="entry name" value="CALCYPHOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34524:SF6">
        <property type="entry name" value="CALCYPHOSINE LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="39"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="75"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="111"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS80802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="211" mass="23993" checksum="EE10D08196FE4F9A" modified="2019-04-10" version="1">MADMGKLNAELKAKANVNKAHAKNPLELVQAHFLSRGASGIKGAQRRFRIMDDDGSKSLSFEEFSKGIREVGVNMSKEQEYELFRVFDRDGQGTINFDEFLRTLQPKMSDRRRKLVEAAFIKMDKSGDGVVTVKDIAQAYNAKKHPKYLSGEWTDTKVYQEYLKTFEAEGHVDGIVTLEEFMSYYASIGCSIDNDAYFDLMMRNSWGDLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZN75</accession>
    <name>A0A3S0ZN75_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_010518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000323">
        <property type="protein sequence ID" value="RUS81711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZN75"/>
    <dbReference type="STRING" id="188477.A0A3S0ZN75"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053110">
        <property type="entry name" value="Ribosomal_L1-TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48162:SF1">
        <property type="entry name" value="RIBOSOMAL L1 DOMAIN-CONTAINING PROTEIN CG13096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48162">
        <property type="entry name" value="YALI0A06930P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS81711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="233" mass="26119" checksum="BF6873B7602B40FA" modified="2019-04-10" version="1">MIQKKPAEQQFSHRHNFKIQNCHEDYDDDNDDEDDDGDDDDDDDDDDDDDDDDDDVDDDDDNDDDDDNDDDDVNDVINYNAKLIILKSPCASPSISGVGVPALAGDGGHVSPGVEHRFPTKEVRVLSPGISPHTVWTEKTFCPPHTCWQFMVQRIEHSRSATATTSTTATEQKHWCPFWQMSQFGDEFVLQHSNGCIVPGLGEGGREVALRYNIGFRRRKSVVRVLAILLPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZNX6</accession>
    <name>A0A3S0ZNX6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_012908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000458">
        <property type="protein sequence ID" value="RUS79323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZNX6"/>
    <dbReference type="OrthoDB" id="6151368at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS79323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="281" mass="30587" checksum="7FEA630E87A148D3" modified="2019-04-10" version="1">MGNNSSSRFSHGVRDAVRACSGGKRRRRHRHASLTEEDDDEARLNTCDSEPLDRGDCGGHERAVSVSRAGSRTSSLAHLGVHDGKAEPKSSLPRGGGSGRHASVSPRLGSRRTSPRIQPRGFHQHQHLHTDTDIHPGVTYQSLGPGHASPALSPTPCCCNFPKSRAWLVDQESQTVTHPLACEETPPHQAPVLEAALSKEYIVKTYSIQHATPSPSPATQTKFADTPTGRKPRPSISPVTQTKFVRLEADTPIGLRSRSQHAQEWTPSPPSTLQIKKCKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZQN6</accession>
    <name>A0A3S0ZQN6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_011734</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAM187 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000387">
        <property type="protein sequence ID" value="RUS80513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZQN6"/>
    <dbReference type="STRING" id="188477.A0A3S0ZQN6"/>
    <dbReference type="OrthoDB" id="6434091at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039311">
        <property type="entry name" value="FAM187A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32178">
        <property type="entry name" value="FAM187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32178:SF6">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="175"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS80513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="564" mass="65958" checksum="847F23ACEE521A54" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZQP6</accession>
    <name>A0A3S0ZQP6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_008643</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000238">
        <property type="protein sequence ID" value="RUS83589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZQP6"/>
    <dbReference type="STRING" id="188477.A0A3S0ZQP6"/>
    <dbReference type="OrthoDB" id="421226at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017071">
        <property type="term" value="C:intracellular cyclic nucleotide activated cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030553">
        <property type="term" value="F:cGMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005222">
        <property type="term" value="F:intracellularly cAMP-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005223">
        <property type="term" value="F:intracellularly cGMP-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000002">
        <property type="entry name" value="Cyclic nucleotide gated channel alpha 1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.630:FF:000001">
        <property type="entry name" value="Cyclic nucleotide-gated channel alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000030">
        <property type="entry name" value="Cyclic nucleotide-gated channel alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.300:FF:000002">
        <property type="entry name" value="Cyclic nucleotide-gated channel alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032406">
        <property type="entry name" value="CLZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050866">
        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003938">
        <property type="entry name" value="K_chnl_volt-dep_EAG/ELK/ERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF11">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16526">
        <property type="entry name" value="CLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01463">
        <property type="entry name" value="EAGCHANLFMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="12">
        <location>
            <begin position="458"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="656"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="593"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="656"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS83589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="722" mass="82673" checksum="F6E7C4378DF6B60C" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZT16</accession>
    <name>A0A3S0ZT16_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_017678</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000820">
        <property type="protein sequence ID" value="RUS74553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZT16"/>
    <dbReference type="OrthoDB" id="10252017at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043:SF8">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="17"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="65"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="161"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS74553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="259" mass="27450" checksum="99CB926876E7343B" modified="2019-04-10" version="1" fragment="single">CLQECDPGYYGEGCTEICSDQCAGGNATCHHVTGSCDLGCLPGYHGDLCLHECDPGYYGEGCTEICSDQCAGGNATCHHVTGSCDLGCLPGYHGDLCLHECVAGQYGAMCSKSCSENCAGEDNSCDNVNGTCDQGCEPGYQTPCCDNKCDVGFYGTGCIKNCSEHCSGEDNSCHHVTGTCDLGCEPGYQGDLCADAILQEGKIEDSERNMFGPSLSFQTFIIILGCAVAVIAVVAVVASLYMFRLVLHFYFIICFWLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZVK6</accession>
    <name>A0A3S0ZVK6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_005219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000122">
        <property type="protein sequence ID" value="RUS86981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZVK6"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS86981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="264" mass="29624" checksum="B8A89D2502BF93EC" modified="2019-04-10" version="1">MWSPSDWCFFSVVSSGEWADKKEVGRGKGRGRGKGRDRGKGRGIRKGRDRGKGRGIRKGRDRGKGRDRGKGRGQRKRRGQRKRKGHNKRKGQRKRKGAEEKERAEEKGGAEEKERGKGKGRGGGKGRDRGKGRGQRKRKGQRKRKGQRKKKGHKKRKGQRKRKGQRKRKGQGKKKGAEEKERAEEKEGTKEKEGAEEKEGAEEKEGAEGKEGAEEKEGGRGKGKARGKGRGQRKRKGTEEKEGDRGKGRGRGRGLLNVTFTKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZVP5</accession>
    <name>A0A3S0ZVP5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Potassium channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EGW08_004368</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">EC2010</strain>
            <tissue evidence="16">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000098">
        <property type="protein sequence ID" value="RUS87890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZVP5"/>
    <dbReference type="STRING" id="188477.A0A3S0ZVP5"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000090">
        <property type="entry name" value="two pore potassium channel protein sup-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003092">
        <property type="entry name" value="2pore_dom_K_chnl_TASK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF291">
        <property type="entry name" value="IP11374P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01095">
        <property type="entry name" value="TASKCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="15">
        <location>
            <begin position="79"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="15">
        <location>
            <begin position="171"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="331"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RUS87890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="389" mass="43115" checksum="D439103AC6967CF3" modified="2019-04-10" version="1">MLTMKKQNIRTLSLIVCTFTYLLVGAAVFDALESEFEKSKKSDLLKEEMEFRRNYNMSDKDFETLRENIIRSVPYKAGTQWKFAGAFYFALTVITTIGYGHSTPQTIGGKIFCMFYALSGIPLCIVMFQSVGERLNTFVVFLVKHVRKCFRRSSTEVSQTHLIFITLNLSSVVLTAGAAIFSYWEGWDYIDAFYYCFITLTTIGFGDYVALQKNDMLTKKHEYVTFCLIFILFGLAVLSAAMNLLILRFLTMNTVDEKREEMEAAAAARGAVRLDGDVITANGSVVSGAQETPEYNDLISVCSCSCYNLRSRRKLPRYSVTQAPGKITHLLPMTQTGGGGARVSTGGGGSGASGEGGGTKNREDSHSITDDSVSYLANLQYLSKKRASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZWT7</accession>
    <name>A0A3S0ZWT7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CCDC92/74 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_007295</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000188">
        <property type="protein sequence ID" value="RUS84933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZWT7"/>
    <dbReference type="STRING" id="188477.A0A3S0ZWT7"/>
    <dbReference type="OrthoDB" id="2155209at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029422">
        <property type="entry name" value="CCDC74_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040370">
        <property type="entry name" value="CCDC74A/CCDC74B/CCDC92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039496">
        <property type="entry name" value="CCDC92/74_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14882:SF5">
        <property type="entry name" value="COILED-COIL DOMAIN CONTAINING 74A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14882">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING 74A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14917">
        <property type="entry name" value="CCDC74_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14916">
        <property type="entry name" value="CCDC92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC92/74 N-terminal" evidence="3">
        <location>
            <begin position="77"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Coiled coil protein 74 C-terminal" evidence="4">
        <location>
            <begin position="255"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="355"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS84933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="43462" checksum="7C2E4A053DAE6DF7" modified="2019-04-10" version="1">MIRQGIVQDRIHDLSNMNNPLPPLNTLPQWSRVNALDKSRYPKPFVKDSQLSLEAGQSAGMEDDDQMLAVTEMNPAQRIQYLERSLLFLRQQHSDVLHSLHEEVMGLKKENKELQFKIVMSQKAAQAMREERLKEKGEKKEGQDSEEAGAGDSSETSSYSKLLEDTEKSKAEEKNTEMKIVFLEEEVKELKHALRETRNRNQYLTQLLEQAEEQRKKQKEALDTMKYEMNQGDGGMSETAEQIASGGSPIQANGKPLTLQQCQAIIKHLQQTNERQAHELDRLKLDLRDVLYSHKWTPDAYLMAKAYIAEDDRREDEKGGSLPRIPLKNPTRKLPEIAYIRENVSLPALRQTVGNKAVERRKRTQVLQRAKLRPGAMPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZX96</accession>
    <name>A0A3S0ZX96_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_014728</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000575">
        <property type="protein sequence ID" value="RUS77516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZX96"/>
    <dbReference type="STRING" id="188477.A0A3S0ZX96"/>
    <dbReference type="OrthoDB" id="506498at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF4">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="5">
        <location>
            <begin position="62"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase type 11" evidence="5">
        <location>
            <begin position="258"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="4">
        <location>
            <begin position="479"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase type 11" evidence="5">
        <location>
            <begin position="631"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS77516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="941" mass="105556" checksum="4EE0B32D8A5047CD" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZXI5</accession>
    <name>A0A3S0ZXI5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_006717</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000167">
        <property type="protein sequence ID" value="RUS85509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZXI5"/>
    <dbReference type="OrthoDB" id="6076671at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS85509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="179" mass="20483" checksum="18D89B507C93CE24" modified="2019-04-10" version="1">MAYIDATDLHTRPRRPASSGEPAAILFAHGPRWSWRYQRNSLSERLDKRFMYQDQGPPLYQLRGAHYNMYSIPPRSDFHDFSRSFHYEPRQHNAPSYPNGTRAFPPGPPPAQVARFDVLLPPVVREPKTQKLHVPNQPDPASIKAWDKYRYLQGPPADTVVLNHRSHALQSSTLSCLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A1H4</accession>
    <name>A0A3S1A1H4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_011941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000400">
        <property type="protein sequence ID" value="RUS80303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A1H4"/>
    <dbReference type="STRING" id="188477.A0A3S1A1H4"/>
    <dbReference type="OrthoDB" id="6163015at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS80303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="301" mass="31686" checksum="F1BF50335CC9B63E" modified="2019-04-10" version="1">MSHGPVRDKEEEEKEAVGQAKDDCRPPCIDTALYPGSDHLMKAPLESVSVYCGQLVQVSTVRGFGPTVQANMRLYEVTLCGGVSEWVVSDDTVALSDTVAFSDTVALSDTVAFSDTVALSDTVAFSDTVALSDTLALIDTVVLSDIVARIDTFVFSDTVAFSDTVALSDTLALIDTVVLSDIVAHIDTFVFSDTVVLSDTVAFSDTVTLSDTVVFSDTVALSDTVALSDTVTLSDTVTLSDTVTLSDTVALSDTVTLRDTVTLSDTVALSDTVTPSARRKGGKWLRESVPASNSKAIIALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A2A1</accession>
    <name>A0A3S1A2A1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_011369</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000369">
        <property type="protein sequence ID" value="RUS80850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A2A1"/>
    <dbReference type="OrthoDB" id="10458629at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS80850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="246" mass="27810" checksum="136FE4DD165A0789" modified="2019-04-10" version="1" fragment="single">MRAKKVSIALDGLSGERSMRSWISQTIKVRVRGPRWLVTASLLALLLLTVYHWHSLHSHGAHSDSVDTRARHRATPVGDSLNTRLDLLSQAAMFRAERTRGRTEEVQASGFDRGDAGIQSAWDDRSQSDGRDDAESDDRRNDVEPAPAVPEIKVVKMTPAQRASLDAIMDDMSATKRNLMYSVFERYVLPGSPEVLQWKSKGHDRQDRPGYFRPGNWDWTMTKVGEYDPDLFSPPPGELPKQRFPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A630</accession>
    <name>A0A3S1A630_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dynein regulatory complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_008543</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DRC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000234">
        <property type="protein sequence ID" value="RUS83695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A630"/>
    <dbReference type="STRING" id="188477.A0A3S1A630"/>
    <dbReference type="OrthoDB" id="27917at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050576">
        <property type="entry name" value="Cilia_flagella_integrity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973:SF12">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS83695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="529" mass="61803" checksum="696F7BA607FAABEC" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AS01</accession>
    <name>A0A3S1AS01_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">RPB5 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_021807</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001410">
        <property type="protein sequence ID" value="RUS70431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AS01"/>
    <dbReference type="STRING" id="188477.A0A3S1AS01"/>
    <dbReference type="OrthoDB" id="248779at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1340.10:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.940.20:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1340.10">
        <property type="entry name" value="RNA polymerase, Rpb5, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.20">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00025">
        <property type="entry name" value="RNApol_Rpo5_RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014381">
        <property type="entry name" value="Arch_Rpo5/euc_Rpb5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005571">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036710">
        <property type="entry name" value="RNA_pol_Rpb5_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000783">
        <property type="entry name" value="RNA_pol_subH/Rpb5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020608">
        <property type="entry name" value="RNA_pol_subH/Rpb5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035913">
        <property type="entry name" value="RPB5-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007129">
        <property type="entry name" value="PRK09570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01191">
        <property type="entry name" value="RNA_pol_Rpb5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03871">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000747">
        <property type="entry name" value="RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53036">
        <property type="entry name" value="Eukaryotic RPB5 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55287">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01110">
        <property type="entry name" value="RNA_POL_H_23KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb5 N-terminal" evidence="9">
        <location>
            <begin position="5"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase subunit H/Rpb5 C-terminal" evidence="8">
        <location>
            <begin position="137"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS70431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="210" mass="24321" checksum="C662EEA200D229BB" modified="2019-04-10" version="1">MDDQHETYKLWRIRKTVMQLCHDRGYLVTQEELDQTLDGFKEQFGDKPSERKPGRSDLIVLVAHNDDPTDQMFVFFPDESKVGIKTIKTYCQRMQEENIMRAIIVVQSGMTPSAKQALVEMAPKYILEQFIESELLINITEHMLVPEHKVMTAEEKAELLARYKLKESQLPRIQQGDPVARYFGLKRGQVVKIIRSSGTAGRYVSYRLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AW37</accession>
    <name>A0A3S1AW37_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_023386</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001969">
        <property type="protein sequence ID" value="RUS68852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AW37"/>
    <dbReference type="STRING" id="188477.A0A3S1AW37"/>
    <dbReference type="OrthoDB" id="203339at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050181">
        <property type="entry name" value="Cold_shock_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11544">
        <property type="entry name" value="COLD SHOCK DOMAIN CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="2">
        <location>
            <begin position="33"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS68852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="205" mass="23067" checksum="0D5B9DABF0C98F51" modified="2019-04-10" version="1">MMARFEFSCSNSHSSTSASGRQQEVPDPVVAPRISGTVKWFNVRRGYGFIKPDYEAGDIFVHRSAIVNHPRNRQRSVGDGERVEFHVVKDGSRRLMAANVTGPGGSQVIGSPYAVEWKPPNRHRYTHHYQCDRQPRPGRQTSHVDPTHQLAERAEITRGQPTHPGLNDPQSQTQSRSRENATAGTITASWEDCIRYAARPNAYYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B617</accession>
    <name>A0A3S1B617_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cyclin-dependent kinase 5 activator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_011510</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin-dependent kinase 5 activator family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000376">
        <property type="protein sequence ID" value="RUS80724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B617"/>
    <dbReference type="STRING" id="188477.A0A3S1B617"/>
    <dbReference type="OrthoDB" id="7676799at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030426">
        <property type="term" value="C:growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016533">
        <property type="term" value="C:protein kinase 5 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061575">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000025">
        <property type="entry name" value="Cyclin-dependent kinase 5 activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004944">
        <property type="entry name" value="CDK5_activator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23401">
        <property type="entry name" value="CYCLIN DEPENDANT KINASE-5 ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23401:SF0">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 5 ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03261">
        <property type="entry name" value="CDK5_activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS80724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="34072" checksum="513E1E96EB6FFDEE" modified="2019-04-10" version="1">MGTVLSLSPPSRRPLNEDITNHNYGYEMLNNHKNVLGNVNMNVKEKSFKKHSIFLSALSWKKFTVNPKKKDKSLLKLSNSAYLNGNNKFDSNCNIENFNLNNNFQKSVSCYNLKAAPEEPAVPVKTTSIKKLERPPTPERTVIQASTSELLKCLGEFLKRKCKRLRWFEPADAIMWLRAVDRSLLLQGWQDIAFINPANVVFIFLLVRDLPSSEMLHEVDLQAYVLTCLYLSYSYMGNEISYPLKPFLVEENKDRFWDRCLCVVNKHSSAMLRLNRDPGFFIDVFKELKTYSPCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B6H1</accession>
    <name>A0A3S1B6H1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Hexosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_011274</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Golgi apparatus membrane</location>
            <topology evidence="1 11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="RQTK01000363">
        <property type="protein sequence ID" value="RUS80954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B6H1"/>
    <dbReference type="STRING" id="188477.A0A3S1B6H1"/>
    <dbReference type="OrthoDB" id="2139606at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008499">
        <property type="term" value="F:N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000001">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF376">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS80954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="412" mass="47149" checksum="0A9EDC520F6EE060" modified="2019-04-10" version="1">MQSQPGSVPSSGLFVSLNVMHYHRHRRLTPLRAKVLIRVSIGMFLALLLLFLVVYTVILIYVDKHFNPPLLRSPNSRKLKLKGRIAAAIGPKDVGYYEILPLSNEALLLLHNGAVGAKGDIFGENGHRKQVWNPSFYYTVNETLPQCRYQSLFRVLIISSPEHFDQRQAIRKTWCDPTNFPQVPEHAWHCVFLIGQTKNNNHTSMLKTEKAVHQDLLIGNYMDTYRNLTLKVLPGFTWSVNHCPCSFLVKTDDDCFVNAGLLYTFLLQHNTHTRGLYVGNIVLDQSKLKVNRGPRNRWAVSLKDYPGKYYPPYASGMGYILTTDVAQQLVTESNFVQPIPVEDAYVGIIMSRLTVKLTDSKRFQITQSGLSLCNYVYVFIVHHVTFEEQYVLLKKAQEAWLRCSHDSTMSNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B7C4</accession>
    <name>A0A3S1B7C4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_010737</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000334">
        <property type="protein sequence ID" value="RUS81509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B7C4"/>
    <dbReference type="STRING" id="188477.A0A3S1B7C4"/>
    <dbReference type="OrthoDB" id="6085656at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18913">
        <property type="entry name" value="bHLH-O_hairy_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000009">
        <property type="entry name" value="Transcription factor HES-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050370">
        <property type="entry name" value="HES_HEY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003650">
        <property type="entry name" value="Orange_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10985">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07527">
        <property type="entry name" value="Hairy_orange"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158457">
        <property type="entry name" value="Orange domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51054">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="18"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Orange" evidence="8">
        <location>
            <begin position="93"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="277"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS81509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="37381" checksum="8262A4430AD0F042" modified="2019-04-10" version="1" fragment="single">MQSHDRVSTTGTPGEGGGRKSSKPIMEKRRRARINASLAELKSLLLEAIRKEGARHNKMEKADILEMAVKHLRQIQRQQFTGEAGESCVSTRYQLGYQACAHEVSKYLDSNSDEEVELKTKLLNHLANCITSEVFPVQARPGVGADRTGGSTRLGGFSLVGPVSSSSSETQDAFLLTVPSVSSAATSASAPSSSLLSSSAIISSSLVVPPTSTATFLTSPLSHFLYSTSSSLSSALSASSASLSSGVSGNCSAPVIIPIPISPLSIGTVSPASAASGVLSPEKQGLQHHSGSQTAGNNNSSGNVSSTHSLDLSTVRISDDGTFKTLEQNPNNLNSNVDNGGIKVCKSLSMMSSSNVQGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BB40</accession>
    <name>A0A3S1BB40_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_012933</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000459">
        <property type="protein sequence ID" value="RUS79315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BB40"/>
    <dbReference type="OrthoDB" id="10022583at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35555">
        <property type="entry name" value="ENDONUCLEASE-REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35555:SF3">
        <property type="entry name" value="ENDONUCLEASE-REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="500"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="528"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="591"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="346"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS79315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="618" mass="68530" checksum="DBCDF835907BC06D" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BBB4</accession>
    <name>A0A3S1BBB4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_012163</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000412">
        <property type="protein sequence ID" value="RUS80085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BBB4"/>
    <dbReference type="STRING" id="188477.A0A3S1BBB4"/>
    <dbReference type="OrthoDB" id="7765170at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="349"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS80085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="54622" checksum="1491BC4A8F40F5BF" modified="2019-04-10" version="1">MSLGVASALLARKVALRTGKWTSEPIEINPGLPQGSPLSSVLFNIYTAGVAETDRQSGKTLKFADDIMVYEKGTDRIQTAQQLQTRLDEIAIWCEENNAIINPDKAQVLWCSLNNNIVHTPTPPITFKYEVIERETTLKYLGITFDRTLSFNQHIENVSRKVKKGIGAIKTMASAHIQQNVLFVMFQLLILSVLDYGLGCLTLSEANLLKLERLQNEAMRAVLGCTRDTHIICMRFLLDLSSVRIRHKLAQAKTYLRVMENPHHPLYPSLLTQKGTRIKRGKSWMAEAEDSIKLVCPIEDIIDGREWIKTGPEQTALTKVIITMGRDRRECAAAVTEQDIRQLIHDNSKRHDPIIYTDGSVKRGIQSGWGFVCYSENRVIHEESGAAATTTSSMKMEIEAITKALEWIKLTRPTTTHAVFLTDSQSALKKIECGFMRMKWMTAIRPTAISSITWIFCPGHAGVKGNERADKLAGNATGFHFLYKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BDJ5</accession>
    <name>A0A3S1BDJ5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein NRDE2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_013979</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NRDE2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000522">
        <property type="protein sequence ID" value="RUS78263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BDJ5"/>
    <dbReference type="STRING" id="188477.A0A3S1BDJ5"/>
    <dbReference type="OrthoDB" id="297219at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902369">
        <property type="term" value="P:negative regulation of RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013633">
        <property type="entry name" value="NRDE-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471:SF0">
        <property type="entry name" value="NUCLEAR EXOSOME REGULATOR NRDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471">
        <property type="entry name" value="TETRATRICOPEPTIDE-LIKE HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08424">
        <property type="entry name" value="NRDE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="25"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1205"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1212"/>
            <end position="1244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS78263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1244" mass="141597" checksum="F2A0ED4E3C0ABCDF" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BE67</accession>
    <name>A0A3S1BE67_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">KOW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_013518</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000493">
        <property type="protein sequence ID" value="RUS78731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BE67"/>
    <dbReference type="STRING" id="188477.A0A3S1BE67"/>
    <dbReference type="OrthoDB" id="1688503at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000009">
        <property type="entry name" value="60S ribosomal protein L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_uL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005756">
        <property type="entry name" value="Ribosomal_uL24_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01080">
        <property type="entry name" value="rplX_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11143">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L26 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16906">
        <property type="entry name" value="Ribosomal_L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="4">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS78731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="143" mass="16661" checksum="D9DE9D32F43318D2" modified="2019-04-10" version="1">MKFNKDVSGSRRKNRARHFNAPSHIRRKIMSAPLSKELRAKYNVRSMPIRKDDEVQVVRGHYKGQAMGKVVQVYRKKFVVYIERINREKANGATVHVGIHPSKTVIVKLKLDKDRKKILERKAQSRVRAMADKGKYTEETMES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BFR8</accession>
    <name>A0A3S1BFR8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_012478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000429">
        <property type="protein sequence ID" value="RUS79762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BFR8"/>
    <dbReference type="STRING" id="188477.A0A3S1BFR8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS79762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="321" mass="33838" checksum="22286FA499F758E5" modified="2019-04-10" version="1" fragment="single">NGCSKGGERQLGERQSEGRPSARTKKGSRRPERPRGKGVKNEPKGKVSRRPKGPAGPKGPEEKGPRKACDKKPEVASKKESRPSQRQKDEERRPGGRPGGRGRPRGPRGPRGPRGRGNRRGQRGPRGPRGRGRPRGPRGPRGRGRPRGARGPRHQRRPKGPRARGCLGCPGCPPGPPGPPGPPGPPGPPGPPGPPGPRGPPGRDCGKCSCRAVPGLCNHKPDPKQVTGGPPAGTKPTQTPVPEKPTDGPKPRAKNDAPKSKVAKEPVPVKVSVKKTKSKPKKVTDGPKPRAKNDAPKSKVAKEPVPVKVSVKKTKSKPSKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BK43</accession>
    <name>A0A3S1BK43_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_002133</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000040">
        <property type="protein sequence ID" value="RUS90091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BK43"/>
    <dbReference type="STRING" id="188477.A0A3S1BK43"/>
    <dbReference type="OrthoDB" id="20282at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22860">
        <property type="entry name" value="PDRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030482">
        <property type="entry name" value="PDRG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21162">
        <property type="entry name" value="P53 AND DNA DAMAGE-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21162:SF0">
        <property type="entry name" value="P53 AND DNA DAMAGE-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS90091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="131" mass="15006" checksum="6D0AE67D5DFBDFA1" modified="2019-04-10" version="1">MGDPVEAGRVLSHLAEIEVVAEEILSTRREIIDMDRQRNKTREAIRALQNQKKEDKVWLCNGNMFLKVENAKAVKMLSKDFEALDTEVSSSRARLKPQVKKLRDLEMKDELKGFGLVALTPEERKSVENLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BKH8</accession>
    <name>A0A3S1BKH8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_001930</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HEXIM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000035">
        <property type="protein sequence ID" value="RUS90332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BKH8"/>
    <dbReference type="STRING" id="188477.A0A3S1BKH8"/>
    <dbReference type="OrthoDB" id="10058500at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097322">
        <property type="term" value="F:7SK snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004861">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024872">
        <property type="entry name" value="HEXIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13469">
        <property type="entry name" value="HEXAMETHYLENE BISACETAMIDE INDUCIBLE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13469:SF8">
        <property type="entry name" value="HEXIM P-TEFB COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15313">
        <property type="entry name" value="HEXIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02094">
        <property type="entry name" value="HEXIMFAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="239"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="285"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS90332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="315" mass="35114" checksum="5A7598FA435A6AD6" modified="2019-04-10" version="1">MAEIDKAKRDNSVAEVQNGERKPKVETDADSGDGDDYSSGSDRSFEAEEAEHCRGDIELEQISHINHVVAERRKRRHGSHGSRRHKGGSRHKNRGFHPYSIDPKEEQQLQRKSQEIKEKENAAAVVRQEGESRFMNFPVAPFNSTQFLMDEHDSGSPAGMHKTDSFSKLSDDSGILHSLASTPAESHHDMVNLERKDKEFTDIYTTVHAESLQSLPKNELVKNYMNLEEKVAALQKKVAEAEQQKKQDDDSGEMKMEECQEGILGNEQSQCGMDIPALSVHSGEDFSQTTQDVTSLPTISVGDVQSSDSVTRSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BKT6</accession>
    <name>A0A3S1BKT6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_006174</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000151">
        <property type="protein sequence ID" value="RUS86081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BKT6"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS86081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="231" mass="26067" checksum="C27C58D01A3AC79F" modified="2019-04-10" version="1">MQFTTSGAFWSVGLSLTYKKKFRSDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDVCVMMMMMMMMMMVVVVVVVVVVVAVERCIDQRYTNSETVKRRDLGKSVIIHAVHMSRPEKLNGGYESLNTDALGSTQHFHIWETVLPFVILMQSIAISIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIISVVVIVTSAIKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BKU6</accession>
    <name>A0A3S1BKU6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EGW08_001618</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">EC2010</strain>
            <tissue evidence="17">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000028">
        <property type="protein sequence ID" value="RUS90621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BKU6"/>
    <dbReference type="STRING" id="188477.A0A3S1BKU6"/>
    <dbReference type="OrthoDB" id="6080847at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024862">
        <property type="entry name" value="TRPV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10582:SF2">
        <property type="entry name" value="INACTIVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10582">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="532"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="162"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="16">
        <location>
            <begin position="337"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RUS90621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="689" mass="78518" checksum="E12B3B700FE7BDF6" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BL80</accession>
    <name>A0A3S1BL80_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_005945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000143">
        <property type="protein sequence ID" value="RUS86301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BL80"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS86301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="110" mass="11905" checksum="DF0F0F9595D0DDE3" modified="2019-04-10" version="1" fragment="single">SCLTSIPSNSRETCLTSKASNPRETSLTSIPSNPREPCLTSKASNPRKPCLISIPSNSREPCLTSKASNPREPCLISILSNPRELCLISKLSNPREPCLTSLPSNPREPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BN24</accession>
    <name>A0A3S1BN24_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_004706</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000108">
        <property type="protein sequence ID" value="RUS87530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BN24"/>
    <dbReference type="STRING" id="188477.A0A3S1BN24"/>
    <dbReference type="OrthoDB" id="69221at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039015">
        <property type="entry name" value="ENDOD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21472">
        <property type="entry name" value="ENDONUCLEASE DOMAIN-CONTAINING 1 PROTEIN ENDOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21472:SF7">
        <property type="entry name" value="ENDONUCLEASE G, MITOCHONDRIAL-LIKE ISOFORM X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018658179" evidence="2">
        <location>
            <begin position="22"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="677"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="684"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS87530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="783" mass="86685" checksum="E36FE3B2EDB18347" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BNP3</accession>
    <name>A0A3S1BNP3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_004351</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000098">
        <property type="protein sequence ID" value="RUS87873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BNP3"/>
    <dbReference type="OrthoDB" id="5983572at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058831">
        <property type="entry name" value="LolA-like_dom_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36902">
        <property type="entry name" value="ENRICHED IN SURFACE-LABELED PROTEOME PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36902:SF1">
        <property type="entry name" value="ENRICHED IN SURFACE-LABELED PROTEOME PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25898">
        <property type="entry name" value="LolA_2nd_metazoa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018770088" description="Apple domain-containing protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="867"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="657"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="748"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS87873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="899" mass="100812" checksum="A3CC21BF3E261B1D" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BPJ3</accession>
    <name>A0A3S1BPJ3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sulfatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_020498</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001168">
        <property type="protein sequence ID" value="RUS71733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BPJ3"/>
    <dbReference type="STRING" id="188477.A0A3S1BPJ3"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16029">
        <property type="entry name" value="4-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047115">
        <property type="entry name" value="ARSB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342:SF274">
        <property type="entry name" value="ARYLSULFATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="7">
        <location>
            <begin position="45"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS71733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="529" mass="59362" checksum="14038CF5AF7BF4F4" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BRG2</accession>
    <name>A0A3S1BRG2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_002560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000050">
        <property type="protein sequence ID" value="RUS89639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BRG2"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS89639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="172" mass="18949" checksum="767479113BD77753" modified="2019-04-10" version="1" fragment="single">SITRLTFPVTYDPAFLGGHVTAVGPRVGEALGARGALERFLSRVNANVLWWWKVMLEFECLAALRALELPQVGRLGVADHVTLQAIHIGKRFLTHLVERSQNKNQRSAKMQGQVLVQVRLKQERLLTPRALVARGLAGVSRTHVVAQETGPGEHALSIARWAVDTLQAVLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BRT4</accession>
    <name>A0A3S1BRT4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_002253</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000043">
        <property type="protein sequence ID" value="RUS89986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BRT4"/>
    <dbReference type="STRING" id="188477.A0A3S1BRT4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS89986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="497" mass="52045" checksum="F38AFF3C595A66A7" modified="2019-04-10" version="1">MALIYNKVNRTCKDDPLGHGTKRKKKTQALLLARGLTKALLLARGLTKALLLARGLTKALLLARDLTKVLLLARGLTKALLLARGLTKALLLARGLTKALLLARGLTKALLLARGLTKALLLARGLTKALLLARGLTKALLLARGLTKALLLARGLTKALLLARGLTKALLLARGLTKALLLARGLTKALLLARGLTKALLLARGLTKALLLARGLTKALLLARGLTKALLLARGLTKALLLARGLTKALLLARGLTKALLLARGLTKALLLARGLTKALLLARGLTKALLLARGLTKALLLARGLTKALLLARGLTKALLLARGLTKALLLARGLTKALLLARGLTKALLLARGLTKALLLARGLTKALLLARGLTKALLLARGLTKALLLARGLTKALLLARGLTKALLLARGLTKALLLARGLTKALLLARGLTKALLLARGLTKALLLARGLTKALLLARGLTKALLLARGLTKALLLARGLTKALLLATWLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BT23</accession>
    <name>A0A3S1BT23_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_001548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000027">
        <property type="protein sequence ID" value="RUS90648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BT23"/>
    <dbReference type="STRING" id="188477.A0A3S1BT23"/>
    <dbReference type="OrthoDB" id="6361347at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37159">
        <property type="entry name" value="GH11867P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37159:SF1">
        <property type="entry name" value="GH11867P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic" evidence="2">
        <location>
            <begin position="44"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS90648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="292" mass="33891" checksum="2B35A25DD5CF56C2" modified="2019-04-10" version="1" fragment="single">LEDGIAEDGDTGADLIPPRDFDMAKFYRGRQFFRDNLFSCCISMFYALILGLCFPDFLKTLIFTNNSETPRKAHKRYISTFKHIASWHYGDVWKEGSEAQKSILAVRKMHEKIRSEMAKNGCDHYLSQYNMVLVQSAFFAFPLMNTQQFGIQCSNASLDDYVYFWYGIGHLLGIDAKYNVCSRGMAQAKYFCENIRDEVVIPNLKNPSEDFYKMSNAIIVGWNRYLHNTVSVPYVIAFFLKLTNGESKRLGFVDMIRSIFWRLIFAAVRNMLSFKKFFNVAIERQFGLSFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BT35</accession>
    <name>A0A3S1BT35_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_001398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000023">
        <property type="protein sequence ID" value="RUS90891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BT35"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS90891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="118" mass="12561" checksum="021D84C9C945A943" modified="2019-04-10" version="1" fragment="single">SFPANTTAEQAPQRSFPANTAAEQAPQRSFPANTTAEQAPQRSFPANTAAEQAPQRSFPANTAAEQAPQRSFPANTAPEQAPQRSFPANTTPEQAPQRSFPADTAPEQAPQRSFPANT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BTZ4</accession>
    <name>A0A3S1BTZ4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_003592</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000077">
        <property type="protein sequence ID" value="RUS88633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BTZ4"/>
    <dbReference type="STRING" id="188477.A0A3S1BTZ4"/>
    <dbReference type="OrthoDB" id="413079at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23121:SF10">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23121">
        <property type="entry name" value="SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS88633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="43205" checksum="8B782345804D87BA" modified="2019-04-10" version="1" fragment="single">MASDQKQDYPNGSTVLTSNGENSNEYVTKPKNGKITLKNKEEELGQAEWIEQTTLHARDETVSFWKLFLDNSIYVITYCSVFGSFGVCVGFLGPTVFDLGCQTRSDMKQMNWVFFVQLIMTLVGSISAGLMAGKVPIHSLMLIGAVGVSLSMFLIPACGNLSSLIFVLVVMGWCMGCLDCLANLKIIQMFGKNVGPFLQAMHCSYGIGAFVSPMIASAFLLNKDCSKYIDGFTIETPSYHSMPTNESDLEPSTVTLHIPPQPHRVFRYRHMSRLPNAFYILGGLQLSIACLVAYVIVQEKSGRLKQRIVPGSGHEQMHHIGSPTQTDFKVGSMGGWFRQCCACGPRSVIMVTVITCVMLFVFDGLQSSFANYIYTYAHESGVTGLKRYEGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BXA0</accession>
    <name>A0A3S1BXA0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_001131</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000018">
        <property type="protein sequence ID" value="RUS91106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BXA0"/>
    <dbReference type="STRING" id="188477.A0A3S1BXA0"/>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000052">
        <property type="entry name" value="Lysine histidine transporter-like 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF703">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="35"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS91106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="447" mass="48243" checksum="5CF62FE471DDAEE1" modified="2019-04-10" version="1">MSELSETAGLIQPVFMLQPYDKVRGLSGAPPRAHGLTVFTTAVFAVGEMAGSGVLALPRALVATGWIGVVINIVCALASAYTGLLLGKCWLMVQGRYEEYKTNTRYPYPAIGFVTYGKVGRTIVSCSINLTLFGVSVVFLLLASENLQQLVKDAGKDISFCIWLLIAAAALCPTSWLGTPKDFWPIAVGATVATSIACIIIIANIAVDAENAPPTFHPDIDVKDFFMAFGTICFAFGGHPGFPTFQADMKEPQKFGKAIFLAYFILLLMYLPVAIAGYSVYGINADDNILLNLSGGPMQYIVEILITLHLFFGFVIVINPVCQEMEELVGIPTHFTFKRIISRTLIMVVVLFIAESIPHFGAILSLIGGSTTTLLAYILPPVFYLKLCSMEGDWEQQTPSLAQKVACFEIMLVGLVAGVASTYAAVDALATSSFSTPCYIDFHKAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C716</accession>
    <name>A0A3S1C716_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_007534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000196">
        <property type="protein sequence ID" value="RUS84706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C716"/>
    <dbReference type="OrthoDB" id="6162988at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="355"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS84706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="512" mass="57107" checksum="F756F8609D6929BB" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H2P1</accession>
    <name>A0A3S1H2P1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="9">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_021229</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="9"/>
    <dbReference type="EMBL" id="RQTK01001288">
        <property type="protein sequence ID" value="RUS71007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H2P1"/>
    <dbReference type="OrthoDB" id="6112700at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF54">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS71007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="484" mass="55967" checksum="59D54F6E0215D955" modified="2019-04-10" version="1">MSRLSRIFRRNPIPAVLVCTLTTVSLFVSISKFSEHGPSVKPPEDTALAVAGRVALEKQESLNANLLQLQKEFARVETELKYEKLRGQMLNKELEESKKKEFARVETELKYEKLRGQMLNKELEDAKKMLHKELEDAKKVRVWVGFGGFVGLTPPPPTTQQPKTPAEFFHREQERRLANILDVCSDTTRPFGVVNSLLPTEDGMTYCVIPRLTKDRLPEPRKFYGRGSKMLRSRRYRNPSEIFFAVQDPFKRLWETYVDNFRLPRKWNTNGIKIEAKRPPKKSAISEGKQLMKTCGMDVTFQEFVLFALKSYENEYDPFYRLCDPCQLKPTYVIRDESRQTDSRFVLQHFNLAWVLASSNFTRDEHLSYINNTEARKLKCATGGELGKRLWYALEVMGIIPGGTTSAPYIDDNTLPAQIIKIATDLFQVAEDRGMDRIAHKRKYLAEAFGSLPQHILDSVKKKYEMDFRLFGYERDPSDFEKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H5T7</accession>
    <name>A0A3S1H5T7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_019422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001014">
        <property type="protein sequence ID" value="RUS72817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H5T7"/>
    <dbReference type="STRING" id="188477.A0A3S1H5T7"/>
    <dbReference type="OrthoDB" id="7491348at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053121">
        <property type="entry name" value="Spore_Coat_Assembly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35365">
        <property type="entry name" value="LP04239P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35365:SF18">
        <property type="entry name" value="MUCIN-19-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS72817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="187" mass="20419" checksum="333134F4D82A3617" modified="2019-04-10" version="1">MYAWCGSVRYSALQCATVRYSAVQCGTVRDGAVQCETVRYSAVQCSTMRYSAVQCETVRYSAVQCETVRYSAVQCSRVRFRAGRCGTVRSSLVQCGAVRYSLVQCGTVWYSAVECGTVMCSAVQCGTVRYTAVQCGAVRCSAVQCGAVRYSAVQCGTVRYSVVKLWAVRYVTVQCETVRCGTEIVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HBA3</accession>
    <name>A0A3S1HBA3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_016437</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000710">
        <property type="protein sequence ID" value="RUS75810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HBA3"/>
    <dbReference type="STRING" id="188477.A0A3S1HBA3"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="468"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="120"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS75810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="706" mass="77684" checksum="A5ACF3E35056960A" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HDM9</accession>
    <name>A0A3S1HDM9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_014986</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000595">
        <property type="protein sequence ID" value="RUS77253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HDM9"/>
    <dbReference type="STRING" id="188477.A0A3S1HDM9"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="142"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="702"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="762"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="762"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="779"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="816"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS77253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="834" mass="91598" checksum="1ED9F1115AEE6E9A" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HLB2</accession>
    <name>A0A3S1HLB2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_010419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000319">
        <property type="protein sequence ID" value="RUS81827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HLB2"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS81827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="151" mass="16564" checksum="21FBABE2D1FE2FF0" modified="2019-04-10" version="1" fragment="single">LEVDVVLDLLDEVGHAGRDHVTLVQHLGELALEVRAQAVLRGHLALPDLGEHVLHALGPPHEVEHAQVHDLTLRGEHLRPHSTYGPDGSVHPVLQAEYVPARVPGRYVQQAYVQPAQDVRVVKLGVGGADRRLQDSSQVVQVQVAGWFRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HM43</accession>
    <name>A0A3S1HM43_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alpha/beta hydrolase fold-5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_010029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000297">
        <property type="protein sequence ID" value="RUS82215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HM43"/>
    <dbReference type="OrthoDB" id="188124at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029059">
        <property type="entry name" value="AB_hydrolase_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12695">
        <property type="entry name" value="Abhydrolase_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-5" evidence="1">
        <location>
            <begin position="84"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-5" evidence="1">
        <location>
            <begin position="343"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS82215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="725" mass="80077" checksum="CFB5C474C13AFE15" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HUH2</accession>
    <name>A0A3S1HUH2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_005886</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000141">
        <property type="protein sequence ID" value="RUS86368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HUH2"/>
    <dbReference type="OrthoDB" id="432281at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS86368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="309" mass="33528" checksum="2B048D8AE60A00E0" modified="2019-04-10" version="1">METSPITRSIIRGEHSLVLESLRQGEDANAVCSRTGQGYLHIICTHARGDSENAWVPMVYQLSNAGVDLNHRDRTGCTATWVAIRRKLVQVLAALLKCGAHLDTAELEEAEAGRGVTRNDMLEVVRRFSPGYWEAVLDPNPFKVSRLVKAWARVNISRRGTGQTLIEFAKQNARDGAVVGLLLQHEASIELAHAVMAGDAQRTTVLLCNGGADLATADFSVRVPALHAFAPLSLRGAAERYGHVNILKLLQDRETGGPKSASVSPTHKAVYDWSSWGSLSSKVPDYVCQGRTGNRSMANQTSSAMCTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SL04</accession>
    <name>A0A433SL04_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methanethiol oxidase</fullName>
            <ecNumber evidence="3">1.8.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_022423</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16007"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="EC" id="1.8.3.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Organosulfur degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the selenium-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.4" evidence="3"/>
    <dbReference type="EMBL" id="RQTK01001567">
        <property type="protein sequence ID" value="RUS69818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SL04"/>
    <dbReference type="STRING" id="188477.A0A433SL04"/>
    <dbReference type="OrthoDB" id="10252446at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018549">
        <property type="term" value="F:methanethiol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008430">
        <property type="term" value="F:selenium binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008826">
        <property type="entry name" value="Se-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23300">
        <property type="entry name" value="METHANETHIOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23300:SF0">
        <property type="entry name" value="METHANETHIOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05694">
        <property type="entry name" value="SBP56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0711">Selenium</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS69818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="432" mass="48540" checksum="B28BEB426FCCBF85" modified="2019-05-08" version="1">MAAQDRLKALSPALTSCCKGPGYPSPLEAMRSGAVEKIVYLPCIQPPQSRKNKPDYLATVDVDPTSPTYSKVIHRLLMPYNEDELHHSGWNACSSCHDDASRARNRLILPALNSDRIYIIDVGSDSREPKFHKIVEPSEVHSKTGMGAPHTTHCLGSGEVMISMIGDADGNATKSGFMLLDGKDFSIQGNWERSHIPMGYDYWYQPRHDVMISTEWGAPRAWRAGFNPKDVETGLYGHNLHVWRWSTHEKIQTIDLGQEGLIPLEIRFLHDPAQPMGYVGCALSSSVFRFYKTEAGDWAAEKVIQVPSKAVEGWALPEMPGLITDILISLDDRFLYFSNWLHGDIRQYDITDRRRPKLVGQVFLGGSIQSDGSVKVTKDTERTSQPEPVFVQGTRLEGSPQMIQLSLDGRRLYVTNSLFSAWDQQFYPEMVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SM25</accession>
    <name>A0A433SM25_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_022025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001463">
        <property type="protein sequence ID" value="RUS70215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SM25"/>
    <dbReference type="OrthoDB" id="6086695at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS70215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="696" mass="73378" checksum="88CCE084E472351F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SNR9</accession>
    <name>A0A433SNR9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_021342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001310">
        <property type="protein sequence ID" value="RUS70898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SNR9"/>
    <dbReference type="STRING" id="188477.A0A433SNR9"/>
    <dbReference type="OrthoDB" id="10066279at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS70898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="379" mass="47138" checksum="4FCD0A85239BD656" modified="2019-05-08" version="1" fragment="single">SRSQTRTWTELFSRSQTRTWTELFSRSQTRTWTELFSRSQTRTWTELFSRSQTRTWTELFSRSQTRTWTELFSRSQTRTWTELFSRSQTRTWTELFSRSQTRTWTELFSRSQTRTWTELFSRSQTRTWTELFSRSQTRTWTELFSRSQTRTWTELFSRSQTRTWTELFSRSQTRTWTELFSRSQTRTWTELFSRSQTRTWTELFSRSQTRTWTELFSRSQTRTWTELFSRSQTRTWTELFSRSQTRTWTELFSRSQTRTWTELFSRSQTRTWTELFSRSQTRTWTELFSRSQTRTWTELFSRSQTRTWTELFSRSQTRTWTELFSRSQTRTWTELFSRSQTRTWTELFSRSQTRTWTELFSRSQTRTWTELFSRSQTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SP31</accession>
    <name>A0A433SP31_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Rad21/Rec8-like protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_021244</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the rad21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001290">
        <property type="protein sequence ID" value="RUS70994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SP31"/>
    <dbReference type="STRING" id="188477.A0A433SP31"/>
    <dbReference type="OrthoDB" id="10071381at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21792">
        <property type="entry name" value="Rad21_Rec8_M_NXP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="entry name" value="Structural maintenance of chromosome 1. Chain E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049589">
        <property type="entry name" value="NXP1_M-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006909">
        <property type="entry name" value="Rad21/Rec8_C_eu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF69">
        <property type="entry name" value="FI11703P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04824">
        <property type="entry name" value="Rad21_Rec8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Rad21/Rec8-like protein C-terminal eukaryotic" evidence="7">
        <location>
            <begin position="556"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="446"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS70994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="609" mass="67992" checksum="B803051943965651" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SPV9</accession>
    <name>A0A433SPV9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_021055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001259">
        <property type="protein sequence ID" value="RUS71185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SPV9"/>
    <dbReference type="OrthoDB" id="6178696at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019217199" evidence="1">
        <location>
            <begin position="35"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS71185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="203" mass="23134" checksum="ADB910F38B8A51CC" modified="2019-05-08" version="1">MRHESCVSRVSQAVDKMKSLIAVAVLLLVSESLCEVCQAPQSESVFFLTSSLSDFYVANDFDNDRILIVWGADASSDHWSYLDLKNFITYINTAEGGCTYVHYTAAQNRIFERCLPEDAEQQRSGAVDFYTMERDEFTWLVGMKPVPDTDYFFRHFSRFYHEDVVAQEATFGVVYKYSLGISDPTIFDKDLSVCVEAPLAKYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SQC9</accession>
    <name>A0A433SQC9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CFA20 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_020766</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001206">
        <property type="protein sequence ID" value="RUS71467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SQC9"/>
    <dbReference type="STRING" id="188477.A0A433SQC9"/>
    <dbReference type="OrthoDB" id="10261083at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040441">
        <property type="entry name" value="CFA20/CFAP20DC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007714">
        <property type="entry name" value="CFA20_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12458">
        <property type="entry name" value="ORF PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05018">
        <property type="entry name" value="CFA20_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CFA20" evidence="2">
        <location>
            <begin position="3"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="426"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS71467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="713" mass="76558" checksum="396F995342C328E4" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SSH4</accession>
    <name>A0A433SSH4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanylate cyclase</fullName>
            <ecNumber evidence="2">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_020026</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="2"/>
    <dbReference type="EMBL" id="RQTK01001097">
        <property type="protein sequence ID" value="RUS72212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SSH4"/>
    <dbReference type="STRING" id="188477.A0A433SSH4"/>
    <dbReference type="OrthoDB" id="6127067at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008074">
        <property type="term" value="C:guanylate cyclase complex, soluble"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019934">
        <property type="term" value="P:cGMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070482">
        <property type="term" value="P:response to oxygen levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1520.10">
        <property type="entry name" value="H-NOX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.260">
        <property type="entry name" value="Haem NO binding associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038158">
        <property type="entry name" value="H-NOX_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011644">
        <property type="entry name" value="Heme_NO-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042463">
        <property type="entry name" value="HNOB_dom_associated_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655">
        <property type="entry name" value="GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655:SF6">
        <property type="entry name" value="HEAD-SPECIFIC GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07700">
        <property type="entry name" value="HNOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="9">
        <location>
            <begin position="549"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="18"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS72212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="681" mass="74148" checksum="A8AFD2FCE3FA4805" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T255</accession>
    <name>A0A433T255_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_016574</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="RQTK01000721">
        <property type="protein sequence ID" value="RUS75648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T255"/>
    <dbReference type="STRING" id="188477.A0A433T255"/>
    <dbReference type="OrthoDB" id="265776at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000018">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2230.10">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF76">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUSP" evidence="5">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="245"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="541"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="820"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="541"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="827"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS75648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="967" mass="110076" checksum="8E85144C03EF59A4" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T339</accession>
    <name>A0A433T339_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_016281</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM200 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000697">
        <property type="protein sequence ID" value="RUS75954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T339"/>
    <dbReference type="STRING" id="188477.A0A433T339"/>
    <dbReference type="OrthoDB" id="6162767at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018787">
        <property type="entry name" value="DUF2371_TMEM200"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31815">
        <property type="entry name" value="AGAP005329-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31815:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 200C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10177">
        <property type="entry name" value="DUF2371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS75954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="145" mass="16068" checksum="D6DCF0A3B0467337" modified="2019-05-08" version="1" fragment="single">MFVSHAKVRIVGLGGRSRKRRPHRRRLELREMAKMPCLMPTALTVLLGLLAVAFGAGMALLGYLPTMDAVVEVSKNISAVKRQMNTARYLTLQACSYAGPVVMAIGMFAMIMACVFYCEILDKYAILVPDKSHDSGLEKDELYQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T3S8</accession>
    <name>A0A433T3S8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Single-stranded DNA-binding protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_016006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000679">
        <property type="protein sequence ID" value="RUS76233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T3S8"/>
    <dbReference type="STRING" id="188477.A0A433T3S8"/>
    <dbReference type="OrthoDB" id="6158266at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04503">
        <property type="entry name" value="SSDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS76233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="23345" checksum="5A9C6676E83218DE" modified="2019-05-08" version="1">MNHPGGRMPGPMNPMYDSLQNYGVRGPPPPNSNMGPGGMPPLAMPGGPGPQNRWPPTSSSMNCASPANYTMNCTSPANFSINCTSPANFNDYVPQGPPQGGGPPGTPIMPSPQGEMRRTPTSYSPVIHDSGGPGDPMYMMKQGPPGMGGMQGFPMSGPDGPMGPMGPGDMPQVMNGDMDGMKNSPANGRGTPREDMPPVSSGGGGGGTGDMGPYGLGSYQDSVSQGLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T4C0</accession>
    <name>A0A433T4C0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_015835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000665">
        <property type="protein sequence ID" value="RUS76405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T4C0"/>
    <dbReference type="STRING" id="188477.A0A433T4C0"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051971">
        <property type="entry name" value="E3_ubiquitin-PDZ_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15545">
        <property type="entry name" value="PDZ DOMAIN CONTAINING RING FINGER PROTEIN 3, 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15545:SF8">
        <property type="entry name" value="SLO-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS76405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="302" mass="33931" checksum="17991D9D7AB56F2D" modified="2019-05-08" version="1" fragment="single">FISEVDPCSIAGKDGRIKEGDQIVQINGVDVRSRSEAISLFSGHGTDISLTVARAQLQCDDGFMEEPNMVLDELHMDLLEKHHHDNMQFMASMLARRHLDEEGGTTDTGTTENSSQKHEKDSGVGRTDESTRNDESSEHENFDSESLITPPSTASKMRHHSNDSFLSGSDIPAEGHPIGHRPLPPTPGRGDGARKGSESSLERELAILNREMEEIQVECQGLVDNHLRQQLQQQQQPHQPQQQQTQQQLLLQQQQHFLQLQGHPLLINSYNEAMLRPDLQKNSPRVVPRMGTRMEFSKYPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T7Q2</accession>
    <name>A0A433T7Q2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_014602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000565">
        <property type="protein sequence ID" value="RUS77627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T7Q2"/>
    <dbReference type="OrthoDB" id="6074207at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS77627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="463" mass="50074" checksum="0123E5B4565218E5" modified="2019-05-08" version="1">MSSMSSYKRKRIENWVEEVALYLRNGTICRSVIGHVAEDAINGTASDTGDSHQGAGGDGETAGTRSYQGSSSLTLSHKLDLAMKKSGPYGAALNGDGGKGVAGDGGVHNAFPVVKFAYSHYHEQRRKIDRLVQGLPVLNANGAASLDRSASRESGDEHAPIIFVNGEEPVRARAASQPRVLGIHHYGSSSNNFHHYSSSSNNFHHYSHAHVAAAPAVKHALQHQLQAPHTARHLAQPFRTPGAASFQQTPHDAIHNARRAAVASRTGTTARKLFGMPESRGSDVTVTVDPSLGMNATSNDRAARSKTAPSPNRNVHRARQRILTRRANNKVLEHSARSRSTAAGPWPNSPGDRAKQTHVTHSVLLTNTRYTLCYTLCVAHKHTLCCSQTHSVLLTNTLCVALCWRIPKLSVLVTTCSLLENTKVICAGDNSKLYTRSLLENTKVICAGDNSLFGGEYQSYLCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T9A2</accession>
    <name>A0A433T9A2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase M13 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_014126</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000532">
        <property type="protein sequence ID" value="RUS78118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T9A2"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF237">
        <property type="entry name" value="NEPRILYSIN-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="8">
        <location>
            <begin position="4"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="7">
        <location>
            <begin position="279"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="7">
        <location>
            <begin position="462"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS78118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="505" mass="57612" checksum="33E79D8BD3280DA5" modified="2019-05-08" version="1" fragment="single">FATELGADAQLAAQDAKAVVDLDSALAKILVPEEERRNFSSEYNPMTLAALGERYKFIDIPKAVRAIFATANLTVNDSQEVIVKYPAVLDRMAAVINSTDNRTLQNSFSFKYAYSRTNRLTKRLRDIALSMERILYGKTEEEPRSDMCVNKVIGVFPFGVGKEFIRKNFPEESKTYMNRMIDNLQAEFENQLHSATWLGQTTKAEAYRKLALMSRKIGYPDKDFSEEALDSKYENLTMAADRYYDNLETVRVQNSVASLLKLAEKTDKHEWNTGPHIVNAFYDYTKNSIFFPAGILQPPFFSAQYPDSLNYGAIGVVIGHEITHGFDDKGSQFDQDGNLRNWWQRQDMNNFHRARQCMVRQYSNFSDDNIKMNVNGITTQGENVADNGGLKQSYRAYKRLMAKTGEPKRLPGLGLTNDQTFFLGYAQLWCMKMTDAMKRLIMLKNSHPPGEFRFVIMKRLIMLKNSHPPGEFRILGPLQNSPEFAAAYKCPVGSRMNPETKCSVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TA31</accession>
    <name>A0A433TA31_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inositol polyphosphate 1-phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_013793</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000509">
        <property type="protein sequence ID" value="RUS78447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TA31"/>
    <dbReference type="STRING" id="188477.A0A433TA31"/>
    <dbReference type="OrthoDB" id="9977309at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004441">
        <property type="term" value="F:inositol-1,4-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.460.10">
        <property type="entry name" value="Inositol Polyphosphate 1-phosphatase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050725">
        <property type="entry name" value="CysQ/Inositol_MonoPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044897">
        <property type="entry name" value="INPP1_dom_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43028">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43028:SF3">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE 1-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS78447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="42306" checksum="3C92A433CB278110" modified="2019-05-08" version="1">MKASSLMQLFLEVAAKATEIATVIRKEKTLLDLLIEEKPDVKKNHQYFQDFKTLADVLIQETVHHFVSQKIPSLADSIYGEESNTFTNTKGDTITIEICHKQEETKALLKSILDGNDEAASLLSEAIHSSPEIQVASERLDVDIDTTDCGVWIDPIDATGQYIKGEIGVEDDNGITEDGLQCVAILIGMFQKSSGRPVLGVVVQPFAQWNHKTNSWTSNTVWGICHKELQETSFQASAINTDKQPMIVMSKSESEHVQSALSSKYKVVSASGAGYKILTTVLGLTNAYVLSHESIYRWDCCALHAVLLALGGGILSYRHAVQAASQAPGPLSRADLESLQLSYVKAAGAIASRRCSLPNSAESLPGIIAYKSADDAISILNLLKVKDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TCG5</accession>
    <name>A0A433TCG5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_012947</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000460">
        <property type="protein sequence ID" value="RUS79292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TCG5"/>
    <dbReference type="STRING" id="188477.A0A433TCG5"/>
    <dbReference type="OrthoDB" id="6151854at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050705">
        <property type="entry name" value="Cytochrome_P450_3A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302:SF15">
        <property type="entry name" value="FATTY-ACID PEROXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS79292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="11769" checksum="E9E86E2070F6FE9D" modified="2019-05-08" version="1" fragment="single">MNILDFFFNIPFWIVLIVIIVTLLYIYGTQTHSVWKDLGIPGPPPLPFLGNAHEIKRLGMPEAFREWGRSYGPVVGVYFMRRPMLVVSDVNMLKQILITDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TES6</accession>
    <name>A0A433TES6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipid-binding serum glycoprotein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_012185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000413">
        <property type="protein sequence ID" value="RUS80068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TES6"/>
    <dbReference type="STRING" id="188477.A0A433TES6"/>
    <dbReference type="OrthoDB" id="10255543at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.20.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032942">
        <property type="entry name" value="BPI/LBP/Plunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001124">
        <property type="entry name" value="Lipid-bd_serum_glycop_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504">
        <property type="entry name" value="BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504:SF131">
        <property type="entry name" value="BPI2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02886">
        <property type="entry name" value="LBP_BPI_CETP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00329">
        <property type="entry name" value="BPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipid-binding serum glycoprotein C-terminal" evidence="1">
        <location>
            <begin position="58"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS80068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="302" mass="33040" checksum="D96C60B331FA0CFD" modified="2019-05-08" version="1">MVGKASADLTKYFYVNYGLIEPPEVTSDYLQIQNKGTVYAKSRKMEPPFSPQVIPSSQDNSRMVYFWITQYSINTLLYQAHATGLLKYQITKAMLPPSDQPVLDMVCGQYCIGSAFPGLPPNDQPVLDMVCGQYCIGSAFPEVASRYQDYSVDVGLESTSMPRATLSTNRMTIEASVMVDFKLRSPSNRLSSLASLNVSASLTFAPSIRNDILGGRVQSPSLELSDVKLVGGKILNTPTVLDTILTKLFAIVVVPKLNVLTVQGFHLPGADGFSLRNAIVNVRPGYIMIGSDMAVHWFTFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TFS5</accession>
    <name>A0A433TFS5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_011851</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000394">
        <property type="protein sequence ID" value="RUS80386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TFS5"/>
    <dbReference type="STRING" id="188477.A0A433TFS5"/>
    <dbReference type="OrthoDB" id="546450at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000004">
        <property type="entry name" value="Tryptase gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="2">
        <location>
            <begin position="133"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS80386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="313" mass="33446" checksum="613BC72F4E406104" modified="2019-05-08" version="1" fragment="single">MIYQGTCLADILDCPKGNHGTYGQCSSGQICCFGPNPVSTGGSGTPSVTTTQAPSAHTMCQDLFGGTCLPDANNCPAGNHITVSFCGFRETCCFGPHSVSGSGGSGSGSTSGPATTLSGQSCGISMVNSNNRIVGGTEALSHEFPWQVSLMYNGHHMCGGTLIDAQWVLSAAHCFENTYRDQWRVAVGLHDKSTIYQRNYLAVMHVYSHANFDTTGANDNDIALLKLERPVDISGREVRTACLPSANENFDNQMCVVSGWGSRVEDGNSQRYLQKVSLPVLRNDLCNYWMGRNVVRPSMMCAGVRQGGKDACQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TG08</accession>
    <name>A0A433TG08_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_011712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000386">
        <property type="protein sequence ID" value="RUS80528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TG08"/>
    <dbReference type="OrthoDB" id="10062343at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS80528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="356" mass="39727" checksum="B7DE001F12AA54DA" modified="2019-05-08" version="1">MTAYWTASAGSFCQCQKFRWCHPGIHLTLDFVVRNGTGVLLEFFNAPGCLKSPADNHLATSDTSPLPDSLSDNVPELSSDPLLEVPVTPLPDLPVDPVPEVEADPLPCHTPDPSQKLPQKFYNCASKFKNLLRKKKASPSIHAHMVKNLANTRTPEKRRALDAIGLFKEKAKKTLFSGFSRPKARRPKLKEDRVATAVKVFYTREDISRILPHKQYSTRHGPAFVMNVTMLLAFRIFKEENSTTKVGYTKFTTLRPRIVRKLVTNATHLICLSKQGGETRVPVEGRLLGFMLCPKPESSKWHKPECLKGSCVICHNNMARFETLAEPICDDTIVKSTHFAKTQMTLHHGGGISQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TI82</accession>
    <name>A0A433TI82_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GDP-L-fucose synthase</fullName>
            <ecNumber evidence="4">1.1.1.271</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_010949</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.271" evidence="4"/>
    <dbReference type="EMBL" id="RQTK01000346">
        <property type="protein sequence ID" value="RUS81275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TI82"/>
    <dbReference type="STRING" id="188477.A0A433TI82"/>
    <dbReference type="OrthoDB" id="202470at2759"/>
    <dbReference type="UniPathway" id="UPA00128">
        <property type="reaction ID" value="UER00191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050577">
        <property type="term" value="F:GDP-L-fucose synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042351">
        <property type="term" value="P:'de novo' GDP-L-fucose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05239">
        <property type="entry name" value="GDP_FS_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00956">
        <property type="entry name" value="GDP_fucose_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028614">
        <property type="entry name" value="GDP_fucose/colitose_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43238">
        <property type="entry name" value="GDP-L-FUCOSE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43238:SF1">
        <property type="entry name" value="GDP-L-FUCOSE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="9">
        <location>
            <begin position="7"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS81275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="318" mass="35715" checksum="7438F77983285D91" modified="2019-05-08" version="1">MSDKKVILVTGGTGLVGRGIRAAVEREGPREGEQWHFVSSQDGDLRDRDATEALFDKIRPTHVIHLAALVGGLFRNLKYNLDIYRINSQINENVISTSHKYNVQKVVSCLSTCIFPDKTTYPIDESMIHNGPPHDSAFGYSYSKRMIDVQNKGYHMQHGRTYTSVIASNVFGPYDNFNPENGHVLPGLIRKAFDAKADGNPFVIWGTGSPRRQFIYSLDLGRLFLWILREYNDVTPIILAADEESEISIKEAADLVVNAVGFKGEVIQDTSKPDGPLKKTTSNAKLRRLLPDFQFTPIKQAIQETCDWYAANPDKVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TIJ3</accession>
    <name>A0A433TIJ3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_010903</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000343">
        <property type="protein sequence ID" value="RUS81336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TIJ3"/>
    <dbReference type="STRING" id="188477.A0A433TIJ3"/>
    <dbReference type="OrthoDB" id="10011262at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="74"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="355"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS81336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="410" mass="46163" checksum="C11D168EB87DEB81" modified="2019-05-08" version="1">MTTYMIADATPMMLFSNMSDLEPSEPGEHWDSLRSGEFSCAKNESQEYRQFYETTQMVCGLIVYPIMCIVGLTGNLLALVVLNHRDMRTSTNVYFSSLAVSDFIKLLNDLLYFVIVAIALTDPALGERMMSFVYPVAHYVFNMSVCVTAWLTVSVAVERYISVCHPSRAKQLCTIRRARNVCTCVFVLMSVLAVPSALRYEMRTVHDQVLNKTCVSVVQTALGRNDAFMVPYSWVQNSLRGIVPVFILVYLNVRIINELRKERVKGKKLNSRNRITLMLIVVVFMFLGCITPDAIMSTFFGKGYVEEDFLVKGIREITDSLLAVNSAVNFLLYISMSVLFRKTFLKIFCSFSRKPGKSPKTEAIKLNRKDPAPRNHGAVDEDDPDLVRGNGEAMRTPAVGDGEDCPEAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TIU6</accession>
    <name>A0A433TIU6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">EGW08_010786</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">EC2010</strain>
            <tissue evidence="19">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Synaptic cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000337">
        <property type="protein sequence ID" value="RUS81446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TIU6"/>
    <dbReference type="STRING" id="188477.A0A433TIU6"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19064">
        <property type="entry name" value="LGIC_TM_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000038">
        <property type="entry name" value="Acetylcholine receptor subunit beta-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000016">
        <property type="entry name" value="Nicotinic acetylcholine receptor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 15" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5022251226" evidence="15">
        <location>
            <begin position="24"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="491"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="17">
        <location>
            <begin position="33"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="18">
        <location>
            <begin position="250"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="413"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RUS81446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="547" mass="62658" checksum="A47C78734869C4A4" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TLE7</accession>
    <name>A0A433TLE7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Laminin subunit alpha-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Laminin-1 subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Laminin-3 subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">S-laminin subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">EGW08_009817</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">EC2010</strain>
            <tissue evidence="26">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="13">Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Alpha-1 is a subunit of laminin-1 (laminin-111 or EHS laminin) and laminin-3 (laminin-121 or S-laminin).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000287">
        <property type="protein sequence ID" value="RUS82429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A433TLE7"/>
    <dbReference type="OrthoDB" id="5984158at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048699">
        <property type="term" value="P:generation of neurons"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000090">
        <property type="entry name" value="laminin subunit alpha"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000388">
        <property type="entry name" value="Laminin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000069">
        <property type="entry name" value="Laminin subunit alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000189">
        <property type="entry name" value="Laminin subunit alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000034">
        <property type="entry name" value="Laminin subunit alpha 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000051">
        <property type="entry name" value="Laminin subunit alpha 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000209">
        <property type="entry name" value="Laminin subunit alpha 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000407">
        <property type="entry name" value="Laminin subunit alpha-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000092">
        <property type="entry name" value="Laminin subunit alpha-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000065">
        <property type="entry name" value="Laminin subunit beta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000105">
        <property type="entry name" value="laminin subunit gamma-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050440">
        <property type="entry name" value="Laminin/Netrin_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010307">
        <property type="entry name" value="Laminin_dom_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000034">
        <property type="entry name" value="Laminin_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008211">
        <property type="entry name" value="Laminin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574:SF406">
        <property type="entry name" value="LAMININ SUBUNIT ALPHA 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574">
        <property type="entry name" value="NETRIN/LAMININ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00052">
        <property type="entry name" value="Laminin_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00054">
        <property type="entry name" value="Laminin_G_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06009">
        <property type="entry name" value="Laminin_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00055">
        <property type="entry name" value="Laminin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="SMART" id="SM00281">
        <property type="entry name" value="LamB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00136">
        <property type="entry name" value="LamNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51115">
        <property type="entry name" value="LAMININ_IVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51117">
        <property type="entry name" value="LAMININ_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9 20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10 19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 19" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 21" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019475627" description="Laminin subunit alpha-1" evidence="21">
        <location>
            <begin position="28"/>
            <end position="3677"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin N-terminal" evidence="25">
        <location>
            <begin position="26"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="23">
        <location>
            <begin position="405"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="23">
        <location>
            <begin position="450"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="23">
        <location>
            <begin position="496"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="23">
        <location>
            <begin position="543"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="23">
        <location>
            <begin position="589"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="23">
        <location>
            <begin position="634"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="23">
        <location>
            <begin position="680"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="23">
        <location>
            <begin position="739"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="23">
        <location>
            <begin position="1398"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="23">
        <location>
            <begin position="1444"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="23">
        <location>
            <begin position="1488"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="23">
        <location>
            <begin position="1536"/>
            <end position="1586"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin IV type A" evidence="24">
        <location>
            <begin position="1598"/>
            <end position="1782"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="23">
        <location>
            <begin position="1816"/>
            <end position="1862"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="23">
        <location>
            <begin position="1863"/>
            <end position="1920"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="23">
        <location>
            <begin position="1974"/>
            <end position="2020"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="23">
        <location>
            <begin position="2021"/>
            <end position="2067"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="23">
        <location>
            <begin position="2068"/>
            <end position="2113"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="22">
        <location>
            <begin position="2687"/>
            <end position="2916"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="22">
        <location>
            <begin position="2929"/>
            <end position="3098"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="22">
        <location>
            <begin position="3105"/>
            <end position="3277"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="22">
        <location>
            <begin position="3319"/>
            <end position="3493"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="22">
        <location>
            <begin position="3499"/>
            <end position="3674"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="2441"/>
            <end position="2538"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="2660"/>
            <end position="2687"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="450"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="452"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="471"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="543"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="545"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="564"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="589"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="609"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="634"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="636"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="655"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="709"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="762"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="1398"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="1400"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="1419"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="1460"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="1511"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="1536"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="1538"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="1557"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="1835"/>
            <end position="1844"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="1891"/>
            <end position="1900"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="1993"/>
            <end position="2002"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="2041"/>
            <end position="2050"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="2087"/>
            <end position="2096"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3250"/>
            <end position="3277"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3647"/>
            <end position="3674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00065595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00075127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00078827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="RUS82429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="3677" mass="404278" checksum="FD35A4541ACC5E62" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TLH6</accession>
    <name>A0A433TLH6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_009763</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000285">
        <property type="protein sequence ID" value="RUS82457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A433TLH6"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF34">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="42"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS82457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="207" mass="22713" checksum="5DBC887DBE1BFDF7" modified="2019-05-08" version="1" fragment="single">RQRLLXADTANHRSPHRSAENGRPVTTYEDALAECGFGRYHIGLLLVCGWAVSSDAIEVLSVSFLLPSATCDLKLTSSDKGWLNATVFLGMMLGGYFWGSLSDKSGRRTVLMWSLLVNGVGNLGSSLAQKYWLFLLCRLISGIGVGGSMPVIFTYYTEFQHKSRRGAMISLLATFWMAGNIIAASLAWLVIPREYISFTLTYTSASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TME6</accession>
    <name>A0A433TME6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA-queuosine alpha-mannosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.110</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_009515</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>queuosine(34) in tRNA(Asp) + GDP-alpha-D-mannose = O-4''-alpha-D-mannosylqueuosine(34) in tRNA(Asp) + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12885"/>
            <dbReference type="Rhea" id="RHEA-COMP:18572"/>
            <dbReference type="Rhea" id="RHEA-COMP:18581"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:194431"/>
            <dbReference type="ChEBI" id="CHEBI:194442"/>
            <dbReference type="EC" id="2.4.1.110"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:12886"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.110" evidence="4"/>
    <dbReference type="EMBL" id="RQTK01000274">
        <property type="protein sequence ID" value="RUS82735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TME6"/>
    <dbReference type="STRING" id="188477.A0A433TME6"/>
    <dbReference type="OrthoDB" id="10032790at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016438">
        <property type="term" value="F:tRNA-queuosine(34) beta-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051862">
        <property type="entry name" value="GT-like_domain_containing_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022701">
        <property type="entry name" value="QTMAN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13615">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13615:SF3">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12038">
        <property type="entry name" value="QTMAN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="tRNA-queuosine alpha-mannosyltransferase N-terminal" evidence="9">
        <location>
            <begin position="10"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="8">
        <location>
            <begin position="307"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="267"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS82735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="483" mass="55725" checksum="06BF2A7A3065A389" modified="2019-05-08" version="1">MASNSTMKEVLLIEPFCGGSHGQLIQLLSTDKEIGPRCEQVCLPAKKWQWRARTSALYLSQVIPYSETFMVLFASSVLNLAELVALRPDLSRLKKILYFHENQLVYPVRKHQERDFQYGYNQILSSLVADVLVFNSTFNMESFLSSIPSFLKLIPDHRPKNLVSQIRPKCQVLYFPLDMKIVSNVSTQTNVESDKSKRRGQYPTVQRIKQEPADVELNSVLKTGSDDRVHSIEGAFNDHYTDIPFKMECYSDNSEYLKCQKEESTEKNQEQCAQNDQDPPLSALQSPSMTPESLSTGGKMFLKWDPHAINDHSLHIVWPHRWEHDKDPESFFAALFQLQQENLSFNVSVVGETFSAVPEIFNTARLTLGDRVKAWGFQSREDFLAILDSAHVVVSTAIHEFFGVSMLEAVARNCYPLCPNRLVYPEIYPREYLYSTHSQLVKRLKRFCHRPQSLNTSLCKDFIEKFSWEQLQEQYRRLILTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TQL5</accession>
    <name>A0A433TQL5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EGW08_008433</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">EC2010</strain>
            <tissue evidence="15">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000229">
        <property type="protein sequence ID" value="RUS83821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TQL5"/>
    <dbReference type="STRING" id="188477.A0A433TQL5"/>
    <dbReference type="OrthoDB" id="10025005at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000002">
        <property type="entry name" value="Potassium voltage-gated channel subfamily a member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003971">
        <property type="entry name" value="K_chnl_volt-dep_Kv5/Kv9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF252">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01494">
        <property type="entry name" value="KV9CHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="14">
        <location>
            <begin position="108"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="420"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RUS83821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="501" mass="56513" checksum="AF9A8AA2EE84242F" modified="2019-05-08" version="1" fragment="single">KQPIQLNSVLNSFTSAGELHVPLEVCGAVVKRELDFWQIAEDQIKACCWRHYRSYIENQRILNSFNRSLEHEQDTVDLSSLRGWKLLQMRLWLILDHPRTSRLAMMYGITSFLFVAASIAGFCLETLPGLRPELVPNKTHTSCGGGDQKKLHVMQTSNEALNVLDFTCTVFFTLELLLRFCVSPNKRRFVLSPMNIIDLLALVPLYVQVIFEQSNLQACYMNERFVIEIMFILRIFRMFRIFHLVKHYQALKVLVYALRASLQELLMLFIFLLIAMLIFSTMIYYAERSHDLGAGSNFPTIPIGFWWAIITMTTVGYGDVTPSTPVGYMVGTACSVCGVLLVALTFPVISNNFSLFYEHVRSRSLSPRKLDGSEEDLGIDGGETELLGFKRDQPNRDWKEGEDLGFLLDHPPLYGSVSLSMHHIPPSHSANQADHPRRHSHAGPSNQKPFAAAGASVDSNAKPEPATTIPTARDSRTSYIPLAKFSDSDIVLQNSTTEEAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TT56</accession>
    <name>A0A433TT56_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_007477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000193">
        <property type="protein sequence ID" value="RUS84793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TT56"/>
    <dbReference type="OrthoDB" id="6231385at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS84793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="133" mass="15052" checksum="1B76FE94BBE955D2" modified="2019-05-08" version="1">MAESFEEPGYAADENKEGYVRLRVKFDGLKVHSAGIIDRIRGRHPLPIGKNAEIENPTITERGFELIVRGAKAGAMKGAQYRLTINQLPYAIDPEETYLVGLEGFIDVFFKKYDENQSWEKAIREGNLETFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TU66</accession>
    <name>A0A433TU66_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA-(apurinic or apyrimidinic site) endonuclease</fullName>
            <ecNumber evidence="13">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EGW08_007115</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">EC2010</strain>
            <tissue evidence="16">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10 13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10 13">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="13"/>
    <dbReference type="EMBL" id="RQTK01000181">
        <property type="protein sequence ID" value="RUS85110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TU66"/>
    <dbReference type="STRING" id="188477.A0A433TU66"/>
    <dbReference type="OrthoDB" id="391817at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF4">
        <property type="entry name" value="DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06839">
        <property type="entry name" value="Zn_ribbon_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GRF-type" evidence="15">
        <location>
            <begin position="475"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="424"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="11">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="11">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA substrate" evidence="11">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RUS85110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="528" mass="59027" checksum="164609B024608F54" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TUA4</accession>
    <name>A0A433TUA4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase M12B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_007050</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000179">
        <property type="protein sequence ID" value="RUS85146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TUA4"/>
    <dbReference type="OrthoDB" id="6251728at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF159">
        <property type="entry name" value="ADAM METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12B" evidence="10">
        <location>
            <begin position="306"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="470"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS85146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="693" mass="75784" checksum="C927DE40FE64EDE4" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TUA5</accession>
    <name>A0A433TUA5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">EGW08_007105</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">EC2010</strain>
            <tissue evidence="19">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="RQTK01000180">
        <property type="protein sequence ID" value="RUS85141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TUA5"/>
    <dbReference type="STRING" id="188477.A0A433TUA5"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000243">
        <property type="entry name" value="serine/threonine-protein kinase Nek8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051997">
        <property type="entry name" value="STK_NEK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44535">
        <property type="entry name" value="PROTEIN CBG16200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44535:SF4">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="4"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="15">
        <location>
            <begin position="309"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="15">
        <location>
            <begin position="366"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="15">
        <location>
            <begin position="418"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="15">
        <location>
            <begin position="538"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="15">
        <location>
            <begin position="591"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RUS85141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="645" mass="69448" checksum="42ACC275FDC9B8DB" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TV42</accession>
    <name>A0A433TV42_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_006853</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000172">
        <property type="protein sequence ID" value="RUS85368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TV42"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS85368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="121" mass="14187" checksum="E07E9B1C16D0B454" modified="2019-05-08" version="1">MGDHPFPFAHLMIMSYYAFFTSSKKRLLAFSMKEMLKRRGFTQPTHGMTEKSIFGFQTCKFFLYVTNILIMQWKETSYSYTCNCSRKSVHQHLLSIVLCQYTATPSPPLKKKKNQPNKNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TW30</accession>
    <name>A0A433TW30_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">B9 domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_006456</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the B9D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000160">
        <property type="protein sequence ID" value="RUS85742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TW30"/>
    <dbReference type="STRING" id="188477.A0A433TW30"/>
    <dbReference type="OrthoDB" id="431939at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036038">
        <property type="term" value="C:MKS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010796">
        <property type="entry name" value="C2_B9-type_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12968">
        <property type="entry name" value="B9 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12968:SF1">
        <property type="entry name" value="B9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07162">
        <property type="entry name" value="B9-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51381">
        <property type="entry name" value="C2_B9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS85742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="206" mass="23036" checksum="E2E63E072664AE33" modified="2019-05-08" version="1">MANPSVFLLMVSGQIESAEFPEFDDIYCKYCFSYGLDWAITSGLDESITQITKKSRDEHQRFVWNFPIDATFKSTSPSGWPQLVVYAYGLDAFGTDVVRGYGVCHIPITPGRHRLRLPMFVPESSSLLQKLTAWFLGRRPEYVNPRVVAQGEGREVTRVRTQGFLTVSFNIIMKDMKKLGYDILPSDLQNPTIPAGVAGTDAAKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TWM9</accession>
    <name>A0A433TWM9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UNC93-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_006216</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-93 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000153">
        <property type="protein sequence ID" value="RUS86004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TWM9"/>
    <dbReference type="STRING" id="188477.A0A433TWM9"/>
    <dbReference type="OrthoDB" id="78663at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051951">
        <property type="entry name" value="UNC-93_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444:SF13">
        <property type="entry name" value="PROTEIN UNC-93 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444">
        <property type="entry name" value="UNC-93 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS86004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="47923" checksum="3ECA40D18CC1CBD0" modified="2019-05-08" version="1" fragment="single">KNLIVLCLGFIFVYSSFRAIQNLQSSVNGGQDLGVITMTVVHISMVFSSLLAPIIINVFTAKWAMCGGVMCFLAWFSAHVHPTFWTLVPTSVLVGLGQAVIWNAESSYVLKLAFDSAAASGNRDNLDHEMFRFHGIFLACFQSTHIWGNLISSLLLSWYKGQLLQAKDSPEPMGIPIGSDVVGGGQGDNANAYPAVGNGSYPDMDMYSQVDTDYGAIQILVYCGTLHRCTPGQDQLLPDIIVQHVRQLLHHKTLRLLTPLLLFNGMQQGFIFSDYNRYFVTCALGVNYVGYCMITLGASNVLGTIFVAFFSHRIPREVVLGFGGILHISLMIGFLIWIPGNSPVLYFVLAAAWGLCDAVWQTQCNTLICLTCADAPEVAFNNYRLVQSLGLALTFGSEPMMCLPARMYLLLTLLVVAIMFYVLAEYRIRNGDGDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TX65</accession>
    <name>A0A433TX65_ELYCH</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_006077</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
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        <lineage>
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            <taxon>Lophotrochozoa</taxon>
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            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="RUS86183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TX65"/>
    <dbReference type="OrthoDB" id="6162500at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS86183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="529" mass="57951" checksum="53E60B8B2A2E6911" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TYR8</accession>
    <name>A0A433TYR8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_005597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Gastropoda</taxon>
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            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000132">
        <property type="protein sequence ID" value="RUS86648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TYR8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS86648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="135" mass="15269" checksum="2513C653E12EAF7D" modified="2019-05-08" version="1">MRGKKSTPTAMVPVHWTSAYIVQVTAMYSTQNSRRNRWRFSGISDTNAAHKGGRALVCAVYSPTVHIAALCGSRAFLYTSPTCVTARPRFRHANRITCAAYFHFNSRSINGKGWWVGGKRKPTRSRLYYMYGIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U0F0</accession>
    <name>A0A433U0F0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_004933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000114">
        <property type="protein sequence ID" value="RUS87321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U0F0"/>
    <dbReference type="OrthoDB" id="6161056at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16148:SF11">
        <property type="entry name" value="CDKN2A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16148">
        <property type="entry name" value="NF-KAPPA-B-REPRESSING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="995"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
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        </location>
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    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="851"/>
            <end position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS87321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1032" mass="106582" checksum="7B69F90ADA95759F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U236</accession>
    <name>A0A433U236_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_004355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000098">
        <property type="protein sequence ID" value="RUS87877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U236"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS87877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="112" mass="12852" checksum="1975537B8513FCDD" modified="2019-05-08" version="1">MGYFVLSWMDYFVLPLIVPVTVFDELPCAVLDWLLYVVLDRLLCTVRNVLLCTVLDGLLCAALDVLAFIGYLSLSLMSYFVLFLMVYFKLPLIGFFVLSLVGYFVMYFVLDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U2J5</accession>
    <name>A0A433U2J5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_004207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
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            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000094">
        <property type="protein sequence ID" value="RUS88041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U2J5"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS88041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="305" mass="33212" checksum="CC16F463E7866A1B" modified="2019-05-08" version="1">MDNPQREEDENEARRLREVLRGRINQEQARRLLDEFGDPEPALDFVLNGSVQSPGVSALALCDNTYKNCQSKLRSLEIAFGPMLDAQWYSKYLKCKTLLVTLLGTGGEGRLLVPKSASLSSNHDVPGIMVGDEDDRCRPKIKGQVSIFSGKCLGPREDMTGIMVSDEDDRYGPKIKEQAERIVSGDPEKLFMGGWRGVVQPQICFMFWDGGSGEFARVLAQAGPSGNIWMLAGGRSCEFLYMLVQAGSSGLTRMQTGVRERGGQAGQKEEDGLKTLISRRRGSSLDSLLEGGVVSSSVVSGAVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U2K8</accession>
    <name>A0A433U2K8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_004266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000095">
        <property type="protein sequence ID" value="RUS87988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U2K8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS87988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="282" mass="31075" checksum="5A0624E9FCB833D0" modified="2019-05-08" version="1">MVQFSPAEESDCQTPGLTSKPNLNKSDSREAIQKTNQSGSLVRFSRRQRLPEYQGPLSANANIQAKPKQIRFKGGYSENKPKWFSGEILQTSAAARVPRATERPCHLILLLAVLSTNAVCLCAASRSPSRFRRACLGGTQPAFISSAGDQVGATEALHCPRSRLLGLKERRVWRWDVRAKYWDPDCGRRSRSVAWDPSPAQGRRSTVPGAAGHCRVAMPGVARHPDQPVSATQRPLGGRQPNSGVCMADSKSTLGYLWRPPETLYLRQSDSDFFLLSQVDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U2M3</accession>
    <name>A0A433U2M3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ZZ-type zinc finger-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_004221</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000094">
        <property type="protein sequence ID" value="RUS88055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U2M3"/>
    <dbReference type="STRING" id="188477.A0A433U2M3"/>
    <dbReference type="OrthoDB" id="20473at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070461">
        <property type="term" value="C:SAGA-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037830">
        <property type="entry name" value="ZZZ3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22705">
        <property type="entry name" value="ZINC FINGER, ZZ DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22705:SF0">
        <property type="entry name" value="ZZ-TYPE ZINC FINGER-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="171"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="9">
        <location>
            <begin position="179"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="8">
        <location>
            <begin position="357"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="293"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="297"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS88055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="49899" checksum="4B44B8C4F876402C" modified="2019-05-08" version="1">MDDGGYSYEEISEPYYFETDHVALKENSDYRQLLHTIALLEAQRQQATKDIDVLHKAQNDALENPLLFVENLQKGVDLALPKPQKIAELPDIQWEKYSLGSNLSSFASSSQHMTRNKKTSNEGAEKSIGNLKSKLMHGLITEANSSTNSVGSTASETDLVVVRGRAKDKSKPATFNQLWTAEEQQRLEHLLIQYPPEEVESRRWTKIADALGNRTPVQVASRVQKYFLRLAKEGLPIPGRMPNLSTYVRKGSHRHHRYNRIYQTSTFMQTHTPPVWMRDEDDDQGFCLYTSGDRTLGNGSEDNTPAMSETASTKDDSSDEDNLPEELINTPEYQELTRLKRVKKRLLAQQKSSITKHIGYKCDKCGCEPITGTRWHCIDCPADLSFDFCEDCSGLSFQKDKHDSSHRLHPFMNAVLDSDYVSNTAMDYNYLDPNYMPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U498</accession>
    <name>A0A433U498_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vezatin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_003611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000077">
        <property type="protein sequence ID" value="RUS88652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U498"/>
    <dbReference type="STRING" id="188477.A0A433U498"/>
    <dbReference type="OrthoDB" id="21151at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="765"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="933"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="530"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="830"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="947"/>
            <end position="973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS88652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1214" mass="134143" checksum="9726757DF9DB4177" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UC65</accession>
    <name>A0A433UC65_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SAYSvFN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_000826</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000012">
        <property type="protein sequence ID" value="RUS91396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UC65"/>
    <dbReference type="STRING" id="188477.A0A433UC65"/>
    <dbReference type="OrthoDB" id="71310at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039159">
        <property type="entry name" value="SAYSD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019387">
        <property type="entry name" value="SAYSvFN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13527">
        <property type="entry name" value="SAYSVFN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13527:SF0">
        <property type="entry name" value="SAYSVFN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10260">
        <property type="entry name" value="SAYSvFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="SAYSvFN" evidence="3">
        <location>
            <begin position="103"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS91396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="178" mass="20529" checksum="65555F625ABBFC71" modified="2019-05-08" version="1">MDAKLAAYRAKKEKQRQSENSFYNRFKSWLFGNDKLKQNGSKRALDERSQKRNIENQTAKQQNETSVQSNTSNDTDFFDDTTDVAEPTKLEIVTKWILRCCKLALWFCLWGLFIELQFGAVFFTVSAIIFTYINTRTGPRDGKLSAYSVFNKDCERIQGTVTAEQMQKSMFGVPGLKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UDH1</accession>
    <name>A0A433UDH1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LRRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_000213</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000003">
        <property type="protein sequence ID" value="RUS92000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UDH1"/>
    <dbReference type="STRING" id="188477.A0A433UDH1"/>
    <dbReference type="OrthoDB" id="1055097at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001360">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF210">
        <property type="entry name" value="CHAOPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="LRRCT" evidence="6">
        <location>
            <begin position="442"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="558"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="614"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="614"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="639"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS92000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="661" mass="73004" checksum="C62151F2FEBC1AA8" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UDX3</accession>
    <name>A0A433UDX3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_000192</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000003">
        <property type="protein sequence ID" value="RUS91979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UDX3"/>
    <dbReference type="STRING" id="188477.A0A433UDX3"/>
    <dbReference type="OrthoDB" id="193787at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016422">
        <property type="term" value="F:mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099122">
        <property type="term" value="F:RNA polymerase II C-terminal domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000036">
        <property type="entry name" value="Phosphorylated CTD-interacting factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039881">
        <property type="entry name" value="PCIF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022035">
        <property type="entry name" value="PCIF1_WW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21727:SF0">
        <property type="entry name" value="MRNA (2'-O-METHYLADENOSINE-N(6)-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21727">
        <property type="entry name" value="PHOSPHORYLATED CTD INTERACTING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12237">
        <property type="entry name" value="PCIF1_WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="85"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS91979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="695" mass="78889" checksum="7BEF2739A198F938" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z5G7</accession>
    <name>A0A3S0Z5G7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras-related protein Rab-4B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_022461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001579">
        <property type="protein sequence ID" value="RUS69775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z5G7"/>
    <dbReference type="STRING" id="188477.A0A3S0Z5G7"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS69775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="23934" checksum="42F1FC6A208D49B6" modified="2019-04-10" version="1">MSDSYEFLFKFLVIGSAGAGKSCILHQFIESKFKQDSNHTIGVEFGSKVVNVGGKAVKLQIWDTAGQERSLSLSLSLSLSLSLSLSLSLSLSLSLSLWETYNALTNWLTDARTLASPNIVIVLVGNKKDLEAEREVTFMEASRFAQENLMFLETSALTGENVEETFLKCARSILTKIESGELDPERMGSGIQYGDALRRMHRQEKLQPQASKPDCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z5Q3</accession>
    <name>A0A3S0Z5Q3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_020982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001245">
        <property type="protein sequence ID" value="RUS71259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z5Q3"/>
    <dbReference type="OrthoDB" id="6159060at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS71259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="326" mass="33139" checksum="6E0C7D71E17E4681" modified="2019-04-10" version="1">MESMERVSCATRGVGGLGGGLGGGLGGSGAGSTMGSFSPPGSCGGGGGSSAGSYAMSRFLPRAPPFADCMQGAAMAAMHHHHHGASMPHHSQHPGATPGGHHLSYSPYAAADWSMLYHHHHPHSFNNGLDRLTSGNGLDRLTSNGFDRAFSSNGLERLTAAASSNGYDRPSHPSHHHSHHHHRSPASHFFSMSPTNIITGSSGGASSKDFHGGSSLEQNSPSAVSASISSPHSLSSAAMASSSLGNGGGCPTGLGGISQLSPHHPAYPSPPLISRGPQYDPSSGVYHQHGLCGSGTLSPPPGGISCMSPDIDKKENKPKGENTKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z5V9</accession>
    <name>A0A3S0Z5V9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_022225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001513">
        <property type="protein sequence ID" value="RUS70008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z5V9"/>
    <dbReference type="STRING" id="188477.A0A3S0Z5V9"/>
    <dbReference type="OrthoDB" id="1922282at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052573">
        <property type="entry name" value="DnaJ_C_subfamily_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018961">
        <property type="entry name" value="DnaJ_homolog_subfam-C_membr-28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39158:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39158">
        <property type="entry name" value="OS08G0560600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09350">
        <property type="entry name" value="DJC28_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="51"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS70008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="390" mass="45819" checksum="3406C3317D937CB5" modified="2019-04-10" version="1">MAMLHRLSQIECRTGFSLANSLKYYMPEVYCFCRQHYQSGEVSSRKNSIDVCYSLLEIDPECSEEELRLAYLEKAKEFHPDRKTSTSNANKFSIIQEAYKTALDHKRGQELISNLEEEEEKRQQHFHDIKHTVPQHRRYLTFDGVGFGAPSKRERQYKQVRVAKATEAVYEHRLIQHGHDETSLVNVDKAQARKIKISNLIDRVVDDLIRESMQRGDFDNLSGKGKPLDHSDYNPFIDLTTHNINKIMVNNGFKPEWIMLSKEIRDNIALAREKLAVIREKLGPPPYSEQNQIRWEFHTSEFSHRVQEINVMINKYNFIVPFMEKQMVHYNVERNLNKVLAQHQEYLPKDSDGKPILADQLCPLPQVHSQNDKISWGEVWFNIKSLFKMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z6T1</accession>
    <name>A0A3S0Z6T1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_020302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001139">
        <property type="protein sequence ID" value="RUS71927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z6T1"/>
    <dbReference type="OrthoDB" id="10603405at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS71927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="337" mass="36585" checksum="E9E028C7C2A3298F" modified="2019-04-10" version="1">MKLTDSSLAWHLMEAHEHTECITCRSSVEDENEKSQDFGVLQDSLVSCVQNFFEFENYINLVGCLSLDFGGDRKLNVKFRRQVQREPECEAQGPQEPLLRQTCSPLQPLSSELTTQNSPALELKSSPEALAEATTPHKVSAACPAAYTAEGESPIATAVECRSFNLSSCSVESGLSVEIDVVGTDSSQEIIPEEGHDDGTIEMHAEAAEEPISKEQATEKTHYMSSPMSTHNPELKFCDNSSLISKPEEVSLYQPEGVAPGDASDIDTSEQISESQIEASSFGSGCHPVPTKESCSAEQLDQRKDVHSSGPAVQLADRPLDMSLFKSDGNGRATPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z7E7</accession>
    <name>A0A3S0Z7E7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">galactosylceramidase</fullName>
            <ecNumber evidence="2">3.2.1.46</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Galactosylceramidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EGW08_019845</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">EC2010</strain>
            <tissue evidence="17">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 59 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.46" evidence="2"/>
    <dbReference type="EMBL" id="RQTK01001073">
        <property type="protein sequence ID" value="RUS72385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z7E7"/>
    <dbReference type="STRING" id="188477.A0A3S0Z7E7"/>
    <dbReference type="OrthoDB" id="440760at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004336">
        <property type="term" value="F:galactosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006683">
        <property type="term" value="P:galactosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000026">
        <property type="entry name" value="galactocerebrosidase precursor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049162">
        <property type="entry name" value="GH59_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049161">
        <property type="entry name" value="GH59_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001286">
        <property type="entry name" value="Glyco_hydro_59"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035394">
        <property type="entry name" value="Glyco_hydro_59_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15172">
        <property type="entry name" value="GALACTOCEREBROSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15172:SF1">
        <property type="entry name" value="GALACTOCEREBROSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02057">
        <property type="entry name" value="Glyco_hydro_59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21708">
        <property type="entry name" value="Glyco_hydro_59_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17387">
        <property type="entry name" value="Glyco_hydro_59M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00850">
        <property type="entry name" value="GLHYDRLASE59"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0746">Sphingolipid metabolism</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018631343" description="galactosylceramidase" evidence="13">
        <location>
            <begin position="19"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 59 catalytic" evidence="14">
        <location>
            <begin position="65"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 59 central" evidence="15">
        <location>
            <begin position="371"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 59 C-terminal lectin" evidence="16">
        <location>
            <begin position="521"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="12">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601286-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF21708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RUS72385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="698" mass="77680" checksum="BE142A61E258FFDF" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z8N9</accession>
    <name>A0A3S0Z8N9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_018966</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000956">
        <property type="protein sequence ID" value="RUS73271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z8N9"/>
    <dbReference type="OrthoDB" id="161814at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF115">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS73271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="206" mass="23019" checksum="C709EB6436CCE738" modified="2019-04-10" version="1">MTAADAMMQDFPFPQCPAMTVPDAMIDPAPQHWTASLKLPKFLIIICSAGDLLLAKMYFHFGPEKHLLFHNWHAETPGAMIGACCAIFCLAVLYEGLKELRSQLQRSYTLPTSGLFDTLGRPQAELRDLLFEEGDRKAVWTIYSWRHLVQTLLHMVQAILSYSLMMVFMTFNLGLCLALVLGLGVGYFLFGWTRDAPGAVGTQPCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZBE0</accession>
    <name>A0A3S0ZBE0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">60S ribosomal export protein NMD3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_017224</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NMD3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000778">
        <property type="protein sequence ID" value="RUS75001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZBE0"/>
    <dbReference type="STRING" id="188477.A0A3S0ZBE0"/>
    <dbReference type="OrthoDB" id="203821at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048899">
        <property type="entry name" value="NMD_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048898">
        <property type="entry name" value="OB_NMD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746:SF2">
        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21193">
        <property type="entry name" value="NMD_SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21192">
        <property type="entry name" value="OB_NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nmd3 N-terminal" evidence="9">
        <location>
            <begin position="22"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 SH3" evidence="11">
        <location>
            <begin position="253"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 OB-fold" evidence="10">
        <location>
            <begin position="317"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS75001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="508" mass="58522" checksum="473BA27557BB207B" modified="2019-04-10" version="1">MEYLDSGGPSNARQQHYSLICCCRCGLQIEPNPTNMCVNCLRSDVDITDGIPKTSALSFCRGCERYLQPPNQWVKATLESRELLSVCLKKLKGLSKVKLVDAGFVWTEPHSMRIKVKLTVQKEVMNGAVLEQMFVVEFVVQAHMCDDCHRVEAKDFWRAAVQVRQKSDHKKTFFYLEQLILKHRAHRSTVNIKPMADGLDFFFTKQDDAKKLVEFLSAYVPCRYVTGRELISHDIRSNKFNYKYTFSVEIVPICKDHIVCLPQKTAQQMGSISPLCIVTRVTQTIHVIDPCTLQWAEMSGTQYWRQPFPALVSPKHLIEYMVMEIELVPEKDRPLRPRMSTKHGLADVYVARMSDLGINDQQFHCRTHLGYLLKTGDTVLGFDFTNANLNHAHFDKLNTDKVPDVMLVKKVFDRSKRLRRRKWRLERFDGADELDTESVTRDYNDFLDDLEEDQAYRENVNIYKDPTKVQVEDDTDDEGAPQISLQEMLEDLRISEDATGGEGAAMME</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZCZ2</accession>
    <name>A0A3S0ZCZ2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_017332</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tumor necrosis factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000788">
        <property type="protein sequence ID" value="RUS74901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZCZ2"/>
    <dbReference type="OrthoDB" id="6093752at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005164">
        <property type="term" value="F:tumor necrosis factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006052">
        <property type="entry name" value="TNF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11471:SF13">
        <property type="entry name" value="TNF FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11471">
        <property type="entry name" value="TUMOR NECROSIS FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00229">
        <property type="entry name" value="TNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50049">
        <property type="entry name" value="THD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="THD" evidence="7">
        <location>
            <begin position="318"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="38"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="92"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="194"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS74901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="467" mass="49954" checksum="5B7E985AEF96E527" modified="2019-04-10" version="1">MRGLIHTDLMSPPEFKLSESITEPSSITSMAKDTRVTFDSATNNNNGTTTGALSPNGMGGGGGGPGGLGFGMGHHHTGLAPHQQAPAHLLQHQNHQNHQHHHSAPHKSKLGRGHSRIAERQVSTEDAENCINEISESFPALSNKAHRLMRQVSGSFNSRTLKVALIFSIMLNIVMGISFGVFFGMWMSWDRNGSGDGGTGSGSGDSSGISGHHRPTSQAFTGHHGGYHLGGQEVLAHGKSVNPAVMAALGSKIAANQNTIEAICAYCPARPCANQPPSGSGFGHGGAASQASELGRGQEPPKCVCVNEAFQSTLKTLSAAHMMLDVYETKKQKSLIWLTHDADNICYVGEGVRYERGELTILHTGQYHVYSQVTFSTIDNPMPSGMSELLLLFSIQRRPRQSGGSPRSEPVQTILLSKLTMEPGQEENDMVSGIVKLTEGDVLSVYISHPSLLKNTLPANYFGVFKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZJT0</accession>
    <name>A0A3S0ZJT0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_015820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000664">
        <property type="protein sequence ID" value="RUS76410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZJT0"/>
    <dbReference type="OrthoDB" id="6132286at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018604232" evidence="1">
        <location>
            <begin position="27"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS76410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="222" mass="25766" checksum="9DC6B343C6A33A1B" modified="2019-04-10" version="1">MRSSSNEMATHTFEFVLLFLSIVVLAPREVPISKFYGDGGARDTRRFVEEVKAAWSAQRCETDQEKRGILWSHLGEEVRQELNCLLDGDTRDPRWMLVTIANNYGERRSVSCLLGAFHATRQRQGEGIRAFSHRLRDVFDALLGRQRDTGVEVRFWIVACVLLRDHSADILLDPILHRQPRERITNNADVSFLELREQAIRWEEDQESDRSREVVASHQVYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZLV6</accession>
    <name>A0A3S0ZLV6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_021827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001416">
        <property type="protein sequence ID" value="RUS70410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZLV6"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS70410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="124" mass="13268" checksum="D568F28347BEFF4E" modified="2019-04-10" version="1" fragment="single">MQNVRYSGSESVTIETDSVNSRNDYTNGNCSQQQNIAGNGFVNKGFRDSNQLASRISTQKRNGNKSPLATVSKGSNFSDKRSLVTPANRSEEESVSNFYGNVGDLAGGAGENVLLAPGKRPVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZMR8</accession>
    <name>A0A3S0ZMR8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Globin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Myoglobin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_021185</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="9">Belongs to the globin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001280">
        <property type="protein sequence ID" value="RUS71051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZMR8"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005833">
        <property type="term" value="C:hemoglobin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002336">
        <property type="entry name" value="Erythrocruorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47217">
        <property type="entry name" value="GLOBIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47217:SF1">
        <property type="entry name" value="GLOBIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00611">
        <property type="entry name" value="ERYTHCRUORIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="4 9" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="10">
        <location>
            <begin position="27"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS71051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="187" mass="20656" checksum="7FE8AA7998128535" modified="2019-04-10" version="1">MGGVFSYLLSWVTPGPTYDLTPDPTTGLSERDCHAILDTWALVSDRKAIKQNGVNFFLVLFKEHPYMLKYFPAFKGLSEDELGDSPLLKAHATSVMYAIKSYVGTIDDAETLAGLVTKMANSHVPRGIKTKDLENLAVVFLDFMGSALGSQWTPEAANAWKQLFDVHCQLYDKVYTELKAGDLANGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZPH6</accession>
    <name>A0A3S0ZPH6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_020048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001099">
        <property type="protein sequence ID" value="RUS72199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZPH6"/>
    <dbReference type="OrthoDB" id="6077968at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS72199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="470" mass="51135" checksum="658CB9D044A3FDAA" modified="2019-04-10" version="1">MSSMNNHNNNNNTNFHRAMSALVLSKGVSLLGSWHEDVFTEDLLQKIAAYAAAEKGKKAKVKLSGAGLRISRPRFLQADSSQFFAFDAIKTVTRNPHAPRCVMFILADQRCRYQIIAVRCQSDVDASDLINFSAQMKKEQKVSNVEFKKRDNGNWTLRERSAHNANRHMAELFNEQTNGGGGDGVIAISPASPAVITTQRSRDGSVSNHVPVLDASRPSVRGSYVKRQHSSSTKRASRSSADIDGEYIVETVVDTGDRTDGVDEMRALVEQQQNISAGTSNGKPVMAQPGVVSVYSHGVNTHTTHEALPSRPQVLTAVPAAQQQKPQPAVVHRAAPVAYEARIIGGTTTGYFPGPNPWGSHRRVSGVPGSSTLPHQNRSRTDSLQGNFDRVSMLSVSKGSSRSRSMRSIPTTIERSIEDTYARPVILRRYGSAQLVAGRPRPASYHVVGTGTNELQIYNGRGLGQGDVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZPN2</accession>
    <name>A0A3S0ZPN2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_009425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000270">
        <property type="protein sequence ID" value="RUS82805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZPN2"/>
    <dbReference type="STRING" id="188477.A0A3S0ZPN2"/>
    <dbReference type="OrthoDB" id="5985714at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01450">
        <property type="entry name" value="vWFA_subfamily_ECM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF84">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="130"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS82805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="310" mass="33439" checksum="FE13F2947928E0FE" modified="2019-04-10" version="1" fragment="single">MFSVSAGGRTQAADILIVMTDGRSQDTQRTLQSAQALKQQGVWIIAIGIADATDEELYGMASSPSDVFKSPNFDTLQNILDKVNARMCQVTKQQPACKTSTYGCCPDGTAFAQGPNGEGCTADQCAAQADIILVMDSSASIQPTEYAKELDFAAKIIDDFKIGPNDVRFAAIVFGSSPTKLFNLADHNSPQTLQEAIKRAPFLNSGTKTNKALEMITQDQMFSSRWGGRDFAKDIVIIITDGRSTYASWTQLAANRLKASNVTIISVGIGADVDQRELRGLASKPDDVLLASNFDSLKDIQDDVGKRTCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZRU5</accession>
    <name>A0A3S0ZRU5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PKD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_011034</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS10-related sortilin family. SORCS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000350">
        <property type="protein sequence ID" value="RUS81204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZRU5"/>
    <dbReference type="STRING" id="188477.A0A3S0ZRU5"/>
    <dbReference type="OrthoDB" id="443634at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00146">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031777">
        <property type="entry name" value="Sortilin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006581">
        <property type="entry name" value="VPS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050310">
        <property type="entry name" value="VPS10-sortilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106">
        <property type="entry name" value="SORTILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106:SF47">
        <property type="entry name" value="VPS10 DOMAIN-CONTAINING RECEPTOR SORCS3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00801">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15901">
        <property type="entry name" value="Sortilin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00602">
        <property type="entry name" value="VPS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="PKD domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1043"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="7">
        <location>
            <begin position="731"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="7">
        <location>
            <begin position="853"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS81204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1136" mass="127358" checksum="09C1CB504D75B13B" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZS13</accession>
    <name>A0A3S0ZS13_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_010907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000343">
        <property type="protein sequence ID" value="RUS81340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZS13"/>
    <dbReference type="OrthoDB" id="6083774at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026913">
        <property type="entry name" value="METTL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32026">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32026:SF10">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13383">
        <property type="entry name" value="Methyltransf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS81340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="172" mass="20301" checksum="60D322058AD75F36" modified="2019-04-10" version="1">MFKHGCEVHSFDPSMLQPSYQRNESSWFHNLGLSSRNTDSYRPPPDQYVKAPQVWQMRTLTSVKEMLGHTGRVIDLLKIDIEGFEWDVVENMRETGELELLRQFSLEFHLFPKFPPMEDYVHLYKTFTNLREEMGFAEFSAHPHPKTLEKDKFNLQGDSQFVNTLFRYPPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZSS9</accession>
    <name>A0A3S0ZSS9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_006334</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000156">
        <property type="protein sequence ID" value="RUS85931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZSS9"/>
    <dbReference type="STRING" id="188477.A0A3S0ZSS9"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16267">
        <property type="entry name" value="HBS1-like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04093">
        <property type="entry name" value="HBS1_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000035">
        <property type="entry name" value="HBS1-like translational GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000020">
        <property type="entry name" value="Translation elongation factor EF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000204">
        <property type="entry name" value="Translation elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015033">
        <property type="entry name" value="HBS1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037189">
        <property type="entry name" value="HBS1-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08938">
        <property type="entry name" value="HBS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109732">
        <property type="entry name" value="HBS1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Tr-type G" evidence="12">
        <location>
            <begin position="349"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="139"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="252"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS85931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="786" mass="85697" checksum="BBB64EC5B647A06A" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZUU7</accession>
    <name>A0A3S0ZUU7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable cytosolic iron-sulfur protein assembly protein CIAO1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_004949</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.</text>
    </comment>
    <comment type="function">
        <text evidence="3">Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As a CIA complex component, interacts specifically with CIAO2A or CIAO2B and MMS19 to assist different branches of iron-sulfur protein assembly, depending of its interactors. The complex CIAO1:CIAO2B:MMS19 binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. CIAO1:CIAO2A specifically matures ACO1 and stabilizes IREB2. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat CIA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000115">
        <property type="protein sequence ID" value="RUS87269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZUU7"/>
    <dbReference type="STRING" id="188477.A0A3S0ZUU7"/>
    <dbReference type="OrthoDB" id="284782at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000136">
        <property type="entry name" value="Probable cytosolic iron-sulfur protein assembly protein CIAO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03037">
        <property type="entry name" value="ciao1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028608">
        <property type="entry name" value="CIAO1/Cia1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR PROTEIN ASSEMBLY PROTEIN CIAO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920">
        <property type="entry name" value="WD40 PROTEIN CIAO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="11"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="56"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="100"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="145"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="189"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="299"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00060126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS87269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="336" mass="37020" checksum="58C0D849A8079176" modified="2019-04-10" version="1">MQGSLKEIQQLTGHTDQVWCVAWSPSGSLLASCGGDKTIRIWGKEGDSWVCKSVLMDAHTRTIRTVSWSPCGQYLAAASFDATTSIWSRKSGEFECLATLEGHENEVKCVGWACTGNLLATCARDKSVWIWEVTADEEFECASVLSTHTQDVKCVKWHPTSELLASCSYDDTIRLYREASDDWESCAMLKGHKSTVWSLDFDKDGHRLASAGADASLKIWQEYEPGNPEAIATPDNIPVWKCVCTIAGHHERPIYSVSWCSLSGNIATASGDDSLCVYKETSSEDSKNAPKFEIAVRQKGAHSEDVNCVCWNPVQEGMLASCSDDGSVKIWQLLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZV60</accession>
    <name>A0A3S0ZV60_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_008566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000235">
        <property type="protein sequence ID" value="RUS83660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZV60"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018536111" evidence="1">
        <location>
            <begin position="44"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS83660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="121" mass="12670" checksum="0C0DED77EECC8651" modified="2019-04-10" version="1" fragment="single">MSLTDAASLALSFAIPVRRPTMPLTMPLSLMIGLCLLLPNCASQATVAIPKEGVQSADSLISEFGSSSSSSSSGLTDVQLRSLVVKATGHSLEYVSQIIGPCDDQYTDSEGNKLNCTFDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZVG1</accession>
    <name>A0A3S0ZVG1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-disulfide reductase</fullName>
            <ecNumber evidence="1">1.8.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_004556</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-dithiol + NAD(+) = [protein]-disulfide + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10593"/>
            <dbReference type="Rhea" id="RHEA-COMP:10594"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.8.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[protein]-dithiol + NADP(+) = [protein]-disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18753"/>
            <dbReference type="Rhea" id="RHEA-COMP:10593"/>
            <dbReference type="Rhea" id="RHEA-COMP:10594"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.8" evidence="1"/>
    <dbReference type="EMBL" id="RQTK01000103">
        <property type="protein sequence ID" value="RUS87715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZVG1"/>
    <dbReference type="OrthoDB" id="409136at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047134">
        <property type="term" value="F:protein-disulfide reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052259">
        <property type="entry name" value="Nucleoredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13871">
        <property type="entry name" value="THIOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13871:SF96">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="550"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin-like fold" evidence="8">
        <location>
            <begin position="33"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS87715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="587" mass="65944" checksum="EAC7AFBBE9114873" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZXS9</accession>
    <name>A0A3S0ZXS9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_003590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="RQTK01000077">
        <property type="protein sequence ID" value="RUS88631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZXS9"/>
    <dbReference type="STRING" id="188477.A0A3S0ZXS9"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF13">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="28"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS88631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="284" mass="32503" checksum="12F089B6369C5BC0" modified="2019-04-10" version="1">MALFQPTKFENPYTIHKFEDDFYEKYNLKKVQFLGEGMAGKVYLVKPKSGRGRWQAVKEFSHYPTEVRERNMRHFAMETTVMQVVSHPHLVPCHLAASGHDYSAIAMPYYPQGDLVLSGRQEPNRVHRLMSKVARAVEHLHKWNIAHNDIKLENVFVDGSDDAHLGDMGFALRVKDPLGFSPAWRVGGTKDYWSPEKLAADPHYKIDPFKCDVYAVGIMYWVLVTGIMDFTAGTDFVAKLVKTQDLNISHLQRSVLETLLEPNPLARPTAFEMVHILSLNESFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZZK8</accession>
    <name>A0A3S0ZZK8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_013190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000475">
        <property type="protein sequence ID" value="RUS79033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZZK8"/>
    <dbReference type="STRING" id="188477.A0A3S0ZZK8"/>
    <dbReference type="OrthoDB" id="9893603at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019011">
        <property type="entry name" value="Cryptic/Cripto_CFC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09443">
        <property type="entry name" value="CFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018781562" description="EGF-like domain-containing protein" evidence="6">
        <location>
            <begin position="29"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="29"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS79033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="264" mass="29609" checksum="5381332DFE3B5D30" modified="2019-04-10" version="1">MLPAQKLWYCVSSLQWIVHLALLTQAHSSGTHPKGNHPDNSVPTSTAPPQLPSLLRARPQSPSDWTDRRVDNGGILDRPTTTCCYNGGLCVMGVFCHCSEKYYGFRCEHERVSCGPVQHDQWARLGCNLCRCFDARLHCLANVYSGCEGKPVDEDIRAEEYLDDMEIYPMDEEPSVDIDAYNTDDYYYYWDDGDQVDYVDKSGSGQNHRTSGRGKSRSKGGHSASSVQTWPPCLILLSLCGLVTVLTRSVQLVSQDRKEIFFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZZS5</accession>
    <name>A0A3S0ZZS5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ER lumen protein-retaining receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_002153</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ERD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000040">
        <property type="protein sequence ID" value="RUS90111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZZS5"/>
    <dbReference type="STRING" id="188477.A0A3S0ZZS5"/>
    <dbReference type="OrthoDB" id="7694678at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00951">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00952">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS90111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="281" mass="32273" checksum="2E600B54D9EE53CF" modified="2019-04-10" version="1" fragment="single">RRFATSARATLRNYGRVRPSDLDHQAVHEKKTQKNASFTFSLSSTGLFVSKTLTIVINIMNIFRLVGDMSHLLAIILLLLKMWKTRSCAGISGKSQILFALVFATRYLDLFTSFISVYNSTMKVFFISSSLFTVYLMYMKFRATYDMNHDTFRMEFLVVPVGGLAFLVNHEFSPLEILWTFSIYLESVAILPQLFMMSKTGEAETITSHYLFALGSYRGLYILNWIYRYYFEGFFDLIAVVAGCVQTILYCDFFYLYITKGINGELSLEGKETQLTGIRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A175</accession>
    <name>A0A3S1A175_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_012130</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000410">
        <property type="protein sequence ID" value="RUS80131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A175"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015375">
        <property type="term" value="F:glycine:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF240">
        <property type="entry name" value="BLOATED TUBULES, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="351"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="453"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="485"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="560"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="160"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS80131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="648" mass="71552" checksum="BBDBFE79C12B5526" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A419</accession>
    <name>A0A3S1A419_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_002130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000040">
        <property type="protein sequence ID" value="RUS90088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A419"/>
    <dbReference type="OrthoDB" id="10021290at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS90088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="109" mass="12682" checksum="D96EEAC99E854582" modified="2019-04-10" version="1">MTTIRSSVRPSQPKQPWGTILKPEFGMGYQKMTEYEIEQTVSRLNTIPPPKEQVYHRPNPKMTQEEIDAMLDRLTQNDKSKIPDSDRRVISSSYREMGVVSSYAWKGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A4C9</accession>
    <name>A0A3S1A4C9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_001973</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000036">
        <property type="protein sequence ID" value="RUS90284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A4C9"/>
    <dbReference type="STRING" id="188477.A0A3S1A4C9"/>
    <dbReference type="OrthoDB" id="1744869at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000001">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="10">
        <location>
            <begin position="18"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="10">
        <location>
            <begin position="95"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS90284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="157" mass="16069" checksum="9121A8680F0F7F62" modified="2019-04-10" version="1">MADYDMEAPPYAPFFGVMGVTAAMSFCALGAAYGTAKSGTGISAMAVMKPELIMKSVIPVVMAGIVAIYGLVVAVVITQDMPSKGYTLFKSFLHLGAGLSVGLSGMAAGFAIGIVGDAGVRGTAQQPRLFVGMILILIFAEVLGLYGLIVALILSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AFD1</accession>
    <name>A0A3S1AFD1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_001855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000034">
        <property type="protein sequence ID" value="RUS90360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AFD1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018605319" description="C2H2-type domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS90360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="18376" checksum="633DF6C55ADCACB1" modified="2019-04-10" version="1" fragment="single">SHPSCVFISFSFFTLSLFPYHGGRAPALLPACLPVLDGCGGLLHVPGPHPRLQDLLHQLHPQVRALWLGLSCPDRGCHPGCRLHGQLRLHKLGHVLAAEPGLLRGVRGSRGAHPAAQLCGLRPGGPPTVQHGQFQAQQDRQAQVGSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AUL8</accession>
    <name>A0A3S1AUL8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_019616</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001042">
        <property type="protein sequence ID" value="RUS72618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AUL8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS72618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="118" mass="13109" checksum="02AFD405049AB6AC" modified="2019-04-10" version="1" fragment="single">MPCGKQVILCLFRYEFKNNPERKKGLETAAAWQVSVSEQIYEPDRQLFQQWPEWAVCSKALIISPVSLTLARSDAANTGAFNHSHPASVPVLAAKWSGFVPPPSQIPPQSWASSECRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AVR9</accession>
    <name>A0A3S1AVR9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_018703</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000926">
        <property type="protein sequence ID" value="RUS73545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AVR9"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018637893" description="Secreted protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS73545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="24189" checksum="6D05B3F91723606A" modified="2019-04-10" version="1" fragment="single">MLQSCRFPLLCIGVAVVAVLTTAAPTEIPEETSPIADPREADGQPPSRPSLGGWSSLIGGLSRRRSSSDQESSRNGRRNNQPHSGGRRRGQQLVLASKDENPVDSDDVNAIDKTRRRGSDSKNRQEQETLFKTVATPQKRPEPEVSSTDQQAENDGEGGGRFGRGNGGRRGDKKNEDIEAEEVKSEGRRSKKNKDKSEAEQNESQPQGQQESNPDPSESQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AZB4</accession>
    <name>A0A3S1AZB4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">pyridoxal 5'-phosphate synthase</fullName>
            <ecNumber evidence="7">1.4.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_020125</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the pyridoxamine 5'-phosphate oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="7"/>
    <dbReference type="EMBL" id="RQTK01001112">
        <property type="protein sequence ID" value="RUS72112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AZB4"/>
    <dbReference type="STRING" id="188477.A0A3S1AZB4"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.110.10:FF:000005">
        <property type="entry name" value="NAD(P)H-hydrate epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01629">
        <property type="entry name" value="PdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019740">
        <property type="entry name" value="Pyridox_Oxase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00558">
        <property type="entry name" value="pdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004231">
        <property type="entry name" value="PRK05679.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851:SF0">
        <property type="entry name" value="PYRIDOXINE-5'-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PYRIDOXINE-5-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01064">
        <property type="entry name" value="PYRIDOX_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0288">FMN</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="12">
        <location>
            <begin position="99"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridoxine 5'-phosphate oxidase dimerisation C-terminal" evidence="13">
        <location>
            <begin position="234"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS72112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="288" mass="32816" checksum="2AE1474637A299EB" modified="2019-04-10" version="1">MAAQRFLSRLGLFPFRFHNTCNKLHLQLRTCSLAGFSSGAGASQGPHQSNRSYDFDSGAISEMRKAYKGTTEIFDVGDLVSKDPFKQFLAWFEEASQVDSIREANAMSLATSTKDGIPSVRMVLMKGIDETGIYFYTNFQSQKAKELEENPNCSIMFYWEALNRSVRVNGVAERISEEESTKYFHSRPKASQIGACVSLQSQVISSRKVLDDRNEELTKKYSSDDTPVPKPDYWGGFKVIPSRFEFWQGQTNRLHDRIVFRKLQPNEEINSETTAEGSNGWFYERLMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B064</accession>
    <name>A0A3S1B064_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_023616</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01002191">
        <property type="protein sequence ID" value="RUS68623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B064"/>
    <dbReference type="STRING" id="188477.A0A3S1B064"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003492">
        <property type="entry name" value="AGAP012735-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="206"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS68623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="242" mass="26856" checksum="F86ACB182687FEEC" modified="2019-04-10" version="1" fragment="single">RQAISIIPQDPVLFTGSVRRNLDPFDEYSDSQLWRALDEVQLKETIGNHPENLYMEVTEGGSNFSAGQRQLMCLARAVLGNARILMIDEATANVDPITDDLIQQTIRIKFKACTVLTIAHRLHTVIDSDRILVLDAGQIAEMDTPARLLSRGQGGLFYSMVEQMGSAELEHLTQLAARGHHPTSVETFEPVANGVTHTTAEPIQTTRSEMQPSNSEIEIRGTQSRDLQGIDNEAFDSEDTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B3P5</accession>
    <name>A0A3S1B3P5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_016917</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000752">
        <property type="protein sequence ID" value="RUS75328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B3P5"/>
    <dbReference type="STRING" id="188477.A0A3S1B3P5"/>
    <dbReference type="OrthoDB" id="5332336at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006970">
        <property type="entry name" value="PT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33683">
        <property type="entry name" value="1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33683:SF46">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04886">
        <property type="entry name" value="PT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018564019" evidence="4">
        <location>
            <begin position="26"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="241"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="254"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS75328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="399" mass="43949" checksum="E68CBDE5E16313F3" modified="2019-04-10" version="1" fragment="single">FRLPVWRRVPLTLFIVLLSVELALAARKVEIWEKDDSGSGDEDNESGKSRRAISSRIVSRLNLGANVDVQPEDSLLSAQGNTKKKYSETYKGYKVFNTGLDVEEDASGGVAIVAGDVYADIEGDLGTVDHCDLPQATAKKIALRKFGLKPKNINIVREAYDNYVYIDSDNVARWAVDVELSLFKKDKTFSRPVVFIDACSQEILDFFDRKGFFTIPPEVTGFDTDSPYDVSPNFPTDVFTDLFTDGPKFPTDDSSNNPTNFPTNSPTNAPTNSPTNAPTNSPTNSPTNAPTNSPTQGPTNQPPGKCDVRDTAGNPKRVVKFGPGEEFCLTPMRRSSDGSMCYLENQYVKTVDLKGREDDSSTKIASFRCSEGYDDEKNGGFSPVLDAFFFCTASSRLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B437</accession>
    <name>A0A3S1B437_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_016644</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000727">
        <property type="protein sequence ID" value="RUS75580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B437"/>
    <dbReference type="STRING" id="188477.A0A3S1B437"/>
    <dbReference type="OrthoDB" id="6085995at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF424">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="54"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS75580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="282" mass="30842" checksum="ACAD5C7F53A13480" modified="2019-04-10" version="1">MEEVLTTIGSQDVQKSTVGIADTTPGFGCQDEDLFLPGSLRYILIVFGLVLMIENISMIVTIARHRKLRTNSNILVASLAFSDVLIGLLCFEMGLISEPGGVRSNIRLSEFAQRTFDTLGSGTNCGLIAISMVHLAALSVDRYLFLLWPLHYHHRVTQRRVAMAAAAIWTLGCGYTLLPIGLYAHPQYHTRCIIHNTPVEYEGAPLTCILVSCITVVSVCTFGIAKLAFGHSRKREIRNNGAVATDNDIVDGNKKATYLSRGNNGAIYTVNNIPKLSKEMVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B5G1</accession>
    <name>A0A3S1B5G1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_019803</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001067">
        <property type="protein sequence ID" value="RUS72441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B5G1"/>
    <dbReference type="STRING" id="188477.A0A3S1B5G1"/>
    <dbReference type="OrthoDB" id="417450at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071818">
        <property type="term" value="C:BAT3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041421">
        <property type="entry name" value="Ubl4_C_TUGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047154">
        <property type="entry name" value="UBL4A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46555">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46555:SF1">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17840">
        <property type="entry name" value="Tugs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS72441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="153" mass="17152" checksum="328673958F8B2594" modified="2019-04-10" version="1">MHLTVKILNGKECTLAASSCSLVSDVKEQVEALLSIPVTDQKLIFKGKALLDGKLLKDYGVEDCAKITLVVKKSTSKQPAGASGEEGRARQNASKNVQQKAVWEKLRTFLLRHFREKDAEAVLLEFQKEFERNLSTLSLDDIERFAMTKLRQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B893</accession>
    <name>A0A3S1B893_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Histone deacetylase</fullName>
            <ecNumber evidence="2 10">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EGW08_013865</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">EC2010</strain>
            <tissue evidence="16">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2 10"/>
    <dbReference type="EMBL" id="RQTK01000514">
        <property type="protein sequence ID" value="RUS78372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B893"/>
    <dbReference type="STRING" id="188477.A0A3S1B893"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016581">
        <property type="term" value="C:NuRD complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000003">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="15">
        <location>
            <begin position="27"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="388"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="431"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="442"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="494"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="510"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RUS78372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="547" mass="61726" checksum="FE69F5BFBE2507E3" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B8V1</accession>
    <name>A0A3S1B8V1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_014382</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000546">
        <property type="protein sequence ID" value="RUS77869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B8V1"/>
    <dbReference type="OrthoDB" id="8641091at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018716636" description="CUB domain-containing protein" evidence="3">
        <location>
            <begin position="28"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="18"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS77869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="142" mass="15778" checksum="6C6BA5C596A2E83B" modified="2019-04-10" version="1">MTSRQSHAAAFLLLSLICTGIPRQAASFELITYGDSKDRTIGSDKYPDGYSAGANVTWSWSVSSGYWAVFFLDFDLDRGLDGYGDGDQLEISDGYRTPRYHSARNPPVVPYRSRGSRLRISFTTDSLTGDSAFRGFQLRVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BAW3</accession>
    <name>A0A3S1BAW3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_015939</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000674">
        <property type="protein sequence ID" value="RUS76293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BAW3"/>
    <dbReference type="STRING" id="188477.A0A3S1BAW3"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF9">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018650112" description="Beta-lactamase-related domain-containing protein" evidence="1">
        <location>
            <begin position="31"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="37"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS76293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="728" mass="83154" checksum="CAF3C7CBA776FBF0" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BD56</accession>
    <name>A0A3S1BD56_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_011012</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000349">
        <property type="protein sequence ID" value="RUS81218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BD56"/>
    <dbReference type="STRING" id="188477.A0A3S1BD56"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="37"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="274"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="314"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS81218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="445" mass="48187" checksum="3B6C0C1B1F056311" modified="2019-04-10" version="1">MNNRDGPKGVLTDNDRDIFVFTAVVLLLVVAIFGLFSNTVNILVFRKHGFKDSMSVTLFSLCISDILFLLFLIPTSAIQFPGFASLSRAAGSMYGYRQAIGQCVQVSRLVSVWTTVLVTLERCLCIVKPLSVKQIFTPRRSMAAILAVSCLLLLPTAMTVSLFYAEKGRRLPVVFLAGESNVSKFNITGAPKTPGPANVYQSIVFGLRAVCNLASFLAVLVSMVYLAAMLRKRSPNVRGSGNNRGLTPAPTTATGNNKRSAKVYPIGVLPSPQYLAPPRPASPKTCQQKAASSSRETHIETQRTPECTPAIDIPSTSHQASSPSAAVTETDCTESSDSARRLAQGGGSNAIAASADLRTRRLGRMVLVLSCVNLLCFLPAGVCLGIGLVEPQFRSQGRYGNIFQVVWICLVVLDALNASTNIFVYYRMSSNYRQTLDKMLGMNRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BFI5</accession>
    <name>A0A3S1BFI5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Prominin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_012655</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prominin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000442">
        <property type="protein sequence ID" value="RUS79584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BFI5"/>
    <dbReference type="OrthoDB" id="6229420at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008795">
        <property type="entry name" value="Prominin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22730">
        <property type="entry name" value="PROMININ PROM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22730:SF1">
        <property type="entry name" value="PROMININ-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05478">
        <property type="entry name" value="Prominin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018592662" description="Prominin-like protein" evidence="8">
        <location>
            <begin position="27"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="674"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS79584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="736" mass="81384" checksum="34C43332C8236EFB" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BGT7</accession>
    <name>A0A3S1BGT7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_008598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000236">
        <property type="protein sequence ID" value="RUS83630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BGT7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS83630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="205" mass="23183" checksum="2C98D013C20D072E" modified="2019-04-10" version="1">MVLARLSGALGAWLTYIPGALNYRDCLAQESVCLLPKNFNNMIIFFKVTNLPLGWKPEALQATYGLHSFVLVKERWWSCRYDIATPRGAIPESASSTGIPCQAASKVNKKEKRSKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKRKKNKEEEDTVNVVDLAQLVSPVNLGWHLQSNMAAPPGLTGPHCSSCLEPAQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BJG1</accession>
    <name>A0A3S1BJG1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA 5'-3' helicase</fullName>
            <ecNumber evidence="9">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_023567</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="9"/>
    <dbReference type="EMBL" id="RQTK01002120">
        <property type="protein sequence ID" value="RUS68670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BJG1"/>
    <dbReference type="STRING" id="188477.A0A3S1BJG1"/>
    <dbReference type="OrthoDB" id="272481at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045951">
        <property type="term" value="P:positive regulation of mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17969">
        <property type="entry name" value="DEAHc_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000381">
        <property type="entry name" value="TFIIH basal transcription factor complex helicase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010643">
        <property type="entry name" value="HBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001945">
        <property type="entry name" value="RAD3/XPD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06777">
        <property type="entry name" value="HBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00852">
        <property type="entry name" value="XRODRMPGMNTD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="7"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS68670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="459" mass="52301" checksum="DB8699464D157D21" modified="2019-04-10" version="1" fragment="single">MKLNVDGLLVYFPYDYIYPEQFLYMQELKRALDAKGHCVLEMPSGTGKTVSLLALITAYMRANPFDVTKLIYCSRTVPELDKVVEELRSLMEYYAQETGEVPNFLGLALSSRKNMCIHPEVSEERDVGIVNGKCHQLTASFVRNRAKSNPNTQICSFYEDFDSNGRNIPLPAGIYGLDDLKEYGRQHGWCPYFLARYAINQAHVVIYSYYYLLDPKIAELVSKELSSQSVVVFDEAHNIDNVCVESMSVKITRRTIDKCNQNIEDLSKQIKSIKQVDENRLKNEYRRMVEGLRETNIARETDMVLANPVVPDEILQEAIPGSIRNAEHFVGFMKRFVEYLKTRLRVQHVVSESPPSFLKDCQSKVCIERKPLRFCSERLSSLLRTLELADIKDYSALSLVAGFATLISTYTKGFSLIIEPFDDRTPSISNPIMNFSCLDATIAIKPIFDRFQSVVVTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BJY3</accession>
    <name>A0A3S1BJY3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_006763</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000168">
        <property type="protein sequence ID" value="RUS85487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BJY3"/>
    <dbReference type="STRING" id="188477.A0A3S1BJY3"/>
    <dbReference type="OrthoDB" id="434771at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02603">
        <property type="entry name" value="HAD_sEH-N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052898">
        <property type="entry name" value="ACAD10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011945">
        <property type="entry name" value="HAD-SF_ppase_IA/epoxid_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02247">
        <property type="entry name" value="HAD-1A3-hyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829:SF3">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="3">
        <location>
            <begin position="283"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="598"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="606"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS85487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="629" mass="70259" checksum="5CF3181223E13C21" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BKY2</accession>
    <name>A0A3S1BKY2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_006107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000149">
        <property type="protein sequence ID" value="RUS86159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BKY2"/>
    <dbReference type="OrthoDB" id="6041129at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS86159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="176" mass="20548" checksum="B53E87A8AFF57B0E" modified="2019-04-10" version="1">MRLLEPDEPCLSREPSMEICRTTGISLNDNLCHNTGVKPKTATIIYPQYDEDPRCPPNRFKELPQIPGEIKRFNKAFDKRQLMKKHHCCLPYLPPAYRPVLPVPPAEWWTHVDMCKPWHYFDRSACCDIARPYNWQNDICPIPYCRPGGKAIPPMVIRYPNLGLYFPPCETFQVKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BNY8</accession>
    <name>A0A3S1BNY8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C-terminal-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_004224</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000094">
        <property type="protein sequence ID" value="RUS88058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BNY8"/>
    <dbReference type="STRING" id="188477.A0A3S1BNY8"/>
    <dbReference type="OrthoDB" id="9991913at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001221">
        <property type="term" value="F:transcription coregulator binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05299">
        <property type="entry name" value="CtBP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000012">
        <property type="entry name" value="C-terminal-binding protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043322">
        <property type="entry name" value="CtBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051638">
        <property type="entry name" value="CTBP_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46029">
        <property type="entry name" value="C-TERMINAL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46029:SF7">
        <property type="entry name" value="C-TERMINAL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="7">
        <location>
            <begin position="40"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="8">
        <location>
            <begin position="136"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="406"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS88058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="47187" checksum="B31229BCBE3801FC" modified="2019-04-10" version="1">MQAGPKKARLEPNTMSIRGPHPNGPIQPRPLVALLDGRDCSIEMPILKDVATVAFCDAQSTHEIHEKVLNEAVGALMWHTINLNKEDLDKFKSLRVIIRIGSGYDNVDVKAAGEMGIAVCNVPGYGVEEVADSTLCLILNLYRRTYWLANMVRDGKKINGPEQLRDAAQGSARIRGDTLGIVGLGRVGTAVALRAKVFGFNVIFYDPYLTDGIEKSLGITRVYTLQELLFQSDCVSLHCNLNEHNHHLINDYTIKQMRPGAFLINTARGGLVDEVALAAALKDGRIRAAALDVQESEPLVYANSSLKDCPNLICTPHSAFYSEQSVTELREMAAGEVRRAILGRIPESLRNCVNKEYFTPTTSSVRYPYPPGGPFADNLNGAAGYPGFNPAVAAVAIHSTTDHPAVSHGGAILSTAHSGPDSGNHVPKPENPSPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BQE5</accession>
    <name>A0A3S1BQE5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_003296</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000070">
        <property type="protein sequence ID" value="RUS88960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BQE5"/>
    <dbReference type="STRING" id="188477.A0A3S1BQE5"/>
    <dbReference type="OrthoDB" id="2129233at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043458">
        <property type="entry name" value="GPR158/179"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32546">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 158-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32546:SF29">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="302"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="307"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS88960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="362" mass="40889" checksum="B4922E524BAD0AB2" modified="2019-04-10" version="1">MRSANRAPVVAATVYATACCVLGISFAISTSIHANSDDYYNDNNATIFSYHVPDDEGNSSFPGDWYLNNLNSSDQDLSDVYEIFNEGKDNSVLVASVDDTDDDRGRNEVEKESDSVENFLQSVEEYSKNKADCIPGTDHNLGSGVIKQYGLNRFQAQAMVAVNRANFLTRIWRYPDSEFLQSEYLFYTQVRNIVEGDPDIFAAGNCYDKGEFKDYHLFCPFSHRTEDGKITVKDLSLEYKYLGNTSEFFFSARMRSSKLENFNFTKGYVQWRYNETSLGPVEEDSIITVTYDDGHWTVPYFDCGGGGDDDDDDDDDDDDDDDDDDDDEEEEEEEEEEEEEDDEVFVAAADFGALVLCPCAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BRT8</accession>
    <name>A0A3S1BRT8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_002322</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000045">
        <property type="protein sequence ID" value="RUS89881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BRT8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018587329" evidence="2">
        <location>
            <begin position="23"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS89881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="260" mass="28899" checksum="09C4C7DCAA962BA5" modified="2019-04-10" version="1">MALLRFSVSVLCWAATLTLVHCAGDLTLWKYSSPLSGNLRRAGIPPTVDVDTPQALSSDGEPQELQLARILAERSWENPPDNNAFVLRRSPEPSWGLISQVKRGGSGEDESESESRILDFSDLREKLEDATNFGELGTSSRVYRSMRNPITKRQRITQGGSENASSPAQSYGSSLEVLKRLFSFLRRNPHGKSPRIVSPMALSRSHRNSRLVEAAPRMCRGSLRCFRRQTVEVNGDARQTKKNGPWPSSYLLGGAMGKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BSC7</accession>
    <name>A0A3S1BSC7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_001849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GOLGA6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000034">
        <property type="protein sequence ID" value="RUS90354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BSC7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026737">
        <property type="entry name" value="GOLGA6L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23143:SF31">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 6-LIKE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23143">
        <property type="entry name" value="TRICHOHYALIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS90354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="178" mass="22157" checksum="DBCCEBAD9A0BDD95" modified="2019-04-10" version="1">MCYFDHVRRYCDHVMRYCDDVMCYCDHVMRYCDHVRRYCDHVMRYCDHVRRYCDHVRRYCDHVMRYCDHVMRYCDHVMRYCDHVMRYCDHVRRYCDHVMRYCDHVMRYCDHVMRYCDHVMCYCDHVMRYCDHVMCYCDDVMCYCGHVMCYCGHVDGKVCNVTVSTMGRKTHGLHVTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BT89</accession>
    <name>A0A3S1BT89_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Reverse transcriptase RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_017924</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000843">
        <property type="protein sequence ID" value="RUS74315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BT89"/>
    <dbReference type="STRING" id="188477.A0A3S1BT89"/>
    <dbReference type="OrthoDB" id="6147315at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34072">
        <property type="entry name" value="ENZYMATIC POLYPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34072:SF52">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="7">
        <location>
            <begin position="132"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS74315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="251" mass="28556" checksum="9B311CC58ECC0F3D" modified="2019-04-10" version="1">MHSAQVSRTERLSATATSLLSPKLTGSLSRCGLVLATKMPCAESRNGVEIRVQTILLRLFYMWRYEDECLRAEGKREADIRLTIGRSLRFYGLKQGQAEDAGSFAARLEDVILQAVQLGRVRREDVDPLLKVTKHFELHIDASEAGLRAILCQLVDGTEKIIAHASRALHKSEARSQTHKLDFLCLKWSICNKFKDYLWEAPKFLVRSDNNPLIYVLTTAKLDATGHRWLSALVAFDFEIEYTPKRFESRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BUQ6</accession>
    <name>A0A3S1BUQ6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="10">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EGW08_003029</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">EC2010</strain>
            <tissue evidence="16">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10 13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10 13">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="10"/>
    <dbReference type="EMBL" id="RQTK01000062">
        <property type="protein sequence ID" value="RUS89219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BUQ6"/>
    <dbReference type="STRING" id="188477.A0A3S1BUQ6"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006739">
        <property type="term" value="P:NADP+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000002">
        <property type="entry name" value="Isocitrate dehydrogenase [NADP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004790">
        <property type="entry name" value="Isocitrate_DH_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00127">
        <property type="entry name" value="nadp_idh_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006156">
        <property type="entry name" value="PRK08299.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822:SF21">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
        <property type="entry name" value="NADP-SPECIFIC ISOCITRATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000108">
        <property type="entry name" value="IDH_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="6 10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 14" id="KW-0521">NADP</keyword>
    <keyword evidence="8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="8"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="74"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="93"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="309"/>
            <end position="314"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="11">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="11">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RUS89219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="412" mass="46196" checksum="AA2E41D03405374D" modified="2019-04-10" version="1">MGKIKGGPVVEIQGDEMTRIIWDQIKEKLILPFVDLDIHFFDLGIENRDATDDQVTIDCAEAIKKYNVGIKCATITPDENRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVPGWTKSIVIGRHAFGDQYRATDFVVPGPGKVTMKYEPAQGGATQEFTIFDFEESGGVAMGMYNTDKSITDFAHSSFQFALQKEWPLYLSTKNTIMKKYDGRFKDIFQDIYEKQYRKDFEAKGIWYEHRLIDDMVAYCMKSDGGFVWACKNYDGDVQSDSVAQGFGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHFRFHQQGKETSTNSIASIFAWTRGLAHRAKLDSNAELTKFAENLEAVCVETIESGIMTKDLAICVKGMSSVTRADYQTTFEFLDSLAANLTKKMSASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BZB3</accession>
    <name>A0A3S1BZB3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MD-2-related lipid-recognition domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_013440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000489">
        <property type="protein sequence ID" value="RUS78790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BZB3"/>
    <dbReference type="STRING" id="188477.A0A3S1BZB3"/>
    <dbReference type="OrthoDB" id="6409159at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006689">
        <property type="term" value="P:ganglioside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.220.10">
        <property type="entry name" value="Ganglioside GM2 activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028996">
        <property type="entry name" value="GM2-AP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036846">
        <property type="entry name" value="GM2-AP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17357:SF0">
        <property type="entry name" value="GANGLIOSIDE GM2 ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17357">
        <property type="entry name" value="GM2 GANGLIOSIDE ACTIVATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63707">
        <property type="entry name" value="Ganglioside M2 (gm2) activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018541357" description="MD-2-related lipid-recognition domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="3">
        <location>
            <begin position="24"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS78790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="208" mass="22539" checksum="7F17A66BD28FC03A" modified="2019-04-10" version="1">MELASVLRILVWTALFATSHGVKIQSCSGNPSADIVTVNYYSAQPDPLQIPGDVRTSASFTVHRPITGDLKLDITLSRKLGVMWLDLPCVKTSMGRLGSCSYRKFCDVIAQANSTGMCPNILTSNKIPCACPISAGTYTIPQTVVNINTDFLQLPASVFSGDYLTSIRLTDMSTRKEIMCYDVELTIADPPSGKTFGSLGRFLVNLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C0R1</accession>
    <name>A0A3S1C0R1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_012439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000427">
        <property type="protein sequence ID" value="RUS79792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C0R1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS79792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="281" mass="31383" checksum="6D4A23C054BCE693" modified="2019-04-10" version="1">MERRRLRPPAACSSRNSHTRGWDIILETLKKRDKKKIERNYNINNTEVLVIFYNDNNNNNNNNNNNNNNNNNNNNNNNKAGHNVAGRMSKVLVGFEEINRSLTRICHRPLISIEKNGADDDEDDDDDDDDDDDDDDDDDDDDDDADDDEDSADNNCSASTATAAAVTMNMLMILKLKYMFIGMGDEVMSTCNNQTQSCSGAPSEFSRLAQFKNFLASPYRPAGCSSRDVLQIVTGATRDGRATGGFGVGNSLRFECMQVDQFLREQLKTVLGEGRLAPGCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C2R7</accession>
    <name>A0A3S1C2R7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_010940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000345">
        <property type="protein sequence ID" value="RUS81298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C2R7"/>
    <dbReference type="STRING" id="188477.A0A3S1C2R7"/>
    <dbReference type="OrthoDB" id="444601at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF9">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="1">
        <location>
            <begin position="2"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS81298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="319" mass="35335" checksum="14CCD26212F7FDE3" modified="2019-04-10" version="1">MLNKLHKRHLGVTKCCALAHTSVWWPNISPQIEYMVNKCSTCATLRPPMKEPLLPFSFHEHPLSRVAVDLFDLLGKTCLLLFDYHFRWQKLRLLDRITGSSTSNITRLRSVFATHGIPDIAVSASVFHLPRVQRQCSTCPGYSVSVPPAPGTASVFHLPRVQRQCSTCPGYSVSVPPAPGTALRHHLPRVQRQCSTCPGYSVSVPPEAPPVPGTASVFHLRHHLPRVQRQCSTCPGYSVLRHHLPRVQRQCSTCPGYSVSVPPAPGTASVFHLPRVQRQCSTCPGYSVSVPPEAPPAPGTASVFHLRHHLYRVQQDRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C3A2</accession>
    <name>A0A3S1C3A2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_010498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000322">
        <property type="protein sequence ID" value="RUS81744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C3A2"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018600371" evidence="1">
        <location>
            <begin position="28"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS81744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="114" mass="12285" checksum="29F00ABAE005581D" modified="2019-04-10" version="1" fragment="single">MTLIHQCIPCVCQGILTLIYQCIPCVCQGVLTLICQCIPCVCQGILTLICQCIPCVCQGILTLICQCIPCVCQGILTLICQCIPCVCQGILTLICQCIPCVCQGILTLIYQCIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1CGA9</accession>
    <name>A0A3S1CGA9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_000438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000005">
        <property type="protein sequence ID" value="RUS91867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1CGA9"/>
    <dbReference type="OrthoDB" id="6128171at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018661870" description="VWFC domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS91867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="27377" checksum="B705459DB847FF9C" modified="2019-04-10" version="1" fragment="single">MARVAMVIISLASMNMLLSVHVHSATVRSSTPTERFFTGSFDRGMCEIQGLYPRDRNSFDRGDITRQYHLGQFWTDRCNNCTCTTSGPMCRGPGSKCLHWYDFSQEDWCIKWSDDGCCCEKLGCTVGNTTYELGEQVPYGDGNPCLTCQCQVGSTREHCLWQQCGKVELQCDQRTVTYDECCPTYNCPNGVFCNDIPDPYPETPHHELRNWYAGRLEPIPMGTTQHFHLDSWTTYKCTCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1GZZ5</accession>
    <name>A0A3S1GZZ5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_022730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001659">
        <property type="protein sequence ID" value="RUS69513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1GZZ5"/>
    <dbReference type="OrthoDB" id="10638947at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS69513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="262" mass="28639" checksum="4BC03846C0181D31" modified="2019-04-10" version="1">MDIKGYTVECGKPASNMTPVEEAAMKDKETPKLSRKGSSGNLLRTVSKLMVLDVKIKSKAHQKAASAKSALAKKKASGKGESADTKKGVTFAEETKPPDEDQEQGEDFLPTLEEDETEEGDKSTDDKKDDNEENAVGATEEGVKGEEGAENQQTEGSEDKEKMPEEDEEEKKGGKKGKKKAKTKKDKREEARRRAAAKKEAEQPHSLNVIPPEYPQDFQKTAESGSRVVWLQRSRFSPSVRDVCLSSAALAVSCPLLRRGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H2S9</accession>
    <name>A0A3S1H2S9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glyoxylate reductase/hydroxypyruvate reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_021159</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001276">
        <property type="protein sequence ID" value="RUS71081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H2S9"/>
    <dbReference type="STRING" id="188477.A0A3S1H2S9"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008465">
        <property type="term" value="F:hydroxypyruvate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05301">
        <property type="entry name" value="GDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000026">
        <property type="entry name" value="Glyoxylate/hydroxypyruvate reductase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF277">
        <property type="entry name" value="GLYOXYLATE REDUCTASE_HYDROXYPYRUVATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="4">
        <location>
            <begin position="13"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="5">
        <location>
            <begin position="115"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00073306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS71081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="328" mass="35093" checksum="BD9703CD22FA027A" modified="2019-04-10" version="1">MSSPSQLPKVWVARTFPPEGMAKLATKCHVVVHEGALAPSRQEILDGVRGAHALFIYPHVKVDKELLDTAGQQLKVIGTFSVGLDHIDLDLCKERGIKIGYTPDVLTTSTAEQAITLVMATARRMGECISSVKEGVWGTTWDNAMWLAGAEISGSVIGMVGLGRIGLAIAKRLAAFEVSKILYTGRNPKPELANPIGAEFVTFDQLLEQSDFVIVACSVNDSNKGLFDEAAFKKMKRSAILVNISRGVVIDQDALYDALKSGEIGAAGLDVTTPEPLPPSSPLLALPNCLVTPHIASCTVTTRNAMCDLVVENIFAGLEGRPLKTPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HEE6</accession>
    <name>A0A3S1HEE6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_014611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000565">
        <property type="protein sequence ID" value="RUS77636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HEE6"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS77636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="163" mass="19264" checksum="549344AFC4B5E2BC" modified="2019-04-10" version="1" fragment="single">FIRLSILTVFLFLRLSFLRLPILTFVYSYVCLFLRLSVLTFFYSYVCLFLRLSILTFVYSYVCVFLRLSILTFVYSYACLFLRLSIIKFVYFYVCLFLCLSILTFVSSCVCLFLRLSILTFVYSYVCLLSRLSISTFVCSYVCLFFVSIMTKYVSHILCIFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HJ71</accession>
    <name>A0A3S1HJ71_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_011730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000387">
        <property type="protein sequence ID" value="RUS80509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HJ71"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS80509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="523" mass="57208" checksum="3BE0812CC1264F63" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HKA1</accession>
    <name>A0A3S1HKA1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_011013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000349">
        <property type="protein sequence ID" value="RUS81219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HKA1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="277"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS81219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="458" mass="49165" checksum="8D59EAFAB67F00F0" modified="2019-04-10" version="1" fragment="single">RKPSQRQTLGTNECWGKSSTSKNVSNQVSDLRSSDVRENQVNDQQCDRMMEPDSGHNKSGGVVVTSPSSSSNRSIFRSSKPRRSLQETISAFTASPKTRHILGAPTPKRTGRSSSSCAVVAKVAPLDKISGSTATSDKSELSGTKYRPPAPNPARHLANANKSGSSDQRVKQPDKKLSPLFHPVMTRLVGYSLGNASAASTGNTVVPKGILKAPQCGSAQTKSVRFPSQLEIHMKGLTQESQDGQMSSPPVAERSLSNMFETGSKQPQTSQLTLPAQTPQSTQLSQLTKPSQSTQPQQLPHSPQLPLPSQLALPPQPQLPRPLHQTAETPQHKAADEGKSQTPDNQESSVKGSALRTVTSPDSCESLSCTFTNKNLSSEATFPGQQCNQDHRNVTLHVSDSEMQCPATVIPETPNLSGLTQGPWKESDLSPRIEQPVPGRDSDLSPPPKCKKPKLCSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HSP4</accession>
    <name>A0A3S1HSP4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_006886</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000173">
        <property type="protein sequence ID" value="RUS85343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HSP4"/>
    <dbReference type="STRING" id="188477.A0A3S1HSP4"/>
    <dbReference type="OrthoDB" id="10036964at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="25"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS85343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="336" mass="38248" checksum="1CA5A38911E86E51" modified="2019-04-10" version="1" fragment="single">MSPPAYMYAYVTVINVIIFVVGVIGNVMVLLVIVRMRALRTRVNYFLASLRVSDLLVLIVCQPSAMLSFYAQDKWLLGHFMCKLVPFLEHWTVHASVLTLLVIGIDRYVTICRPGSALFPARPVLYLCVVWLTAGVLSLPFVFLTSVEEELYHDGTLVEVCRTKLVSLRSRMFVAFTFAFMFFFPLVLLCFLYFSVISRLRRLAVSHDTMTSVGGKVKGYRADDVRSSHSTWVGWLVGWLAALLTPGRPRLVNPATARSRHQVARMLLVIVTLFAVCFTPFKVLTLWLAFEETSRVQRLGFETFLNILSLCQMLTYFNSAGNPIIYAWMSPRFRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HTB4</accession>
    <name>A0A3S1HTB4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">TGF-beta family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_006566</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TGF-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000162">
        <property type="protein sequence ID" value="RUS85690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HTB4"/>
    <dbReference type="STRING" id="188477.A0A3S1HTB4"/>
    <dbReference type="OrthoDB" id="5987191at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000001">
        <property type="entry name" value="Bone morphogenetic protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001111">
        <property type="entry name" value="TGF-b_propeptide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017948">
        <property type="entry name" value="TGFb_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF263">
        <property type="entry name" value="PROTEIN DECAPENTAPLEGIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00688">
        <property type="entry name" value="TGFb_propeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00669">
        <property type="entry name" value="INHIBINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00250">
        <property type="entry name" value="TGF_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0339">Growth factor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="TGF-beta family profile" evidence="10">
        <location>
            <begin position="589"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="101"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="183"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="376"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="530"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="553"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="579"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS85690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="709" mass="77525" checksum="1BF5932CD419527B" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1I436</accession>
    <name>A0A3S1I436_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL4 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_000398</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000005">
        <property type="protein sequence ID" value="RUS91827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1I436"/>
    <dbReference type="STRING" id="188477.A0A3S1I436"/>
    <dbReference type="OrthoDB" id="10259785at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1370.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025755">
        <property type="entry name" value="Ribos_uL4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013000">
        <property type="entry name" value="Ribosomal_uL4_euk/arc_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045240">
        <property type="entry name" value="Ribosomal_uL4_euk/arch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19431">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14374">
        <property type="entry name" value="Ribos_L4_asso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00939">
        <property type="entry name" value="RIBOSOMAL_L1E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL4 C-terminal" evidence="5">
        <location>
            <begin position="274"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="352"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS91827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="393" mass="44673" checksum="13A9D89EC0D81DCC" modified="2019-04-10" version="1">MASRPLISVHNEKGETTDVNVVLPAVFKAPIRPDIVNTVHFQMLKNTRQPYAVSEKAGHQTSAESWGTGRAVARIPRVRGGGTHRSGQGAFGNMCRGGRMFAPTKTWRRWHRKINVNQRRYAITSAIAATGVPALVMSKGHRIEEIPEVPLVVSDKVQEIKKTKEAVAVLKKLKAWSDIEKVYNSKRFRAGKGKMRNRRRIQRRGPLVIYDQDNGISRAFRNIPGITLISVDRLNLLKIAPGGHVGRFCIWTESAFKRLDNIYGTWRTESKEKKGYNLPMHKMASFDLARLLKSDEIQSVIRAPKKEVKRRILKKNPLKNYRVMVRLNPYEKHAKKEAKHIETMRKRAKEELLNKRRGIKKPLEPLPKGKSAAKKAKRVAKVAALKGKKTTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SID3</accession>
    <name>A0A433SID3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_023547</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01002097">
        <property type="protein sequence ID" value="RUS68692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SID3"/>
    <dbReference type="STRING" id="188477.A0A433SID3"/>
    <dbReference type="OrthoDB" id="361630at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02134">
        <property type="entry name" value="KH-II_NusA_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22529">
        <property type="entry name" value="KH-II_NusA_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.20:FF:000002">
        <property type="entry name" value="Transcription termination/antitermination protein NusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.20:FF:000005">
        <property type="entry name" value="Transcription termination/antitermination protein NusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1480.10">
        <property type="entry name" value="NusA, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00945_B">
        <property type="entry name" value="NusA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058582">
        <property type="entry name" value="KH_NusA_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036555">
        <property type="entry name" value="NusA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010213">
        <property type="entry name" value="TF_NusA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030842">
        <property type="entry name" value="TF_NusA_bacterial"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025249">
        <property type="entry name" value="TF_NusA_KH_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013735">
        <property type="entry name" value="TF_NusA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010214">
        <property type="entry name" value="Tscrpt_termin_fac_NusA_C_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01953">
        <property type="entry name" value="NusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01954">
        <property type="entry name" value="nusA_Cterm_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22648">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR NUSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22648:SF0">
        <property type="entry name" value="TRANSCRIPTION TERMINATION_ANTITERMINATION PROTEIN NUSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13184">
        <property type="entry name" value="KH_NusA_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26594">
        <property type="entry name" value="KH_NusA_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08529">
        <property type="entry name" value="NusA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69705">
        <property type="entry name" value="Transcription factor NusA, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="112"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS68692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="465" mass="52094" checksum="0A78B3386BDDF0B0" modified="2019-05-08" version="1">MEEALAIVTKKELDERMNIEVKIDRETGDYTADRVWHIVSEDEDLIDYSKELYEDVAIEKGYDVKAGDVIRESVEVVGFGRIAATMAKQILMKKIKNFEREKSARFYQTKLGTIVYGEVKRATYDILVIDLGNNAEGILAKKDLIARERFRVGDKVRSCVEAIECDEFGTPNTIVLSRASDTMLKALFELEVPEVEEDLINIVNVVREPGFRSKVSVKSNDRRIDPCGACVGVRGSRIHSIMGELNGEKVDVILWDEESVQYAINSLSPVAAEDVLEVNVDEETASMDIVVKQESLSRAIGRNGVNVRLASALIGWRINVLSDSEQEEKQVSIVEMFVEVLDVDEDFALVLIEEGIETLEDLAYLDRDELVEIEGFDEDIVDELQERAKAAILARALGSKEPAQDLLDMENMNDELAQKLASSDIATMSDLADLSVDELQEIVEISEEAATNLIMEARAPWFETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SIP7</accession>
    <name>A0A433SIP7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_023614</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01002189">
        <property type="protein sequence ID" value="RUS68624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SIP7"/>
    <dbReference type="STRING" id="188477.A0A433SIP7"/>
    <dbReference type="OrthoDB" id="10059790at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF25">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019206580" description="Reverse transcriptase domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="263"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="381"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS68624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="641" mass="69955" checksum="CB8D268E89AA2CC8" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SIR8</accession>
    <name>A0A433SIR8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alpha-macroglobulin-like TED domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_023359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001952">
        <property type="protein sequence ID" value="RUS68880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SIR8"/>
    <dbReference type="STRING" id="188477.A0A433SIR8"/>
    <dbReference type="OrthoDB" id="9998011at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF146">
        <property type="entry name" value="CD109 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-macroglobulin-like TED" evidence="1">
        <location>
            <begin position="3"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS68880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="151" mass="17419" checksum="21B651B440BED436" modified="2019-05-08" version="1">MTMSWLNTMRNSFAGFSSTQDTIVALEALSLYASQDPNRNEFGLDLSLTASSDQNWEQDIHIPKNDFTRVYRSYLQENHVFGFIRSDTKGVGRAMLQLTTTKRVEFQKLVKTPMYIDNDLSKTPMKFFSLDLQINFAGRNNSIMLMRPCVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SN72</accession>
    <name>A0A433SN72_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_021575</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001358">
        <property type="protein sequence ID" value="RUS70667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SN72"/>
    <dbReference type="STRING" id="188477.A0A433SN72"/>
    <dbReference type="OrthoDB" id="5957871at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004989">
        <property type="term" value="F:octopamine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15065">
        <property type="entry name" value="7tmA_Ap5-HTB1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF187">
        <property type="entry name" value="OCTOPAMINE RECEPTOR BETA-2R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="313"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="55"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="281"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS70667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="443" mass="49549" checksum="29B240BFF6E1E79E" modified="2019-05-08" version="1">MELYSQMTTSVFNSTASPMNFDNTTDDPAAPGNPIGRKIALGIFFGLTILTAIGGNLLVCTAVFTERRLKRNKNNYFIVSLAVADLFVACVVMTFAMANDIQQKWMFGGIFCRIWISFDIMCSTASILNLCVISLDRYIHIQNAMYYDTWMTTRKALMFIASVWFLSALISFLPIHLGWHQNGYSSESPVSNVTEVSVGTDHGNQTHNATYSIDSQSSGVDISNDSDEMCIIELNFIYAIVSSTISFYAPCVVMLVLYFKLFLFARRHAVSIRSMKRPAMPADLSSASSTPDRRKTMTNGSTRSSIRASDHKAAFTLGVITGVFLCCWLPFFVINPIAAYNPNLIHPNAFVASTWLGYVNSCLNPIIYSIFNTEFREAFKRILCVRILRRDSWNYLPGLSAGNGNARTNKFKKSDYTDNGNGAVSRKTSRDLLFNEKEKVTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SP28</accession>
    <name>A0A433SP28_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA 3'-terminal phosphate cyclase</fullName>
            <ecNumber evidence="2">6.5.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">RNA terminal phosphate cyclase domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_021259</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. Likely functions in some aspects of cellular RNA processing. Function plays an important role in regulating axon regeneration by inhibiting central nervous system (CNS) axon regeneration following optic nerve injury.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 3'-end 3'-phospho-ribonucleotide-RNA + ATP = a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23976"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.4" evidence="2"/>
    <dbReference type="EMBL" id="RQTK01001292">
        <property type="protein sequence ID" value="RUS70977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SP28"/>
    <dbReference type="STRING" id="188477.A0A433SP28"/>
    <dbReference type="OrthoDB" id="25029at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003963">
        <property type="term" value="F:RNA-3'-phosphate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.20:FF:000002">
        <property type="entry name" value="RNA terminal phosphate cyclase-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00200">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013791">
        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017770">
        <property type="entry name" value="RNA3'_term_phos_cyc_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020719">
        <property type="entry name" value="RNA3'_term_phos_cycl-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03399">
        <property type="entry name" value="RNA_3prim_cycl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF0">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05189">
        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005378">
        <property type="entry name" value="RNA3'_term_phos_cycl_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52913">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, RPTC, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01287">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="11">
        <location>
            <begin position="27"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase insert" evidence="12">
        <location>
            <begin position="201"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="9">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="310"/>
            <end position="314"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005378-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005378-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS70977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="387" mass="40758" checksum="CC608185DBF10AA1" modified="2019-05-08" version="1">MSDMIPKERPVQEFDSDGRIVIDGSLLEGGGQILRNAAALSCILGIPIRVVKIRAGRSKPGLRPQHMTGLNLVARLCGGNLQHCQVGSCEITLDPGPIQAGQFVADTGTAGSICLLMQVAVPCIVFACSDCSLTLKGGTNCDMAPQIDYTTMIFKPIAEKFGMHFDINIKRRGYYPKGGGEVVVTSQPCSGLDALPEDLTTRGEVVRVYSRSFVAGNLPPHLANKVSTTIAKTVKQNFPTAELQQDSLREPDGAAIGSGLGTMIVAETSTGCLFGGSALGKPRTPAEDTGKAAVGDLLDGTSTGGAVDQYLQDQLILLMTLAKGQSRILCGPLTLHTQTAIHIARLLTKAEFSLEPVKSDEGKETCMLVCEGIGHVNPHLNSAAESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433STB6</accession>
    <name>A0A433STB6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_019707</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001057">
        <property type="protein sequence ID" value="RUS72525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A433STB6"/>
    <dbReference type="OrthoDB" id="10255969at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002470">
        <property type="entry name" value="ABC transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056264">
        <property type="entry name" value="R2_ABCA1-4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF266">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 12-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23321">
        <property type="entry name" value="R1_ABCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2517"/>
            <end position="2547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2568"/>
            <end position="2589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2595"/>
            <end position="2620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2632"/>
            <end position="2653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2704"/>
            <end position="2726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="3047"/>
            <end position="3065"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="3133"/>
            <end position="3155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="3176"/>
            <end position="3201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="3213"/>
            <end position="3234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="3246"/>
            <end position="3269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="3289"/>
            <end position="3310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="3331"/>
            <end position="3352"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="2678"/>
            <end position="2911"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="3394"/>
            <end position="3640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="3722"/>
            <end position="3750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="3767"/>
            <end position="3802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="3727"/>
            <end position="3744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="3773"/>
            <end position="3788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS72525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="3802" mass="421978" checksum="DAD2B9551A0E6019" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SVB9</accession>
    <name>A0A433SVB9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">EGW08_019051</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">EC2010</strain>
            <tissue evidence="20">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 22">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 22">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="RQTK01000967">
        <property type="protein sequence ID" value="RUS73189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A433SVB9"/>
    <dbReference type="OrthoDB" id="10030361at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14211">
        <property type="entry name" value="STKc_HIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000029">
        <property type="entry name" value="Homeodomain-interacting protein kinase 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000022">
        <property type="entry name" value="Homeodomain-interacting protein kinase 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF17">
        <property type="entry name" value="HOMEODOMAIN INTERACTING PROTEIN KINASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="290"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="232"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="898"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1028"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1188"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1303"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1378"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1478"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="898"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="1055"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1188"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1306"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1381"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RUS73189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1564" mass="170007" checksum="C542681F4D179F5C" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SX93</accession>
    <name>A0A433SX93_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">T-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_018312</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000885">
        <property type="protein sequence ID" value="RUS73922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SX93"/>
    <dbReference type="STRING" id="188477.A0A433SX93"/>
    <dbReference type="OrthoDB" id="7442607at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20187">
        <property type="entry name" value="T-box_TBX1_10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.820:FF:000007">
        <property type="entry name" value="T-box transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.820">
        <property type="entry name" value="Transcription factor, T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046360">
        <property type="entry name" value="T-box_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036960">
        <property type="entry name" value="T-box_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001699">
        <property type="entry name" value="TF_T-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018186">
        <property type="entry name" value="TF_T-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267:SF195">
        <property type="entry name" value="OPTOMOTOR-BLIND-RELATED-GENE-1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267">
        <property type="entry name" value="T-BOX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00907">
        <property type="entry name" value="T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00937">
        <property type="entry name" value="TBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00425">
        <property type="entry name" value="TBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01283">
        <property type="entry name" value="TBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01264">
        <property type="entry name" value="TBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50252">
        <property type="entry name" value="TBOX_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="T-box" evidence="8">
        <location>
            <begin position="68"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="267"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="326"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS73922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="406" mass="45322" checksum="73B4B4B5E6AD2A7F" modified="2019-05-08" version="1" fragment="single">QHSSPGLDTSAGSPGDNAGSDATDTPESGRATLPTLSTVAPGGGGPKSEPAPPSEPLHYKLLHVECKLEMKALWDRFDSLGTEMIVTKLGRRMFPTFQVRLFGLDPNSDYNVQMDFEPVDDKRYRYSFPTSCWVVAGKADTHMPPRRHVHPDSPAKGHQWMKQIITFDKLKLTNNLMDINGYIILNSMHKYQPRLRVLYRPGKGEQTDGVCLYRTFIFQETKFMAVTAYQNQSITRLKIDSNPFAKGFRDCDQNDCLGMSDFLPINSGCPPRPRPQPRPPHSSANFQLGLLAGSPRRKESPSAEEIQSGQTSMTSSLTPMTPPLTPMASMSSMPMLPSPLQASRPGQLYTDCYPYPPYSDAYMNSSKSRPSPYAYPMDYPATYSPRVKGLYSPQRTNSYAYGYESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SX95</accession>
    <name>A0A433SX95_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_018300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000883">
        <property type="protein sequence ID" value="RUS73943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SX95"/>
    <dbReference type="OrthoDB" id="2506647at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS73943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="457" mass="49599" checksum="8E5DF2AE77B9D58F" modified="2019-05-08" version="1">MSSLSYLINSPYTFMVFEQTARIPIQTAQQAVQITTFEGFASATSSPVGAFYISSLLQKLSAYVDTNMKFATIMEMYPDPYGSYRSTFFFSSADLCPAYYSQLPDHFTWAMAVAPFLTSTTVHVHVTYETDDVTDTACCKQFQLSRGSHMVSALDSRPVRAGMTRDAPRIFLSPLFLLGRTAGREGISGEITDQSLSVADMTILTYLLGVYGITDISLSVDGITDLSLSVDDITDLSLSVDDITELSLNVDDNTDLSLSVDGITDEPIALMFLLFQHSISVDPRTISDICSNETTTCTAQISDFGTKMGLGDIAGVNWVIVEEDGFSVKVDAVVILVVVAVVVVVVVVVVVVVVVVVWETSPGCTAQISDFVTKMGLGDIAGVNWVIVEEDGFSVKYQYTEMGRSEADVCRTRGGYFKPCLDQQPCSAIGQFGFGHPLLTSVLAALVISLHYTRRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-05-03" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SXA0</accession>
    <name>A0A433SXA0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_018269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000880">
        <property type="protein sequence ID" value="RUS73969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SXA0"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS73969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="308" mass="34518" checksum="9221232EC9E70C00" modified="2019-05-08" version="1" fragment="single">LDPLTLQLCSRLMLDPLTLQLCSRLTLDPLTLQLCSRLTLNPLTLQLCSRLTLDPLTLQLCSRLTLNPLTLQLCSRLTLNPLTLQLCSRLTLNPLTLQLCSRLTLNPLTLQLCSRLTLNPLTLQLCSRLTLNPLTLQLCSRLTLDPLTLQLCSRLTLNPLTLQLCSRLTLNPLTLQLCSRLTLNPLTLQLCSRLTLNPLTLQLCSRLTLNPLTLQLCSRLTLNPLTLQLCSRLTLDPLTLQLCSRLMLDPLTLQLCSRLTLNPLTLQLCSRLTLNPLTLQLCSRLTLNPLTLQLCSRLTLNPLTLQLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SZ25</accession>
    <name>A0A433SZ25_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_017670</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000819">
        <property type="protein sequence ID" value="RUS74564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SZ25"/>
    <dbReference type="STRING" id="188477.A0A433SZ25"/>
    <dbReference type="OrthoDB" id="445362at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="104"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS74564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="174" mass="19207" checksum="5E4D8AC2C4C86E1B" modified="2019-05-08" version="1" fragment="single">MYRALYAHNSKLPKYLSFEPGDKFTLVDTSVSDQWFLAQNGLGEIGYVPFNYIKKVEASTEQQVKFIDGAMEAIHLQATSEGGQYTKEQRLIMKKLVKHRAEVIKSAKDVRSSTRRRPAPAPPVVQGAGDDTPSPTTKRGQGSGEGRKTHDDSPSQSHSTKVKNSDARRGSVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SZ59</accession>
    <name>A0A433SZ59_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_017788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000830">
        <property type="protein sequence ID" value="RUS74450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SZ59"/>
    <dbReference type="OrthoDB" id="10673733at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="735"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="787"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="839"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="975"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="847"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="874"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="911"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="980"/>
            <end position="992"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS74450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1001" mass="111070" checksum="5E29409C2777089D" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SZ87</accession>
    <name>A0A433SZ87_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_017644</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000816">
        <property type="protein sequence ID" value="RUS74602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SZ87"/>
    <dbReference type="STRING" id="188477.A0A433SZ87"/>
    <dbReference type="OrthoDB" id="446173at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070593">
        <property type="term" value="P:dendrite self-avoidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000004">
        <property type="entry name" value="DCC isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000001">
        <property type="entry name" value="semaphorin-5A isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044004">
        <property type="entry name" value="TSP1_spondin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF100">
        <property type="entry name" value="FASCICLIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19028">
        <property type="entry name" value="TSP1_spondin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="33"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="123"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS74602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="376" mass="40747" checksum="FA5C20FD804524A4" modified="2019-05-08" version="1" fragment="single">MKDDAGEYTCVATNPASEQFVTSSARVIIKVPPSVVVPPGDRAVRIAEKALLDCQFSGDPAPQIIWTKNGRPVALSDRIQKLDNGSLVIYDLLSSDAGHYKCIAINDAGTSEAQSILTVKSEPKFTIEPVAALVQLGESVIFDCAAEGVPEPTMYWWKGTQRLDTGGRVAVLANNSLRIVATQQSDVGLYRCFATNALGKTFVETQLDVVVHGGYSEWSPWGACSSSCGRGERLRTRTCDSPAPGNGGRDCVGPSTEYATCTMELCPVDGRFSEWSAWSECSKTCGQAVKKRVRECIQPSHGGRHCRGDTVELMDCLLDPCSKWGEWGAHGLSEWSAWSECSKTCGQAVKKRVRECIQPSHGGRHCRGDTVELMDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SZ99</accession>
    <name>A0A433SZ99_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CDC20/Fizzy WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_017582</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000811">
        <property type="protein sequence ID" value="RUS74649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SZ99"/>
    <dbReference type="STRING" id="188477.A0A433SZ99"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF8">
        <property type="entry name" value="FI02843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="9">
        <location>
            <begin position="202"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="248"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="331"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="463"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="17"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS74649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="527" mass="57755" checksum="49E24F91FBE373F0" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T2M7</accession>
    <name>A0A433T2M7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_016429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000710">
        <property type="protein sequence ID" value="RUS75802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T2M7"/>
    <dbReference type="STRING" id="188477.A0A433T2M7"/>
    <dbReference type="OrthoDB" id="430436at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051170">
        <property type="term" value="P:import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05250">
        <property type="entry name" value="CC3_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097:SF7">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019258308" description="NAD(P)-binding domain-containing protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS75802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="30075" checksum="E84B52D62AA61330" modified="2019-05-08" version="1">MRAVPVAALAVLLGILLVWINSDTGDSQAQCRMAPDGETERDMARFKAENHSAFVVGYTGEIGKALVRDLSKLQIFKRVVLMGRRQVELDVGPGIEQKIVNFDKLDEHADLFTGLDVGFCCLGTTRGKAGKEGFVKVDRDYVLATARVSKAQGCRQFGLISSTGADVNSFMLYSKTKGEAEAGVTQIGFERLSIYRPGALLCKREEFRLGERILYVLLAPVFYLFPTSLSIPVESVARAMVNHVVAPLGGSGPQTSIYFNKETHEASGLHPRGCAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T305</accession>
    <name>A0A433T305_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chromatin accessibility complex protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">DNA polymerase epsilon subunit p15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_016329</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1. Does not enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer with POLE3; binds to DNA. Component of the CHRAC ISWI chromatin remodeling complex at least composed of SMARCA5/SNF2H, BAZ1A/ACF1, CHRAC1 and POLE3; the complex preferentially binds DNA through the CHRAC1-POLE3 heterodimer and possesses ATP-dependent nucleosome-remodeling activity. Within the complex, the heterodimer with POLE3 interacts with SMARCA5/SNF2H; the interaction is direct and enhances nucleosome sliding activity by the SMARCA5/SNF2H and BAZ1A/ACF1 interaction. Within the complex, the heterodimer with POLE3 interacts with BAZ1A/ACF1; the interactions are direct.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000701">
        <property type="protein sequence ID" value="RUS75916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T305"/>
    <dbReference type="STRING" id="188477.A0A433T305"/>
    <dbReference type="OrthoDB" id="1291358at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22924">
        <property type="entry name" value="HFD_CHRAC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000048">
        <property type="entry name" value="Chromatin accessibility complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF54">
        <property type="entry name" value="CHROMATIN ACCESSIBILITY COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="13">
        <location>
            <begin position="9"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00062516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS75916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="105" mass="11590" checksum="352E8B3F23919AC1" modified="2019-05-08" version="1">MASPGGSTSLPLSRVKTIMKSSPEVSSISQEALHLTGKATELFIQALARFSHQQSDDKSALSYRDLAEVVNSEETLQFLHDIVPRKIKAKEYLKSLRDADASEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T7F0</accession>
    <name>A0A433T7F0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_014706</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="RQTK01000574">
        <property type="protein sequence ID" value="RUS77522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A433T7F0"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17065">
        <property type="entry name" value="Ubl_UBP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056850">
        <property type="entry name" value="ARM_UBP34_24_USP9X_Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021905">
        <property type="entry name" value="DUF3517"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055176">
        <property type="entry name" value="UBP24/USP9X/USP9Y_UBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047061">
        <property type="entry name" value="UBP24_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF943">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE PUF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25010">
        <property type="entry name" value="ARM_UBP24_USP9X-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12030">
        <property type="entry name" value="DUF3517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22900">
        <property type="entry name" value="UCH_UBL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBA" evidence="10">
        <location>
            <begin position="5"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="11">
        <location>
            <begin position="1697"/>
            <end position="2089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="993"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1362"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2580"/>
            <end position="2599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2623"/>
            <end position="2709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="993"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1370"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2580"/>
            <end position="2589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="2623"/>
            <end position="2649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="2664"/>
            <end position="2682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS77522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="2709" mass="302752" checksum="DF9AACD8642C983E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T7G0</accession>
    <name>A0A433T7G0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Plectin/eS10 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_014740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000576">
        <property type="protein sequence ID" value="RUS77493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T7G0"/>
    <dbReference type="STRING" id="188477.A0A433T7G0"/>
    <dbReference type="OrthoDB" id="5211809at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000025">
        <property type="entry name" value="40S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005326">
        <property type="entry name" value="Plectin_eS10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037447">
        <property type="entry name" value="Ribosomal_eS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03501">
        <property type="entry name" value="S10_plectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Plectin/eS10 N-terminal" evidence="7">
        <location>
            <begin position="3"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="90"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS77493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="163" mass="18121" checksum="B128B019EDEC0D40" modified="2019-05-08" version="1">MLIPKKNRVQIYEYLFKEGVLVAKSDKALPKHPHIEVPNLEVIKAMQSLTSRGYVREQFAWGYHYYYLTNEGIQYLRDFLHLPAEIVPSTLKRATRTEAPKPRFKGSEGAPRAGGGATDRQEYRKAGPPGTDKKSDVGPGSQDLEFRGGYGRGRGGFGGPPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TC35</accession>
    <name>A0A433TC35_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_013175</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000473">
        <property type="protein sequence ID" value="RUS79070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A433TC35"/>
    <dbReference type="OrthoDB" id="6275838at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000015">
        <property type="entry name" value="neurexin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF89">
        <property type="entry name" value="NEUREXIN 1, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1285"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="10">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="185"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="10">
        <location>
            <begin position="228"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="10">
        <location>
            <begin position="424"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="10">
        <location>
            <begin position="744"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="925"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="10">
        <location>
            <begin position="966"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1181"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1329"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1231"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1248"/>
            <end position="1260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS79070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1360" mass="149423" checksum="0317ADEA6393C8F6" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TF40</accession>
    <name>A0A433TF40_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_012044</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000406">
        <property type="protein sequence ID" value="RUS80187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TF40"/>
    <dbReference type="STRING" id="188477.A0A433TF40"/>
    <dbReference type="OrthoDB" id="2014092at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF515">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS80187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="280" mass="31339" checksum="589E1A746C7529D2" modified="2019-05-08" version="1">MACFTSRTTFVNPVLKYTLFFFNFLFWLAGLTMLAIGIWAHTEKEMFSFEYVKSVFDFLTDVSILCIITGCLIFLLGFCGCLGALRENTCLIKTYCFTLCALFLGQAAGAVYIFFKSSEFKDVFIKTLKEELVPLYTEKADKKTLVDWVQSQMECCGMSTDGFKDWNNNEYYNCTKLNKSPLACAVPHSCCIKQDTVYNGVPNILCGANALNEKVRGATDNIYMVGCVSAVMQVVQLNLPIVGGVIIGLAVPQILGIVLSRTLDGQITDQLDRWKRMNLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TIA0</accession>
    <name>A0A433TIA0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MAP kinase-activating death domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_010917</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MADD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000344">
        <property type="protein sequence ID" value="RUS81310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TIA0"/>
    <dbReference type="STRING" id="188477.A0A433TIA0"/>
    <dbReference type="OrthoDB" id="6282239at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="MAP kinase-activating death domain protein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="cDENN_dom"/>
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        <property type="entry name" value="dDENN_dom"/>
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        <property type="entry name" value="DENN_C"/>
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        <property type="entry name" value="MADD"/>
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        <property type="entry name" value="Tripartite_DENN"/>
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    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13008:SF7">
        <property type="entry name" value="MAP KINASE-ACTIVATING DEATH DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13008">
        <property type="entry name" value="MAP-KINASE ACTIVATING DEATH DOMAIN PROTEIN MADD /DENN/AEX-3 C.ELEGANS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
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        <location>
            <begin position="15"/>
            <end position="538"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="10">
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            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="590"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="662"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="829"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="875"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1019"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="604"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="672"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="688"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="720"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="757"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="881"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1065"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1087"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS81310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1117" mass="122410" checksum="EF2DE3D6ED3E750E" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TKT0</accession>
    <name>A0A433TKT0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TNFR-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_010043</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000298">
        <property type="protein sequence ID" value="RUS82203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="188477.A0A433TKT0"/>
    <dbReference type="OrthoDB" id="6157299at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR052459">
        <property type="entry name" value="TNFRSF_decoy_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23097:SF181">
        <property type="entry name" value="CASPASE-8-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23097">
        <property type="entry name" value="TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS82203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="36607" checksum="A3F004A470DAA210" modified="2019-05-08" version="1" fragment="single">MWSLPPWSLGFTMEFPFTRLIRVQVMSKKTSDKMCPKSITDSCPAGHLLTKCDTGDGYQCQECPEDMFQPNENWLPDNCRYRKRCKRPWMKYKHRGSITDDAECTCMDGYHLNGEDQRFCIENTPCPKGTEPGQYGNCVDCLPKGMYSDTEGTTKRCKPLTNCEKQQRCTVQPSDGKMDNVCGPIVKDTESCEALRPPSTSLSAIQITAIVAGGVVLLLVLLAIFFVSRRNALRRKGRRGLKSADREKGAGRPLSDGEMEELRLTLLKECDRDPALCKKVLQTSRSFIEERIDRQIWTLAQELYRTYPKPGRFEQIVQKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TKX7</accession>
    <name>A0A433TKX7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_010018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000297">
        <property type="protein sequence ID" value="RUS82204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TKX7"/>
    <dbReference type="OrthoDB" id="6157025at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="503"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS82204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="586" mass="63891" checksum="713BA7A0DE4C87AB" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TLF6</accession>
    <name>A0A433TLF6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_009821</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000287">
        <property type="protein sequence ID" value="RUS82433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TLF6"/>
    <dbReference type="OrthoDB" id="6148855at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008506">
        <property type="term" value="F:sucrose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF35">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 45 MEMBER 3 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="312"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="326"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS82433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="451" mass="49157" checksum="2C1323366F664377" modified="2019-05-08" version="1">MTVPDKVRLAGSMMLLWQLSITSEMIGLEATIVMEVILMIANLQTLGVPVRYCSLPGTVAAIVSFFLIPCLAFVLDKWAKSKQSKAKILAFTTAIQILGSSLVLLANGLNLRMKSVLKSNDVANLTDSLLLDNMFAFNETSLADRKNLLGDVFGSITPYTVNTLQSDSVDGALPFYTYIAMIGYTLIDCGYDSSNCFLKTFVLHCAPVEYHRSLIIKLTMVSSIGGGLISILGSLDLGQIFTAGAGLDSSSAMTCLMAALTTALLLSGTLSTFACGFWWKPPLHRNESEYGTKCDEQAALVPVRDIKLKSRGNGLVKSPDRAMEPKQQSYSHSGTRISSPRDTKRDQSVDIRLDEPNHSGIQGYMQRQQKQLLINASAFFLFSSNYAFDMYLTNFSGTRVFGGDPKAPSDSQSYQRYMDGLAAGSRGVVIQYIVFAVTNCLHEQSLAAFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TLW4</accession>
    <name>A0A433TLW4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_009646</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000280">
        <property type="protein sequence ID" value="RUS82572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TLW4"/>
    <dbReference type="STRING" id="188477.A0A433TLW4"/>
    <dbReference type="OrthoDB" id="6281784at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="47"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS82572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="366" mass="40725" checksum="70F3795F8473BED6" modified="2019-05-08" version="1" fragment="single">ATMNELNLKVNISYGDSSLSEESANNLSLFVLWGVLLPLVAAAGLLGNVLTMLVLWRREMNSTTILYMRGLVITDTGILLGSVLTLTPIAYFSNVIYPVIYTPGFYFVMTLQQINVWITVSVSVERYIAICHPFRAARLISKKKTLAAMLGITLFSVLYNLPHLFATEAVSCPAAPGGQSGGCLQVTTTGFGQTEFYLSYREYMYLIIIYVLPFIALLILNSFLIRELMTMQRRATSTGSKEENEANMSLVLILIVIVFIFCQTPGLLSQFEVVPVSVFPTYLGVSNLLFATNSAVNFLIYTAFGKRFRRVLLRLFRHLYTGKGSKRRRASSASSCHAALTQYSLSNANDAVEMERLPPQYDTLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TNJ4</accession>
    <name>A0A433TNJ4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_009094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000256">
        <property type="protein sequence ID" value="RUS83147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TNJ4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS83147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="213" mass="24011" checksum="714497EED00CF0E2" modified="2019-05-08" version="1" fragment="single">MERMSLPSEPGETSENSPPAEPEETPEDSPAEPPQGRRALLASLLDVDHAFSWLQVFSYYFYNVVPFVVFVPTRFYRTTIAAIGLVAIGHIGLNIRNFFANKKKIDDRKARLGMNLSDLKQSLTIFEEEEDQSLTDLSFDKLSVNLKDGSLDQNKLLVEFHRRALKSKKFNFVTEYIIKSIKTESAAEKKGKTKSTQALSGIPVSISEAYQMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TP72</accession>
    <name>A0A433TP72_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_008909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000248">
        <property type="protein sequence ID" value="RUS83331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TP72"/>
    <dbReference type="OrthoDB" id="6142946at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="594"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS83331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="617" mass="68824" checksum="5DA2EFD3C80A5D3A" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TQ91</accession>
    <name>A0A433TQ91_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_008485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000232">
        <property type="protein sequence ID" value="RUS83734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TQ91"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS83734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="17511" checksum="AA096D3F3DB5507B" modified="2019-05-08" version="1">MSNLMLFFLEYCLIFLCWLLWSFLFLPLYYIFFVRFSFDPFFIIFTWSVRLVYVFLIYVRFCFYTRLFILVCCPSFLFLLLWSCLFYPLSYTYCMDFSLFPCMPTIFRVFFRLLRVILIFSQISFYPRLFFLVYCLSFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TRR5</accession>
    <name>A0A433TRR5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylinositol N-acetylglucosaminyltransferase subunit H conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_007975</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIGH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000211">
        <property type="protein sequence ID" value="RUS84282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TRR5"/>
    <dbReference type="OrthoDB" id="6256716at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044215">
        <property type="entry name" value="PIG-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019328">
        <property type="entry name" value="PIGH-H_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15231">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15231:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10181">
        <property type="entry name" value="PIG-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019063875" description="Phosphatidylinositol N-acetylglucosaminyltransferase subunit H conserved domain-containing protein" evidence="3">
        <location>
            <begin position="17"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidylinositol N-acetylglucosaminyltransferase subunit H conserved" evidence="4">
        <location>
            <begin position="27"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS84282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="94" mass="10687" checksum="5FFFB8E926F4A51B" modified="2019-05-08" version="1">MIHILVLFTHCGPGCAYMASIFDIRESVLILPSLGLQVKTLYYLGHVKTHFIDASHIEDIIINEAITMHSWPPLSSLKDVYRAAQEKLIKPKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TTN4</accession>
    <name>A0A433TTN4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vitellogenin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_007329</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000189">
        <property type="protein sequence ID" value="RUS84919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TTN4"/>
    <dbReference type="STRING" id="188477.A0A433TTN4"/>
    <dbReference type="OrthoDB" id="6484170at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.230.10">
        <property type="entry name" value="Lipovitellin, beta-sheet shell regions, chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.20">
        <property type="entry name" value="Vitellinogen, superhelical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015819">
        <property type="entry name" value="Lipid_transp_b-sht_shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011030">
        <property type="entry name" value="Lipovitellin_superhlx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015816">
        <property type="entry name" value="Vitellinogen_b-sht_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050733">
        <property type="entry name" value="Vitellogenin/Apolipophorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001747">
        <property type="entry name" value="Vitellogenin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345:SF15">
        <property type="entry name" value="VITELLOGENIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345">
        <property type="entry name" value="VITELLOGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01347">
        <property type="entry name" value="Vitellogenin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00638">
        <property type="entry name" value="LPD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56968">
        <property type="entry name" value="Lipovitellin-phosvitin complex, beta-sheet shell regions"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48431">
        <property type="entry name" value="Lipovitellin-phosvitin complex, superhelical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51211">
        <property type="entry name" value="VITELLOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0758">Storage protein</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019206582" description="Vitellogenin domain-containing protein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="Vitellogenin" evidence="7">
        <location>
            <begin position="47"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS84919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="657" mass="74637" checksum="368C7A1BB007C15C" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TTP8</accession>
    <name>A0A433TTP8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_007291</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000188">
        <property type="protein sequence ID" value="RUS84929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TTP8"/>
    <dbReference type="STRING" id="188477.A0A433TTP8"/>
    <dbReference type="OrthoDB" id="2261376at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="66"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS84929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="203" mass="21857" checksum="1CBC4E2D00656109" modified="2019-05-08" version="1" fragment="single">MTDTEKLISTLGGRGRFQNTIHLLAGFGGYVPLCFNHVIMAFHGSKIPHTCRAGADIEIGSNSSSSSGQAYVTNVTHGQCLTTVAYSDGQEKVLACSAGQWEYSPHYGETNIVSQFDLVCSAEYLTSMATTIYFTGVMVGGLVFGDLADRFGRRLSMMVTMFSALVVSLVSAFSVNYAMFVCLRFLLGVLQQVGGPLLVLCLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TV99</accession>
    <name>A0A433TV99_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_006795</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000169">
        <property type="protein sequence ID" value="RUS85462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TV99"/>
    <dbReference type="STRING" id="188477.A0A433TV99"/>
    <dbReference type="OrthoDB" id="6260400at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11410">
        <property type="entry name" value="bHLH_O_HES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050370">
        <property type="entry name" value="HES_HEY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003650">
        <property type="entry name" value="Orange_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10985">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07527">
        <property type="entry name" value="Hairy_orange"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00511">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158457">
        <property type="entry name" value="Orange domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51054">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="28"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Orange" evidence="7">
        <location>
            <begin position="100"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="180"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="311"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="604"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="844"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="899"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1024"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="311"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="609"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="845"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="901"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="924"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1025"/>
            <end position="1045"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS85462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1239" mass="136915" checksum="309AEA85EF953F93" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TWK3</accession>
    <name>A0A433TWK3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_006250</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000154">
        <property type="protein sequence ID" value="RUS85980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TWK3"/>
    <dbReference type="STRING" id="188477.A0A433TWK3"/>
    <dbReference type="OrthoDB" id="198857at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002144">
        <property type="term" value="C:cytosolic tRNA wobble base thiouridylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="CTU1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000132">
        <property type="entry name" value="Cytoplasmic tRNA 2-thiolation protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056369">
        <property type="entry name" value="CTU1-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054306">
        <property type="entry name" value="TtuA-like_LIM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020554">
        <property type="entry name" value="UPF0021_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807">
        <property type="entry name" value="ATPASES OF THE PP SUPERFAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807:SF12">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22082">
        <property type="entry name" value="TtuA_LIM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01263">
        <property type="entry name" value="UPF0021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="2-thiouridine synthetase TtuA-like N-terminal LIM" evidence="9">
        <location>
            <begin position="4"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="8">
        <location>
            <begin position="52"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="55"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00060195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR004976-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS85980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="267" mass="29959" checksum="DC884B7E46251C38" modified="2019-05-08" version="1" fragment="single">MPRKCGNCSNNAVLKRPKTGDALCKDCFYWAFEEEIHQTIVDASLFSPGDTVAIGASGGKDSTVLAHTMKVLNDRHGYGLNLILLSVDEGITGYRDDSLETVKRNQQQYDLPLTIVSYEELYGWTMDAIVEQIGLKNNCTFCGVFRRQALDRGALKLGVTKIVTGHNADDIAETVIMNVLRGDIARLRRCTAITTGADGYLPRCKPFKYAYEKEIVMYAYFKQLDYFSTECIYSPNAYRGYARTYIKDLEKIRPSAIIDIIHSGESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2024-05-29" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U0I2</accession>
    <name>A0A433U0I2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_004906</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000113">
        <property type="protein sequence ID" value="RUS87364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U0I2"/>
    <dbReference type="STRING" id="188477.A0A433U0I2"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS87364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="141" mass="15949" checksum="ECB5443CFF03D8EB" modified="2019-05-08" version="1" fragment="single">CFHTHQSLLSYSPILAFTLINPCFHTHQSLLSHSPILAFTLTNPCFHTHQSLLSYSPILAFTLINPCFHTHQSLPSYSPILAFILINLCFHTHQSLLSYSPILAFILTNPCFHTHQSLRSHSSIFAFTLTNPCVHTHQSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U3U2</accession>
    <name>A0A433U3U2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PKD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_003750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000081">
        <property type="protein sequence ID" value="RUS88492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U3U2"/>
    <dbReference type="STRING" id="188477.A0A433U3U2"/>
    <dbReference type="OrthoDB" id="10050421at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00146">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00801">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="PKD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKD" evidence="1">
        <location>
            <begin position="35"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS88492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="225" mass="24763" checksum="1D3FB216D685B3E0" modified="2019-05-08" version="1">MKLLVKYALALTKVRLKEFSRASGTTSNIALSLTSGSDYSCTWNFGDGTVTENTDEAELIALSFTKTHLYLSAGSYTITVTCSNNVSSQVATTVARIQQTITGLRMTSEGADKGDDFYIRWEVSAGTEITFALTFDGVPITTHTEYETKKWQSNLQAGRPVSAIPLTLTASNLISCRPPRVRHPPDLDCVQPDQLGVPERHLQDLDRHCQPDLHLADAECQQVCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U405</accession>
    <name>A0A433U405_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_003662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000079">
        <property type="protein sequence ID" value="RUS88562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U405"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS88562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="133" mass="15709" checksum="C9D6189AB5482258" modified="2019-05-08" version="1">MELNFLKEEQKSTCDQKSRKPFKNSLKARTSLQAQNSHLGVICNKFLSGYFQQLKLIFALWLKNMPARFKEIGKEKWKVFLLKYNSQFWASSSHTKFESQRNTLSTPPGYDMSWKSGHLLYEHYLFGRVLFMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U5K7</accession>
    <name>A0A433U5K7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_003156</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000066">
        <property type="protein sequence ID" value="RUS89093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U5K7"/>
    <dbReference type="STRING" id="188477.A0A433U5K7"/>
    <dbReference type="OrthoDB" id="1747252at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS89093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="39794" checksum="0B57BA4E6126F174" modified="2019-05-08" version="1">MAASISKSLMLKLNLHQVYQTRALHCLTSWLPQTSLSTNFTQIRHRNSNHRVKDATVQATKENKFISKKSKKKALTTLAATVEKSTILADKPVDDVWVRKFYPPPRFSIEEALQRHQAFAQPAMLNNLKGLIYLDMRLDFSTKKKTKFLGNIRASVRLPHEFPYGSPPNILVFCKSEENVNLAMSLGAKQAGTPQDIIKQINEGVLNPKDFEHVLSTSDCSNEILPARSHFRDRFPQKAKGSLGPDLKEMWDVFYYGYCYESTKLSDAIGHVQVPLGLLEQPVEDLVENFQTYISHICQHRPVALGPFIQSISVLAPPSPEEFIVKVEDYVPGYKSEDVDSDAEDEAEAMGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U8I4</accession>
    <name>A0A433U8I4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sn-1-specific diacylglycerol lipase</fullName>
            <ecNumber evidence="14">3.1.1.116</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EGW08_002150</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">EC2010</strain>
            <tissue evidence="17">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="14"/>
    <dbReference type="EMBL" id="RQTK01000040">
        <property type="protein sequence ID" value="RUS90108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U8I4"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046340">
        <property type="term" value="P:diacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052214">
        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF8">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="16">
        <location>
            <begin position="413"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RUS90108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="674" mass="76186" checksum="B0B8207B74FC318E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UAT7</accession>
    <name>A0A433UAT7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_001305</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000022">
        <property type="protein sequence ID" value="RUS90908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UAT7"/>
    <dbReference type="STRING" id="188477.A0A433UAT7"/>
    <dbReference type="OrthoDB" id="9046662at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15203">
        <property type="entry name" value="7tmA_NPYR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235:SF12">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235">
        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="73"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS90908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="420" mass="47139" checksum="025D41EA221FA282" modified="2019-05-08" version="1">MSELNLEAGMPPYSVDSNGSMNESSGSGGGLPLSDDILRQIIDASMNTRHFDPVTETVLVLCYAVLITFGAMGNGLVIFVVLRKPTMRTPRNIFIINLAISDFTLCLFTQPLNLYLLLSQKWSLGEFMCKFVTMAQGTNLFVSTISITAIALDRFQVIVYPTKDSMKKLGAAIALISIWLISFLIASPTLLFSVVHKNKVIEEISNIYRYICMEDVSMEVEKRAYSVAQMVVQYVFPFFILSVAHLRICNKLRYRMVAQNAPSAASTSFQRKKNERRSRRKRKTNMLLAGIALVFALSWLPLNIFNLLTDFKGSYFRGRIDMRLAYVICHMLVLCSGCLNPVLYGWLNDNFRTEFVNILCCPCCKIGHNRLKRFFCCSRQASGVPAITLTKVGNGQSMILDEGIGNGKSESLTLQYQTQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z2I8</accession>
    <name>A0A3S0Z2I8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Small nuclear ribonucleoprotein Sm D1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">snRNP core protein D1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_022887</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the snRNP core protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001716">
        <property type="protein sequence ID" value="RUS69349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z2I8"/>
    <dbReference type="STRING" id="188477.A0A3S0Z2I8"/>
    <dbReference type="OrthoDB" id="9626941at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01724">
        <property type="entry name" value="Sm_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000016">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034102">
        <property type="entry name" value="Sm_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="2"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="82"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="116"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS69349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="131" mass="14122" checksum="8592C28C19E30AA1" modified="2019-04-10" version="1">MKLVRFLMKLSHETVTIELKNGTQVHGTVTGVDVSMNTHLKAVKMTVKNKEPQQLDSLSIRGNNIRYYILPDSLPLDTLLIDDAPRSKARGKRDGGKAPMGRGRGRGGPRGRGRGGPRGGGGRGGPRGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z3R3</accession>
    <name>A0A3S0Z3R3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_023565</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="RQTK01002118">
        <property type="protein sequence ID" value="RUS68673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z3R3"/>
    <dbReference type="STRING" id="188477.A0A3S0Z3R3"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF41">
        <property type="entry name" value="CHITIN SYNTHASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS68673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="322" mass="35719" checksum="395654235C0ABC9D" modified="2019-04-10" version="1" fragment="single">KVLSLCACDRSLGAVCGRSVPKGSAKPIVWYQKFEYAKDFWLVKSSQNIIGSVTCCPGCFSLYRAEALSGIVDAFSQPAKSAFQCLVMDHGEDRWLCTLLMRQGWRLAYSCSARNSTHCPETVGEFLRQRRRWVLSELFNMADIFLSVRRLVRENSSFSVAFLLSLFTTLLWVIVSPATTLLCVCAGMSVLCSVPLCASLPTAAAIFAGYCAVCWFGSQRMQKMASLGLTLIMAVAVVTLSVFFLIYITRKIHDGIAVTFRPYILVILMSGYAIYAALLHHREIPSLIYGLAYALLFPAIFVALPVYALSNMLDQSWGTRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z6A4</accession>
    <name>A0A3S0Z6A4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_020630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001188">
        <property type="protein sequence ID" value="RUS71603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z6A4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS71603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="202" mass="23474" checksum="984626390C519889" modified="2019-04-10" version="1">MDKLRKLQAEKEKEEREAKLQAEKEEREAKLHAEKEEREAKLHAEKEEREAKLQAEKELKMEEMRTQLELARIQAQAIPVISETASAMEHCMAVDAPVPRLFRRCDVGPKILSICAVIWSIPCFLDVSYSDEDDNCYLLKLPDRQSLPGLVRLYFLIAADVACIVFFFTLQSRYDVGPKMYCQADHFLTLTQHHQQQTCFKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZER9</accession>
    <name>A0A3S0ZER9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_014998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000596">
        <property type="protein sequence ID" value="RUS77245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZER9"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS77245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="137" mass="17937" checksum="1C55F07B00B1182E" modified="2019-04-10" version="1">MTKTLTEQRLRSHRKKRKKRRKQLRMRRRENSKRMQRRMLARKRRSKRKRKKRRSKRRRKKRRSERERKKKNKREKKKRRQRERGRKQRKRQERRKKLMHNKRKSSQKRYLWRTKEQMLKMNLMPKLLQDLKKATLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZHJ2</accession>
    <name>A0A3S0ZHJ2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_014462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000553">
        <property type="protein sequence ID" value="RUS77777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZHJ2"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS77777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="260" mass="27888" checksum="2B7DD215AEB459F2" modified="2019-04-10" version="1" fragment="single">TKCLYLGVTGNKCLYLGVKGTKYMYLGVTGTKCLYLGVIETKCLYLGGTKCLYLGETKCLYLGVTGTKCLYLGVTGTKCLYLGVTETKCLYLGVTETKCLLYLGGTKCLYLGVTGTKCLYLGFKETKCLYLGATETKCLYLGVTGTKCLYLGVIGTKCLYLGVTGTKCLYPCGAGTKFLCATGTKCLYLGVTGTKCLYLGAIETKCLYLGAIETKCLYLGAIETKCLCLGVTGTKCLYLGVTGTKCLYLGATETKYLYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZKL9</accession>
    <name>A0A3S0ZKL9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_022645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001626">
        <property type="protein sequence ID" value="RUS69596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZKL9"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS69596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="86" mass="9434" checksum="857AC74F38781D52" modified="2019-04-10" version="1" fragment="single">TISLRLPDSITKAHTCRHNVKVWHVLLHGPPQAEHDQEAAIKRGGECERYEHLPLNVPGDTAYGDGADCAHCAETDEDGTNVVQTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZPC9</accession>
    <name>A0A3S0ZPC9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_008466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000231">
        <property type="protein sequence ID" value="RUS83760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZPC9"/>
    <dbReference type="OrthoDB" id="6145298at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018604233" description="Secreted protein" evidence="2">
        <location>
            <begin position="33"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS83760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="17918" checksum="D243E5F2A98BFA24" modified="2019-04-10" version="1">MPYHVSAVYQSAPALLVPVLLLLVVCCRPSLALCETRCEQSVPDLARLRGVWEQSFRRMGGRNISFNHFLLTLVREPTEGRGGSRRIRDFVLDVVGTFEECMVSCEHQFSKRSSDRHRPRPLRPRLRVKTARSGSKSGSRSKLKSRSILVLRLRPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZRI2</accession>
    <name>A0A3S0ZRI2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI transamidase component PIG-T</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_007177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000184">
        <property type="protein sequence ID" value="RUS85040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZRI2"/>
    <dbReference type="STRING" id="188477.A0A3S0ZRI2"/>
    <dbReference type="OrthoDB" id="331263at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007245">
        <property type="entry name" value="PIG-T"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959:SF11">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04113">
        <property type="entry name" value="Gpi16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018643214" description="GPI transamidase component PIG-T" evidence="2">
        <location>
            <begin position="25"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS85040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="612" mass="69251" checksum="21D5288201A7DBAC" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZT87</accession>
    <name>A0A3S0ZT87_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_006034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000147">
        <property type="protein sequence ID" value="RUS86188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZT87"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS86188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="106" mass="11242" checksum="193A6E89F5CB7032" modified="2019-04-10" version="1" fragment="single">GPPVPVFRLLWAAAHAGDYRGPVRVRQENLAKSKSRYKALEEKKQAEASCHCDSLEGGSHKGCKVVRPHRENWTVKYINLSCGGGSGADSTFSSGSSSSSSSSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZVW5</accession>
    <name>A0A3S0ZVW5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_004958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000115">
        <property type="protein sequence ID" value="RUS87278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZVW5"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050972">
        <property type="entry name" value="SDr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34403:SF14">
        <property type="entry name" value="OS05G0225800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34403">
        <property type="entry name" value="TOL-PAL SYSTEM PROTEIN TOLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS87278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="262" mass="29023" checksum="2E204EA2D49C3CDD" modified="2019-04-10" version="1">MIAERQAIQTDLAREPKDAETRHDLASQETRNLHKSHYRRCFQGLLAAQNTTLIFIDSNLAAQKNVYEIPGGNHFLRNSGGREAWERTNQGDIGSGWLRFRQLKQLRRINHHPIFLRSEAWPITLSFINTKLTKELGSSIAQDTALDPSPYPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZXP7</accession>
    <name>A0A3S0ZXP7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">EGW08_006586</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">EC2010</strain>
            <tissue evidence="23">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the polycystin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000163">
        <property type="protein sequence ID" value="RUS85640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZXP7"/>
    <dbReference type="STRING" id="188477.A0A3S0ZXP7"/>
    <dbReference type="OrthoDB" id="444119at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050982">
        <property type="term" value="P:detection of mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000055">
        <property type="entry name" value="Polycystic kidney disease 2-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013122">
        <property type="entry name" value="PKD1_2_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003915">
        <property type="entry name" value="PKD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051223">
        <property type="entry name" value="Polycystin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046791">
        <property type="entry name" value="Polycystin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877:SF183">
        <property type="entry name" value="AT14535P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877">
        <property type="entry name" value="POLYCYSTIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08016">
        <property type="entry name" value="PKD_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20519">
        <property type="entry name" value="Polycystin_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01433">
        <property type="entry name" value="POLYCYSTIN2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 18" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="18" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="17" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16 18" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="489"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="22">
        <location>
            <begin position="585"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="618"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="618"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="635"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="598"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="600"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="609"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR603915-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR603915-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="RUS85640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="694" mass="80001" checksum="8BFE80D61276981C" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZZM1</accession>
    <name>A0A3S0ZZM1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_005285</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000123">
        <property type="protein sequence ID" value="RUS86960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZZM1"/>
    <dbReference type="STRING" id="188477.A0A3S0ZZM1"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000016">
        <property type="entry name" value="Forkhead box protein I1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF388">
        <property type="entry name" value="FORK HEAD DOMAIN-CONTAINING PROTEIN L1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="7">
        <location>
            <begin position="211"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Fork-head" evidence="7">
        <location>
            <begin position="269"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="211"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="269"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS86960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="375" mass="41871" checksum="8A4DA5893557D432" modified="2019-04-10" version="1" fragment="single">MALREPEVSALAIICSTAIFLEPATRPWDLEGSGTLVFIDEKSSAHPAITTEDITSESLYLQYQESYQRGRYSQFPGTDSHRLSPGFLAGTAGFSVSNIDSACTSGVRATSLGPHATHPHTMLDMQGLQSAYPGSAVGGMGSIPNIMGGTPGLGLMPSFYGDQNYYRHSSYGMAMGGMSMYGDQYGAMGRPSPYGPYGGHMPHHPVKEMVKPPYSYIALIAMAIQTAPGQKITLNGIYQYIMDKFPFYRENKTKYGGHMPHHPVKEMVKPPYSYIALIAMAIQTAPGQKITLNGIYQYIMDKFPFYRENKQGWQNSIRHNLSLNECFVKVPRDDKKPGKGSYWMLHPESHNMFDNGSYLRRRRRFKRSPAEKERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A224</accession>
    <name>A0A3S1A224_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_011526</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000377">
        <property type="protein sequence ID" value="RUS80703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A224"/>
    <dbReference type="STRING" id="188477.A0A3S1A224"/>
    <dbReference type="OrthoDB" id="10051649at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15039">
        <property type="entry name" value="7tmB3_Methuselah-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053231">
        <property type="entry name" value="GPCR_LN-TM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902:SF1">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="659"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="695"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="734"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="774"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="816"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="864"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="891"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="658"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="935"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="939"/>
            <end position="964"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS80703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="964" mass="108039" checksum="21C08708DF76CA1F" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A5Z1</accession>
    <name>A0A3S1A5Z1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_008653</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000238">
        <property type="protein sequence ID" value="RUS83599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A5Z1"/>
    <dbReference type="STRING" id="188477.A0A3S1A5Z1"/>
    <dbReference type="OrthoDB" id="6156027at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="7">
        <location>
            <begin position="51"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="144"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS83599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="181" mass="20633" checksum="0786364FE610F37A" modified="2019-04-10" version="1">MHLSLVGGGEDEEITELNTRVMAVNIVLTPTFEQAGGKRGDQNLVRTRNLLIRIRRLYLVRQLSWKLKPFTLTVAAARLYRCKVWIQNSRRQDLMGLSADVIRKKRVVFCSEHFEENQFNCPLELSSSSRRTLKWNAVPTLFDIPNPPPKATPKRKHTIRAAPEVPSKKTKSNISQASQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A8X1</accession>
    <name>A0A3S1A8X1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA damage-inducible transcript 4-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_006598</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DDIT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000163">
        <property type="protein sequence ID" value="RUS85652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A8X1"/>
    <dbReference type="STRING" id="188477.A0A3S1A8X1"/>
    <dbReference type="OrthoDB" id="10018535at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032006">
        <property type="term" value="P:regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.40">
        <property type="entry name" value="RTP801-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012918">
        <property type="entry name" value="RTP801-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038281">
        <property type="entry name" value="RTP801-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12478">
        <property type="entry name" value="DNA-DAMAGE-INDUCIBLE TRANSCRIPT 4 PROTEIN DDIT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12478:SF16">
        <property type="entry name" value="PROTEIN CHARYBDE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07809">
        <property type="entry name" value="RTP801_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS85652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="24308" checksum="5D2FBBDE4ED7BCC2" modified="2019-04-10" version="1">MRLALRIKHLMKSFLEGNKSDCDYSPIMEPDFEHGRPNSFSKLEGSDANMNTYGSASFSPNPAAPGDLQLDLCMGEQLKVEDAIRAACERELNCRVVFPPELLARVAGDILRMSVAEPCGVRGCAIILCLQEKDRCHKLATVFGGSFTPPTFEIHVTLREDTRSWKAFQKVFLTIKNCLLNSSQWKSSPRILHPAYQLEKRRLYRGVSSGVEGNGYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A9I2</accession>
    <name>A0A3S1A9I2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mannose-1-phosphate guanylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_006177</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="3"/>
    <dbReference type="EMBL" id="RQTK01000151">
        <property type="protein sequence ID" value="RUS86084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A9I2"/>
    <dbReference type="STRING" id="188477.A0A3S1A9I2"/>
    <dbReference type="OrthoDB" id="1733332at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06425">
        <property type="entry name" value="M1P_guanylylT_B_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000018">
        <property type="entry name" value="Mannose-1-phosphate guanyltransferase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000013">
        <property type="entry name" value="mannose-1-phosphate guanyltransferase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045233">
        <property type="entry name" value="GMPPB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="9">
        <location>
            <begin position="2"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="10">
        <location>
            <begin position="250"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS86084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="360" mass="39982" checksum="50A61FB7FB4C1732" modified="2019-04-10" version="1">MKALILVGGYGTRLRPLTLSIPKPLVEFGNKPMLFHQLEALVDAGVSHIVLAVSYRAEQMEKELENAQKELGIKISISLEEEPLGTAGPLALARDILCSDDEPFFVLNSDIICDFPFKDMLQFHKNHGKEGTIVVTKVDEPSKYGVVVYSPENGAIQRFVEKPLEYVSNKINAGMYIFNPSMLRRIKLQPTSIEKEVFPFMADDGQLFAMELQGFWMDVGQPKDFLTGMCLYLTSLKHRKPELLHQGPGIVGNVLIDPTAKIGNNCRIGPNVTIGPKAVIEDGVCIKRCTVLSEAHIKSHSWLESCIVGWKCVVGNWVRMENVSVLGEDVIVKDELYINGGRILPHKSIGESVPDPKIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AB00</accession>
    <name>A0A3S1AB00_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_005129</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the prohibitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000119">
        <property type="protein sequence ID" value="RUS87129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AB00"/>
    <dbReference type="STRING" id="188477.A0A3S1AB00"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF1">
        <property type="entry name" value="PROHIBITIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="7">
        <location>
            <begin position="40"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS87129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="300" mass="33249" checksum="20DFB225F128984A" modified="2019-04-10" version="1">MDPKKAADLAGRLKKAGPKGVGAGLGIFALAGGIYGLTQSVYTVEGGHRAIIFSRISGVKPDIYVEGLHFRVPWFQYPIIYDIRSRPRKLSSPTGSKDLQMVNISLRVLSRPNAQALPQMYRQLGTDFDDRVLPSITNEVLKSVVAKFNASQLITQRQQVSLLIRRELTQRARDFNIILDDVSITDLSFGKEYTSAVESKQVAQQDAQRAQFLVEKAIQEKQQKVVQAEGEAEAARLIGEAMSLNPGYLKLRKIRAAQNIARTIAQSQNRVYLNASSLMMNIGDESFDIAADTLVGKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AW72</accession>
    <name>A0A3S1AW72_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EGW08_023324</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">EC2010</strain>
            <tissue evidence="16">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="RQTK01001929">
        <property type="protein sequence ID" value="RUS68916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AW72"/>
    <dbReference type="STRING" id="188477.A0A3S1AW72"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17951">
        <property type="entry name" value="DEADc_DDX41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000657">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DDX41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044113">
        <property type="entry name" value="DEADc_DDX41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="211"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="242"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="211"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RUS68916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="522" mass="58765" checksum="9AEA48C9C2E60366" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AWR7</accession>
    <name>A0A3S1AWR7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_016703</name>
        <name evidence="2" type="ORF">EGW08_021961</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001446">
        <property type="protein sequence ID" value="RUS70284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RQTK01000732">
        <property type="protein sequence ID" value="RUS75535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AWR7"/>
    <dbReference type="OrthoDB" id="6214555at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS70284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS75535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="351" mass="39878" checksum="EF81CC3EC55053B5" modified="2019-04-10" version="1">MFNVSDIGQGNDVSAEQLEAQIMMFHKNHPNEHIMAVEGVIDDGPTNNINSILKYSNPLYFKTLLIPILASWPLTFVIFIIYAYNTMRGVGYISRPPKVTAKMIFLPLLLVPMIVDNYYDLITKASVSEYDSDILLLIIIAMALFVVISIAYITFYCFQLVQNNNYIKKSGYTRLSMVDSISEDAQENDGNDDERGGAELNVNIKLPSRIKNPNRWDIIVNEYMTMNGVYGLMIYNILLLIIYVMRYLTNKDTNCIRETDVAIISAVLGALLIPNIIFDWLTFKIPQAASLVMHYYLISVFALNFTLDFYDQLEYCEEITLGITFAATFLTAGKFKLFNDIGGSVTTYKMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AZZ0</accession>
    <name>A0A3S1AZZ0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibrinogen C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_019518</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001027">
        <property type="protein sequence ID" value="RUS72720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AZZ0"/>
    <dbReference type="STRING" id="188477.A0A3S1AZZ0"/>
    <dbReference type="OrthoDB" id="7735550at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018576330" description="Fibrinogen C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="3">
        <location>
            <begin position="88"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS72720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="216" mass="24224" checksum="5B4B6CBDAD86B690" modified="2019-04-10" version="1" fragment="single">MGLRDLFTVARLVTLLVMASATTGLVQTPGLSVPSANDSSSTSTILLKLETMELKLDTLEAIRNKIDRLDAKVETLNNAVLEKVKSAFTDLFTPKSCKKNGFLLYPSSAQYTVINNSEIPGLDTPLLCDTVTDGGGWIVIQRRYTGEVDFYRNWTSYKAGFGSLDNEFWFGNDNIYTITSTGRYELMVEIKYKGQSKFAKYDMFSIDGEEEKYKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B0A4</accession>
    <name>A0A3S1B0A4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_015470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000637">
        <property type="protein sequence ID" value="RUS76763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B0A4"/>
    <dbReference type="STRING" id="188477.A0A3S1B0A4"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="90"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="205"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS76763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="412" mass="46874" checksum="41E7F018B45FC7A0" modified="2019-04-10" version="1" fragment="single">MSSSTGGATVSVQSRQSGRARRGPGTVTVSDDAFSSGRRDSDAPDHAAQAAQAAQAAQTEHQLGQLFQACDLDGSGYIDQAELASICQDLSGEHLGGVFQQLDKDGDGRISVEEFVKGYRDIMMRKETQKRQIIRQRLKSRSEENLADGEVPDSDVEYAAGLGEGLKGLSCQEQVCELYQNLHTAENPELLTQFENIVLNVIHDVRRYQLENERLEKTYQREKDEHLKHLRRLEEEMEQQVQSVEERVRRQEKEKLESEKVELRNVLDSEIVMLQQNLTKLQADGGSNLAKGQEEHLNNLKKRLEEIQHENRMLKSELTDAQTNLALTRSQMTSVKQKLEEKNHELEVENKTVEDYLNEQDKLRRQLQMLHEANKTLLDTNDNLRELLDSSPVATPYKRQGSTDFELGALYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B1S3</accession>
    <name>A0A3S1B1S3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_019317</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001000">
        <property type="protein sequence ID" value="RUS72921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B1S3"/>
    <dbReference type="STRING" id="188477.A0A3S1B1S3"/>
    <dbReference type="OrthoDB" id="407442at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052285">
        <property type="entry name" value="NEXT_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13798">
        <property type="entry name" value="RNA BINDING MOTIF RBM PROTEIN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13798:SF11">
        <property type="entry name" value="RNA-BINDING PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="6"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="90"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="151"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="230"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS72921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="268" mass="30589" checksum="54B230D288ABDA11" modified="2019-04-10" version="1">MAEDEKTLWVGNLDEKVTEELLYELFLQTGPIEKLILPTEGDSDQEKHKGHAYVVFKHPESVQYAAQVLEGSTLFSQALSLKVRSLPVQYKKPSPQQTSTFSTRGRGGRFDNYDSSSLRGGFHMNKSNTWHGQNNSFVPRGRGGYRGRGGYNNFNNYNQSQYQQSNSYSNNGSDQSQSSSTDDDRRQRLLQQQNLTLEAHRQIQQGVMNMTNQMYGTQQQQQQWSNSNNMTNYSSNAGNWNNNQGSTTDQSNMYQGYSDQYGGWYQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B1V2</accession>
    <name>A0A3S1B1V2_ELYCH</name>
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        <recommendedName>
            <fullName evidence="2">Hyaluronan/mRNA-binding protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_019269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000992">
        <property type="protein sequence ID" value="RUS72966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B1V2"/>
    <dbReference type="STRING" id="188477.A0A3S1B1V2"/>
    <dbReference type="OrthoDB" id="6022699at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039764">
        <property type="entry name" value="HABP4/SERBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006861">
        <property type="entry name" value="HABP4_PAIRBP1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12299:SF17">
        <property type="entry name" value="AT19571P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12299">
        <property type="entry name" value="HYALURONIC ACID-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04774">
        <property type="entry name" value="HABP4_PAI-RBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01233">
        <property type="entry name" value="HABP4_PAI-RBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hyaluronan/mRNA-binding protein" evidence="2">
        <location>
            <begin position="182"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="53"/>
            <end position="152"/>
        </location>
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    <feature type="compositionally biased region" description="Gly residues" evidence="1">
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            <end position="177"/>
        </location>
    </feature>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RUS72966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="394" mass="44344" checksum="1DC8C9209785249C" modified="2019-04-10" version="1">MDHQYGIAVQNKFACFFNEDEDPLEILSRQEEQAKSKKKDEGDKKSKSKVKKSAPEVKPKAAEPPAIKREEKTTSARPTERGGRGGRGREPREIRDNDGDKRPPRRQGPRENRDGRVGDENVPPEFRERPEGGFRRREDRGDREGGFGDRGRGRGRGRGRGGRGEGRGGGGFVGQSRGGFDRKREFDRHSGTDRTGIKPIEKRDGGGAHNWGSFKDDLEEQPVQNENTEWANQQEPGTENTEHNESVEGEQVPEEDPQPQEMTLDEWKALQTQSKPKAAFNIRQAGEGEDGSRWTKGREYHKKHDEESDEEEDSEEEEEADHHHGRNKHLVTDIRITFNDNPRRGRGRRGGPGGMDRGSRGSRGSTRGIGGRPRESAPQFDNEADFPSLVKQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B2G1</accession>
    <name>A0A3S1B2G1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_018828</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Gastropoda</taxon>
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            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000940">
        <property type="protein sequence ID" value="RUS73408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B2G1"/>
    <dbReference type="STRING" id="188477.A0A3S1B2G1"/>
    <dbReference type="OrthoDB" id="271725at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12244">
        <property type="entry name" value="RRM2_MSSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000169">
        <property type="entry name" value="protein alan shepard isoform X4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000012">
        <property type="entry name" value="RNA-binding motif, single-stranded-interacting protein 3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002343">
        <property type="entry name" value="Hud_Sxl_RNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00961">
        <property type="entry name" value="HUDSXLRNA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="80"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="159"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="42"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS73408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="264" mass="28866" checksum="9DEBDAECBA4F6019" modified="2019-04-10" version="1" fragment="single">ADSHGRTFRIVTRPASGVKRLGVSPAGLSVILSPVKRDIEVDPSTTVQNYPARSMPANSPNTTSSQSSNQSQSGEPLSRTNLYIRGLNPNTTDKDLVNLCNTFGKITSTKAIIDQTTNKCKGYGFVDFETPQAAELAVQTLQNQGIQAQMAKQQEQDPTNLYISNLPLYFMEKNLENMFKEYGTVISTRILRRPDGISKGVGFARMESKEKCDQIINKFNNKILPGSTDSLLVKFADSGNKKKTAPTALTPRLFTPGRDDGGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B2Y4</accession>
    <name>A0A3S1B2Y4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_018494</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000904">
        <property type="protein sequence ID" value="RUS73757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B2Y4"/>
    <dbReference type="STRING" id="188477.A0A3S1B2Y4"/>
    <dbReference type="OrthoDB" id="6155529at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF34">
        <property type="entry name" value="PR_SET DOMAIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="153"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="326"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="178"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="178"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS73757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="383" mass="43965" checksum="08FEED81968B0C99" modified="2019-04-10" version="1" fragment="single">RLCCDVCGVQFSSGQALSAHIEDKHFVKEEVSNFVCITCGKALRRGMKFHERNFLPENDGQSGTFVNPCPLCSHVSKTKRLLKDHIARKHSRDRKIFRCSKCSFSCLKPGTFSVHMRRHVEEPKFACDQCGKLFLTMSILKRHANTHNKTRQYFCHVQGCGKSFNIKGRLTDHVRTVHNTKKASKVSPHKSKKANNTSCFNERNSLSKSKNESGQKKVQIINQVFVSKKLKWERDIVVYDVVLPENEIERFQNHTTSSHSQIDIIMPEEPNVSHNTPPAEPLTSFKREEQNAQISSKEDDMVSVKPDSIGVDGQCMESYNKQRPNFVCSWDGCGKKFRDSYNLRMHMCTHTGEMQRACTLCRYRCVQKSALDSHMLTHFKKCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B350</accession>
    <name>A0A3S1B350_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_013479</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000491">
        <property type="protein sequence ID" value="RUS78763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B350"/>
    <dbReference type="OrthoDB" id="6480633at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="370"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="330"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="330"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS78763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="407" mass="44428" checksum="FD50876CE716F572" modified="2019-04-10" version="1" fragment="single">MTIFVFRATYNPTKMILYAFLRAYPFLCTSLALSISLHDVLQSKDFQSSGLSFCNTTVTKKTDTILLEDRDLDIGQQCYWHVDVANATSIDILFLPLPSANISSQERTAPSSDNIVPVISVYTNYSGQSPNEVAFSWTFQEVRTVKTFNSSNLWILTNLNINQPDKAFNRTVAISYVARLSGENDKTCSLSGPSPVDQGSFNIIERSFGSIAVLTCDAGFVVPLGSPRVSVCIADEEESEQTSDSNLISLSWSQPHFVCESVCKHPPDVAHATVNLQVDPDTRFTHHAHEQGMDNQSTTTKDMSTNSTAQYTCELPYLMYPHDHSGLLSCRSTTHSSPTTQTGAGEPGSETPAAPSAWGPLPPTCAIPDCSSTIIMSQHSGALVNPSYPSTALYGGRLQCRWEINAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B4W1</accession>
    <name>A0A3S1B4W1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_012302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000419">
        <property type="protein sequence ID" value="RUS79958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B4W1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS79958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="104" mass="12532" checksum="B3570C6127EBF879" modified="2019-04-10" version="1">MDSNVLSVKNQKVLSLFHEWISHIFNDFHKSRNLFDKFSLVQLIFTNLNRRIIPEQLLSLRRYMYTYQTAHYKQCYTWPTLHAKENEPKAPIELRPVFSDNTCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B648</accession>
    <name>A0A3S1B648_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Guanylate cyclase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_015201</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000616">
        <property type="protein sequence ID" value="RUS77021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B648"/>
    <dbReference type="STRING" id="188477.A0A3S1B648"/>
    <dbReference type="OrthoDB" id="10553919at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008074">
        <property type="term" value="C:guanylate cyclase complex, soluble"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019934">
        <property type="term" value="P:cGMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070482">
        <property type="term" value="P:response to oxygen levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.260">
        <property type="entry name" value="Haem NO binding associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042463">
        <property type="entry name" value="HNOB_dom_associated_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655">
        <property type="entry name" value="GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655:SF13">
        <property type="entry name" value="SOLUBLE GUANYLATE CYCLASE GCY-32-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="3">
        <location>
            <begin position="53"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="211"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="317"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="362"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS77021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="449" mass="50098" checksum="651CC2720B0AB754" modified="2019-04-10" version="1">MIWLHDTKHMIFIGSPRLTSLNELIEMNVYLADIPLYDVTRELVLLNQQRIAEIDIADIVTFTNIAAACSPMDIVNMLNEMYQRFDELTSQHKVYKVETIGDAYMIVSGVPETTRVHAQLVANFAMDMVEEAGLVKSPATALPLQDREELDVKGKGKMATYFLCGHLKRRMEELDDDFAALEVYEDSTENGQYVVGPSGLSQDDLVSLDVNGDKAVGDNNTKTDAVDTTFDDDDDDVVYRDDDDDVKDNGGISGEDDEDEEDNADADVERLDEGSCDEEDLHSDHTVDEKVDEVEKCQEKKRRESECLVSINEKVEPARRKISSQSLASGSKQANAAPKLKRGNRKMSRSCNDTAFYSATLTLPHHKGNGHRSASENEIVTNEKTPGRRSGSKTNVGEGGDSECIYVNGSFKNTYRSSMYKGDENSVEFQPAVQFQRTKRYPIATDPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B6J5</accession>
    <name>A0A3S1B6J5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_016054</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000682">
        <property type="protein sequence ID" value="RUS76176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B6J5"/>
    <dbReference type="STRING" id="188477.A0A3S1B6J5"/>
    <dbReference type="OrthoDB" id="347083at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011:SF347">
        <property type="entry name" value="FI21270P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS76176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="12517" checksum="C1AC30156D72D4E0" modified="2019-04-10" version="1" fragment="single">GVPAVLVGVSAALDWQGYGTRSSCWLSIERSTVWVFVGPVVAITLVSLFLSHLIQLCGPQFDQACVVCSRTGAKAGLFLCPLLGLTWISGLAAVSRETVLFQYAFAALNSFQVHSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B6Z4</accession>
    <name>A0A3S1B6Z4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinase</fullName>
            <ecNumber evidence="6">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_018647</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="6"/>
    <dbReference type="EMBL" id="RQTK01000920">
        <property type="protein sequence ID" value="RUS73587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A3S1B6Z4"/>
    <dbReference type="STRING" id="188477.A0A3S1B6Z4"/>
    <dbReference type="OrthoDB" id="338650at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000828">
        <property type="term" value="F:inositol hexakisphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.160:FF:000001">
        <property type="entry name" value="Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF97">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="713"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="896"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1032"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1149"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="756"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="899"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="917"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1040"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1101"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1114"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1149"/>
            <end position="1164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS73587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1480" mass="165169" checksum="B82956ADE4F3F7CB" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B7E6</accession>
    <name>A0A3S1B7E6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_010662</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000330">
        <property type="protein sequence ID" value="RUS81561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B7E6"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS81561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="222" mass="25551" checksum="FF7921E44F01ED6B" modified="2019-04-10" version="1">MQVHDREPIVSHAVFVKDTWGENVYYSNCGGYIFSTVVATSSQLWWPHLLNCGGHIFSTVVATSSQLWWPHLLNCGGHIFSAVVATSSQLWWPHLLSCGGHIFSAVVTSSQLWWPHLLSCGGHIFPTVVLIRFINPKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKGSTTYHLNVKEQTVPMNVAFCDQIIHYTERVTVCALVEHPTHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BEU9</accession>
    <name>A0A3S1BEU9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_013088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000468">
        <property type="protein sequence ID" value="RUS79141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BEU9"/>
    <dbReference type="OrthoDB" id="6140936at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018594926" evidence="1">
        <location>
            <begin position="19"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS79141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="122" mass="13048" checksum="FA0696CA240C438C" modified="2019-04-10" version="1">MLPNALLAALCLVPLASSMYIGGDFGYDPPDQKIFRRNAFGQIQAFDVSHETRLVPNAYGGLSHYNVMEISDPDIYTNTVGAFGMGGGMGGGMGTTMGSRFGTHASRYPSPFSFFNSFPYAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BGV4</accession>
    <name>A0A3S1BGV4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_008940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000249">
        <property type="protein sequence ID" value="RUS83318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BGV4"/>
    <dbReference type="OrthoDB" id="6087204at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS83318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="429" mass="48062" checksum="FBC307465D241215" modified="2019-04-10" version="1">MVENGKTSTAKEYDSDIAQAMLSNTSLEEESVLLEELSLRFSDDIAQPKILKSRRSAGSSRRKSTRWQNPPCSDLTCPEQIVPQDFRVDTGDQQMCFDGTCKVDLPLRESLESSVDSLLFNTHTNNTFQGDQCETKETACNKINVELEENEYREQAQCEESSSEVCKTKSKRKERRSGKFVPVNYGGNPETSSLETLSGEGSNVMSHSNHIGGDAVTDQLMEDLTVLTNVSDAGDKLVHSLAEATDLSNVANSYEESDLNDSCIGIRQSTRSQRTCKRKSWVLPTANDGSSSLTEKQKRGGRKDVNNKTVSETASSDTAKQDTTLTNTQDEFMVDEALRLLYLNKVYKAPPSMRSWETIKESPTNSKNVFIGKRRLRMLTFEEGLTHTRMVRRHRRATIVNELSQNKVVPISQEEFQCKMKSLSSLLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BKF4</accession>
    <name>A0A3S1BKF4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_006356</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the large ribosomal subunit. May bind IPO9 with low affinity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000157">
        <property type="protein sequence ID" value="RUS85872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BKF4"/>
    <dbReference type="STRING" id="188477.A0A3S1BKF4"/>
    <dbReference type="OrthoDB" id="2436667at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13156">
        <property type="entry name" value="KOW_RPL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000014">
        <property type="entry name" value="60S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000915">
        <property type="entry name" value="60S_ribosomal_eL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041997">
        <property type="entry name" value="Ribosomal_eL6_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01159">
        <property type="entry name" value="Ribosomal_L6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS85872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="208" mass="24163" checksum="EFBFBDA094C628CE" modified="2019-04-10" version="1">MPTTKEPTVVAKKVGGDKNGGERQVRVKRMPRWYPTEDKPRKLKNHKIAFNQHKRKLRESITPGTILILVAGRHKGKRVVFLKQLNTGLLLVTGPYHLNGCPLRRINQRYVIATKTKLDIKGVKVPDRVNDEYFKRQKSKKPKHTEGDIFSTEKEVYTVSDERKEDQANVDRQILDVIRKQKEKKLLFGYLGSMFSLSNNQFPHKMVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BMF0</accession>
    <name>A0A3S1BMF0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_005125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000119">
        <property type="protein sequence ID" value="RUS87125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BMF0"/>
    <dbReference type="OrthoDB" id="9943385at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS87125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="183" mass="20703" checksum="76D9B9A079B653CF" modified="2019-04-10" version="1">MSGRRKQTNSDTRCVTLVKHKQGKWGLALGLVTLEINTDFATLETNTDFATLETNTDFATLETNTDFGTLETNTDFATLETNTDFATLETNTDFATLETNTDFATLETNTDFATLETNTDFETLETNTDFETLETNTDFETLETNTDFETLETNTDFETLETNTDFETLETNTDLHRLYDFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BPH8</accession>
    <name>A0A3S1BPH8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_003854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000084">
        <property type="protein sequence ID" value="RUS88398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BPH8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS88398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="23844" checksum="7AF46CB23E7672AA" modified="2019-04-10" version="1" fragment="single">FYLYFSLSLSISLSLSPFNSYLSIYLSIYLSIYLSIYLSIYLSIYLSIYLSIYLSIYLSIYLSQTHFTMVRFIFNKSIKNSDAMFKCALHFKIIYLSIYLSIHLSIYLSIYLSIYLSIYLSNYLSIYLSIYLSIYLSTYLPTYLPVYLSMYLSIYLSIYLSIYLSIYLSIYLSVCLSVCLSICLSVCLSVCLTVYLSIYLNICI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BQG2</accession>
    <name>A0A3S1BQG2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_005990</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000145">
        <property type="protein sequence ID" value="RUS86248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BQG2"/>
    <dbReference type="STRING" id="188477.A0A3S1BQG2"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000010">
        <property type="entry name" value="Cyclic AMP-dependent transcription factor ATF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002112">
        <property type="entry name" value="Leuzip_Jun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00043">
        <property type="entry name" value="LEUZIPPRJUN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="10"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="BZIP" evidence="10">
        <location>
            <begin position="476"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="87"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="343"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="423"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="501"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="343"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="423"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS86248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="604" mass="65089" checksum="F4BFDA830F350CF4" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BXS7</accession>
    <name>A0A3S1BXS7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_014625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000566">
        <property type="protein sequence ID" value="RUS77625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BXS7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS77625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="330" mass="36453" checksum="6035C09C12BEC203" modified="2019-04-10" version="1">MEALHLSIGRRDGVSPAAALRRRCLSGLSPNTGDFGIVSTLNICVEFYDNGRSGLCKGTTMLGFEPLNSLFLFLLAAFFRICHMCAMAVQKAGIGLTVLPSVLSQSPLPQRQNTDVRLDVVWLWTKRWHLKKRIGLGIYHYGVTLRNKYPNCKHVGADVESKVRTKVLVLILSPLEHSTKSSPEWSFVTLLASPTIPFSALLTAKTLIFAHLFVDFADHLKRQTVANILYTPPNEGPVTTRAGGRSNRREKEQEGGRAEGGRAEEGRAGGRESRGRGTRREIEQKSGRAGGRGSRRKEKEGGRAMGGRGGRKSNWRKTRKKEQSEEEEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C2M8</accession>
    <name>A0A3S1C2M8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">40S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_011035</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000350">
        <property type="protein sequence ID" value="RUS81205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C2M8"/>
    <dbReference type="STRING" id="188477.A0A3S1C2M8"/>
    <dbReference type="OrthoDB" id="1727351at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.20">
        <property type="entry name" value="Ribosomal protein S17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001210">
        <property type="entry name" value="Ribosomal_eS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036401">
        <property type="entry name" value="Ribosomal_eS17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00833">
        <property type="entry name" value="Ribosomal_S17e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116820">
        <property type="entry name" value="Rps17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS81205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="84" mass="9526" checksum="91F022D11834F99D" modified="2019-04-10" version="1">MARVRTKTVKKAARVIIEKYYTRLTNDFHTNKRVSALDMEIIEIDPDTKEMLKSLDFGNMPSLQVTQPTPSFTSGRAPQGGIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-05-03" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C4N6</accession>
    <name>A0A3S1C4N6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_009397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000268">
        <property type="protein sequence ID" value="RUS82875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C4N6"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS82875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="161" mass="20746" checksum="3802BDD538FB6116" modified="2019-04-10" version="1">MWLDRSDRRRETRDMAEMWLDRSDRRRETRDMAEMWLDRSDRRRETRDMAEMWLDRSDHRRETRDMAEMWLDRSDRRRETRDMAEMWLDRSDRRRETRDMAELWLDRSDRRRETRDMAEMWLDRSDRRRETRDMAEMWLDRSDRRRETRDMAELQSIITIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C8G7</accession>
    <name>A0A3S1C8G7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_006377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000157">
        <property type="protein sequence ID" value="RUS85893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C8G7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS85893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="415" mass="45592" checksum="F2F7B446746B92A7" modified="2019-04-10" version="1">MERSNPVSWKRSNQEEMNDDCSVISATTGGSLSPLLLPCIQRNGIASTTKHKKFNFPALHFSNVSPVIPLQCWSKTSDDDQEFSCMEMSGEEIINSSESSISATALLSAKQPKCLNELSEGPELEMSAQLIMVKENVSGKSNPKNSVESPLNSGWGEVTGTRNQRLSKSFEIFNELPTSSIPNHKDCYTDALTSGTCVGNTDSRTPEIQLSGKRQCLASPNQDLTLPQTVDGERHTLVHSGKKSSLPQTVDGEMTGSRHKFTLHQTVDGDRHTLAHTGQKSTLQIQEDVALTDLQPEKYPCKTCSQELERTSEVQHAPSLSVPESPQTQHSDPRRITGPASLSHCQIVDREMPEEQTLHQQQDHQYTGSDATLSPALVLPEQMSQNPSLNDSQNNTEEKRSQSQNNMGGKESPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1CAU6</accession>
    <name>A0A3S1CAU6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_004552</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000103">
        <property type="protein sequence ID" value="RUS87711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1CAU6"/>
    <dbReference type="OrthoDB" id="10252017at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043:SF8">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS87711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="14769" checksum="74C1F8A162F80B73" modified="2019-04-10" version="1" fragment="single">CSNNTYGENCLESCSINCAGADNACNHVNGSCLQGCVDGYGGETCEYPCSNNTYGKNCAGNCSINCAGADNACNYVNGSCLLGCVDGYEGETCESPVTDTEKSADLYEDDLPEASVDIIRMSDGIGYFMLILLICLVVGVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1CCH7</accession>
    <name>A0A3S1CCH7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_003274</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000070">
        <property type="protein sequence ID" value="RUS88938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1CCH7"/>
    <dbReference type="OrthoDB" id="6039838at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050828">
        <property type="entry name" value="C-type_lectin/matrix_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45710">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN 180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45710:SF26">
        <property type="entry name" value="RH26557P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018609544" description="C-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="29"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="141"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS88938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="31143" checksum="9A6C8AA464977F16" modified="2019-04-10" version="1">MAGAGAHSLAVLWIVHIFAGIHGDQVTLVDTRRFKSSKSKTPQMLWLTDKASFQAQTLSECATKCRERPQRDCFSFVYNDLENKCQLGSWTAADGNMVAEQCLHDPDPSKFKKQPLVNNVGKLFTSACCEGDFMVRTLSMKVAKCLFYSTQRRNFNEAKADCQNKNSRLITFKTVAEMEFVQELLSCIDEIWVGIEDNCDYPGIDCGVVGARKLFWVDNSEVTGNVKDVVFKKLDNKVREGCIHLGGKFKDTFNDGQCSSSFYYVCEKDLQDETYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H534</accession>
    <name>A0A3S1H534_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_019871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001075">
        <property type="protein sequence ID" value="RUS72373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H534"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018580909" description="MAM domain-containing protein" evidence="1">
        <location>
            <begin position="33"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS72373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="14249" checksum="54B7519E13A4A132" modified="2019-04-10" version="1" fragment="single">MMKALFYMDPLHLLVLHLPLLAMMSCSMGTLTAPSSRCSDSRAGLPSCDFNQKNCYTEPGGETPGWKLLPQWDSGPVDKDEGAYMYLEPAISKGNPKKLIGRIAKDKTAICVDMSYNTAGNESVPINLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H9F8</accession>
    <name>A0A3S1H9F8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_017401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000794">
        <property type="protein sequence ID" value="RUS74844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H9F8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS74844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="106" mass="11894" checksum="300F20701C2A2BB9" modified="2019-04-10" version="1">MAAKGRASKRKQEQKGGRGGRKSNREEEQEGGRAREEEQEGGRAGGRKSRREEEQEGGRAGGRKSRREESRREEEQEGGRTGGRKRRREEEQEGRRVEGGASGART</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HBK5</accession>
    <name>A0A3S1HBK5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulfatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_016249</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="6">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000694">
        <property type="protein sequence ID" value="RUS76004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HBK5"/>
    <dbReference type="STRING" id="188477.A0A3S1HBK5"/>
    <dbReference type="OrthoDB" id="96314at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005539">
        <property type="term" value="F:glycosaminoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008449">
        <property type="term" value="F:N-acetylglucosamine-6-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16147">
        <property type="entry name" value="G6S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012251">
        <property type="entry name" value="GlcNAc_6-SO4ase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108:SF8">
        <property type="entry name" value="SD21168P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036666">
        <property type="entry name" value="G6S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018784611" description="Sulfatase N-terminal domain-containing protein" evidence="7">
        <location>
            <begin position="22"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="31"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="6">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR036666-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS76004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="508" mass="57188" checksum="91C4844A6A18531F" modified="2019-04-10" version="1">MDVRLASWMPLLVIFVHLASYSVVNSKAGKPNIVFVLTDDQDVVLFGQQPMAKTHKLLTEQGMLFENMFVSSPLCCPSRASILTGQFVHNHNTQNNSVNGGCSGQTWQKQAEPKAFNTYLKAEGYKTFFAGKYLNQYGLEKSGGVKHVPPGWDEWHGLVGNSVYYNYSLSVNGKEEKHGDNYTEDYLPDLIHRRGLDFLSRQSDRRPFFMMLSTPSCHKPFTPAPQYEKSFQDEQAPRTASFDTKGKDKHWLVGAALNPMPVDVIKIIDENYRLRHRTLLSVDDMVEGVYNKLKDMDLLDNTYIFFSSDNGFHLGQFSLPEDKRQPYEFDIRVPLIVRGPGIKPNTTSIESVTNVDLAPTFVDLSGSKAETAKFDGMSFAGILRGQAHAFRSTVLVEYYGEEEVKEVQCPQLSNQHLKGCTKEFHCVCVDSQNNTYGCIRYENAKQSFKFCEFQDASNTIEVYDLNGDPHELNNIAKSAPPELLSKLTDKLAKLSLCAGTGCHDKTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1I0F4</accession>
    <name>A0A3S1I0F4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_002475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000048">
        <property type="protein sequence ID" value="RUS89772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1I0F4"/>
    <dbReference type="STRING" id="188477.A0A3S1I0F4"/>
    <dbReference type="OrthoDB" id="6162636at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053121">
        <property type="entry name" value="Spore_Coat_Assembly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35365">
        <property type="entry name" value="LP04239P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35365:SF18">
        <property type="entry name" value="MUCIN-19-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69360">
        <property type="entry name" value="Cell wall binding repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS89772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="583" mass="59519" checksum="B533EF229D306E98" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1I2T1</accession>
    <name>A0A3S1I2T1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_001048</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="EMBL" id="RQTK01000017">
        <property type="protein sequence ID" value="RUS91135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1I2T1"/>
    <dbReference type="STRING" id="188477.A0A3S1I2T1"/>
    <dbReference type="OrthoDB" id="3370at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17956">
        <property type="entry name" value="DEADc_DDX51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="149"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="405"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS91135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="581" mass="65829" checksum="70479F7BEE79E970" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SI53</accession>
    <name>A0A433SI53_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_023701</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01002404">
        <property type="protein sequence ID" value="RUS68538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SI53"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS68538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="317" mass="36244" checksum="184622847B8A4B40" modified="2019-05-08" version="1">MAPWPLFNLSTQPATPLTGRHRVASCSHELTSKKQLTWEQQTLQEWKIFTWEQQTLQELTRETILTWEQQTLQELTSKKQLTWKQQTLQELTRETILNWEQQTLQELTSKKQLTWEQQTLQEWKILTWEQQTLQEWKILTWEQQTLQEWKILTWEQQTHLGATNIAKEEDSHLGATNIAGVNQGDDSHLGATNNARVEDSHLGATNIARVNQEVDSHLGATNIARVNQEDDSHLGATNIARVNQEEDSHLGATNIARVNQEEDSHLGATNIARVEDSHLGATNIARVEDSHLGATNIARVEDSHLGATNIARKILTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SIF0</accession>
    <name>A0A433SIF0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibrinogen C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_023524</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01002072">
        <property type="protein sequence ID" value="RUS68715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SIF0"/>
    <dbReference type="STRING" id="188477.A0A433SIF0"/>
    <dbReference type="OrthoDB" id="6273946at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="2">
        <location>
            <begin position="15"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS68715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="235" mass="26821" checksum="69034ABA68926CA1" modified="2019-05-08" version="1">MSYSAAISNFFPFRLLAYAQVLECKRGMGDDVTKWYQPYVKVTDSATENPLLCDTHTDGGGWIVIQRRINGDEDFYRGWDDYRNGFGSIDGDFWIGNEFINTLTNENEYELRIDMKVDGKDEFAYSSNFSLTDEADSYRLKLGKVWGTVSAKGLEYQKDQQFTTFDVDHDTWPAGNCAEKFHGAWWYQACHHSNLNGAWNQTGPTGVAWISGGSWINPTFTEMKMRRVASLVLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SJP3</accession>
    <name>A0A433SJP3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_022914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001728">
        <property type="protein sequence ID" value="RUS69322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SJP3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS69322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="263" mass="27957" checksum="71656F3864757825" modified="2019-05-08" version="1" fragment="single">MLKRQTRYSKAIVTQNPNDSSVYLDVNSPTDTKISMTTSSNLSVSGGDCNSQPIEGSRIKTVPKQATKKGPISIPLVVLQADNVPKSLHSSKTSPPSERHTSRGCGPPTTAGARQQPGPRPAASDNTNTSAMPRRIAREEPPEGKPSSMLLQTLFPSAKQSRSSNMRVQNRASSTGPPKVGVTEFKFLPTSGQGRQERNPLGGGRKASFKVWASESIPPGSEKEVMRASTASIKKPQVKSVGVNRFSVVPLDKVQGKASSAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SM95</accession>
    <name>A0A433SM95_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_021970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001446">
        <property type="protein sequence ID" value="RUS70293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SM95"/>
    <dbReference type="OrthoDB" id="10536552at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS70293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="600" mass="68257" checksum="B9768B0752A8BCC1" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SMG4</accession>
    <name>A0A433SMG4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_021863</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001424">
        <property type="protein sequence ID" value="RUS70377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SMG4"/>
    <dbReference type="OrthoDB" id="10011262at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="50"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS70377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="347" mass="39063" checksum="A81FA8C37D69319C" modified="2019-05-08" version="1">METNCSNSSEIAGLCVAEKPVIPPFEKELAIGLKVLAPLWPVIITFGLCSNITNIIVFLQAGVKENVTTLLLSLSLSDLTFLVLITPSMCGFFIKAYPENHSWPFDYKFSWYLLYWPAFTAYDLSAFISVSLGVMRCACVAMPLKFKIVFTKSRTIKWVLFLVVLAVALRVPVLTIFRIQFRKHVNPPNNSSNLIPFLAMVNRDPMSRINDVMNRGFVIWFNYSTMITCVCVLTLKLRQAYKIRRFCTAGSLPHSNATGEKTLKTDGRRLQSKDLQVIKSVVLVCTIFILSQLPFLVISTSRFNTVSTTTDNTGFVMSMTITGDIITTFRLGVSDPHWLLVSKLEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SNK5</accession>
    <name>A0A433SNK5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_021433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001330">
        <property type="protein sequence ID" value="RUS70813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SNK5"/>
    <dbReference type="OrthoDB" id="6149959at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS70813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="620" mass="70028" checksum="52B13DCBD4BD4AD6" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SNM1</accession>
    <name>A0A433SNM1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Regulating synaptic membrane exocytosis protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_021420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001328">
        <property type="protein sequence ID" value="RUS70820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SNM1"/>
    <dbReference type="STRING" id="188477.A0A433SNM1"/>
    <dbReference type="OrthoDB" id="10059918at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048788">
        <property type="term" value="C:cytoskeleton of presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050806">
        <property type="term" value="P:positive regulation of synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048167">
        <property type="term" value="P:regulation of synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041282">
        <property type="entry name" value="FYVE_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010911">
        <property type="entry name" value="Rab_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039032">
        <property type="entry name" value="Rim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12157:SF21">
        <property type="entry name" value="RAB3 INTERACTING MOLECULE, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12157">
        <property type="entry name" value="REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02318">
        <property type="entry name" value="FYVE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50916">
        <property type="entry name" value="RABBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="RabBD" evidence="7">
        <location>
            <begin position="33"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="646"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="5">
        <location>
            <begin position="781"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="5">
        <location>
            <begin position="1117"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="228"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="299"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="440"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="533"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="582"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="949"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1010"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1096"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="55"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="440"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="533"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="984"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1016"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1075"/>
            <end position="1084"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS70820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1268" mass="141862" checksum="7DD74DE74F9B1C4E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SS79</accession>
    <name>A0A433SS79_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_020104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001107">
        <property type="protein sequence ID" value="RUS72131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SS79"/>
    <dbReference type="OrthoDB" id="774951at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS72131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="385" mass="41945" checksum="E6B766EC889A554B" modified="2019-05-08" version="1" fragment="single">MLPSAPSCRERDPFSGRGTGQVDFQHTSLRRTRSRKKRRMQEMEERQRIRGDSHWSKVLQVNAEDASWFENKRGTRMCQSFHFGQRSSFRAARDKCVTTKPAATGAVGTASVAKPVLCACPPKAEPSGSAGTSTSVTATNATTADDVPSKNAEPGILASLFSKIRQWLQSKRRYEVSPGGGGPRGKEAAREGSSAKDDSANGARRESIKEDYLIISKVNNYHPELKRSEAAYTHSHYHHHQMAASKSSSAISSFTTIRGYSSTASPVLIAYKSKTSSTVAQTIVGGKPAVDINIELVENSSSTPVELKSHFKANPLKLVNAQTPAPCKTAMMTPISRVLSRSQQLRQSRNKYMKLLQKTGQLSPGRSPLTGTISAPAKHSLSDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SSW4</accession>
    <name>A0A433SSW4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_019888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001077">
        <property type="protein sequence ID" value="RUS72352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SSW4"/>
    <dbReference type="OrthoDB" id="6090078at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS72352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="486" mass="55401" checksum="A6251C1C54E9EB30" modified="2019-05-08" version="1">MASKLYPTLSSFYKAGNVEFGSERDAMLCGVPEEKLYRKPSRQRKVLHAQNIPPPGQPEAPEPTTDRAELYDRNRDAQFSPMPQAHHERGSVSPPLTPSAPPLLEMLDLRLQQYLNVLLDSNDTTNINQFLQSTDNPALSLLSPSNTDSDNNSSHTTVTLPLPPNVAVEESWLSEIRPDYDDITPEEMADEILNNLNVVREEDVKDHEKHKSLSLFKMPKDLQGEAERRGLQPQSQRQHHDLRHRHAHQRQESQDSRDDNVDTKDNQIPRDFQQQPHWHHHHHHKSHGASRLRERELRDRDDTRLAGKTKRQERTERPAPGANTESAGRDRRRDAHPQRISSHAPRARDDTGKSTADLTEAQRETGKPSARRKSSVAEKENQSRSPGRAEVQGEKSDYNAWMTWRKQVNRQLATIILLKQQGRQVSVQTTDMRRTSLRQSSIDFVSQIATQSGSTTSLGGKPYVMYGIPRASLLPKNETAERKRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433STN7</accession>
    <name>A0A433STN7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_019605</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001041">
        <property type="protein sequence ID" value="RUS72631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433STN7"/>
    <dbReference type="OrthoDB" id="6206419at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24230">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="300"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="126"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS72631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="350" mass="39175" checksum="164E753E5705482A" modified="2019-05-08" version="1">MASHNSTMALTSMGADITETGEFRDLAFEYASLILKTYVNVALSFGGIVANVINFMVFYTMGVSDGITQNFLILSFFDGMVAATYMVNSISYTLFYSVFTAGDHISEILNNIFFATFIGQHYCLQVSYMTTTVTAVVRCCCVAMPLRVKRVMTVRRQLIIIALFSLNALIVNLIAALLGDTVPLIRPGDNLTQYSDFQDPMYLICDIMAHSLITVEYIIIVVCTIILIYSLYRSSKFREQSGSSSEAFEKRNANARETRVVQTILVITTVFIFCNIPYLTLTALRQLVPAVTATGHLWKLHTIILFVQEAGVLINANANCFGYFYFNTRYRNTLKNLFGKAVNVVKSDHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SUB4</accession>
    <name>A0A433SUB4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cation efflux protein transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_019363</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001006">
        <property type="protein sequence ID" value="RUS72876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SUB4"/>
    <dbReference type="STRING" id="188477.A0A433SUB4"/>
    <dbReference type="OrthoDB" id="435980at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040177">
        <property type="entry name" value="SLC30A9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13414">
        <property type="entry name" value="HUEL-CATION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13414:SF9">
        <property type="entry name" value="PROTON-COUPLED ZINC ANTIPORTER SLC30A9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="7">
        <location>
            <begin position="5"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS72876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="224" mass="24827" checksum="9D322F060FD79E20" modified="2019-05-08" version="1" fragment="single">RHKILTYFISFLFSATLLVAINQVRKSSRALDMTFREYLIRGVDPNVNVVLLEDLAAVVGVGIAATCISISAYTGSPLADAVGSGLIGTVLGGVAGFIIYQNTYQLVGRSIPLDERQDISQLLETDRMIRSLHDIKATEMGGIVRYKAEVDFDGREITRAYLYKQDIDAMLLEAQGLETTEDLEKFMLNHGEKIIDALGAEVDRIEKSLKTKHPEIRHVDLEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SV13</accession>
    <name>A0A433SV13_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA polymerase delta catalytic subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">3'-5' exodeoxyribonuclease</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_019097</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000973">
        <property type="protein sequence ID" value="RUS73135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SV13"/>
    <dbReference type="STRING" id="188477.A0A433SV13"/>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.730">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050240">
        <property type="entry name" value="DNA_pol_type-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056435">
        <property type="entry name" value="DPOD/Z_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322">
        <property type="entry name" value="DNA POLYMERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322:SF23">
        <property type="entry name" value="DNA POLYMERASE DELTA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24055">
        <property type="entry name" value="POL3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase delta/zeta catalytic subunit N-terminal" evidence="6">
        <location>
            <begin position="132"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="5">
        <location>
            <begin position="231"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00042791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS73135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="382" mass="42581" checksum="3A5706DA34885174" modified="2019-05-08" version="1" fragment="single">MTGKRAANGGPPPAKQSRMDFDEDDNPSQFEEELALLDEIEAEGRGSGSETMDTYAPGPDVESTDFNAKWLRPPLPSLDPKKDSVAFQQLELDYYIGTHLQGMPGATKGPTPIVRMSGVTMEGNSVMAHIHGFTPYFFVPAQPGFKREDCERFKNALETVVKKDLRSNREGIVDAILAVDYVMRESIYGYHGNRKVPFLKITVALPRLIAPAKRMLEQGFVCPGYSQFGFQSYESNIDFEIRFMADTDVVGCNWIELPPGKYYVRPSSQHSGQTSSSSSSLSMVSRCQLEVDISWEDFISHPAEGEWSKVAPFRILSFDIECAGRRGIFPEPNTDPVIQIANMVIRQGDSDPFIRNVFTLKSCAPVVGSKVLSYDTEFELLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SWG5</accession>
    <name>A0A433SWG5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_018632</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000918">
        <property type="protein sequence ID" value="RUS73609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A433SWG5"/>
    <dbReference type="OrthoDB" id="9990384at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000020">
        <property type="entry name" value="Dachsous cadherin-related 1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF422">
        <property type="entry name" value="CADHERIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="14"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="1699"/>
            <end position="1725"/>
        </location>
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            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
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            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
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            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
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            <end position="457"/>
        </location>
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    <feature type="domain" description="Cadherin" evidence="11">
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            <begin position="458"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="573"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="686"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="802"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="919"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="1026"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="1138"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="1252"/>
            <end position="1360"/>
        </location>
    </feature>
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        <location>
            <begin position="1370"/>
            <end position="1489"/>
        </location>
    </feature>
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        <location>
            <begin position="1490"/>
            <end position="1582"/>
        </location>
    </feature>
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        <location>
            <begin position="1872"/>
            <end position="1891"/>
        </location>
    </feature>
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            <begin position="1882"/>
            <end position="1891"/>
        </location>
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            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS73609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1891" mass="208622" checksum="AEAEF63765C6B583" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SX96</accession>
    <name>A0A433SX96_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_018306</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000884">
        <property type="protein sequence ID" value="RUS73934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5970758at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
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    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="830"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="462"/>
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            <end position="577"/>
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            <end position="776"/>
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            <end position="1095"/>
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            <end position="1229"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="1396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
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        <location>
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            <end position="109"/>
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            <end position="147"/>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="1357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS73934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1440" mass="158965" checksum="B15BA7AF61B941AE" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SXR8</accession>
    <name>A0A433SXR8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">V-type proton ATPase subunit E</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_018175</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase E subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000870">
        <property type="protein sequence ID" value="RUS74068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SXR8"/>
    <dbReference type="STRING" id="188477.A0A433SXR8"/>
    <dbReference type="OrthoDB" id="10263003at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033178">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, catalytic domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.30">
        <property type="entry name" value="ATP synthase, E subunit, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038495">
        <property type="entry name" value="ATPase_E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002842">
        <property type="entry name" value="ATPase_V1_Esu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45715">
        <property type="entry name" value="ATPASE H+-TRANSPORTING V1 SUBUNIT E1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01991">
        <property type="entry name" value="vATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160527">
        <property type="entry name" value="V-type ATPase subunit E-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS74068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="26061" checksum="2823948044AE5ACA" modified="2019-05-08" version="1">MAGMSDADVQGQIAHMIAFIEQEASEKVEEIECKAEEEFNLEKGRLVATARAKIIEHFDKKIKQVELQKKIQHSNLLNASRLQVLKHKEKLVNNLFESISSDSARISQDDAQKYRKALTDLTLQALCRLLEPRVTVLVRQQDFQLMQSLIPGIQESYVGLTKGKYQVDISIDEQNFLSADLIGGIVMTAQNGKISINNTLDERLKHIGRQMQPQIRGMLFGPNPNRTFND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SZ13</accession>
    <name>A0A433SZ13_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="2">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_017724</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="2"/>
    <dbReference type="EMBL" id="RQTK01000824">
        <property type="protein sequence ID" value="RUS74517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SZ13"/>
    <dbReference type="STRING" id="188477.A0A433SZ13"/>
    <dbReference type="OrthoDB" id="6275502at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.70:FF:000011">
        <property type="entry name" value="Phosphatidylinositol 4-kinase alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF15">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIK helical" evidence="3">
        <location>
            <begin position="9"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS74517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="217" mass="25172" checksum="61E2CA65D2771E4C" modified="2019-05-08" version="1" fragment="single">RHSFTEKQWRDIANYSWELSPTLAVYLPFRFRNCETLRKEATRLVSINPDSVSHIPEAINFLVTATSVEMDVPELSHIMTWEKVSPVLALSYFSRLYPPHPLTAQFAIRVLRAQPSEVLLFYIPQIVQALRYDPMGYVSEFILWAAGKSQLLAHQLLWNMKTNIYHDEEATMKDEFIGTKLEEMIEEICKNLSGSALSFYKREFEFFGEITNISGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T186</accession>
    <name>A0A433T186_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_016931</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000753">
        <property type="protein sequence ID" value="RUS75310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T186"/>
    <dbReference type="OrthoDB" id="6154504at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS75310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="117" mass="13289" checksum="AB93FA78C606CACA" modified="2019-05-08" version="1">MVTRRSFEVIFTQSKIIRNSTKENGTKRNVFARRRKPVTVPHKVDSEEIRKGQVVSEARESDDVERAVAKRLARWPEGNEIVALLMLLKTEQVCASYCPSAPLSLKRPTSEDSFATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T4D1</accession>
    <name>A0A433T4D1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_015845</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000666">
        <property type="protein sequence ID" value="RUS76394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T4D1"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052983">
        <property type="entry name" value="MFS_Riboflavin_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43385">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER RIBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43385:SF1">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER RIBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS76394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="465" mass="50884" checksum="73EC117FEAAC901A" modified="2019-05-08" version="1">MGMCKERFAKVATLVGVHLLTAPSSFLWNYGNLSAYMESYFHVFCFPGCVDGDSQWIINLYVASFCPGLCLSRPLCNYLGMRWSGIVAMIICNAGLISSAWSIKVSVMGTSLLMGLLCGLGTGTSLCTAFMYVNAWVVKNKGLFVATVTSAPTILSILQNQMITMYVNPKNLKPDTAIGPKTYFSDLALLKRVPNIVFILGLMTFVLQLLGNILVSDPPSTPKTTSTDKTQKSIILKNGTYDTKSALEPDGEKTKDIEIATATTEQLPRPLKALEVLKTGSFKALWLYVVALMYGLILKNNYYKQFGLLYIENDKFLTLVGSLIPVTASITRIAFGGLLDRNILSIKDCMIITLSVNSLLCDFWWFAPQVNGLFYMILILSMASMHSVTYTLAATGTLQVFGPANFATNFALVYTAATVTSIVTALTVNPLLQALGWFWLFTSCGIVSGVALFSTIVINMEKKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T593</accession>
    <name>A0A433T593_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_015496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000639">
        <property type="protein sequence ID" value="RUS76740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T593"/>
    <dbReference type="OrthoDB" id="6409159at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006689">
        <property type="term" value="P:ganglioside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.220.10">
        <property type="entry name" value="Ganglioside GM2 activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028996">
        <property type="entry name" value="GM2-AP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036846">
        <property type="entry name" value="GM2-AP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17357:SF0">
        <property type="entry name" value="GANGLIOSIDE GM2 ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17357">
        <property type="entry name" value="GM2 GANGLIOSIDE ACTIVATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63707">
        <property type="entry name" value="Ganglioside M2 (gm2) activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019093291" evidence="2">
        <location>
            <begin position="25"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS76740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="123" mass="13442" checksum="E92B4480B0EE92E3" modified="2019-05-08" version="1" fragment="single">MILTYRETWRSVLFLFLGFVGVRADFSSCNNEQPGNQISASYTLSNSRIPVPGQFTASLQVQLATAIDDNVRAEVDINRRVFYWSVPVPCVGSGQGFGSCSYSDLCALLNAVTETCSGQPCRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T6Q3</accession>
    <name>A0A433T6Q3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_015005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000597">
        <property type="protein sequence ID" value="RUS77230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T6Q3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS77230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="134" mass="14183" checksum="BF96566962B9D9E7" modified="2019-05-08" version="1" fragment="single">LHSDAGRVLAIAALVELDHLSALVSRGGVQGVELAHVGPQLLHRARAESVAGRDQHAEPVLHQPEANLATENHRGDVRRLPDAVDPTEGDHVRPLVLARVHSVSQNVHPAARGQDLYTGVGQGGLHSGRDAWSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T6S2</accession>
    <name>A0A433T6S2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_014983</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000595">
        <property type="protein sequence ID" value="RUS77250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T6S2"/>
    <dbReference type="STRING" id="188477.A0A433T6S2"/>
    <dbReference type="OrthoDB" id="6155320at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="95"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS77250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="426" mass="46714" checksum="4D54DAC0A4B91C03" modified="2019-05-08" version="1">MVATSNFNFSTTLLISNTFSNGLAGSELALGLSSNESAISAMPGAGAVSDGGGGGELYSPGNASGTSAMEEVLKATVNGLNTYAVPIICVLGIIGDVTSFLVFVISSFRYHPCSQYLAALAFVDTMFLLSQLINSLMTFFPSLAFAPGYCSVMVFLAYVCSFLSAWFVVLMMVERYIAVCHPFRASALCNKRKSIMVIAGLSLFSVLLYSHSFFTTIESRPCSIDAGSYGFLIVFTYLDSFLVLVVPFLAIVLLNLKVIFTVRGFRRQHNLLGSSVNGHHGKACAGSCHNSNNNSTGTACSTSTTTLRFHTSSKTLSLAQVRSTKMLVWVSSVFLVLYLPSYAARLYGLILQQAAGGFKSERQRLHFQIAQQLCQFLYFLNFAIDFLVYLVTSNNFRRNIRRFIKNIRVREKRSSIRRRPGVRGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T787</accession>
    <name>A0A433T787_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CTCK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_014832</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000583">
        <property type="protein sequence ID" value="RUS77413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T787"/>
    <dbReference type="STRING" id="188477.A0A433T787"/>
    <dbReference type="OrthoDB" id="6042322at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006207">
        <property type="entry name" value="Cys_knot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004133">
        <property type="entry name" value="DAN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03045">
        <property type="entry name" value="DAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00041">
        <property type="entry name" value="CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018973165" description="CTCK domain-containing protein" evidence="5">
        <location>
            <begin position="26"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="CTCK" evidence="6">
        <location>
            <begin position="30"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS77413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="226" mass="25156" checksum="E456A08B72E8686F" modified="2019-05-08" version="1">MDTSERYNRHFLAGLLFMLLPSTEASACSLHRSVHTVRFRQCVLRVLSFTCRGTCDSYSSPNPADLMSIIRNCNCCTETGFRTASIPLRCPIPDGESGTINTHVRVKIPTGCSCRPCEPVPTIEPDFSLIKYVFYRFSSSPIAGVLRGSNKNLVNASVVVSVWDYNYKSRDDFVGRVVIGHHASGPQESQHWDRMLQSQRSPVAQWHSLKSRADCDQVSLASIAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T8D7</accession>
    <name>A0A433T8D7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_014486</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000555">
        <property type="protein sequence ID" value="RUS77754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T8D7"/>
    <dbReference type="STRING" id="188477.A0A433T8D7"/>
    <dbReference type="OrthoDB" id="10645394at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS77754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="123" mass="14173" checksum="D2695D5FECEBA6A4" modified="2019-05-08" version="1" fragment="single">SPLLQTFLKLDSPLLQTFLKLDSPLLQTFLKLDSPLLQTFLKLDSPLLQTFLKLDSPLLQTFLKLDSPLLQTFLKLYSPLLQTFLKLDSPQLQTFLKLHSLLLQTFLKLYSPLLQTFLKLDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TB03</accession>
    <name>A0A433TB03_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_013477</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000491">
        <property type="protein sequence ID" value="RUS78761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TB03"/>
    <dbReference type="STRING" id="188477.A0A433TB03"/>
    <dbReference type="OrthoDB" id="6119737at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000007">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Peptidase A2" evidence="8">
        <location>
            <begin position="88"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="9">
        <location>
            <begin position="265"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS78761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="51268" checksum="F29D27034E6B6639" modified="2019-05-08" version="1">MSIETVALKLPTFWTTCPSAWFAQTEAQFALRGITADETKYYHVVAALDPDTASRSLSVISSPPPTSTRPTSEPKISQLFVTDEKSKRRFLVDTGAQVSVTPASWADKVSGTTGPNLQAANGSSIATYGSRVVHLHFGNRVFDARLISANVKRPLLGADFLRQHNLLVDIRGHRLIEADSFSHINCSVSSISVDPVLAPIEPTSNKFRKILNGYPELLQPTFSTAEVKHGVKHFIPTKDRPVFARARRLAPDKLASAKQEFLEMEKMGIIQKSNSPWASPLHMVPKSNGGSRPCGDYRRLNDATVPDRYPIPHIQDFSARLAGKNIFSKIDLVRGYHQIPVAPEDVPKTAVITPFGLWEFLRMPFGLKCAAQSFQRLMDTVLQDLDCAFVYLDDILVASSSAQSHFDDLNAVFQRLRHHGLVIKLEKCLFGVSSLDFLGHQVSSAGSVPLPSRIPVLNLSKYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TDB0</accession>
    <name>A0A433TDB0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_012650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000442">
        <property type="protein sequence ID" value="RUS79579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TDB0"/>
    <dbReference type="OrthoDB" id="6102198at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS79579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="397" mass="42430" checksum="574D79C667588659" modified="2019-05-08" version="1">MATTPSGPAVPPPDLQLHLVTDYDDMEDNSGAGSRRPSTASLSSSTVSRWIYLLLILATQLLLTSAYCLISTFAARFLVTEEPSFSRTNDPALCFSPCPIPPPPHTQALPFIKLGDVELLNIQASQPMERNCPYRFRSCPHLAALNTSQDSPSNDMAPMTDMEGNILHTSPAIRNSLYVDQPSMAELGGGIRSAANTPTPPSTPGSRRRVYGGVGGGGGGGGGGGGDPMTASFTSRSASAVHSNGGSPCSTPKLQRRFRLDQEGRTFSADAGASTDPFGFPSRDDSCCWHQPALTDCGSSRGDGNGNTISRGISQNNFDDFPDHGLEDDRVSMTDDGSSMHVCGRLSHREHHHRQLGFYQPGAPDDSADKCSRWLQSLKLSKTDKVKSRSHIQLPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TEX6</accession>
    <name>A0A433TEX6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EGW08_012147</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">EC2010</strain>
            <tissue evidence="16">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000411">
        <property type="protein sequence ID" value="RUS80101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TEX6"/>
    <dbReference type="STRING" id="188477.A0A433TEX6"/>
    <dbReference type="OrthoDB" id="196264at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098719">
        <property type="term" value="P:sodium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF191">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0050">Antiport</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018988595" description="Sodium/hydrogen exchanger" evidence="14">
        <location>
            <begin position="18"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="552"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="609"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="642"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="674"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="709"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="736"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="15">
        <location>
            <begin position="367"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="297"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="859"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="297"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="884"/>
            <end position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RUS80101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="899" mass="99890" checksum="E5F01D8E42D11FB8" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TF19</accession>
    <name>A0A433TF19_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_012085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000408">
        <property type="protein sequence ID" value="RUS80162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TF19"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS80162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="243" mass="26440" checksum="087C0EF1629FCD11" modified="2019-05-08" version="1">MNRFEPLTSCFKSQERCWLACTGSCKNPLGVNVHGVMGNSDLRSIVTGVLMCMVSTILHSKTFVHTKLGLGPEGALRVMTEGNPADWSPGKSRLGTTDSLWRCCANIRGTLAARAVQAWLSVTPLGSPGGSYTARKQPVLDLTDFDGREKFTLRGMLKGNVAAKGPKPGGEALSAQSLVPSIHWAGEFTDNEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDNNNNDNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TFN8</accession>
    <name>A0A433TFN8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_011867</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">General regulator of phagocytosis. Required to uptake Gram negative bacterium by macrophages.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000395">
        <property type="protein sequence ID" value="RUS80370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TFN8"/>
    <dbReference type="STRING" id="188477.A0A433TFN8"/>
    <dbReference type="OrthoDB" id="5960253at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010876">
        <property type="entry name" value="C1orf43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21425">
        <property type="entry name" value="NICE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21425:SF2">
        <property type="entry name" value="PROTEIN C1ORF43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07406">
        <property type="entry name" value="NICE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="244"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS80370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="276" mass="30829" checksum="239C4FE11E53756D" modified="2019-05-08" version="1">MALAKDISLVSVVLFIASGMLVFLLAFLFAKRQIMRFALKSARRPHVNIGSDAPLLLRNKIHQCLEMTQSICYEPTLLSEDVQNAANSNENHYYYRMKALDAFSNAVTTLQWSDSSVPRREPKQTIQLYLYCLCPSAAGSKGATTIEKFALCYTQARHSPAIFGEQEFIRYMELLDKVIRLIKLDQKRRSKSLRTVDMEVHFNKNALGGAETVLHERSAEHIPMQEMVRNRLGAGAGEGAEALHTTRDISSGYSSTDRSSSPGSAEKLLITDPKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TGR5</accession>
    <name>A0A433TGR5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Leucine-, glutamate- and lysine-rich protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_011457</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000373">
        <property type="protein sequence ID" value="RUS80787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TGR5"/>
    <dbReference type="STRING" id="188477.A0A433TGR5"/>
    <dbReference type="OrthoDB" id="10256467at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038799">
        <property type="entry name" value="LEKR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34251:SF1">
        <property type="entry name" value="LEUCINE, GLUTAMATE AND LYSINE RICH 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34251">
        <property type="entry name" value="LEUCINE-, GLUTAMATE- AND LYSINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="43"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS80787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="458" mass="53155" checksum="30B9A30386D63923" modified="2019-05-08" version="1" fragment="single">RNLREMTLHYTPQHPLPEEIKKLARDDTVCKYCGVSYLIHNEIKVLEDKLAKLEKELATLRGQEQREALLKKENALLKDQRNDLQASLETEHNLGKFMKALREFSALSQVVRQQKQTLEQVRNQVTESREEILGCMNEAKKNVTQLAQAATNEHEELQSRVQCLDMEKLVLSQSNATLTSNLQAAEQKLAEKERELEAERDSIRKLEKYMQDSESLSESLKDAQKSLQNSQKELEVSQEKSKTYEKELEQIKVQLRSKTSEVKESGDKMNQLQKSHEVATQKELMIEAHQNRIEELRESFKNKMAEMDNWPQKLQAAVAAEKSRHQAEMKALEENLKHNFVLELQIEKDKYNELLKKFQTQEREKNNMRQSEQAQLEQKFRQEMEDLRRQVSESKARAQEREEELQAEIASLKKIINDLQNRLARLDSEGSGEATQLKVALAEVQQELLDAQAGTAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433THD7</accession>
    <name>A0A433THD7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_011249</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000362">
        <property type="protein sequence ID" value="RUS80974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433THD7"/>
    <dbReference type="STRING" id="188477.A0A433THD7"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033344">
        <property type="term" value="P:cholesterol efflux"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042632">
        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF113">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="469"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="513"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="543"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="576"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="658"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="83"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS80974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="689" mass="77121" checksum="71FF85115E605F4F" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433THW8</accession>
    <name>A0A433THW8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_011105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000354">
        <property type="protein sequence ID" value="RUS81119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433THW8"/>
    <dbReference type="OrthoDB" id="10581367at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS81119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="285" mass="31719" checksum="DFE3D4AF3823A1B9" modified="2019-05-08" version="1">MLSSDSCKNLGDARCLPETQLDASVSTDDIDLDLDIDIDAGAPPCLDLVPDETDPKSPIPNGSTCPDQGLKQFNSLPIAKKVIVQQPVARHRFSFQSSDGGDRFATFRPSISDISPMYRYKFSHEEFEEDGASDESLSTSTVVSDYTRRASYIHNIEDDLVIIDGQIAAKDSNVDPILCRLKRQQVVAGMRRKESSVATEMLEAEKVRFDRQIDIKHIEEEDWGEAMTSFLHRCFCCDCCHSRPPVPSMRQLTPEESILSSAKRAFGSGSSWRSDSNSKRKSSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TIA6</accession>
    <name>A0A433TIA6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Receptor ligand binding region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_010957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000346">
        <property type="protein sequence ID" value="RUS81283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TIA6"/>
    <dbReference type="OrthoDB" id="188124at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019258311" description="Receptor ligand binding region domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS81283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="54286" checksum="E9BF737774E530DE" modified="2019-05-08" version="1">MAAGRSALGAILVFLCLVMETGAASVTVIKPIRTTGQEIGLIFFKDISVPGTYYNQTARAIQNASDFRVWAALIDDYKYGIKTRERMPFYIHLATLELSAAGMASGVYVGVAHGWAAHYIRRHVGDRFGIRALILLGATMNPLQLLHKSKVPVLTLAAELDGVFRISMLAKEYEEVATDNSRLFKGIYRTPVICIEGANHYQLGIGTDWTEINEGKDLRPEITDEQARSLIAKHSHDFLTVTFGTSNQNRIASLKELADSFLKSAAKFQPFIDMKNLDMSTDQKKSTWTILAQKLVAKEYIDRVTVSNEQVGNPWFFMKKPGVTANGTLVNLETFSLVHIPYISDGDYDTGLQPEGPQEVNMKLVANEAIGKAFSGKNNTALISEPVSCKSLNRYALYLALAMSSEEARDRYISRGRRIIFEEDRLVLGNVLWAPMSFQTWEDEAGLHVKSVGVINKDQHYCKVLSLLRAMEWVNIDSLRVFPTDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TJC7</accession>
    <name>A0A433TJC7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Metalloendopeptidase</fullName>
            <ecNumber evidence="12">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">EGW08_010628</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">EC2010</strain>
            <tissue evidence="18">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11 12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="12"/>
    <dbReference type="EMBL" id="RQTK01000327">
        <property type="protein sequence ID" value="RUS81615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TJC7"/>
    <dbReference type="OrthoDB" id="6131366at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.20.10">
        <property type="entry name" value="Plasminogen Kringle 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031569">
        <property type="entry name" value="ApeC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000001">
        <property type="entry name" value="Kringle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038178">
        <property type="entry name" value="Kringle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16977">
        <property type="entry name" value="ApeC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00051">
        <property type="entry name" value="Kringle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00130">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50070">
        <property type="entry name" value="KRINGLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 9" id="KW-0420">Kringle</keyword>
    <keyword evidence="3 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11 12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 11 12" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0768">Sushi</keyword>
    <keyword evidence="6 11 12" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018809068" description="Metalloendopeptidase" evidence="12">
        <location>
            <begin position="27"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="17">
        <location>
            <begin position="112"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="13">
        <location>
            <begin position="576"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="Kringle" evidence="15">
        <location>
            <begin position="691"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="16">
        <location>
            <begin position="815"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="14">
        <location>
            <begin position="882"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="14">
        <location>
            <begin position="1111"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RUS81615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1233" mass="136977" checksum="B00C6F8001AAEE93" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TK07</accession>
    <name>A0A433TK07_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_010282</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000313">
        <property type="protein sequence ID" value="RUS81937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TK07"/>
    <dbReference type="STRING" id="188477.A0A433TK07"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000026">
        <property type="entry name" value="Transcription factor Sp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="74"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS81937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="121" mass="13825" checksum="184EBD4D4163FC2B" modified="2019-05-08" version="1" fragment="single">FACSWLFCGKRFTRSDELQRHKRTHTGEKKFQCPECNKRFMRSDHLTKHIRTHNAKRQYLGDGVSSTQGLEMDVHAMGEEEEEDDDEEEEGGDSDTKVFHVSLSEEEVEEDTQGSSGGGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TK33</accession>
    <name>A0A433TK33_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">REJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_010272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000312">
        <property type="protein sequence ID" value="RUS81957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TK33"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS81957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="14443" checksum="77A2A94EC47186E6" modified="2019-05-08" version="1" fragment="single">AHTLTHSLYQALTRPPSCSLSHSLPISLTVFAYSFTHSQSLTSFTHSLSFTYSLFFTHSLSFTYSLSFTHSLSFTYSLSFTHSLSFTHSLSFTHSLSFTYSLSFTLSLFSLTLFYSLTHSYTHSLSIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TKU0</accession>
    <name>A0A433TKU0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_010056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000299">
        <property type="protein sequence ID" value="RUS82174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TKU0"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS82174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="331" mass="35140" checksum="FF8214DB45CECE40" modified="2019-05-08" version="1">MSVRSPESATIMHAVPFLAHFELRGCILRGWQRVYIVVELFTVDLCLCVPVRPPPIGARGFTWIDNTVRARPSQLYSCARQIQALDRLECCSNNRGGGDVGGGDDGRGGDVGGGVDGSGGGDGYDDNSDPGAKCRQPFVITGTTNQKIFLAKQTNMVKTSRLTTQSKELRTQTEIKAYRQVGGEYASVHHWTGEHTGSPSGGENASINHWSGEHTGSPSGGENASSTIGPVNTLVHPVGENMPQSTIGPVNTLVHPVGEKMPQSTIGPVNTLVHPVGEKMPQSTIGPVNTLVHPVGEKMPQSTIGPVNTLVHPVNHWTGAHTGSPSQPLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TLH8</accession>
    <name>A0A433TLH8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane protein 188</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_009799</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CNEP1R1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000286">
        <property type="protein sequence ID" value="RUS82453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TLH8"/>
    <dbReference type="STRING" id="188477.A0A433TLH8"/>
    <dbReference type="OrthoDB" id="5786980at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071595">
        <property type="term" value="C:Nem1-Spo7 phosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019168">
        <property type="entry name" value="NEP1-R1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20996">
        <property type="entry name" value="NUCLEAR ENVELOPE PHOSPHATASE-REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20996:SF1">
        <property type="entry name" value="NUCLEAR ENVELOPE PHOSPHATASE-REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09771">
        <property type="entry name" value="Tmemb_18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS82453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="122" mass="13924" checksum="C3247508C8E9A9CD" modified="2019-05-08" version="1">MADQTEDLKAFERRLTEVISGHQPAARFWRIIFILVSLCTVVGAWTWLRDPETTQVSLSQSLWNHLFFTVSCSILLLLFLFGIHKRIVAASIIASRCRTFLAEYNMSCDDNGKLILKPRPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TM70</accession>
    <name>A0A433TM70_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_009524</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000275">
        <property type="protein sequence ID" value="RUS82687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TM70"/>
    <dbReference type="STRING" id="188477.A0A433TM70"/>
    <dbReference type="OrthoDB" id="268693at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00513">
        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_eL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018263">
        <property type="entry name" value="Ribosomal_eL32_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_eL32_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L32 AND DNA-DIRECTED RNA POLYMERASE II, SUBUNIT N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="Ribosomal protein L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00580">
        <property type="entry name" value="RIBOSOMAL_L32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS82687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="134" mass="15931" checksum="E6AE61C5B299D9C0" modified="2019-05-08" version="1">MAIRPLVKANIVKKRTKKFIRHQSDRYGKVKSNWRRPKGIDNRVRRRFKGQYKMPNIGYGTWKNCKHVCPDGFKKFLVHNVRELEVLMMQNRTYAAEIAHNVSSKKRKEIVERAQRLAIKVTNPNARLRSKEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TP32</accession>
    <name>A0A433TP32_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_008889</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000247">
        <property type="protein sequence ID" value="RUS83342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TP32"/>
    <dbReference type="STRING" id="188477.A0A433TP32"/>
    <dbReference type="OrthoDB" id="639027at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="96"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="186"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="573"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="801"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="990"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="596"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="624"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="642"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="668"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="803"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="990"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="1009"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1039"/>
            <end position="1066"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS83342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1116" mass="115006" checksum="27CB781C6BD592C1" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TRY7</accession>
    <name>A0A433TRY7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycogen [starch] synthase</fullName>
            <ecNumber evidence="8">2.4.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_007918</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18549"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:18550"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.11" evidence="8"/>
    <dbReference type="EMBL" id="RQTK01000209">
        <property type="protein sequence ID" value="RUS84324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TRY7"/>
    <dbReference type="STRING" id="188477.A0A433TRY7"/>
    <dbReference type="OrthoDB" id="6335297at2759"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03793">
        <property type="entry name" value="GT3_GSY2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000014">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000028">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008631">
        <property type="entry name" value="Glycogen_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176:SF3">
        <property type="entry name" value="GLYCOGEN [STARCH] SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176">
        <property type="entry name" value="GLYCOGEN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05693">
        <property type="entry name" value="Glycogen_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="636"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="664"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS84324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="702" mass="80780" checksum="8D7D9FF785A1EAB5" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TS21</accession>
    <name>A0A433TS21_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_007952</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000210">
        <property type="protein sequence ID" value="RUS84308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TS21"/>
    <dbReference type="STRING" id="188477.A0A433TS21"/>
    <dbReference type="OrthoDB" id="6126859at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="56"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS84308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="364" mass="40527" checksum="651C491C41003E14" modified="2019-05-08" version="1">MDHQVSTNCSDSETNQTISGFENQNAFDQLLERIFLLDAPGLSWTIFLFGIVAIVGNILTILVYARLGFAQTINMSYVALAVSDLFSVLTAMTGAFCFTPAMGAILQQLRVRVDLANLAAFVGDWPHFAFSKTTAILTAWVSVERCLCVLIPTRVRLIINRRVTKTVVSALFVLGCCPLVFAYIGMKTDWEFDAETNTTTLNIFYSFKKANNVYNSIAVLLYGAVYPTLSWVIVTTCTTFLIIKLRESARWRKSNSNGVNPNVPTGTTQKNGHKGENRITKTVVMIACVFITCSLPRSVHSLVSLAFRHKYSTYGDLRPLFVMNAGFALLLSEINSGTNIILYSITSRKFRSTLKEMVFNKFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TS73</accession>
    <name>A0A433TS73_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Granulins domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_007843</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the scorpion calcin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000207">
        <property type="protein sequence ID" value="RUS84381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TS73"/>
    <dbReference type="OrthoDB" id="6122430at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019855">
        <property type="term" value="F:calcium channel inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012632">
        <property type="entry name" value="Scorpion_calcine"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60028">
        <property type="entry name" value="SCORPION_CALCINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0108">Calcium channel impairing toxin</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0872">Ion channel impairing toxin</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1219">Ryanodine-sensitive calcium-release channel impairing toxin</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0800">Toxin</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019314803" description="Granulins domain-containing protein" evidence="8">
        <location>
            <begin position="25"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS84381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="156" mass="17486" checksum="3E920148B2C91D28" modified="2019-05-08" version="1">MNCERGIAIVTLVLVVCVGHTCLGFNCKFPNEGCERDEDCCSRKCVDAHPGTNARCTKLGLHKPCLYTYQCEDRLRCGNNSCCAKYWGICKHARDCCDKTHHCYEVDDFYYKRCLMAPSLGIALSSCLQVHFYIVCFLVASLATLAPSYMCGTRSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TTJ7</accession>
    <name>A0A433TTJ7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Strictosidine synthase conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_007351</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the strictosidine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000190">
        <property type="protein sequence ID" value="RUS84882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TTJ7"/>
    <dbReference type="STRING" id="188477.A0A433TTJ7"/>
    <dbReference type="OrthoDB" id="5307922at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018119">
        <property type="entry name" value="Strictosidine_synth_cons-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10426:SF20">
        <property type="entry name" value="ADIPOCYTE PLASMA MEMBRANE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10426">
        <property type="entry name" value="STRICTOSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20067">
        <property type="entry name" value="SSL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03088">
        <property type="entry name" value="Str_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Strictosidine synthase conserved region" evidence="4">
        <location>
            <begin position="171"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS84882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="393" mass="43159" checksum="8E82C34CAAA94852" modified="2019-05-08" version="1">MQGELVKRVWSKPVLVAFTAVLTIYLIPSPISPKPVRLSDHLPVLEGPLAANRNLQKVTKLFEGQILGPESFAAGHDGSIYTGSADGRIWRIKDNTLSYVARTGLDHPDCGTYALEPECGRPKGMKLDARGDLIVVDAYKGLLRVDLDSGRVETLLDSELGFNGSKFLFLNAMDILNNGTILISESSTKWERRDYRYEVIETNNLGRILAFDPETRKAWLVADELYLANGMTLTHDQSAILVAEMSLSRISKIFVTGSRAGERSVLVSNLPGYPDNIKQNSRGHYYVGLGSVRFVGSSPLGSFLDLVGPYPALKKIITKLVPAAMFDVFLPKHAILLEISDDGSIVTSHHDPGASTLPALSEAFQHGEDIYIGHFKIPFVGRVKNSDLHNEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TVY7</accession>
    <name>A0A433TVY7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_006503</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000161">
        <property type="protein sequence ID" value="RUS85709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TVY7"/>
    <dbReference type="OrthoDB" id="6091802at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="48"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS85709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="337" mass="38012" checksum="CD74DD40E17AEBC9" modified="2019-05-08" version="1">MDNLTRDAFTRGVANHTEPWAPLLSDAALDLFSFVMFMIISCPSCCLGIVTNIANIVVYTKMGFSESSNVNFLALSVFDFLASVTILAMRTLYIPYFKGLANAALARYISHCLSHAIYVVIGGSAMMTALIAVERCICVVFPIKVKTWLTRRRSLYLMLTVVAYHLAFLVLIYSDPGPPYDAHPKKIAFYYVALYSIPSTTCFFVVVVSTIFLVVHLRRNQRWRKQTSSRSVKTSDKEERLVKTIIAISIIFIICSFGNVSIFIASILYPPFQYSNPYFANLVLAFFGVSLNFQTVSACLNFFFYYRMSSRFKRVFHTRFAPCRTGKSDASISGTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TWF4</accession>
    <name>A0A433TWF4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DOMON domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_006349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000157">
        <property type="protein sequence ID" value="RUS85865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TWF4"/>
    <dbReference type="OrthoDB" id="6178696at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019239064" description="DOMON domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS85865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="22219" checksum="9CDA13A56CED43A2" modified="2019-05-08" version="1">MLVPTTATILMMCVSSLLHTTHGQVCQPPQSESVYFLTSTLEDLYVATDYSQGKTLVVFGDGPQGDTWFLVDTVSRNTYYSNPEDGCVYAQFSPEQNELVSQIWSQCLPSDAELERSGDVDFYHMERPGFDWLVGMKPVPDTDYFYKHFSRINSYGVYKVPDESSFGLVYQYSVGLSDPSVFDRDLSACVEGPHNMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U1I9</accession>
    <name>A0A433U1I9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_004588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000104">
        <property type="protein sequence ID" value="RUS87665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U1I9"/>
    <dbReference type="OrthoDB" id="5990578at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009301">
        <property type="term" value="P:snRNA transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021281">
        <property type="entry name" value="SNAPC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15132">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15132:SF1">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="1">
        <location>
            <begin position="70"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS87665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="372" mass="41887" checksum="165F636734105A1A" modified="2019-05-08" version="1">MFKYLKNFGEKNPPHSKLLLVVSRIRKANMSTSTQKRALRNRAVMREKWNEAYRAPIKKGRPQKNPPRGKREAWTIVEKKCLLEGLKSYGPQNLKLIANLIGSKSEAEVQEKIFSLRGAAACDIQSTNGANNEERTSIEKWIFSLGELVRCDDIDCSLEISKALGYIAKYENFDDNQVSDLSWRNIYLYLSGLAENRTVGLPRMSDTESVILLELLTELGTSLNKMDTFPQQQILEHKIQMINAGACVQFLNRAQRTQNTLLLSQALGNEFTGLENQLVDSISGTSTSSNPSISKTSESTCSLDDVETASHSKAAYSVNPSNLVYKNEVNLNEYVGLKYSDELDKIFIKPKLFTFNPLCIPTKLLNFKLKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U5G7</accession>
    <name>A0A433U5G7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_003164</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000067">
        <property type="protein sequence ID" value="RUS89053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U5G7"/>
    <dbReference type="STRING" id="188477.A0A433U5G7"/>
    <dbReference type="OrthoDB" id="2218807at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097149">
        <property type="term" value="C:centralspindlin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20821">
        <property type="entry name" value="C1_MgcRacGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04382">
        <property type="entry name" value="RhoGAP_MgcRacGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000033">
        <property type="entry name" value="Rac GTPase-activating protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46199">
        <property type="entry name" value="RAC GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46199:SF3">
        <property type="entry name" value="RAC GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0744">Spermatogenesis</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="9">
        <location>
            <begin position="15"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="10">
        <location>
            <begin position="75"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS89053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="38322" checksum="E86D5DB31243E2D3" modified="2019-05-08" version="1" fragment="single">ALRKASSAGRGLNRVHIFISKTVIKPETCVPCGKRVRFSKPALKCKECRAVCHPECRDKLPLPCIPSCPSTPGTNKLSEGIISDFAPSERPMIPRLVVNCANEIENRGLSEVGIYRVPGSDKEQKELKEKFLKGRHPHLSNIHDIHVVCGCLKDFLRGLKEPLVTFHLWPSFVDAADIGDRNKCREELQHLVQSLPQANMDTLAFLVQHLQMIAETPACKMPAGNLAKVFGPTIVGYSCPDPAPMQIMTETRRQNQVMERLLEIPRDFWADLLCVDDMSLFPGGTPYTPDFHSAPRSMLGPINTPDMTEYANEMTRTATTPKYSTKTFHSKKPSRFFSSPVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U7A7</accession>
    <name>A0A433U7A7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Suppressor of cytokine signaling 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_002595</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000050">
        <property type="protein sequence ID" value="RUS89674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U7A7"/>
    <dbReference type="STRING" id="188477.A0A433U7A7"/>
    <dbReference type="OrthoDB" id="5979828at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005942">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046935">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000028">
        <property type="entry name" value="Suppressor of cytokine signaling 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10155">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10155:SF0">
        <property type="entry name" value="SUPPRESSOR OF CYTOKINE SIGNALING AT 36E, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00253">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="3" id="KW-0734">Signal transduction inhibitor</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SH2" evidence="8">
        <location>
            <begin position="365"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="9">
        <location>
            <begin position="455"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="129"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="184"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="193"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS89674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="522" mass="59264" checksum="664FB5EBF9391752" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U7M5</accession>
    <name>A0A433U7M5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">40S ribosomal protein S9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_002419</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000047">
        <property type="protein sequence ID" value="RUS89807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U7M5"/>
    <dbReference type="STRING" id="188477.A0A433U7M5"/>
    <dbReference type="OrthoDB" id="1697570at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000021">
        <property type="entry name" value="40S ribosomal protein S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_uS4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005710">
        <property type="entry name" value="Ribosomal_uS4_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003139">
        <property type="entry name" value="PRK04051.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01018">
        <property type="entry name" value="uS4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF5">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 9" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="13">
        <location>
            <begin position="7"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="12">
        <location>
            <begin position="108"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS89807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="191" mass="22267" checksum="31E040E998C87758" modified="2019-05-08" version="1">MPSKIPNIQGKTYTTPRRPFEKERLDQELKLIGEYGLRNKREVWRVKYALGKIRKAARELLTLDEKDPKRLFEGNALLRRLVRIGVLDESKMKLDYVLGLRQEDFLERRLQTQVFKLGLAKSIHHARVLIRQRHIRVRKQVVNIPSYVVRLDSQKHIDFSLRSPYGGGRAGRVKRKNAKKGQSGGDEEADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U932</accession>
    <name>A0A433U932_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_001896</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="RQTK01000035">
        <property type="protein sequence ID" value="RUS90298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U932"/>
    <dbReference type="STRING" id="188477.A0A433U932"/>
    <dbReference type="OrthoDB" id="1738954at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000315">
        <property type="entry name" value="Calcium-dependent protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.230">
        <property type="entry name" value="Doublecortin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003533">
        <property type="entry name" value="Doublecortin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036572">
        <property type="entry name" value="Doublecortin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03607">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00537">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89837">
        <property type="entry name" value="Doublecortin (DC)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50309">
        <property type="entry name" value="DC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Doublecortin" evidence="13">
        <location>
            <begin position="3"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="390"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="116"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="670"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="166"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="293"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="348"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="362"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="677"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS90298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="695" mass="79728" checksum="8FCE544B90F15B80" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UAL7</accession>
    <name>A0A433UAL7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Wiskott-Aldrich syndrome protein family member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_001348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000023">
        <property type="protein sequence ID" value="RUS90841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UAL7"/>
    <dbReference type="STRING" id="188477.A0A433UAL7"/>
    <dbReference type="OrthoDB" id="1060785at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23039:SF9">
        <property type="entry name" value="LOW QUALITY PROTEIN: NHS-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23039">
        <property type="entry name" value="NANCE-HORAN SYNDROME PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS90841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="26535" checksum="998FE6C66E68665C" modified="2019-05-08" version="1">MPLADRTVLPSCLGRRAIAEEDRTEENSLVAVSHNAVLGCIIQLASLVRHADDIFCDLAEECQLVFEKSEAIHLKVHGLARRIEQLDFTEVNIPMPLADRTVLPSCLGRRAIAEEDRTEENSLVAVSHNAVLGCIIQLASLVRHADDIFCDLAEECQLVFEKSEAIHLKVHGLARRIEQLDSTEVNIRMPPVREQNRTYSMLNLTAPTSLTPSLSVYSANLNKARAIETRGIHKSGLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UDG0</accession>
    <name>A0A433UDG0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sorbitol dehydrogenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Polyol dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_000363</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000005">
        <property type="protein sequence ID" value="RUS91792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UDG0"/>
    <dbReference type="STRING" id="188477.A0A433UDG0"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="9">
        <location>
            <begin position="11"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS91792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="371" mass="39640" checksum="64F02D184A3EEA8D" modified="2019-05-08" version="1">MSTNRAVRIHGKNDIRIENLPIPEPQENWVQLRMSSVGLCRTDVHLFDEGRVDHIVIDKPITIGHEISGTVSKLGSGVTSLAVGDRVAVDPCRACGDCHQCCRGRPNICRQLHCCGVLHADGGFATYMVTPAKTCYKLPDHVSLEEGAMMEPLSVGVNGVRRAGMVDGDVVVVIGAGPIGLFAMQVAKALGASRVMMVGKSMLKTNSFKALLEHDFSYTDINPKRLELALQMGVDQVLKPTVGLSDPKAASEELKAALGDEADLCIECSGAPGVVDLAIHACRPGGKVLMLGFGDMAMNVHLGMAAVREIDVIGSFANLHNYPECIRLVSEGKIDVRSAITHRLPLENVMEGINLVRSGESVKVVINCGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z3P8</accession>
    <name>A0A3S0Z3P8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_023601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01002167">
        <property type="protein sequence ID" value="RUS68638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z3P8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS68638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="348" mass="44974" checksum="6D0D3D09DBEE9608" modified="2019-04-10" version="1" fragment="single">KKKKKKKKKKKKKKKKKKKKKKKKKKKKQEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEDDEEYFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZAM8</accession>
    <name>A0A3S0ZAM8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Galectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_021671</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001380">
        <property type="protein sequence ID" value="RUS70572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZAM8"/>
    <dbReference type="STRING" id="188477.A0A3S0ZAM8"/>
    <dbReference type="OrthoDB" id="6147920at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00070">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044156">
        <property type="entry name" value="Galectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346:SF147">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00908">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00276">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0430">Lectin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Galectin" evidence="3">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU102079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS70572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="131" mass="14598" checksum="F63D530CDF1A9DFC" modified="2019-04-10" version="1" fragment="single">FSINLCVGSDYNEDTPLHFNPRFDNQEVVRNSSSGGGWGDEEKEGGFPFTQGAPYDVKIAVMESHYEISVNGSHFCNYNHRQPFQSVRNVYIEGATTANWVVSQFLYQVPFPISDGVEIIVHGVATGSAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZCF4</accession>
    <name>A0A3S0ZCF4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_016539</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000718">
        <property type="protein sequence ID" value="RUS75697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZCF4"/>
    <dbReference type="STRING" id="188477.A0A3S0ZCF4"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052603">
        <property type="entry name" value="EFCB6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20875">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20875:SF0">
        <property type="entry name" value="GH12158P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="84"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="120"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS75697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="152" mass="17637" checksum="CC85D84851011976" modified="2019-04-10" version="1">MYKMKLPLSGPQRTELCNLFDLRANGWFHYISFLQAIKKHTPGEHISPCVFDIHTKRLHRKAGPTSQALTVFDFLLELKTLLLKKHKTLRSSFKIFDLNRSGYVEETELRTSLGQLGYALSDQDFLDILQVFDRSQAQRVSFDDFKTTLLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZCR3</accession>
    <name>A0A3S0ZCR3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_017507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000804">
        <property type="protein sequence ID" value="RUS74733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZCR3"/>
    <dbReference type="STRING" id="188477.A0A3S0ZCR3"/>
    <dbReference type="OrthoDB" id="6923473at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="121"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="309"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="432"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS74733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="573" mass="66757" checksum="FEB1C72FFBBD8201" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZEG6</accession>
    <name>A0A3S0ZEG6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SFR19-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_015189</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000614">
        <property type="protein sequence ID" value="RUS77052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1935339at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047157">
        <property type="entry name" value="PHRF1/Atg35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057031">
        <property type="entry name" value="SFR19-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12618">
        <property type="entry name" value="PHD AND RING FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12618:SF20">
        <property type="entry name" value="PHD AND RING FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23030">
        <property type="entry name" value="SCAF11-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SFR19-like C-terminal" evidence="2">
        <location>
            <begin position="1320"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1202"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1276"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1396"/>
            <end position="1444"/>
        </location>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF23030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS77052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1444" mass="162052" checksum="4CA3F829F97615D5" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZH01</accession>
    <name>A0A3S0ZH01_ELYCH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">EGW08_013527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
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            <taxon>Placobranchoidea</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    <dbReference type="Pfam" id="PF14769">
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="RUS78706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="370" mass="41771" checksum="7B8757149751A17C" modified="2019-04-10" version="1">MSMALSPLSADGSGSNRRLSKVSDVSLGVDNPSKTSRRLSKVSDMSLGNSNSGTPRGGTERLSFSVPSPRGGSENVASLIKDSKSNDVFRIFTHKPKLKDFVRAEQPMERFFPKRHKAKVIVWADLTVDAVDRLNESLNADHVKQVLADIFELDNYKDNLRTGIKMDLFYYTLQFAREQQFSSEKISAFFSIMKRIFEVCIETPYGNLDHTFQYFKDLLLCHSVNRPPYSIELFNPHEVRKITEYAINTFFRHFKMYKYAFTPKVRLDLAINYVGMPPSPPSSESDLKGAEGGKMEDESADGGDQAEEIDEERLAAREELRGMVKDFLNKESKRIEGSVEQHLKAAVSSLNTQIDGMIEATVPDKGKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
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    <name>A0A3S0ZPJ1_ELYCH</name>
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        <recommendedName>
            <fullName evidence="2">ISXO2-like transposase domain-containing protein</fullName>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="IS1016-like_transposase"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163:SF2">
        <property type="entry name" value="SI:DKEY-17M8.2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS82738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="227" mass="26047" checksum="B45CB806428C1381" modified="2019-04-10" version="1">MSSRSNTRRSNESNTEGEQKQEDAQEKHASIKNLAREYPMATEAIVNWRNYIRDVFAEYFIANPLAIGGPGHVVEIDESAFVKRKCNVGRAVRTQWVFGCIDVESKHGFLVAVPQRDAATLLPILQQYVLPGTTVVSDLWGAYNTINNLGYHHLTVNHSLHFVDPATHATTNHVESMWSRAKLRNRRECGTHRQLLDSYLIEFMWRLQFNGDPFENLLTHIRNLYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZQG7</accession>
    <name>A0A3S0ZQG7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_019327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001001">
        <property type="protein sequence ID" value="RUS72907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZQG7"/>
    <dbReference type="OrthoDB" id="10683779at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="411"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS72907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="475" mass="48896" checksum="56F2DCC1CEB62166" modified="2019-04-10" version="1" fragment="single">FTSSDKHNENATSKKHLGQCDPKNIHDDKSNKVNHLKHLYASKDLSVPYENLIPVTDSDKCIATMNGEQSSTFTGEASSNPPTRSVVKNAGAPAEASSSSPTMCNKTSGAGESHEQHGQTGPTTVAPSRRSDPSGRKKSRKAARPRRQPALSQLALEQDVSDSEPVLGLEGPSSGNTGGGPGWGKPQPSNPRARSSTPDSFDPSSGNNGPRAVSLGLINEEAVATVTTDTERIDPGNKESESRLERENAGASISNNNNNNNNNNNNNNSSSSGGESSTECKGLVDFAHNTMQELLGIYGLGEGDARDSRDSGLSIQGLKSCFRGEAGPGMASPALTSASSSAGGRDRGGQSPRPGAGAGVGSGGAACKSRPFRKNVYTSLMHHAVESAVPSPLALKPVPDSLSREHFQLMDASSASNSNDSSTTTTSTTSTATTASTAAAAPSPFGVALPGRVLAGAEGAKKTYVQKPPSSKDVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZR91</accession>
    <name>A0A3S0ZR91_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ferroxidase</fullName>
            <ecNumber evidence="1">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_008277</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="1"/>
    <dbReference type="EMBL" id="RQTK01000223">
        <property type="protein sequence ID" value="RUS83971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZR91"/>
    <dbReference type="STRING" id="188477.A0A3S0ZR91"/>
    <dbReference type="OrthoDB" id="186462at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001519">
        <property type="entry name" value="Ferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431">
        <property type="entry name" value="FERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431:SF75">
        <property type="entry name" value="FERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="128"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="196"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS83971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="322" mass="37445" checksum="4DD1169601E16DD9" modified="2019-04-10" version="1" fragment="single">DIVRQGYNERLNFQLEQQITSYVRQEVAYKAYASYFGRADVARDGFQHFFHDSAKTARKLGLELTQLVNQRGGHVRYPVIQLKDACTHAIEAELAKGEITKPRFGQPGSARTEDLICQFLLLNRKDTSHQDKADRQDTRDRPERRDRWDKSDKTDETDKTDTDKLLKNKITGESRPSRVRLARIKRWTWSLFASDREDQEDQADQGDQATTTITVQSETSSQAPSAYKLDDRSSWLNGLFGLEDCLAVEKTAQQELLPIIAMTRKGNMRDPQIYHALRFNLDHHVMRTYRVAELVTRLQRQQDLDSYELEEFLLDKELEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZRK7</accession>
    <name>A0A3S0ZRK7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ZSWIM3 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_011127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000355">
        <property type="protein sequence ID" value="RUS81087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZRK7"/>
    <dbReference type="STRING" id="188477.A0A3S0ZRK7"/>
    <dbReference type="OrthoDB" id="6105425at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048325">
        <property type="entry name" value="ZSWIM3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040854">
        <property type="entry name" value="ZSWIM9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47086">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47086:SF4">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21599">
        <property type="entry name" value="ZSWIM3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZSWIM3 N-terminal" evidence="2">
        <location>
            <begin position="65"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS81087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="449" mass="52075" checksum="252F038807A7D77E" modified="2019-04-10" version="1">MSAQEQDEIDPTEEAETAEGSDLANENEDGEGYANYKDLKEEINHSLADTVDTTAEFLQIFQGKTEFKSWEEFHTLFEKFQKDTGSAFKPKSVTSIEYANERRVRDAIPDHFVYQTVKMVCTHYGVPNPVKKEGLKPRKKYVGRGCEAMVHLRYKGGTLNIVGCNLEHKNHPLFSGTDVIRSVRSFSFSDDIDLLMAKVVMEHNPFANWTSEKEWMALVADLQCRDSRLKTVTVRVVKKRIRFLIDRYMSNSNGKAPLPDDEMGIILYELAKAKQEAADRITKIQKKRGRKRGRPRKYPKPESEDDDEEFVTDFDESFSERKPRYSSPTSSASLPGKEVAVFLGYLERKDDNDRRLKQDDLDLRRRELELHRKQFELRRERFEFERLERQAHLDLLKAQAEVLVSQRTQQQQQHLQQEQKLVYADPKGDGSGVTEYTIVVNNDQAYITQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZW51</accession>
    <name>A0A3S0ZW51_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Globin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Myoglobin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_007819</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="9">Belongs to the globin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000206">
        <property type="protein sequence ID" value="RUS84435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZW51"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47217">
        <property type="entry name" value="GLOBIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47217:SF1">
        <property type="entry name" value="GLOBIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="4 9" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="10">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS84435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="160" mass="18817" checksum="6F6E2C602AFFA371" modified="2019-04-10" version="1" fragment="single">TDRQTTYRQTDRQTETPCYPCLRVSPCIPARFFERFPQHQHYFKMFRDVPPSELRSLSVLANHGRRVMDQVQALVDNMDSPGILQEKLAWVSMKHKPRRVRVPQFQDMLHMFVDFLQQELGDERFTARHRDAWHKWLADVLALLEAAETRPDGPQGGDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZYD1</accession>
    <name>A0A3S0ZYD1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_003152</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000066">
        <property type="protein sequence ID" value="RUS89089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZYD1"/>
    <dbReference type="OrthoDB" id="6161887at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="583"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="329"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="420"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="478"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="271"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="420"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="445"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="480"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="595"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="614"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS89089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="644" mass="72197" checksum="3846D8E8C81D251F" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZYE6</accession>
    <name>A0A3S0ZYE6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">guanylate cyclase</fullName>
            <ecNumber evidence="1">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_003129</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="1"/>
    <dbReference type="EMBL" id="RQTK01000065">
        <property type="protein sequence ID" value="RUS89121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZYE6"/>
    <dbReference type="STRING" id="188477.A0A3S0ZYE6"/>
    <dbReference type="OrthoDB" id="1890790at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF501">
        <property type="entry name" value="GUANYLATE CYCLASE 32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="130"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS89121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="296" mass="32044" checksum="FEFDE48B50FD95A0" modified="2019-04-10" version="1">MADGSRDAQFMLHNLQGGCYVPIARSATTCPTSVDPSADLVTRCIVTREPADNQRISLQRQENSRAWIIHIDDLKVRGRSRSHISSSYMASRTSFSTESSLGQSFTEMYIYKGEDVAGKTIVIPMSKNQYGPASKRISSKGGAKQAEGQAAESVPSGAGGATKQTQVGIATTLSSGAAGGRPGLMITKPFTKEVNHGLRQLHHSLVGHHGRLKSSNVLVDNRWTCKLAHMMVPSLASPEYPNELDEDINFSSFLFTPPEVLRQPTLGIPGTKAADMFAYAIILMEILTAAYKTVRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZZU5</accession>
    <name>A0A3S0ZZU5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_001349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000023">
        <property type="protein sequence ID" value="RUS90842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZZU5"/>
    <dbReference type="STRING" id="188477.A0A3S0ZZU5"/>
    <dbReference type="OrthoDB" id="1060785at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024845">
        <property type="entry name" value="NHS-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15273">
        <property type="entry name" value="NHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="674"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="483"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="516"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="674"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="702"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="724"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS90842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="923" mass="101590" checksum="DDB87B011FCF8A36" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A089</accession>
    <name>A0A3S1A089_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_001743</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000031">
        <property type="protein sequence ID" value="RUS90475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A089"/>
    <dbReference type="STRING" id="188477.A0A3S1A089"/>
    <dbReference type="OrthoDB" id="2365484at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06090">
        <property type="entry name" value="KOW_RPL27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.770:FF:000001">
        <property type="entry name" value="60S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001141">
        <property type="entry name" value="Ribosomal_eL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018262">
        <property type="entry name" value="Ribosomal_eL27_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041991">
        <property type="entry name" value="Ribosomal_eL27_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038655">
        <property type="entry name" value="Ribosomal_eL27_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10497">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01777">
        <property type="entry name" value="Ribosomal_L27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01107">
        <property type="entry name" value="RIBOSOMAL_L27E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS90475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="136" mass="15854" checksum="689255526513847F" modified="2019-04-10" version="1">MGKFMKSGKVVLVLGGRFAGRKAVIVKNYDDGTPERPYGHALVAGVDRYPRKVTRSMGKKKLKQRSKVKSFVKVYNFNHLMPTRYSVDINFEKNVVNKDVFRDPALKKKATREVKAKFEDRYKTGKSKWFFQKLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A102</accession>
    <name>A0A3S1A102_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_001107</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000018">
        <property type="protein sequence ID" value="RUS91082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A102"/>
    <dbReference type="STRING" id="188477.A0A3S1A102"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF92">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="2"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="281"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS91082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="485" mass="55767" checksum="1A039BCC5FFCFE92" modified="2019-04-10" version="1">MSQIQKELGRGAFGVVYLLQLPNSAKFALKVIHQSNADEEAFKEADILSKHCHPHLVKCFSSFKIRSSVYLITEYCGQGTLKEYICKQKQYISEKTVLKMLCQLSDVLRYLHVNKIIHRDLKPANIFLDKQRSVKVGDVGVARQLDHTTEEASSLAGTLLYMCPEIRACEKYTSKADIWSLGCCVHEMMTLSKTFHSLKEMYSMDIPSMPQDVYSDRLQMLVLHMLREDPETRPDAYDILQQACEIRGKHYKSGNIHPNTEIIVEPREIYRAVSQFEEESKSSSWNTERVGASLQSQEEDSQYEQTIRNSRVTARSPREKGFQLSEEPFVKQERHNFGKHRSQISQSSQTFEELESAVSDWTTQKDFTDSSCSFTVIGSSNLRPDDENHGESLYTQSIQTLIDDDESWASDSDNTVTLYTRAQHARYKNRPKKESEYISRSHLAQSTANVFAEQSAHLRELMLRRVVGNDNYEVDGKPMLRHQPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A1D1</accession>
    <name>A0A3S1A1D1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_011995</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000403">
        <property type="protein sequence ID" value="RUS80230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A1D1"/>
    <dbReference type="STRING" id="188477.A0A3S1A1D1"/>
    <dbReference type="OrthoDB" id="6145895at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000003">
        <property type="entry name" value="Solute carrier family 17 member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF399">
        <property type="entry name" value="FI19708P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="277"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS80230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="40099" checksum="BC4321F1C607E0B8" modified="2019-04-10" version="1" fragment="single">KESVCGKYSSCRWVLAYLCFLARFMQTALRQSLGIAIIGMTMKVTERVVTPDAGLEAWEADNARNNSALHGNNNIGSSGSLAGPVFLNLVQNGSTVRWTDENGHNWTMEGLFASLPFMGRIVSGIAAAVVSDWMLRVGVSTATTRKTFQALGNWSCGLCTLLLAFIPMSAATSMGFLVLALTMQNLTSVAYKINLLDIAPRYAGLLNGVMSTVSTLASLPAPVITSLLIADGSREGWRAVFCMVAGLTTFGGLIFIVFAQGEIQDWAVMPVSSTPVDLDPEADPAPSGARSSRKRRRSGYGEMDPSDLYVPESCLFGVQSGGPVRGVQSLPPTSHGVAGSKPKQKLRRSATVEVGAFVRRVRSQAFSNLPFSDFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A291</accession>
    <name>A0A3S1A291_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Alpha-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_000211</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000003">
        <property type="protein sequence ID" value="RUS91998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A291"/>
    <dbReference type="STRING" id="188477.A0A3S1A291"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.200.10">
        <property type="entry name" value="MHCK/EF2 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004166">
        <property type="entry name" value="a-kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051852">
        <property type="entry name" value="Alpha-type_PK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45992:SF11">
        <property type="entry name" value="ALPHA-TYPE PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45992">
        <property type="entry name" value="EUKARYOTIC ELONGATION FACTOR 2 KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02816">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00811">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51158">
        <property type="entry name" value="ALPHA_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Alpha-type protein kinase" evidence="7">
        <location>
            <begin position="57"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="341"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="466"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="341"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="376"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="472"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="523"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS91998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="629" mass="69402" checksum="2BBFEFDE11E8A082" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A497</accession>
    <name>A0A3S1A497_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Synaptic plasticity regulator PANTS</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Plasticity-associated neural transcript short</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_009861</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Synaptic cleft</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0545 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000288">
        <property type="protein sequence ID" value="RUS82409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A497"/>
    <dbReference type="STRING" id="188477.A0A3S1A497"/>
    <dbReference type="OrthoDB" id="5946508at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043083">
        <property type="term" value="C:synaptic cleft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021475">
        <property type="entry name" value="Pants/Emi1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052:SF1">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11326">
        <property type="entry name" value="PANTS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS82409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="114" mass="13627" checksum="647B6800527E3161" modified="2019-04-10" version="1">MDSGLSNLPKDIWLMKPCEVYKEEHNDCKKILSRFYQYYVDGAKTDCSQWLMDFKNCMIFRKTRDTKAMDAVLSSERKRRAERLQRARDNNVWEYRTSPPPEWFSPLSSESACR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AVP1</accession>
    <name>A0A3S1AVP1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Receptor expression-enhancing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_018764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000931">
        <property type="protein sequence ID" value="RUS73484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AVP1"/>
    <dbReference type="STRING" id="188477.A0A3S1AVP1"/>
    <dbReference type="OrthoDB" id="10009287at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071782">
        <property type="term" value="C:endoplasmic reticulum tubular network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071786">
        <property type="term" value="P:endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF117">
        <property type="entry name" value="LP05237P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS73484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="232" mass="26637" checksum="E51730D54BD615C7" modified="2019-04-10" version="1">MMYWIVFALFCTVETFSDVFLSWLPFYYELKIVFVLWMLSPMTQGSSFLFKKFVHPHLAKREKEIDEMIDQASKQGYTTLVTLGTKGLQTLMKTAIIGQSKLVDHLRRSYSTSDLSNDGHNLIQRHEALADQEEGEDELDNRLLEDNAELDRRMKSQSTKRSSSSGISLSSVKEEEGENGEHVITETYSIPQSQSTKRQFSPRETKQLNTYGTVPRLRGRTRATARKSILPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AVV0</accession>
    <name>A0A3S1AVV0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amine oxidase</fullName>
            <ecNumber evidence="7">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_023561</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="7">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="6">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6 7">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="7"/>
    <dbReference type="EMBL" id="RQTK01002116">
        <property type="protein sequence ID" value="RUS68677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AVV0"/>
    <dbReference type="STRING" id="188477.A0A3S1AVV0"/>
    <dbReference type="OrthoDB" id="6149684at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF20">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0801">TPQ</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="10">
        <location>
            <begin position="110"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="9">
        <location>
            <begin position="182"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="6">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS68677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="281" mass="31737" checksum="97B17091C0852D90" modified="2019-04-10" version="1">MTSFTNKPGRAWQVSTGILLVVCIGLLIALIVVASEDKTTTKLVTVTSDGQEVAECGESNPNGNSIDLREPSSPGPFHDLTEEEMKKLRTFLQNDPRIRANTFEEIATLNTKSSYAYMVDLWVPPKSEVLDFLDSGGPQPARQARVMMFRGDKSPPVVEEWICGPLPDVTNCDLMNFTNRRNPVEFESRTILVVGNYDYVIDFIFHQNGVIETRLMSTGYIQGNVFRAVERQYGFRLEETLTANLHHHMFHLKVDLDVSGTSNRYETLNVEPMATKICWVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AYD3</accession>
    <name>A0A3S1AYD3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_021832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001417">
        <property type="protein sequence ID" value="RUS70404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AYD3"/>
    <dbReference type="STRING" id="188477.A0A3S1AYD3"/>
    <dbReference type="OrthoDB" id="6059742at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS70404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="479" mass="54526" checksum="76584C4D6B2E9416" modified="2019-04-10" version="1">MAADTKEFNKVVDIPFPEVPPTVKSKHTVQEQIDEMRLWFKAFKEQDHSVRDYRKYFKPNLCYLEGGWTLNAKTLDEPFQSDRHQLDATSWFDLQEKIRWTSYAGSKSNLENFAFLPTMMYNITDGLPQYAQWNYRILCHPLKQDVPTSYLKVQDDLSTRMRRKYRWDKIESQRSARYKINEFGTERNTQYTFLDALMAEIPGKDNYGANISDAAFGLQTFDISKSGNVPLNAGHYHRWYKVARAGAMGLQSLGDKEQRFLCFDVNGNSSYVNYKHNLSLDPLFNLSLSLSPPLSLSPSLPPSPSTPVEFYHGDTSEHDAADTARSGASVLDAKGDLKRCAPTGFRILTPNIDGVGSVRIRYPVFPVHSEGSTVGMELEVHRSHYTCFFVAGCTSLHVVTPPRNPPGLHGHEFTITAAEHKALLNGTDLQVTTSYNLGHNHQLTIYWHQNQHVYYIRKCDDQTVACWDGHGALLTRVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AZH6</accession>
    <name>A0A3S1AZH6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_016106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000685">
        <property type="protein sequence ID" value="RUS76136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AZH6"/>
    <dbReference type="STRING" id="188477.A0A3S1AZH6"/>
    <dbReference type="OrthoDB" id="6139357at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF8">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS76136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="382" mass="44158" checksum="66108CA32B8032F7" modified="2019-04-10" version="1">MQLYFHRTEKRFRGRPTTTLPVTINKDLSQIQDNLSLKSTDDLEYLRSLAQDRNQSNQDGRGKNDFSVVSTANLSNQLHRIQRGVRQGCVMSPSLFNLYTEIIFRNINELPGMNISGQNINNIRYADDTALVAETPEQLQALLDKVNEESENCGLAMNAKKTKVMVISRKDITPKININIGNTVLEQVSTFIYLGQLISDDNRADQDIKRRIGIAKTSFNSLLNTFTSNSISMKTKLQLLKTFVWSNLLYGSETWSISKAQMNKIEAFEMYAFRKIRKISWRQKLTNYEVLQKLNIRREIGQCIRDRKLQYYGHIMRHESVIRDLYNGEVEGSRGRGRPRTKWNDNIAEWTCYSLVQCQRLAQDRCQWRAIAANLRKETAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B2W3</accession>
    <name>A0A3S1B2W3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_018517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000907">
        <property type="protein sequence ID" value="RUS73711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B2W3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS73711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="155" mass="15882" checksum="A61B94D595A3401F" modified="2019-04-10" version="1" fragment="single">AVLSDLSSSSSSARSAQRVDHSGQQVEVALELTGGRAHSQVEAAREDVQTSERTTGRALAGSVFPTTLGGAAVSTATRSSASLATNASNGVTQVAEDLRESTRLLLDGALSVADVRARGGVGGVAEEGDDGQNCEGLHRGVCWAWCELVQMSGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B5Z3</accession>
    <name>A0A3S1B5Z3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 17">Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase</fullName>
            <shortName evidence="17">GNT-I</shortName>
            <shortName evidence="17">GlcNAc-T I</shortName>
            <ecNumber evidence="14 17">2.4.1.101</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15 17">N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">EGW08_016479</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">EC2010</strain>
            <tissue evidence="18">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 17">Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + UDP-N-acetyl-alpha-D-glucosamine = N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11456"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="Rhea" id="RHEA-COMP:14368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60625"/>
            <dbReference type="EC" id="2.4.1.101"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="17">The cofactor is mostly bound to the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 17">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Golgi apparatus membrane</location>
            <topology evidence="1 17">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the glycosyltransferase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.101" evidence="14 17"/>
    <dbReference type="EMBL" id="RQTK01000714">
        <property type="protein sequence ID" value="RUS75753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B5Z3"/>
    <dbReference type="STRING" id="188477.A0A3S1B5Z3"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003827">
        <property type="term" value="F:alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000055">
        <property type="entry name" value="Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004139">
        <property type="entry name" value="Glyco_trans_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052261">
        <property type="entry name" value="Glycosyltransferase_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10468:SF0">
        <property type="entry name" value="ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 2-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10468">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE 1/ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 2-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03071">
        <property type="entry name" value="GNT-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 17" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 17" id="KW-0464">Manganese</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU368119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RUS75753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="283" mass="33158" checksum="1D13A04CC437B1FB" modified="2019-04-10" version="1" fragment="single">KLLQYRPSASKFPIIVSQDCGHAQTAGVIQKYVRSHNITHIKQPDLSNIELPANKKKWVGYYKIARHYKWALDQIFITMNYPAVIIVEDDLDVSPDFFEYFSATYPLLKQDPELWCVSAWNDNGKQGMVSSEAELLYRTDFFPGLGWMIERKLYVDELQKTWPETFWDDWMRHPDQRKGRQCIRPEICRTSTFGKKGVSKGLFYEKHLKFIKLNSDFVPFSKMDLSYLLKENYDPMFKKTVYSAPVMTAEKARSNAMPSEKVVRVEYTSKESFKRQAKLLGIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B6I8</accession>
    <name>A0A3S1B6I8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_011269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="RUS80994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B6I8"/>
    <dbReference type="STRING" id="188477.A0A3S1B6I8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="BONE MARROW PROTEOGLYCAN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CELL WALL ADHESIN EAP1"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="27"/>
            <end position="38"/>
        </location>
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            <end position="100"/>
        </location>
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            <end position="124"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="242"/>
            <end position="302"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS80994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="603" mass="66104" checksum="8047D8B5A320D18E" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B8A9</accession>
    <name>A0A3S1B8A9_ELYCH</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">EGW08_017773</name>
    </gene>
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        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
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            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000829">
        <property type="protein sequence ID" value="RUS74457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B8A9"/>
    <dbReference type="OrthoDB" id="6214951at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS74457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="639" mass="69548" checksum="558CDC926E1913FC" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B8Z0</accession>
    <name>A0A3S1B8Z0_ELYCH</name>
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        <recommendedName>
            <fullName evidence="13">E2F/DP family winged-helix DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_013436</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
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        <lineage>
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            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the E2F/DP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000489">
        <property type="protein sequence ID" value="RUS78786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B8Z0"/>
    <dbReference type="STRING" id="188477.A0A3S1B8Z0"/>
    <dbReference type="OrthoDB" id="5318at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000073">
        <property type="entry name" value="E2F transcription factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000100">
        <property type="entry name" value="E2F transcription factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015633">
        <property type="entry name" value="E2F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081">
        <property type="entry name" value="TRANSCRIPTION FACTOR E2F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR EFL-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="WHD_E2F_TDP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01372">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="13">
        <location>
            <begin position="329"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="13">
        <location>
            <begin position="474"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="160"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="267"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="631"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="873"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="193"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="631"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="880"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="910"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS78786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1033" mass="113495" checksum="5118F788228FDBB8" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BD40</accession>
    <name>A0A3S1BD40_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_011046</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000351">
        <property type="protein sequence ID" value="RUS81181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BD40"/>
    <dbReference type="STRING" id="188477.A0A3S1BD40"/>
    <dbReference type="OrthoDB" id="10031759at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038834">
        <property type="entry name" value="CCDC175"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35347">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35347:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="645"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="730"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="93"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="156"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="353"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="645"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="736"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="759"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS81181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="798" mass="92722" checksum="39949D27FC333708" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BDL6</accession>
    <name>A0A3S1BDL6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_010705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000332">
        <property type="protein sequence ID" value="RUS81535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BDL6"/>
    <dbReference type="OrthoDB" id="6161632at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS81535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="200" mass="24292" checksum="4AE3DDC810B879AF" modified="2019-04-10" version="1">MKAILKERRRIGLEYVGRKYNSEGNSYVKEVKPARKILDRCLQPLVPKQRKYRADQRTNAEKCRDYRLRLKAEDPSKFQDFKLKSNACAKKWRDNMSEEERQRQRERARQRQQQYRLRRKEMMKDLPSTPKPKPAKPAKHPKSPRLLENEADLIRERNRIRQARRRAKIKANPQQYEIEKKKEKEELLDEKVELKGCRHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BEG7</accession>
    <name>A0A3S1BEG7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_010089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000300">
        <property type="protein sequence ID" value="RUS82155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BEG7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS82155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="427" mass="48890" checksum="8B1025F5952FCE79" modified="2019-04-10" version="1" fragment="single">MSRHSSRESGRFSSSAHSSSRRSSRSLSYCQSDLDRAYQDLATYSRHEDFFRCYRELDDQDRPLTNVWEGVNGLMEHVLHKFPMPDKAPEESRLESSSKKRGRSREGNKCDPSNLEQKSTGMEEKTKNHLHNPRKSFSGLTHSHTSDIDNKKDKVGNDVCDSSQVSLEVKESSKQCEGEEESFMVLDSCGEVDVDMDDIAQVFEDDDEPIKVDDIISSEVQDEDELMLAFASDDDKEANIQDPPTNIDSTSDFPVLCAEKNSVVLADDVSPNESDFNRPSELERIIYKPHTYSVTDAETVEADIQKKFTFFDRAVKVLGTRFHTIKSGLLKKSRMKEVIEDFDLYKFSELSCLAVALFSEMEVFRLTVNPVNTENLFKIPATYNLSEKERKSFLDCYTALTQKLKQLAKQFESFLEDYPKEIFKFND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BG94</accession>
    <name>A0A3S1BG94_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_009008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000252">
        <property type="protein sequence ID" value="RUS83244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BG94"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS83244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="101" mass="10709" checksum="380323E086211C0B" modified="2019-04-10" version="1" fragment="single">MGRQRHATFVAVGARTRRTAVEVRGRRATEGTTDVDDTGGRARLTVLLLMVMMMVMVVGGVAVVPYVVVVGVRGRVYHRLVGRWRGGDGAGSSTTALVVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BGT6</accession>
    <name>A0A3S1BGT6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_008956</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000250">
        <property type="protein sequence ID" value="RUS83276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BGT6"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="AntiFam" id="ANF00095">
        <property type="entry name" value="Shadow ORF (opposite ABC transporters)"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS83276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="135" mass="14438" checksum="C78F58266E35D965" modified="2019-04-10" version="1" fragment="single">TANEVVNICLLGSLNDFGHGDLSGVVTVGDVLRDAVVKEHGLLGHDADLLAVPAQVELLQIMPFHHLSSRVNLVESLQELCRGALAAATGAHQGHRLSREDGQPQLVQDALVGPRHVMEHHVLQGEATCDVILKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BHL6</accession>
    <name>A0A3S1BHL6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_008152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000218">
        <property type="protein sequence ID" value="RUS84113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BHL6"/>
    <dbReference type="STRING" id="188477.A0A3S1BHL6"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS84113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="104" mass="10595" checksum="B08B894E85455192" modified="2019-04-10" version="1" fragment="single">IDHSDCSGSIIDHSDCSGSIIDHSGCSGSIIDHSDCSGSIIDHSDCSGSIIDHSGCSGSIIDHSDCSGSIIDHSGCSGSIIDHSDCSGSIQHTDRYSTLITVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BIE9</accession>
    <name>A0A3S1BIE9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_007849</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000207">
        <property type="protein sequence ID" value="RUS84387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BIE9"/>
    <dbReference type="STRING" id="188477.A0A3S1BIE9"/>
    <dbReference type="OrthoDB" id="6161254at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS84387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="18034" checksum="28971C4E52D07594" modified="2019-04-10" version="1">MTTFIYFVIGCAAAFACVAVHYRVSGSHRGTVISALSLVAKMASSGCWGATATWVVESYPTVTRSVGYGFVNMTARIGAILAPFALDLDYNFAVSYIVVGVLQVICLVLTLLLPETKGRSLQDNVRADAAENGASPTNGHHYGAVSEELDMRKAENGVHTNLTTEEIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BK58</accession>
    <name>A0A3S1BK58_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_023144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001836">
        <property type="protein sequence ID" value="RUS69095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BK58"/>
    <dbReference type="STRING" id="188477.A0A3S1BK58"/>
    <dbReference type="OrthoDB" id="550577at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018765298" evidence="1">
        <location>
            <begin position="19"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS69095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="213" mass="23781" checksum="54AAE5B843BD5771" modified="2019-04-10" version="1">MVPLGLIVALSLIAVAAPHSVAKREVQPEGYQETIIFLKKQTDFGQSVFIRGGVGNGTNCAPNESPKDDPCAIPITHIELDISAETTIRDEWAESDLYLTWGESRDEQDSVMDGTPAQWTSWDESNNDYFHPLNTYGDDYWIVHFEMNCSMLENGFFDFKGFLDGQWETDISQSDCAGNGAETPSYTSINHIARCGYINVFEWGNPDCTINAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BLC5</accession>
    <name>A0A3S1BLC5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">IST1 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Charged multivesicular body protein 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">EGW08_005880</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">EC2010</strain>
            <tissue evidence="18">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">ESCRT-III-like protein involved in cytokinesis, nuclear envelope reassembly and endosomal tubulation. Is required for efficient abscission during cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing. Recruited to the reforming nuclear envelope (NE) during anaphase by LEMD2. Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with CHMP1A, CHMP1B, VPS4A and VTA1. Interacts with SPAST, STAMBP, and USP8. May interact with VPS37B. May associate with the ESCRT-I complex. Interacts with MITD1, in competition with VSP4. Interacts with SPART (via MIT domain); leading to the recruitment of SPART to midbodies. Interacts with SPAST.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Microtubule organizing center</location>
            <location evidence="3">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Midbody</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IST1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000141">
        <property type="protein sequence ID" value="RUS86362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BLC5"/>
    <dbReference type="STRING" id="188477.A0A3S1BLC5"/>
    <dbReference type="OrthoDB" id="29853at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.60:FF:000001">
        <property type="entry name" value="IST1 homolog isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.60">
        <property type="entry name" value="Vacuolar protein sorting-associated protein Ist1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005061">
        <property type="entry name" value="Ist1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042277">
        <property type="entry name" value="IST1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161">
        <property type="entry name" value="IST1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161:SF5">
        <property type="entry name" value="IST1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03398">
        <property type="entry name" value="Ist1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="214"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="221"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="238"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RUS86362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="342" mass="37500" checksum="943F32607F55DBB3" modified="2019-04-10" version="1">MNQTLSDTNSMSGPNYTKLKTNLRLIINRLKLLEKKKTEMALKSRKEIADYISAGKEDRARIRVEHIIREDYLVEAMELLEMYSDLLLARFGLIQTQKELDPGLEEAIASIIWATPRLQADVQELKAVTDEFAHKYGKEFAQACRGNQLSNVNEKVMHKLSVQAPPKALVERYMVEISKSYNVPFEPDPSVMQQDEILLAENLLIDLGMEDKKNMEFGAGGPPPHQGFGPGGPPNPGFGPGGPSHPGFGQGGQGPPPLPNQPPHGGVSPYPPPAYNSGASTGPPNFDQLYDNNSDDIFPELPTVPSNTLPDPGNSIGGGSVGGEDVDFDDLTRRFEQLKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BMB4</accession>
    <name>A0A3S1BMB4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_005279</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000123">
        <property type="protein sequence ID" value="RUS86954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BMB4"/>
    <dbReference type="STRING" id="188477.A0A3S1BMB4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS86954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="229" mass="25004" checksum="57E3932B6AA767A7" modified="2019-04-10" version="1">MGFLCFSKLAELKWLNITKILFSSILYAMAQALESMIQPLACGAYLLTTVKEKSSLLTTVKEKSSLQAYLLTTVKEKSSLQTYLLTTVKEKSSLQAYLLTTVKEKSSLQAYLLTTVKEKSSLQAYLLTTVKEKSSLQRLPVDHCEGEVQPTGLPVDHCEGEVQPTGLPVDHCEGEVQPTGLPVDHCEGEVQPTGLPVDHCEGEVQPTDLPVDHCEGEVQPTAQALGRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BP99</accession>
    <name>A0A3S1BP99_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_004010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000089">
        <property type="protein sequence ID" value="RUS88244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BP99"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS88244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="270" mass="30121" checksum="D8C4147189D3667E" modified="2019-04-10" version="1">MLRVGFTSWGRPDHFAFAQHRGSDVLHTGSALVCDIVERSGACCCSDCARCPTQARHQAWFEIHLETALHVIYDTEEARATRVDFFYDDDQAIAAGRRKTVWASEVKHIHSEADFCSFVCATHDTSLVRQLQQHLAQSTKTKFYGLSGCWMSAGWDHVCVIASHPHGQPKKITVGRLTNERELSPLHRYFIYSVDTCPGSSGARGAVIELSKGKRSSRFSMRLLPPHSSRLGSREINVSSASVAGYAQPEIAGLLENIRFNPMWLNSAIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BPL0</accession>
    <name>A0A3S1BPL0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_006531</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000161">
        <property type="protein sequence ID" value="RUS85737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BPL0"/>
    <dbReference type="STRING" id="188477.A0A3S1BPL0"/>
    <dbReference type="OrthoDB" id="6144264at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Peptidase A2" evidence="8">
        <location>
            <begin position="112"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="9">
        <location>
            <begin position="359"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="701"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS85737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="790" mass="88069" checksum="25ACB0D8C3547D69" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BSJ5</accession>
    <name>A0A3S1BSJ5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_001761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000031">
        <property type="protein sequence ID" value="RUS90493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BSJ5"/>
    <dbReference type="STRING" id="188477.A0A3S1BSJ5"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS90493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="331" mass="37711" checksum="C3D1F06E1DFBC630" modified="2019-04-10" version="1">MRETTSILSNPEWSRKDAVHRSSPSDLVLVRPRAIIQAARGEFSCRENAGDNADDDDDDDDDDDDDDDDDDDDDDDDDDDDNDDDDDDDVNDDKYDDDDDYDDNGANDNIIPIAQRDMQRGYNYKRTDTHKQTFKQTNKTQLQTALAGRAARETGRETLPEMLASRFPSPPVTLSSPVNNVRVIRIGASTFSARLPGRLWTDCWVSGWPRDGMERGPHPLAKHKARSSRPRYTTSKIMMLMRIVLVKCDDNCGDGCVGYDDYYVYDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDRDDDYDSDNDNEILDFDGSRDNDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BSM4</accession>
    <name>A0A3S1BSM4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein 185B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_018287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000882">
        <property type="protein sequence ID" value="RUS73949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BSM4"/>
    <dbReference type="STRING" id="188477.A0A3S1BSM4"/>
    <dbReference type="OrthoDB" id="72976at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019396">
        <property type="entry name" value="TM_Fragile-X-F-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13568">
        <property type="entry name" value="FAM11A, B PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13568:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 185A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10269">
        <property type="entry name" value="Tmemb_185A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS73949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="41173" checksum="400EA74EEA3165A2" modified="2019-04-10" version="1">MNLKNFFQDFNPSKFVVFSSLLVFCLLFSLRLDGTVDWSYWFVFLPIWLWKLLVFAGALIGAAVWLRNPQYRTEADSAGQFTAMILTWGEHMVLLTFEVLAVFNLQSGTSKWLVAFVPLFVLSVFSIGACIWSVKHRRSCELELFCAANVLQFIFLALKLDDVIEWRWVIVFIPVWIVMCIALIGVLYAVVLAIILVRSPDVLSEHRRGNMSVAVGYMFFVVPLLVFEILLANRLDHVNDFNFAFVVIPLLMSLASLMCLSFGAKGGNFWWFGIRKDFCQFVLGACPCLQEYGNISYSIQRDDQDSVVESPPPSHAPGLGMPPSDLSPYISSSDLPDVQCGKPGGAGRGQLEMPRVVVPVLAIDMPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BT27</accession>
    <name>A0A3S1BT27_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_017986</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000851">
        <property type="protein sequence ID" value="RUS74248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BT27"/>
    <dbReference type="STRING" id="188477.A0A3S1BT27"/>
    <dbReference type="OrthoDB" id="277832at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22419">
        <property type="entry name" value="KH-I_ASCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019510">
        <property type="entry name" value="AKAP7-like_phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009210">
        <property type="entry name" value="ASCC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047538">
        <property type="entry name" value="KH-I_ASCC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360:SF1">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10469">
        <property type="entry name" value="AKAP7_NLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027019">
        <property type="entry name" value="Euk_LigT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="2">
        <location>
            <begin position="66"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS74248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="367" mass="41019" checksum="AA786DCEB05039D6" modified="2019-04-10" version="1" fragment="single">SETTKLLKRSYELVWIGKRCYRKNALKDNPNFNPEDEEFYDADQRSDMTYCDESCDQDLDIEVTNRGFCLRVPVASAYNKYIIGKKGETKRRLEAETKTQIAVPKPGDKEEVIVISGQDKKGIVSAKTRIDVLVDSARQRQPFTHFLSIPVTSDDIITGFENFKDDVLRLCDGDEGVDESIFQNPSKLHLTLGTLALLSRAEVDKASELLASCRDELISPTLRGEPLTVHITGLEYMNDDPGAVDVLYAKVKDGPAATRLQTLADGLVDRFSRAGLLQQSDFARVKLHVTVMNTLFRRDPSPDAGSPQAGVGHRRAREAFDARPVLKNFKAYEFGSLTIRSIHLSQRYSTGPDQYYQCVTSADLPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BT67</accession>
    <name>A0A3S1BT67_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WWE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_001521</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000026">
        <property type="protein sequence ID" value="RUS90717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BT67"/>
    <dbReference type="STRING" id="188477.A0A3S1BT67"/>
    <dbReference type="OrthoDB" id="69269at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058055">
        <property type="entry name" value="PA-PLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004170">
        <property type="entry name" value="WWE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037197">
        <property type="entry name" value="WWE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057825">
        <property type="entry name" value="WWE_SEC23-DDH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509:SF10">
        <property type="entry name" value="LD21067P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509">
        <property type="entry name" value="PA-PL1 PHOSPHOLIPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02825">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23464">
        <property type="entry name" value="WWE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117839">
        <property type="entry name" value="WWE domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50918">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="625"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="WWE" evidence="4">
        <location>
            <begin position="224"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="570"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS90717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="668" mass="74080" checksum="016DC099A4E8C1A5" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BXH1</accession>
    <name>A0A3S1BXH1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_014808</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000581">
        <property type="protein sequence ID" value="RUS77430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BXH1"/>
    <dbReference type="OrthoDB" id="10042433at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS77430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="122" mass="13726" checksum="6F3ED46666C6A522" modified="2019-04-10" version="1" fragment="single">TLLYTSAHCCTLLYTAAHCCTLLYTAVHCCTLLYTAPNCFTLLYTAVHCCTLLHTAVKLLYTAVHCYTLLHTTTHCCTLLHTAAHCCRLLYTAIHCRTLLRTAPNCFTLLYICTFLYTTAYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1CG06</accession>
    <name>A0A3S1CG06_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_000639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000008">
        <property type="protein sequence ID" value="RUS91666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1CG06"/>
    <dbReference type="OrthoDB" id="10646401at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS91666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="215" mass="22943" checksum="2A1F776F7BA0DFE5" modified="2019-04-10" version="1">MHPTLQLESELVTWSPTPSLRRATPTGGAQTQDGRRGCVSFLRGAGLATFTFAVPSVRRAAARVLDSLALAPHLHPLTYLYGGLGGLGGLGGLQAALTAEHIKSCQSSLGSMLAPVGVATSVSGGSAFSIDSILSRPGPMSSFPSPPSHLQQQLQQHHHHQQQQQLQHVHQQQSQHRPAPYFPCCVICKEIGCLSYVLGAPNVTKCWSISFFFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H3P8</accession>
    <name>A0A3S1H3P8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_020646</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001191">
        <property type="protein sequence ID" value="RUS71585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H3P8"/>
    <dbReference type="OrthoDB" id="413313at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16021">
        <property type="entry name" value="ALP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF1">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="787"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="919"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="479"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="531"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="804"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="949"/>
            <end position="965"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS71585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="986" mass="110578" checksum="9DD8114A96519FA5" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HF70</accession>
    <name>A0A3S1HF70_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine/threonine protein phosphatase 2A regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_014109</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphatase 2A regulatory subunit B56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000531">
        <property type="protein sequence ID" value="RUS78136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HF70"/>
    <dbReference type="STRING" id="188477.A0A3S1HF70"/>
    <dbReference type="OrthoDB" id="10264446at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000010">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF5">
        <property type="entry name" value="WIDERBORST, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028043">
        <property type="entry name" value="PP2A_B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR028043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS78136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="459" mass="54035" checksum="FA0811125745F408" modified="2019-04-10" version="1">MTTKMAERIDPFTAKASVKSKKPKRSQGSSHYRANSAPELQALPHLKDTPQNEQQELFIRKLQQCCVVFDFMDPVTDLKSKEIKRACLNEIVDYITATRNVLTEPVYPETVRMVACNIFRTLPPNDNPDFDPEEDDPTLEASWPHLQLVYEFFLRFLESPDFQPSLAKKYIDQRFVLQLLELFDSEDPRERDFQKTVLHRIYGKFLGLRAFIRKQINNIFLRFIYETEHFNGVGELLEILGSIINGFALPLKAEHRQFLMKVLIPLHKSRSLSLYHAQLAYCVVQFLEKDASLTEDVIKGLLKFWPKTCSQKEVMFLGEIEEILDVIEPTQFQRIQEDLFKQIAKCVSSPHFQVAERALYFWNNEYIMNLIEENSNVVLPIMFPALYRISKEHWNQTIVALVYNVLKTFMEMNSKLFDELTANYKSERQKEKKKEKDREELWKRLDRLELNSKKSNKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HLX8</accession>
    <name>A0A3S1HLX8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_010146</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000303">
        <property type="protein sequence ID" value="RUS82101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HLX8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS82101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="307" mass="34300" checksum="05A1D2A3EFCE7CF4" modified="2019-04-10" version="1">MECLCSNEYSSCIFKYEEKRSGKSIVTDVREIRERSEHSTFICKMPAGNVGEATCRREAAESNSCHSNNVCTFSRLNTWKLSDCPVSCVTLGWYLYQVNYTYLQGSEKIGQAICESARTTETILTSTTPINDRKDPTVTIAVVFACIILVLIICVFLGRVIYKKKRRESKTKAHQHAAVDSYAISKGGKNAINLDNEECDIPVDPDVQKSDVYYATVGHTYSTIPDNAPKSSEIKPGGNEGSHEPSTPGASCLPDYDSKPIFNQSNDARNIYSHLENSRENAREEISRSILRTYDLQNFLDDSQPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SIX6</accession>
    <name>A0A433SIX6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_023473</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01002029">
        <property type="protein sequence ID" value="RUS68765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SIX6"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS68765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="169" mass="19512" checksum="3332552B416072F2" modified="2019-05-08" version="1">MDQTNISSSMLSSLLHYNFSFISYISPERFCSSLIKQLQNNLDCHSVPTKKDDLNLIAFSALIELLELSKREFSSHFAGPEDNYNFCSSDIKSDRNIDTVKKVPEKEREIVHKWFSETLKIMQASKKCIAYIMVKTSQEKKCKFAKFLSRQFFLIGLKTGFFEVSGFMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SMZ6</accession>
    <name>A0A433SMZ6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenine phosphoribosyltransferase</fullName>
            <ecNumber evidence="6">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_021642</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="6"/>
    <dbReference type="EMBL" id="RQTK01001373">
        <property type="protein sequence ID" value="RUS70596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SMZ6"/>
    <dbReference type="STRING" id="188477.A0A433SMZ6"/>
    <dbReference type="OrthoDB" id="363185at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002055">
        <property type="term" value="F:adenine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000021">
        <property type="entry name" value="Adenine phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002636">
        <property type="entry name" value="PRK02304.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF3">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="12">
        <location>
            <begin position="7"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
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    <evidence type="ECO:0000259" key="12">
        <source>
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    <evidence type="ECO:0000313" key="13">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="152" mass="16793" checksum="7C7FC4423D86B10E" modified="2019-05-08" version="1">MWDILPVLRNPEVFSDLNDILYETSKSVPQVDCVVGLEARGFLFGTILAQKLQVPFVPIRKKGKLPGEIVSQTYELEYGTDCFEIQKGSIAKGQKVLIIDDLLATGGTMKAACQLVTKVEADVVLCLCIIELQGLKGVEKLDKQFKSLITFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SNZ3</accession>
    <name>A0A433SNZ3_ELYCH</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_021267</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="RUS70973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="210" mass="22637" checksum="AEED0A68F80699A0" modified="2019-05-08" version="1">MKKIVTKKHHPVSPETNVGVGLAAGESALQAGVALELWQEKPKLLGTSRPPNGLGPADLRIRQRLVSCPPYSATLISSINISLPRAQFSQESRQRSRGLLLMNCGGRRGLGDEFTDRGSDPALWVPPPQAANQLLSGLHCVKSGDHRPAAMGYRFQPREPPESSARACPSQPVSAAVRVGDSWNGFRFELAAVTPVFYPARGQYPVPSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SP37</accession>
    <name>A0A433SP37_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_021270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
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            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
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                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001294">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <sequence length="2807" mass="305287" checksum="BF9EC9ECED26BA9E" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SQJ7</accession>
    <name>A0A433SQJ7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_020749</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001204">
        <property type="protein sequence ID" value="RUS71498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SQJ7"/>
    <dbReference type="OrthoDB" id="10666562at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS71498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="479" mass="53998" checksum="A488387DE5326702" modified="2019-05-08" version="1">MGDELELDYSDWLRRETLCMLIRKAFNGEINIDTNFEGVPVTAQNLSFDEQNHITAVQADLTLCVIRDETANFYNDSTVANDVKKILYVVDANNKFGTVNSVPGGITNMRYYTNENFEADRNVRLTAARNEKQKLAYVGDGNGDDDDSNGMVNVSAPKQESAVWIKGVRLLCNIKIVAQGETFKPSENSMDLVLRLPKDNIPHQVCCFNSDAKMIFIEARLYRPKSSDVNILWISNGVATALSFGAAKYIYVLNENNGIVLHVNLYNAIQTCCNKIEFKGNTLFTSLDVLPYIQDFRATSYANGECLYTFVKPRMEMIECTTNLSDATDYLYEHIMENVVWSGPVMTLMRPSSLYEICIGCAMLFEKQTNECIIKTIVEKFATFLVAANLYNQSIFDNYGFEDGRSVAQNRTMERLYVLFSVANDINIKLSSENGNVQNFDMSCIYPSLSNNNVTVTVVDWVEIESGVTFPTPPYIVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SQZ7</accession>
    <name>A0A433SQZ7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenosine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_020664</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>adenosine + H2O + H(+) = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="4"/>
    <dbReference type="EMBL" id="RQTK01001193">
        <property type="protein sequence ID" value="RUS71571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SQZ7"/>
    <dbReference type="STRING" id="188477.A0A433SQZ7"/>
    <dbReference type="OrthoDB" id="7202371at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000017">
        <property type="entry name" value="Adenosine deaminase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013659">
        <property type="entry name" value="A_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006331">
        <property type="entry name" value="ADGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01431">
        <property type="entry name" value="adm_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF39">
        <property type="entry name" value="ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08451">
        <property type="entry name" value="A_deaminase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Adenosine/AMP deaminase N-terminal" evidence="12">
        <location>
            <begin position="47"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Adenosine deaminase" evidence="11">
        <location>
            <begin position="229"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS71571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="544" mass="62599" checksum="47C722F343EACF22" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SU65</accession>
    <name>A0A433SU65_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ankyrin repeat domain-containing protein 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_019408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001012">
        <property type="protein sequence ID" value="RUS72829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SU65"/>
    <dbReference type="STRING" id="188477.A0A433SU65"/>
    <dbReference type="OrthoDB" id="5806726at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053210">
        <property type="entry name" value="ANKRD12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24149:SF14">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24149">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS72829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="31518" checksum="1340AC2271E0F301" modified="2019-05-08" version="1">MADDSNVPHRKRKLRTKTEMQTIQTAAAAANTKLNQILEKPPNPYETYLNLRRQIASRHRTLSNVAPKAPTGFKDFLMVTCTYVLQGNATSTLSVPMLPPPSFVPAPMKEFFNQQEKDRYRLRLQHTIEREKLMLSIEQEILREHGRAARAMANQRLPFSVCTILREEEIYNLQELEQVEDREKNVRSRYNGRQFISWLQAVDDKYEKIKHVLLMRHHHEAESLFAVQKLDWEWKLKECGLCDHKITPTIDDLHVPMVSVSNEFELPPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SXR7</accession>
    <name>A0A433SXR7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">PLAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_018159</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000868">
        <property type="protein sequence ID" value="RUS74081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SXR7"/>
    <dbReference type="STRING" id="188477.A0A433SXR7"/>
    <dbReference type="OrthoDB" id="5781878at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013273">
        <property type="entry name" value="ADAMTS/ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045371">
        <property type="entry name" value="ADAMTS_CR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010909">
        <property type="entry name" value="PLAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF313">
        <property type="entry name" value="PEPTIDASE M12B DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19236">
        <property type="entry name" value="ADAMTS_CR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08686">
        <property type="entry name" value="PLAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01857">
        <property type="entry name" value="ADAMTSFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50900">
        <property type="entry name" value="PLAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019123769" description="PLAC domain-containing protein" evidence="7">
        <location>
            <begin position="25"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="654"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="PLAC" evidence="9">
        <location>
            <begin position="990"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="36"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="40"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS74081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1032" mass="116633" checksum="A49D46F44262ED7A" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T0U9</accession>
    <name>A0A433T0U9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_017063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000765">
        <property type="protein sequence ID" value="RUS75182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T0U9"/>
    <dbReference type="OrthoDB" id="6060392at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="657"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="787"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="425"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS75182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="819" mass="89576" checksum="2BF070B6B9601DE4" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T1C3</accession>
    <name>A0A433T1C3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Iduronate 2-sulfatase</fullName>
            <ecNumber evidence="15">3.1.6.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Alpha-L-iduronate sulfate sulfatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">EGW08_016903</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">EC2010</strain>
            <tissue evidence="20">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Lysosomal enzyme involved in the degradation pathway of dermatan sulfate and heparan sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin.</text>
            <dbReference type="EC" id="3.1.6.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Monomer. The 58-kDa mature form is composed of two chains resulting from proteolitic processing, the 42-kDa chain and the 14-kDa chain that remain stably associated and form the 58-kDa intermediate form which is enzymatically active.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.13" evidence="15"/>
    <dbReference type="EMBL" id="RQTK01000751">
        <property type="protein sequence ID" value="RUS75336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T1C3"/>
    <dbReference type="STRING" id="188477.A0A433T1C3"/>
    <dbReference type="OrthoDB" id="96314at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043202">
        <property type="term" value="C:lysosomal lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004423">
        <property type="term" value="F:iduronate-2-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901136">
        <property type="term" value="P:carbohydrate derivative catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16030">
        <property type="entry name" value="iduronate-2-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000027">
        <property type="entry name" value="iduronate 2-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035874">
        <property type="entry name" value="IDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45953">
        <property type="entry name" value="IDURONATE 2-SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45953:SF1">
        <property type="entry name" value="IDURONATE 2-SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0458">Lysosome</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 18" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019307327" description="Iduronate 2-sulfatase" evidence="18">
        <location>
            <begin position="32"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="19">
        <location>
            <begin position="34"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00062513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00081076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RUS75336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="724" mass="82873" checksum="4CF81DB5C482AF55" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T222</accession>
    <name>A0A433T222_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_016651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000727">
        <property type="protein sequence ID" value="RUS75587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T222"/>
    <dbReference type="OrthoDB" id="6038787at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS75587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="185" mass="22483" checksum="A6F7ECF8A5F07DCD" modified="2019-05-08" version="1">MADTLFFKRSQTMYPYNVNMPPTVPRYPASQDMFRREEPEKYTQRKGRAGYQNWTDKWYDWEHPVRRQEELPQIADRQEPLSRPWEYGVHMGVVGQPKWTREGKDWPINNKKYLRSGIPNTENHRARAIREMSFRDDKLYPFSNYMTSTYRRPVYSVFGPMQKDPVFGLTRQRSRHGHMPFEDYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T4G2</accession>
    <name>A0A433T4G2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3456 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_015826</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000664">
        <property type="protein sequence ID" value="RUS76416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T4G2"/>
    <dbReference type="OrthoDB" id="448621at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034663">
        <property type="term" value="C:endoplasmic reticulum chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021852">
        <property type="entry name" value="DUF3456"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052682">
        <property type="entry name" value="MZB1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15881">
        <property type="entry name" value="MARGINAL ZONE B- AND B1-CELL-SPECIFIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15881:SF2">
        <property type="entry name" value="MARGINAL ZONE B- AND B1-CELL-SPECIFIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11938">
        <property type="entry name" value="DUF3456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019149362" description="DUF3456 domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3456" evidence="3">
        <location>
            <begin position="90"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS76416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="213" mass="24015" checksum="995C4D0B9972AF64" modified="2019-05-08" version="1">MYCMNASSTAFFLGFLLLGVFVCQSEVAKNDDPKSRKFSEDDRQYLKDSGLDPDSLSPDTVIIKPPSYTDEEETSIGMPAAYRCDGCRVISYQLQESFSKEEKKRGGSKALSESDLIDAVERVCKDEFESYGLMSTPTGEKFLKGPGLGRTQTSGSVDKGPMWPKRLRHMCLEILDVYDEDELYEMYRESGSSLVETELCDRYCSKGKRKTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T5Y7</accession>
    <name>A0A433T5Y7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_015235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000618">
        <property type="protein sequence ID" value="RUS77010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T5Y7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS77010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="91" mass="10294" checksum="5BBCC83CBDA94BCB" modified="2019-05-08" version="1" fragment="single">YLHALLPRYPEVTPGEEASYSMSGQVVNPTFPPQLHHNCINPWEALIMTYLCPFGQCLWVVLPRNLHTDGVSNHTIEVWVIGSHCIKKLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T6G6</accession>
    <name>A0A433T6G6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_015199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000615">
        <property type="protein sequence ID" value="RUS77042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T6G6"/>
    <dbReference type="OrthoDB" id="6071741at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS77042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="23105" checksum="DE5BB65BB7AF0067" modified="2019-05-08" version="1">MYNISGWNETAWKASNNRYSIWPGVEILTVERYLVPCIVCLGMLTSTLSCAVLLRTHLRKKFYSHFLVGESVSCLGFLATVLVNWMHDQGLAVFRVPGLCQVNVFCSHFFLCLVIWLTMTSALLILFDLTRSSPVRWMNSPSVSKVWVLGQYTAQNLGVSHFFLCLVIWLTMTSALLILFDLTRSSPVRWMNSPSVSKVWVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T8R0</accession>
    <name>A0A433T8R0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Ribonuclease P/MRP protein subunit POP5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_014339</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic/archaeal RNase P protein component 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000544">
        <property type="protein sequence ID" value="RUS77908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T8R0"/>
    <dbReference type="STRING" id="188477.A0A433T8R0"/>
    <dbReference type="OrthoDB" id="24745at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3250">
        <property type="entry name" value="Ribonuclease P, Pop5 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002759">
        <property type="entry name" value="Pop5/Rpp14/Rnp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016819">
        <property type="entry name" value="RNase_P/MRP_POP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038085">
        <property type="entry name" value="Rnp2-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48414">
        <property type="entry name" value="POP5 HOMOLOG, RIBONUCLEASE P_MRP SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48414:SF1">
        <property type="entry name" value="POP5 HOMOLOG, RIBONUCLEASE P_MRP SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01900">
        <property type="entry name" value="RNase_P_Rpp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023803">
        <property type="entry name" value="Ribonuclease_P_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160350">
        <property type="entry name" value="Rnp2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR023803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS77908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="179" mass="20012" checksum="2E7B8536A1A30ED8" modified="2019-05-08" version="1">MVRFKNRYAICELVFPQTAESGPQMETYQVYQAVKQSLLESHGDYGLAALQSSLSVKYLNIKTNIAIIRGERRHFDMVTSSLIFITEVGGLDVAFRTLHVGGSIRSCQKFLIDYHRKNLAKLFPECETLEGKSEVMKSIMAACDSLVQAHKQQARQAGGIAPYSALSMLQQGEEEMDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T959</accession>
    <name>A0A433T959_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_014156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000534">
        <property type="protein sequence ID" value="RUS78076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T959"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS78076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="132" mass="14620" checksum="964D9CAC9752DE46" modified="2019-05-08" version="1">MSRGLRARAIYSPAQDHDPEAKLFSSGEEDGEDETLFQMDPSQRSGSSDVHSRSREMGRGDGDQAQRDMVDLSKETKPETYTLEEAVEAIGMGWFQIKMYLICGVVGVSCARFSVLMSCDDLISIPKAKFAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T9Y6</accession>
    <name>A0A433T9Y6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_013843</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000512">
        <property type="protein sequence ID" value="RUS78395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T9Y6"/>
    <dbReference type="STRING" id="188477.A0A433T9Y6"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01865">
        <property type="entry name" value="Rab3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000206">
        <property type="entry name" value="Ras-related protein Rab-3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037872">
        <property type="entry name" value="Rab3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS78395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="262" mass="29802" checksum="E78F520036714EF4" modified="2019-05-08" version="1" fragment="single">EFRVNTFHVCRLSVCSLKYIECTTSNIASIKKIPVMRSDGVTQMASANDSKWQKDAADQNFDYMFKLLIIGNSSVGKTSFLFRYADDSFTSAFVSTVGIDFKVKTVFRQDKRVKLQIWDTAGQERYRTITTAYYRGAMGFLLMYDITNEESFQAVQDWCTQIKTYSWDNAQVVLVGNKCDLEDERVVSTDRGKQLADQLCLEFFETSAKENINVKAVFERLVDIICDKMSESLDADPTLVNNQSKSTRLSENQMANNSSCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TA82</accession>
    <name>A0A433TA82_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_013804</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000510">
        <property type="protein sequence ID" value="RUS78430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TA82"/>
    <dbReference type="OrthoDB" id="6286464at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF306">
        <property type="entry name" value="RE01051P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="510"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS78430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="578" mass="62365" checksum="057CF8D880AFE6AE" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TC36</accession>
    <name>A0A433TC36_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Trichoplein keratin filament-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_013094</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TCHP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000468">
        <property type="protein sequence ID" value="RUS79147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TC36"/>
    <dbReference type="STRING" id="188477.A0A433TC36"/>
    <dbReference type="OrthoDB" id="6431598at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045095">
        <property type="term" value="C:keratin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043596">
        <property type="entry name" value="CFAP53/TCHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043597">
        <property type="entry name" value="TPH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31183:SF2">
        <property type="entry name" value="TRICHOPLEIN KERATIN FILAMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31183">
        <property type="entry name" value="TRICHOPLEIN KERATIN FILAMENT-BINDING PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13868">
        <property type="entry name" value="TPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trichohyalin-plectin-homology" evidence="9">
        <location>
            <begin position="145"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="419"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="179"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="428"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS79147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="499" mass="60879" checksum="68025282F526D6C6" modified="2019-05-08" version="1">MALPTMTGYWSSRKNIYEQAIVSQRNREDDFRNKWSDTANYFKKSDVRAAKQNAWSSTQAFQDRCMSAYEESVDRDVKSSNLKRRRDKLGRLLAEENQAFQDELKGLSRPSTARLEDMKARADGLKSAREEKRQKLAEEKLYQHWRENNPELRKAESEMLNEHVVGEWGDQMCEKEERLESARQENEVFARQMEEERLAALELERQREEARLTEQKSLKEVLREQMLEFKTREAEAKQWRLHQEELMRQKWELEQIEEQQRQREEERRKKDLGRALLRQHKAQMMRKSRVIQEELEQDRQLLESLIEKETENATLQTARREQSRADAQWMKQVIEDQLKLEKAREAELDMLYQEEAARMWQKRESEWEKERQARQRLMAEVLEERQAQISDQLHELQQQQEESLVRREELVREMELAQREARQEEEDRERGKLTTRVDLEEQMHNRQRQEAEARERERFELRHERKEEEDYEDLLRQETQRMRLQGFTPRDHSRKQAWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TC93</accession>
    <name>A0A433TC93_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_013191</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000475">
        <property type="protein sequence ID" value="RUS79034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TC93"/>
    <dbReference type="STRING" id="188477.A0A433TC93"/>
    <dbReference type="OrthoDB" id="199913at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Lipase" evidence="5">
        <location>
            <begin position="95"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS79034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="383" mass="42479" checksum="9D6BEE26EB63B8C8" modified="2019-05-08" version="1" fragment="single">RNVNLKRLLFCRIRKIAFVVRSVVTAVFSWRFIMGLQAVLFTLCVTVVACASDINFLDCKVKENSWSYWRNCCKSAKLPNGCECYDIWSSDFTNSFYNLPLCPKNLKVSFLFFDRDHRENATVLQSKTELSDLPFSGTKRSVFVTHGFNDRGGGNWTLTIKDALLETEDLNVVLVDWGYAANSVNYLKPVANTRSVGAMVAKLILDLNQHTGAPFTNFHLVGHSLGAHVCGIAGEEIKRLTGQKLGRITGLDPAGPSFESYSTKVRLDSSDAEFVEAIHTDSEPLYSSGFGIRISCGHVDFWPNGGEHQPGCPEETWGILGMLNFEADFSSGACSHSRAISLFTDSITLCRYDPQGPCTMGYHTAETCRGNYYPDTLSAEPFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TDL2</accession>
    <name>A0A433TDL2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_012605</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000438">
        <property type="protein sequence ID" value="RUS79636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TDL2"/>
    <dbReference type="STRING" id="188477.A0A433TDL2"/>
    <dbReference type="OrthoDB" id="6152035at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019145337" description="Chitin-binding type-2 domain-containing protein" evidence="6">
        <location>
            <begin position="26"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="32"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="104"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="171"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="235"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="311"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="384"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS79636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="461" mass="50399" checksum="04BEFC290C281F44" modified="2019-05-08" version="1">MMAFGHGNLPAIGTLVLLCAASVLTQLITNPYITCHGQYNRLFQDASDCSSYIVCNNDRLTRASCPVGQVFSPVHNSCGNYQTPSGCQNFGLFQTQGDAHPTPTYKCPDSHGKFQDTNDCSGYYVCTNYQSHWYQCPNGQMFDPNNEVCSNIHNPVGCHAPGAGAVTSRGTGSCNQNNAISQDVNDCSKYFVCTNYILQSRTCPSGQLFDPSRSSCGYTQNPAGCTMPVYQRQGTFRCNQANGQVQDTADCSRYYLCTNWDAQSLACPIGQLFDPNMGMCGSIVNPGHCNMPENWLPVVGGTTWGSQTLTSFQCRQSSGQFQDTADCSRYYMCTNWTPQRLMCPSGQLFNPTTGVCGSITNPGHCQMPVTWTGGSTWSGQSSNSYNCPEGNGEFPYAPDCSKFLRCDNYRGTLMSCPGSLLFNPNRGYCDWSEQYSTHNSCTLPARMTGGNQILNAVGYYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TE76</accession>
    <name>A0A433TE76_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_012392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000424">
        <property type="protein sequence ID" value="RUS79866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TE76"/>
    <dbReference type="STRING" id="188477.A0A433TE76"/>
    <dbReference type="OrthoDB" id="6151888at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS79866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="253" mass="28858" checksum="44648A8589827D0D" modified="2019-05-08" version="1">MTRGKWVPRSYTKKEMDTLSEFVRMSREQHFLPPSLERPDGLCGNVTFSHLAGKMHNLLWFRALCDPQGSNPCCFNNKCTGGLSVQECQCPHCYDMRQPIHAEFATWVPSDPVCKIKQFHNKTDTCQMLGNSTVLMIGDSFMRHVYIALLSLLRSDLPHGPKVAKATSVQRFMCRGDYIYQQRCHALLDRDTNHCKNTTKLKFYEYISSKEGPVILNTITKLRDIPNSYVFLGIGIHDDFHFNIIAATSFGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TIA7</accession>
    <name>A0A433TIA7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_010946</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000345">
        <property type="protein sequence ID" value="RUS81304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TIA7"/>
    <dbReference type="STRING" id="188477.A0A433TIA7"/>
    <dbReference type="OrthoDB" id="10651781at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS81304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="274" mass="31508" checksum="E0E27E2E9333941B" modified="2019-05-08" version="1" fragment="single">VIELRYTMTLLRHVIVPRCMLGIRQVSHRAKVYYDSIETGHRAKVYTIRQVSLKAKVYYDTIETGHRAKVYTMRQVSHRAKVYYDSIETGHRAKVYTIRQVSHGAEVYTIRQVSHRAAVYTIRQVSHGTEVYTIRQVSHRAAVYTIRQVSHRAAVYTIRQVSHGTEVYTIRQVSHGAEVYTIRQVSHGAEVYTIRQVSRGAEVYTIRQVSHGAEVYTIRQVSHGAEVYTIRQVSHGAEVYTIRQVSHRAAVYTIRQVSHGTEVYTIRQVSHGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TIB3</accession>
    <name>A0A433TIB3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_010963</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000346">
        <property type="protein sequence ID" value="RUS81289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TIB3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS81289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="200" mass="22244" checksum="9ECEF5BA3A43E330" modified="2019-05-08" version="1">MLAFHAILSQVKKDNACILLVLEKTLPNSLDWTSTDNRSHLGDETPNLFKKNPPYAATLTTHLDKVLSVHATTTRHKATGLNNKWTEILDKTLTIAQPHRFLHPRRFRPPPSQSIYCPTFFYPSTLQTSSISVTVSRCNKLPGRVSANRNCSSPGANPAIASDARTTQIRPLLQQWVCAKSPSRQVGKCPLILSIVQRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TIC5</accession>
    <name>A0A433TIC5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_010905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000343">
        <property type="protein sequence ID" value="RUS81338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TIC5"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS81338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="176" mass="18049" checksum="013B8E57ED727462" modified="2019-05-08" version="1" fragment="single">NGGISVESLYIVIDLGLVGIAVESLYIVIDLGLGGLSDESLYIALDLGLAMLSAEIVYIVIGLGAGGSSVEAVKTVIDLGLGGPSAEVLYIVIDLDLGGLSVESLYSVIDLGLGALSIGALYITVGLGFAGLSVESLYIVIDLDMGALSEEALRIQISLDLDALSLSLLKIFKFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TIE2</accession>
    <name>A0A433TIE2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_010901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000343">
        <property type="protein sequence ID" value="RUS81334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TIE2"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS81334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="379" mass="41949" checksum="033C121E2E6DD123" modified="2019-05-08" version="1">MALSFAEVIPIAFYSLFAFIIITILVRIKAHAVPLYDSKGYAEDDMYQVVLYCAEDVKFPRRVYLCSDSSNACSPDKQRDQQRYHGQNQTSERKNTARNRSSPLAEDRSPLISSGNTSSESVYHSDLSRRESQIYNANDSSSGSPQYFENTSYNRHGRAMLRKKVRFSNQYRQNDPAKLTGRPFCHAPVQSGEKQTKLLASKVLKHKNPHDDVARNMRTSRTNFHEKACTLGEREVRRSCDEKQEKAEVKTTPSNVVKAPGCFPSCAALNGECANTVRKLATSSPPKKARPIGQPAQSPTAAGNAAKPTSNTLDSGVKLDGLEMVVKEISKKRTPPLTSLKTEGTEALQHAGDPGVSHIEEQQQEQCASAQKDGEKPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TIJ7</accession>
    <name>A0A433TIJ7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="30">Phospholipase ABHD3</fullName>
            <ecNumber evidence="3">3.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="31">Abhydrolase domain-containing protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="35" type="ORF">EGW08_010801</name>
    </gene>
    <organism evidence="35 36">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="35 36" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="35">EC2010</strain>
            <tissue evidence="35">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="29">Phospholipase that may play a role in phospholipids remodeling. May selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 activity, cleaving preferentially acyl groups in sn1 position. In parallel, may have a minor phospholipase 2 activity acting on acyl groups in position sn2. In addition to (C14)-containing phosphatidylcholines, may also act on other medium-chain-containing and oxidatively truncated phospholipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1-tetradecanoyl-sn-glycero-3-phosphocholine + tetradecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54456"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30807"/>
            <dbReference type="ChEBI" id="CHEBI:45240"/>
            <dbReference type="ChEBI" id="CHEBI:64489"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:54457"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O = 2-tetradecanoyl-sn-glycero-3-phosphocholine + tetradecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54404"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30807"/>
            <dbReference type="ChEBI" id="CHEBI:45240"/>
            <dbReference type="ChEBI" id="CHEBI:131738"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:54405"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>1-O-hexadecyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O = nonanedioate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54552"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64496"/>
            <dbReference type="ChEBI" id="CHEBI:78208"/>
            <dbReference type="ChEBI" id="CHEBI:138269"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:54553"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O = 5-oxopentanoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40483"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16120"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:77890"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:40484"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O = 9-oxononanoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:61042"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:77812"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:41180"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O = glutarate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41159"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30921"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:77756"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:41160"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O = nonanedioate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41388"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:78207"/>
            <dbReference type="ChEBI" id="CHEBI:78208"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:41389"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:73858"/>
            <dbReference type="ChEBI" id="CHEBI:75220"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:54409"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>1-octadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + H2O = hexanoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54464"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17120"/>
            <dbReference type="ChEBI" id="CHEBI:73858"/>
            <dbReference type="ChEBI" id="CHEBI:138212"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:54465"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>1-octadecanoyl-2-nonanoyl-sn-glycero-3-phosphocholine + H2O = nonanoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54472"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32361"/>
            <dbReference type="ChEBI" id="CHEBI:73858"/>
            <dbReference type="ChEBI" id="CHEBI:138214"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:54473"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>1-octadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + octanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25646"/>
            <dbReference type="ChEBI" id="CHEBI:73858"/>
            <dbReference type="ChEBI" id="CHEBI:138213"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:54469"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>1-octadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O = pentanoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:31011"/>
            <dbReference type="ChEBI" id="CHEBI:73858"/>
            <dbReference type="ChEBI" id="CHEBI:138211"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:54461"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>1-tetradecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + tetradecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54400"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30807"/>
            <dbReference type="ChEBI" id="CHEBI:76085"/>
            <dbReference type="ChEBI" id="CHEBI:86162"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:54401"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>1-tetradecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + tetradecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54396"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30807"/>
            <dbReference type="ChEBI" id="CHEBI:76079"/>
            <dbReference type="ChEBI" id="CHEBI:86102"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:54397"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = 1-tetradecanoyl-sn-glycero-3-phosphocholine + (9Z,12Z)-octadecadienoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54392"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:64489"/>
            <dbReference type="ChEBI" id="CHEBI:86094"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:54393"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + tetradecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54388"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30807"/>
            <dbReference type="ChEBI" id="CHEBI:76084"/>
            <dbReference type="ChEBI" id="CHEBI:86094"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:54389"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15802"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="35">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.4" evidence="3"/>
    <dbReference type="EMBL" id="RQTK01000338">
        <property type="protein sequence ID" value="RUS81417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TIJ7"/>
    <dbReference type="STRING" id="188477.A0A433TIJ7"/>
    <dbReference type="OrthoDB" id="247542at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008126">
        <property type="term" value="F:acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006650">
        <property type="term" value="P:glycerophospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051792">
        <property type="term" value="P:medium-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000079">
        <property type="entry name" value="Abhydrolase domain-containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012020">
        <property type="entry name" value="ABHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF63">
        <property type="entry name" value="ALPHA_BETA HYDROLASE 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005211">
        <property type="entry name" value="Ab_hydro_YheT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 33" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="36" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 33" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 33" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="34">
        <location>
            <begin position="123"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="32">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="32">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="32">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00050145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00050182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00050195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00050276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00050674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00051164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00051705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00052087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00052144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00052588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00052747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00052808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00052894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00059841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00071303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00082158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="PIRSR" id="PIRSR005211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="EMBL" id="RUS81417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="394" mass="44497" checksum="5D52BA9F20283E4B" modified="2019-05-08" version="1">MDMYADYVSPLLENHMGIVVAAVLFILYIAYYLLFVVKYPVIACGDSKYKQFLEDHCPIAKEKFWPTWWAFEGRVQTLLRALIQSCPQVDYVGELIKCPDGGLIKLDWVENDDNGKHSKETRPTILMLPGLTGNSMESYILHMVEDVTALGYRSVVFNNRGTCGTPLKTPRTYCAANTEDTALVIDHIKEKYPEAPVMAIGISLGGMILFNYMAHNGKDARLDAAMCISANWHITKGTKSLESPINYHLFNRILAKALCCLVEKHSHVFEKHADLKIPHVLESQSIRDFDERFTSKVFGYESVDHYYDHASLHTKVHALGKPVLCLNAGDDPFSPANTIPLEDAEKNDNIAIVMTSHGGHIGFMEGAIPRHRSYMYRWVRQFVPAVFEHGIKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TK74</accession>
    <name>A0A433TK74_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_010317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000314">
        <property type="protein sequence ID" value="RUS81931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TK74"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS81931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="139" mass="15177" checksum="5AF4E791E3E2D9FA" modified="2019-05-08" version="1" fragment="single">TVNQLHVACSSHVTVNQLHVACSSHVTVNQLHVFISCNSQPTTCSMFISCHSQPTTCSMFMSCHSQPTTCSMFISCHSQPTTCSMFISCHSQPTTCSMFISCHSQPTTCSMFISCHSQPTTCSMFISCHSQPATCSMFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TKB6</accession>
    <name>A0A433TKB6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_010239</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000309">
        <property type="protein sequence ID" value="RUS82012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TKB6"/>
    <dbReference type="STRING" id="188477.A0A433TKB6"/>
    <dbReference type="OrthoDB" id="10248446at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001235">
        <property type="term" value="P:positive regulation of apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02413">
        <property type="entry name" value="KH-II_40S_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1140.32:FF:000005">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.20:FF:000006">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="entry name" value="Ribosomal protein S3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057258">
        <property type="entry name" value="Ribosomal_uS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_uS3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_uS3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005703">
        <property type="entry name" value="Ribosomal_uS3_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003219">
        <property type="entry name" value="PRK04191.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01008">
        <property type="entry name" value="uS3_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760:SF32">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="Ribosomal protein S3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="9">
        <location>
            <begin position="52"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="226"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS82012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="284" mass="31191" checksum="A622F5EA86A7C5FA" modified="2019-05-08" version="1">MYVFNEGISLAYIKPNPEQLIFLFCEEPHTIMATQQSKKRKFVADGIFKAELNEFLTRELAEDGYSGVEVRVTPTRTEIIILATRTQNVLGEKGRRIRELTSVVQKRFGFPEGTVELYAEKVATRGLCAIAQCESLRYKLIGGLAVRRACYGVLRFIMESGAKGCEVVVSGKLRGQRAKSMKFTDGLMIHSGEPLNDYVDTAVRHVLLRQGVLGIKVKIMLPWDPTGKTGPRRPLPDHVSIVEPKEETPVTQPYSEAKGAKPTDAAAAPPVMGGPGVPAPVPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TLY6</accession>
    <name>A0A433TLY6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Matrix-remodeling-associated protein 7 helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_009695</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000281">
        <property type="protein sequence ID" value="RUS82565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TLY6"/>
    <dbReference type="OrthoDB" id="5983600at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026622">
        <property type="entry name" value="Mxra7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057534">
        <property type="entry name" value="MXRA7_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21845:SF2">
        <property type="entry name" value="MATRIX-REMODELING-ASSOCIATED PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21845">
        <property type="entry name" value="TRANSMEMBRANE ANCHOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25473">
        <property type="entry name" value="MXRA7_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Matrix-remodeling-associated protein 7 helical" evidence="3">
        <location>
            <begin position="112"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS82565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="174" mass="19524" checksum="6C556FF9EE904A9C" modified="2019-05-08" version="1">MGYQQILNFSDVASLGIFVFTSVVTIIALAISTRYVLKKIFSKNSGAETKQVPMKGKTAPSPPDVTVDDNSDEEEVDLDKDGSGKSGDSPPVLSPRYPDPVDYCEHIQGEIKRVQQKVATKSIAKTLTEDQLKEEREIQREQLATIFRLMQEQQDRFGIGTMDDMQEQMKLYAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TPX9</accession>
    <name>A0A433TPX9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_008662</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000239">
        <property type="protein sequence ID" value="RUS83556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TPX9"/>
    <dbReference type="STRING" id="188477.A0A433TPX9"/>
    <dbReference type="OrthoDB" id="9000293at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000029">
        <property type="entry name" value="Acetylcholinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF12">
        <property type="entry name" value="ACETYLCHOLINESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="72"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="562"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="506"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600997-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS83556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="873" mass="94956" checksum="222CB36EE9AEF1A2" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TQD9</accession>
    <name>A0A433TQD9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase M12B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_008404</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000228">
        <property type="protein sequence ID" value="RUS83823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TQD9"/>
    <dbReference type="STRING" id="188477.A0A433TQD9"/>
    <dbReference type="OrthoDB" id="6145095at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.70.10:FF:000003">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051489">
        <property type="entry name" value="ADAM_Metalloproteinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702">
        <property type="entry name" value="ADAM10/ADAM17 METALLOPEPTIDASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702:SF2">
        <property type="entry name" value="KUZBANIAN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13574">
        <property type="entry name" value="Reprolysin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019176564" description="Peptidase M12B domain-containing protein" evidence="4">
        <location>
            <begin position="26"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="6">
        <location>
            <begin position="316"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="5">
        <location>
            <begin position="548"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="266"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="266"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="478"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS83823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="754" mass="84163" checksum="4BCB6FBE01896F3B" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TQH4</accession>
    <name>A0A433TQH4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_008343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000226">
        <property type="protein sequence ID" value="RUS83862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TQH4"/>
    <dbReference type="STRING" id="188477.A0A433TQH4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS83862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="164" mass="17368" checksum="C51F1FAA784C4BD2" modified="2019-05-08" version="1" fragment="single">TYSTIVSVCNTCTYSRIVSVCNTCTYSRIVSVCNTCTSSRIVSVCNTCTSSRIVSVCNTCTSSRIVSVCNTCTSSTNMSVCNTCTSSRIVSVCNTCTSSRIVSVCNTCTSSRIVSICNTCTSSRIVSICNTCTSLRIVSVCNTCTYSRIVSVCNTCASSRIVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TRE6</accession>
    <name>A0A433TRE6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTCK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_008108</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IL-17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000217">
        <property type="protein sequence ID" value="RUS84134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TRE6"/>
    <dbReference type="OrthoDB" id="6093654at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010345">
        <property type="entry name" value="IL-17_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06083">
        <property type="entry name" value="IL17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019242159" description="CTCK domain-containing protein" evidence="6">
        <location>
            <begin position="30"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS84134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="21502" checksum="1F3658A13921E910" modified="2019-05-08" version="1">MSQFKLTHLTYLTYLLYILMAALLSCCDGSGGAVGGAQAACAEPANLMDLYRDLREQQIAASSIMEEPSTAAYTSAQGSSSRSSSSNRTITKLAGHHHNNAQSSAFSGICRCQATDELNHDPTRIPRIIPQSSCRPHRPWRTLVYSAECEEVYTPVKIKRRTGCLNGVYQYSDAWESVAIGCKCQVYRRIVVTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TSJ5</accession>
    <name>A0A433TSJ5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_007714</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000202">
        <property type="protein sequence ID" value="RUS84545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TSJ5"/>
    <dbReference type="OrthoDB" id="6286464at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="369"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="430"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="459"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="302"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS84545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="509" mass="54940" checksum="16638AB852836E55" modified="2019-05-08" version="1">MRSDGIFFLQFLDRFNQNKQLTAWPGAVSFTLQCLVAPAATAFCNRFSVRTAVHLGTFLLTSGLVMSAFSPNIYFLFLSYGVVQGIGRGLIIVPGIFIVNMYFSKRLGIALGFASSGTGIGTLGLPPLITWLFDTLGYQGAHLTVAGIATCGWVVAMLFRPLSMHKNIVRHRMLKAKIASRTCQTPDVEYRIQSNCYSRYGTIKSAQSDTPNLTSTSGYCTETENESSLNHTISIKTTSHQTKNTPDGLYNAIAKIEDTRLRRKRRNCCVAVIDNIFPIEEEKRGEKGKRILLHWPLFRDFPFLVLCVSMAFFNLAQKTVFTFLPAYARQRGIAGGSLVLSAAGAGDTVGRVVAGLVLDRAAVKPHKGAVYALVLIFAAAAAWAVPFSYSLLPLCAAGCVYGFSVGASVSQKSNVLATLLGKETVNSAFGILYAFQGIGTMAGLPISGALRDAFGNYDFAFYLSSGSMYSAGALVALSVLLFAMRRRRREGGAGRHGYETLPTGGGSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TSN4</accession>
    <name>A0A433TSN4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Actin, cytoplasmic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_007646</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000200">
        <property type="protein sequence ID" value="RUS84619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TSN4"/>
    <dbReference type="STRING" id="188477.A0A433TSN4"/>
    <dbReference type="OrthoDB" id="10249208at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000131">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS84619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="376" mass="41983" checksum="30458413BB7885CD" modified="2019-05-08" version="1">MCDDDVAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNCPAMYVSIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMQTAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPNFLGMETVGIHETTYNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITSLAPQTMKIKVIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TTT8</accession>
    <name>A0A433TTT8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibrinogen C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_007272</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000187">
        <property type="protein sequence ID" value="RUS84961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TTT8"/>
    <dbReference type="STRING" id="188477.A0A433TTT8"/>
    <dbReference type="OrthoDB" id="7972392at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018972437" description="Fibrinogen C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="3">
        <location>
            <begin position="319"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS84961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="523" mass="57281" checksum="26A7AC7DAB898BBA" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TV52</accession>
    <name>A0A433TV52_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carbonic anhydrase</fullName>
            <ecNumber evidence="4">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_006747</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="RQTK01000168">
        <property type="protein sequence ID" value="RUS85471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TV52"/>
    <dbReference type="STRING" id="188477.A0A433TV52"/>
    <dbReference type="OrthoDB" id="5978072at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018338">
        <property type="entry name" value="Carbonic_anhydrase_a-class_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF208">
        <property type="entry name" value="CARBONIC ANHYDRASE XA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00162">
        <property type="entry name" value="ALPHA_CA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025091997" description="Carbonic anhydrase" evidence="4">
        <location>
            <begin position="26"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="5">
        <location>
            <begin position="30"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS85471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="327" mass="37153" checksum="EEF293936E3D7F49" modified="2019-05-08" version="1">MSLLGMLGYFVAVWTFVTVWHGAESSRWHTWWSYDSGISGPRYWGMLNPHWSLCKKGRNQSPVNIEPKALLFDPSLNSLEIKGNAITGMLANMGYSLTLDVDLGSHWSHGVNISGGPLSYTYRVFQLRVHFSHSDTDGSEHTVEGRGFSSELHIFAFNSDLYENITSAMTSPRGILCMAIFLKVSNATNPHFERIHRALDDVLYKGDKREVSYLELRGLLPQTDHYMTYEGSLTHPACHETVTWVIYNKPVYISSTQIAGLRRLKQDTKSNPVLLMAGNIRPVQSLNQRTIRTNINLGEGACSMERDINYAVNHNYFQYQRESYSFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TVR8</accession>
    <name>A0A433TVR8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_006644</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000164">
        <property type="protein sequence ID" value="RUS85632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A433TVR8"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.180.10:FF:000032">
        <property type="entry name" value="Fasciclin domain-containing protein, putative"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="173"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="206"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="346"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="1255"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="1394"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="439"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="555"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="636"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1120"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="474"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="636"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="685"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="766"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="795"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="852"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="868"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1026"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1120"/>
            <end position="1157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS85632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1531" mass="167120" checksum="15340AD5C28BFB7C" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TWU5</accession>
    <name>A0A433TWU5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_006210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000152">
        <property type="protein sequence ID" value="RUS86056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TWU5"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS86056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="241" mass="28562" checksum="A0CAA353723A46FB" modified="2019-05-08" version="1">MRGLVLERDGAWERERASEEGSNMGTLKLSVHVEEKVKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKNKNKNKNKKNKNKNKNKKNKNKNKNKKNKNKNKNKKNKNKNKNKKNKNKNKNKKNKNKNKNKKNKNKNKNKKNKNKNKNKKKRKKEKDEESIFYMSTTPPSDVKTYPLRGQTKNVAVGSVLKRHEKRGEGIIRRKNSGNVTRPPERIQHLYSHSASGLQQSCPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TXI9</accession>
    <name>A0A433TXI9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_005909</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000142">
        <property type="protein sequence ID" value="RUS86324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TXI9"/>
    <dbReference type="STRING" id="188477.A0A433TXI9"/>
    <dbReference type="OrthoDB" id="6072453at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="66"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="343"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS86324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="386" mass="43780" checksum="95BE31D94F816704" modified="2019-05-08" version="1">MSNKSESDAGPDPFLAARGSLFDFSQMAAVDWDDIHNGEQLIPRAYTSWNALNIVRLGLSIWIICSHIAIIVFILGKQILRTQPKNLLIVNVALVNMLLGVFVIPGKLHFILNPSHVPCNLAVAWDFIANYFQPSVALFAVLSLVFERFVYVYTEKRQRKIKPLAQILGTIVLLVVPWLISTLFLLPIYFGGLVAKARDPNMCLYKTDDHFFVATQLISFIPPSLGVFILAPFTGLLDCLRPKRCFYKPLTPKGESMTVTTVVTLFSIFAEAPFCIVRVLMMRLECNTPDCTRFSETLTVTWWVRIIKTAVFPFVWLFYTDIRDAMGCQMDFRMSDVDLDSDEEDGFELKQPEPQTLKHTESKESDESEIETRYAKVHFAPTPSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U2K3</accession>
    <name>A0A433U2K3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_004192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000094">
        <property type="protein sequence ID" value="RUS88026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U2K3"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS88026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="331" mass="35113" checksum="5AAAD06168B94395" modified="2019-05-08" version="1" fragment="single">VQQIQAVSSSPSEAQPTAAIKEESAAVSSDQGKDKKADSGSEDSNSDSSSSDSDNDNEEKENDKEVAKSDQQEDTDKDDVLALLASQVTEEKKEEEERNSAREQKEEAGAKEAKKEDGEQERKASVVPSVTVSNHASDSSSGDSSDDSNSSGDESDDESRKKGKVSTKNGVIHTEADVHNSDGKHAGKIGSIDSDSEAMHGGNDPDKVADSVDGSLPEPVPVQATVAKVKPGSIQPLLEKSRCMVEIKGVTLNKSQLYECANHIATHGQINQINLVNCGLDDDDLQKVTEALKQSPSNPVLLNLSLNPLSSACVDYLLDLLDSKPSIEAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U414</accession>
    <name>A0A433U414_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Piezo non-specific cation channel cap domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_003704</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000080">
        <property type="protein sequence ID" value="RUS88528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U414"/>
    <dbReference type="STRING" id="188477.A0A433U414"/>
    <dbReference type="OrthoDB" id="303066at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071260">
        <property type="term" value="P:cellular response to mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050982">
        <property type="term" value="P:detection of mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027272">
        <property type="entry name" value="Piezo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031334">
        <property type="entry name" value="Piezo_cap_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13167">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13167:SF25">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12166">
        <property type="entry name" value="Piezo_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019006110" description="Piezo non-specific cation channel cap domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo non-specific cation channel cap" evidence="2">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS88528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="113" mass="13441" checksum="C624AAE714123CA5" modified="2019-05-08" version="1">MYVSFVLVLFKFFRTAFIDGRMVLVYVEELPCVDHLLVLFDQMFMAREMKDYWLEEELVAKLIFILRSPDVLFRITRMPQEVAKPPSGTSNKKNRFTALYNLYDQIQGTSLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U479</accession>
    <name>A0A433U479_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_003596</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000077">
        <property type="protein sequence ID" value="RUS88637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U479"/>
    <dbReference type="STRING" id="188477.A0A433U479"/>
    <dbReference type="OrthoDB" id="6162636at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS88637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="126" mass="13858" checksum="7CAC0886EE5195D7" modified="2019-05-08" version="1">MGFTDYGLTDYGLTDYGLTDYGITDYGITDYGLNDYGLTDSGITDYGLTDYGITDYGLTDYGITDYGLNDYGITDYGITDYGITDYGITDYGITDYGITDYGITDYGITDYGITDYGITDYGIRAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U683</accession>
    <name>A0A433U683_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EGW08_002917</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">EC2010</strain>
            <tissue evidence="16">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the splicing factor SR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000059">
        <property type="protein sequence ID" value="RUS89310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U683"/>
    <dbReference type="STRING" id="188477.A0A433U683"/>
    <dbReference type="OrthoDB" id="423462at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089701">
        <property type="term" value="C:U2AF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12538">
        <property type="entry name" value="RRM_U2AF35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000055">
        <property type="entry name" value="Splicing factor U2AF 35 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009145">
        <property type="entry name" value="U2AF_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12620">
        <property type="entry name" value="U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01848">
        <property type="entry name" value="U2AUXFACTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="15">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="14">
        <location>
            <begin position="65"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="15">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="12">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="12">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="197"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="201"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RUS89310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="250" mass="29761" checksum="1161C0BE6FC9495F" modified="2019-05-08" version="1">MAEYLASIFGTEKDKVNCSFYFKIGACRHGDRCSRLHNRPTFSQTILLQNLYLNPQNAALTADGSHIMMDDVQAQQEYDEFFEEIFVELEDKYGEIEEMNVCDNLGDHLVGNVYVRFHREEDAEKAVADLNNRWFNQRPIHCELSPVTDFREACCRQYEMGECTRGGFCNFMHLKPISRELRRELYGRSGRRRGSNRRWVHLKDERESRSRSPPPRDNRRDRERGDRRDRDRGGRDRKRSRSRDNRHGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U6K3</accession>
    <name>A0A433U6K3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Anaphase-promoting complex subunit 15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_002776</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the APC15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000055">
        <property type="protein sequence ID" value="RUS89479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U6K3"/>
    <dbReference type="STRING" id="188477.A0A433U6K3"/>
    <dbReference type="OrthoDB" id="6362917at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090266">
        <property type="term" value="P:regulation of mitotic cell cycle spindle assembly checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026182">
        <property type="entry name" value="ANAPC15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22526">
        <property type="entry name" value="ANAPHASE PROMOTING COMPLEX C SUBUNIT 15, PSEUDOGENE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22526:SF2">
        <property type="entry name" value="ANAPHASE PROMOTING COMPLEX C SUBUNIT 15, PSEUDOGENE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15243">
        <property type="entry name" value="ANAPC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="49"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="62"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS89479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="11731" checksum="A14DCC27817B28F5" modified="2019-05-08" version="1" fragment="single">MSNPFFPSTLPKVGDPLWFNVDKPTDDENELSHLEKKHQAWMDAIAQKDSNIVPIGKSSEHLEEEEEEEDEEECEEEEESDTNDDPDTDMMDERDSNDEASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U6V0</accession>
    <name>A0A433U6V0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_002694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000052">
        <property type="protein sequence ID" value="RUS89576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U6V0"/>
    <dbReference type="OrthoDB" id="10592093at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS89576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="474" mass="50725" checksum="E157BF62C455F06E" modified="2019-05-08" version="1">MRKSLQRAIPGAMSLPDVMMLDTGRAGEQLSLPDIAKAQSFAGRVSHSHDQPHDTDQPSGHSSDCPYCCQAVYPIMPINFLSDSSCSECIREREVKAEQEALRVKVMRSLPASRKFGAVVSSSVDGEGEEEGAQRNASFCESHRAAVLSSLPEDGCRPEGDTSAHPTSERAAPSSGSDAISSRPGSLCHKHADEASRSSSKADDKRASGEPSSLTSKSSSGRRGEHPPLKSMSSSSSGRSADAPHAPHAQGHRKLAGDTPRLSSSLRSSSAGSSVKSKLPLQQSSSLDVPTRNSRPSSPADMIHLRRPKSHAGVNNNDDYDDDDRSDESNDDGDCTGLLPSTLRTETTTDDFGFSSMPSNPTETMLVSEPAAQQQNCREEIRQGFPGTQTEVLPGAVWRQREIWHGKSREILGRRVWSPAARCKEEQQGGSVVWPRPVQGAQPRDGGDAKQSQSAQGRGGVRGGTSRGRDFCGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U734</accession>
    <name>A0A433U734_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_002650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000051">
        <property type="protein sequence ID" value="RUS89632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U734"/>
    <dbReference type="OrthoDB" id="5957813at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS89632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="377" mass="42247" checksum="9D868C15F2792946" modified="2019-05-08" version="1" fragment="single">MSTPKTRSSQKTAMDNAFFTARSTMRQCLVITSCPPFLATTMLMILGLVLLLEEVILVPGGLNIPEPVKREIPEVDSPNVIYSKRISSFWKVEDFIVQKGPMRIPRRNTSFKSKNYKDSGFVLDQNVSFPLEQTNSKTGKGDNWEEESNQMAAVKSSTMDNTQNAKLGDSEINLKGGAVLKYRSSKTHHNALPVADTDDKGQTSQQTTASNAIQRKKTDKDQASHHITPSNGQRKEPDSEQQIILSNDRPKKSDKELTSRQIPSSNDLSKKPEKVLDPPRGSQGQRPARLRGKGLGDDNSYSVPSSKHRARLLDRVVDQFRLGKDEPRDSFINLHRYGYVLDSDACNTGNPKFAILIHSKFNNFIKRAKIRNTFAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U7Q2</accession>
    <name>A0A433U7Q2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_002436</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000047">
        <property type="protein sequence ID" value="RUS89824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U7Q2"/>
    <dbReference type="STRING" id="188477.A0A433U7Q2"/>
    <dbReference type="OrthoDB" id="6081913at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000036">
        <property type="entry name" value="CYtochrome P450 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF403">
        <property type="entry name" value="CYTOCHROME P450 306A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="497"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS89824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="554" mass="63638" checksum="F0C4A50117C95725" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U9W8</accession>
    <name>A0A433U9W8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_001600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000028">
        <property type="protein sequence ID" value="RUS90603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U9W8"/>
    <dbReference type="OrthoDB" id="10676164at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS90603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="166" mass="18182" checksum="0FE444D31B54DAAB" modified="2019-05-08" version="1">MGDEVVSPGALEVSRTNGSVLALSFSAHRSISKLSTKTGLHESKSALDNEHTERIEEEEDIQNAGRSSDGEEEKVPEPPYIPPPINFIRTEFNDSPPILVNHNCIKKTFVDFMNRKIGKSIGLVAKNKSTDEKWSGTAFTWNSQIGVGKSADPKAKETSGEKKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UE70</accession>
    <name>A0A433UE70_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_000010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000001">
        <property type="protein sequence ID" value="RUS92157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UE70"/>
    <dbReference type="OrthoDB" id="6107663at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS92157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="209" mass="22858" checksum="ED1F1BDED712715A" modified="2019-05-08" version="1">MPPVRKSCPSGTKLTVATLFWILSYLVSLGLAVASLITECWIRWKEEVTQSNHCYGIFLSGTSTDRKPCELEAVVRETGKELFKDFDLHSMVALMILGIGFDTLTVSTGLLYFFAKGKAKTSLWKRSIPTLTLGLISAGMVFLAFLIFIDDLEKVTDSQVNAFVDERCTTRLDEVNLLPSTGFSVYLALAAGTTVLLKTGTFGCLAACC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z4A8</accession>
    <name>A0A3S0Z4A8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_021871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001425">
        <property type="protein sequence ID" value="RUS70369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z4A8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS70369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="202" mass="21359" checksum="A65D8D6C3B2D9CF7" modified="2019-04-10" version="1">MWSQCGIYKDRDRGLPRLYLKSILRFLEFSAVPTHTCSMPRGQTVLSLCVFISARVVFLAVSGAWFFGSHIMDKMDSVEALQPSVCLCVGDGYQVSSADICVWCVGDGYQVSSAAICGWCVGDGYQVSSADICGWCVGDGYQVSSAAICGWCVGDGYQVSSAAVCVWCVGDGYQVSSADICVWCVGDGYQVSSAAIGVCGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z6U9</accession>
    <name>A0A3S0Z6U9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_020280</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001135">
        <property type="protein sequence ID" value="RUS71967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z6U9"/>
    <dbReference type="STRING" id="188477.A0A3S0Z6U9"/>
    <dbReference type="OrthoDB" id="10249149at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000022">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000002">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="8">
        <location>
            <begin position="49"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS71967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="318" mass="35303" checksum="95EB6C0BDC8761D5" modified="2019-04-10" version="1" fragment="single">MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDLVLDRIRKLSDQCTGLQGFLIFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z8X3</accession>
    <name>A0A3S0Z8X3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_020158</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001117">
        <property type="protein sequence ID" value="RUS72076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z8X3"/>
    <dbReference type="STRING" id="188477.A0A3S0Z8X3"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF516">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS72076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="56418" checksum="FD84A6B1CACED1D7" modified="2019-04-10" version="1">MGRYKRNGFALAAQEEEITGSTDHQKRLARPSLDSQSQSELQTPEVVIETGTLRRSITLFGAVAILIANIGGTGIFITPTMILRFSGSPGLSILIWMLGGIVQAAYAFCTVEIALMFNKAGGPYFFIYSSFGDIAGFVYMWGFVIFIVGPSWALGSYTASLYTLSVFFTDCQPSDFLVKLVALWLMITLMAINSTYMKVTTSIQSFLTSCKMIALVIIIVSGLILVPSETGQENLSSFMDGSTTNIGNIALGLFAGSYGFGGWQVITVLAEEVKDPVRNIPRSLGFVFVLLILVMTATNFAYYVVLSKTEALKSEAVAMLFGQMIHPWIPVIMSVLVSLCAIGTLNVLIMGQPRVLFAAGRNGHMPRIMTMLHRTYNTPWPATWTLGLVASFLLLTGSVMSLVAAISLYFGSSAILLTVSIFVLRWKHPDKHRPFRIPTVIPILVFIVMTTIVTMSIYEKPLTLVSNLITILLGVPIYLVFFKCKAVRKRLHFMDRIGYFLERSFLLQYET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZFC6</accession>
    <name>A0A3S0ZFC6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_018598</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000914">
        <property type="protein sequence ID" value="RUS73643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZFC6"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="632"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS73643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="693" mass="76587" checksum="5C1CC4553D442BAD" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZFM1</accession>
    <name>A0A3S0ZFM1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_018437</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000898">
        <property type="protein sequence ID" value="RUS73798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZFM1"/>
    <dbReference type="STRING" id="188477.A0A3S0ZFM1"/>
    <dbReference type="OrthoDB" id="10030037at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045329">
        <property type="entry name" value="LZTS"/>
    </dbReference>
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            <end position="152"/>
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            <end position="152"/>
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            <position position="1"/>
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    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
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            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS73798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="331" mass="38696" checksum="525AA075D86EF35D" modified="2019-04-10" version="1" fragment="single">LQTPSPSDSGVGEHEAILREKDAEINTLREVMDRNERAIFQVYEERRHVWLNDTRKLQDEYERKLKIQSRKSYKTEQVLSLQVYKLQQEQKSLQEDKVKVTQELDALKQRLEEEQAEAYNLRKQLGNHSSSPGRDHQEDQKAVSNEGSPQSLQREVLLKNEEITQLRLQLACFEDDLNKANRDLKEKVREIANCNDKIKSLEEEMHKSKSLPQSTETGSQINAAASQVVATENSQRPSLLGQQERTIDELQEETTSLRAHIEELKVKQEEERKQWLDEKNKVVRYQKQLQLNYVQMQRKNTTLETEVQQLTLELENRDMKLTALNGEESVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZGW9</accession>
    <name>A0A3S0ZGW9_ELYCH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_013581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
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            <taxon>Sacoglossa</taxon>
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            <taxon>Plakobranchidae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000497">
        <property type="protein sequence ID" value="RUS78654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="6161047at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="86"/>
        </location>
    </feature>
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            <end position="145"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="283"/>
        </location>
    </feature>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="32"/>
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            <end position="1001"/>
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        </location>
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    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS78654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1128" mass="115769" checksum="8AEFD63803226D44" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZH46</accession>
    <name>A0A3S0ZH46_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_013467</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000490">
        <property type="protein sequence ID" value="RUS78783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="188477.A0A3S0ZH46"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Teneurin transmembrane protein 2"/>
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    </dbReference>
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        <property type="entry name" value="Galactose-binding domain-like"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR058727">
        <property type="entry name" value="Helical_Vwde"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23106">
        <property type="entry name" value="EGF_Teneurin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="1 2">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS78783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="304" mass="32228" checksum="18D1721931C9ABC6" modified="2019-04-10" version="1" fragment="single">MDGPQGGVDPTNEAQIRQKCSQAVHQSVMIGLCKDMDALLETTIDECVDDFLVTGDDMIVETSVHTFNMLCQTELEKNPQNYVVGADGIKELNDNVTAKATCTQTCSNHGVCQNGACVCDPGWMGNHCAINMNGTNVNGTTAAPMITTTTALVGINASLTMNATTPPTPKDQMCDVSVKNCSSLDLPAPTGTSPGDAVNCRFDIPQQKRVVTTGVITKSGMCECPVPNLYVGRNIGAAYVEMSVTCESGNGLGPVQQLVLYDSRCVDSNLTQAARVCIIESLCYGDGFMNPINDYEGCSPVQNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZI64</accession>
    <name>A0A3S0ZI64_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dynein heavy chain region D6 P-loop domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="4 5">
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            <taxon>Sacoglossa</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000744">
        <property type="protein sequence ID" value="RUS75420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="188477.A0A3S0ZI64"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000153">
        <property type="entry name" value="Dynein axonemal heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000005">
        <property type="entry name" value="Dynein axonemal heavy chain 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000005">
        <property type="entry name" value="Dynein axonemal heavy chain 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000006">
        <property type="entry name" value="Dynein axonemal heavy chain 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF63">
        <property type="entry name" value="DYNEIN AXONEMAL HEAVY CHAIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain region D6 P-loop" evidence="1">
        <location>
            <begin position="115"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA lid" evidence="2">
        <location>
            <begin position="259"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain C-terminal" evidence="3">
        <location>
            <begin position="416"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS75420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="715" mass="82731" checksum="DB71EDBF7FCFBC7C" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZI67</accession>
    <name>A0A3S0ZI67_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_012798</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000450">
        <property type="protein sequence ID" value="RUS79457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZI67"/>
    <dbReference type="STRING" id="188477.A0A3S0ZI67"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="99"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS79457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="148" mass="16538" checksum="4AB6A1FD7F14F71B" modified="2019-04-10" version="1">MKKKSGSKKRGKKSGKGSKKSTKDAEDKADGFENADPSTLISGDVASPGGKKGKKKGKKKKLSKSEKATEKLEKQVEKLRADVCYYDRFINRMHQWLLDNAEAAVEMFRHIDSDGEGLLSFDEFKSGDHHVCATEGIVHNVVRFFFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZIP1</accession>
    <name>A0A3S0ZIP1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Lariat debranching enzyme C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_012397</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000425">
        <property type="protein sequence ID" value="RUS79833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZIP1"/>
    <dbReference type="STRING" id="188477.A0A3S0ZIP1"/>
    <dbReference type="OrthoDB" id="407609at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008419">
        <property type="term" value="F:RNA lariat debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00844">
        <property type="entry name" value="MPP_Dbr1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007708">
        <property type="entry name" value="DBR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041816">
        <property type="entry name" value="Dbr1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849:SF0">
        <property type="entry name" value="LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849">
        <property type="entry name" value="RNA LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05011">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01124">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lariat debranching enzyme C-terminal" evidence="11">
        <location>
            <begin position="184"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="342"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="401"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="342"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS79833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="481" mass="53222" checksum="4B2A16642C6DB3C2" modified="2019-04-10" version="1" fragment="single">MAVPQKYQQLNTFYKYYSGEKTAPVLTVFIGGNHEASNYMQELPYGGWVARNIYYMGYAGIIQVGGVRIGGISGIYKGHDFNKGHFERPPYERDTVRSVYHVRNLEVFRLKQISRHTDIFISHDWPQGIYHNGDVDNLLRTKPFFKQEIEENKLGARPLADLLSHLQPSYWFAAHLHVKFAAHVQHKPGADGIPAKSTKFLALDKCLPRRNFLQVLDIPHNQEEGLKIKLDPEWLNILKSTDHLLKLTPGTVYMPGPGGRERYDFTVSDKEMKDIVATFGGDMTLPENFEQTSPPILGLPNQQMKFARRRPLCVQVNPQTTLLCTMLEVTDPNAKILGKTSQQLLDESSTSPAASLSGGSDDPHDEEEAEDSGKDFPSMIDSSIDISISSMSNSPLGDRSGWDSFHTANESLGDSRLSSPSSSSTPLKPSAGGVGNKASLTLPAPSIVSKVADDDEELLLILSAQKNKSLSKSPLKDLPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZK83</accession>
    <name>A0A3S0ZK83_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_022902</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001722">
        <property type="protein sequence ID" value="RUS69335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZK83"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00083">
        <property type="entry name" value="bHLH_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS69335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="29799" checksum="049776D9C499F777" modified="2019-04-10" version="1">MQAAFSRLDEAVPDHMKISEHKDGSKMSSIENAIHYIKYLYNEIKSNDANHDRSSDPKHQHLVNIPLKRNTGSEGVDVEVSSIGYAGSQHQVHAGIQGNQQTNQELANGHVNPVSHSLANGSNQNLEYSVSAVNPQSHTFANGPNQNLEYGVPHVNPMGQTFANGSSQNFSNGAPVVNPLSHTFANDPNKNLSNDAPMVNYLSQTFANGAINSINPYLANASIDPMNHTSSNETPAMNPLNYTNQSFGNGPVNSLSQNFDNGSKNYLNQTFNIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZRR2</accession>
    <name>A0A3S0ZRR2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_006964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000176">
        <property type="protein sequence ID" value="RUS85263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZRR2"/>
    <dbReference type="OrthoDB" id="6162458at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="928"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1012"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1063"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="530"/>
        </location>
    </feature>
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        <location>
            <begin position="552"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="615"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="702"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="757"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="778"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="798"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="811"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="851"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="952"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="974"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1012"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1063"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1086"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1104"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1114"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS85263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1151" mass="124778" checksum="B5E10FE4824472AF" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZS43</accession>
    <name>A0A3S0ZS43_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_018285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000882">
        <property type="protein sequence ID" value="RUS73947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZS43"/>
    <dbReference type="OrthoDB" id="6110259at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS73947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="40788" checksum="884EBC28C3312D8D" modified="2019-04-10" version="1">MDGSAMYTVKQTVEKEKCEEKRKSSNTHRAILARGIRGFHEVSYEGGTDLHNRLLDCPKYEDHSCFIPIQNFTQVDLPQGYRDPDIVNFVQAQGELTVRVVSNVTSKARPDGYAFHDFKGQERPRYGTGFIQYLYRDDVRSNKPCPCPECKASGVVHKKWYKIKVRTATHVVFNKEESLGTYVELYFDGFEGSTVKRFYGESLAFGAIQGDWCDIRCVSHDIELCEHIKDVWGRWRWLETKINHKYEDRDEEDHRLVVVVSHPHGCHKQVSVGRWRQRHVVDRCRGWENCVYTYDAPTCPGSSGAPIWILGRMKWAGFFGRHPHSGRPEEEEGGESVNLSGVGLDKKSDEPRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZST4</accession>
    <name>A0A3S0ZST4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EGW08_017874</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">EC2010</strain>
            <tissue evidence="15">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000838">
        <property type="protein sequence ID" value="RUS74365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZST4"/>
    <dbReference type="STRING" id="188477.A0A3S0ZST4"/>
    <dbReference type="OrthoDB" id="6022368at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017046">
        <property type="term" value="F:peptide hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050332">
        <property type="entry name" value="GPCR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02793">
        <property type="entry name" value="HRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00649">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="13">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="14">
        <location>
            <begin position="88"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="388"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="408"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RUS74365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="459" mass="52772" checksum="9C14D444B85B8DBE" modified="2019-04-10" version="1" fragment="single">VSTEPYCRPIWDGLACWPKTKGGDTAIIPCPTYVNEFLLAGKATKQCLANGQWFVHPFLNNTWSNYSACNEDQINLLFYVPQAHLHRIKLMYSTGYGISLFALGIAIFIMIYFKRLHCPRNTIHVHLFSAFVLRAFLSFLKDSLLVEHVGLPGDVTKVNGTLVFDPDASHWECKLLFTIFHYIVLTSAAWVFMEGLYLYILVTVTIFSERRYIRWCTILGWGGPLLFLVPWVVIRATVEDHLCWNTHPTTTIFWILKGPQIAITVVNFYFFIRITCVLFTKLVGTAPPRARKYRYRRLGKSTLVLIPIFGVHYLLTIGFPANIDPMVETIKLYFEMFFNSFQGVLIACLFCFMNGEVQSEIRKRYVRHKLRVNSRNFQNKLASTACSNMRQRTRPSSSPRAESRELQSSSGSDNASGSSERQKLKIYCQPLRYYRAQIPNGVADTRPFIYSAENKNSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZTN1</accession>
    <name>A0A3S0ZTN1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1771 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_006703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000166">
        <property type="protein sequence ID" value="RUS85560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZTN1"/>
    <dbReference type="STRING" id="188477.A0A3S0ZTN1"/>
    <dbReference type="OrthoDB" id="3231855at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052772">
        <property type="entry name" value="Endo/PolyKinase_Domain-Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535:SF1">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1771" evidence="1">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS85560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="105" mass="12137" checksum="1368AAD09D08D23C" modified="2019-04-10" version="1" fragment="single">MYEEDPSAVSYQDLRAEAQFYRGLARECQEQAARHDGQGMHGAALFYRQRAKKYKEEEHDANHRAADFLFDKGSERLDKENTLDLHFYHLDEAIAAVNTAVAMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZZ23</accession>
    <name>A0A3S0ZZ23_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_002651</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000051">
        <property type="protein sequence ID" value="RUS89633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZZ23"/>
    <dbReference type="OrthoDB" id="6147951at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018671521" evidence="3">
        <location>
            <begin position="26"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS89633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="279" mass="30918" checksum="6042015B59B3B17B" modified="2019-04-10" version="1">MRLDPRNFSAFTILTIFLLPTKCFSDTPVDEQQEKMPVVSEGHCTFDNSAQDCVRQTDNRQAYTEQLNQEPAGDSSKSEEDYQDFLHRSMERLEGMLEESRDQVLEKLRKVVDNMAHSRDHVIKKLDALLDTVSHSRLVTEIDHLLEEVSHSKIIEDMKSLPRELKESLLLSVRNRSYAAAGIMVIATMAVLLGGSLYFAWCHHDGWSLSYDYKALGASAVAAVTGAAQGQVEGQDAVDSDGRLAQRTAAQCSIGEEAGDKADGRRSDLGKDSVSVPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZZZ2</accession>
    <name>A0A3S0ZZZ2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dishevelled</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_001995</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DSH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000037">
        <property type="protein sequence ID" value="RUS90214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZZZ2"/>
    <dbReference type="STRING" id="188477.A0A3S0ZZZ2"/>
    <dbReference type="OrthoDB" id="10031689at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04438">
        <property type="entry name" value="DEP_dishevelled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06717">
        <property type="entry name" value="PDZ_Dishevelled-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.130:FF:000001">
        <property type="entry name" value="Segment polarity protein dishevelled homolog DVL-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000040">
        <property type="entry name" value="segment polarity protein dishevelled homolog DVL-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000014">
        <property type="entry name" value="Segment polarity protein dishevelled homolog DVL-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024580">
        <property type="entry name" value="Dishevelled_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008339">
        <property type="entry name" value="Dishevelled_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003351">
        <property type="entry name" value="Dishevelled_protein_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001158">
        <property type="entry name" value="DIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038207">
        <property type="entry name" value="DIX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015506">
        <property type="entry name" value="Dsh/Dvl-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10878">
        <property type="entry name" value="SEGMENT POLARITY PROTEIN DISHEVELLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10878:SF25">
        <property type="entry name" value="SEGMENT POLARITY PROTEIN DISHEVELLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02377">
        <property type="entry name" value="Dishevelled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00778">
        <property type="entry name" value="DIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12316">
        <property type="entry name" value="Dsh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01760">
        <property type="entry name" value="DISHEVELLED"/>
    </dbReference>
    <dbReference type="SMART" id="SM00021">
        <property type="entry name" value="DAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50841">
        <property type="entry name" value="DIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="DIX" evidence="10">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="8">
        <location>
            <begin position="242"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="DEP" evidence="9">
        <location>
            <begin position="419"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="193"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="518"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="663"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="716"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="193"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="666"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="726"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="761"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="791"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="848"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS90214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="887" mass="95603" checksum="79B80F4EC2FFE4DF" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A0Q5</accession>
    <name>A0A3S1A0Q5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_004471</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000102">
        <property type="protein sequence ID" value="RUS87725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A0Q5"/>
    <dbReference type="OrthoDB" id="6039838at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.22.10">
        <property type="entry name" value="Antistasin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050801">
        <property type="entry name" value="Ca-Dep_Lectins_ImmuneDev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801:SF63">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801">
        <property type="entry name" value="LITHOSTATHINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018757512" description="C-type lectin domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="39"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS87725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="274" mass="29909" checksum="D6B049FC3861A039" modified="2019-04-10" version="1">MRFLTLGLLVFFVLAVLGASSALGASCPQNFGTEDYGIYDNTCYFFISNKTLPYEQALEECQKNGGTLAMPKTEGLNYFLLDQMHKLNIEKAMWIGMHDKAGAGEREYIWEDGTEVKPWGNMHFLNGWMGEDCVALHPSDGKWHDYMCSDSRIFESDRLPFICQHTLKDDNLTDGNGAQADLDEGQGDSGNDTQGQGDSGNDTQGQGDSGNDTQGQGDSGNDTQGQGDSGNDTQGQGDKVEDDKDCPEFNCPNLDCGMDGFKTSDGCQICECNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A0T0</accession>
    <name>A0A3S1A0T0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_000725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000010">
        <property type="protein sequence ID" value="RUS91504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A0T0"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS91504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="231" mass="24865" checksum="BE5B5C58A7BCB89D" modified="2019-04-10" version="1">MEDNGTDMAAVDQVRGVPVILWKLPAHLGSMSPGSDANVSPVVLMAGGRGAASDQGWRRSVLPCLAVPSPAPTLSQRQSQGDAGVEVAWRSMDAMPGLYHSIRDTEVFTRKVTGGENHQCPCVAAGKSELSLSISRMRGDPQQFGYWTDVCLCVSVYVRLYVYLCGFTPAPIAVLFELFNPEDLHLLHCASDLRCLGLATPAMVDRSEAQRQPANAALQKTNNPSLCGHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A7C7</accession>
    <name>A0A3S1A7C7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_007726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000203">
        <property type="protein sequence ID" value="RUS84487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A7C7"/>
    <dbReference type="OrthoDB" id="10628585at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS84487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="117" mass="14476" checksum="C56CF7347B148BE6" modified="2019-04-10" version="1" fragment="single">VFFFFFFFFFFFFVFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFLETSAAAAGHQGSDELPCVHGPPQEHDLPVWPWGVPALRRQAQRVPHLPQVCGEAYPALLVCTQTHRIIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1ACG2</accession>
    <name>A0A3S1ACG2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_003936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000087">
        <property type="protein sequence ID" value="RUS88298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1ACG2"/>
    <dbReference type="OrthoDB" id="5859304at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46221:SF3">
        <property type="entry name" value="FERM AND PDZ DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46221">
        <property type="entry name" value="FERM AND PDZ DOMAIN-CONTAINING PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="1">
        <location>
            <begin position="19"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS88298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="127" mass="14433" checksum="586DC46CF54AB676" modified="2019-04-10" version="1" fragment="single">HKTQTSSWLPPRENWQDGTGLPYGWESAVDGHQKPYFINHLEKYTTRDDPRLDPDYVEPPQPRQVELVRDLDKGFGFVAGSEKPVIVRCVTEGECKGGACCLSLFYGWSETWTRASASWRAARNQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AFQ5</accession>
    <name>A0A3S1AFQ5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Transcription initiation factor TFIID 18 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_001504</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. TAF13, together with TAF11 and TBP, play key roles during promoter binding by the TFIID and TFIIA transcription factor complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the TFIID basal transcription factor complex, composed of TATA-box-binding protein TBP, and a number of TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Interacts with TBP, and more strongly with TAF10 and TAF11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000026">
        <property type="protein sequence ID" value="RUS90700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AFQ5"/>
    <dbReference type="STRING" id="188477.A0A3S1AFQ5"/>
    <dbReference type="OrthoDB" id="10266074at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07978">
        <property type="entry name" value="HFD_TAF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000028">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF5">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00082869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS90700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="159" mass="18380" checksum="271B03350D8D4F84" modified="2019-04-10" version="1" fragment="single">KGLNTSGIHSSLGEANPSLLFCRPILIHAKALMLLAVIYFEFVFKFEDDDNEEDAPLEKKKKIFSKELRCMMYGFGDDQNPYTESVDLVEDLVIDYITEMTKKAMEIGKSGRIIVEDLIFLIRKDPKKYSRVKELLLMNEELRKARKAFDEIKYATSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AGQ4</accession>
    <name>A0A3S1AGQ4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_000567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000008">
        <property type="protein sequence ID" value="RUS91594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AGQ4"/>
    <dbReference type="OrthoDB" id="5962695at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS91594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="289" mass="31888" checksum="9206244A5197F104" modified="2019-04-10" version="1" fragment="single">ESHFQRRRALIDDIKQKHLLDKSPRTNDSSPGFQYSSPVLKFHSPDHRRLSEKLKLSFGAVEENPECKSSSRTEEHDEKVTKVVEDQALGVDSETPQSVLTGTYATVPRRTSFEDDSFWAVTTLGLTEDKSLLEGSVAPQAEKDIFGLLHADFPGKDCRVIVKAEGLSLGTLYYHRGEQFQMSSSRPVANEDMAAAIRGIHSQVSQPKLSNCGPLGESPDSKTAQVNDQRMEPIVDDPQILAHNAQDSPGKGDRAAVKDETEEGVLDCLDGVKDIHNETFTLDLGKCIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AV79</accession>
    <name>A0A3S1AV79_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_023036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001782">
        <property type="protein sequence ID" value="RUS69200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AV79"/>
    <dbReference type="STRING" id="188477.A0A3S1AV79"/>
    <dbReference type="OrthoDB" id="1262810at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052957">
        <property type="entry name" value="Auxin_embryo_med"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32387:SF0">
        <property type="entry name" value="PROTEIN NO VEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32387">
        <property type="entry name" value="WU:FJ29H11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS69200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="706" mass="79508" checksum="3C6EDE8AA60C567F" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AVM6</accession>
    <name>A0A3S1AVM6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_018786</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000935">
        <property type="protein sequence ID" value="RUS73449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AVM6"/>
    <dbReference type="STRING" id="188477.A0A3S1AVM6"/>
    <dbReference type="OrthoDB" id="267079at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034085">
        <property type="term" value="P:establishment of sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002532">
        <property type="entry name" value="DEAD/H-box helicase 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF41">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE DDX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS73449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="615" mass="68877" checksum="AAD5B0D90AB86649" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AW83</accession>
    <name>A0A3S1AW83_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphatidylserine decarboxylase</fullName>
            <ecNumber evidence="3">4.1.1.65</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_022293</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. May be involved in lipid droplet biogenesis at the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Phospholipid metabolism; phosphatidylethanolamine biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="3"/>
    <dbReference type="EMBL" id="RQTK01001529">
        <property type="protein sequence ID" value="RUS69951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AW83"/>
    <dbReference type="STRING" id="188477.A0A3S1AW83"/>
    <dbReference type="OrthoDB" id="4330at2759"/>
    <dbReference type="UniPathway" id="UPA00558"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF6">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS69951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="248" mass="28220" checksum="CACC4DAE8DA3CCF1" modified="2019-04-10" version="1" fragment="single">TIKNYLINLAIKTFEINISEAESDDINSYPTFNAFFTRKLKDGVRPLEANSSILSSPADGVLSEFGKIEDKTLIQAKKRDYSLEKLIVKSSDTNFTDFATIYLSPKDYHRVHMPIDGKLTKMVYIPGKLFSVNKTTTNNIDEIFTKNERLVCYFDTAIGEVAVIFVGALLVAGIETVWHGKVAPSYYKEPKEWNYTDGYNLEYKKGDTLGWFNFGSTVVMLFPDNKIDMLFEKKNSEIQVNQSLAKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AXT9</accession>
    <name>A0A3S1AXT9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Translation factor GUF1 homolog, mitochondrial</fullName>
            <ecNumber evidence="8">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Elongation factor 4 homolog</fullName>
            <shortName evidence="8">EF-4</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">GTPase GUF1 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Ribosomal back-translocase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_022183</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the GTP-binding elongation factor family. LepA subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="8"/>
    <dbReference type="EMBL" id="RQTK01001501">
        <property type="protein sequence ID" value="RUS70058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AXT9"/>
    <dbReference type="STRING" id="188477.A0A3S1AXT9"/>
    <dbReference type="OrthoDB" id="1074at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097177">
        <property type="term" value="F:mitochondrial ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03699">
        <property type="entry name" value="EF4_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16260">
        <property type="entry name" value="EF4_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01890">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000078">
        <property type="entry name" value="Elongation factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000015">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000007">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2570:FF:000001">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000004">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="entry name" value="Elongation factor 4, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512:SF7">
        <property type="entry name" value="TRANSLATION FACTOR GUF1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="TRANSLATION FACTOR GUF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="54"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="63"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="127"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="181"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS70058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="646" mass="73616" checksum="F16097EA586B750B" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AZ39</accession>
    <name>A0A3S1AZ39_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipid scramblase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_021329</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phospholipid scramblase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001308">
        <property type="protein sequence ID" value="RUS70901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AZ39"/>
    <dbReference type="STRING" id="188477.A0A3S1AZ39"/>
    <dbReference type="OrthoDB" id="444338at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017128">
        <property type="term" value="F:phospholipid scramblase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005552">
        <property type="entry name" value="Scramblase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248:SF9">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03803">
        <property type="entry name" value="Scramblase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS70901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="196" mass="21993" checksum="38EC9218F7EAA5F6" modified="2019-04-10" version="1" fragment="single">MTASSDSTSSSSDSKESQADSEVTKVYRKSQASSIVSAVPYGLEPLVNMQEIVVKQNLELLETCLGCETSNSYDIQNRLGEKFYSATESSWFCFRNCCNVCCGSSRPLTIEIKDLLGEMVLKIRRPWRCQRFWCFCFQQKVSVELPDGTLLGKVSQTCSCCRPWFKVTNATGEAIFKIRGPVCQCNICCKDVEYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AZL6</accession>
    <name>A0A3S1AZL6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fibrinogen C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_019851</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001073">
        <property type="protein sequence ID" value="RUS72391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AZL6"/>
    <dbReference type="STRING" id="188477.A0A3S1AZL6"/>
    <dbReference type="OrthoDB" id="7972392at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF254">
        <property type="entry name" value="TENASCIN-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018586849" description="Fibrinogen C-terminal domain-containing protein" evidence="4">
        <location>
            <begin position="28"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="5">
        <location>
            <begin position="295"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS72391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="504" mass="56339" checksum="92DE78253506BE1A" modified="2019-04-10" version="1">MGLLALFTTARLFTLLALVSLHRPAAGLELSLVPNSRILTDPNSPCGTLVCKDSGSGYRRDGSHITNMTLFVVETTRSGGGGGDGGGDGDGGGGSSGNEPEKLSRLASVSVQQPSLNQAYAGMKLYGDLKDGQATLRVELPKQADCLVEYVCELREVDAGRKQTVTSYRLVQQPCQSVTTEHDSRIISLILQRLSPSIKRLDVKLDRIEDRYQELKNDFTNLFANVNKDMEELYTRIIVVTDSMEENFIVLKDDVMKSWQQLQLHANEATSKALNDFRNVATKLNSSISSDIKSDLTGFFMSDCRKNTPVLVHPNLTPHPVIYRSAFLDVDFPFLCDTITDGGGWIVIQRRSTGKEDFYRTWADYKAGFGTLDDDFWLGNDNIHSITSTGRYELRVDLKYNGQSVFAHYDEFSIANEDKNYALKIGSYDGTAGDSLTYHNGFDFSTHDNKNDPNGDSCARMFIGAWWYYECFLSNLNGKWGKTAIWHERVVITFSEMKIRKLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B0N6</accession>
    <name>A0A3S1B0N6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_018970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000956">
        <property type="protein sequence ID" value="RUS73275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B0N6"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS73275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="113" mass="12738" checksum="AAA20371981C4206" modified="2019-04-10" version="1" fragment="single">SGQHHCYQSHTSLELIQDYHRIYLALFEVFKLQRKKKKKEEIYITDLRQQHIAVSNTISILIDQRQVPDIPDHITSTTTVSAAAAVAAETTTTVSASASPLVSRPTSKSWHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B1X6</accession>
    <name>A0A3S1B1X6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_022321</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Integrator subunit 7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001536">
        <property type="protein sequence ID" value="RUS69914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B1X6"/>
    <dbReference type="STRING" id="188477.A0A3S1B1X6"/>
    <dbReference type="OrthoDB" id="1921953at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033060">
        <property type="entry name" value="INTS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056517">
        <property type="entry name" value="INTS7_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056516">
        <property type="entry name" value="INTS7_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13322">
        <property type="entry name" value="C1ORF73 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13322:SF2">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24437">
        <property type="entry name" value="INTS7_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24436">
        <property type="entry name" value="INTS7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrator complex subunit 7 N-terminal" evidence="6">
        <location>
            <begin position="24"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Integrator complex subunit 7 helical bundle" evidence="7">
        <location>
            <begin position="527"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS69914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="656" mass="72104" checksum="78934D87A66B44BD" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B3B5</accession>
    <name>A0A3S1B3B5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_021283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001297">
        <property type="protein sequence ID" value="RUS70954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B3B5"/>
    <dbReference type="OrthoDB" id="10042433at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053121">
        <property type="entry name" value="Spore_Coat_Assembly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35365">
        <property type="entry name" value="LP04239P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35365:SF18">
        <property type="entry name" value="MUCIN-19-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS70954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="158" mass="17701" checksum="87C611BA144A9524" modified="2019-04-10" version="1">MNISKRFTCSTQPNSTQLNPTQLNSPQLNSTQPNSTQLNSTQLNPTQLTLIQLNPTELNLTQLNVTQLNSTQLISTQLNPTQFTLIQLNPTELNSTQINSAQLISTQLKPNSTHTNSTHPNSTQLNSTQPNPTQTYQFELSVARNQLVNPVRTCWLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B546</accession>
    <name>A0A3S1B546_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_017023</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000762">
        <property type="protein sequence ID" value="RUS75207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B546"/>
    <dbReference type="STRING" id="188477.A0A3S1B546"/>
    <dbReference type="OrthoDB" id="907479at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1770:FF:000001">
        <property type="entry name" value="Cytochrome b reductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043205">
        <property type="entry name" value="CYB561/CYBRD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10106">
        <property type="entry name" value="CYTOCHROME B561-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10106:SF0">
        <property type="entry name" value="LD36721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="12">
        <location>
            <begin position="25"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS75207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="251" mass="28130" checksum="B8A0109F01A5FFB9" modified="2019-04-10" version="1">MHSLYLDSNMASSADMRYFNWVVLLVQLLGVVSVVITAVWMGHFSQGGFAWTEDPAKEFSYHPLFMVIGLIFLYGDGILAYRVFRNDRKFYIKILHGGMHVAALIFASVGLKAVFDSHNLADPPLANLYSLHSWLGLLVVIGFGLQWVLGFACFLLPWLGMSIRTMYMPYHTFWGVTLLILATATALMGITEKAIFSMAKNGYTSHSREGTLINCLGLILVIFTGLVVYLVTKPEYKRQPAPDEEHVPLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B5D2</accession>
    <name>A0A3S1B5D2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_011961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000401">
        <property type="protein sequence ID" value="RUS80277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B5D2"/>
    <dbReference type="OrthoDB" id="6162835at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS80277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="317" mass="34817" checksum="3424BD323532ECD3" modified="2019-04-10" version="1">MAKDRLNKPPEFYKYYDIATKATYRENTLDGAKRAAGVGKSSVSTKRKMDGMTPRFSPPPSVSGKERAHRDKAAVCEESRSSAHTASSKSSSSSHRYVAPLTSLTHSHFPRKTKTKSTLTPSSSVSQAKLPPKHTHSKTSSHEPKSILKNSPRRRLSTTSDDDVLFRASKQTQTTMQYPPSCPLRLSPTSSSALTWPAEIAGAAPTNSTQPSESDLSDVMPCLRGEDISHDLYSRLRICYARSISERPVKPADPHTAAAASQCQDKSRQDTDKDILSRCSYRLAARPRRASEPSVSKRVTFHDQAPRLEAGVPPPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B741</accession>
    <name>A0A3S1B741_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_014645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000569">
        <property type="protein sequence ID" value="RUS77587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B741"/>
    <dbReference type="OrthoDB" id="6161934at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS77587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="141" mass="15355" checksum="ECE4E5F8669C2E2E" modified="2019-04-10" version="1" fragment="single">MASIWSLASICLVYYGLLGVCFIKGQTLKPAIAKDGGNAVVSFDIPDTDQVNGAKVLFVKLDPQNGTPLELFYNILFVELATFKLAFPERLESKIASEISGRTLTINIRGVNASDAGYIRCYTLPKVENLIPNCGQQLIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B7L9</accession>
    <name>A0A3S1B7L9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_015227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000618">
        <property type="protein sequence ID" value="RUS77002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B7L9"/>
    <dbReference type="STRING" id="188477.A0A3S1B7L9"/>
    <dbReference type="OrthoDB" id="44015at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS77002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="285" mass="28990" checksum="9A5464E6989DE561" modified="2019-04-10" version="1">MTRGGKAPASPSLSGTHSSPHSGPGLEDAVKALGLAMSPAKGGPAGRTNVSKPQSRPLSPGQPIMGRSSPAYNLGEDVSSTVPGSYGVEGVGHDMGQSGQAGMSNQQEDLSGKGFDAFGDVLQPMNKTAGAEAPLPSRQAKPLGSDLDTSLASLASNLNMGAPGAPMMYQQPMGAPMGQPMMGMGQPPMGMMGMPMQPGMGMRGMMGGMPGGPPAMYNAQQPAMMGGFQPQRPPAPSNSGTGAVNDPFGALDEQKNRSGNTKDLNLGPLAPQSRVLETELSLRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B8I4</accession>
    <name>A0A3S1B8I4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Elongin-B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Elongin 18 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">RNA polymerase II transcription factor SIII subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">SIII p18</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Transcription elongation factor B polypeptide 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">EGW08_017600</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">EC2010</strain>
            <tissue evidence="19">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Heterotrimer of an A (ELOA, ELOA2 or ELOA3P), ELOB and ELOC subunit. The elongin BC complex interacts with EPOP; leading to recruit the elongin BC complex to Polycomb group (PcG) target genes, thereby restricting excessive activity of the PRC2/EED-EZH2 complex. Component of multiple cullin-RING E3 ubiquitin-protein ligase complexes composed of Elongin BC (ELOB and ELOC), a cullin (either CUL2 or CUL5), a catalytic subunit (either RBX1 or RNF7/RBX2), as well as a substrate adapter protein that can be either ASB2, ASB9, ASB11, KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B, FEM1C, LRR1, PCMTD1, SOCS1, SOCS2, SOCS5, SPSB1, SPSB3, ELOA, VHL, WSB1 or RAB40C. As part of the Elongin BC E3 ubiquitin ligase complex; interacts with NRBP1. May also interact with DCUN1D1, DCUN1D2, DCUN1D3 and DCUN1D5. May form oligomers as a KLHDC2/KLHDC3-ELOB-ELOC complex; this interaction is autoinhibitory for the E3 ligase complex as the substrate-binding site of KLHDC2/KLHDC3 is blocked in the oligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the Elongin B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000812">
        <property type="protein sequence ID" value="RUS74646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B8I4"/>
    <dbReference type="STRING" id="188477.A0A3S1B8I4"/>
    <dbReference type="OrthoDB" id="7537057at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070449">
        <property type="term" value="C:elongin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030891">
        <property type="term" value="C:VCB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01788">
        <property type="entry name" value="Ubl_ElonginB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000108">
        <property type="entry name" value="Elongin-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039049">
        <property type="entry name" value="ELOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13248:SF4">
        <property type="entry name" value="ELONGIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13248">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="18">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="90"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00076690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00083653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00093515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RUS74646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="121" mass="13545" checksum="9E94F1D39ECAC91A" modified="2019-04-10" version="1">MDVFLMVRRKKTTIFTDAKESTTMGELKKMIEGILKVPPETQRLFKDETPMTDDHKALSDYGYTSTVAKAQSPATIGLVFKTEEGEWEPLDIQPLSNPPELPDVMKPQDASQAHQPEPNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BAX5</accession>
    <name>A0A3S1BAX5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_015919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000672">
        <property type="protein sequence ID" value="RUS76312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BAX5"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018613456" evidence="1">
        <location>
            <begin position="20"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS76312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="226" mass="24749" checksum="6A563790160A3172" modified="2019-04-10" version="1">MVTLSLFKVLFVSNGIAFGDELVSTAGCVVALRQKETCMMDYAVNTQADWDRDKTIILTISLFYLLLAHGKFADTCILIRMGPVQADQRTRARGTEAAASARSSDALAPTVPLDGLSHRGSSFLVLRAWADSGSAIEGEVPPTTHDKKKHQKKMKTKAPLPAVASNVMAEFIFCCSPNPFLLALPPYVLQPQLARQAHTRRLHCEILCCYVPAKYVRQDGKGEALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BBA6</accession>
    <name>A0A3S1BBA6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TAF6 C-terminal HEAT repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_007971</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000211">
        <property type="protein sequence ID" value="RUS84278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BBA6"/>
    <dbReference type="STRING" id="188477.A0A3S1BBA6"/>
    <dbReference type="OrthoDB" id="6621890at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08050">
        <property type="entry name" value="TAF6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.770">
        <property type="entry name" value="TAF6, C-terminal HEAT repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037796">
        <property type="entry name" value="TAF6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011442">
        <property type="entry name" value="TAF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046344">
        <property type="entry name" value="TAF6_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221:SF22">
        <property type="entry name" value="TAF6-LIKE RNA POLYMERASE II P300_CBP-ASSOCIATED FACTOR-ASSOCIATED FACTOR 65 KDA SUBUNIT 6L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07571">
        <property type="entry name" value="TAF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAF6 C-terminal HEAT repeat" evidence="7">
        <location>
            <begin position="92"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="427"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="539"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="618"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="682"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="543"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="704"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="755"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="832"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS84278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="850" mass="96255" checksum="CC9B88ADC3B96EAE" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BBL5</accession>
    <name>A0A3S1BBL5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Small monomeric GTPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_007772</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the small GTPase superfamily. Di-Ras family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000204">
        <property type="protein sequence ID" value="RUS84476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BBL5"/>
    <dbReference type="STRING" id="188477.A0A3S1BBL5"/>
    <dbReference type="OrthoDB" id="265044at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000303">
        <property type="entry name" value="GTP-binding protein Di-Ras2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="186"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS84476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="22555" checksum="D536C4CFB33787AC" modified="2019-04-10" version="1">MPEQSNDYRVVVFGAGGVGKSSLVLRFVKGTFRENYIPTIEDTYRQVISCNKQVCTLQITDTTGSHQFPAMQRLSISKGHAFILVYSISSRQSLEELKPIHAEIVEMKGGDLEGGSIPVMLVGNKCDDVNRECTVQEGAELAKRWNCAFLETSAKTNHNVKELFQELLQLETRRAVSLQLETNKSKAQRRRDKLKGKCSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BCA7</accession>
    <name>A0A3S1BCA7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cullin family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_007405</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000191">
        <property type="protein sequence ID" value="RUS84864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BCA7"/>
    <dbReference type="STRING" id="188477.A0A3S1BCA7"/>
    <dbReference type="OrthoDB" id="5581181at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044554">
        <property type="entry name" value="ANAPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057975">
        <property type="entry name" value="TPR_ANAPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957:SF1">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25773">
        <property type="entry name" value="TPR_ANAPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cullin family profile" evidence="3">
        <location>
            <begin position="737"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="262"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="696"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1015"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS84864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1015" mass="113874" checksum="527E8D30D2F7D0D5" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BEM1</accession>
    <name>A0A3S1BEM1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_013209</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RIN (Ras interaction/interference) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000476">
        <property type="protein sequence ID" value="RUS79026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S1BEM1"/>
    <dbReference type="OrthoDB" id="21085at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01776">
        <property type="entry name" value="RA_Rin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00173">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF104">
        <property type="entry name" value="PROTEIN SPRINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23268">
        <property type="entry name" value="RIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="5">
        <location>
            <begin position="6"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="VPS9" evidence="7">
        <location>
            <begin position="1516"/>
            <end position="1664"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="6">
        <location>
            <begin position="1680"/>
            <end position="1769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="249"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="489"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="607"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="739"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="840"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="889"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1093"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1166"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1297"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="261"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="493"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="533"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="619"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="757"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="844"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="889"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1123"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1169"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1195"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1212"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1222"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1235"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1297"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS79026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1788" mass="197198" checksum="82D18EFE4F6C86F8" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BF21</accession>
    <name>A0A3S1BF21_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">BEACH-type PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_012952</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000460">
        <property type="protein sequence ID" value="RUS79297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000001">
        <property type="entry name" value="neurobeachin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
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        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046851">
        <property type="entry name" value="NBCH_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010508">
        <property type="entry name" value="NBEA-like_DUF1088"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031570">
        <property type="entry name" value="NBEA/BDCP_DUF4704"/>
    </dbReference>
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        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF162">
        <property type="entry name" value="NEUROBEACHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06469">
        <property type="entry name" value="DUF1088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15787">
        <property type="entry name" value="DUF4704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20426">
        <property type="entry name" value="NBCH_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="8">
        <location>
            <begin position="1692"/>
            <end position="1800"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="7">
        <location>
            <begin position="1819"/>
            <end position="2108"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="2403"/>
            <end position="2444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="574"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="956"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1113"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="574"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="588"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="603"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="623"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="639"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="649"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="675"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="697"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="713"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="734"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="767"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1128"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1145"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1161"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1180"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1209"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1246"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1261"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1284"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1296"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1314"/>
            <end position="1323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS79297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2492" mass="277829" checksum="12A358B9923DF215" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BH23</accession>
    <name>A0A3S1BH23_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_011663</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000384">
        <property type="protein sequence ID" value="RUS80569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="188477.A0A3S1BH23"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS80569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="155" mass="22102" checksum="ED578C506D7426CC" modified="2019-04-10" version="1" fragment="single">FRNHYRLKWFRDHDSLKWFMHYYRTKLFVDHYRRKWFMDHYKRKWFRDFCRRKWFRDHYRRKWFRNHYRLKCFRNHYRRNWFRNHYRRKWFIHHYRRKWFMDHCIRKWFRDFCRRKSFRDHYRRKWFRNHYRLKWFRDHYRRKWFRDLCRRKWFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BII5</accession>
    <name>A0A3S1BII5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Helicase SKI2W</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_003114</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000065">
        <property type="protein sequence ID" value="RUS89106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S1BII5"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070478">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000354">
        <property type="entry name" value="ATP-dependent RNA helicase SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000447">
        <property type="entry name" value="helicase SKI2W isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000001">
        <property type="entry name" value="Ski2 ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040801">
        <property type="entry name" value="Ski2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17911">
        <property type="entry name" value="Ski2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="342"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="607"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="245"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="912"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS89106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1290" mass="144986" checksum="62413B6724B1115A" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BJK3</accession>
    <name>A0A3S1BJK3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mortality factor 4-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_009884</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000289">
        <property type="protein sequence ID" value="RUS82369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BJK3"/>
    <dbReference type="STRING" id="188477.A0A3S1BJK3"/>
    <dbReference type="OrthoDB" id="124855at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.30:FF:000001">
        <property type="entry name" value="Mortality factor 4-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000024">
        <property type="entry name" value="Mortality factor 4-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.30">
        <property type="entry name" value="MRG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008676">
        <property type="entry name" value="MRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038217">
        <property type="entry name" value="MRG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026541">
        <property type="entry name" value="MRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053820">
        <property type="entry name" value="MSL3_chromo-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880:SF48">
        <property type="entry name" value="MORTALITY FACTOR 4 LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05712">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22732">
        <property type="entry name" value="MSL3_chromo-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51640">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="12">
        <location>
            <begin position="6"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="93"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="93"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="148"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS82369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="389" mass="45210" checksum="5241F807F6B6D502" modified="2019-04-10" version="1">MAPKPKFQEAEKLLCYHGPLLYEAKCMKLDIRDGKVHYLIHYNGWNKNWDEWVQESRIVKNNEAGYQKQRELLKNHGALTKKTKTAKKLEKELLKQQKNTEKAAKEKELKDAKKEKASTPKEKQTAKEKEKKEKETKQRPGTPQPSAADRKREREIEKEKAQNEKDKEQKDKKDDKDKSFSAQSSQSSSSSTQDSATGEPKRKRAKTDQSVESEETYLSKIEVKIKIPEDLKPVLVDDWDLITRQKMLVKVPCKMTVDEIIDEYIKSKCAKNSNVNKDAIVETMLGCKDYFNVMLGPQLLYKFERPQYSEILSEHPDKPMSSIYGAIHFLRLFVRLGAMLAYTALDERTIHIILTHIHDFLKYLSKNGPMFFKIANYEIAPPDYHRKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BJU2</accession>
    <name>A0A3S1BJU2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_023315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001922">
        <property type="protein sequence ID" value="RUS68922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BJU2"/>
    <dbReference type="STRING" id="188477.A0A3S1BJU2"/>
    <dbReference type="OrthoDB" id="6149870at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS68922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="166" mass="18404" checksum="074CB72DA4789258" modified="2019-04-10" version="1" fragment="single">IINGKDANISDWPWAVALQYVGTHVCGGGIIHPYFILTAAHCMRFVWLSLAILSSSSCPQVRRVIEYPNYSQFDGKDLALVELMTPLIYSQNVRPLCLPEPDDVFTRRSLCMLAGWGFTSGSDVLQQAKFSLVDTDLCNGTDMWNGAMAENERCAGYFNSFFAACS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BNC2</accession>
    <name>A0A3S1BNC2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_000035</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000001">
        <property type="protein sequence ID" value="RUS92182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BNC2"/>
    <dbReference type="STRING" id="188477.A0A3S1BNC2"/>
    <dbReference type="OrthoDB" id="6110130at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="341"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="405"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="431"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="232"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="447"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS92182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="568" mass="64836" checksum="0B320205F5FB8855" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BNZ7</accession>
    <name>A0A3S1BNZ7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_004125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000093">
        <property type="protein sequence ID" value="RUS88072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BNZ7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS88072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="266" mass="28569" checksum="E0096C702A760207" modified="2019-04-10" version="1">MIFYKTNTAQVVKRDNPKPALTLSGPVCLWSRHSGRQVDRAHVLRPQLFSDEPGDETRVKLSSRLLSAAGDLVWAWGRHVAGVPPGSWLEQGPPRRATHLVRAGPPSPRDSSDWPPCCWVPPGSSCQVVLTSAECGGRPGVGLGPPCCWGSPGILVRAGPPSPRDSSDCWESWRRAMPNSSHRRNRCLPPWQGLVSQFSPLLLTSVAIACPLCGPVLITCRIADVAALCCRYGAVTTDGVADAAAVAGAGQRRLCCVWRRGGDDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BR35</accession>
    <name>A0A3S1BR35_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_019374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001007">
        <property type="protein sequence ID" value="RUS72868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BR35"/>
    <dbReference type="OrthoDB" id="10657325at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="466"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS72868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="503" mass="54444" checksum="28A1ACC40BA6D964" modified="2019-04-10" version="1" fragment="single">MTDRPPGARTSSPEVRGRQSRVPLTPAPAPGVSSALRDLVSILTTKITRSTKRPNKATTRHTHFSLFALISMKCPASASSAVNNTSLCSGRKDFSKDLERSVSLSIDSLLDKMSLSSSKEPACHMQTRTQDTEVKNDRNNNMATNASSRNCVYNSDSSVGMATDVDNGVNKHRTRKMKANHDGKERNDAETYVMLRRRLHRLDNELSSSGSDEDASDRNNRCCHDNMHGRFRSQRQERRLSHRMSFSRSQSLSSLDSAFVDGVDRPGSGTYSPSASTSVSSLSSTWSLGSSGNNLSLANSLDSHAWTSVVTPTGHSLVPDNQPEHHDSVSVLSSSPPTKQSASNVYSCEAVLSQTERSDGLCSVNPDVTPSLTQESGHEREDSFVCSSSVSANSVTENRSDDSDVTPVEPTSTPVQQVVVRSARQTRRRHRSRDHNNNAGTQHGAAITEFLPNAPCRLGDCFSKKGVLSLVALVVYTVALMAVFGLLGAVGKALQAGKDTHTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BRC5</accession>
    <name>A0A3S1BRC5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reactive oxygen species modulator 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Protein MGR2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_019190</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000982">
        <property type="protein sequence ID" value="RUS73052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BRC5"/>
    <dbReference type="STRING" id="188477.A0A3S1BRC5"/>
    <dbReference type="OrthoDB" id="5409308at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018450">
        <property type="entry name" value="Romo1/Mgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525:SF1">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10247">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01378">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS73052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="80" mass="8327" checksum="F2E800A8319BDE51" modified="2019-04-10" version="1">MPVPSSAYGHQGAPSCFDRIKVGFMMGFCVGMASGALFGGFSALRYGLRGRELFSTVGKTMIQGGGTFGTFMSIGTGIRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BTC0</accession>
    <name>A0A3S1BTC0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_017866</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000836">
        <property type="protein sequence ID" value="RUS74385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BTC0"/>
    <dbReference type="STRING" id="188477.A0A3S1BTC0"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF372">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="288"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="58"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS74385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="337" mass="37850" checksum="F8A7D8BC3FA11FAA" modified="2019-04-10" version="1">MSNDSDFTALSLSNAANQATSAPGYFVKPLVSVAVMDMFSVVNGFGLCSLLSFLGVFTNIANIIVYARMGLSETSNINFLALSVLDFFVSLVTFFLKFLYSPVLRSLSTGPITTHISMSLSPAMMSTVGASAMMTALISTERCLCVVFPLKVKTFLTPRRVLYLLLTIVAYMVTFLLVFYIDVGAPFINQIGKQGFYFFCFFAVPSTTCFFIVLLSTLFLVIRLRKNLKWRQERSSQSAKSSCKENKLVRTIIAISTIFIICFFPNVLNFFVQIIHPSFRYLDPYLGTLAVVMFSFSGVTQAISSSINIFFYYRMSSKFKRVFSETFLCYKKNLNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BVJ2</accession>
    <name>A0A3S1BVJ2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_002446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000048">
        <property type="protein sequence ID" value="RUS89743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BVJ2"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS89743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="127" mass="14171" checksum="5828FE298E948EF2" modified="2019-04-10" version="1">MVPCRPDCGCALCRGQGSSRATRSRLCCPGHWPRSSAEDRPRCPNDQAQRKVIPRVKVIGVQTRMRRLKQRSGKHSTGTPWPTTSPIRAALSCRIFPKWRRISLAPRIPTSMRSAGGRPITAQSLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C0R8</accession>
    <name>A0A3S1C0R8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EGW08_012414</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">EC2010</strain>
            <tissue evidence="15">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000426">
        <property type="protein sequence ID" value="RUS79815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C0R8"/>
    <dbReference type="STRING" id="188477.A0A3S1C0R8"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02904">
        <property type="entry name" value="Macro_H2A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000013">
        <property type="entry name" value="Core histone macro-H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.220.10:FF:000002">
        <property type="entry name" value="Core histone macro-H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035796">
        <property type="entry name" value="Macro_H2A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Macro" evidence="14">
        <location>
            <begin position="192"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RUS79815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="375" mass="39738" checksum="81DD4106D95C04BA" modified="2019-04-10" version="1">MSARGGKKKQKIMSKSARAGVLFPVARMLRYLRKDTHHLRIGAGSPVYMAAVIEYLVAEILELAGNAAKEFKKGRITPRHILLAIANDEELHQLLKHVTIAQGGVVPKIHAALVGPSRGKKGAAATTASTSSSTSRPSVASPSKLKAATNVAAKKLKGALAANNVAPLIKAASFKGKPKKADSIPDGSGGFLTLSEKKLFLGQKLTVMQGDLVKATADAIVHPTNSSFYFGGEVGQAIQRAGGKEFQQEVDLLKAQGSIGNAEAAICPGHKFAAKFVIHVNSPTWSETNAQQNLDKAVKNVLKVADDKSLKSVALPSISSGNAGFPKQTAAQIILASIRDYFKTAKSSSLKQIFFVLYDAESVNVYTTELARLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C273</accession>
    <name>A0A3S1C273_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_011355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000368">
        <property type="protein sequence ID" value="RUS80884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C273"/>
    <dbReference type="STRING" id="188477.A0A3S1C273"/>
    <dbReference type="OrthoDB" id="10038545at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS80884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="20691" checksum="6009279BCCF2016A" modified="2019-04-10" version="1">METVKGVEVVRTYPDKDICDLLCVTHDRALARRIEVASNFCWDGPRERVDLSSLDFLLPSGKGASPALIVSHPHGKPKKITVGELTDRNFTHVGYNAATCPGSSGAPVLFGIISNLWLYPDWFVPIHSGGFCTYSTNLLARFMDKLRGRKPKLDQHNYGNRFLMDDYIEKFRFINTTYSSCWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C6R7</accession>
    <name>A0A3S1C6R7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_007728</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000203">
        <property type="protein sequence ID" value="RUS84489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C6R7"/>
    <dbReference type="STRING" id="188477.A0A3S1C6R7"/>
    <dbReference type="OrthoDB" id="5877963at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015501">
        <property type="term" value="F:glutamate:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015175">
        <property type="term" value="F:neutral L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="entry name" value="Sodium:dicarboxylate symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050746">
        <property type="entry name" value="DAACS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018107">
        <property type="entry name" value="Na-dicarboxylate_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958:SF63">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958">
        <property type="entry name" value="SODIUM/DICARBOXYLATE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00173">
        <property type="entry name" value="EDTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="Proton glutamate symport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00714">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018704734" description="Amino acid transporter" evidence="10">
        <location>
            <begin position="24"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS84489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="409" mass="44194" checksum="FA46CF847F685325" modified="2019-04-10" version="1">MTTTLSAVIIGIVMVLSIHPGSADDKAKLRQEGKSTDAKPLDSLLDLISQCFPENLITACFERSTTEITQVKSDPRTNETDNTTYTEMLDKYGLKRDRGTNVLGIVVFSIALGVVINHLGEEGEPLKKFFQALNSATMVLINVVIWFTPIGIMFLIAGKFISTDDIGDVLSDLGKYMATVLGGLFIHGFILLPLIYFVTTRKNPGRFALNMAKALFTAWGTASSSATLPLTMDCLVNKNKVNLNIVRFVAPVGATINMDGTALYEAVACIFIAQINGMSLSIADVIIVSLTATAAAIGAAGVPQAGLVTLVIVLTAVGLPTEDVTFILSIDWFLDRFRTAINVWGDSVGAGILNHLFRHTFKDEVDGDNAVELDMEPNNDQTLNGDEPPSYNGINNEAFDKDEVHLTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1CAR9</accession>
    <name>A0A3S1CAR9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="10">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_004572</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the UPL family. K-HECT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="10"/>
    <dbReference type="EMBL" id="RQTK01000104">
        <property type="protein sequence ID" value="RUS87649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S1CAR9"/>
    <dbReference type="OrthoDB" id="412600at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000051">
        <property type="entry name" value="E3 ubiquitin-protein ligase HECTD1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000085">
        <property type="entry name" value="E3 ubiquitin-protein ligase HECTD1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000014">
        <property type="entry name" value="E3 ubiquitin-protein ligase HECTD1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000033">
        <property type="entry name" value="E3 ubiquitin-protein ligase HECTD1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000007">
        <property type="entry name" value="Putative E3 ubiquitin-protein ligase HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010606">
        <property type="entry name" value="Mib_Herc2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037252">
        <property type="entry name" value="Mib_Herc2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06701">
        <property type="entry name" value="MIB_HERC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159034">
        <property type="entry name" value="Mib/herc2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51416">
        <property type="entry name" value="MIB_HERC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="390"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="421"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="MIB/HERC2" evidence="13">
        <location>
            <begin position="1302"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="12">
        <location>
            <begin position="2134"/>
            <end position="2586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="494"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="658"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1369"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1620"/>
            <end position="1673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1779"/>
            <end position="1822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="494"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="663"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1374"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1385"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1411"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1432"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1620"/>
            <end position="1652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1653"/>
            <end position="1673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1781"/>
            <end position="1818"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="9">
        <location>
            <position position="2555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS87649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="2586" mass="285670" checksum="24DABCAB99DC9425" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1CBU2</accession>
    <name>A0A3S1CBU2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Anoctamin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_003862</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the anoctamin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000084">
        <property type="protein sequence ID" value="RUS88406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1CBU2"/>
    <dbReference type="OrthoDB" id="296386at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032394">
        <property type="entry name" value="Anoct_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF84">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16178">
        <property type="entry name" value="Anoct_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="507"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="547"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="593"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="716"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="766"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="875"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin dimerisation" evidence="11">
        <location>
            <begin position="110"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="10">
        <location>
            <begin position="339"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="928"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU280814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS88406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="948" mass="108655" checksum="7BE352558057C209" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1CCD0</accession>
    <name>A0A3S1CCD0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Syndecan/Neurexin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_003370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000072">
        <property type="protein sequence ID" value="RUS88825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1CCD0"/>
    <dbReference type="STRING" id="188477.A0A3S1CCD0"/>
    <dbReference type="OrthoDB" id="10650981at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018551204" description="Syndecan/Neurexin domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="800"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="451"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="677"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="724"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="929"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1011"/>
            <end position="1030"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS88825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1044" mass="108078" checksum="B4DD8E8C93531F2C" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1CEF1</accession>
    <name>A0A3S1CEF1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_001779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000032">
        <property type="protein sequence ID" value="RUS90438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1CEF1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS90438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="103" mass="11847" checksum="51876D1192D5A965" modified="2019-04-10" version="1" fragment="single">VSAVNVWGHTLPKPISRAHSCLPKTQGSIFAATGVQFPIRRETHTVHWSKKPLCIHTHLFSSIIIKLVHLEVFSTTHKKVLRRMKRSCVHRCWCLYLLDLLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1CF80</accession>
    <name>A0A3S1CF80_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_001192</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000019">
        <property type="protein sequence ID" value="RUS91064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1CF80"/>
    <dbReference type="STRING" id="188477.A0A3S1CF80"/>
    <dbReference type="OrthoDB" id="6151170at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="178"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="454"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="667"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="701"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS91064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="810" mass="90255" checksum="4B866887804E539C" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1GZA0</accession>
    <name>A0A3S1GZA0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apoptotic chromatin condensation inducer in the nucleus</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_023113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001821">
        <property type="protein sequence ID" value="RUS69124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1GZA0"/>
    <dbReference type="STRING" id="188477.A0A3S1GZA0"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061574">
        <property type="term" value="C:ASAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052793">
        <property type="entry name" value="EJC-associated_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032552">
        <property type="entry name" value="RSB_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46589">
        <property type="entry name" value="APOPTOTIC CHROMATIN CONDENSATION INDUCER IN THE NUCLEUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46589:SF1">
        <property type="entry name" value="APOPTOTIC CHROMATIN CONDENSATION INDUCER IN THE NUCLEUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16294">
        <property type="entry name" value="RSB_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS69124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="21689" checksum="4AF564D22ACFEF17" modified="2019-04-10" version="1">MKQFSRSRSKSKDRERNARRSRSRERDQRKRRDGSREKREDEKKKEKRQKEPKAEEEPPAKLLDDLFRKTKATPCIYWLPLTEEQAQQRAIQREEREKEKQKRIAAAEEREKEELKKREAARLERQKQREKERDRSRERERSGGRDRDKSRDRARGGRSDRSKGSRSRSTSRSRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H1P8</accession>
    <name>A0A3S1H1P8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">F-actin-capping protein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_021794</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
            <location evidence="1 7">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the F-actin-capping protein beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001408">
        <property type="protein sequence ID" value="RUS70445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H1P8"/>
    <dbReference type="STRING" id="188477.A0A3S1H1P8"/>
    <dbReference type="OrthoDB" id="9979678at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051490">
        <property type="term" value="P:negative regulation of filopodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010591">
        <property type="term" value="P:regulation of lamellipodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.570:FF:000001">
        <property type="entry name" value="F-actin-capping protein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.210:FF:000001">
        <property type="entry name" value="F-actin-capping protein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001698">
        <property type="entry name" value="CAPZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043175">
        <property type="entry name" value="CAPZB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019771">
        <property type="entry name" value="F-actin_capping_bsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA ISOFORMS 1 AND 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01115">
        <property type="entry name" value="F_actin_cap_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00192">
        <property type="entry name" value="FACTINCAPB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00231">
        <property type="entry name" value="F_ACTIN_CAPPING_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0117">Actin capping</keyword>
    <keyword evidence="5 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS70445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="261" mass="29465" checksum="A5935EE13614EE2E" modified="2019-04-10" version="1">MRRLPPQQIEKNLCDLIDLVPGLCEDLLSSVDQPLKIVRDKTVGKDYLLCDYNRDGDSYRSPWSNSYEPPLEDGTMPSESLRKLEIEANNAFDQYREMYFEGGVSSVYLWDLSQGFAGVILIKKAGDGSKKIKGCWDSIHVIEVQERSSGKNAHYKLTSTVMLWLQTNKEGSGTMNLGGSMTRQVESDTAVNENSPHIVNIGRMVEDMENKIRSTLNNIYFGKTRDIVNGLRSIDTLPDPAQKIAFQDDIRKVLNNRPKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HC25</accession>
    <name>A0A3S1HC25_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6451 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_015956</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000675">
        <property type="protein sequence ID" value="RUS76284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HC25"/>
    <dbReference type="STRING" id="188477.A0A3S1HC25"/>
    <dbReference type="OrthoDB" id="7384832at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045609">
        <property type="entry name" value="DUF6451"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF25">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20049">
        <property type="entry name" value="DUF6451"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6451" evidence="2">
        <location>
            <begin position="57"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6451" evidence="2">
        <location>
            <begin position="216"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS76284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="354" mass="41360" checksum="1537CEC2E603BAF6" modified="2019-04-10" version="1">MTKTEVMRVNNKQHAPIPLHQENMKEVDKFVYLGSIVSKDGGTDEDSRSRINKARHAFRTLRSVWSSSALAQHNKIRIFNSNVKSVLLYGSETWRTTKTNTQKLQTFINRCLRNILNIRWPEVISNQDLWERTRQAPIEQEIKKRKVAEEAERTGLKISMTKTEVMRVNNKQHAPIPLHQENMKEVDKFVYLGSIVSKDGGTDEDIRSRINKARHAFRTLRSVWSSSALAQHNKIRIFNSNVKSVLLYGSETWRTTKTNTQKLQTFINRCLRNILNIRWPEVISNQDLWERTRQAPIEQEIKKRKWGWMGHTLRKPSSNTTRQSLEWNPRESAKWADQDRPGGGVRTLKPGRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HD56</accession>
    <name>A0A3S1HD56_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_015248</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000619">
        <property type="protein sequence ID" value="RUS76991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HD56"/>
    <dbReference type="STRING" id="188477.A0A3S1HD56"/>
    <dbReference type="OrthoDB" id="840771at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902554">
        <property type="term" value="C:serine/threonine protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047173">
        <property type="entry name" value="STRAD_A/B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48014">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE FRAY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48014:SF21">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE FRAY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="65"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS76991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="356" mass="39879" checksum="8C78A18D861FE708" modified="2019-04-10" version="1" fragment="single">MSLLACTCGSTENDKKRPFKSSQPEQVANKEDLNKNAPETEDIVHEGEDMEEIDSSLFRPDPLQYELYAVIGKGHCNASTISLAKNFASDGLVAVKRINLEDWAGELHYFQNEILFTRMLSHPNVLPFHCSFINGQELWAVMPLMAFGSCRDLMHAYFTSGLPELAIKLIMRDVFSAVDYLHHRWIIHRGIKASHVLISKNGRVCLSGLHNVYYTIQNGQRLQNVHDFPIHAKDCLHSYSPELLAQNLAGYDFKSDVYSLGILICELANGQAPFADLPATAMLLEKLKGTKPHLADSTTVSEFVIDDDGEFPVPEGMEDQATSSQERADAIFFKRTFSPHLHELAAACLETDPQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HLD5</accession>
    <name>A0A3S1HLD5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Tartrate-resistant acid phosphatase type 5</fullName>
            <ecNumber evidence="2 6">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_010387</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="7">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="2 6"/>
    <dbReference type="EMBL" id="RQTK01000317">
        <property type="protein sequence ID" value="RUS81864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HLD5"/>
    <dbReference type="STRING" id="188477.A0A3S1HLD5"/>
    <dbReference type="OrthoDB" id="411211at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07378">
        <property type="entry name" value="MPP_ACP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000062">
        <property type="entry name" value="Tartrate-resistant acid phosphatase type 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024927">
        <property type="entry name" value="Acid_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051558">
        <property type="entry name" value="Metallophosphoesterase_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10161">
        <property type="entry name" value="TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10161:SF14">
        <property type="entry name" value="TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000898">
        <property type="entry name" value="Acid_Ptase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="10">
        <location>
            <begin position="38"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="9">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="172"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000898-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000898-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS81864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="340" mass="38485" checksum="5663336F2876C1D0" modified="2019-04-10" version="1">MTQKVSCDQLILCKMSARGVLVLLLVFLFQGSNAVDSLRFLIIGDMGGLPISPYSTYFERCTAKEMGNVADRYAPQYIIGLGDNFYFTGVDNVTDPRFKQTFEDVYIAESLQVPWYMIAGNHDHYGNATAQIHYSQHSERWNFPDFYYYKEFPIKGSDKSLGILFIDTILLCGNTDDDSSPEPPKGPADPLKAEDQWSFIDKSLQTSKAHFLLVAGHFPVYSIAEHGPTKCLVDKLQPMLENYNVNGYLCGHDHNLQHLQVTSSKGNAIDYYLSGMANFVDFRETHKDDVPPNSLKFHYANIFSKGGFLYTEATAQNMTMTFINALGERLYTNVIYPRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SIC7</accession>
    <name>A0A433SIC7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">7TM GPCR serpentine receptor class x (Srx) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_023553</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01002103">
        <property type="protein sequence ID" value="RUS68685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SIC7"/>
    <dbReference type="OrthoDB" id="6117694at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019430">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10328">
        <property type="entry name" value="7TM_GPCR_Srx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="7TM GPCR serpentine receptor class x (Srx)" evidence="2">
        <location>
            <begin position="51"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS68685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="184" mass="20144" checksum="E2E1712A9B77BC60" modified="2019-05-08" version="1" fragment="single">AGGTMHNSTSAPVLTITALVYGLGTSSSPSYDIPEWLFSYLTEFISYTMVTVTFFGLIGNTIIIITLVKIGFVTPINISFFALCISDCLCIVSIAWSAICNIPALAESDLPFKTKEVAKPTGGTKSNIFWKTAWITAFISLERCICVVFPLKIKKIVSPGKTLFSVCIYISLTCLYIHTILQFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SII8</accession>
    <name>A0A433SII8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_023517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01002067">
        <property type="protein sequence ID" value="RUS68719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SII8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS68719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="136" mass="15670" checksum="DFE6F5E6384C3690" modified="2019-05-08" version="1" fragment="single">CKLFMPSQNAMSRCKLFMPSQNATSKCKLFMPSQNTMSRCKLFMPSQNTMSRCKLFMPSQNATSKCKLFKPSQNTMSRCKLFMPSQNAMSRCKLFMPSQNATVKCKLFKPSQNTMSRCKLFMLSQNAMSRCKLFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SIW3</accession>
    <name>A0A433SIW3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_023293</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001911">
        <property type="protein sequence ID" value="RUS68946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SIW3"/>
    <dbReference type="STRING" id="188477.A0A433SIW3"/>
    <dbReference type="OrthoDB" id="5975444at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000013">
        <property type="entry name" value="Membrane frizzled-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251:SF37">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="115"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS68946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="175" mass="19555" checksum="DFED5BEAD53767DB" modified="2019-05-08" version="1" fragment="single">ALSGDNGTITSPDYPHDYRNNARCVWSITVEPGKVIQLTFHQFAVEEWDDICDTDWVLIYDNSTSRDNPLGKECGFSIPEPIWSNGNQMFVESNSNVTASGFRAEWAVCENEQCCGGALSGDNGKFTSPDYPHNYTDGTRCVWSISVEPGKVIRLKFHEFDVENGSDCSLDWVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SM44</accession>
    <name>A0A433SM44_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_021989</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001452">
        <property type="protein sequence ID" value="RUS70244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SM44"/>
    <dbReference type="OrthoDB" id="10676011at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS70244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="527" mass="57580" checksum="50020C9F06D933E1" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-05-03" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SPU9</accession>
    <name>A0A433SPU9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_020963</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001242">
        <property type="protein sequence ID" value="RUS71271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SPU9"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS71271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="153" mass="17050" checksum="648E1BFDA54C3A14" modified="2019-05-08" version="1" fragment="single">IYGGFSSLCDINISSQRVYFVVVLFFSSRHETKYIIEFEIHRVCCFDIVFFSSRHETKYIIEIHTRNCDTVDKTEDERLDTCGLAELALDGPSTTGTGVTGCGPALVRMRTHCLTTTSVDTKTGRTHIVYSVSGPSSVTLYRFRNGSRTVCAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SPZ3</accession>
    <name>A0A433SPZ3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_020960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001240">
        <property type="protein sequence ID" value="RUS71283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SPZ3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS71283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="421" mass="46447" checksum="28A4DC9C994756DD" modified="2019-05-08" version="1">METVDGDDVRVGFNPETKRVVEVDVTVNETMPQEMDVIVEVGGDNKIGDALVCPEVERGIVLVEEVLQGMETVDGDDVRVGLNPETKRVVEVDVTVNETMPQELDTVGGHDVGVGLNPETKRVVEVDVTVNETMPQEMDTVGGDDVGVGLRYEKEAPGVNFSFLQTTAEIHSFGDRVSICYGDKKNSFGKFERAKTKGRPRGAGVTCNRKRKQTKCRLLPKDKRLKTVGAMKEDICGVCGKEELDKDLCEGGSLMEWIDCDMQADEKKRGRRNVAVLKLTVKWTDKRTNKSDLEEIGSPKLVLKTINNRSRTLDDLEGEGAAIASTVDESMMTSTPGRSDTPSLVLQPIVSPLKEPRLKTTPILSAAAPSRPRLHRQPITLGWVMWLPFLACEDGLVFKPDLVQIRAFLTTFWKIGIAIHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SQR1</accession>
    <name>A0A433SQR1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_020649</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001191">
        <property type="protein sequence ID" value="RUS71588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SQR1"/>
    <dbReference type="OrthoDB" id="6061253at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS71588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="516" mass="57513" checksum="E83BD9C64A2E4030" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SQU7</accession>
    <name>A0A433SQU7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_020623</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001187">
        <property type="protein sequence ID" value="RUS71612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SQU7"/>
    <dbReference type="OrthoDB" id="10690118at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="800"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="719"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="724"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS71612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="828" mass="90496" checksum="A1A6F4E4CA290AD2" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SZ60</accession>
    <name>A0A433SZ60_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_017645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000816">
        <property type="protein sequence ID" value="RUS74603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SZ60"/>
    <dbReference type="STRING" id="188477.A0A433SZ60"/>
    <dbReference type="OrthoDB" id="9625900at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS74603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="246" mass="27202" checksum="C788B42325B876EA" modified="2019-05-08" version="1">MVLQVGEMSPVSAFIPRLPDSQLYPSPVSAFIPRLPDSQLYPSPVTAFIPRLPDSHLYPSPVTAFIPRLPDSHLYPSPLTAFIPRLPDSHLYPSPVTAFIPQPSDPHLYPSPVSAFIPRLPDSHLYPSPVSAFIPRQPDSHLYPSPFSVHELHPCPQLELVSDTAFSISPVCLYLYPQVLSQSPQSDFDCLSVSLYPILILLPAIYVQSFAQPSVCLSVYVLTPILIPLSAIYVVLCPNPLYVIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T1M2</accession>
    <name>A0A433T1M2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Macroglobulin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_016803</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000743">
        <property type="protein sequence ID" value="RUS75424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T1M2"/>
    <dbReference type="STRING" id="188477.A0A433T1M2"/>
    <dbReference type="OrthoDB" id="6359008at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF136">
        <property type="entry name" value="CD109 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0882">Thioester bond</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019232766" description="Macroglobulin domain-containing protein" evidence="3">
        <location>
            <begin position="28"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS75424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="26075" checksum="90F5651ABE34B45E" modified="2019-05-08" version="1">MSSGCVKPLTMWLQVALTAVLFSLGTTQVLNQQEENCLLDSTAGCSFARSPEYMIITPRRIRPMQVFQVFVSILHMKTYQEHVYVHVSIIRDDEEYAGSVLRFDRPSSRIMQLQMPDSAQEGHYKLRVEGRLQESAMGNIWHNETDIELFNKQASLFMQMSKPMYRQGQRVHFRVIPILPNMMPKYGSMIIYIDDPTGFPVRRWQGLQTNAGGLLHLLFYGKKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T213</accession>
    <name>A0A433T213_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_016698</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000732">
        <property type="protein sequence ID" value="RUS75530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T213"/>
    <dbReference type="STRING" id="188477.A0A433T213"/>
    <dbReference type="OrthoDB" id="298939at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002031">
        <property type="term" value="P:G protein-coupled receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000036">
        <property type="entry name" value="beta-arrestin-2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.840:FF:000003">
        <property type="entry name" value="Kurtz arrestin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000698">
        <property type="entry name" value="Arrestin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017864">
        <property type="entry name" value="Arrestin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014753">
        <property type="entry name" value="Arrestin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11792">
        <property type="entry name" value="ARRESTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11792:SF17">
        <property type="entry name" value="KURTZ ARRESTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00309">
        <property type="entry name" value="ARRESTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00295">
        <property type="entry name" value="ARRESTINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="3">
        <location>
            <begin position="214"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="371"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS75530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="405" mass="44545" checksum="22015664622D5937" modified="2019-05-08" version="1">MAGLSGQNGPLNSSTDDTSKKQGTRVFKKSSPNGKITTYLGKRDFVDHLSHIDPVDGVILVDPEYLKDRKVFAHILAAFRYGREDLDVLGLTFRKDLYISSLQVYPPLKDSKEAARPLTRLQERLIKKLGPNAYPFFFELPPNSPASVTLQPAPGDTGKPCGVDYELKTFVADMIDGKPHKRNSVRLAIRKLTYAPEEPAPQPNAEAVKDFIMSPGSIRLEASLDKEKYYHGESMAVNVLVDNNTNKTVKKVKISVRQFADICLFSTAQYKCAVADLESEEGFPIQPSQTGFCKVYHLTPLLSNNRDKRGLALDGKLKHEDTNLASSTIMTEKSQKEGLGIVVSYRVKVKLIMGFGSGELAVELPFTLTHPKPPDSPAPSRSASIAPTEAGDAPLDTNLIQLDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T3X5</accession>
    <name>A0A433T3X5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EGW08_016007</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">EC2010</strain>
            <tissue evidence="17">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000679">
        <property type="protein sequence ID" value="RUS76234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T3X5"/>
    <dbReference type="STRING" id="188477.A0A433T3X5"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901029">
        <property type="term" value="P:negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000096">
        <property type="entry name" value="ADP,ATP carrier protein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="8"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="112"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="211"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RUS76234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="306" mass="33366" checksum="C92B49E345D522ED" modified="2019-05-08" version="1">MPEKKPKLGFAENFALSGAAAVISKTAAAPIERIKLLVQNQDEMIKAGRLSEPYKGVVDCTVRTFRTEGLLPFWRGNLANCLRYFPTQALNFAFKDTIKAMFKSAPNEAYAMKFTKNIFSGGAAGALSLCFVYSLDYARTRLANDAKSAGKGGGERQFNGLVDVYRKTIASDGIVGLYRGFVISCVGIVVYRGFYFGLYDSLKPILLAEDASVFLSFALGYTVTVSSGLLSYPIDTIRRRMMMTSGQAVKYKGSMDCAVKIIKGEGFMSLMKGAGANILRGVAGAGVLSGFDKFKELYLKWRLTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T6P8</accession>
    <name>A0A433T6P8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_014992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000596">
        <property type="protein sequence ID" value="RUS77239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T6P8"/>
    <dbReference type="OrthoDB" id="6134941at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS77239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="276" mass="31904" checksum="F6EA807A3D389E3C" modified="2019-05-08" version="1" fragment="single">SLDATPGLRTLCIKFLVALHQQLQKQPRHKFLTNYLHFESPIRQQQANVKKVKNCHACERYLRITSDIRECGICKQVFCMACTWKTLQLYLPKGTDLRADIQLEMIRFHVKETEVVGKGEVTAIEASEVYRVCASCEDVVARNIHVNEFDAKVPELEAELFDLQRQIDHCLTFSPYMLGIQRSASAAQLNKLEEENFMATCMKHANSLYERYTRTYDILNKLMPQTGGQKALHKHIKQAMYDFYLKRRDQLKTTLRRRDSCEGIPAENTAPDDAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T881</accession>
    <name>A0A433T881_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="9">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_014456</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="9">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="9"/>
    <dbReference type="EMBL" id="RQTK01000552">
        <property type="protein sequence ID" value="RUS77792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T881"/>
    <dbReference type="STRING" id="188477.A0A433T881"/>
    <dbReference type="OrthoDB" id="7396459at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001022">
        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056330">
        <property type="entry name" value="CTT_SPB4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23681">
        <property type="entry name" value="CTT_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="146"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="387"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="420"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS77792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="477" mass="54298" checksum="718CF1EE60AA3E44" modified="2019-05-08" version="1">MPQFSSCLFIGGTTIQADVEKFVNKGGNIIIATPGRLEDLFQRKQPGFHLAASVKSLQILILDEADRLLDMGFEASITTILGYLPKQRRTGLFSATQTDEVEKLIRAGLRNPMQITVKEKSREANGGQRTPSSLKNYYMLMEADQKFSQLVQFLSSRRKEKVMVFFSTCACVDYFSKCLEIILKKIQIFAIHSKMKSKRNHIFSTFRKQKSGVLICTDVMARGVDIPEVNWVIQYDPPSSASAFVHRCGRTARIGNTGNALVMLLPSEDAYVKFIEINQRVPLQELPKVEEAPEMCTVLQTLAINDRAVYEKGVRAFVSYIQSYVKHECNMILRLKDLDFGKLAQGFGLLHLPKMPELKGKRVVNFEPIEVDLSTIPFKDKAREKLRQEKAESEAAEKKVKRTRPPRSIPWSKNKEKLDKRKSKKEVRKTKAEKRKASTNDDDIVDDFDDDIRLMKKLKKGKISKEEFDATFAPDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TA70</accession>
    <name>A0A433TA70_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">small monomeric GTPase</fullName>
            <ecNumber evidence="3">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_013794</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="3"/>
    <dbReference type="EMBL" id="RQTK01000509">
        <property type="protein sequence ID" value="RUS78448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TA70"/>
    <dbReference type="STRING" id="188477.A0A433TA70"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04139">
        <property type="entry name" value="RalA_RalB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000203">
        <property type="entry name" value="Putative ras-related protein ral-a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS78448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="202" mass="23187" checksum="8F06698BF2558B2D" modified="2019-05-08" version="1">MSKAKAQQPAVIHKVIMVGSGGVGKSALTLQFMYDEFIEDYEPTKADSYRKKVVLDGEEVQIDILDTAGQEDYAAIRDNYFRSGEGFLCVFSIKEQESFQATQDFREQILRVKNDENIPFLLVGNMADLAEQRQVSEDEALKRAQEWKVHYVETSAKTRANVDKVFYDLMREIRSRKMEASRQSNGKQNKNRTSKKIKCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TEF0</accession>
    <name>A0A433TEF0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_012286</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000419">
        <property type="protein sequence ID" value="RUS79942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TEF0"/>
    <dbReference type="OrthoDB" id="5990677at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019327345" evidence="2">
        <location>
            <begin position="21"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS79942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="137" mass="13191" checksum="472349BB27F33633" modified="2019-05-08" version="1">MKISVRILCFLAVILACVSAQTGVMNQGPGSNQGQALPGSNQAALNPSQGLPGSNQGYPAPSQALPGSTQGSLIPSQALPGSNQGPLIPSQGLPGSNQGSPAPSQALPGSTQGSPAPSQALPGSTQGSPGLGCKALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TH69</accession>
    <name>A0A433TH69_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyrosine-protein kinase ephrin type A/B receptor-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_011309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000365">
        <property type="protein sequence ID" value="RUS80928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TH69"/>
    <dbReference type="STRING" id="188477.A0A433TH69"/>
    <dbReference type="OrthoDB" id="439917at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47236:SF4">
        <property type="entry name" value="GENE 9195-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47236">
        <property type="entry name" value="GENE, 32742-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS80928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="12143" checksum="6E1CF77C832E3984" modified="2019-05-08" version="1" fragment="single">MYASRICPAGVECPPGMARQPDLVSDKCRVGHYCPAGDVSAYPVACPVGTYNPDFGRQELADCVQCTPGMYCTPTGLSAPAGDCPGGYYCPLGTGPADSYPCPIGFYRNNSANEAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TIY8</accession>
    <name>A0A433TIY8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_010690</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000331">
        <property type="protein sequence ID" value="RUS81560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TIY8"/>
    <dbReference type="STRING" id="188477.A0A433TIY8"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="92"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="752"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="896"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="758"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="929"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="972"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS81560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1007" mass="110895" checksum="8E2579680CF98861" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TKJ2</accession>
    <name>A0A433TKJ2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EGW08_010207</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">EC2010</strain>
            <tissue evidence="15">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000308">
        <property type="protein sequence ID" value="RUS82016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TKJ2"/>
    <dbReference type="STRING" id="188477.A0A433TKJ2"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030048">
        <property type="term" value="P:actin filament-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21759">
        <property type="entry name" value="CBD_MYO6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01382">
        <property type="entry name" value="MYSc_Myo6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21958">
        <property type="entry name" value="MyUb_Myo6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000006">
        <property type="entry name" value="Putative unconventional myosin-VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1590:FF:000002">
        <property type="entry name" value="unconventional myosin-VI isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000018">
        <property type="entry name" value="unconventional myosin-VI isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.360">
        <property type="entry name" value="Myosin S1 fragment, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049016">
        <property type="entry name" value="MYO6_lever"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032412">
        <property type="entry name" value="Myosin-VI_CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008989">
        <property type="entry name" value="Myosin_S1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036114">
        <property type="entry name" value="MYSc_Myo6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF745">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21521">
        <property type="entry name" value="MYO6_lever"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16521">
        <property type="entry name" value="Myosin-VI_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8 11" id="KW-0518">Myosin</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="14">
        <location>
            <begin position="2"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="13">
        <location>
            <begin position="57"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="11">
        <location>
            <begin position="646"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="934"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1093"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="934"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="151"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RUS82016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1242" mass="142749" checksum="2A4EFA926A4E7A45" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TPD7</accession>
    <name>A0A433TPD7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_008800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000243">
        <property type="protein sequence ID" value="RUS83428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TPD7"/>
    <dbReference type="OrthoDB" id="10544855at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS83428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="96" mass="10851" checksum="4215B4DAC630D4A7" modified="2019-05-08" version="1" fragment="single">DKGANNASKLHDAVLVWVSQVHWLRVVGVHQGQETVHQIADVLERPHKTISYSYRDGFVLQSLQDKVADHSAIVHVHSRTECVENTSNSNFHIFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TPE8</accession>
    <name>A0A433TPE8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U5 small nuclear ribonucleoprotein 40 kDa protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">WD repeat-containing protein 57</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_008775</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing as component of the activated spliceosome. Component of the U5 small nuclear ribonucleoprotein (snRNP) complex and the U4/U6-U5 tri-snRNP complex, building blocks of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the pre-catalytic and catalytic spliceosome complexes. Component of the postcatalytic spliceosome P complex. Part of the U5 snRNP complex. Interacts with PRPF8. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, WDR57, SNRNP40, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39. Component of the minor spliceosome, which splices U12-type introns.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000242">
        <property type="protein sequence ID" value="RUS83459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TPE8"/>
    <dbReference type="STRING" id="188477.A0A433TPE8"/>
    <dbReference type="OrthoDB" id="1068471at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000375">
        <property type="term" value="P:RNA splicing, via transesterification reactions"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000229">
        <property type="entry name" value="Small nuclear ribonucleoprotein U5 subunit 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052234">
        <property type="entry name" value="U5_snRNP_Component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006:SF1">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="51"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="94"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="136"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="185"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="220"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="281"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="312"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00057342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00064268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS83459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="346" mass="38161" checksum="863CA2F1EA506A49" modified="2019-05-08" version="1">MDLKRKATEGAIVPFKKPRNELVAATTSSSGAVLPAGPPRTSNLLAPIMLLTGHEGDIFCGKFSPDGQLFASAGFDRLIYFWTVYGECENFAMLKGHTGAIMELQFSTDGSLLFSGSTDKIVAVWDIESGERLRKLKGHQTFVNTVSPARRGPQLLCSGSDDGTVKMWDARKKGCLNTFQCTYQVTSVTFNDTAEQIISGGIDNELKVWDLRKNAVLYKMRGHSDTVTGLELSPEGSYLLSNSMDNTLRIWDVRPFAPQERCVKIMSGHQHTFEKNLLRCAWSPDGSRVSAGSGDRYVYVWDTTSRRVLYKLPGHAGSVNEVDFHPTEPVISSCSSDKKVFLGELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TRC7</accession>
    <name>A0A433TRC7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_008060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000215">
        <property type="protein sequence ID" value="RUS84173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TRC7"/>
    <dbReference type="STRING" id="188477.A0A433TRC7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS84173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="170" mass="18574" checksum="057E9DCB3FCF782A" modified="2019-05-08" version="1">MMVMIREENVMEMMGILQSARREGGDGDDARREGGDDGDDARREGGDGDTSRREGGDDGDDPRREGSDDGDTAKFKERREVGDGGDDARREDGDDARREGGDGGDDARREDGDDGDDVRREDGDGGDDARREVGMVVMMQGENVEMMAMIPGEKMVMNTLGTSSFLWNIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TRH3</accession>
    <name>A0A433TRH3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_008127</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000218">
        <property type="protein sequence ID" value="RUS84088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TRH3"/>
    <dbReference type="STRING" id="188477.A0A433TRH3"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005335">
        <property type="term" value="F:serotonin:sodium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015842">
        <property type="term" value="P:aminergic neurotransmitter loading into synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF4">
        <property type="entry name" value="PORTABELLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="148"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="193"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS84088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="522" mass="57520" checksum="F8E1AAC5BD763D9A" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TVS6</accession>
    <name>A0A433TVS6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_006549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000162">
        <property type="protein sequence ID" value="RUS85673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A433TVS6"/>
    <dbReference type="OrthoDB" id="6161073at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS85673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="275" mass="28306" checksum="DF114C63B646967B" modified="2019-05-08" version="1">MTKTIELHSCNKKVCALINPVENSTHLDSGEGEGEGEGDTIYGKHKKCTDYEKTIYVKQILKYDDKKIGTLAGLKSGGTLPGLKSGGTLPGLKSCGTLPGLKSGGTLPGLKSGGTLPGMKSGGTLPGMKSGGTLPGMKSGGTLPGLKSGGTLPGMKSGGTLPGMKSGGTLPGXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXSDYAETGCPLGLSDYAETGCPLSVSGNLWGDETTERESNRGPSAVCLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TW79</accession>
    <name>A0A433TW79_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_006392</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000158">
        <property type="protein sequence ID" value="RUS85840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TW79"/>
    <dbReference type="OrthoDB" id="5977230at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="172"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="219"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS85840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="336" mass="37449" checksum="28F4A78D95E53975" modified="2019-05-08" version="1">MKDNYYLIRTFRLAISNQNLQLMEVKPRQRDIIVPPKLSDRTTPKVLIPSPVPTDMKPTTSIFDSIVKRSTANQFIVPPTIRSSDNVHLNLMVPPTISSSQTGNNAGNSQPSSQVVGILNSQPRVVCYADQPIDRDVPCPGDHNTSLGVQHMQSILKLMGGSDIKHTMVMKDPTVTPSTDLNNDDHSSASPVSRPNHTFPATPSEDTTDDAETMVRRVTNFLENRVTILEQLLDEANIDVIQCEENIEKLEKAIPTKRRKRRSIIGTSDVTCQSQGERIGGGNLLNLCSTCVQTTVLNENFFPRYITEKVEHQFLREFAVSNFSTSTSLNEFQENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TWL7</accession>
    <name>A0A433TWL7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Reverse transcriptase RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_006261</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000154">
        <property type="protein sequence ID" value="RUS85991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TWL7"/>
    <dbReference type="STRING" id="188477.A0A433TWL7"/>
    <dbReference type="OrthoDB" id="6160665at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="7">
        <location>
            <begin position="13"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="7">
        <location>
            <begin position="213"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS85991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="446" mass="50270" checksum="48795945256CEF9C" modified="2019-05-08" version="1">MVVSELVLTHYYPSLPLKLATDASPYGLGAVISHVTEEGERPISFASRTLSKAEQGYSQLDKKALAIVWAVKKFLFYLCGRHFTLITDHQPLKYIFSPDKGIPAMSAVRQQRYAVFLSGFNYSIEYRNSKANANADSLSRLPLPVSDTDSETIDDTDELYYQEVVDSIPVSANSIAKESRHDFTIARVLNYVTKDDWIAQNHYTIFCRTTLHSIATDASPYGLGAVISHVTEEGERPISFASRTLSKAEQGYSQLDKEALAIVWAVKKFFYLCGRHFTLPDHQPLKYIFSPDKGIPAMSAARQQRYAVFLSGFNYSIEYRNSKANANVDSLSRLPLPVSDTESESETSDDTDELYYQEVVESIPVSAKPITKVSRHDLTIARVLSFVIKDDWPSSIEPELRPFTSEDMNLVYNKNVYSGAIESFHHGNSNNKYCKHCTKAIWELLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U012</accession>
    <name>A0A433U012_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_005095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000118">
        <property type="protein sequence ID" value="RUS87163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U012"/>
    <dbReference type="OrthoDB" id="6085254at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34239">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34239:SF2">
        <property type="entry name" value="TRANSPOSABLE ELEMENT P TRANSPOSASE_THAP9 CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS87163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="341" mass="37644" checksum="8C12A914FF714139" modified="2019-05-08" version="1">MADSGEHYTLASVAQDLRGTVAELLKHSKPVTRRRDRSPSPSGSGPSRPRKALKETGGGERDTGSVSPQDCTSVPECPGLVDLDNLSVLSEGEVYDNSISNLEAFYGFHDQEGDKVDDKLIQIVDAGLCKKPDEAKTKDLLEQYPKPVNSKNLRVPKTNVEVLKLLTKNQRLRDIRLQKSQTIITKSLTASVKLLAGLREARKGNSAMNLKSCINIANDIVRLNSASYSDLSALRKDNMRSGLADVYKPLCGDLTTQSDSTELLFGTDLPQKIKDLGESSKMASNIGAPKNFNRSRPYKFQSGSDSKQPKYHNQSRRRFAGQKQGGKQPFSHQWKAKNWPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U274</accession>
    <name>A0A433U274_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_004338</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000097">
        <property type="protein sequence ID" value="RUS87922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U274"/>
    <dbReference type="OrthoDB" id="6128546at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS87922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="16030" checksum="5A6B081C5D8E4DD1" modified="2019-05-08" version="1">MVFINGYRSVAIALIVPAIITTLMHISEGVDVNAPLDLFHLGDKDNNSALSMDECSKMWLTLDVDGDDAIGKIEFIFKWTFANFPDSERAPLFLRLVDNDFDGLVSMEEIGKLCRFFDDDDNFSISMQEFQLNWTGMFRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U3N9</accession>
    <name>A0A433U3N9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_003856</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="RQTK01000084">
        <property type="protein sequence ID" value="RUS88400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U3N9"/>
    <dbReference type="STRING" id="188477.A0A433U3N9"/>
    <dbReference type="OrthoDB" id="6129151at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="27"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="261"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS88400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="627" mass="69568" checksum="CB9F29BBE719B74E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U4T3</accession>
    <name>A0A433U4T3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tyrosine-protein phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_003381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000072">
        <property type="protein sequence ID" value="RUS88836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U4T3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS88836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="295" mass="31814" checksum="CCB9FD8E81F49698" modified="2019-05-08" version="1">MFYCSTPGPPRPPCVGGASRYCNGADQCGLMCVQSILLDKLQTDQYVAVPVVVGAIKAIRPQVIPTEDQYKCLYATLRLAQELQVKPSQLTHHTTPGVGPTNADPTGDVYCNVGSLEGVTSSRERNTRPGVTATALNSGRAEGCLPSTSLQQQSSRSSPSSAAQSSPQNHNQQSQPDAQIINEPAEEIKAHAHTANSQTQNSDDKVEYSNYAAQNSDALVEYSVPKTPNSDHAVEYSIPVARNSDIEVEYSIPKAQNFDAVAQKPETIAEYSNFFDQNSETVAEYGNFASLQNQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2024-05-29" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U4Y7</accession>
    <name>A0A433U4Y7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_003325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000071">
        <property type="protein sequence ID" value="RUS88886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U4Y7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS88886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="103" mass="11711" checksum="36BD4B5589B164D3" modified="2019-05-08" version="1">MKLAFSFHNQILQRSKTGSNPFHCSTYTIELASSFHNQILLRSKTGSNPFQCSTYTISCSTCTLSILQTQTNHSSFLFVLLDWRVTFKVKNSVEHHVCTLSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U8B5</accession>
    <name>A0A433U8B5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRO1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_002160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000041">
        <property type="protein sequence ID" value="RUS90047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U8B5"/>
    <dbReference type="STRING" id="188477.A0A433U8B5"/>
    <dbReference type="OrthoDB" id="2141925at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09240">
        <property type="entry name" value="BRO1_Alix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09235">
        <property type="entry name" value="V_Alix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.280:FF:000001">
        <property type="entry name" value="programmed cell death 6-interacting protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF39">
        <property type="entry name" value="PROGRAMMED CELL DEATH 6-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="2">
        <location>
            <begin position="3"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="717"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="734"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="755"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="771"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="869"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="898"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="909"/>
            <end position="928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS90047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="928" mass="101904" checksum="B007EAC1288E27D5" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U977</accession>
    <name>A0A433U977_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_001857</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000034">
        <property type="protein sequence ID" value="RUS90362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U977"/>
    <dbReference type="STRING" id="188477.A0A433U977"/>
    <dbReference type="OrthoDB" id="6136996at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050784">
        <property type="entry name" value="IAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044:SF139">
        <property type="entry name" value="DEATH-ASSOCIATED INHIBITOR OF APOPTOSIS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044">
        <property type="entry name" value="INHIBITOR OF APOPTOSIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01282">
        <property type="entry name" value="BIR_REPEAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS90362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="347" mass="39084" checksum="07199880B9BCAF34" modified="2019-05-08" version="1">MQRNAPNGYVPIEVISGYREGDNGEMEMEYERVFVQRPPDGVFNEPLDQGPELSSASSVSRPSARQLYAEKERLATFQGRWSPDYPVKPRDLARDGLYYIGPGDKVKCVFCQKVLRGWDPGDVVEQEHRRIYPNCPWVLGRCQEMNVPLNSTDTMQRSYGVSLRQEEGQHPMQELGSRLKTFDGKWPPSVPVDPRLIAEAGLFYIGDKDKTKCFQCNNIIQRWEAGDDPWREHAKLYPNCPYVLGVKGREFVEAVANSAQAVVEAPTQVSAGASQTQQSQGAEAASITEQMARMHIDDDMNSPAVLAFMDIFGEVPVSRIRQLLERIRLEKGPSYKLSSADLEPLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UEF8</accession>
    <name>A0A433UEF8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fucolectin tachylectin-4 pentraxin-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_000058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000001">
        <property type="protein sequence ID" value="RUS92205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UEF8"/>
    <dbReference type="OrthoDB" id="6132992at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051941">
        <property type="entry name" value="BG_Antigen-Binding_Lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45713:SF6">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45713">
        <property type="entry name" value="FTP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22633">
        <property type="entry name" value="F5_F8_type_C_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019222182" description="Fucolectin tachylectin-4 pentraxin-1 domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS92205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="690" mass="74600" checksum="6AC151E716D124B7" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z2V5</accession>
    <name>A0A3S0Z2V5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_022680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001639">
        <property type="protein sequence ID" value="RUS69558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z2V5"/>
    <dbReference type="STRING" id="188477.A0A3S0Z2V5"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS69558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="253" mass="29788" checksum="E69578606CBA13F9" modified="2019-04-10" version="1" fragment="single">LSYLILSYLILSYLILSYLILSYLILSYLILSYLILSYLILSYLILSYLILSYLILSYLILSYLILSYLILSYLILSYLILSYLILSYLILSYLILSYLILSYLILSYLILSYLILSYLILSYLILSYLILSYLILSYLILSYLILSYLILSYLILSYLILSYLILSYLILSYLILSYLILSYLILSYLILSYLILSYLILSYLILSYLILSYLILSYLILSYLILSYLILSYLILSYLILSYLILSYLIAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z568</accession>
    <name>A0A3S0Z568_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_022622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001621">
        <property type="protein sequence ID" value="RUS69618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z568"/>
    <dbReference type="STRING" id="188477.A0A3S0Z568"/>
    <dbReference type="OrthoDB" id="10059790at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS69618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="31125" checksum="8B9C81FD4D2C83DF" modified="2019-04-10" version="1">MSSLTKLPISPQCIPLEEMSSLTKLPISPQCIPLEEMSSLTKLPISPQCIPLEEMSSLTKLPISPQCIPLEEMSSLTKLPISPQCIPLEEMSSLTVHSLGRDEQTLELTAACPQPAHQHDSRRPDQAATIRREPRGPSPALLRARLWDGRSAPDSSAGPGPACKVCQAEYRGHLQQVEGHVFSGPSRSSWRILTADDINRLSQKQQDAHEKLYHVAEGAEKTGLQINIRKTEAMRMNIKQANALRLHDENIEEVDKFVYLGSVSKDGGTDEDIRCRINKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z7V3</accession>
    <name>A0A3S0Z7V3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_020885</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001228">
        <property type="protein sequence ID" value="RUS71355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z7V3"/>
    <dbReference type="STRING" id="188477.A0A3S0Z7V3"/>
    <dbReference type="OrthoDB" id="424302at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF10">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS71355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="189" mass="20630" checksum="596C28DF2CDC5DD1" modified="2019-04-10" version="1">MSEEKNPPSSDMAKFREFFSKAKHIVVLTGAGVSAESGVPTFRGAGGLWRKWKAQDLATPEAFASNPSLVWEFYHYRREVMSSKHPNKAHIAIAECEKRLKPQGRRVVVITQNIDELHKRAGSENILELHGNLFTTRCTKCGDVSVNKDSPICPALAGKGGGGEGGAQGSQNKCNNTFELPHSYSANFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z9M1</accession>
    <name>A0A3S0Z9M1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase</fullName>
            <ecNumber evidence="9">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EGW08_018364</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">EC2010</strain>
            <tissue evidence="17">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="11">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="9"/>
    <dbReference type="EMBL" id="RQTK01000891">
        <property type="protein sequence ID" value="RUS73878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S0Z9M1"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13361">
        <property type="entry name" value="PH_PLC_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08591">
        <property type="entry name" value="PI-PLCc_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000008">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000031">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000005">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1230.10">
        <property type="entry name" value="Phospholipase C beta, distal C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016280">
        <property type="entry name" value="PLC-beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014815">
        <property type="entry name" value="PLC-beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042531">
        <property type="entry name" value="PLC-beta_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037862">
        <property type="entry name" value="PLC-beta_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053945">
        <property type="entry name" value="PLCB1-4-like_EFh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF149">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17787">
        <property type="entry name" value="PH_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08703">
        <property type="entry name" value="PLC-beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22631">
        <property type="entry name" value="PLCB1-4-like_EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000956">
        <property type="entry name" value="PLC-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69989">
        <property type="entry name" value="C-terminal domain of PLC-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9 12" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7 9 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="16">
        <location>
            <begin position="479"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="15">
        <location>
            <begin position="595"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="420"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="777"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1192"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="944"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="789"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="878"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1192"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1213"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1225"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1254"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1269"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000956-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000956-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RUS73878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1304" mass="147348" checksum="973484B97F19B9A5" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZB38</accession>
    <name>A0A3S0ZB38_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kazal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_018581</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000913">
        <property type="protein sequence ID" value="RUS73649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZB38"/>
    <dbReference type="OrthoDB" id="126772at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050653">
        <property type="entry name" value="Prot_Inhib_GrowthFact_Antg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10913:SF45">
        <property type="entry name" value="FOLLISTATIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10913">
        <property type="entry name" value="FOLLISTATIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00050">
        <property type="entry name" value="Kazal_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="Kazal-like" evidence="4">
        <location>
            <begin position="75"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="4">
        <location>
            <begin position="137"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS73649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="173" mass="17541" checksum="C6CC357BC924519C" modified="2019-04-10" version="1" fragment="single">CLYTKAHCKDVDLKPVDCNAAGNQVTTTSTGVTNPPVATNAPGTVTTNGMVQVNGTADVPANTFLTTTTATATLSNLGVVCQTLLANPCPPDNSPVCASDLVSYANLCEYTKARCLKPGLTVVQQGACTAITTPAPDVAGIVCNALAASACFDDAIVLCGSDGITYSNSCLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZFQ6</accession>
    <name>A0A3S0ZFQ6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_015690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000653">
        <property type="protein sequence ID" value="RUS76558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZFQ6"/>
    <dbReference type="STRING" id="188477.A0A3S0ZFQ6"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050129">
        <property type="entry name" value="Zn_alcohol_dh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401:SF2">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="24"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS76558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="361" mass="38761" checksum="27198D6FC7074A15" modified="2019-04-10" version="1">MQEKKMASVDIPATMKALVKKEEGESYSYVTVPVEEPGQGEVLIKVDCVSICGSDIALYKWDNVARLIATVPFIPGHECAGTVVKCGPGADIPVGTKVGVENHFFCGDCFQCRYEDGAICSNMGQYGHGKQTQQGGCSEYSVVPAKYLYALTRDLDAEQIAMLEPLGVAHNAIEKLGVKGKEVLVIGCGPVGLMAQASAKALGAKKVLGVDIEDKKLKLATQLGADIVINSMSQDLKEFVMKHTSGVGMDCVCECSGASSMVNSSFSLLRKGGHIGLVGLPKQPLHVENVLQDVVFKALTLKTVHGRLIFHTWRETEVLVAEGKIDVKAIISHRFPMSQFEEAFKVLMSGQACKIVLDPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZH08</accession>
    <name>A0A3S0ZH08_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_014817</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000581">
        <property type="protein sequence ID" value="RUS77439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZH08"/>
    <dbReference type="OrthoDB" id="6096265at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018543256" description="EF-hand domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="42"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="97"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS77439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="143" mass="16409" checksum="794CC51066EC9DAB" modified="2019-04-10" version="1">MNSLYVLLLVLPAAALAIDLKPYNETAHMMFIESDFNSDGMFTRDELDMVFKGYDTNGDGRVTRHEYTSYVDLHTPTLHDLSHALYDIYDSDNDHHLDKHDYDLLFATMDADSDGIVQEMEFRIYWTALYGSLETVHGHGSHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZJ30</accession>
    <name>A0A3S0ZJ30_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_012122</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000410">
        <property type="protein sequence ID" value="RUS80123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZJ30"/>
    <dbReference type="STRING" id="188477.A0A3S0ZJ30"/>
    <dbReference type="OrthoDB" id="2019504at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010301">
        <property type="entry name" value="RRP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026">
        <property type="entry name" value="NNP-1 PROTEIN NOVEL NUCLEAR PROTEIN 1 NOP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05997">
        <property type="entry name" value="Nop52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="228"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="361"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="647"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="719"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="246"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="395"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="411"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="551"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="581"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="619"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="666"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="719"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="746"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS80123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="876" mass="96782" checksum="54246FD9C61D7439" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZKB2</accession>
    <name>A0A3S0ZKB2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_011359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000368">
        <property type="protein sequence ID" value="RUS80888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZKB2"/>
    <dbReference type="STRING" id="188477.A0A3S0ZKB2"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35001">
        <property type="entry name" value="COLLAGEN IV NC1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35001:SF5">
        <property type="entry name" value="PROTEIN CBG01852"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS80888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="214" mass="22843" checksum="FD09170217283095" modified="2019-04-10" version="1">MVCAGIENREGKTFIGPSVLLSSPQFSSILLNSPQFFSVFLSSSQFSSVLLSSPQFSSVLFSSPQFSSIFLSSPQFSSVLLNSPQFSSVLLNAPQFSSVLLSSPQFSSVLLSFPQFFSVLLSSPQFSSVPLSSSQFFSVLLSSSLLSSVLLTSALFTSVLLSSPQFSSVLLSSPQFSSILLSSPQFSSVLLSSPQFSSVLLSFPPRSGPLARRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZKP1</accession>
    <name>A0A3S0ZKP1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_015138</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIX/Sine oculis homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000610">
        <property type="protein sequence ID" value="RUS77101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZKP1"/>
    <dbReference type="STRING" id="188477.A0A3S0ZKP1"/>
    <dbReference type="OrthoDB" id="3501850at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000063">
        <property type="entry name" value="SIX homeobox 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031701">
        <property type="entry name" value="SIX1_SD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390">
        <property type="entry name" value="HOMEOBOX PROTEIN SIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390:SF61">
        <property type="entry name" value="HOMEOBOX PROTEIN SIX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16878">
        <property type="entry name" value="SIX1_SD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="154"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="156"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="199"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="337"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS77101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="391" mass="42268" checksum="3CCECB29A08D9261" modified="2019-04-10" version="1">MLHDQPSTIGLMGGGGASGGGGSGAGGGSPSGGSMLPSFGFTQEQVACVCEVLQQGGNIDRLARFLWSLPACEHLHKNESVLKAKAVVAFHRGNFKELYKLLENNQFSPHNHPKLQALWLKAHYVEAEKLRGRPLGAVGKYRVRRKFPLPRTIWDGEETSYCFKEKSRTVLREWYSHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKDRDHPGMGQGSLSQDPNSPGSDIKEEHSPDSLHGSGGHTKLEPNTPPPPSSHSQQHTQPPHPSAIYADLQKASNMAASVSAGSMMAAAAAAAAHGMMGGGGNMVGGGGGMGVGHPHHNTSHGGYHHHHQQQQQHQHHSNPHHNPHHNLHHHSLVGNPVGVGGDVGHMMQEYQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZL55</accession>
    <name>A0A3S0ZL55_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Rap guanine nucleotide exchange factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_022300</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RAPGEF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001531">
        <property type="protein sequence ID" value="RUS69937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S0ZL55"/>
    <dbReference type="OrthoDB" id="21144at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PDZ_RapGEF2_RapGEF6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
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    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
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    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
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    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF249">
        <property type="entry name" value="RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="6">
        <location>
            <begin position="260"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="9">
        <location>
            <begin position="391"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="515"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="8">
        <location>
            <begin position="744"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="5">
        <location>
            <begin position="855"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="142"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="608"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="678"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1118"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1175"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="608"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="644"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="697"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1136"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1200"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1234"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1269"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS69937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1326" mass="148751" checksum="BA3386EB093D5FFA" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZMH6</accession>
    <name>A0A3S0ZMH6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_011079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000352">
        <property type="protein sequence ID" value="RUS81171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZMH6"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS81171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="259" mass="28042" checksum="8E578657F75EAF54" modified="2019-04-10" version="1">MAPLASRQSAPMMLCPSSPSLKPLSFSLQSYRGGGCAIFLHPLTSPVIAATKEASQNSVPATGGGGRGFHARKTRTETLGRQSRGRIKDLGGIACAVILGLFNVWFWNEDRRWPRLCHQAPAHVGSRDRLCDGAGPGLDRMMTAAHGMTSFRHLQDMTCGTKASEGQTQPNSEVRVWRGRARSCTVQTTVRVLETRVAWPGPDCHVMKDRQGRGQSRLATLGQSTKDAGLCAGPVSRVSSSGPIRRIQANRLQAERLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZQC6</accession>
    <name>A0A3S0ZQC6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_007878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000208">
        <property type="protein sequence ID" value="RUS84346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZQC6"/>
    <dbReference type="STRING" id="188477.A0A3S0ZQC6"/>
    <dbReference type="OrthoDB" id="10070186at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS84346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="209" mass="22852" checksum="A76922731A5311DB" modified="2019-04-10" version="1">MRTRAVRGHSQVTEGLRGLGGVQRSQGQRKAEQMRSHVAILKQLPTQAATQVVKTEAQTLKKLNQIGLRGGGDKPSTLGFSNELDSVSILKPTQQIDCVSNIPTTSHFCLFGSRMPSVIASERMPSVIVSERMPSVIVSERMPSVIVSERMPSVIVSERMPSVIVSERMPSVIVSERMPSVIVSERMPSVIVSERMPSVIVSETHTATY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZQI1</accession>
    <name>A0A3S0ZQI1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_007812</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000206">
        <property type="protein sequence ID" value="RUS84428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZQI1"/>
    <dbReference type="STRING" id="188477.A0A3S0ZQI1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS84428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="198" mass="21251" checksum="F390CE5BE9735153" modified="2019-04-10" version="1" fragment="single">LAHSADKQCKHNTVKSIIECSTALPLAHSADKQCKHNTVKSIIECSTALPLAHSADKQCKHNTVKSIIECSTALPLAHTSDKQCKHSTVKSIIECSTALPLAHSADKQCKHNTVKSIIECSTALPLAHSADKQCKHNTVKSIIECSTVLPLAHSSDKQCKHSTVKSIIECSTALPLAHSADKQCKHSTVKSIIEHSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZSX9</accession>
    <name>A0A3S0ZSX9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytoplasmic tRNA 2-thiolation protein 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_006251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000154">
        <property type="protein sequence ID" value="RUS85981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZSX9"/>
    <dbReference type="STRING" id="188477.A0A3S0ZSX9"/>
    <dbReference type="OrthoDB" id="198857at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032442">
        <property type="entry name" value="CTU1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16503">
        <property type="entry name" value="zn-ribbon_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018556244" description="Cytoplasmic tRNA 2-thiolation protein 1 C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Cytoplasmic tRNA 2-thiolation protein 1 C-terminal" evidence="2">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS85981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="124" mass="13198" checksum="20B0FC5B9406DD71" modified="2019-04-10" version="1">MSSFNMNLCCVHFSAAVCSVCQFVSSNEVCKACVLLEGLNKGRPRLGIGKIHKERRKWEEDLAAEVGRLSVQGAVADDVGGDAGRGGCCGGTGKGGCGKTQRDSRITTERSSIPKTTMRNLLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZUE8</accession>
    <name>A0A3S0ZUE8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Neutral metalloproteinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_005275</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000123">
        <property type="protein sequence ID" value="RUS86950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZUE8"/>
    <dbReference type="STRING" id="188477.A0A3S0ZUE8"/>
    <dbReference type="OrthoDB" id="5332336at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023612">
        <property type="entry name" value="Peptidase_M4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001570">
        <property type="entry name" value="Peptidase_M4_C_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013856">
        <property type="entry name" value="Peptidase_M4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050728">
        <property type="entry name" value="Zinc_Metalloprotease_M4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33794">
        <property type="entry name" value="BACILLOLYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33794:SF1">
        <property type="entry name" value="BACILLOLYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01447">
        <property type="entry name" value="Peptidase_M4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02868">
        <property type="entry name" value="Peptidase_M4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00730">
        <property type="entry name" value="THERMOLYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018730483" description="Neutral metalloproteinase" evidence="7">
        <location>
            <begin position="17"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M4" evidence="8">
        <location>
            <begin position="236"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M4 C-terminal" evidence="9">
        <location>
            <begin position="370"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS86950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="57927" checksum="9A768247CCC7C586" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZUZ2</accession>
    <name>A0A3S0ZUZ2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Receptor-binding cancer antigen expressed on SiSo cells</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_005727</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000137">
        <property type="protein sequence ID" value="RUS86477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZUZ2"/>
    <dbReference type="STRING" id="188477.A0A3S0ZUZ2"/>
    <dbReference type="OrthoDB" id="10017216at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030141">
        <property type="term" value="C:secretory granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017025">
        <property type="entry name" value="Cancer-assoc_antigen_RCAS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15208:SF2">
        <property type="entry name" value="RECEPTOR-BINDING CANCER ANTIGEN EXPRESSED ON SISO CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15208">
        <property type="entry name" value="RECEPTOR-BINDING CANCER ANTIGEN EXPRESSED ON SISO CELLS CANCER ASSOCIATED SURFACE ANTIGEN RCAS1 ESTROGEN RECEPTOR-BINDING FRAGMENT- ASSOCIATED GENE 9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS86477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="27703" checksum="79AF52ACEA24E06F" modified="2019-04-10" version="1" fragment="single">MLQVVWNIIKYIYGLFYAIVRPLRRVVCRRRKLSTSDDIALTSVGTGNLRLSTPQQYGDDQNADLEMESWDAWDNSTDGGDAYKNGYHGKPSLGVSSIQNYHYNQQRQQQQQEQQQVEPEPDFFGDMTPTVKKQTKILIRKKEEEIPAGRSISSRLAVMSDVPMVTSELEAWEEEEARSAWDSEEVCEDLTWQAEEAIRETRRKERAQRVAQNQRRKQQRDQERARTNSGGGGGGGVAMATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZV87</accession>
    <name>A0A3S0ZV87_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_016152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000688">
        <property type="protein sequence ID" value="RUS76078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZV87"/>
    <dbReference type="OrthoDB" id="5965452at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS76078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="440" mass="47852" checksum="63037F69FC7B8446" modified="2019-04-10" version="1">MACDTACVGTSPHVWSSSGDTAPSPRILGASQSRSKLPANSVPFVGDEAKSLQLGSQNVNNICADNWNEHHLESMRTIDGSRCHLGTSENISVLQRGLREDVSNIRRQFGYFDTNDRKSRAEESENTAFPQSGFPESVAQSKELDDHYTIPKILLEPPPSPSTETIRGTTVDDLPTVPRQTGYLSTHYLYSDYCLGQHDLMTSNDSGSCVPSTECCVELPCRYQQRLQQDLENSNVVLDETNGSDVSRDDKDQREADLGTALKWIRQEICNVSAWERSIGISVWRDQNLSDLEMKEQDKSLLKQFIELRASILQLRCLCDPDLQGSCSDVSSVGSGSTYSLNEPATAAGGGGMTYSSSISNNINRIHINSSSNCSVLKSPHQLRRMLLKGGSDFGTVSGRGAGASLGSRGTGGPGGGVVSLSLPNSPRVARLRWRSDQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZZL3</accession>
    <name>A0A3S0ZZL3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_001640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000028">
        <property type="protein sequence ID" value="RUS90643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZZL3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS90643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="274" mass="29979" checksum="5729579AB7AF7C0F" modified="2019-04-10" version="1">MYYYIPLTLSGKSADERKDNGRSVSRTSLEFPRNSGNWEHSVRTVSDPRPRVSQYRPTTKEIPRSLRFPTSKGKSDQRISKIKTNFPNQPKRTSTSSGYYVDGGTSRKVYIVGPNLGGAKTIQGDGYRPSPNSSTIRISSGIRVLNHPLACPCIGLARSRCGCGHQGEAPRATNKCLSVITPPSGYDMEQPLTVTSTRSARFPPGGPRGTSGSGARADTHGEAEEWKGRGIKLPARRRTSKEDQQGKKVPFPSDPRNNCGVVFQLRTSPLGYSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A2J5</accession>
    <name>A0A3S1A2J5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_000074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000001">
        <property type="protein sequence ID" value="RUS92221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A2J5"/>
    <dbReference type="OrthoDB" id="432483at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS92221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="480" mass="51475" checksum="CDD1B505FE614871" modified="2019-04-10" version="1">MDGLSSRRSSRLRRSLKSTPCLTALRTESQESEADIPVIDTAVEDGPDLSLFRTSRLQGRPSREEATLDTVEYPSDEDVRESGAGILEFTPAKAGLDMTPANYDFETRDDKKRNATGLSNFAAGALSSVSNTLMHVVSKGYEGNKRSQETAPLLQDQNASPEAHAKTTPVSSVPKSTSSVTLPVSSTSSYYSQYEDQHGGYGVGGHTSMVATVHPFSQSEVPQTIPSSPLQVERRLNELSKQLTRLEHKMSSDIALILHVLQAQGSSSQVTSPSTPPPPPPRMVEADTFPGSSGEYSNVYNYPPPPSHLPPPPSSEALSTIDSDLTWLPHESSQDPSSPPPYPASSYHSATHTSPRAMSPVSPLRAPAVPPQPGHVPPISSCPPITSHQLPADSQTQTISQREGQPSNVTPSVPSQDPVDMVGFAQRDEHLGLSNNQSVYQSQYEPMILSSGEGDSLLQAEQGTYRGQSGDPDDVSDTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A313</accession>
    <name>A0A3S1A313_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_010816</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000338">
        <property type="protein sequence ID" value="RUS81432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S1A313"/>
    <dbReference type="OrthoDB" id="6288751at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042378">
        <property type="entry name" value="IDD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15256">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN DGCR2/IDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15256:SF6">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN DGCR2_IDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018643869" description="VWFC domain-containing protein" evidence="3">
        <location>
            <begin position="27"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="4">
        <location>
            <begin position="56"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="674"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="824"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="959"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1093"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1273"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="478"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="825"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="859"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1119"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1376"/>
            <end position="1388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS81432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1388" mass="150196" checksum="FD2E29477300DA8B" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A4H6</accession>
    <name>A0A3S1A4H6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_009710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000282">
        <property type="protein sequence ID" value="RUS82538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A4H6"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS82538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="13018" checksum="D9EBEECFCDDB8AB3" modified="2019-04-10" version="1" fragment="single">IVNFLKLFIVNCLLLIAYCLLPIAYCLLLIAYSLVLIAYSILLIAIAYCLQPIAHCYCLLLIAYCLLLIAYCVLLLAYCLLLIARCLLFIAYCLLLIAYCLLLIAYCLLPIALCLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A4K9</accession>
    <name>A0A3S1A4K9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_001737</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="RQTK01000031">
        <property type="protein sequence ID" value="RUS90469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A4K9"/>
    <dbReference type="STRING" id="188477.A0A3S1A4K9"/>
    <dbReference type="OrthoDB" id="4983at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042281">
        <property type="term" value="F:dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF1">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="457"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="457"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="475"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS90469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="488" mass="54864" checksum="EA40E8760C9FC416" modified="2019-04-10" version="1">MHGDFEAQRHWMELTSNLPAKQWYVQGPKNDLQYWGLDYPPLTAYHMMAAGMIAKKINPDLVELGTSQGIETPDVKFFMRSSVLIMDILLFLPAAIAYFIYSRSQNTDESIILNSILVIAAYPGLILIDNGHFQYNNVSLGLVVLATLALHLRSDVLAAMLFCLSLNYKQMELYHALPFFAYLLGRCIKSGLFKGVYKLASLGFVVIGTFAIIWSPFLSSVESAKAVILRLFPFNRGLYEDKVANFWCSISPLIKFKDIVVPQDMAKICMLVTGLLALPSFIALLREPTIKKFHYGIINISLVFFLFSFHVHEKSILIAAIPACLVIDKDPLAVVWFLLISVFSMVPLLMKDGLLIPTAVAVSIFWMSSNHFVRPSMNHPIQVVYAMHLSLLGAVCLILATRFIPPPQRFPDLFHLLIAIYSCAHFFTFAVYFHLRQFGGLYEQVLWNVLEGSEGNVSQRKSAGQGSGSQHKNLSSGRSSSRPPRQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AFP7</accession>
    <name>A0A3S1AFP7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein phosphatase</fullName>
            <ecNumber evidence="10">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_001585</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="10"/>
    <dbReference type="EMBL" id="RQTK01000027">
        <property type="protein sequence ID" value="RUS90685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AFP7"/>
    <dbReference type="STRING" id="188477.A0A3S1AFP7"/>
    <dbReference type="OrthoDB" id="60843at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000009">
        <property type="entry name" value="Blast:Protein phosphatase PTC7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE PTC7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13672">
        <property type="entry name" value="PP2C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 10" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="11">
        <location>
            <begin position="46"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS90685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="309" mass="34024" checksum="7203A54B6C2CAB92" modified="2019-04-10" version="1">MQSVAQYGRIVARAIAAGIHNEFQLKSPYDKPKEPLHFVSGVSGFSKSLSKSNHTKWTFGDDAYFISRNKVADVIGVADGVGGWRSYGIDPSTFPRTLMLACERMVRDGHFVPQSPANIIAAGYSEMLEQKVPTLGSSTACVVSLHREERTIYSANLGDSGFLVVRDGEIVHRSTEQQHYFNAPYQLTVPPPSIDTQWLSDSPDMAESSSFKVQDGDVLMLATDGLFDNLSEDMIVRSLVALHDHKDEERVQHAARNMADYAYQLSLDPDYMSPFALSACDIGINLSGGKPDDITCIVARVTHQSDIFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AU65</accession>
    <name>A0A3S1AU65_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Neurotransmitter-gated ion-channel ligand-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_020049</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001100">
        <property type="protein sequence ID" value="RUS72184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AU65"/>
    <dbReference type="STRING" id="188477.A0A3S1AU65"/>
    <dbReference type="OrthoDB" id="407674at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="12">
        <location>
            <begin position="34"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="13">
        <location>
            <begin position="257"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS72184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="48567" checksum="ABB664243AE2021B" modified="2019-04-10" version="1">MKGTTLYSSSIPIFVSALLFHIARTQSSRSPRQDILRGLLNGTGLLYDARVPPNFEENVATDVSVQIYVMSFDSLTEISMEYRLSIFLRMNWTDPRLVWNNSDIHGPLEVDPKLVGMIWAPDLYFLNEKEAIIHDVTVMNNLMHIYEDGTIHTSTRISMTLSCDMHLERYPHDEQTCSIFAGSYSYSKENVILQWHRYPLQMRPTLTLPRFTVMGHNTIDCEIVDYGEQSMINAGNFSCIQANFFLRRQFGYYIAQVYIPSILIVVLSWVSFWIDIDAIPARVSLGLLTVLAITTQSTGEKSGLPRVSYIKAIDLWMAVCLMFVFMALLEFSYVNVQCRVQKRRQETILIEASTNTDEPRNGKERNDLDLQPRSGRRFVFFRDRMKVQRARFVDKCARVVFPLLFFLFNICYWLYYQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AYF9</accession>
    <name>A0A3S1AYF9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_020691</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001198">
        <property type="protein sequence ID" value="RUS71551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AYF9"/>
    <dbReference type="OrthoDB" id="6162106at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050801">
        <property type="entry name" value="Ca-Dep_Lectins_ImmuneDev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801:SF63">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801">
        <property type="entry name" value="LITHOSTATHINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018644068" description="C-type lectin domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="49"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS71551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="235" mass="26604" checksum="C63612769946878A" modified="2019-04-10" version="1">MQSTLGTRNMFFAAITLLFLISVAAESTLQNSCPTEVLKKVNAFYLQVHDGICFHFVTNEKRTHSDASRECRHYDGLLAMPKTKSINDFLTTKATTVYGVSDPMWIGLHDRINEKEFVWEDNTKLVWGNFKKGNGPGNNIFQGSFEDCVVIHPSDGGLWGDDQCERDIISIISGSKPKKKYICQYTLDIVNNTVNDAIKNKDPKVKDQQDVDQQDTDQQAVDQQDVDQQDTDQQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AYL4</accession>
    <name>A0A3S1AYL4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB/POZ domain-containing protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_021666</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001380">
        <property type="protein sequence ID" value="RUS70567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AYL4"/>
    <dbReference type="STRING" id="188477.A0A3S1AYL4"/>
    <dbReference type="OrthoDB" id="9997739at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008344">
        <property type="term" value="P:adult locomotory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048512">
        <property type="term" value="P:circadian behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050804">
        <property type="term" value="P:modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14822">
        <property type="entry name" value="BACK_BTBD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18287">
        <property type="entry name" value="BTB_POZ_BTBD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000005">
        <property type="entry name" value="BTB/POZ domain-containing protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000038">
        <property type="entry name" value="BTB/POZ domain-containing protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000051">
        <property type="entry name" value="BTB/POZ domain-containing protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000042">
        <property type="entry name" value="BTB/POZ domain-containing protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052407">
        <property type="entry name" value="BTB_POZ_domain_cont_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034091">
        <property type="entry name" value="BTBD9_BACK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46306">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46306:SF1">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="36"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="588"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="624"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS70567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="661" mass="72958" checksum="7FC391715DC9AEBA" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B0R3</accession>
    <name>A0A3S1B0R3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_023159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001843">
        <property type="protein sequence ID" value="RUS69079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B0R3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS69079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="121" mass="12980" checksum="3447FB138B9023D8" modified="2019-04-10" version="1">MYLCPQIYNYRPQSVEFIFCTQNANPRLCVDSLSNPAAHSYLQVYIQPHIRSLSHTHKDIPPGEKLCYASSDSSSSPPSSSSSCFLLTPRTSPSSPSASSSSSSSSSSPSSSSSAREGRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B172</accession>
    <name>A0A3S1B172_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6451 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_014821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000582">
        <property type="protein sequence ID" value="RUS77418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B172"/>
    <dbReference type="STRING" id="188477.A0A3S1B172"/>
    <dbReference type="OrthoDB" id="6142715at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045609">
        <property type="entry name" value="DUF6451"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF25">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20049">
        <property type="entry name" value="DUF6451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6451" evidence="1">
        <location>
            <begin position="282"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS77418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="484" mass="54735" checksum="6955D34007E0F261" modified="2019-04-10" version="1">MTQASESLREASLPTVLLTTKTKTRIGTWNILTLYETGRIAQVSKEMKEYSMKIMGLCETRWTEADRRTLVGGETIIYSGHEDGHVRVHEHEVGMIIAPDTVGASIAWEPVSPRILTARFTSKGRTFTIIQCYSPTNAAKDQEKEEFYEKLQATFNKAPRRDMKIVMGDINAKVGMENAAKQRERWAEHFKEILLDYHPLSPPDASETLEGNMKPPTNAEIRKAIKTMKSGKAAGPDGIPSEALKDDINTSTDMLQRFLLSVVDKHGGTEEDIKSRTNKARFTFNRPIWNSSALSIRNKSRIFNANVKSVLLYGELFVEFCSFNDLAIGQKHILPGKRQRRKTITCAAKQRERWAEHLKEILLDYHPLSPPDASETLEGNMKPPTKAEIRKAIKTMKSGKAAGPDGIPSEALKDDINTSTNMLQRFLQKVWGWIGHTLRKRPTDITRQSLEWNPQGKRKVGQPKQTWRRNMRQRLGVLAGDGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B3L5</accession>
    <name>A0A3S1B3L5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_021070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001261">
        <property type="protein sequence ID" value="RUS71170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B3L5"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS71170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="135" mass="15992" checksum="60C7E2EE145AE7E7" modified="2019-04-10" version="1">MQHYLPKHHQTVVPFKHQTARFVHLHSRKRRRLTPLNLLRKRDLVLSVRLFLLTLLALLVVTSIMLCAWNTDKFSVMETSLDVRIRLRRYHLLAYNSRSADTNFSLKHDLGLYFSKFLGQIRGQIFHTAKRRGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B8E0</accession>
    <name>A0A3S1B8E0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metallo-beta-lactamase domain-containing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Endoribonuclease MBLAC1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_014711</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Endoribonuclease that catalyzes the hydrolysis of histone-coding pre-mRNA 3'-end. Involved in histone pre-mRNA processing during the S-phase of the cell cycle, which is required for entering/progressing through S-phase. Cleaves histone pre-mRNA at a major and a minor cleavage site after the 5'-ACCCA-3' and the 5'-ACCCACA-3' sequence, respectively, and located downstream of the stem-loop. May require the presence of the HDE element located at the histone pre-RNA 3'-end to avoid non-specific cleavage.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a ribonucleotidyl-ribonucleotide-RNA + H2O = a 3'-end ribonucleotide-RNA + a 5'-end 5'-phospho-ribonucleoside-RNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68096"/>
            <dbReference type="Rhea" id="RHEA-COMP:15179"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="Rhea" id="RHEA-COMP:17428"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:74896"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:68097"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000574">
        <property type="protein sequence ID" value="RUS77527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B8E0"/>
    <dbReference type="STRING" id="188477.A0A3S1B8E0"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd07711">
        <property type="entry name" value="MBLAC1-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039344">
        <property type="entry name" value="MBLAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23200">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23200:SF48">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="7">
        <location>
            <begin position="4"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS77527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="211" mass="24004" checksum="18717ECE082E6EF3" modified="2019-04-10" version="1">MRASGSVTLLKGPQKNILVDAGSPWDKDEIIRGLMRQNVRPEDINYMVCTHGHPDHVGNINLFTKAVLIMGFNIQFEDRYFLHDFKQGIPYEIDEEVEVWPTPGHTSEDVSVVVKHTNLGTVVVAGDLFECEADLDCPSLWQEMSHQPHQQEQSRIEVLKMANFIVPGHGPMFQVPEHMKSQMKVIMVVEEQFYSPHMTSSVTECIITETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B8G7</accession>
    <name>A0A3S1B8G7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_009881</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000289">
        <property type="protein sequence ID" value="RUS82366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B8G7"/>
    <dbReference type="STRING" id="188477.A0A3S1B8G7"/>
    <dbReference type="OrthoDB" id="10012075at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032589">
        <property type="term" value="C:neuron projection membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF36">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 9, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="78"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="183"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS82366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="334" mass="36956" checksum="16C067448A15C65D" modified="2019-04-10" version="1">MDSDACYFFLRHRRRRMGGTIPDHLMLHTLNVGSPASRGTPGISWTRSLELVLCILLLLMILPAASHVDWRTRVPVDPVFLKTNSNITVREGGRAELPCTVQHLGTKQVVWRHVDADKYLTIAQQPWSPDVDVEVHHVQHNEELSDWTLVLPKVKKVDAGLYQCQLTSSAGFHTFVRLNVVGPPITEPDVVLKGTQFVERGGKIELQCNATGGKQLADAIDWFKDGNIITGERLKEYKILSTHMLEHGALVSNLQIDRARIQNGGTYVCRSSHNVLRDIVVQVLVADSSNKKRGTISSANSSNSSRSGAMETSSSPSPLCLLVGLLVYVWPLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B9L2</accession>
    <name>A0A3S1B9L2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dolichyldiphosphatase</fullName>
            <ecNumber evidence="11">3.6.1.43</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_013136</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>a di-trans,poly-cis-dolichyl diphosphate + H2O = a di-trans,poly-cis-dolichyl phosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14385"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="EC" id="3.6.1.43"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the dolichyldiphosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.43" evidence="11"/>
    <dbReference type="EMBL" id="RQTK01000471">
        <property type="protein sequence ID" value="RUS79083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B9L2"/>
    <dbReference type="STRING" id="188477.A0A3S1B9L2"/>
    <dbReference type="OrthoDB" id="302705at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047874">
        <property type="term" value="F:dolichyldiphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03382">
        <property type="entry name" value="PAP2_dolichyldiphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000003">
        <property type="entry name" value="Dolichyldiphosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039667">
        <property type="entry name" value="Dolichyldiphosphatase_PAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF1">
        <property type="entry name" value="DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="12">
        <location>
            <begin position="64"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS79083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="241" mass="27746" checksum="AE57E32667C7CBBB" modified="2019-04-10" version="1">MAEDVVKMNSQELDTLDWKAVSFTYVEYPKGDFLGYILAWVSLLPMIILVSFATLIIFRRDLHTIAFATGLVVNEAVNWIVKHAVKEARPMRGRQNLNTEYGMPSSHSQFMWFFSSYFAVFLLLRLYRNHSIIDDLWKYVCALLGILAAILVSWSRVYLMYHTVGQVAVGAVLGIFLSAPWFCFVHFLLTPVFPILSSSPLGELLMLRDSTLIPHVLWFEYTCSRSEARSRQRKMSSRKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-05-03" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BCL2</accession>
    <name>A0A3S1BCL2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_011384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000369">
        <property type="protein sequence ID" value="RUS80865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BCL2"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS80865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="108" mass="12458" checksum="E5AE2A795904BC08" modified="2019-04-10" version="1">MHRYFPPSHLAFCVFGYICHTPQTASHDAFTNGHPPIFHTAFTPLCIHYSMTTRFPPSIDYGDSPYSTRCPPWCYSPYSILYPAWSDSPYSTFYPPDYQQSPVKPQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BE37</accession>
    <name>A0A3S1BE37_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_013539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000495">
        <property type="protein sequence ID" value="RUS78684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BE37"/>
    <dbReference type="STRING" id="188477.A0A3S1BE37"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35151">
        <property type="entry name" value="ELONGATION FACTOR 1 BETA CENTRAL ACIDIC REGION EUKARYOTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35151:SF2">
        <property type="entry name" value="ELONGATION FACTOR 1 BETA CENTRAL ACIDIC REGION EUKARYOTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS78684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="243" mass="26527" checksum="DDF70A08A67D82F3" modified="2019-04-10" version="1">MVTVDKVEVVTVDKVQAVTVDKVNMVTVDKVEMVTVDKVDVVTVNKVEVVTVDKVDVVTVNKVEVVTVDKVNMVTVDKVEMVTVDKVDVVTVDKVDVVTVNKVEVVTVDKVDVVTVNKVEVVTVDKVEVVTVNKVEVVTVDKVEMVTVDKVEVVTVDKVEMVTVDKVEMVTVDKVEVVTVDKVEMVTVDKVEVVTVEEVEMVTVGRVEMVTVDKVGMVSVDKVELVTLDKVEVVSVLVSGGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BFD5</accession>
    <name>A0A3S1BFD5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Pre-mRNA-splicing factor SLU7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_005189</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the SLU7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000121">
        <property type="protein sequence ID" value="RUS87036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BFD5"/>
    <dbReference type="STRING" id="188477.A0A3S1BFD5"/>
    <dbReference type="OrthoDB" id="249612at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030628">
        <property type="term" value="F:pre-mRNA 3'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021715">
        <property type="entry name" value="Slu7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039974">
        <property type="entry name" value="Splicing_factor_SLU7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942">
        <property type="entry name" value="STEP II SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11708">
        <property type="entry name" value="Slu7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor SLU7" evidence="11">
        <location>
            <begin position="164"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="463"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="464"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="483"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="506"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="535"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="551"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS87036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="603" mass="70165" checksum="3212ECAEB8F7F143" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BIY7</accession>
    <name>A0A3S1BIY7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleolar protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_007343</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000190">
        <property type="protein sequence ID" value="RUS84874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BIY7"/>
    <dbReference type="STRING" id="188477.A0A3S1BIY7"/>
    <dbReference type="OrthoDB" id="285729at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019002">
        <property type="entry name" value="Ribosome_biogenesis_Nop16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243">
        <property type="entry name" value="HSPC111 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09420">
        <property type="entry name" value="Nop16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS84874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="178" mass="20741" checksum="6E1C9314F09FC1F3" modified="2019-04-10" version="1">MGKVKKQKSHKKFDYNRDRKKNRKKSKAVPSIRCEEIKKAWDVTKSVKKNLEDMGIAADSNKAIKVPKSKPLAMGTLDVEMELDLEKTPIKKFVMDDLEARSKIPGKKKMSMSDEDAGFCVYMMDTYGENYKAMARDERNYYQETPKQIQRKINRFKSIPDMYKIYTEARQGESTMDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BM18</accession>
    <name>A0A3S1BM18_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_021993</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001452">
        <property type="protein sequence ID" value="RUS70248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S1BM18"/>
    <dbReference type="OrthoDB" id="10053569at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004502">
        <property type="term" value="F:kynurenine 3-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070189">
        <property type="term" value="P:kynurenine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028">
        <property type="entry name" value="KYNURENINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028:SF2">
        <property type="entry name" value="KYNURENINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="98"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="98"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="167"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS70248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="25870" checksum="87679E5F36912DD4" modified="2019-04-10" version="1">MMACYLAKRGYKVDIYERRTDIRLMEVVRGRSINLALSCRGREALRGVGLEAEISKNGIPMRARMIHDLNDQRRPIPYGTKDQYIMSIDRRLLNEVLLTEEEEEEEEEEEEEEEEEEEEEEEEDEEDEEEEEEEEEEEEEEEEEEEEEEXXXXXXXXXXXXXXXXXXKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKAMVMVMMMMIKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BNX1</accession>
    <name>A0A3S1BNX1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_004181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000094">
        <property type="protein sequence ID" value="RUS88015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BNX1"/>
    <dbReference type="OrthoDB" id="6099649at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015347">
        <property type="term" value="F:sodium-independent organic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043252">
        <property type="term" value="P:sodium-independent organic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388">
        <property type="entry name" value="ORGANIC ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388:SF100">
        <property type="entry name" value="SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 4A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS88015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="17243" checksum="CA4E734ECFCF7B9F" modified="2019-04-10" version="1">MCSYGCAHIYTYFAAITVRGLFGTLSIVPKLIVYIRCVTPKDKGLAIGFSAFMTSLLGWLLGPIIFGRVIDGICTVWDVTQTGNRGRCLLYDNDVFRLKLHGFSSAGLLGCTSFLLIGYVYARCTGCLDPPSIEVTVDGTQMKTRRGQKLRKGKENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BRN0</accession>
    <name>A0A3S1BRN0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Neurotransmitter-gated ion-channel transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_002319</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000045">
        <property type="protein sequence ID" value="RUS89878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BRN0"/>
    <dbReference type="STRING" id="188477.A0A3S1BRN0"/>
    <dbReference type="OrthoDB" id="6127156at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="3">
        <location>
            <begin position="70"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS89878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="269" mass="29812" checksum="AB5A5B1077C7070F" modified="2019-04-10" version="1">MCMNYAKSDLQFVAGSETAGAQFFTQNGQWDILNMTVSTRNERIGQEEKSTIVIGFDVKRKPTFLVLSVLLPIVFLSLLNLLVFVIPVDSGEKISYGITVLLALSVFMSIMSSMLPSSSESMPLMISYIFILMIISVLTVVDSIIIVGLHHMEEKEEKSQKVKAKFKTVLPKMSFFKKTVAPVQKLPSVPADFNNQNEAGFKSKHPNTENPDPTDKSSPPFPVVSRWGEEKPTVNNYKVIGKYIDTVSLAVFAVIWLSVTLGFMAAMTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BT79</accession>
    <name>A0A3S1BT79_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">EGW08_004069</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">EC2010</strain>
            <tissue evidence="23">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000091">
        <property type="protein sequence ID" value="RUS88172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S1BT79"/>
    <dbReference type="OrthoDB" id="424310at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001810">
        <property type="entry name" value="Cytoplasmic dynein 2 heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000153">
        <property type="entry name" value="Dynein axonemal heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000002">
        <property type="entry name" value="Dynein axonemal heavy chain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000005">
        <property type="entry name" value="Dynein axonemal heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000001">
        <property type="entry name" value="dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000001">
        <property type="entry name" value="dynein heavy chain 7, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000049">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF69">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Dynein heavy chain 3 AAA+ lid" evidence="20">
        <location>
            <begin position="11"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA module D4" evidence="18">
        <location>
            <begin position="186"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain coiled coil stalk" evidence="17">
        <location>
            <begin position="464"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain ATP-binding dynein motor region" evidence="19">
        <location>
            <begin position="824"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain region D6 P-loop" evidence="16">
        <location>
            <begin position="1415"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA lid" evidence="21">
        <location>
            <begin position="1569"/>
            <end position="1708"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain C-terminal" evidence="22">
        <location>
            <begin position="1717"/>
            <end position="2119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1256"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2050"/>
            <end position="2070"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="679"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF12780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF12781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF17857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF18198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF18199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="RUS88172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="25">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2123" mass="240090" checksum="6ECDF04F9934D7C1" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BUN9</accession>
    <name>A0A3S1BUN9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_000203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000003">
        <property type="protein sequence ID" value="RUS91990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BUN9"/>
    <dbReference type="STRING" id="188477.A0A3S1BUN9"/>
    <dbReference type="OrthoDB" id="10031946at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020339">
        <property type="entry name" value="C20orf85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31909">
        <property type="entry name" value="CHROMOSOME 20 ORF85 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31909:SF3">
        <property type="entry name" value="SIMILAR TO PROTEIN C20ORF85 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14945">
        <property type="entry name" value="LLC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS91990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="147" mass="16208" checksum="1CB350CFC35BBD1F" modified="2019-04-10" version="1">MAAAAGGSTKNQGQALAGCNFVAQDQIWKDHVGHEYAATKTWPANWNFLTTDYEELVREDFPNREPDKSKREAAKKAVKNLIEVPPVTPIDKYITVLPSTRPVPKTTAGQVGWRSTDRALALEKYGGYAKPKGGLVKQLNWPQEGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BUQ5</accession>
    <name>A0A3S1BUQ5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NXPE C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_000538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000007">
        <property type="protein sequence ID" value="RUS91712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BUQ5"/>
    <dbReference type="OrthoDB" id="6148740at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057106">
        <property type="entry name" value="NXPE4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16165">
        <property type="entry name" value="NXPE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16165:SF5">
        <property type="entry name" value="NXPE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24536">
        <property type="entry name" value="NXPE4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NXPE C-terminal" evidence="1">
        <location>
            <begin position="16"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS91712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="246" mass="28367" checksum="59BBBC9C3AD42988" modified="2019-04-10" version="1" fragment="single">TWQLQRPRGFMLHGHWIRTDCATGRLDAGVERACLANTTLTFAGDSTLLQLFTDLIPRTGCTLVESHALHWHRPRACVRADTGFQMSWALHGHPHQNQQQQQHQHQQPLLLQQQQQFEHLPQKQRHVVLITLFIHLSIHHMNVFRDRIRAARMAVERLLERSPSTLVVVRGPHTAYYGWSPHLGGDMMGPAMREIIVSEFRPLRDKVVYLDFWDMTVAMENSNFHPDPAINTAMLNALLHHVCAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BVZ2</accession>
    <name>A0A3S1BVZ2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lipase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_002139</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000040">
        <property type="protein sequence ID" value="RUS90097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BVZ2"/>
    <dbReference type="STRING" id="188477.A0A3S1BVZ2"/>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000021">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025483">
        <property type="entry name" value="Lipase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000862">
        <property type="entry name" value="Steryl_ester_lip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="9">
        <location>
            <begin position="7"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000862-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS90097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="375" mass="42205" checksum="DFAD73EC5F018B4E" modified="2019-04-10" version="1">MFPAQTKLITSKGYPCENYWVTTDDGYILNLQRIPHGRNTDTLKKPRPAVLLQHGLLLSSTIFMLNSARDSLAFLLADQGLDVWLANSRGNIYSTNHTAMDPNSNEFWDFSWDEMARYDLPAMIDFITMETGQAKISYVGYSQGTTIGFAALSQNARVAAKVRLFIALAPVGRVGNITSVVRLLLPLTSKVKTIMKLFPHGNFDLDPDVSRSMAGYFCHNRRDLLCEKLFSLLVGSNPRSFDMTRLDVYMAHMPAGTSVRNLMHWAQVTNGGRFQHYDWGSPRANLRKYGQPIPPQYELGQVMTPVAIFRGGQDALADTEDVNWLLAQLPNVAMDVALDYYNHMDFVAAPDAPEKIYWRIAALLTQSDLDLVDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C244</accession>
    <name>A0A3S1C244_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_011438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000372">
        <property type="protein sequence ID" value="RUS80817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C244"/>
    <dbReference type="OrthoDB" id="10484330at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS80817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="272" mass="29891" checksum="28DA5239C0B978FD" modified="2019-04-10" version="1">MWEPIAQVSTVAADGNTCKLTDSKQGLDAADHQYLGATNKTTGTDIVPSPEDPAVRKRHYRRPKTASVITLSIPLQKHLTKSEFRASSGPTSRSLSSTHSAKSPTLGKQPKYFDSRCNGTSFKSHQNRVNQKRSLDVPKIYLNSQDSSISADRHTLRSNSPPPQRFSEISFLKILLDTLPMERNDSLDSTENLSAEGVDGEEDIFGEITPVSSRGARKISTASLGCLRESLKTSRGYGKAGGNERMQRSRSASQMMTTAASVEKLLFRNRLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H251</accession>
    <name>A0A3S1H251_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_021545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001353">
        <property type="protein sequence ID" value="RUS70687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H251"/>
    <dbReference type="OrthoDB" id="10677476at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS70687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="296" mass="32276" checksum="DCE5C9F264142742" modified="2019-04-10" version="1">MGWVSGQSLTFALSARARPTFPLISPGLCPEAKFQKKSDPTSPTNSTEPSSAGGADKGDISKGAITALCIAGVLLVLLIVSAILFCVCYRRKMNKEHTRQSVGVQTHRRPLRSASFQRLARISQNLFRNPRNPRNPRNPQIPPQLEAVTTAEADCTSEPIYYEISNSDYEEPVVIQQAGPEVDAGLDKGQGYRYQRLRLVSPGRVSDTEESLLKTYGKDSATAERANPPDLLPAGELTQRTRDLGPEVLAVPQRRGEGEGQACGGEPEVSSPVADRPQPKPKPRSRTSQSTFKIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H2X7</accession>
    <name>A0A3S1H2X7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipid scramblase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_021062</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phospholipid scramblase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001260">
        <property type="protein sequence ID" value="RUS71175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H2X7"/>
    <dbReference type="OrthoDB" id="191150at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017128">
        <property type="term" value="F:phospholipid scramblase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005552">
        <property type="entry name" value="Scramblase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248:SF9">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03803">
        <property type="entry name" value="Scramblase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS71175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="314" mass="34985" checksum="57175B2E9625CB7B" modified="2019-04-10" version="1" fragment="single">TQNSAHIDRTVYINFVQCRLIVCAEKYSQRLQARPPSLMLTHTMYSLEKQPVTKQPTGGMSSVTKVTPAPRAATYPAGFPHDLDVCNSAVISQPGGLEALDGHSMLYVVQQVELLEAISGFETANKYEIQNRLGQKILIAAETSSCCFRRCCGSNRPFTIEITDLYGSTFMYIDRPLRCSQIPWCCCLQKLTVESPRGRPIGYVLQECSFIRPVFRVESGDHDDLFRIKGPWCMCKCCGSVKFKIKSPDGQANVGIISKDWAGLMQEMLTDADKFGVTFPESLAAEKKATLLAAVFLIDFLYFEDNSAKKKATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HAN6</accession>
    <name>A0A3S1HAN6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC-type glutathione-S-conjugate transporter</fullName>
            <ecNumber evidence="11">7.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EGW08_016746</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">EC2010</strain>
            <tissue evidence="16">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>leukotriene C4(in) + ATP + H2O = leukotriene C4(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38963"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57973"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:38964"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.3" evidence="11"/>
    <dbReference type="EMBL" id="RQTK01000737">
        <property type="protein sequence ID" value="RUS75497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HAN6"/>
    <dbReference type="STRING" id="188477.A0A3S1HAN6"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015431">
        <property type="term" value="F:ABC-type glutathione S-conjugate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18595">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18603">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000020">
        <property type="entry name" value="ABC metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000293">
        <property type="entry name" value="ATP binding cassette subfamily C member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000001">
        <property type="entry name" value="ATP-binding cassette subfamily C member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000074">
        <property type="entry name" value="Multidrug resistance-associated protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="610"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="658"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="742"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="1"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="295"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="613"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="936"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RUS75497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1175" mass="130701" checksum="6193627CAC65F8E2" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HBW9</accession>
    <name>A0A3S1HBW9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_016040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000681">
        <property type="protein sequence ID" value="RUS76196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HBW9"/>
    <dbReference type="STRING" id="188477.A0A3S1HBW9"/>
    <dbReference type="OrthoDB" id="6057617at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052065">
        <property type="entry name" value="Compl_asym_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906:SF43">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="6">
        <location>
            <begin position="858"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS76196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="952" mass="108146" checksum="480FF55B2E5D1C02" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HDU3</accession>
    <name>A0A3S1HDU3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_014882</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000586">
        <property type="protein sequence ID" value="RUS77368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HDU3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS77368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="204" mass="22798" checksum="F5AE8372E8EA6C8D" modified="2019-04-10" version="1">MISDFENNPKPSKFHSATLSKTDALWGTLSTEPLSTVVCVCVLVCDNSSVSSQADQQILSPHVVVIRRSLSGMTVPMLMTLECHLIHYREFPGTGETVRCDATRPPHGPLTAPSRPAVTRERFHMGRGDTSGWTMDAGCPLVARQRAHNLCAHNWHWLSPCQRLPVVHWERTCRQRKVVGFIYPPNSVDSSRSLYATAECLFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SIV1</accession>
    <name>A0A433SIV1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Translation initiation factor IF-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_023333</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IF-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001933">
        <property type="protein sequence ID" value="RUS68910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SIV1"/>
    <dbReference type="STRING" id="188477.A0A433SIV1"/>
    <dbReference type="OrthoDB" id="21573at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.110.10:FF:000001">
        <property type="entry name" value="Translation initiation factor IF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="entry name" value="Translation initiation factor 3 (IF-3), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036787">
        <property type="entry name" value="T_IF-3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019813">
        <property type="entry name" value="Translation_initiation_fac3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019815">
        <property type="entry name" value="Translation_initiation_fac_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019814">
        <property type="entry name" value="Translation_initiation_fac_3_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00168">
        <property type="entry name" value="infC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938:SF0">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00707">
        <property type="entry name" value="IF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05198">
        <property type="entry name" value="IF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="Translation initiation factor IF3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54364">
        <property type="entry name" value="Translation initiation factor IF3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00938">
        <property type="entry name" value="IF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor 3 N-terminal" evidence="5">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Translation initiation factor 3 C-terminal" evidence="4">
        <location>
            <begin position="91"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS68910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="20715" checksum="8DFD5FB329BE5376" modified="2019-05-08" version="1">MVEQCFEVYQDFGFNDFEVKIALRPENRIGSDDVWDKSEEMLKNALTNQGVEYSLLPATAKPPVCRLMDYGKFLFEQGKKKALARKNQKQTQVKEVKLRPVTDVGDYQVKLRNLIKFLEKGDKVKVTLRFRGREMSHKELGMQMLQRMANDALEYGIVEHQPKMEGRQMIMVLGPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SJV5</accession>
    <name>A0A433SJV5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_022862</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001705">
        <property type="protein sequence ID" value="RUS69376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SJV5"/>
    <dbReference type="STRING" id="188477.A0A433SJV5"/>
    <dbReference type="OrthoDB" id="3666223at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF6">
        <property type="entry name" value="CONTACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="100"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="207"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="326"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS69376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="409" mass="46055" checksum="4B7B4D904E754FBF" modified="2019-05-08" version="1" fragment="single">GQLKWSSDNSDIQTDFFPSRAVRNQQEELRGLNIVHDRIVYEYVDTGSNRSFAWGWDRIMSPGGFICQIPKADTWKIFQQRRDYSYGTATKDSSQWNMGPNITVYSQDTLFFELEENVVTPFVLDCQAVGNPRPTYKWYRQADMESPRVEVSSALGSNYAITNGRLKITNPSEAEDAGLYTCEASNSIGTVQSNPIQVSYRFLAEFPTLDVAPTDAILFRGVEISCQSIEAKADIAYNWFKREIGLVAVRPEFNSQYFISKNGKLYISEVQQSDQAAYHCVASMISKQGEKLASDQTPSRISKPIKLNVLGGSANTYGPDIQDKFPQFFPSVPEVGDRVEIECLAYGRMPIRYSWKREDGGDMNPQVQFEDHNRRLVIPSARLEDTGVYSCIANGPQGTVSKTAYLSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SLJ8</accession>
    <name>A0A433SLJ8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_022230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001513">
        <property type="protein sequence ID" value="RUS70013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SLJ8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS70013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="123" mass="13257" checksum="2C42F76B91C9B312" modified="2019-05-08" version="1" fragment="single">MQTMGSVTSMTCGASWYLPPEWARPSISVTIFSRVGTFSFSWSITSGAKLVVTDVVEERGEHGQQNHVHVVQGRGAPGDGALHVTEALLDQVLHHLGQVVGGVVEERQQVGPDELGAVLYHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SLQ1</accession>
    <name>A0A433SLQ1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="2">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_022167</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="2"/>
    <dbReference type="EMBL" id="RQTK01001497">
        <property type="protein sequence ID" value="RUS70075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SLQ1"/>
    <dbReference type="STRING" id="188477.A0A433SLQ1"/>
    <dbReference type="OrthoDB" id="8193983at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050151">
        <property type="entry name" value="Class-I_Pyr_Nuc-Dis_Oxidored"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912">
        <property type="entry name" value="DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912:SF93">
        <property type="entry name" value="SOLUBLE PYRIDINE NUCLEOTIDE TRANSHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="6">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS70075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="135" mass="14996" checksum="99E3450197E2F20D" modified="2019-05-08" version="1" fragment="single">IYGAGVIGCEYASILSTLKIQINLVNTRDKLMSFLDGEIINTLSQHFTVNQGIHLIHNEIYKSIEATDDKVITTLESGRVIESDYLLFSLGRSGNVNGMNLEKIGIDFNKTRGLIQVNDNYQTNIDNIYAVGDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SLY2</accession>
    <name>A0A433SLY2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_022078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001477">
        <property type="protein sequence ID" value="RUS70159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SLY2"/>
    <dbReference type="STRING" id="188477.A0A433SLY2"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017178">
        <property type="term" value="F:diphthine-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06156">
        <property type="entry name" value="eu_AANH_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030662">
        <property type="entry name" value="DPH6/MJ0570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196:SF2">
        <property type="entry name" value="DIPHTHINE--AMMONIA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION 71 DUF71 -CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS70159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="255" mass="28254" checksum="8DFB90C1AB6D7061" modified="2019-05-08" version="1">MAGIVPLVPATLQPVKGGIGVQSLLALTHVQSVMSAIAPNCSLNCCPLVICYITNSEYTEICHHQWKQALKTRKTESEQFGEKQSSLNPCIQFVQVSALPKACLVEWHVLAWPELQDCEICEVKQAKHCENYCIQAVAQHCADKPTLFSSHITLEVTNFEGLQRAEKVNLPSQMVEMFCQVWGQSFPSATSRDTGAMPLVKIFFSPTIYDFNLLHKYFMKAVAISCSSHAVPEPAISLVPVSGLDSRKQILAWCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SMX4</accession>
    <name>A0A433SMX4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nbr1 FW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_021711</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001390">
        <property type="protein sequence ID" value="RUS70523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SMX4"/>
    <dbReference type="STRING" id="188477.A0A433SMX4"/>
    <dbReference type="OrthoDB" id="661148at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14947">
        <property type="entry name" value="NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14349">
        <property type="entry name" value="UBA_CF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039517">
        <property type="entry name" value="C6orf106_UBA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032350">
        <property type="entry name" value="Nbr1_FW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930">
        <property type="entry name" value="OVARIAN CARCINOMA ANTIGEN CA125-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930:SF0">
        <property type="entry name" value="PROTEIN ILRUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16158">
        <property type="entry name" value="N_BRCA1_IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nbr1 FW" evidence="2">
        <location>
            <begin position="83"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS70523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="231" mass="25481" checksum="33AFB08583E849B9" modified="2019-05-08" version="1">MDVDVDNEFDGELLNQFRTLGTTDRDVLIAEFQAVLGNTLNPESCAFFLDMNDWNLQNAVCSYYDLEQPVSILPSMRVLEDITLGNGEAVAPNTTFVKAWRIKNSGSDHWPPGCQLQYYSGDSMCAIERRVLPALSPGESTEVSVEMKSPATPGFYNSIWRVFTPTGTMFGDPIQWSIAVSEGGLLGITQQLARIDGGGLNSEVQMAIQQQQHQEMATLSPSKVEEDTEMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SNA9</accession>
    <name>A0A433SNA9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Annexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EGW08_021568</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">EC2010</strain>
            <tissue evidence="17">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Involved in reproduction of the worm. Involved in host-parasite interaction. Delivered into the host cell by means of parasite exosomes. Binds to acidic phospholipid membranes in a calcium-dependent manner in vitro. Causes aggregation of liposomes in the presence of calcium, but not in its absence. Likely to promote membrane fusion. May provide structural integrity within the tegument.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host cell</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular exosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Tegument</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">A pair of annexin repeats may form one binding site for calcium and phospholipid.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the annexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001357">
        <property type="protein sequence ID" value="RUS70669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SNA9"/>
    <dbReference type="STRING" id="188477.A0A433SNA9"/>
    <dbReference type="OrthoDB" id="37886at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043657">
        <property type="term" value="C:host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000001">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000002">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000003">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000004">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000005">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018252">
        <property type="entry name" value="Annexin_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026876">
        <property type="entry name" value="Fn3_assoc_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF239">
        <property type="entry name" value="ANNEXIN A7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="8"/>
    </dbReference>
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        <property type="entry name" value="Fn3_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00223">
        <property type="entry name" value="ANNEXIN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10 15" id="KW-0041">Annexin</keyword>
    <keyword evidence="8 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 15" id="KW-0111">Calcium/phospholipid-binding</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="125"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="359"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="452"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="125"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="477"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00060393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RUS70669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1186" mass="130620" checksum="E76201DAC27334AC" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SNR0</accession>
    <name>A0A433SNR0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L23</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_021389</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001321">
        <property type="protein sequence ID" value="RUS70851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SNR0"/>
    <dbReference type="STRING" id="188477.A0A433SNR0"/>
    <dbReference type="OrthoDB" id="407959at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_uL14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS70851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="151" mass="16078" checksum="F19CE95C7138FF2E" modified="2019-05-08" version="1">MSKRGRGGSAGGKFRIALGLPVGAVINCADNTGAKNLYVIAVSGIKGRLNRLPAAGSGDMFVATVKKGKPELRKKVKKGKPELRKKVMPAVVIRQRKPFRRKDGMFLYFEDNAGVIVNPKGEMKGSAITGPVAKECADLWPRIASNASSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433ST64</accession>
    <name>A0A433ST64_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_019810</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001068">
        <property type="protein sequence ID" value="RUS72431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433ST64"/>
    <dbReference type="STRING" id="188477.A0A433ST64"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16796">
        <property type="entry name" value="RING-H2_RNF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000824">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF20">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019285845" description="RING-type domain-containing protein" evidence="11">
        <location>
            <begin position="36"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="244"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="293"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="348"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="395"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="503"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="319"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="510"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS72431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="558" mass="61757" checksum="B19BFF5DF39DFBD4" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SVV4</accession>
    <name>A0A433SVV4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_018810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000938">
        <property type="protein sequence ID" value="RUS73422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SVV4"/>
    <dbReference type="OrthoDB" id="8196546at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS73422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="129" mass="14689" checksum="E070637CD9EE168C" modified="2019-05-08" version="1">MKDNSSLQQHIEASPKATLTLYVTSGAYQSAVIGEVLDKVGMQKSELLQLIQRRKLAYYGHIRRHCSIQKRVVEGKVEGKRGRGRKRQSWLANIQETSQLRLSVACEAALDRERWRRMTAHLGDGTAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SVW3</accession>
    <name>A0A433SVW3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EGW08_018805</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">EC2010</strain>
            <tissue evidence="17">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoplasmic ribonucleoprotein granule</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="RQTK01000937">
        <property type="protein sequence ID" value="RUS73430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SVW3"/>
    <dbReference type="STRING" id="188477.A0A433SVW3"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036464">
        <property type="term" value="C:cytoplasmic ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18078">
        <property type="entry name" value="DEXXQc_Mov10L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000608">
        <property type="entry name" value="Mov10 RISC complex RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049080">
        <property type="entry name" value="MOV-10-like_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049079">
        <property type="entry name" value="Mov-10_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025223">
        <property type="entry name" value="S1-like_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45418">
        <property type="entry name" value="CANCER/TESTIS ANTIGEN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45418:SF1">
        <property type="entry name" value="CANCER_TESTIS ANTIGEN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21634">
        <property type="entry name" value="MOV-10_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21635">
        <property type="entry name" value="Mov-10_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14444">
        <property type="entry name" value="S1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="S1-like RNA binding" evidence="14">
        <location>
            <begin position="218"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase MOV-10 helical" evidence="16">
        <location>
            <begin position="332"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase MOV-10-like beta-barrel" evidence="15">
        <location>
            <begin position="376"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="12">
        <location>
            <begin position="567"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="12">
        <location>
            <begin position="676"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="13">
        <location>
            <begin position="757"/>
            <end position="970"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF21635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RUS73430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1017" mass="115469" checksum="79F04DCDCDDBFB24" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SVX5</accession>
    <name>A0A433SVX5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleoporin Nup133/Nup155-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_018813</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the non-repetitive/WGA-negative nucleoporin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000938">
        <property type="protein sequence ID" value="RUS73425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A433SVX5"/>
    <dbReference type="OrthoDB" id="338970at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.440:FF:000001">
        <property type="entry name" value="Nuclear pore complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1880">
        <property type="entry name" value="Nucleoporin, helical C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.440">
        <property type="entry name" value="Nucleoporin, helical domain, central subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.450">
        <property type="entry name" value="Nucleoporin, helical domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004870">
        <property type="entry name" value="Nucleoporin_Nup155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042533">
        <property type="entry name" value="Nucleoporin_Nup155_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042537">
        <property type="entry name" value="Nucleoporin_Nup155_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042538">
        <property type="entry name" value="Nucleoporin_Nup155_C_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="6">
        <location>
            <begin position="80"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="5">
        <location>
            <begin position="644"/>
            <end position="1340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS73425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1366" mass="152457" checksum="8141600093F0A116" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SWM4</accession>
    <name>A0A433SWM4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_018516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000907">
        <property type="protein sequence ID" value="RUS73710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SWM4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS73710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="238" mass="26290" checksum="391DA837951B3C84" modified="2019-05-08" version="1" fragment="single">HLVAFVGSLIVEYEVAVVQEKQTEQHGEHEEGADQEDAAGLLHEQRTQCCTDLQEDGQRDGQHVSGAGVEVAAVHEVEVLRVQGHRSGAHHRPVDDHGQQREQEGHEEAQVAGTHAVVDPDTVVVEAVHTPVTDTWVVMGDSVSATNRIVTLRASLVYGPVRRVHRSQRGHVLRSHTARVHRAAQVERRGVDKHEQHGHQQVVLPGLEDVQQRQDVAHQDGVSSHDEATKHQLHHVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SXV3</accession>
    <name>A0A433SXV3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_018229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000876">
        <property type="protein sequence ID" value="RUS74000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SXV3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="475"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="533"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="245"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="549"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="590"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS74000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="600" mass="70629" checksum="BB696F5B4A99DB1E" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T374</accession>
    <name>A0A433T374_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TROVE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_016216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000693">
        <property type="protein sequence ID" value="RUS76011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T374"/>
    <dbReference type="STRING" id="188477.A0A433T374"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS76011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="625" mass="69684" checksum="53FAC5EA0F561619" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T466</accession>
    <name>A0A433T466_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_015877</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000669">
        <property type="protein sequence ID" value="RUS76347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T466"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052983">
        <property type="entry name" value="MFS_Riboflavin_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43385">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER RIBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43385:SF1">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER RIBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS76347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="38902" checksum="5A868B57C8CC53C0" modified="2019-05-08" version="1" fragment="single">WKKACSLIGAHLITSPMSFMYIYGNLIAYVDSYLQLKCSDRCLDADTQWILALYVAGQFPGAFIVQPLLKKVGPRWSGMITMLICNAAIILSAWTLQHSVLWTVFLYGLLVGPCVGISCALSLHVVNAWSPMRAGFLMATVSGYPTVLSMVQNQVITSYVNPDNLEADKMIGLKTYFSQPQLLNRAPIFYSLFLFGVATEQTIMTKAYFYKEFGQIYINNDKFLTLVGSIEPIISILFRIVFGALLDTHILSIKHCILYSLALNSVLCFFWYFVPQVSALLYLFLLLSLSVSHSLLYVVTLCAGLKLFGQDHLLTNFGLITSFLLVGSLITPIVVNVLLGNLGWFWLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T4A7</accession>
    <name>A0A433T4A7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_015854</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000667">
        <property type="protein sequence ID" value="RUS76374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T4A7"/>
    <dbReference type="STRING" id="188477.A0A433T4A7"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000770">
        <property type="entry name" value="zinc finger protein 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050758">
        <property type="entry name" value="Znf_C2H2-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234:SF10">
        <property type="entry name" value="RIKEN CDNA 6720489N17 GENE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234">
        <property type="entry name" value="ZNF44 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="186"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="300"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="328"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="356"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="87"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="597"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="605"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS76374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="751" mass="84801" checksum="BDCD0CF14F96DFE1" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T521</accession>
    <name>A0A433T521_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_015595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000647">
        <property type="protein sequence ID" value="RUS76647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T521"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS76647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="145" mass="14542" checksum="7CB67945451AAF95" modified="2019-05-08" version="1" fragment="single">MGGPSSSGGPGIGGGGGGGVGGSGGGGGGNSNDKSINILKHLLSKEDDDDEMLESGLPSPAFSSSSAGGQGLDFASALANSGVPGGGTKNEAEPRKTHALLKQLLGDDAKKQQQLSGAVTQATIEEKIRLELENRQKLQQHQQQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T9V1</accession>
    <name>A0A433T9V1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_013875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000515">
        <property type="protein sequence ID" value="RUS78355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T9V1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS78355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="203" mass="22064" checksum="1402E9E738DC9985" modified="2019-05-08" version="1">MRDGGVKVVQNGGTGPLGKPRRQTNGQSKKKGDVLVNGSGKTNGHGPAEGKSGHMGQAKVQSQTKTDGDLGLTQAVAELDLDDDPEDKSDASSSSSESSYFITNLPRRKSVQIDQERALKECRKLQRVRSIPVQLGVKEYRVLHGPIHVDHRKRKLIIHLDIRNTILVADSITNVSVEEVCGLLDLVYSTCSSVWPLSISDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TA07</accession>
    <name>A0A433TA07_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_013844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000512">
        <property type="protein sequence ID" value="RUS78396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TA07"/>
    <dbReference type="OrthoDB" id="10065837at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS78396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="223" mass="24433" checksum="4F4F11EEB5041D80" modified="2019-05-08" version="1" fragment="single">TAAAAVVGHLVLRQARRLGLVVDQRGVGVQRLGHLVADDVHQPLKHRLHIDVLLGRCLEKLQTWQLTERSGLIGELLAAVCADHPLVLQVTLVAHQHHLGVVPRVRLDLEHPPVLHGLERLLVGDVVHQQEAHGAAVVRSGDGPIPLLTRETHPDLQFDPLVLAEHGLDLEVDADRADKGRRERVVCVAEQEGRLAHTTVADDEQLEHVVEVLVRGVLLPFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TCL8</accession>
    <name>A0A433TCL8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_012873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000456">
        <property type="protein sequence ID" value="RUS79352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6123481at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="663"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1579"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1625"/>
            <end position="1647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1686"/>
            <end position="1715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1990"/>
            <end position="2025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2152"/>
            <end position="2181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2219"/>
            <end position="2260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2335"/>
            <end position="2365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2379"/>
            <end position="2412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2509"/>
            <end position="2544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2557"/>
            <end position="2593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2610"/>
            <end position="2661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2780"/>
            <end position="2802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2851"/>
            <end position="2874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3207"/>
            <end position="3227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1629"/>
            <end position="1645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1990"/>
            <end position="2006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2008"/>
            <end position="2019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2153"/>
            <end position="2163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2219"/>
            <end position="2245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2385"/>
            <end position="2399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2529"/>
            <end position="2538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2562"/>
            <end position="2576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2577"/>
            <end position="2590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2610"/>
            <end position="2619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2637"/>
            <end position="2661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2851"/>
            <end position="2867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3210"/>
            <end position="3223"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="3329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS79352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="3329" mass="376056" checksum="3ECFA9C2988CABDE" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TEC8</accession>
    <name>A0A433TEC8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_012325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000421">
        <property type="protein sequence ID" value="RUS79911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TEC8"/>
    <dbReference type="STRING" id="188477.A0A433TEC8"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24002">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24002:SF3">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS79911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="28095" checksum="6D35835DBC0A8290" modified="2019-05-08" version="1" fragment="single">GCFKHSQTISRAFLSDEGQSTPLAQATLLGNFNSFSAIGFIVGPVVGGHMAETEAGFSLVACTAGLVFLLNAALVWCMVPPGPKGSHPPRIHEEGSEMQLTRSETALSMEKVGSEEINLNIRKVLRSFKDFNWPQLWDLLLMRFFAGFSIIIFRSNFTMVLKLKFKASPSTIGYMTSFSGIIAALSGFCIGALIKRYKNNNARLLLHATILQVASLACLTVAPSLSVLLLALVPLNLVTSVSRVGITILTVESASASPKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TEY5</accession>
    <name>A0A433TEY5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_012110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000410">
        <property type="protein sequence ID" value="RUS80111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TEY5"/>
    <dbReference type="STRING" id="188477.A0A433TEY5"/>
    <dbReference type="OrthoDB" id="2420415at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20485">
        <property type="entry name" value="USP25_USP28_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF944">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="3">
        <location>
            <begin position="198"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="497"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="651"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="760"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="443"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="581"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="508"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="773"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="804"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS80111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1185" mass="129690" checksum="1666514FFA87C3E3" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TG02</accession>
    <name>A0A433TG02_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Intraflagellar transport protein 172 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_011738</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the IFT172 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000387">
        <property type="protein sequence ID" value="RUS80517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A433TG02"/>
    <dbReference type="OrthoDB" id="2186662at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000008">
        <property type="entry name" value="Intraflagellar transport protein 172 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000012">
        <property type="entry name" value="intraflagellar transport protein 172 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000013">
        <property type="entry name" value="intraflagellar transport protein 172 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002910">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056168">
        <property type="entry name" value="TPR_IF140/IFT172/WDR19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056157">
        <property type="entry name" value="TPR_IFT80_172_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722">
        <property type="entry name" value="IFT140/172-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722:SF2">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 172 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24762">
        <property type="entry name" value="TPR_IF140-IFT172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23387">
        <property type="entry name" value="TPR_IFT80_172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IFT80/172/WDR35 TPR" evidence="11">
        <location>
            <begin position="626"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="808"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="IF140/IFT172/WDR19 TPR" evidence="12">
        <location>
            <begin position="962"/>
            <end position="1180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF24762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS80517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1757" mass="198073" checksum="558462B4978CA5D9" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TG36</accession>
    <name>A0A433TG36_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_011719</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000386">
        <property type="protein sequence ID" value="RUS80535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TG36"/>
    <dbReference type="STRING" id="188477.A0A433TG36"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22031">
        <property type="entry name" value="HMG-box_SoxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000004">
        <property type="entry name" value="Transcription factor SOX-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022151">
        <property type="entry name" value="Sox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050917">
        <property type="entry name" value="SOX_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45803">
        <property type="entry name" value="SOX100B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45803:SF5">
        <property type="entry name" value="SOX100B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12444">
        <property type="entry name" value="Sox_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="8">
        <location>
            <begin position="184"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="6">
        <location>
            <begin position="184"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="76"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="240"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="376"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="462"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="282"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="381"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="407"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="430"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="472"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="485"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="503"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="522"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="532"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="554"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS80535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="656" mass="69192" checksum="E50C6CA8053B6AC2" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TK68</accession>
    <name>A0A433TK68_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EGW08_010273</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">EC2010</strain>
            <tissue evidence="17">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 19">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="EMBL" id="RQTK01000312">
        <property type="protein sequence ID" value="RUS81958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TK68"/>
    <dbReference type="STRING" id="188477.A0A433TK68"/>
    <dbReference type="OrthoDB" id="6219513at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009925">
        <property type="term" value="C:basal plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038127">
        <property type="term" value="P:ERBB signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000027">
        <property type="entry name" value="Receptor protein-tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.220.10:FF:000001">
        <property type="entry name" value="Receptor protein-tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.20.20">
        <property type="entry name" value="Receptor L-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006211">
        <property type="entry name" value="Furin-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032778">
        <property type="entry name" value="GF_recep_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000494">
        <property type="entry name" value="Rcpt_L-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036941">
        <property type="entry name" value="Rcpt_L-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF566">
        <property type="entry name" value="EPIDERMAL GROWTH FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00757">
        <property type="entry name" value="Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14843">
        <property type="entry name" value="GF_recep_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01030">
        <property type="entry name" value="Recep_L_domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="733"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein kinase catalytic" evidence="16">
        <location>
            <begin position="804"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RUS81958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1021" mass="114134" checksum="C0359E7A65E4F011" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TKX6</accession>
    <name>A0A433TKX6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_009991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000295">
        <property type="protein sequence ID" value="RUS82253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TKX6"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="463"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS82253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="476" mass="50941" checksum="389B53440BDF08A1" modified="2019-05-08" version="1">MSDGSRATLTNLPTERAANGGKDQDVNHDGDDESNNSREIPLSSRLTKLSRSRSRSQSPAIFPPAPSSALFQNAQRFNNSRSQYSSDASESGSTSVRQEPRDRLPTPSSESKHNNRPKSQGAYSKRRDRRHRTLTSVPPPTVPRLSATNRSFSGSGQNHSETNSPTSEKSFPIIKINVGKQKSQTLPENNKINENPELRHGDVLKLPAQSTFGATTQEAPKKDNEDPRLLQIQGYTDIPLPQLSHRNGDKTSNNNEIPDTKTYQSGSEAVVFTTSSDPSILSPEATNCPSTDLRKLYNQARVGEEDAAPNRDSLRDLVPGTVSGIVQQINKLSPASMSPSSNSTDKSNGTASSSGSYGNGSCENLHVKGSLSETEEIGDVDNASEVLLETPEPTVSNNASDGSDNHLSKSDNHKPSNPSERLNNQLQISNDHGDRAESPATSPSAVPNGVATQEHPASLDLQATGSSAADAGTSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TL00</accession>
    <name>A0A433TL00_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_010058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000299">
        <property type="protein sequence ID" value="RUS82176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TL00"/>
    <dbReference type="OrthoDB" id="10247241at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS82176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="240" mass="27736" checksum="8A648E720624DAD3" modified="2019-05-08" version="1">MKRSPSTDRSSDHHLRTDPTITIYGQIQRSPSTDRSSDHHLRTDQAITIYGQIQRSPSTDRSSDHHLRTDEAITIYGQIQRSPSTDRSSDHHLRTDQARGGKNPETREIEKATERRPKVNPETREIEKATERRPKVNPETREIEKATERRPKVNPETREIEKATERRPKVNPETREIEKATERRPKVNPETREIEKATECRPKVNPETREIEKATVPQGRPDTLTSGRQILPSDRGMPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TM95</accession>
    <name>A0A433TM95_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_009540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000275">
        <property type="protein sequence ID" value="RUS82703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TM95"/>
    <dbReference type="STRING" id="188477.A0A433TM95"/>
    <dbReference type="OrthoDB" id="6139845at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052751">
        <property type="entry name" value="Plant_MAPKKK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48011">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTIONAL COMPLEX SUBUNIT CAF120-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48011:SF4">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="90"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS82703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="890" mass="99735" checksum="36452DCB24D2BFCB" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TMM0</accession>
    <name>A0A433TMM0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_009405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000269">
        <property type="protein sequence ID" value="RUS82829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TMM0"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS82829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="150" mass="16727" checksum="E7A7883D452D9B48" modified="2019-05-08" version="1">MCFTPNPVAFFRLVVFFNSVKRIFKLGTVPESMNHTGKLFHAAVVVCLLAIFLASSHGFLVDLPDDKGGGRHPKPDATSSPHTTRASSDVGDKGRITTPKINDATTVHGNHKPVDSKFDKCYKDCYQDDDDVNLQHYCYRQCMFDPDSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TMV3</accession>
    <name>A0A433TMV3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Globin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Myoglobin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_009335</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the globin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000266">
        <property type="protein sequence ID" value="RUS82912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TMV3"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="8" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="9">
        <location>
            <begin position="24"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS82912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="131" mass="15044" checksum="E239239171D1B13A" modified="2019-05-08" version="1" fragment="single">MGGKATQCCKTGSFQKGHPNPVTGLTKNDVRLLRDSWKQMEHQRLILPIGRDNFISLFESYPHLLMFFETFSLKEQKPPSNQKLCAHALVFMKALRLYLDYIDEPDVEVGLLHTMSLSHLQRLISSQDVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TPA4</accession>
    <name>A0A433TPA4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_008819</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000244">
        <property type="protein sequence ID" value="RUS83398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TPA4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS83398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="82" mass="8558" checksum="EC8C4201873954AB" modified="2019-05-08" version="1" fragment="single">ALNLALDIALDIALDVAQDIALDIALEEALDMALDIALDIALDIALDIALDEALDIALDIVLDIALDIALDIVLDIALDVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TPS1</accession>
    <name>A0A433TPS1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_008671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000239">
        <property type="protein sequence ID" value="RUS83565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TPS1"/>
    <dbReference type="STRING" id="188477.A0A433TPS1"/>
    <dbReference type="OrthoDB" id="6258470at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46238:SF8">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46238">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS83565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="278" mass="31599" checksum="E78920DEEB98CB1A" modified="2019-05-08" version="1">MHGATIVIGLKRLTKDSDFKCSRCQGTARPIDGRPQSEVQVGSDKLDVVASFCYLGDMLSAAGGCDLATTTRVKTAWKKFKELLPVLLSRHLSYKTRGHVYSTCVRSAMLHASETWPLTKPNLQRLQRNDRAMIRQICNVKPEDVATTRSNELLTLLGLEDLNLILKERRLRWYGHVERSSGAIKTALDMQVTGSRGKGRPRMTWKQVTERDRKDWKLSTTDPHDRNTWRSGVRSAMRAASQLPGRGPLMWMLPQYLHVNQNTDDDDDDDDNDDDFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TPW4</accession>
    <name>A0A433TPW4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_008597</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000236">
        <property type="protein sequence ID" value="RUS83629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TPW4"/>
    <dbReference type="STRING" id="188477.A0A433TPW4"/>
    <dbReference type="OrthoDB" id="6159389at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052560">
        <property type="entry name" value="RdDP_mobile_element"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36688">
        <property type="entry name" value="ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36688:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS83629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="418" mass="46096" checksum="6548DB23A1EEA7F9" modified="2019-05-08" version="1">MEKAFDRVWKDGLRLKLRKNGISRCMFKWISQYLNNRKARVHVNGTYSRKKTLREGVPQGGVLSPTLFLIFINDIVKDLPRNVHGAICADDLVLWCSEEYTSTADYRLQEALNILEKWTKQWLKTINSAKTTYTAFGLSTKEQKVTLKLNGQALPAEDNPTYLGVTFDKRLTWKEQTEKAEVRAKARLAIMKKLAGTQWGANARILKTMYTGRVRPVLEYGVSACVSAWGTAAKSNLDKITKVQNQATRVITGAMKSTPIKELETITGLAPIVQRKDSKLLIQAAKFRQTARAPNERQNVTTSEKEAEKGEFSTSNLDGRLVVKATLPHNNPSTLSDEDGDINAAAAAAEYDGDDDDDDDDDDDDDDDDDYDNAAATAAVAVVAAAADDDDDDDNNNNINNNNDDDYVGGGGGGGRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TS54</accession>
    <name>A0A433TS54_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucose/Sorbosone dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_007782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000205">
        <property type="protein sequence ID" value="RUS84453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TS54"/>
    <dbReference type="STRING" id="188477.A0A433TS54"/>
    <dbReference type="OrthoDB" id="10266706at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH_b-prop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19328:SF75">
        <property type="entry name" value="ALDOSE SUGAR DEHYDROGENASE YLII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19328">
        <property type="entry name" value="HEDGEHOG-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="Soluble quinoprotein glucose dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose/Sorbosone dehydrogenase" evidence="1">
        <location>
            <begin position="91"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS84453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="433" mass="48313" checksum="A2411AF0CB88E923" modified="2019-05-08" version="1">MYESRSKALKTMASSRIDLTTYRVKLLARNGQDVKTSFCTRTAPKNSSVCYPDVTSLPTDEAPPNPRCVCFEPTNRWLSMPVWAGHAGDGSGRLFVVEQRGKVSIYNTRTRTWKNKLFMDIRSEVLISLEKGDEKGLLSLAFHPNYTNNRRLFLFYALSRDPSEPLPEEYQSRSFTYTFKVRVSEMLVREDNPDAVDVSTEKILLEVLQPFQWHNGGAMFFGTDSYLYISFGDGGGGGDPFMGAQDNTLLHGTVIRIDVDSNTSVPYTIPPDNPFVGQPGAGRGRILCGDVGQEKYEEMDVLEPGANYGWPAREGNNCYNDQCGQIGPEVYPAFSYNHTLGKSVTGGVFYRGCENKGLNGTHVFGDYKTRVLLTMDEDEDGNWTSGELPLCLDRCPNGLEKYVHGGIMSFGEDEQGYKTYTALGLGSASYRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TSS9</accession>
    <name>A0A433TSS9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_007617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000200">
        <property type="protein sequence ID" value="RUS84590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TSS9"/>
    <dbReference type="OrthoDB" id="6216076at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS84590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="393" mass="44143" checksum="4ECD8862719136C0" modified="2019-05-08" version="1">MKSNHGWRDQKSAAEEQYRRPVFVDWAKEKPFTETGLSGAAQEVCKEIEKDSNLTLGRDADKKFASENETAEEQYRRLIFVDWAKEKPFTETGPSTTRNASGPSTADIAPRPSTATNAPRPSMPSTHRTSTAGTKTFHAINAPGLSTATNEPGSSSGTPKQHQQIDSNANYFKEKTKSMNLTPDQYARATLNLLNPRTPEKRVCIAEQQMRHPCRVLFAAQDVMPNLENELGIEALDVEQNLTQQAFYRRDDVSRMLPHARLKICCLNRALRSSQLPSERRMLNFLCCPVNAPNFNNIDYINGKVVMIQDFARTTKPAMQKRSMEQNTSDETSTSASERRIAQMFNVNDALIMLDTLPTDYSTCTDEEPDSDPDDPDFEPDPQPSLSNIDRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TT29</accession>
    <name>A0A433TT29_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_007542</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000196">
        <property type="protein sequence ID" value="RUS84714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TT29"/>
    <dbReference type="STRING" id="188477.A0A433TT29"/>
    <dbReference type="OrthoDB" id="296632at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12421">
        <property type="entry name" value="RRM1_PTBP1_hnRNPL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12423">
        <property type="entry name" value="RRM3_PTBP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000341">
        <property type="entry name" value="Hephaestus, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006536">
        <property type="entry name" value="HnRNP-L/PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021790">
        <property type="entry name" value="PTBP1-like_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01649">
        <property type="entry name" value="hnRNP-L_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15592">
        <property type="entry name" value="MATRIN 3/NUCLEAR PROTEIN 220-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13893">
        <property type="entry name" value="RRM_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11835">
        <property type="entry name" value="RRM_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="41"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="155"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="331"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS84714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="425" mass="45854" checksum="74242D9AD9C919D5" modified="2019-05-08" version="1">MEGEFFSSCGVKRGPGNMQVNDGMGDANDVKKAKLENTPSKVIYIKSLPNDATDADVVHLGMPFGKVTNVLVLRHKNQAFLEFADESCAVNMVTCYKINPAQIRLKSCYVEFSTHKELKTDLSNNVQVALQGAQGLQGASNGAAQGGLGEQTSILRVIVDKLLYPVTLEVLHQLFSRYGKILKIITFSKNNIFQALIQFGDRISAVAAKDSLDNQNIYNGCNTLKIEFSRMTNLNVKYNNDRSRDFTRNDLPTGDGIGNDIGLMTQTDMGFGGMGGAGVLGSGANALMGGLGGLGGGAFNLGGNMMGNMAGQFNNRTENNPGMNQPTAGSPCILVSNLDEERVTPDALFTLFGVYGNVHRVKILYNKKDNALIQMADSSQAMQAITYLDKVRVWGKQLRVGSSKHQMIQLPKEGQSVSDSLNSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TTK6</accession>
    <name>A0A433TTK6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_007368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000190">
        <property type="protein sequence ID" value="RUS84899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TTK6"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48147:SF3">
        <property type="entry name" value="MYELIN TRANSCRIPTION FACTOR 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48147">
        <property type="entry name" value="PROTEIN CBG23787"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS84899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="455" mass="52049" checksum="92F8D9439019D815" modified="2019-05-08" version="1">MTLLSLEALTFFCSAHFISKTGKKGLLNVDDRLRRILSSPRPTLTTVSHSKTFGPTASFDGAREVGRLTSHLSSGERSYVPVNDPHLLKPLEFPEKPTDYENAPMERSYELHLRLKTNQSFTNQVSVKNRTRRIRKRYGLQQVSFLNKENLLRPTIFKRRPGLEGKSPQSSSSGSQTRLPIALPWRQQAEIYSVPPSLLDNSPNSTFPRRTGLTDLRKPRSKRNAKNLIFEKVYQFKPSIRVSRLSSEADQLHPRDIQLEVAHIPNDSNPSLYKAQSLKSARSTSTVPKSKNDNSAGSNPLSRQSDASFQEPEGQTASGQHVKLVEITSSWCQPIYDDHDVHHLVFVICNEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEAFHLRQCCEFLTKTKMDNLGYSNDQEDRDDPVMTGGVGSPRASFYEMNILKGSWAADEKEDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TTP2</accession>
    <name>A0A433TTP2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_007292</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000188">
        <property type="protein sequence ID" value="RUS84930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TTP2"/>
    <dbReference type="STRING" id="188477.A0A433TTP2"/>
    <dbReference type="OrthoDB" id="2261376at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS84930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="31047" checksum="F38E6263DC3B1E74" modified="2019-05-08" version="1">MKGKMKQAAAQTHRICKANKIPFPQEVWSSMKKSKGAQSQETRQHNYNVTHLFRTMLLMKITLISMFLWITIASTYYGLTFKVTSLKGNPYFNFFISGLLEFTMAALCLPIMNRFGRKKPLVVGFIFCSAMCLTSGFVNSYTTGYDKLVTAFGLVGKCAGSCIFIVFFVYTTELYPTVIRNVGLGLGMFWARLGGVMAPQINEWTSVLFGFDVIYLFGTLSLIGGLIVLPLPETHQKRLPDTIEEEVTIPAEACALTDKAEEEDAIGTLLGRKSSSENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TVU7</accession>
    <name>A0A433TVU7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_006511</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dermatopontin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000161">
        <property type="protein sequence ID" value="RUS85717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TVU7"/>
    <dbReference type="OrthoDB" id="5975249at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030199">
        <property type="term" value="P:collagen fibril organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026645">
        <property type="entry name" value="Dermatopontin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15040:SF1">
        <property type="entry name" value="DERMATOPONTIN-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15040">
        <property type="entry name" value="DERMATOPONTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14704">
        <property type="entry name" value="DERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019173666" evidence="5">
        <location>
            <begin position="19"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS85717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="181" mass="20257" checksum="958555C2DE3CD43A" modified="2019-05-08" version="1">MALTLVAGVLFASLSASAGWMTDWDQHFTFSCPDNQMLKTIESIHDNGKEDRVFNFGCTPLPGGASLSGCEWSGYANDFDQLLEFQCHNDAVIAGIDSYHDNGKEDRRYKFRCCNPVGMVSHACEYTGIINNYDAHLLYRAPDGMAIKGVSSRHDNGKEDRQFWFDICKLDRLVLGEEIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TWS2</accession>
    <name>A0A433TWS2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_006204</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000152">
        <property type="protein sequence ID" value="RUS86050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TWS2"/>
    <dbReference type="STRING" id="188477.A0A433TWS2"/>
    <dbReference type="OrthoDB" id="6155286at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000102">
        <property type="entry name" value="Aristaless related homeobox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003654">
        <property type="entry name" value="OAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF543">
        <property type="entry name" value="FI01017P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50803">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="330"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="OAR" evidence="10">
        <location>
            <begin position="558"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="332"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="118"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="530"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="155"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="210"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="234"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="536"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="563"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS86050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="586" mass="62849" checksum="87C8BA61B5F84520" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TZ91</accession>
    <name>A0A433TZ91_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_005373</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000125">
        <property type="protein sequence ID" value="RUS86894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TZ91"/>
    <dbReference type="OrthoDB" id="6147740at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="116"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="116"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS86894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="201" mass="22310" checksum="347439A2F0B5FDD5" modified="2019-05-08" version="1">MANSYVCSLACADLVVGAVCVLLAIYLLPPFRVGWFDKYEVMCSLLNGLNIGMTVVSAFSMTLIAVDRYVWNLVVVVVVGICFTVNFDGKFCDLRVCAVGRCGVFSVAVIGRFGPFDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDNDNDNNDTVSLIKYILYCNIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TZQ3</accession>
    <name>A0A433TZQ3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_005283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000123">
        <property type="protein sequence ID" value="RUS86958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TZQ3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS86958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="324" mass="34318" checksum="64BE596D88A32E3F" modified="2019-05-08" version="1">MSGRARPGRTTVTTPRALHAWSPHAALCAWLDWLTSAPPSPGKPIRNKSITGEWLPLRGRGIRKELSQRYAEINGALSWQQIGDPLRGNSGAKTCASEKDCSLIAGAVVGSLASEVSLRLQMSDHSTPIACRGVHAAQGGPARYAEPTSPSQPVLAATHCLQVEADTMCIPDFKMLPTLTWLSVPVLLREARRGGFAGLAVSSCLGGIPIVVIISLPTAGDLRETWPMAFSVKQAGDLSTESICLAASCVHLGQWLKEIFGYVIPKSNCGCVIAAGQRRTVQKAECRTKDAIPARNPGSAGISRGGAPSSDRVRPSVKRRASVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U143</accession>
    <name>A0A433U143_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_004702</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000108">
        <property type="protein sequence ID" value="RUS87526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U143"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019434073" evidence="2">
        <location>
            <begin position="22"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS87526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="124" mass="13792" checksum="DBDD99C55505EF6F" modified="2019-05-08" version="1">MNLKLVSLCLVVSVLAGSTLATQVEDFARVLQQVSRTLERIPKKRVCQGYMCSYGHNSDSASKAAVHKVLLHYLYQCAMDNTCHHQGKRRRRSSSASAPSSVSSNSKMSLRKLTQYKSQNSARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U2B2</accession>
    <name>A0A433U2B2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_004356</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000098">
        <property type="protein sequence ID" value="RUS87878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U2B2"/>
    <dbReference type="OrthoDB" id="10266980at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071709">
        <property type="term" value="P:membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055091">
        <property type="term" value="P:phospholipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097035">
        <property type="term" value="P:regulation of membrane lipid distribution"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF4">
        <property type="entry name" value="TLC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="51"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS87878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="267" mass="30359" checksum="E1FC96ACD85F02BE" modified="2019-05-08" version="1">MASETKAANAEIWRDDINDPNYGYHIVALSTAMFFILSRIVVFCVPQVAKKSTWKWKNIMVSFIHSIISSIWAVACFYERPDMAEDLITVFTVLSHSLTSFSVGYFVYDLFDLMTTRSSRQSVELMGHHVVIITCFMVAVCWRHYVGYAVVALLVEINSVFLHFRQLLQICGVSKFNGWYRLNSLTNLATFIVFRILLLSWMTRWMVINRDAVPLVFYSLGSVGLAVMVAMNITLFYRLLRSDFISLKDTDDSACGGTAAPTCKKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U4V0</accession>
    <name>A0A433U4V0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_003387</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000072">
        <property type="protein sequence ID" value="RUS88842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U4V0"/>
    <dbReference type="OrthoDB" id="6123720at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="203"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS88842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="295" mass="34276" checksum="5B0D25975ACD03C3" modified="2019-05-08" version="1">MEFLLQNPIFRARMKSLTPATRRWFIESLIDLFDQESEYVIDVIEDCRQEMRDTADSYRGDAEELRAKSRMLHERRMSPSPDRSVSRQSTSVSSRLSFAPDRQGTQDSLLTTRRGHRRRRILNSDGDGYIPSPTPRPGDGSGANQRCASSLSVPSLPALVSSVRGPSPSARTTRSLPVTPSVPTEEEQLQQKRRMHDESRAILHSMNMRESQAEKERERQQERLERLRRQKRSLMEDRTQQALKLLEKALEMDKVLAQDKERQELQLRSKLDEMKRRKGEKKDAEFVEIIDLKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U773</accession>
    <name>A0A433U773_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_002518</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000049">
        <property type="protein sequence ID" value="RUS89700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U773"/>
    <dbReference type="STRING" id="188477.A0A433U773"/>
    <dbReference type="OrthoDB" id="2101615at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="49"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="223"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS89700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="265" mass="28048" checksum="3CF6F4396E1689C7" modified="2019-05-08" version="1" fragment="single">MDGLSSGQAGEALGSGIPGGVDQVAQFTKFEHATVGSLYMLFCVLGVTSNLLTALTFYKDARLLPGSKPWLHILLALANMAVVCPSPLPASSSFSGRWLYGPVLCQLYAFEGMFAGIVAISAVIVLCMERYTVLSSAKPKDNSMFYVWSVLFALGNGFFWAVMPLLGWSRYDIEHTGISCALDWKNPDESYVSYMVTMEIFSFFIPLVAAAVCLYSACSQTGEKGAAPGTAAAGSGSGAGSKPGSSDGQEVNQVSSGFTESQLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UAB1</accession>
    <name>A0A433UAB1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_001545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000026">
        <property type="protein sequence ID" value="RUS90741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UAB1"/>
    <dbReference type="STRING" id="188477.A0A433UAB1"/>
    <dbReference type="OrthoDB" id="6141890at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056264">
        <property type="entry name" value="R2_ABCA1-4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF250">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23321">
        <property type="entry name" value="R1_ABCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="9"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="ABCA1-4-like C-terminal R2 regulatory" evidence="2">
        <location>
            <begin position="179"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS90741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="287" mass="31680" checksum="18E3F3475FF92C28" modified="2019-05-08" version="1">MTGDVLLNAGNAYIMGYDVINNLRKAQAHVGYCPQFGALIPEMTGEETLFLYGRLRGIPEDLIAGNVEELIKTFVFAHEGHLKCGNYSGGTKRKLNSAIAVIGSPPVLLLDEPSWGMDAHAKRQLWDVLMKLRDRGHTMVLTSHSMEEVEALCTRMTIMVNGRLVCLGSGQHLKSKFSRGYTFIVQLASQEDHSPAPADPVKDYIMGAVDGCELFEEYQGYLHFNAPHKVGQLAELFSLLERGKETLPIADYSVQQTSLEQVFLSFTKLQAAPTLIESKCPALPFCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UE52</accession>
    <name>A0A433UE52_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Arginase</fullName>
            <ecNumber evidence="2 12">3.5.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_000093</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>L-arginine + H2O = urea + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:20569"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="EC" id="3.5.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="12">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the arginase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.1" evidence="2 12"/>
    <dbReference type="EMBL" id="RQTK01000002">
        <property type="protein sequence ID" value="RUS92069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UE52"/>
    <dbReference type="STRING" id="188477.A0A433UE52"/>
    <dbReference type="OrthoDB" id="9992747at2759"/>
    <dbReference type="UniPathway" id="UPA00158">
        <property type="reaction ID" value="UER00270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004053">
        <property type="term" value="F:arginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09989">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000012">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014033">
        <property type="entry name" value="Arginase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01229">
        <property type="entry name" value="rocF_arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782:SF3">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0056">Arginine metabolism</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 12" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0835">Urea cycle</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS92069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="390" mass="42928" checksum="E1512F994EA0A562" modified="2019-05-08" version="1">MIGMSLGILNRLLLRTSPPLDINASSVILFAKERLWRLSRLLESDDKRKFRHKVLRRPPTQNIGIIGAPLVYGQPSIDPIFPFSQLNLLQPLQGACAAPDLLRGLRLAEVLKSKGANVKDYGNLEFRAVPNDFAVVLGCNYARTVGRANKQIQDEVSNILKNGESVLVLGGDHSVGLGSVSGHAKIRQDMALLWVDAHPDINTPLTSTSGNLHGMPVSFLVKELPHLSPRVPGLEWVEPCISSRNIAYIGLRSVDLQEKMFLRTLGICNFTMEDIKELGIDTAVTNALDRIDPEGKRSIHLSFDVDALDPLIIPATGTPVPNGLDFRQALTIARIVYNTRRMSVMDVVELNPLLSTPSAAIRSAQVTVEIIARAFTGKRMRYPSIRDVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UEL1</accession>
    <name>A0A433UEL1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_000081</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000001">
        <property type="protein sequence ID" value="RUS92228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UEL1"/>
    <dbReference type="STRING" id="188477.A0A433UEL1"/>
    <dbReference type="OrthoDB" id="6092864at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000095">
        <property type="entry name" value="B(0,+)-type amino acid transporter 1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF531">
        <property type="entry name" value="LARGE NEUTRAL AMINO ACIDS TRANSPORTER SMALL SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS92228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="28651" checksum="B8AB3A9D91B6F80A" modified="2019-05-08" version="1" fragment="single">NYLNFVIEELKDPYKNLPKAIWISIILVTCVYVFTNIAYFTTVSPEEIMGGAAVAVMFSKRLFGVMWWCMPVFVSLSTFGGVNGILFTTSRLFYVGGREGHMPQILSMVQIQRLTPMPAVLFMGLLSLLYLASSDIYALINYVGFATWLSIGMAIVVLLYLRWTRPDMPRPIKVHIVWPIIYTIVTVYLVILPLYASPTETGIGLMIICTGIPVYVIFVAWKSKPRAFTDFMDKMTATLQRFFMVVPEQKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z422</accession>
    <name>A0A3S0Z422_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_023342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001940">
        <property type="protein sequence ID" value="RUS68896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z422"/>
    <dbReference type="OrthoDB" id="4525710at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS68896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="202" mass="22913" checksum="D3F06BC00977D3F6" modified="2019-04-10" version="1">MESVRLTIRVNISSKSFFFNTFSWIALLFMVDRLANPLSRDAILDSMVPSLSSNRFNSSKLVLESCASLSMADRLEPVKSFCKSANPFSRDAILYSMVPSLSSNRFNNSSEVLLNSCASLSMADRLEPVKSFRKPANPFSRDSILASNRSSFISIKEVLLESCAVGTLRPCFCTRPVENHDCKKTLSFYLFFFHYCYRTNHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z6D9</accession>
    <name>A0A3S0Z6D9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glycerophosphocholine cholinephosphodiesterase</fullName>
            <ecNumber evidence="4">3.1.4.38</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Choline-specific glycerophosphodiester phosphodiesterase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Ectonucleotide pyrophosphatase/phosphodiesterase family member 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="33" type="ORF">EGW08_020553</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="33 34" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="33">EC2010</strain>
            <tissue evidence="33">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41003"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:34071"/>
            <dbReference type="ChEBI" id="CHEBI:74344"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:41004"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O = 1-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41115"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28733"/>
            <dbReference type="ChEBI" id="CHEBI:75561"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:41116"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(9Z-octadecenoyl)-sn-glycerol + phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41091"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28610"/>
            <dbReference type="ChEBI" id="CHEBI:75757"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:41092"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>1-dodecanoyl-sn-glycero-3-phosphocholine + H2O = 1-dodecanoyl-sn-glycerol + phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41127"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:74966"/>
            <dbReference type="ChEBI" id="CHEBI:75529"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:41128"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycerol + phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41119"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:75542"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:41120"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1-tetradecanoyl-sn-glycerol + phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40999"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64489"/>
            <dbReference type="ChEBI" id="CHEBI:75536"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:41000"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycerol + phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36083"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15850"/>
            <dbReference type="ChEBI" id="CHEBI:30909"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:36084"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycerol + phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="ChEBI" id="CHEBI:64683"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:44721"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>glycero-2-phosphocholine + H2O = phosphocholine + glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:144950"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:61685"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>sn-glycerol 3-phosphocholine + H2O = phosphocholine + glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19545"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
            <dbReference type="EC" id="3.1.4.38"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:19546"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>sphing-4-enine-phosphocholine + H2O = sphing-4-enine + phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41095"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="ChEBI" id="CHEBI:58906"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:41096"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="33">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.38" evidence="4"/>
    <dbReference type="EMBL" id="RQTK01001175">
        <property type="protein sequence ID" value="RUS71680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z6D9"/>
    <dbReference type="STRING" id="188477.A0A3S0Z6D9"/>
    <dbReference type="OrthoDB" id="415411at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047390">
        <property type="term" value="F:glycerophosphocholine cholinephosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF66">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE CHOLINEPHOSPHODIESTERASE ENPP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="17" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14 32" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="32" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="32" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00032556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00046203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00047600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00047779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00048209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00048703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00049092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00049320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="EMBL" id="RUS71680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="234" mass="25863" checksum="A90AAFE0F746F225" modified="2019-04-10" version="1">MALQDIDTEVGKLLDRMEALDDDEKFNLVIFSDHGMTTIDPARTINITDALNSEPGLYTTIMEGTALVSIYTPNKQAEDKVFTLLKDMSPHMHVYRQEDIPARFYYKDGPFVSSITCIADLGWTILQPLKVDFPTKGATKMVGYHGYDNGEVDMRGIFYAYGPYFKPGSRVDHIQAIDPYSVMCNILELTPSANNGSLAVFEPLKAVSGGNTVFASILSVWFSGVVGLLAWRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z880</accession>
    <name>A0A3S0Z880_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_020644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001190">
        <property type="protein sequence ID" value="RUS71600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z880"/>
    <dbReference type="OrthoDB" id="6153830at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS71600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="39418" checksum="9828FF4F97F0EEFD" modified="2019-04-10" version="1">MAEDNTQSPLATETDYSFVNYERLNGFCYLTQAVAALVLNILVVATVLKSQRIRKTPKYWLVLIVSTAYLIQAAFSNPQMIVVWFIGQDAHSCSVWVVAVAYNTYVCVGITCWCSFLINMDYFLCLMSVRYRRRQRASVISCMMFLSIVILIASMIAITIVFGSTTKPFNKATCHYSISNILVGEALLKYTVYFPLIGSIVFILLGVCCRKEGSMVSLLHPDQLNLTASLNAQGYGGSSRLPPLDHACVLLILILSYIPATLVSQLAASGRFSPQEYGENPTYLHITTTAVVMRDNAGYLVALSWFCFSDMRATFMQLPCFRRKSQPSDSAFAESSEFRIYDTYPYCSTQEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZBF5</accession>
    <name>A0A3S0ZBF5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3'-5' exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_021147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001275">
        <property type="protein sequence ID" value="RUS71086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZBF5"/>
    <dbReference type="STRING" id="188477.A0A3S0ZBF5"/>
    <dbReference type="OrthoDB" id="26838at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990923">
        <property type="term" value="C:PET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034587">
        <property type="term" value="P:piRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052144">
        <property type="entry name" value="piRNA_biogenesis_EXD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46628">
        <property type="entry name" value="PIRNA BIOGENESIS PROTEIN EXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46628:SF1">
        <property type="entry name" value="PIRNA BIOGENESIS PROTEIN EXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="2">
        <location>
            <begin position="84"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS71086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="483" mass="54477" checksum="2F36F99C44FB9242" modified="2019-04-10" version="1">MNGQAFGDIAEEKPSTFTLSAAMEAYKREEGSMQIKPTEELGMLQQERLTDAVDFIPSANSNNDDNFEDFYETQNYTLICRISEKFYESIKSIMYHHVVGVAFEGQNLGRTGVLSLVQVATGSEIIVFDMVRLGDEAFKAGLQCLFESEDVIHDCRWVADLLRFQYDITMANIFDTQVANAFVHRIFNEGKWPKHVQSLPDCLTSYLNLQRHEVHSPHISEENEIGWLERPLPPELLDLATKNAVHLLRLHRVLLEEMLSEFKAAVEIYLNLTSGGVEDLKKHQGHSPSYFKQTKILNIFSSRGATPPRPTFSSTKVLEISPAYDNMGIAVVESSNEKTDTGYETIERMAILSPCCSSRLEKEQIKLVHLNQQEDESSSANSTSKKYLDHQEQSIPNVMKYPLLPTHDHSQKEDISQAKAVHPGLASAYTKNSQPFSQNSKTIPGSDGILSLRSSTPAEMQETCRRKMIEESQCSTSKKLWGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-05-03" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZEQ3</accession>
    <name>A0A3S0ZEQ3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_018955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000955">
        <property type="protein sequence ID" value="RUS73282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZEQ3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS73282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="129" mass="14315" checksum="232FEEDC1CB49020" modified="2019-04-10" version="1" fragment="single">PGQEADEFGGVLPEQFLTLLLDDLLAELLEPRLLLALACLGLTLPGKLRAPVLHEALHGARVFLLLHAALLGVHLLDAVYSEHHPRGTHLLPELVLLLFLGLHPQRLVVHLLRVRRLHLDLLPDLPLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZHE0</accession>
    <name>A0A3S0ZHE0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_014573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000561">
        <property type="protein sequence ID" value="RUS77676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZHE0"/>
    <dbReference type="OrthoDB" id="5945439at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS77676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="108" mass="12774" checksum="DDBD20C135D874B9" modified="2019-04-10" version="1">MSASQEELRLGEQRETWCAVERMKEEAWCRKQRGHIQRYKDEMDSDVFHRTGSNEVVEERCSFAPDKPLHREQRHFPKVDNDRPAPTLGGPDMLQRMQAFKAHPTNHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZMB4</accession>
    <name>A0A3S0ZMB4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_013964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000521">
        <property type="protein sequence ID" value="RUS78273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZMB4"/>
    <dbReference type="OrthoDB" id="10547782at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS78273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="125" mass="14183" checksum="28DA04D701AD99D9" modified="2019-04-10" version="1">MEIVIQYFVKGCTLEIAHYLESHEESLWKHPLKTLAESVADALSLARPRHVDESFLTKALSDRLGLRFATLYNIALENVAMLQSEIKTYLTEVTHLLAPVATNIITKTSANYQRLHSIILQVILH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZNQ8</accession>
    <name>A0A3S0ZNQ8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein sleepless</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_013033</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000464">
        <property type="protein sequence ID" value="RUS79204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZNQ8"/>
    <dbReference type="OrthoDB" id="6139125at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032222">
        <property type="term" value="P:regulation of synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030431">
        <property type="term" value="P:sleep"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031424">
        <property type="entry name" value="QVR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050975">
        <property type="entry name" value="Sleep_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562">
        <property type="entry name" value="ATILLA, ISOFORM B-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562:SF28">
        <property type="entry name" value="PROTEIN QUIVER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17064">
        <property type="entry name" value="QVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5021488662" description="Protein sleepless" evidence="3">
        <location>
            <begin position="23"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS79204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="134" mass="15037" checksum="FAB55CB695B25AC1" modified="2019-04-10" version="1">MNRHNFRGAIFLLLISLEYSHATWCFICHTDTDSGCGDNFSISTSDSEKRQECTGSCVKRRGKRERGSVSRTEVQRSCRSYGSEGCYTEEFNGITQYTCLCNSDFCNGSPTQFQQSFSLVTTLTVAVAAIKNYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZNV8</accession>
    <name>A0A3S0ZNV8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein YIF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_020418</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Has a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Golgi apparatus membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the YIF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001154">
        <property type="protein sequence ID" value="RUS71811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZNV8"/>
    <dbReference type="STRING" id="188477.A0A3S0ZNV8"/>
    <dbReference type="OrthoDB" id="337750at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005578">
        <property type="entry name" value="Yif1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083">
        <property type="entry name" value="YIP1 INTERACTING FACTOR HOMOLOG YIF1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083:SF0">
        <property type="entry name" value="YIP1D-INTERACTING FACTOR 1, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03878">
        <property type="entry name" value="YIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS71811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="329" mass="37101" checksum="79D7B1897FE4B4E1" modified="2019-04-10" version="1">MDVPSEYRAAPTKPSQKRRPKGHKGGQPAPQMAPPQQPYNDFSMHNQQQQNYMQNFGQPDMFFSGYNTGNPGGAPGPEQQFAQQYLNNPMANMAMQYGSSLAGQGKDIVDKNIEKVMSSSKVKYYFAVDTAYVGKKLGLLFFPFTHSDWSIRYNQDEPIAPRYEINAPDLYIPSMAFVTYLLVAGMVLGIQDRFTPEQLGTQASSALGWLIIEMLAFSLSLYVMNLKSGIKYLDIIAYCGYKFVGMTVSLLAGAMSSNTVYYCVLLWFCLALVFFLMRTLRVQIVPQSEVDDGHTIGTKRSLYFILSVSLVQPLLMWWLSSSIMIYRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-05-03" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZQC8</accession>
    <name>A0A3S0ZQC8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_019412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001013">
        <property type="protein sequence ID" value="RUS72819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZQC8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS72819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="118" mass="13344" checksum="AE86F822AD2A58F4" modified="2019-04-10" version="1">MMPMAPRRALSTSATMPLASTTYHHRRCCHWNTTSTTSNLTASAPENRNSTGTTLRDEESPGYQSHKTPLYSLFNFLVGEMKVAFAKCIVIDMLTFDLYTSVNFLGGYLFNCYRSRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZT91</accession>
    <name>A0A3S0ZT91_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="12">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EGW08_006951</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">EC2010</strain>
            <tissue evidence="15">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="12"/>
    <dbReference type="EMBL" id="RQTK01000175">
        <property type="protein sequence ID" value="RUS85304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZT91"/>
    <dbReference type="STRING" id="188477.A0A3S0ZT91"/>
    <dbReference type="OrthoDB" id="1911748at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000015">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043323">
        <property type="entry name" value="PIN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45995">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13616">
        <property type="entry name" value="Rotamase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 11 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 12" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PpiC" evidence="14">
        <location>
            <begin position="41"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RUS85304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="137" mass="13957" checksum="A12262E5481FC78D" modified="2019-04-10" version="1">MPKGKGGGGGGGAAKAGGGGAKGKGKGAEGGGDDGKTAKGGTAVKVRHILCEKQSKALEAIEKLESGMKFNEVAAQYSEDKARSGGDLGWMTRGSMVGPFQEAAFALPNSTIDKPNYTNPPVKTKFGYHIIMVEGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZUY1</accession>
    <name>A0A3S0ZUY1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="12">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EGW08_004876</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">EC2010</strain>
            <tissue evidence="15">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="10 12">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="12">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="12"/>
    <dbReference type="EMBL" id="RQTK01000113">
        <property type="protein sequence ID" value="RUS87334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZUY1"/>
    <dbReference type="STRING" id="188477.A0A3S0ZUY1"/>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000025">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050151">
        <property type="entry name" value="Class-I_Pyr_Nuc-Dis_Oxidored"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912:SF151">
        <property type="entry name" value="DIHYDROLIPOYL DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912">
        <property type="entry name" value="DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 10 12" id="KW-0274">FAD</keyword>
    <keyword evidence="2 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 10 12" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 12" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="14">
        <location>
            <begin position="40"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="13">
        <location>
            <begin position="385"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="483"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="217"/>
            <end position="224"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="357"/>
            <end position="360"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="11">
        <location>
            <begin position="77"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RUS87334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="505" mass="53543" checksum="775A57CCD25F204B" modified="2019-04-10" version="1">MLASSLRISTVFRANGPIKNKSFAALYVSARNYAGGGDTDLVVIGSGPGGYVAAIKAAQLGLKTVCVERNPTFGGTCLNVGCIPSKSLLNNSHLYHMASGKDLASRGIEFTDVKLNLDKMMDQKRGAVKALTAGIAGLFKKNGITSIQGFGRISGPNEVTVTKDDGTQEKVSTKNILIAVGSEVTPFPGIEVDEKQIVSSTGALELEAVPEHLVLIGAGVIGVELGSVWQRLGAKVTCVEFLGHVGGMGIDMEISKTFQRTLSKQGLKFKLNTKVVSATRDGSKIKVSVEGVKDGKKEDIDCDTVLVCVGRRPYTQDIGLETVGLQLDGKGRVPVNSRFQTSVPSIYAIGDCIDGPMLAHKAEDEGIICVEGICGGAVHIDYNCVPSVIYTHPEVAWVGKTEEMLKEEGIEYKVGSFPLAANSRAKCNNDTDGLVKILSDKKTDRMLGAHIIASCAGELINEAALAMEYGASCEDVARVCHAHPTVSEAFREANVAAYFGKPINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZXY5</accession>
    <name>A0A3S0ZXY5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA (guanine-9-)-methyltransferase domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_006443</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000159">
        <property type="protein sequence ID" value="RUS85814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZXY5"/>
    <dbReference type="STRING" id="188477.A0A3S0ZXY5"/>
    <dbReference type="OrthoDB" id="6134801at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097745">
        <property type="term" value="P:mitochondrial tRNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070131">
        <property type="term" value="P:positive regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18102">
        <property type="entry name" value="Trm10_MRRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028564">
        <property type="entry name" value="MT_TRM10-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038459">
        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025812">
        <property type="entry name" value="Trm10_C_MTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007356">
        <property type="entry name" value="tRNA_m1G_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563">
        <property type="entry name" value="TRNA (GUANINE-9-) METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563:SF5">
        <property type="entry name" value="TRNA METHYLTRANSFERASE 10 HOMOLOG C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51675">
        <property type="entry name" value="SAM_MT_TRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent MTase TRM10-type" evidence="10">
        <location>
            <begin position="203"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS85814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="398" mass="45806" checksum="E35E767FF7514169" modified="2019-04-10" version="1">MLPTVSRLLSKRFKLSGRYFCSKSKIKISFPWFAREICNGLTYCKHAQLYSTLKQSVVHDLCADIQLSELKAKHKCEAESFSLADAVQAEVDQRLNQAIQQLDEQQLRFLKIVQLEHSFLFSEGYSIPAPEDLTNRNWLEAMTMSSMDERLAYYCNLEQIAKKRKIEREKRMEQVGAESDTDGENSESIFLQSLTSLQKERLMNYRLASAMLHSGYLVIDLGFDEHQLSIDIDPLVSQIWNLYLLNGANPDPFHLIFTNCDFTGPVYRHLLLNCMVNVDFVMATFTEKSHTDILPSENLVYLSSQSKEHLTVFDTNKTYILGAYHDPLVRKKLSFAKARQENLLCQKLPIDQHVKWAHQAHKDLDLDSMVGILLSVRDDGQWKKAFVSVVPMLVNQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZYA8</accession>
    <name>A0A3S0ZYA8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_003214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000068">
        <property type="protein sequence ID" value="RUS89043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZYA8"/>
    <dbReference type="STRING" id="188477.A0A3S0ZYA8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS89043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="207" mass="25288" checksum="1B4F9559B112DECF" modified="2019-04-10" version="1">MDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDGWMDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZZR1</accession>
    <name>A0A3S0ZZR1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_001486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000025">
        <property type="protein sequence ID" value="RUS90775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZZR1"/>
    <dbReference type="STRING" id="188477.A0A3S0ZZR1"/>
    <dbReference type="OrthoDB" id="10005859at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026702">
        <property type="entry name" value="CCDC83"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21468:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21468">
        <property type="entry name" value="HSD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS90775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="140" mass="15926" checksum="9B77FA21866DBD7A" modified="2019-04-10" version="1">MDLAKITVPTEESIEQQVLKISTDRPKSATQKAVEDKVFSLISYRPSLEDTGEEEEPAPSEADSGSDFYENYFFEEENFEDYLKLGPLELKLLSVTGQQMPIHEMEEPSQEEVESKAWNPDEWPVTCGMLKGPLMFNVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-05-03" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A0Z0</accession>
    <name>A0A3S1A0Z0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_004314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000097">
        <property type="protein sequence ID" value="RUS87898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A0Z0"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS87898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="170" mass="18983" checksum="EC95201F3F1C7EA3" modified="2019-04-10" version="1" fragment="single">STSFTLGVFFKCVGDCDGPVTQVLIIHGLNGCIGSLEACKVDKCIAFRVSRVSVSHNLRKKKSTCLKYYSKSTERIIQKFLIHLWIQVTNEDVGTDVLPFGVCRGLMAYLVDPDRLAVELDHVHDFDGVVCILLTHELDKTVALVSLGNAVFGHVDIDWRKEKKKEIGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A184</accession>
    <name>A0A3S1A184_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HOOK N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_000995</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000015">
        <property type="protein sequence ID" value="RUS91283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A184"/>
    <dbReference type="STRING" id="188477.A0A3S1A184"/>
    <dbReference type="OrthoDB" id="10254988at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030705">
        <property type="term" value="P:cytoskeleton-dependent intracellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22223">
        <property type="entry name" value="HkD_HkRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043936">
        <property type="entry name" value="HOOK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947:SF28">
        <property type="entry name" value="GIRDIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947">
        <property type="entry name" value="HOOK PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19047">
        <property type="entry name" value="HOOK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116907">
        <property type="entry name" value="Hook domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HOOK N-terminal" evidence="6">
        <location>
            <begin position="12"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1167"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="233"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="439"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1023"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1107"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1173"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS91283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1186" mass="137722" checksum="52570B3238FD21DE" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A4B6</accession>
    <name>A0A3S1A4B6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_009787</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000286">
        <property type="protein sequence ID" value="RUS82441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A4B6"/>
    <dbReference type="STRING" id="188477.A0A3S1A4B6"/>
    <dbReference type="OrthoDB" id="6273859at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052065">
        <property type="entry name" value="Compl_asym_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906:SF43">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="392"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS82441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="50306" checksum="B9121592216E8C03" modified="2019-04-10" version="1">MGCQVTLFYYSSPTKPAAKGGDSMVNLIPVQLFSRLVTFSVADVKIGGDEVFLILILPHSDFSIVMCHGSTCGRWTEVDQSGILPHWKVFFKTFSAKEAYTVFHRNMTRFGLYVFKPALGKGAISAAGFDLPTQDCLTTIMQIDDNMDNDCDGNIDEEIENEEDDDGDGRVDEDLRIPSRSVVIHGVWSVWSPWDCWATCGGAARYRRYRYCDRPPPSAQGRDCPGDFVEYSNRICDYTNVPCFKDCPFTKWGPRCDEDCPTGCLHRTCDYDTGHCMGCRPGRMGDQCEMECPRFHFGAGCNQSCLEFCIDHCDPETGECDFDLKLMHVLVSILTMGIIPGVLFYAGIVLCKKQDPDLRALKDTLHSVDEQTNEVKLFTKARELNHKELRRRLKKKPSNWSAQIPAPVPVPEPEKPVGQKPGPDASFIKMAASAVEMVVKLPKGTSAGSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A6B1</accession>
    <name>A0A3S1A6B1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_008378</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000227">
        <property type="protein sequence ID" value="RUS83837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A6B1"/>
    <dbReference type="OrthoDB" id="6152037at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="421"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS83837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="525" mass="55332" checksum="C0F824204E224700" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AH65</accession>
    <name>A0A3S1AH65_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UFSP1/2/DUB catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_000243</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C78 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000003">
        <property type="protein sequence ID" value="RUS92030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AH65"/>
    <dbReference type="STRING" id="188477.A0A3S1AH65"/>
    <dbReference type="OrthoDB" id="417506at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071567">
        <property type="term" value="F:deUFMylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012462">
        <property type="entry name" value="UFSP1/2_DUB_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48153:SF3">
        <property type="entry name" value="INACTIVE UFM1-SPECIFIC PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48153">
        <property type="entry name" value="UFM1-SPECIFIC PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07910">
        <property type="entry name" value="Peptidase_C78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UFSP1/2/DUB catalytic" evidence="3">
        <location>
            <begin position="30"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS92030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="230" mass="25886" checksum="9DC33F8E5457F13B" modified="2019-04-10" version="1">MEDKKLDKEKHGTLHLLTNVHEGLPLRPKSTFCQGLYSYYHYFCDGVADMGWGCGYRTLQTLCSWVHHQLQTASLERNSKVLSVPGIRDIQSALVEMGDKPQTFAQSRQWIGSFEVCLCLDFFYDVPCKIIHVTKGCELEQHLPELSAHFQSWGCPVMMGGETDNSSKGVMGVCEDPPALLVVDPHYVKDEKTPATCASLQEAGWVRWIEICELHADSFYNLCLPRLAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AV17</accession>
    <name>A0A3S1AV17_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RanBD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_023172</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001847">
        <property type="protein sequence ID" value="RUS69069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AV17"/>
    <dbReference type="STRING" id="188477.A0A3S1AV17"/>
    <dbReference type="OrthoDB" id="2357150at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13179">
        <property type="entry name" value="RanBD_RanBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000136">
        <property type="entry name" value="Ran-specific GTPase-activating protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045256">
        <property type="entry name" value="RanBP1_RanBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF94">
        <property type="entry name" value="RAN BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="2">
        <location>
            <begin position="21"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS69069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="212" mass="24051" checksum="E0016D36DECC7400" modified="2019-04-10" version="1" fragment="single">MAGTDEKEHEAEVEPESPDVHFEPIVKLALVDNKTLEEDEDVLLSLRARLFRYDSDAEPMEWKERGTGDCKILQHKTTGYIRILMRRDKTLKICANHYIYPTMELKPNCGSERAWVWTTQADYADEEIKKEVLAIRFANAENAQKFKSVFDNSATVMKELLEIKGKSVDVDEANKSKEQSSDESQQDASIASTAGDKSTDSLSEKLEDLKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AYS8</accession>
    <name>A0A3S1AYS8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Interferon-induced transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_021531</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD225/Dispanin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001350">
        <property type="protein sequence ID" value="RUS70711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AYS8"/>
    <dbReference type="OrthoDB" id="6083617at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051423">
        <property type="entry name" value="CD225/Dispanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007593">
        <property type="entry name" value="CD225/Dispanin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14948:SF25">
        <property type="entry name" value="DUF4190 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14948">
        <property type="entry name" value="NG5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04505">
        <property type="entry name" value="CD225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS70711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="16787" checksum="3189BD802D7D33C7" modified="2019-04-10" version="1">MSHPATIDHQAVHINLTKHGTNPVVTSQPDSVQSPSVHYDAPTAMAIFTQSPTPVVAQKPDPKLKPKDFVMTSCFVVFACNFIFGLLGYHFGVKSNYAWQLGDLAMAKHHAKKALIFVIIGVFVGILTYVLAFVLYFVVFDKPSHDIENRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AZM5</accession>
    <name>A0A3S1AZM5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_019831</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001071">
        <property type="protein sequence ID" value="RUS72413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AZM5"/>
    <dbReference type="STRING" id="188477.A0A3S1AZM5"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005283">
        <property type="term" value="F:amino acid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089718">
        <property type="term" value="P:amino acid import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF321">
        <property type="entry name" value="SODIUM-DEPENDENT NUTRIENT AMINO ACID TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS72413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="34529" checksum="0F430EFEC05C8902" modified="2019-04-10" version="1" fragment="single">MVIISGIVCVYYNIIIAWTFYYVYSTMQSTLPWSRCDNSWNTPSCIGPGSILNETEQDKKNGTQSSVEFWERNVLNRSKGLEHFGSVRWPLFICLWLSWFAVFLCLCKGVKSSGKVVYVTATFPYLVLSILLIKCAMLPGAKEGLKWYLIPQWGKLASVKVWGDAALQIFYSVGMAWGSLITLASYNKFNNNVFRDAMIVPSVNCFTSVFAGLVIFSVLGFMSHTTGKPIEDVVTQGPGLIFIVYPEAVTKMPVSHFWAVMFFLMILTIGMDSQFGMFETMTSAFVDEYPKLLRKHKLAFTAFMCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B0J3</accession>
    <name>A0A3S1B0J3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc finger double-stranded RNA binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_020334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001142">
        <property type="protein sequence ID" value="RUS71905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B0J3"/>
    <dbReference type="STRING" id="188477.A0A3S1B0J3"/>
    <dbReference type="OrthoDB" id="775260at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01715">
        <property type="entry name" value="IPPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS71905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="23555" checksum="786E2F4A2ADB11AC" modified="2019-04-10" version="1">MLQMLGFKEFTDYLQLSPQGRMSKEGEKLFKQGVEDLKQATRRYAKQQVRWITNRFCARPGPSVPPVYSVDSTDLGNWDQAVAQAIQVVRAFTQGEVPAMAPEPTQRKVDSTVVREVCDVCGGRIFLHQHEWTGHLKSKKHRHNVKVAKERGKLSSILSARETQLKEKETSSQQQTSQSENSTCDSHGMVQLDNAVGTPVDGDCLLTPGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B0N9</accession>
    <name>A0A3S1B0N9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_020213</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001126">
        <property type="protein sequence ID" value="RUS72029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B0N9"/>
    <dbReference type="OrthoDB" id="6140281at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050801">
        <property type="entry name" value="Ca-Dep_Lectins_ImmuneDev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801:SF63">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801">
        <property type="entry name" value="LITHOSTATHINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018640988" description="C-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="63"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS72029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="230" mass="26103" checksum="26848BD6C9558A31" modified="2019-04-10" version="1">MNLTVFLSVFIITLVCWSREGFCSSYKGNIAKQLKSIRTDLNKVTRELNRQRQISCPGGYVRFGYSCFRFFMDEKHKSVWADAEQTCLSDGGHLVSVEHKRYYKFIKKYLKRNFKSYYTSGAGALLYTGLIYTNHHAKLPFDPLGPVNTTVRDADGFRWTATGLAPGEGTKSKWKPNIPTSNIAPGAKYVSCVVLDFNPKSPAGLLVWRAHSCSSEKLRFICEVRLPHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B1I2</accession>
    <name>A0A3S1B1I2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CobW C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_014636</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000568">
        <property type="protein sequence ID" value="RUS77597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B1I2"/>
    <dbReference type="STRING" id="188477.A0A3S1B1I2"/>
    <dbReference type="OrthoDB" id="258627at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03112">
        <property type="entry name" value="CobW-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="entry name" value="CobW-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051316">
        <property type="entry name" value="Zinc-reg_GTPase_activator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748">
        <property type="entry name" value="COBW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748:SF31">
        <property type="entry name" value="ZINC-REGULATED GTPASE METALLOPROTEIN ACTIVATOR 1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00833">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90002">
        <property type="entry name" value="Hypothetical protein YjiA, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CobW C-terminal" evidence="8">
        <location>
            <begin position="255"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS77597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="361" mass="40179" checksum="6FD448B1DFF0329C" modified="2019-04-10" version="1">MNEDSDDDVPELVAANISKVPVTVITGFLGSGKTTLLNFILTEQHGKKIAVILNEFGEGDSIEKSMSVGEEGELFEEWLELRNGCLCCSVKDNGVKAIENLMQKKGKFDYILLETTGLADPGPIASIFWLDEELCSDVYLDGIIVMVDAKFCERHIDEKKEDGSVNECQKQIALGDVIIVNKTDLVSTEQLEGLRDRIKSVNNFAKIVETSHSKINPESILDINAYGLSGDMKIEDIFTQRGFSKENKHAIDQSVGTITLQLPGNVDKTALDDFLQTLLWEKTVKDATGNTIEVLRLKGMMSIVGSDHRLVVQAVEELYDSHTTTLWEDDLSRISTVVFIGRNLDKDILQTHLLKLTELKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B1V8</accession>
    <name>A0A3S1B1V8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_014375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000546">
        <property type="protein sequence ID" value="RUS77862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B1V8"/>
    <dbReference type="OrthoDB" id="354351at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS77862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="107" mass="12033" checksum="9699C21BE6DFEE23" modified="2019-04-10" version="1">MIIIIIIIIIIIIIIIIIIIIFIIIFSQVNKLKLDEATENVVHKTNQSVVCTFQNGKLELQMTPLDVAWSKTQGVEYSLNDRGELMVVYAAGSNVCRRCFVKVAQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B2L4</accession>
    <name>A0A3S1B2L4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucosamine 6-phosphate N-acetyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_021870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 1">
            <text>D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="2.3.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family. GNA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.4" evidence="1"/>
    <dbReference type="EMBL" id="RQTK01001425">
        <property type="protein sequence ID" value="RUS70368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B2L4"/>
    <dbReference type="STRING" id="188477.A0A3S1B2L4"/>
    <dbReference type="OrthoDB" id="10039976at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355:SF11">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS70368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="142" mass="15939" checksum="448B95A7E2EFAF55" modified="2019-04-10" version="1">MAENGFQSACTYIYDPAILLRLTSSTFQAEYKNGVKPLNPGENLKLRPLCLEDYDKGYLQLLSQLTSVGDVTREQFEDRFNKMKACDDTYYITVIEDLTSKQVIGSATLVKEQKFIHGSTARARVEDVVVSDSCRGKQLGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B7X5</accession>
    <name>A0A3S1B7X5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">KIAA0895</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_014079</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000529">
        <property type="protein sequence ID" value="RUS78150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B7X5"/>
    <dbReference type="OrthoDB" id="449345at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012548">
        <property type="entry name" value="MATCAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31817">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31817:SF0">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_67, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08014">
        <property type="entry name" value="MATCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01154">
        <property type="entry name" value="DUF1704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS78150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="474" mass="55340" checksum="A48E9022AD8A352C" modified="2019-04-10" version="1">MFYRRYRHSVSLMGRPESITCNFPSSASSSAQNATLLNMQEYQSGRNYASYGALTDRPHKKRKKRSVAKHQKSSDIFQFQRSSSSLSDSFLPIKQLGTKTKRLPRLMSPSRLDELAAPSHRQHMLTMSLIVKNNEKKKKLPLLVAIKPENERSEKERFMRASFNYNPYFVYKGVADDDVMDKFRDPSDKYLSQAILIMERAIRYFGSYEHFEEITGGKILNRSQIYSLIKRYISREELEEEVVINLSEDLLSRGSMTRAKGKSVLSVRSVNLREHWAEGLLRHELGTHYLRSCNNRHHPWNSNRVRRDLGMGPINPTEEGLASLHSVLFREKPFLWRAALLYYTTYMASKLSFKELFSDLERFVHSPNVRWDYCLRAKRGQVDTSRPGSFCKDQVYLEGLLQLLKRRRVLDFHLLVRLGKVSFEDVDRECVTEIAQLTNTRIPWFMEDLTLYHRQLDHIAYTNGLTNDILSTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B9R5</accession>
    <name>A0A3S1B9R5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mos1 transposase HTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_013736</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000506">
        <property type="protein sequence ID" value="RUS78489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B9R5"/>
    <dbReference type="STRING" id="188477.A0A3S1B9R5"/>
    <dbReference type="OrthoDB" id="10018757at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001888">
        <property type="entry name" value="Transposase_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF1">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01359">
        <property type="entry name" value="Transposase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS78489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="43570" checksum="CF0AEB1751B365C9" modified="2019-04-10" version="1">MVEVYAEKCPNYSTVTHWVRKFKSGFLSVMDEPREGRPTSVVTEKNVSTVEGLVKQDRRITVKQLASETRISVGSVEKILHDHLNLNKVSARWVPRLLTADQKKERADCCKHLLWLEANDDLFFQKIVTMDETWIYQFDPEPKNASMQWKRPSSPPPKKAKVTQSSGKVMLSCFWDCEGIIMTDYMEKGKTITREYYSGLLKRLRSELVRRRRGKLRNGVLLLHDNAPAHRARQAVETADQCNYEILPHPPYSPDLAPSDFCLFPNLKKSIKGRRFEDIEGAISAVEEWFQAQNDTFYSQGLLKVKDRWQKCTVCLGGPAWNRIARLDREYRNPAVGPSLASAAAAAASLLASRTFLFRHRNFREGKMVMPEPFPEASFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B9T5</accession>
    <name>A0A3S1B9T5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_013001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000463">
        <property type="protein sequence ID" value="RUS79216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B9T5"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS79216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="201" mass="22520" checksum="DD5E740B8AD24CE3" modified="2019-04-10" version="1" fragment="single">DSVSYSREGRDAHRGRTVFPETWKPVGRPAKVPSESPQNRRHVSAGRAVESVGRRSQQRPVTQHSMREYKLSTSAKTSKSSEQPRSKSVPPPKSSSTCKTITGKRDQYLYSSKTDENYRSTKPCSSAFLVTRERSIENPEDKYKQQRSKSQNGELEDEDATASKKAITNKKYISSTATKSDSNIKCTDQSQTSKQRSGGHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BCY8</accession>
    <name>A0A3S1BCY8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ZNF451 PIN-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_014469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000554">
        <property type="protein sequence ID" value="RUS77764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S1BCY8"/>
    <dbReference type="OrthoDB" id="6097353at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041192">
        <property type="entry name" value="PIN_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18479">
        <property type="entry name" value="PIN_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZNF451 PIN-like" evidence="2">
        <location>
            <begin position="1367"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="950"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1308"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="954"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="982"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1037"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1053"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1081"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1309"/>
            <end position="1336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS77764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1500" mass="166458" checksum="A4BFF8B441217383" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-05-03" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BDM3</accession>
    <name>A0A3S1BDM3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_011107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000354">
        <property type="protein sequence ID" value="RUS81121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BDM3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS81121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="111" mass="13727" checksum="05C9105212B1B37F" modified="2019-04-10" version="1" fragment="single">LFHAHQLLFHAHQLLFHAHQLLFHAHQLLFHAHQLLFHTHQLLFHTHQLLFHTHQLLNHFLLLLFHAHHLLNHFLSLLFYDHQLFFHYHQLLFHDHLLLNHWVVNEKLIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BE47</accession>
    <name>A0A3S1BE47_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NIPSNAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_013524</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NipSnap family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000494">
        <property type="protein sequence ID" value="RUS78703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BE47"/>
    <dbReference type="STRING" id="188477.A0A3S1BE47"/>
    <dbReference type="OrthoDB" id="10262843at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000003">
        <property type="entry name" value="Protein NipSnap homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012577">
        <property type="entry name" value="NIPSNAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051557">
        <property type="entry name" value="NipSnap_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017">
        <property type="entry name" value="NIPSNAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017:SF17">
        <property type="entry name" value="PROTEIN NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07978">
        <property type="entry name" value="NIPSNAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIPSNAP" evidence="2">
        <location>
            <begin position="83"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="NIPSNAP" evidence="2">
        <location>
            <begin position="195"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS78703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="294" mass="34226" checksum="BBF434A7EC28917B" modified="2019-04-10" version="1">MATLCKTLLCFGSRSTVSAVKRSLQSARTVQFGVRNVHATAALMREAPSDDDDQPRGWFSRLRKAAQPEQSHSMALSTKEQVYEIQFHSVKPECMEEYLKLYSQLQDLMRQKETGAELAASFTVEIGEQDEAIHIWQYPGGYPTLNHANTIYRTDSEFLDIRKQRNMMLRSRKNQILLAFSFWPTISPREGTNIYELRSYTLKPGTMYEWANCWARGIQHRRENNEPVAGYFTQLGQQFTVHHIWAYKDLQTRKETREAAWNRPGWDECVSYTVPLIRYMQSRILIPTPFSPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BG17</accession>
    <name>A0A3S1BG17_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SMB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_009431</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000270">
        <property type="protein sequence ID" value="RUS82811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BG17"/>
    <dbReference type="STRING" id="188477.A0A3S1BG17"/>
    <dbReference type="OrthoDB" id="6155123at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036024">
        <property type="entry name" value="Somatomedin_B-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001212">
        <property type="entry name" value="Somatomedin_B_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01033">
        <property type="entry name" value="Somatomedin_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90188">
        <property type="entry name" value="Somatomedin B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50958">
        <property type="entry name" value="SMB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMB" evidence="3">
        <location>
            <begin position="632"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="703"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS82811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1224" mass="136815" checksum="479D5054926FE3AB" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BGX5</accession>
    <name>A0A3S1BGX5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_008558</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">JanA and janB regulate somatic sex differentiation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the janus family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000234">
        <property type="protein sequence ID" value="RUS83710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BGX5"/>
    <dbReference type="STRING" id="188477.A0A3S1BGX5"/>
    <dbReference type="OrthoDB" id="10249612at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101006">
        <property type="term" value="F:protein histidine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007548">
        <property type="term" value="P:sex differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.20.20">
        <property type="entry name" value="Janus/Ocnus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007702">
        <property type="entry name" value="Janus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038596">
        <property type="entry name" value="Janus_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12258:SF5">
        <property type="entry name" value="BCDNA.GH02250-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12258">
        <property type="entry name" value="JANUS-A/JANUS-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05005">
        <property type="entry name" value="Ocnus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143724">
        <property type="entry name" value="PHP14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0726">Sexual differentiation</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR607702-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR607702-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS83710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="127" mass="13872" checksum="106702301DAF639A" modified="2019-04-10" version="1">MPGKVLEKNPVLAGVEEVAIDASGNFKYILCRVYKDGAKEDSKLIIRGTAQAEYHADIYDHLDSSLEDIGLTCECLGGGRIDHNAAAKSIEVYGLSQGYGKADHTIAVRLLREKYPDYTTISSSDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BIS8</accession>
    <name>A0A3S1BIS8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_010463</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000321">
        <property type="protein sequence ID" value="RUS81771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BIS8"/>
    <dbReference type="STRING" id="188477.A0A3S1BIS8"/>
    <dbReference type="OrthoDB" id="6161980at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050488">
        <property type="entry name" value="Ig_Fc_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11481:SF60">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11481">
        <property type="entry name" value="IMMUNOGLOBULIN FC RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="32"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="122"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS81771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="401" mass="44599" checksum="E6B14F3B88B8E2DF" modified="2019-04-10" version="1" fragment="single">TPADGGNYSCQYVSDDETSSTSEALELVVNRPDTPQFESSATVVGLEERVILSCLVSFGGSARVIYTFIQPNKALFTTKDRRITISRFGSSNIGEYKCKISILETESELSNAVWISLKPATPSLSTIRDNLFLNGSTVLFCSNSDTEPPEKQFIFMKNKEVVQEGRDHDVTIQDFSPGKEAQYTCYVEIRNAQNNGTIQSESSNAIQISFAWSSIILTSNLTEVTSGDTVKLTCGSAGLEILREYYFYKDNFLLAKKSTITSEVGIFLASFSKADQGNYSCRWNPVATGERPIWSNDVSLTCVSQFHICECHCPNHIVQVNITSEEVQKVVHELEKDLKMPKMNLSSTHRRKVSVADYNPYSTSVGYVAILMLVLVFGSIVLSDSRGFAMFVYKKVLCCQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BJU5</accession>
    <name>A0A3S1BJU5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small monomeric GTPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_006764</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000168">
        <property type="protein sequence ID" value="RUS85488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BJU5"/>
    <dbReference type="STRING" id="188477.A0A3S1BJU5"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00157">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002060">
        <property type="entry name" value="Rho family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS85488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="23928" checksum="52FC1FAF6C416EFB" modified="2019-04-10" version="1" fragment="single">MSVCNKPEKDLSYKMLNEKKTNVKCVIVGDAMVGKTSLARRLACLGFATDYNPTTFDNYVVTTSMGGKSYVLSLFDTAGQEEYIHLRALSYVNCDVFLLCFSVATPESLQQAYDKWLPELQRFSPGTPLVLVATQIDRRDDGPDVVAPSSVKLKLRAPFVSTKEGQQAAVKLQADCYVECSSLTEAGISRLREAAIEYGLRRPDPEEKKGCNCSCVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BKF9</accession>
    <name>A0A3S1BKF9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_022977</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001754">
        <property type="protein sequence ID" value="RUS69263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BKF9"/>
    <dbReference type="OrthoDB" id="2519255at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS69263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="158" mass="17730" checksum="BD80E7271CD28743" modified="2019-04-10" version="1" fragment="single">KRGARCNLLVEFIGQIFHQYRFSCLVSDLSGCITRLIVHDPKGMYSHPSLVPGESGISTLQACLRPGDFLLLLAVHWRQFTDGLPGIRINSLDSIYVINMADRKMPRNYRQRLEGIAQEESTKLRLQWNFGLMTMGVGGGPCPQMLPALSERGSQDDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BKI3</accession>
    <name>A0A3S1BKI3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_022938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001740">
        <property type="protein sequence ID" value="RUS69300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BKI3"/>
    <dbReference type="OrthoDB" id="6161176at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS69300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="140" mass="15162" checksum="90D5B819354A5C65" modified="2019-04-10" version="1">MSFLKFWSSKKSGSKKDDSDAKSGDASQEPDLEKRRLRHSLSISRSGRFKQRKRERSQILDRPEIFDCHDCPHGEVQTASSSSSSSLASQTQGESDSLRAAEKSSAGGHFISAAASSSPKFGCRSVAPPGGLRMGRPMLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BL20</accession>
    <name>A0A3S1BL20_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">IkappaB kinase</fullName>
            <ecNumber evidence="3">2.7.11.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EGW08_001434</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">EC2010</strain>
            <tissue evidence="15">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[I-kappa-B protein] + ATP = O-phospho-L-seryl-[I-kappa-B protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19073"/>
            <dbReference type="Rhea" id="RHEA-COMP:13698"/>
            <dbReference type="Rhea" id="RHEA-COMP:13699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.10" evidence="3"/>
    <dbReference type="EMBL" id="RQTK01000024">
        <property type="protein sequence ID" value="RUS90815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BL20"/>
    <dbReference type="STRING" id="188477.A0A3S1BL20"/>
    <dbReference type="OrthoDB" id="267381at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008385">
        <property type="term" value="C:IkappaB kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008384">
        <property type="term" value="F:IkappaB kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033209">
        <property type="term" value="P:tumor necrosis factor-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000147">
        <property type="entry name" value="Inhibitor of nuclear factor kappa-B kinase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041185">
        <property type="entry name" value="IKBKB_SDD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046375">
        <property type="entry name" value="IKBKB_SDD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051180">
        <property type="entry name" value="IKK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22969">
        <property type="entry name" value="IKB KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22969:SF17">
        <property type="entry name" value="INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18397">
        <property type="entry name" value="IKBKB_SDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="8"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="617"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RUS90815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="715" mass="82657" checksum="E2458D00410282A9" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BL64</accession>
    <name>A0A3S1BL64_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_022555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001606">
        <property type="protein sequence ID" value="RUS69682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BL64"/>
    <dbReference type="OrthoDB" id="10468858at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS69682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="263" mass="28462" checksum="A449B5572ABDDBA7" modified="2019-04-10" version="1">MLIISPPLTGELESTGSSFCVELPVVKLFQGQIIDPTPYTIGLMGLGEIKLGDRPSHTEIVPLSDPNNQGKTMLRLVLLCAFLATLLVAPTLAGLVRCQKLNEACVPVPLSCCRGMSCKRDNFGGGFRCEQGRGLLGRCYSRGQLCTPDLGNNPCCNGLVCKPRLLNPTIHESALCPHTMTSHTVLCLGLLVLLALCATGPVAGHKEWLCKDKFESCTPAAGDCCSGDAVTQWWNIGIRRKRYRVRILAFAFPTGWVGVRPQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BLL4</accession>
    <name>A0A3S1BLL4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SOCS box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_022279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001527">
        <property type="protein sequence ID" value="RUS69962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BLL4"/>
    <dbReference type="OrthoDB" id="9995210at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03587">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018539532" description="SOCS box domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="2">
        <location>
            <begin position="240"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS69962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="312" mass="34299" checksum="64FDB110221CE534" modified="2019-04-10" version="1">MQSALSILLMVGLVAFFRQGAAIMAGEWSARMYFAVVNNDAAGLAQMIADGGDVDQFYDDVTNVSSRSLLHVCCGRGHVQCLSSPRYLSLTPSIHPSPPHPPVYSGVTPALVCASTGDLETLRPLLQHNCCLTTKGSVYKRRRRLEYSLDPFELAYSEGFLHLCRLMVDAGYCVYGLRDSFLGDFHRQTSNPGEQTTHTNAHQDPIVIPIPAPASSGQNMANAEMPTLTFGHAQKLPDDWLDILLWLISKASNVRSLKEEAVFAVRAIIGHRLPDCIDSLPLPKLVKDYVMLKNLRLDDASAQHHGLFGKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BNV2</accession>
    <name>A0A3S1BNV2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S23</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_004254</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000095">
        <property type="protein sequence ID" value="RUS87976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BNV2"/>
    <dbReference type="STRING" id="188477.A0A3S1BNV2"/>
    <dbReference type="OrthoDB" id="1713912at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03367">
        <property type="entry name" value="Ribosomal_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000007">
        <property type="entry name" value="40S ribosomal protein S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005680">
        <property type="entry name" value="Ribosomal_uS12_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003254">
        <property type="entry name" value="PRK04211.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00982">
        <property type="entry name" value="uS12_E_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS87976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="174" mass="19913" checksum="E2DCE03D39BBEC71" modified="2019-04-10" version="1">MGKPMGLHTARKMKDHRREQRWHDKDYKKAHLGKPMGLHTARKMKDHRREQRWHDKDYKKAHLGTRWKANPFQGSSHAKGIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKITAFVPNDGCLNFIEENDEVLVAGFGRKGHAVGDIPGVRFKIVKVANVSLLALFKGRKERPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BS37</accession>
    <name>A0A3S1BS37_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_004817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000111">
        <property type="protein sequence ID" value="RUS87442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BS37"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS87442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="113" mass="12157" checksum="981A12A31D11AAC9" modified="2019-04-10" version="1" fragment="single">AIPPDEGNLPQGRVGPCGARRQTARLAVGGRVQGEWPNRKESEQKTLTFYGTSVRVPQCAVKQAPVVVDILDVNTVVEGQHDHLRDLVNVQTSGNIGPNAPTVRQFAPFSAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BU17</accession>
    <name>A0A3S1BU17_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_000578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000008">
        <property type="protein sequence ID" value="RUS91605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BU17"/>
    <dbReference type="STRING" id="188477.A0A3S1BU17"/>
    <dbReference type="OrthoDB" id="6117959at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018759490" evidence="1">
        <location>
            <begin position="21"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS91605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="436" mass="49396" checksum="1707B7BF931D27DD" modified="2019-04-10" version="1" fragment="single">MFSILARAALLPLVCQICFADDLTTLSDSVKGLQQVVADLSRHVMQLSFQDQERVRAEGSSGIVKVRGYTIGPNSYHFASHIGESFANMHDHSNYENLYGLGDFMAVMNGVNFRTRHNDFELRRASTTSKDWLATEPIESPPLPEGLDKLSVEDQIQEIREYIRAFKFQNSTIRPYQDFFKPVLCYLEGWWDSNITDIENGFTSSRHSFDAKSWRDLSDKAKADAFLGSDFNLKHEGASLPVTIMGIDETTKLPIYAQWNYRVLCHPLENDLPTAHIKPVEDLAYRQRMGIGALSLQMYRGSRYIVDANKEDVPQKKMTIDDLVSKIPGLDNIPGTLTEESYGRQGTGNLAFYNRAYPSDKDAMNSYDELRGFSDGNMYVAMTTQERVAPLVVQACSGSASNCEEHRIRCSWMFPLEIIYTSALQRWNPLNMPHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BUH3</accession>
    <name>A0A3S1BUH3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_017057</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000765">
        <property type="protein sequence ID" value="RUS75176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BUH3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS75176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="140" mass="15952" checksum="F53F5C82C1888C9D" modified="2019-04-10" version="1">MKKADIIHGDGHKVVKVKQAVGSLLHNVLDFSFLRGTFNSFHQSWSCNLFHQSWTCNSFIFVFSIRKQTAESNCRGKGILWYPLAVDGVDAICLEGLFDKLLCHHLLPNFFQEVQPTSPCLFSWTRFLPKTLLTVFGMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BUL3</accession>
    <name>A0A3S1BUL3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_000614</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000008">
        <property type="protein sequence ID" value="RUS91641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BUL3"/>
    <dbReference type="STRING" id="188477.A0A3S1BUL3"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052983">
        <property type="entry name" value="MFS_Riboflavin_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43385">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER RIBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43385:SF1">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER RIBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS91641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="409" mass="44434" checksum="2ED494EED8053BFF" modified="2019-04-10" version="1" fragment="single">YGNLSSYMDSYFQFACSPQCMDGDSQWILGLCVAMNCPGTLVTSYVANKVGLKMTGVMSAILVNVSLFAAAWSMKVSVFGTTILMGVMVGLVQGITSVVVYQYVYGWAADRSSLFIATSVGASTLLSLVQNQVITFIVNPYNLKPDAIRGSRAFFSQPELLERVPAAVFSYAAITAGLQLVGYLLLARRSSALLPPLSFSNEPQEKEGEPDEVKQISLTPSQALKTPTFYAAFLFGIVTQYSLLLKANFYKQFALLFIPDDRFLTLVGTFIPVVAASSRMSVGAALSARLITIKTACILSLSVNSVLCAFWYIVPQVDAVLYMFLVLSLALVQSMFFVIAPVVTLQNFGPEHFSTIYGLLMFSFAVVGLISPAVIPRLIHFLGWFGLFASASLMCLVTLLVVVCTDFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BV50</accession>
    <name>A0A3S1BV50_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Developmentally-regulated GTP-binding protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Translation factor GTPase DRG1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_016653</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000727">
        <property type="protein sequence ID" value="RUS75589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BV50"/>
    <dbReference type="STRING" id="188477.A0A3S1BV50"/>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008092">
        <property type="term" value="F:cytoskeletal protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031116">
        <property type="term" value="P:positive regulation of microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17230">
        <property type="entry name" value="TGS_DRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002634">
        <property type="entry name" value="Small GTP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="12">
        <location>
            <begin position="63"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="13">
        <location>
            <begin position="288"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00080795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS75589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="366" mass="40779" checksum="119FA7CA7CBB0AE3" modified="2019-04-10" version="1">MSILQKIADIESEMARTQKNKATSGHLGLLKAKLAKLRRELIEPKGGGGATGEGFDVAKTGDARIGFVGFPSVGKSTLLSNLAGVYSEVAAYEFTTLTTVPGVIRYKGAKIQLLDLPGIIEGAKDGKGRGKQVIAVARTCGLIFIVLDVLKPLQHKRLIEKELEGFGIRLNKEPPNIQFKKKEKGGLNLTSLVTQSELDHDLVKTILNEYKIHNADITLRVDATAEDLIDVIEGNRVYIPCIYLLNKIDQISIEELDIIYKVPHCVPISAHHKWNFDDLLEKMWDYLQLVRIYTKPKGQLPDYSSPVVLREGRSSVEDFCNKLHRSIIKEFKIALVWGSSVKHCPQRVGKEHVLADEDVVQIIKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C2Q8</accession>
    <name>A0A3S1C2Q8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GDP-L-fucose synthase</fullName>
            <ecNumber evidence="4">1.1.1.271</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_010951</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.271" evidence="4"/>
    <dbReference type="EMBL" id="RQTK01000346">
        <property type="protein sequence ID" value="RUS81277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C2Q8"/>
    <dbReference type="STRING" id="188477.A0A3S1C2Q8"/>
    <dbReference type="OrthoDB" id="202470at2759"/>
    <dbReference type="UniPathway" id="UPA00128">
        <property type="reaction ID" value="UER00191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050577">
        <property type="term" value="F:GDP-L-fucose synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042351">
        <property type="term" value="P:'de novo' GDP-L-fucose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05239">
        <property type="entry name" value="GDP_FS_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00956">
        <property type="entry name" value="GDP_fucose_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028614">
        <property type="entry name" value="GDP_fucose/colitose_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43238">
        <property type="entry name" value="GDP-L-FUCOSE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43238:SF1">
        <property type="entry name" value="GDP-L-FUCOSE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="9">
        <location>
            <begin position="7"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS81277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="318" mass="35790" checksum="0A4AC2F8D462915D" modified="2019-04-10" version="1">MADKKIILVTGGTGLVGNGIKAAMEKEGKREDEEWHFVSSKDADLQNLASTEAMFEKFKPTHVIHLAALVGGLYRNLKYNLDFFRINSQINDNVLSTAHKYKVKKVVSCLSTCIFPDKTTYPIDETMVHNGPPHDSNFGYSFSKRMIDVQNKGYHLQHGCNFTSVIPTNVFGPHDNFNLEDGHVLPGLIRKVFDAQASGNPFVIWGTGSPRRQFIYSLDLGRLFIWVMREYNEVTPIILSVGEEDEISIKEAADLVVEAVGFKGEVVQDTTKSDGQFKKTASNAKLRKYLPDFKFTPIKQAIKETCDWYAANTDKVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C7C7</accession>
    <name>A0A3S1C7C7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Arginase</fullName>
            <ecNumber evidence="2 12">3.5.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_007326</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>L-arginine + H2O = urea + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:20569"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="EC" id="3.5.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10 12">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the arginase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.1" evidence="2 12"/>
    <dbReference type="EMBL" id="RQTK01000189">
        <property type="protein sequence ID" value="RUS84916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C7C7"/>
    <dbReference type="STRING" id="188477.A0A3S1C7C7"/>
    <dbReference type="OrthoDB" id="9992747at2759"/>
    <dbReference type="UniPathway" id="UPA00158">
        <property type="reaction ID" value="UER00270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004053">
        <property type="term" value="F:arginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010121">
        <property type="term" value="P:L-arginine catabolic process to proline via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09989">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000005">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014033">
        <property type="entry name" value="Arginase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01229">
        <property type="entry name" value="rocF_arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782:SF3">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0056">Arginine metabolism</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10 12" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0835">Urea cycle</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR036979-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS84916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="320" mass="34229" checksum="080376CF16E8B169" modified="2019-04-10" version="1">MTGKTVGVLGFPFSKGQPKGGTELAPKELRAAGIVDRIQALGNNVIDHGDVDLSGLPADSKVGVAKNSLAVGEANKKLSEDVAKYLKKGEQVLLLGGDHSLGIGSLHGHTQVQPDTVVVWVDAHADLNTPFTSDSKNMHGMPLAYVVKEMAQFLPKTPGLEWCKPSLSTKDIVYIGLRDVDPGERKFIEQLGISCFSMHEVDKFAIKDVVEKALSQVDPSGNRPIHVSFDVDAMDPIHAASTGTKVPGGLTLREAFYIAEEIAATGRLSVLDMVEVNPKLGSPEEKEVTVANTVSVTAKFYGSKRQGDVPPNYVIPRPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1CBR4</accession>
    <name>A0A3S1CBR4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translocon-associated protein subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Signal sequence receptor subunit delta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EGW08_003863</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">EC2010</strain>
            <tissue evidence="16">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAP-delta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000085">
        <property type="protein sequence ID" value="RUS88351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1CBR4"/>
    <dbReference type="STRING" id="188477.A0A3S1CBR4"/>
    <dbReference type="OrthoDB" id="10055808at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008855">
        <property type="entry name" value="TRAP-delta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12731:SF1">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12731">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN, DELTA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05404">
        <property type="entry name" value="TRAP-delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018560149" description="Translocon-associated protein subunit delta" evidence="15">
        <location>
            <begin position="23"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RUS88351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="172" mass="18858" checksum="A750F26E06407739" modified="2019-04-10" version="1">MAALLKTLVAFTLVLLPVSISGDTCLAPKVTSQSYSTPEAVVSFDTVIIVEFSLTCKNNLKNINLYADVAGRTLPATKTSEPNKYQISLTDEPKKLPSGAYEIRFFDEEGFALLRKAQRSGESTGNLKPLFTINLNHPGIWSGPLIQSEFVAAMTAIIVWWMAYTQRGKLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H338</accession>
    <name>A0A3S1H338_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_020952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001239">
        <property type="protein sequence ID" value="RUS71285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H338"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS71285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="347" mass="36868" checksum="6BFD8AB55393A600" modified="2019-04-10" version="1">MPDQGRVSPDSSTQVKLSATMSSAGTSAGTRVCSPSPTPPSKSGPNHEESMKISSSSVKDGTTSVDASLELSSPCRTPENEKQLASDNGAPALSFPVSAMLNDLSKPQPSSRQPAEKRPALKMPPSPHGAFPLASPQQLHLGYAHAQLQQYFRSAAAAAAAAQLEEKNQTKTSHTSTKSAATSPGFENPLVSSHALLQAYGLIPASATAAQFNSGFITSPSYLTAQLSLLNSHLLHQNMLPFQANGLSSYPCYAQFLNKHRNDNSDDKWSAHSDRFQNGNFMEKEKEQIENHLVLSSASSSSSSSSSTLSPPASFPSPKEHEPRSRELPGNSDYDVPKNTVCADSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HAA7</accession>
    <name>A0A3S1HAA7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FERM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_016936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000753">
        <property type="protein sequence ID" value="RUS75315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HAA7"/>
    <dbReference type="STRING" id="188477.A0A3S1HAA7"/>
    <dbReference type="OrthoDB" id="10063592at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090162">
        <property type="term" value="P:establishment of epithelial cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047176">
        <property type="entry name" value="FRMD4A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46079:SF2">
        <property type="entry name" value="FERM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46079">
        <property type="entry name" value="FERM DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="1">
        <location>
            <begin position="107"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS75315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="239" mass="28059" checksum="859F003EA3D27B87" modified="2019-04-10" version="1">MLLQAVLTFIAILRRILSIWTLGIPRDFLVIEKPTYSYLLPVVGQFIVRVGLYCSSPVVSRISDTADRDRELLTKPSCGLANITFNMACTLAIYPELCMIHSMDNKICRRRSLLRPHRKYIFIQPKLYASDLLDLVASHFKLREKHYFGLGFYDETYHFNWLQGEKRVLDHEFPKKTGLLVLHFSIRYYVETIGLLRDTQTVELFYLNARQAIFRMIQWSRRSDKEDPCKKIGICIFPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HGK8</accession>
    <name>A0A3S1HGK8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_013295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000480">
        <property type="protein sequence ID" value="RUS78954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HGK8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS78954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="100" mass="10367" checksum="A635235DA6B2D5F2" modified="2019-04-10" version="1" fragment="single">MGSGASKKAESVPPTASSTQRSRPSNSRRADFQEVQVRPSGQDPAVANGNKAATLSTGDMSARQESSRESGSSHRNRYARHAADPSNGGSNSLQHGQSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HUL4</accession>
    <name>A0A3S1HUL4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_005800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000139">
        <property type="protein sequence ID" value="RUS86422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HUL4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS86422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="211" mass="23249" checksum="FF03D06C11AF4932" modified="2019-04-10" version="1">MTKFFHNTLRVPHIQNATERVRATQLWPVKQISVAKTQSRGFRTQSSSEEQPFQFHGGANRTDAQAKEEDSFKPATANPFESHGADIYSADISAAATAVVSSTASLAVFLFGFFLIHNLEGAVTVNDIYNASSVNERRGRGGDNSSTSNTSSPRGDHQLQVEHTIIVLNQIREAGRAASRHDMSHFQVSRTNTREPEVPVDSKDIHMSLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HXW9</accession>
    <name>A0A3S1HXW9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NudC domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_003899</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000086">
        <property type="protein sequence ID" value="RUS88328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HXW9"/>
    <dbReference type="STRING" id="188477.A0A3S1HXW9"/>
    <dbReference type="OrthoDB" id="428655at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06467">
        <property type="entry name" value="p23_NUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037895">
        <property type="entry name" value="NUDCD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21664">
        <property type="entry name" value="CHRONIC MYELOGENOUS LEUKEMIA TUMOR ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21664:SF1">
        <property type="entry name" value="NUDC DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="6">
        <location>
            <begin position="275"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS88328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="592" mass="66236" checksum="38834E87065AF92C" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HXY2</accession>
    <name>A0A3S1HXY2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SEA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_003917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000086">
        <property type="protein sequence ID" value="RUS88346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HXY2"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.960">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036364">
        <property type="entry name" value="SEA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01390">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82671">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEA" evidence="1">
        <location>
            <begin position="35"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS88346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="217" mass="25391" checksum="5B6C4A8947774E4E" modified="2019-04-10" version="1">MKNLARRKTNSIAQRQIEQFAELWNDGQRFGDAISYNYTFYMYRGNFTEQLRDKNSQRFKEQAYLFCKDVDDMFQKSGLRSVKKRYHGCVVDEFGPNLEVRIRVILRDIDIVRVSTMFSIFAYQSEQVLLEGISYLILGGIYVAFDADPVYRYLILETFTTHPYPYTTTTPSVEYSVITLTFSILSPDYSYDLSSVSSARYRLLAGSFCNDVSKRYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SI40</accession>
    <name>A0A433SI40_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Core Histone H2A/H2B/H3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_023785</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01002794">
        <property type="protein sequence ID" value="RUS68453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SI40"/>
    <dbReference type="STRING" id="188477.A0A433SI40"/>
    <dbReference type="OrthoDB" id="6114257at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000001">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="5">
        <location>
            <begin position="44"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="5">
        <location>
            <begin position="125"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS68453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="159" mass="18164" checksum="431814621AD17426" modified="2019-05-08" version="1" fragment="single">MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVGLFEDTNLCAIHAKRRNPSLPEETELLIRKLPFQRLVREIAQDFKINLRFQSSDVMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SIG7</accession>
    <name>A0A433SIG7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Temptin Cys/Cys disulfide domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_023789</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01002813">
        <property type="protein sequence ID" value="RUS68449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SIG7"/>
    <dbReference type="STRING" id="188477.A0A433SIG7"/>
    <dbReference type="OrthoDB" id="129121at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057626">
        <property type="entry name" value="S-S_Temptin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055313">
        <property type="entry name" value="Temptin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34737">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34737:SF2">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24784">
        <property type="entry name" value="Temptin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019090586" description="Temptin Cys/Cys disulfide domain-containing protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Temptin Cys/Cys disulfide" evidence="2">
        <location>
            <begin position="14"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS68449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="108" mass="11108" checksum="F0AF3CE9AE49E325" modified="2019-05-08" version="1" fragment="single">LPLLVSAALLGAVLALPNYVDLIPNGANVRLPCSESNCAVGHQNPAGDGALDAFGYDFAIAGRKWTQALCLQDSDGDGVSNGQELGDPECVWRVGESPARSSDISNPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SJK7</accession>
    <name>A0A433SJK7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_022992</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001760">
        <property type="protein sequence ID" value="RUS69246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SJK7"/>
    <dbReference type="OrthoDB" id="10252017at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043:SF8">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="6"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS69246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="212" mass="23420" checksum="52F35DD83A29AADA" modified="2019-05-08" version="1" fragment="single">MIKRGNKYQWLNEARKVDFIPWAPGQPNHGDPPVCISMNYFGNSKWTDDSCHSGEFFLCEKFPVDCSFEPDGFVCRKNCTSKCKERPNYVVCDDRTGNCWEGCADGYLGVKCDTPCNKTYYGFNCAFNCSTNCGGDEGLCDYESGNCTSGCNRGFMFEDTKCNSECPNGTYGLNCTKRCSPFCGGPGQYCKKDYGECLAGCVGGYTGDQCLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SK61</accession>
    <name>A0A433SK61_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isoamyl acetate-hydrolyzing esterase 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_022744</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable lipase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 'GDSL' lipolytic enzyme family. IAH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001664">
        <property type="protein sequence ID" value="RUS69497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SK61"/>
    <dbReference type="STRING" id="188477.A0A433SK61"/>
    <dbReference type="OrthoDB" id="671439at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01838">
        <property type="entry name" value="Isoamyl_acetate_hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045136">
        <property type="entry name" value="Iah1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209:SF19">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS69497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="241" mass="27266" checksum="DAC83BD3223A68A1" modified="2019-05-08" version="1">MENTVKMQKWPKVFLFGDSLTQLCFSPEGCWGAMLADQLTRRCDILARGFSGYNVRFCKELLPALLDKQTASETVAMTIFLGANDSNNKELNPQQHCPLEEYRQGLKDMVEFAMSQGVSREKIILITPPAVYEPDWRQYCKENGKTAALDNKVTETYAKACLEVADEMGTKKVDVYSRMVKEVDYQKYLSDGLHFSVKGSQLLFSLLWPIVQDLTSDLPELLFPRWDAINAADVKGSLLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SK70</accession>
    <name>A0A433SK70_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_022731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001660">
        <property type="protein sequence ID" value="RUS69507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SK70"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS69507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="215" mass="24295" checksum="17395E33A2025030" modified="2019-05-08" version="1">MRPYFVYYWSVLEYCHLLRHESWYRCLASVSTTKINKLVNIFNVFVPLLQFIGLFVVDSHGFSLPGVYLESSFPGFFCHTIELLLYVLLLLGEKADVVCKVKILQLLHEGPLDTFPSTCCILSHNRVNHHKEDRWGEQATLAHLMALVISALLGGLMLMSRSSVGDGISDTVLVCWSFCPVLGQVLQEPGGDLMMRPSRVSPKRHASFVSTFCRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SLX5</accession>
    <name>A0A433SLX5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_022084</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001479">
        <property type="protein sequence ID" value="RUS70152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SLX5"/>
    <dbReference type="STRING" id="188477.A0A433SLX5"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF36">
        <property type="entry name" value="D-BETA-HYDROXYBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS70152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="371" mass="41149" checksum="9E3A53E2DDB98E36" modified="2019-05-08" version="1" fragment="single">VAFAVAVLSKFLTNQFRFGFRSFLSLVILFLGEPLCQFLITGPSGLFIFSLGCLIIYSMLPANHLSAQDKAVLITGCDSGFGHALALKLDHLEMTVFAGCLDDQGKGAAELRDKCSDRLHVLKLDVTSREDIEAASKYIESHVREKGLWGLVNNAGVWWCAELDMMPEKILHRVMDVNLFGAIRLTSKLLPLVKKARGRVVNVSSLLGRMSMEGSGAYAMSKHAMVAYTNTLRLEMKKHGVGVSIVEPAGFLTGNLQEHTLSKRKEELWSSLDEEAKQHYGRDYLDALYSHVQSCFQKYPRDLSPVVRCIRSGLLSKRPREQYPCGPGAETMVTIYPLLPVWLADYISSSLSILPKNLFPGFVSSTKKGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SMD0</accession>
    <name>A0A433SMD0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tubulin polyglutamylase TTLL7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_021937</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tubulin--tyrosine ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001444">
        <property type="protein sequence ID" value="RUS70298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SMD0"/>
    <dbReference type="STRING" id="188477.A0A433SMD0"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070740">
        <property type="term" value="F:tubulin-glutamic acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000009">
        <property type="entry name" value="tubulin polyglutamylase TTLL5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241:SF147">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE TTLL7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="29"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="560"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="877"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="459"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="593"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="613"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="644"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="877"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS70298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="949" mass="108939" checksum="44337E024BE783BA" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SQ46</accession>
    <name>A0A433SQ46_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein N-terminal asparagine amidohydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_020873</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001226">
        <property type="protein sequence ID" value="RUS71364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SQ46"/>
    <dbReference type="STRING" id="188477.A0A433SQ46"/>
    <dbReference type="OrthoDB" id="539995at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008418">
        <property type="term" value="F:protein-N-terminal asparagine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026750">
        <property type="entry name" value="NTAN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12498">
        <property type="entry name" value="N-TERMINAL ASPARAGINE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12498:SF0">
        <property type="entry name" value="PROTEIN N-TERMINAL ASPARAGINE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14736">
        <property type="entry name" value="N_Asn_amidohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS71364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="34609" checksum="6B5DB953BB1F9D67" modified="2019-05-08" version="1">MPLIVDDKEIKKASKVDEFVTLFPHFKKSSDELIKQSVEVVGPEQLLYIGQRELAGTSPDDDVISILGSEDATTCHIMVLRHTGSGAAAMVHYDGSSVAEGLQNMISIVEDLTEDMQAGRLEVHLVGGFVDERKNSHEVSDKVIEALCESSYRLHLVTACITHFNTEYRNSVPFPIIYGVAFDVKAGRLFRAKFPDKGPDMALRGARHCTGSKENLNIYNPQTHRLEIGPFHYDRLPNVDLFLSLPESHIRKYLSTSPEQEPDTFCESVRAGLIQLRDFPNPLQTVFNGGKPKVYAKDKRSGLWQLQPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SRK7</accession>
    <name>A0A433SRK7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_020343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001144">
        <property type="protein sequence ID" value="RUS71890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SRK7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019251412" description="EGF-like domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS71890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="108" mass="11838" checksum="4C4DA00554308DA3" modified="2019-05-08" version="1">MHMYEMRLTIWSLLVMTFFLGACLAGHRCESECLNGGSYYTWGELAKGKRICMCSKNFTGPCCELSTFNDPHILLTNAGASGLNPPAAISCLLLAGFLCRLPGLLWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SS23</accession>
    <name>A0A433SS23_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_020181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001121">
        <property type="protein sequence ID" value="RUS72052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SS23"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="723"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="771"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="425"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="723"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS72052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="896" mass="99193" checksum="38F9D6D744363A7A" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433STA6</accession>
    <name>A0A433STA6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">VWFC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_019777</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001064">
        <property type="protein sequence ID" value="RUS72460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433STA6"/>
    <dbReference type="STRING" id="188477.A0A433STA6"/>
    <dbReference type="OrthoDB" id="6158741at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030020">
        <property type="term" value="F:extracellular matrix structural constituent conferring tensile strength"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1082">
        <property type="entry name" value="COLLAGEN TRIPLE HELIX REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019314139" description="VWFC domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="519"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="569"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="645"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="729"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="780"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS72460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="793" mass="76023" checksum="C6292B323281E8DD" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SUF6</accession>
    <name>A0A433SUF6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Microsomal signal peptidase 12 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_019330</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Dispensable for SPC enzymatic activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001001">
        <property type="protein sequence ID" value="RUS72910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SUF6"/>
    <dbReference type="STRING" id="188477.A0A433SUF6"/>
    <dbReference type="OrthoDB" id="263893at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009542">
        <property type="entry name" value="Spc1/SPCS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 12 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06645">
        <property type="entry name" value="SPC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS72910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="114" mass="12721" checksum="9912EE9A908EA931" modified="2019-05-08" version="1">MDYILPYVPESIKSIPTHMDFDGQKRAERYFQIIILAFAAVGFACGYITQFFSHTVYILFAGVIISSLLTLFPWSTYRKQPLAWQPARSADGKSPAPAVTGGSQSKGKKKKLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SUN2</accession>
    <name>A0A433SUN2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EGW08_019243</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">EC2010</strain>
            <tissue evidence="17">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="RQTK01000988">
        <property type="protein sequence ID" value="RUS72995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SUN2"/>
    <dbReference type="STRING" id="188477.A0A433SUN2"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046972">
        <property type="term" value="F:histone H4K16 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000013">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000002">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF219">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="16">
        <location>
            <begin position="165"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RUS72995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="461" mass="53365" checksum="E44A65BBBD58838B" modified="2019-05-08" version="1">MAEVKNEIVEGCHVPVLLPNGDGWHASEVLSIKEINGKSLFYIHYEDYNKRLDEWVPIERMDLSKLEQPKKDIKTPIKKEGGVGASRVSNGGTESRPCSPEREIYENGTMQSLGLSNSGAMKVHTGCDGFGNRKRKLDEDTDSQDAPLAPRQTGSMVAHHDDIITRMKNVNLIEFGKWRIKPWYFSPYPQELTNLPILYICEYCLKYLKSAKCLERHLAKCLYKHPPGNEIYRKDKISVFEIDGRKNKQYAQHLCLLAKLFLDHKTLYFDTDPFLFYCLCEQDAQGYHLVGFFSKEKESAEDFNVACILTMPPYQRMGYGKVLIEFRFTLQKRALLNCNSDEKYSNPPFLPFYIYQFMLLFALLIVSKLNSLSQAVISIACYLRDSTFVIEISELTSIKKDDVISTLQHLNLINYYKGQYIITLSDEQIQTQERGMAKRPIRIDPKCLHWQPKDWSKRGKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SUW9</accession>
    <name>A0A433SUW9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transformation/transcription domain-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_019155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000978">
        <property type="protein sequence ID" value="RUS73094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A433SUW9"/>
    <dbReference type="OrthoDB" id="5570127at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046807">
        <property type="entry name" value="Tra1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046805">
        <property type="entry name" value="Tra1_ring"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF1">
        <property type="entry name" value="TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20175">
        <property type="entry name" value="Tra1_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20206">
        <property type="entry name" value="Tra1_ring"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1919"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS73094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1919" mass="217953" checksum="0E49A7468C0EFB97" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SW75</accession>
    <name>A0A433SW75_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_018700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000926">
        <property type="protein sequence ID" value="RUS73542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SW75"/>
    <dbReference type="OrthoDB" id="6134903at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS73542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="272" mass="30626" checksum="F85ED89E4D49058C" modified="2019-05-08" version="1">MGLDLTYATGSPEEHRAKATPLHLTRFWASLFSSVHVLPALLISASILLRHVCLGRPTFRLPCRYLAISREMSNSYLTFLTIVALKEVTVAHGQGFAFSTELSYWQLSSGMRGLFRSEMELLKNTVLLSGGPSQPRIHTIWINSQSFLVNHQDVEKTISEFMLDNQIRGVGSVEFNSGRYVQGCCPQLTFYSAIDSLPNINGVRKYLVHFEKEGKYQYVPFSLCAGQDKYGDHGHCFQGTTVLNLLAYETERSPPVSFDQFEIPTYCGCVQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SXA5</accession>
    <name>A0A433SXA5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_018359</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000890">
        <property type="protein sequence ID" value="RUS73889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SXA5"/>
    <dbReference type="OrthoDB" id="6341251at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS73889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="165" mass="19342" checksum="8E8DC8199581FC5B" modified="2019-05-08" version="1" fragment="single">KDCAVSLYHHIKPGANELFTFDNFIQGYIRDDYTVRSHQFNYLRQMSQFEQANPNHPIIHIHFEDLKRDPLPVLLKLADFVNVRTTDEFCQEVISACGLDKMRKADVARPLPVNLTQVYSKGYNIYRKGMVGDWKNTFTVAQNELFDRFLAAQQEKGNAYDLRWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SXL0</accession>
    <name>A0A433SXL0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_018193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000872">
        <property type="protein sequence ID" value="RUS74044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SXL0"/>
    <dbReference type="OrthoDB" id="10683105at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS74044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="436" mass="47474" checksum="C32E745BE0B213B2" modified="2019-05-08" version="1">MEQVARFEPKPSLLMCLPPRYQLGHPPHPVRMSPTHLDLLGGDGGIHGNGGLPRNHVTQTSLDTSDQSERPIRGGSGHNMSSLAASKPWGPDSDRGDEVSSLDMKNNVNSMKDGALTSSLDLAVSKQLTSRSRGSPSPVKDRVLGLGPHRHPLSLLAGGPERVLYHPYSNYSTPTSGHHHQHHHYRQLLHQHQHKHHLQQQGSGHDTRLGEEEISEKPNKMEPRNDLDFRPSHVIVSSSGSPEHHQHQHNHRYNTSNTSNKNKNNSNTTTTTTNPDQCRVDPHNHSSDSGLNDSNTSAVSLDIDTSDSGVVSGISAHTISSDDDVTGVSCSGTQYDDEQLPITSGVDRPDNTRRKLNDNVNDADENEDDDEDIRVSSNDDDDDEDGLRGFDRGLHAGQRTPTGLSAGGTGRVKQSSDDKIGAHHGDGKGKRALRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SYZ4</accession>
    <name>A0A433SYZ4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_017861</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000836">
        <property type="protein sequence ID" value="RUS74380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SYZ4"/>
    <dbReference type="STRING" id="188477.A0A433SYZ4"/>
    <dbReference type="OrthoDB" id="9451254at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000958">
        <property type="entry name" value="Odd skipped"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000311">
        <property type="entry name" value="protein odd-skipped-related 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002190">
        <property type="entry name" value="Zinc finger protein 658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050717">
        <property type="entry name" value="C2H2-ZF_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196">
        <property type="entry name" value="ODD-SKIPPED - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196:SF0">
        <property type="entry name" value="PROTEIN BOWEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS74380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="285" mass="32427" checksum="0D8AFEF9655025AA" modified="2019-05-08" version="1">MVSPPLNIKLSDVSLGTHRRAGPSGRTKETLNPIIRTMVDAFDIKRGPMPATIFSPLSSHLVPPGICPVPALTHGVCANIWTQQTVLCSPQYHKHQNLISEDYHHQIKLGSVEVESETSGKCDKAMEAVSVARKPRFDFANLPRSVSRENEADERPGQNKKRRVKVISHVTSVTYAYRPKKRFICKFCSREFTKSYNLLIHERTHTDERPFSCEACGKAFRRQDHLRDHRYIHSKEKPYRCLECGKGFCQARTLTVHKAMHAQAANGKLNQRRQKTKQKTINSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SZX7</accession>
    <name>A0A433SZX7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_017399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000794">
        <property type="protein sequence ID" value="RUS74842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SZX7"/>
    <dbReference type="OrthoDB" id="6217368at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS74842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="301" mass="32536" checksum="6E68BA83CE741FEF" modified="2019-05-08" version="1">MAARMNPRILAAKEKMLDDLVGEFKDRLDIFSTEVKTKMRSSSNEMATHMFEVVLLFLTQVFPDLSTLDSGSESTLSGFEKDLAETKQSLAETKQSLSETKQSLSETKQSLSETKQSLLETKQSLSETKQSLSETKKSLSETKQSHRFLSTKILKNEEKAILFKRQIKKLNKVSETNTHQIWGLRKLQKLLSNMTMTIQTAAAAAVAAAVPSAQATAATPQSAQATAATPQSAQATAATPSAQATAATPQSAQATAATPRGPPKSLRHESTFSAKTAGDSETPCIEDMKLLPGGLVLLSDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T1E0</accession>
    <name>A0A433T1E0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VWFD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_016884</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000748">
        <property type="protein sequence ID" value="RUS75362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T1E0"/>
    <dbReference type="STRING" id="188477.A0A433T1E0"/>
    <dbReference type="OrthoDB" id="6139853at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050780">
        <property type="entry name" value="Mucin_vWF_Thrombospondin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339">
        <property type="entry name" value="EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339:SF373">
        <property type="entry name" value="VWFD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFD" evidence="3">
        <location>
            <begin position="201"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS75362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="897" mass="100067" checksum="D67AEF25AE4CFC83" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T301</accession>
    <name>A0A433T301_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_016369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000704">
        <property type="protein sequence ID" value="RUS75880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T301"/>
    <dbReference type="STRING" id="188477.A0A433T301"/>
    <dbReference type="OrthoDB" id="8916892at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS75880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="251" mass="26179" checksum="D4457FADFEB739B2" modified="2019-05-08" version="1" fragment="single">MLFGGPNKESAPSSGTASPASVPPGVQHKMKTLAELEADLHQSSPHKPASPASTTGPATTQEGGSGDMTAFNKLLFMMNAGPEANQNNTSSEAQNSRPGFPMIPSYSQFSKAVLRNKEEQKLLQQTAQHQLMAGLVPSVSQHQPHLGQPPAPGQAISAAALQQMQLQQAGLAHRTAGKMPFSLTPQAMSTPHSSAVTNQARPHSSSSVGPILSLIQQNPSIVMKPASPGMSAPQQQSQTGMPKTARVASPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T6B9</accession>
    <name>A0A433T6B9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 6</fullName>
            <shortName evidence="6">eIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">EIF6</name>
        <name evidence="7" type="ORF">EGW08_015178</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 60S ribosomal subunit. Interacts with RACK1. Interacts with DICER1, AGO2, TARBP2, MOV10 and RPL7A; they form a large RNA-induced silencing complex (RISC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <text evidence="6">Shuttles between cytoplasm and nucleus/nucleolus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eIF-6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000613">
        <property type="protein sequence ID" value="RUS77066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T6B9"/>
    <dbReference type="STRING" id="188477.A0A433T6B9"/>
    <dbReference type="OrthoDB" id="4155914at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00527">
        <property type="entry name" value="IF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.75.10.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006413">
        <property type="entry name" value="IF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00062592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS77066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="245" mass="26468" checksum="B7657E28C10CF260" modified="2019-05-08" version="1">MAVRAQFEGNNEIGVFSKLTNNYCLVGIGGSENFYSVFEGELGDSIPVVHASIAGCRVIGRMCVGNRNGLLVPNTTTDQELQHIRNALPDTVKIYRAEEKLSALGNVIACNDYVALVHPDLDRETEDLLVDTLNVEVFRHTVANNVLVGSYAVFSNQGGMVPPKTSVEDLDELSSLLQVPLVAGTVNRGSDVLAAGMVVNDWMAVCGHDTTSTEVSVLESVFKLSDHEPSQIQTQMRDSLVDTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T6R4</accession>
    <name>A0A433T6R4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_015022</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000599">
        <property type="protein sequence ID" value="RUS77218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T6R4"/>
    <dbReference type="STRING" id="188477.A0A433T6R4"/>
    <dbReference type="OrthoDB" id="7832001at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05676">
        <property type="entry name" value="M20_dipept_like_CNDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF4">
        <property type="entry name" value="CARNOSINE DIPEPTIDASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="4">
        <location>
            <begin position="196"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS77218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="459" mass="51045" checksum="20F5B7BB5494C593" modified="2019-05-08" version="1">MDKLFEQIDKNEARYVQRLSEAVAIQSVSAWPEKRSEIKRMIEWAGQMVTNLGGTVEYADIGEQTLPDKSKIRLPPVLLGTLGSDPKKKTLLVYGHLDVQPAEKSDGWDTEPFVMTEVDGKFYGRGSTDDKGPVIGWINCLEAMQELQMDLPINFKFVFEGMEESGSLGLDELIEKRKGDFLKVCKTISVYLPCTLRGICYFELKVTCAKQDLHSGLFGGTVHEAMNDLIALMSQLTDVNHKILVPGLYDSVQELTAEEKATYDPIDFDPEDYRKDIGAKKLIHAEKPDLLMARWRYPSLSLHGIEGAFSAPGAKTVIPREVIGKFSIRLVPHMSPPEVEKLVVDYLTKLHKERGSPNNMEVSMGHGGRPWVSDVNDPNYVAARNAIKTVHGVEPDLTREGGSIPVTLTFQEATGKNVILLPMGSSDDGAHSQNEKLNKSNYMLGMKVFAAYIDELGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-05-03" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T9C7</accession>
    <name>A0A433T9C7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_014094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000530">
        <property type="protein sequence ID" value="RUS78146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T9C7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS78146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="139" mass="15693" checksum="B85F8529AAAB2593" modified="2019-05-08" version="1">MGNMGATVSRTKEALYRGRERIISLSLGLTSPRFPWGSYTTIEQRRETYNNYTRRSRCNSDIMIQRKDVNHVGRCNGLKGIVCIEQVNGGGNKGGRQIHVSYNTQSIIIIILSSVRDDNTGFRSCSIFMHLELKTESTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TA46</accession>
    <name>A0A433TA46_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_013928</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000518">
        <property type="protein sequence ID" value="RUS78324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TA46"/>
    <dbReference type="STRING" id="188477.A0A433TA46"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF1">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS78324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="254" mass="28602" checksum="0E706417291EACF4" modified="2019-05-08" version="1">MHPRLVTSDDAPQKTLAVMSESFQQLCTDRFPLCLHFHSELSRRIRQDKVKDVVIQHDNARPHTSRQTQCALQQLELPTIPHPTYSPDLAPSDFFLFPLLKKHLKGNHYETDAEVEADVRSWCRSQTPEFFADGMRKLVQRWRLCIERDASDSKSEMRAAVWQLPNSDMEPSSPGGDDSSSAHPHLNLMCYLEALPEDSGGKADVRSVLWHPAGDSQALIGICEDRLICWDLNTASSSAKVGCRIAIRLVTRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TIR4</accession>
    <name>A0A433TIR4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_010762</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000336">
        <property type="protein sequence ID" value="RUS81464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TIR4"/>
    <dbReference type="OrthoDB" id="10465165at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019531528" evidence="2">
        <location>
            <begin position="24"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS81464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="234" mass="23510" checksum="AF9FEDB6A9A61486" modified="2019-05-08" version="1">MAAGRFSVVNCLLVLLVVYPAHSQVQQCADQIGSCSGPFILAKEAGMGDICSAFNTFTSCVNSISDCNLGEQEKQLIIQEFSSGINCDGSGSGTSTGTGTGTGTGTGTGTGTGTGTGTGTGGIDPLFASVVLLFSGYGCIQVPSQCSANIGPSSDCSAVKASGQCMFNDCPKIRGTGDDTKAASLLVQSAQNSFSCSFTSSELTGSGALGVLQRPVWESLGLVLVAALVTSFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TJS6</accession>
    <name>A0A433TJS6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_010370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000317">
        <property type="protein sequence ID" value="RUS81847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TJS6"/>
    <dbReference type="OrthoDB" id="10484445at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS81847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="208" mass="22604" checksum="88B24EF6A75D95DE" modified="2019-05-08" version="1">MSSPGIEIPTVEVQEVDDALEEEPVVLVKQSPRQESPDARPVESDILANTAEKDRFEDDKPPSPPAREPLPSTPLYEREDRGASSSHSKQTSYSAKQYKSPAQPHSSSRSGSRLLGPSYAAHRPPREYASTLDIGAALSREFRGTSPSVLEKIASHPLLQSGGFEPLRHPSLSARSRKVLRQAGDLVYTAPGLKNLLEVCASGMVGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TQ40</accession>
    <name>A0A433TQ40_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC-type glutathione-S-conjugate transporter</fullName>
            <ecNumber evidence="10">7.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EGW08_008573</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">EC2010</strain>
            <tissue evidence="16">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>leukotriene C4(in) + ATP + H2O = leukotriene C4(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38963"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57973"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:38964"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.3" evidence="10"/>
    <dbReference type="EMBL" id="RQTK01000235">
        <property type="protein sequence ID" value="RUS83667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A433TQ40"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015431">
        <property type="term" value="F:ABC-type glutathione S-conjugate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000006">
        <property type="entry name" value="ATP-binding cassette, sub-family C (CFTR/MRP), member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000074">
        <property type="entry name" value="Multidrug resistance-associated protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="273"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="495"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="540"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="896"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="948"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1018"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1046"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1133"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="289"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="577"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="948"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="1364"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1204"/>
            <end position="1241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RUS83667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1625" mass="180713" checksum="B54A433A9EC558AA" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TU90</accession>
    <name>A0A433TU90_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_007114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000181">
        <property type="protein sequence ID" value="RUS85109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TU90"/>
    <dbReference type="OrthoDB" id="10054965at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39297">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39297:SF1">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019050394" description="CUB domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS85109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="24752" checksum="172FDC85BC881EF1" modified="2019-05-08" version="1">MYKSFLALLLNCAPLYFTLVCGKCPPDDPSQVIEYVAIPEDQYDRNFSSISDIGKRPLGFDRAVWYYNNPDENPCVKITGASQRRIEIMFETHPSSRLCVKDQDSQTQCSDAGTGSFYDCRKSTQDTLYFEFFCNQGEEYDVRFWYRLVLGDLPADDPEDMWCEDRDQESPANLLRLEPDFPIQDATTPSPDTALTLCPTSLLVFALSGLACLALVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TWL8</accession>
    <name>A0A433TWL8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_006246</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000154">
        <property type="protein sequence ID" value="RUS85976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TWL8"/>
    <dbReference type="STRING" id="188477.A0A433TWL8"/>
    <dbReference type="OrthoDB" id="6101607at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF18">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="73"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS85976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="400" mass="44272" checksum="EC11CD27B5C337C0" modified="2019-05-08" version="1">MNSTPSDWLAGLANEWTSPGLANLAGEALEEKKSYGDVFIASEAIISNHALEIIENLIDVFVISLLALLGIVTNILDLAVFYRQGFKDSVNISLAAIAVWDLIKCVCGIAIRVYGPLGWHSRAYRYTWKSLTTPTLVYLQVFANYVSYVLAAYVSFERCLCVTIPFKVKSIVTPKLTFIMMILISVLVIASFGVIFFIYDISWVYSSHFNATVAVFEFNSFHRNHGPVVIAYFNLIGIINPIFCFIVIVTCTAIIVYQLNKMSKFRAAATAASTKTDSSSAVATSTSAAAAKAASNAAAGNSLSSRDRQVVKMLVVVIIVYIVALLPRFAHYAGKFTEPDFAYLRRYHNMFTLSSYIVLTFDYINASVNLFIYLTMSTNFRATFYQMFPACGKQKLSNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TY08</accession>
    <name>A0A433TY08_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_005786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000138">
        <property type="protein sequence ID" value="RUS86471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TY08"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS86471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="128" mass="14598" checksum="1019C594377BD1B5" modified="2019-05-08" version="1" fragment="single">VDRFNVHQAHAQNARHEAAEASDAARRSPHAGASVVAVQDKHRHGHGQRRHGHDHAQPTYERDVLRGGRHVLRHEQHEDGEGEQHREAQGDLLARLGRQQEACQRQTRQHHARDDHVQEVVEHSTPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U0T3</accession>
    <name>A0A433U0T3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lipocalin/cytosolic fatty-acid binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_004900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000113">
        <property type="protein sequence ID" value="RUS87358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U0T3"/>
    <dbReference type="OrthoDB" id="6095636at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS87358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="15225" checksum="6056C5016E209EEC" modified="2019-05-08" version="1">MTTGVETFKFDMDKSPEVTDFAFATGTPKEFCTKDVMSKVRFHHSVDGEQFTSKVDIPGMAPRVFHYKLGVPYDFTAQDGRKFKITTTCEAEKFIEKMVADNGDEIITVREDTGNGFKSTTTTKGKTITHYMVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U1A7</accession>
    <name>A0A433U1A7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_004632</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000106">
        <property type="protein sequence ID" value="RUS87587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U1A7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS87587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="127" mass="14600" checksum="6D88AADCAF8AFBE0" modified="2019-05-08" version="1" fragment="single">KLKYTSAVTNTSFFVPRTELASRRFKVTGRDPNFFFETHFFFPKRHGVFETFEFRTRVAPPTKFRNLIPVVGLFRMVDVDIDKRLEVCSFTHSYKRLAIRVTADSPVPYIGVLNSGGDTTINAYALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U1Z2</accession>
    <name>A0A433U1Z2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_004514</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000102">
        <property type="protein sequence ID" value="RUS87768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A433U1Z2"/>
    <dbReference type="OrthoDB" id="18853at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000023">
        <property type="entry name" value="EH domain-binding protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022735">
        <property type="entry name" value="bMERB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050540">
        <property type="entry name" value="F-actin_Monoox_Mical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167">
        <property type="entry name" value="CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167:SF46">
        <property type="entry name" value="EPS15 HOMOLOGY DOMAIN CONTAINING PROTEIN-BINDING PROTEIN 1, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12130">
        <property type="entry name" value="bMERB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01203">
        <property type="entry name" value="DUF3585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51848">
        <property type="entry name" value="BMERB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="3"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="BMERB" evidence="7">
        <location>
            <begin position="1513"/>
            <end position="1661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="125"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="209"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="546"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="772"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1004"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1088"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1480"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="285"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="341"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="421"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="439"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="514"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="571"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="613"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="646"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="685"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="717"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="788"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="869"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="908"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="958"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1004"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1034"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1097"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1108"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1127"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1178"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1228"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1302"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1334"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1395"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1415"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1436"/>
            <end position="1451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS87768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1691" mass="184722" checksum="F90A6BF8FEE13939" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U3X6</accession>
    <name>A0A433U3X6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">[heparan sulfate]-glucosamine N-sulfotransferase</fullName>
            <ecNumber evidence="5">2.8.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">EGW08_003708</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">EC2010</strain>
            <tissue evidence="23">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; heparan sulfate biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; heparin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sulfotransferase 1 family. NDST subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.8" evidence="5"/>
    <dbReference type="EMBL" id="RQTK01000080">
        <property type="protein sequence ID" value="RUS88532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U3X6"/>
    <dbReference type="STRING" id="188477.A0A433U3X6"/>
    <dbReference type="OrthoDB" id="8958249at2759"/>
    <dbReference type="UniPathway" id="UPA00756"/>
    <dbReference type="UniPathway" id="UPA00862"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019213">
        <property type="term" value="F:deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015016">
        <property type="term" value="F:heparan sulfate N-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015012">
        <property type="term" value="P:heparan sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030210">
        <property type="term" value="P:heparin proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021930">
        <property type="entry name" value="Heparan_SO4_deacetylase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056793">
        <property type="entry name" value="HSNSD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037359">
        <property type="entry name" value="NST/OST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605:SF56">
        <property type="entry name" value="BIFUNCTIONAL HEPARAN SULFATE N-DEACETYLASE_N-SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605">
        <property type="entry name" value="HEPARAN SULFATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12062">
        <property type="entry name" value="HSNSD-CE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25119">
        <property type="entry name" value="HSNSD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Heparan sulfate-N-deacetylase N-terminal" evidence="22">
        <location>
            <begin position="93"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Heparan sulphate-N-deacetylase deacetylase" evidence="21">
        <location>
            <begin position="318"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="20">
        <location>
            <begin position="611"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="active site" description="For sulfotransferase activity" evidence="16">
        <location>
            <position position="620"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="718"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="823"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="839"/>
            <end position="843"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="824"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF12062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF25119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="RUS88532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="892" mass="104235" checksum="B025EEAC84717633" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U599</accession>
    <name>A0A433U599_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_003300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000070">
        <property type="protein sequence ID" value="RUS88964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U599"/>
    <dbReference type="OrthoDB" id="6073134at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS88964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="42383" checksum="414057397296E82B" modified="2019-05-08" version="1" fragment="single">TTCTYRLISCQSREQDSLFLAHWIFAGADILLGFPVTMENASNITNTSRRYDSFMDEYRLVMSWTLGMETVFMLVGTALNLWLMLSILTSRDLRVRMRNQLVVNMNAVHLVHTMFTSPVIILQCIAVLKRVFWSYEFFCHTYSIIIIIEFIQSFIADWLMVFIMCIFISNITDIDLASKVTPLVSRLIKATMHLLPWLVAIIVTPISISQVTRWYPCLLVPYKQLYIFETVYTVIPTCLTVLLMVAAVVLRFRRFSTGSSTASGNMGVQLLGKGPEIDNTFAYLLAAAVCVACEICHLVFVFEIMDWKYRGLRFEMVGYILSDSRVILMVFPWLLLPDIRQRIRNWRPWRREITGIDLTMAYGKETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U608</accession>
    <name>A0A433U608_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spaetzle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_002953</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000060">
        <property type="protein sequence ID" value="RUS89279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U608"/>
    <dbReference type="STRING" id="188477.A0A433U608"/>
    <dbReference type="OrthoDB" id="10509064at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019565400" description="Spaetzle domain-containing protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS89279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="417" mass="46004" checksum="0794F32FD91D7F89" modified="2019-05-08" version="1" fragment="single">KMLVMSRCWRFLLLLACTLTPAPVLVMGQLSIPRLREMSQEGNTSLEYIMGVVMMNLPQELVSRIQAKLTLSSAANRGFGVSKTWIYRSSSGTTNINIDSTGDNSGTGIINNVDNSEPIRLNLRRKKRSFGLFDSDLFGSSGYGSFHHPGASSGGFGFGYGYGYPKGYDGTSHTHPESPGHAHPGDQNGNLFGGAATSYVTYPGERENLQGQSTHGHKSYNSFHGSRFGQGGFNKENCPRQADQGFVYQYDGDALTYPAIEIGNELFTRSLPGSDLLFQALNRQIVFPTDPPKIFIDEFLLSSNVTCPFKEDQVWSYRSQTLCPATKGDQLKVLVPFFKKCLNRFCKNCGGVKSDFFWGSSASNSANVCVTEYQTVTLWSYCEELTPNRRIVSDRILVPNACTCTTVPCPSHHGYHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U660</accession>
    <name>A0A433U660_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">28S ribosomal protein S27, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_002933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000059">
        <property type="protein sequence ID" value="RUS89326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U660"/>
    <dbReference type="STRING" id="188477.A0A433U660"/>
    <dbReference type="OrthoDB" id="19830at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034913">
        <property type="entry name" value="mS27/PTCD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019266">
        <property type="entry name" value="Ribosomal_mS27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21393">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21393:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10037">
        <property type="entry name" value="MRP-S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS89326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="473" mass="54357" checksum="93BC64EF8ED6911B" modified="2019-05-08" version="1">MATSLRQIALLGRQTWRQLKVISLGRKFSTTSKRMLLSETYYCNDAWRKHLQDPNLNQVNVAEFGYQIRDQLEMSGTVSAIDMNVLVHQLRNMDDDEADFIEDLLARFNMCQSSIPPSDSTAHAIIRSFLTKSYDGSARLVRLLSQPLQYGLFPDHYSLNLLLDKLIDSGDPAGASRVAYHTMLQEDLSSNPVHTLLCLQAAVARVLQGPISDLALPEPEKVEDEEEDWIKVKYIKFPVYDDHFDIKDERFLLGKTLHMLAQVQTPKCPELIVTSLGLIGSGIHHKFSQGLAVLEKVVDSSSGSVPLQALELFSESLESVQARDPEEPEVEIALRTVDDVIHRLLPTTEEKDEFQRRFGQLKEKLVSQEKIQEDFDLGPAVKDFVRSELPNYEKSDIEEQINKFSQWQRERESELTHQVEELMKNQRMEEIKKQVKELQEQEELLSYFDFEEKIRLTMMDEDLAKDENLTIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U6E6</accession>
    <name>A0A433U6E6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein zer-1 homolog-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_002839</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000057">
        <property type="protein sequence ID" value="RUS89402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U6E6"/>
    <dbReference type="OrthoDB" id="7537227at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055142">
        <property type="entry name" value="ZER1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22964">
        <property type="entry name" value="ZER1-like_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Protein zer-1 homolog-like C-terminal" evidence="3">
        <location>
            <begin position="4"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="108"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="152"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS89402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="375" mass="41089" checksum="B24CA543D51A889F" modified="2019-05-08" version="1" fragment="single">MRALYNLSSNELTAGAVSVLPIPRLVQQVLANFPDSVELLEITMVTLSQVMLGDDELYQALARSHCVVDIVSTMFNFPENTLIQESGCKVLGNLAVRDDLRKLVEADGASKAVISALLTLDTCADIQEVGCIALMNLTADNEDNKIRIKNAGVVPALVNTLKEFRYSSDIVLCALKALGNIVSLEEVCHQFVDENGLNLLNSLIDTHETNKEVLTFVSLVLCSITDLPDLQADQVTVIDSRLMSILSLVPRNPDITLYVCQAFENLIKTDEGRETFTRCGRMRVILNAMSTFRDNSQIHRCCCKVIAVVSLSVDIRKNLISVSSLESVLGSMQLFPSDLELQIIGCGTLACLLEKTDLLREKLIEQGGITLIGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U6I3</accession>
    <name>A0A433U6I3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_002841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000057">
        <property type="protein sequence ID" value="RUS89404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U6I3"/>
    <dbReference type="STRING" id="188477.A0A433U6I3"/>
    <dbReference type="OrthoDB" id="10264505at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="90"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS89404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="153" mass="17358" checksum="1B3D33DF53E8AFB3" modified="2019-05-08" version="1" fragment="single">ILFATLDVSKYQALRDERFKSRETPIIIWLPVADKTKPKRFGGVHSVELLTTFINERTGLHRNSDGALQPQAGLIPKAESVLQHHMEQILAADTKTLKEVKEALLELKETEAEHHQEMLKYYMYLVDKMAATGGTHVVDEMVSALDRTLFGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UAB7</accession>
    <name>A0A433UAB7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase 9-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_001536</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family. GNAT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000026">
        <property type="protein sequence ID" value="RUS90732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UAB7"/>
    <dbReference type="STRING" id="188477.A0A433UAB7"/>
    <dbReference type="OrthoDB" id="5043642at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000248">
        <property type="entry name" value="N-acetyltransferase 9-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039135">
        <property type="entry name" value="NAT9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256:SF16">
        <property type="entry name" value="ALPHA_BETA-TUBULIN-N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256">
        <property type="entry name" value="N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="34"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00069551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS90732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="209" mass="24359" checksum="F944F68F8AF9D980" modified="2019-05-08" version="1">MRDNEFVWVRGTKVLLVPYEKHHVQKYHGWMESEELRELTASERLSLEEEYDMQRKWRESPDKCTFIILARDRYELDTFEDVVQREIGAMVGDVNIFFPSEDISRDEGEVEIMIADPSVRGKGFGRESLCLMMRYARENLGTKTFTSKIGFSNAASLHLFQSLGFKEISRSDVFEEVTLQLEESATDVVFKFTENYHIESMSKSSPLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UDK4</accession>
    <name>A0A433UDK4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Snurportin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_000317</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the snurportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000004">
        <property type="protein sequence ID" value="RUS91915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UDK4"/>
    <dbReference type="STRING" id="188477.A0A433UDK4"/>
    <dbReference type="OrthoDB" id="10003593at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061015">
        <property type="term" value="P:snRNA import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017336">
        <property type="entry name" value="Snurportin-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047857">
        <property type="entry name" value="Snurportin1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13403:SF6">
        <property type="entry name" value="SNURPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13403">
        <property type="entry name" value="SNURPORTIN1 RNUT1 PROTEIN RNA, U TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21974">
        <property type="entry name" value="SPN1_m3Gcap_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Snurportin-1 m3G cap-binding" evidence="11">
        <location>
            <begin position="123"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="317"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="37"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="326"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="391"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS91915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="405" mass="46380" checksum="F9DA7CF624979AE4" modified="2019-05-08" version="1">MSYNRGYDGYGYDDRRGYSGGGWGDDYRGGGGWNDGYRGRYDDGSDRGWDRGRDRNRDRGNYGDGDRRDRDRSFGGRGGGGRGGFNKRGAGGNRGNKRPGSGSSGPPKKIKDDNNWEHADRHQVMQSVYMEAKPENFESEWMFAVCPTGRRRVIVAADETTQSYNSSGTSDAKFKSCLPSGSEAFHEVHKLQDLTVLDTMFDSEAKKCYIIDMMHWRHYPYYDTEADFRFYCLADKYSELKKPTEITENNEVVFLLNFCFSAISRMPNFCKFTDFHHSWQVEGLLFINKTSLYEPKDTSNSLWLRLDKMEEILGFAPPEGLEFEETSSRDERKKKELEERQKLKEQRDAVTKEAQEQLQEDQADATSADKDDNNSENPQGNDDAKTDFTTEDYTTSGAEGNDNWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z3N8</accession>
    <name>A0A3S0Z3N8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_022182</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001501">
        <property type="protein sequence ID" value="RUS70057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z3N8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS70057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="241" mass="27770" checksum="5645E0BCF9BB6BA8" modified="2019-04-10" version="1">MKSVYVITVLQLIDELKSAYIGMKLQIVFSSNMKSVYVITVLQLIDELNSAYIGMKLQIVFSSNMKSVYVITVLQLIDELKYAYIGMKLQILFSLNMKSFYVITVLQLIDELKSAYIGRQESCQLQDLLDCLFQQQSLGNVLLVEAADTQSRSTVRIGHTSPQILIRQRPIEHWETMCRCTVCAAHKISPGTKAVWKCRSCMLITIVSQHSRSIGPRWMEWLMHWRKWMQLLIEGTCIGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z4C9</accession>
    <name>A0A3S0Z4C9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_021812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001412">
        <property type="protein sequence ID" value="RUS70422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z4C9"/>
    <dbReference type="OrthoDB" id="6208413at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS70422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="182" mass="20690" checksum="B4CF52AE45A0A2D4" modified="2019-04-10" version="1" fragment="single">MVKDAVSWREAKERCVHRYNGNLIKITSSVMNDAINKLVIPPSTGYWIGLSNIRLRHLHYDEFSWLDETKSATYMNSFKTPLAPSTGDEWCVITEPGDYWHKTKCYPDKHEFICQKISARNPGPPSLSFKFSHGHRHAYIGYDLHAQCSAFTELGASVKFRMEDNINLTEIGSQGVGYTSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z4I2</accession>
    <name>A0A3S0Z4I2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4549 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_021713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001390">
        <property type="protein sequence ID" value="RUS70525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z4I2"/>
    <dbReference type="OrthoDB" id="76966at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040401">
        <property type="entry name" value="CCDC162"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33331:SF13">
        <property type="entry name" value="COILED-COIL DOMAIN CONTAINING 162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33331">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS70525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="669" mass="75798" checksum="D80DF86277FABBA0" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z4T2</accession>
    <name>A0A3S0Z4T2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl-CoA hydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_021527</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001350">
        <property type="protein sequence ID" value="RUS70707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z4T2"/>
    <dbReference type="STRING" id="188477.A0A3S0Z4T2"/>
    <dbReference type="OrthoDB" id="410701at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000072">
        <property type="entry name" value="Enoyl-CoA hydratase domain-containing protein 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000001">
        <property type="entry name" value="Probable enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF171">
        <property type="entry name" value="SD19268P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS70707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="20609" checksum="3A19FBBD85D7A7C4" modified="2019-04-10" version="1">MPLHKMYGYGNMLRRAVTDLQNLPMPTIAAIDGAALGGGLEIALGCDMRVAASNAKIGLVETSLAIFPGAGGTQRLPRLVGPSVAKELIFTARRLNGWQALEKGVVNHCVDQNEAGDAAFHRSLELADEILPNGPIGVKMAKLAINHGMEVDIETGMAFEAAYYARVIPTEDRMEGLRAFKEKRKPKFKGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z589</accession>
    <name>A0A3S0Z589_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">acireductone dioxygenase (Fe(2+)-requiring)</fullName>
            <ecNumber evidence="10">1.13.11.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_022590</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16723"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.54" evidence="10"/>
    <dbReference type="EMBL" id="RQTK01001613">
        <property type="protein sequence ID" value="RUS69652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z589"/>
    <dbReference type="STRING" id="188477.A0A3S0Z589"/>
    <dbReference type="OrthoDB" id="1867259at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010309">
        <property type="term" value="F:acireductone dioxygenase [iron(II)-requiring] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004313">
        <property type="entry name" value="ARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418:SF0">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03079">
        <property type="entry name" value="ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0533">Nickel</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS69652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="183" mass="21208" checksum="3516E3B161246544" modified="2019-04-10" version="1">MVLAWYLSETVENPNLLNRPEDARIVVMCELHFLGVEAMRFAITETACDPSFMCMRMFKDFHFDKEVTLSKGVSEEGDKLVDEYAREHIDIDHEGMMVQEGGGFYDIREQNDRWIRMEVKPGDMLIIPGGAYHRFILDENNHMKGISLSRVPPGDDTTVYRPQADNHDVRKQYAQRLVCTRCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z626</accession>
    <name>A0A3S0Z626_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_020772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001207">
        <property type="protein sequence ID" value="RUS71457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z626"/>
    <dbReference type="OrthoDB" id="8952144at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS71457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="164" mass="18847" checksum="45B7B6908FD71AD0" modified="2019-04-10" version="1">MPDQFSPYPKTRIIDCTELSRHLRRLQDIHSMAAERIRKVAQQREAPQARGVRLNPGDLVLVRQNLPGRTKIQDLWGEIVHVVVSTPPAEGGPFVIRPRDEEGPIRRVTGSQLRLYHEPTDRIISSCIPDENINDTNSFKEIDRPVPLPRKSLRFHKTPVRLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z635</accession>
    <name>A0A3S0Z635_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_020760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001205">
        <property type="protein sequence ID" value="RUS71474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z635"/>
    <dbReference type="STRING" id="188477.A0A3S0Z635"/>
    <dbReference type="OrthoDB" id="2161379at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042453">
        <property type="entry name" value="WDR53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44666">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44666:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="7"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="235"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS71474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="351" mass="38883" checksum="224C55ACB2BD128B" modified="2019-04-10" version="1">MTTTKLSGGHTASVLTLCAQTKTNQLVSGGEDGTLCVWSDDGRLAAKFNKPGVECTSVLFSKEKPNLIYASFGEEILGLDSLRLTEPVFVFKSNQDEVNQIALDPKEEFLAACDDGCEIKIYGLLDRKVFKTLRYQHTNICSTTLFRPNRKWEIFSGGLDCRFVHWDFSKPKCLRQLNMQEIQTASGDESYMLNPPFIHHISSSPDGNSYALALENGKVPILDGKGKYLQPQYTLNAHGQGVSQVHFLSESTLISAGNDCVVTQWDLSKAECSQHGLFDDHISTDSSESNHKDEKCQAITQACKVHSYQHPSKINWLAVDRIEDNSSTGNGNTCRLFVADQTTDISVLNVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z9B0</accession>
    <name>A0A3S0Z9B0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_022478</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001584">
        <property type="protein sequence ID" value="RUS69757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z9B0"/>
    <dbReference type="STRING" id="188477.A0A3S0Z9B0"/>
    <dbReference type="OrthoDB" id="302770at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12689">
        <property type="entry name" value="RRM1_hnRNPL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12694">
        <property type="entry name" value="RRM2_hnRNPL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12424">
        <property type="entry name" value="RRM3_hnRNPL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12427">
        <property type="entry name" value="RRM4_hnRNPL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000072">
        <property type="entry name" value="heterogeneous nuclear ribonucleoprotein L isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006536">
        <property type="entry name" value="HnRNP-L/PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055204">
        <property type="entry name" value="HNRNPL_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021790">
        <property type="entry name" value="PTBP1-like_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01649">
        <property type="entry name" value="hnRNP-L_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15592">
        <property type="entry name" value="MATRIN 3/NUCLEAR PROTEIN 220-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22976">
        <property type="entry name" value="RRM_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13893">
        <property type="entry name" value="RRM_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11835">
        <property type="entry name" value="RRM_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="31"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="123"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="319"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="212"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS69757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="527" mass="57578" checksum="9EC0C912F54B2455" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZIG1</accession>
    <name>A0A3S0ZIG1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">45 kDa calcium-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Stromal cell-derived factor 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_012592</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000437">
        <property type="protein sequence ID" value="RUS79645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZIG1"/>
    <dbReference type="STRING" id="188477.A0A3S0ZIG1"/>
    <dbReference type="OrthoDB" id="9978834at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
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    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:calcium-ion regulated exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="EFh_CREC_cab45"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="CAB45_EFh"/>
    </dbReference>
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        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827:SF98">
        <property type="entry name" value="45 KDA CALCIUM-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827">
        <property type="entry name" value="RETICULOCALBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="153"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="192"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="344"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023817"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00031511"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS79645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="418" mass="47832" checksum="1EE64E6A7AB3F799" modified="2019-04-10" version="1">MKIIRMVRYYKSQCLFISVALVLCLMCLALVVSGPVRKFPKVEKEEGGLLNDVLLGGNHAGAADGALKDSEVEKLQQHQQLHRPHGLDDEIDVKFENALKLVGGGKLDAKQLEPADHLDVVKMEHDGHVNREYHKEMFLGEEHEEFKSHPVDRAEGRLKEIVAKADLDEDGSLSQPEMEKWIAQKMKEHFDEAKRENEHIFKHLDPDGDGFIKWKEYYVHFLLSRGFDMDSALQHVQNSDGNVGLKQADEDALVSYKFRWADADNNPSDNELSKEEFMVFRHPEHSQQSLDNLVMNVLRGLDANNDNIVTEEEFSALPPGEVENEEYRKMDLKWQAERKQEFRETMDLDHNGKVDKKELRNYLDPTNPLQAKLEADSLISLIDDDKNGLLSMGEILKHSDLFISSKVVNLAANMHEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZJA2</accession>
    <name>A0A3S0ZJA2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyrosine-protein kinase ephrin type A/B receptor-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_011981</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000402">
        <property type="protein sequence ID" value="RUS80252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZJA2"/>
    <dbReference type="STRING" id="188477.A0A3S0ZJA2"/>
    <dbReference type="OrthoDB" id="6142502at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47236:SF4">
        <property type="entry name" value="GENE 9195-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47236">
        <property type="entry name" value="GENE, 32742-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS80252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="630" mass="62660" checksum="95DEF9F0C00D3F06" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZJS7</accession>
    <name>A0A3S0ZJS7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Microtubule-associated protein 10 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_011691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000385">
        <property type="protein sequence ID" value="RUS80551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZJS7"/>
    <dbReference type="OrthoDB" id="69809at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097431">
        <property type="term" value="C:mitotic spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032467">
        <property type="term" value="P:positive regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039302">
        <property type="entry name" value="MAP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21831">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21831:SF2">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14924">
        <property type="entry name" value="MAP10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="726"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="745"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="858"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS80551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="870" mass="96895" checksum="58D8F59AC9E2EC53" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZKY4</accession>
    <name>A0A3S0ZKY4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_022436</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001571">
        <property type="protein sequence ID" value="RUS69803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZKY4"/>
    <dbReference type="STRING" id="188477.A0A3S0ZKY4"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028440">
        <property type="entry name" value="TRPS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47034">
        <property type="entry name" value="ZINC FINGER TRANSCRIPTION FACTOR TRPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47034:SF1">
        <property type="entry name" value="ZINC FINGER TRANSCRIPTION FACTOR TRPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="456"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="154"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="226"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="248"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="376"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="403"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS69803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="508" mass="55381" checksum="BAC37CC28A3F82C4" modified="2019-04-10" version="1">MHHHPHPQDHLNHHTNGNANNNSSSSSSNNHPHHRNSPHPSSHHDAPSAANGRGHNSDNGVDVVSTTSSGSRRGSTVGDGNESGMGGGIGGGIGTRGGTDSVSVPRTSSRSYSPEDARSDSEPIPGGKDDKEGSAAFNRSLSSDEGLSPDEENDGGHRRSRDRGDGRYHSNRKLGSNAGSDDDDMMGGRMRRLSDDEDDIRPEDDDDTDVDERYVTDKGGYSRGRRYSDERDMDRDRDRNKGSRNRSRSFERERDRNRRDLVSRDRKRSHSGSLKGSGLEYMSEDSLLRESRAALHERREGSPRNHRGSPLNLKDGNACTNGGSTGINNDDDFLDPNMSGCGGGGSGGSSSNNGGGGGSSHDTALLRPPKRHIERQNLNTRMIPSSSSRKQRHPMRRFSSAGSEQESPQSSTPSTTIGQHSSTPSHLPVSSTTVEATLERSDSELVTFLLKEGSVYKCVHCHMIFEDASLFLLHNGFHAHDEPFRCVVCHHVCKDRVDFNCHLTSHIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZMC4</accession>
    <name>A0A3S0ZMC4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_009838</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000288">
        <property type="protein sequence ID" value="RUS82386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZMC4"/>
    <dbReference type="STRING" id="188477.A0A3S0ZMC4"/>
    <dbReference type="OrthoDB" id="9633948at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045095">
        <property type="term" value="C:keratin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS82386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="131" mass="14915" checksum="770B15A124C38D54" modified="2019-04-10" version="1" fragment="single">KSRTCRSTLCITRTCRSTLCIPRTCRSTLCTPCTCRSTLCTPRTCRSTLCTPRTCRSTLCIPRTCRSTLCIPRTCRSTLCIPRTCRSTLCRPRTCRSTLCTLRTCRSTLCRSRTCRSTLCRSRTCRSTLCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZND1</accession>
    <name>A0A3S0ZND1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Retinol dehydrogenase 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_009190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000260">
        <property type="protein sequence ID" value="RUS83051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZND1"/>
    <dbReference type="STRING" id="188477.A0A3S0ZND1"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05327">
        <property type="entry name" value="retinol-DH_like_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="339"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="350"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS83051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="43031" checksum="579BE40E737FF199" modified="2019-04-10" version="1">MAGRNKAVDDFFANMPDPDAIFQSWWPWVFAFGSGSLYGLRQWLRGPKCTGGNKLHGKTIIVTGASSGIGKEIALNFAKRGGNVVMACRDEVTGKEAADFVRKETENMDVYFSKLDLNSFKSIRDFVERFKKKEKRLDILVNNAGVMMCPQGLTEDGFDIQFQTNYLGPFYLTELLLDILKESAPSRIINTTAAAQNLGDIDFDDINFENRDYNAGDSYAQSKLAVVVHTFQLAERLKDTKVMCNVVNPGICNTDIYRHLPLKQKKFIRISFGPFMYFLMKMAEDGAQLSVYCGTTDEMAEVTGKHYKDCKEEKVNEKAYDKEFQEKLYKESLKWIKSSGTAIGGGDNLKLTDSDKKEEEKKVTQRKPKVAQSVMERVSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZPH8</accession>
    <name>A0A3S0ZPH8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sorting nexin-17/31 FERM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_012518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000432">
        <property type="protein sequence ID" value="RUS79710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZPH8"/>
    <dbReference type="STRING" id="188477.A0A3S0ZPH8"/>
    <dbReference type="OrthoDB" id="5772781at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000145">
        <property type="entry name" value="Sorting nexin-17 isoform1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040842">
        <property type="entry name" value="SNX17/31_FERM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12431:SF14">
        <property type="entry name" value="LD15323P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12431">
        <property type="entry name" value="SORTING NEXIN 17 AND 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18116">
        <property type="entry name" value="SNX17_FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sorting nexin-17/31 FERM" evidence="2">
        <location>
            <begin position="2"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS79710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="176" mass="20108" checksum="62D617FC429B1A98" modified="2019-04-10" version="1">MVKEGSFRITRMRCWRITTIYPNGNGLSSSSERDNAQLELSFEYLMSKDNLQWVSIISDQAMLMSMCLQSMVDELIMKKKGKKFKKPQDRLRTARNGGPFRPVSRELSQGTEVRHSKEQNNNTRVQVVRAHLPEDQSAINKAMGSVKKQLSKGLQHKEEETITENDAFEGIGDDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZQ51</accession>
    <name>A0A3S0ZQ51_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF19 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_012011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000404">
        <property type="protein sequence ID" value="RUS80215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZQ51"/>
    <dbReference type="OrthoDB" id="6161141at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018576326" description="DUF19 domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS80215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="32589" checksum="30EEC802D57A6575" modified="2019-04-10" version="1">MDYFSFLLAALLSLAIGRVSPMSDNCQKLGLCSSSHDPMTMTGRTERECQEMKKVVSCYDKYVDLCDIPFKVERVRHSNGILKQRLAASCVTNKDRGLISPDSASCHHLVQCVAMTSGPTMKDHQDDMCRSLEKAVGCFDLYLPRCDNQAIVAGFRGTIDQLRHKLMTTCDKDHKKAVPVARYSFMRAPPSECDKQFRACLTPEFLHASEHKNYTRLCNAAAGVFPCLERVLEDRVCQSVRDKDRSELRTHIDILRGDIDPGCIDTAWPSSSVSVFLLLVCMALTQLHICG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZY06</accession>
    <name>A0A3S0ZY06_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">EGW08_003445</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">EC2010</strain>
            <tissue evidence="19">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 21">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="EMBL" id="RQTK01000073">
        <property type="protein sequence ID" value="RUS88815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZY06"/>
    <dbReference type="STRING" id="188477.A0A3S0ZY06"/>
    <dbReference type="OrthoDB" id="2413561at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010976">
        <property type="term" value="P:positive regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF614">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000615">
        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="435"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="140"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="241"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="331"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="545"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="471"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="486"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="697"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="552"/>
            <end position="559"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 14">
        <location>
            <position position="579"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="625"/>
            <end position="631"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="701"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="702"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RUS88815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="758" mass="83826" checksum="A4EC902FF89209A8" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZYW5</accession>
    <name>A0A3S0ZYW5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_013642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000500">
        <property type="protein sequence ID" value="RUS78607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZYW5"/>
    <dbReference type="OrthoDB" id="5945826at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018676361" evidence="1">
        <location>
            <begin position="24"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS78607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="541" mass="60870" checksum="C84F4CB67610E78D" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZZ95</accession>
    <name>A0A3S0ZZ95_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_013366</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000485">
        <property type="protein sequence ID" value="RUS78861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZZ95"/>
    <dbReference type="STRING" id="188477.A0A3S0ZZ95"/>
    <dbReference type="OrthoDB" id="5951059at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016907">
        <property type="term" value="F:G protein-coupled acetylcholine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15329">
        <property type="entry name" value="7tmA_5-HT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000995">
        <property type="entry name" value="Musac_Ach_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF199">
        <property type="entry name" value="IP13425P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00243">
        <property type="entry name" value="MUSCARINICR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="24"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS78861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="201" mass="22398" checksum="8D68061273DF4FD1" modified="2019-04-10" version="1" fragment="single">PYEDWQFVIVAIILGLLIFCTVVGNSLVCISVGLVKRLQSPSNLLIVSLAVADLFVGLLVMPYAAVYELYGSWVLGPFICDMWTTTDVLLCTASILNLCAISVDRYFVITRPFQYAIKRTPKRMGITVLIVWSVSAVVSIPPVFGWKTPSPPFECMISSDIGYQIYATLCAFYLPLTVMICVYFRIWRVSSKIAKAEAKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A1E4</accession>
    <name>A0A3S1A1E4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_000833</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000012">
        <property type="protein sequence ID" value="RUS91403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A1E4"/>
    <dbReference type="STRING" id="188477.A0A3S1A1E4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS91403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="335" mass="38617" checksum="BBE26CB4D51159BA" modified="2019-04-10" version="1" fragment="single">SSTIDFCTNNTVNPCHQDLYSSTIDFRTNNTNIQSHQDPYSFTIDFRTNNTNIQSHQDPYSFTIDFRTNNTNIQSHQDLYSSTIDFCTNNTNIQSHQDLYSYTIELCTNNTVNPCHQDLYSSTIDFRTNNTNIQSHQDPYSFTIDFRTNNTNIPSHQDLYRFTIDFCTNSNVIQSHQDLYSSTIVFCTNRTNIQSHQDLYSFTIDFCTNNTNIQSHQDLYSSTIDFYTNNTDIPCHQDLYSSTIVFCTNSTVIPSHQHLYRSTIVFCTNRTNIQSHQDLYSSTIDFCTNNTNIQSHQDLYSSIIDFCTNYTITTSHQGLYSSSTSVPTTLSSKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A1R2</accession>
    <name>A0A3S1A1R2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Antistasin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_003838</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000084">
        <property type="protein sequence ID" value="RUS88382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A1R2"/>
    <dbReference type="OrthoDB" id="6038702at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.22.10">
        <property type="entry name" value="Antistasin, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004094">
        <property type="entry name" value="Antistasin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011061">
        <property type="entry name" value="Hirudin/antistatin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02822">
        <property type="entry name" value="Antistasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57262">
        <property type="entry name" value="Leech antihemostatic proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51252">
        <property type="entry name" value="ANTISTASIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018560147" description="Antistasin-like domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Antistasin-like" evidence="4">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Antistasin-like" evidence="4">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS88382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="186" mass="20439" checksum="F2BB0A2EFCC9EEBA" modified="2019-04-10" version="1">MDFKLYHLALIAVLCSLKYSEGYQVAARQCIVPVCAPPPANCFYQSDADECPTCNLVCNPAGCSALRCARPCYNGYIKDDKGCNTCECRPGCYQKPCPFECPHGTYLDRAGCPTCQCKPQPLACHRDVAPLCTRGVCPHVCACEPYCYPSPNDGGLRTGNTVNDFWNMILLRVLSSQRKPNGPSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A6N0</accession>
    <name>A0A3S1A6N0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_008217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000220">
        <property type="protein sequence ID" value="RUS84039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A6N0"/>
    <dbReference type="OrthoDB" id="8196546at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS84039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="132" mass="15215" checksum="774E84F8C3629AD1" modified="2019-04-10" version="1">MGNIPNDGLYGADKQKFVFLDFRVGWLKVFFSIFGSVCSNEKNGMQKPELLQLIQRRKLAYYVHIRRHCSIQKRVVEGKVGGKLGRGRKRQSWLANIQETSQLRLSVACEAALDHERWRRMIAHLGDGTAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AUP5</accession>
    <name>A0A3S1AUP5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Leucine-rich repeat-containing protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_019570</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001034">
        <property type="protein sequence ID" value="RUS72674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AUP5"/>
    <dbReference type="STRING" id="188477.A0A3S1AUP5"/>
    <dbReference type="OrthoDB" id="8436363at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052116">
        <property type="entry name" value="Centro_Cilium_Assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23170:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23170">
        <property type="entry name" value="NY-REN-58 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="318"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS72674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="674" mass="77395" checksum="BEA43AD77588A657" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AXA2</accession>
    <name>A0A3S1AXA2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_017607</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000813">
        <property type="protein sequence ID" value="RUS74627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AXA2"/>
    <dbReference type="STRING" id="188477.A0A3S1AXA2"/>
    <dbReference type="OrthoDB" id="276151at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008119">
        <property type="term" value="F:thiopurine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008854">
        <property type="entry name" value="TPMT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10259">
        <property type="entry name" value="THIOPURINE S-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10259:SF11">
        <property type="entry name" value="THIOPURINE S-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05724">
        <property type="entry name" value="TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51585">
        <property type="entry name" value="SAM_MT_TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS74627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="20582" checksum="6324023112D63C80" modified="2019-04-10" version="1" fragment="single">MCGKTVDMNWLADRGLQVVGLDIALEALVQFMTDSGHNWSAQAAPKLGPTAKLFTRDDGKIKLYCGDAFNFSSALEGQFDAIYDCDGFHSFTGSLFQNMANVMKEVLAPGGRFLLDAVNYDPKMLERDDLNIEAAIPPPYPVTVEAMRNAFEPECEVELLETHIETKVFCLTETPFNAYLVKKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AXF8</accession>
    <name>A0A3S1AXF8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_017496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000803">
        <property type="protein sequence ID" value="RUS74745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AXF8"/>
    <dbReference type="STRING" id="188477.A0A3S1AXF8"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS74745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="243" mass="26534" checksum="3B996DA2B24C2E32" modified="2019-04-10" version="1">MSLVSLDFSHNEFSVLGGIHLGGALGANEGLVDVDLSWNCLRKDGAAAIANSLRLNRTLEVLDLSWNGFGVEGAAALARSLPVNTTLKVLDLTNNRFDCKAAQKLAPGLKKNRSLETLILSMNPLGELGVESILKALTGHPTVRFLGLEEIGLSRASVATIQQLEQKLGMIVVHGGLNGHDRTTRFMDMLLENMDCTHQGHIDYRSILSGEAFSEHSRRRPSRGFHLLDRANLEDPDSDDDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B183</accession>
    <name>A0A3S1B183_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_019767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001062">
        <property type="protein sequence ID" value="RUS72485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B183"/>
    <dbReference type="OrthoDB" id="6195989at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018602462" evidence="1">
        <location>
            <begin position="26"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS72485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="105" mass="11690" checksum="0BDA75085BF286DB" modified="2019-04-10" version="1" fragment="single">MAAHNAWILCLHLLVVIDLIPGFSAQSTSVAENAYDSLTKLNCTHFKAIIEAASLQQRYKSTSPLTVFVFVDAAYNRLPPYMINNLYDRSSINNQGASEYVNSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B284</accession>
    <name>A0A3S1B284_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit K</fullName>
            <shortName evidence="5">eIF3k</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">eIF-3 p25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_018996</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit K family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000961">
        <property type="protein sequence ID" value="RUS73237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B284"/>
    <dbReference type="STRING" id="188477.A0A3S1B284"/>
    <dbReference type="OrthoDB" id="337745at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000212">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.250:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.250">
        <property type="entry name" value="ARM repeat, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03010">
        <property type="entry name" value="eIF3k"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009374">
        <property type="entry name" value="eIF3k"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016020">
        <property type="entry name" value="Transl_init_fac_sub12_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="40"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00057041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS73237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="217" mass="24556" checksum="F5DAE6053B119FC8" modified="2019-04-10" version="1">MAEAMRATVASLLKGIERYNPENLVNLQRYVDMQANENTYDLEANLAVLKLYQFNPNLYQAEVTAVILLKALTNLPHSDFILCKCMIEPGRLLEEPVAKVLVLAELLETANFNEFWITLMKDLDPLVEGIVGFEDSIRKFVCHVVASTYSTIRKDKLRQLLGNVTEAQASQWVSKYGWTEQLDGYVFIANQDETIRTKNITEKISFDSVAAIMASGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B390</accession>
    <name>A0A3S1B390_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_017216</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tumor necrosis factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000777">
        <property type="protein sequence ID" value="RUS75035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B390"/>
    <dbReference type="OrthoDB" id="6074301at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005164">
        <property type="term" value="F:tumor necrosis factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006052">
        <property type="entry name" value="TNF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11471">
        <property type="entry name" value="TUMOR NECROSIS FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11471:SF24">
        <property type="entry name" value="TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00229">
        <property type="entry name" value="TNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50049">
        <property type="entry name" value="THD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="THD" evidence="6">
        <location>
            <begin position="160"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS75035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="334" mass="37362" checksum="CFD202BC2AE5B7E0" modified="2019-04-10" version="1">MTTKLHSQCETNAAFLQNGGSDSEVGITLKKPDKNRMLGWLAVLLSTLTLAMVLALGIVVFNFSDKVQRELFTAQQSTLDVVTPYACIPCSKLLRDPADVVESDPLLQQLEITDKDGTDVCCAYSPLQVTALFESIVRLNDPPNLSLASFNASDFTFSPVSAHKRLYADHFSQDLGVIDFPQRSQICELKEDDDRYYGLEHHRGVNLTKHGLKIVHGGLYYVYSSIKFRPHTSAPCREFEYQTFNAFVEKVSLRRRGSQNILQFSHTCCDDCMKIQETGYTGGVFVLDPGDVVRVRVTGFRLVHFEAETSFMGLAMLGSPSENNINKIKDLKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B3D3</accession>
    <name>A0A3S1B3D3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Replication protein A C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_017098</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000768">
        <property type="protein sequence ID" value="RUS75135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B3D3"/>
    <dbReference type="STRING" id="188477.A0A3S1B3D3"/>
    <dbReference type="OrthoDB" id="25571at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04478">
        <property type="entry name" value="RPA2_DBD_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000168">
        <property type="entry name" value="Replication protein A 32 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040260">
        <property type="entry name" value="RFA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014646">
        <property type="entry name" value="Rfa2/RPA32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014892">
        <property type="entry name" value="RPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989">
        <property type="entry name" value="REPLICATION PROTEIN A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989:SF16">
        <property type="entry name" value="REPLICATION PROTEIN A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08784">
        <property type="entry name" value="RPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036949">
        <property type="entry name" value="RPA32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Replication protein A C-terminal" evidence="8">
        <location>
            <begin position="174"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)" evidence="6">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)" evidence="6">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR036949-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS75135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="254" mass="28054" checksum="22536A07D6668DD2" modified="2019-04-10" version="1">MWNQDFNQSGFSQVQGGGFSTPQGDEKKKSKRSNNIVPVTVAQILTAKHEDDAFMSGNQELSQVTLLGLIKSVNESPTRIDYVIDDMTGPPLDVRRFNDTDENEEAETQTQNVYAPNTYVRVNGLLRAFGGKRTVNAFKISPVTDMNELTCHMLEVIHASASGQQQHAQPIKSSSMGSNSMDMVEQIAGLSPLQMQVQTIIRSDHSEQGCSVDDICQQLRSVAPKAIRETIEFLSSEGHIYSTIDDEHFQATDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B4H4</accession>
    <name>A0A3S1B4H4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_016435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000710">
        <property type="protein sequence ID" value="RUS75808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B4H4"/>
    <dbReference type="STRING" id="188477.A0A3S1B4H4"/>
    <dbReference type="OrthoDB" id="419768at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070382">
        <property type="term" value="C:exocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042043">
        <property type="term" value="F:neurexin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001565">
        <property type="entry name" value="Synaptotagmin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45716">
        <property type="entry name" value="BITESIZE, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45716:SF2">
        <property type="entry name" value="BITESIZE, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00399">
        <property type="entry name" value="SYNAPTOTAGMN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="76"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="210"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS75808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="316" mass="36134" checksum="917C3F3F763CF6F2" modified="2019-04-10" version="1">MGATSSQPLPGQNPLQQNPEKIEALAKALDVKAERQKQLAIQETWDRLEQDKRSLQVLKSLFKKLDPTVVRSPTDINGEIELAFKYDFKRQLLLVKVIKCRDLHAKDIRTKASDPYVRLQLYPDLHSHGAKVTKIIVETREPVYNEIFAFKMREKELTDTNLVVQVFDYDAVTKDDFLGEVVIELSQFDFVKEPVLAAWYTLHMETDLSITGELEVSLKFLPPQSLFLTIHSASGLSRRRDGHVAQAFVKVSVPGLGAVFKTQVVSEETGNPEWQETFEFELPQEELGFRYVTLLVFQDCIRLCVLFMLSLAVFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B5D6</accession>
    <name>A0A3S1B5D6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_011933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000400">
        <property type="protein sequence ID" value="RUS80295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B5D6"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS80295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="232" mass="24614" checksum="7A663A26B3ACF86F" modified="2019-04-10" version="1">MLTQQLLTAAKFVRNFRQAADKINGWRMEDGGARKSDQTLFSSCQPVAQPPCPQILLSPAQAPIAQTQSQSKSPNHPVLKFSSHQPSLSLSRPATLSSNSPLTSLGPNRQSPSRPSPSLMSQSPKPKSKWPTTMSSNSPPTSPSISRPSPSLSSQPPCPQILLSPTQAQSPKLRSQSPKPKSKSPTTMSSNSTPTSPSISRPSPGLSLSLSRQPPCPQILSPAQVSVAQAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BBM9</accession>
    <name>A0A3S1BBM9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_015403</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000631">
        <property type="protein sequence ID" value="RUS76831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BBM9"/>
    <dbReference type="STRING" id="188477.A0A3S1BBM9"/>
    <dbReference type="OrthoDB" id="248495at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015661">
        <property type="entry name" value="Bub1/Mad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030:SF4">
        <property type="entry name" value="BUB1 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030">
        <property type="entry name" value="MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0137">Centromere</keyword>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="3" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS76831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="205" mass="23790" checksum="336B0D1B05FD3F5D" modified="2019-04-10" version="1" fragment="single">LQNLVNIYKHKAALKDGVEPFACLLTIQLLYLFEQMHACHIIHGDVKPDNFLVAALPDAPQELFNYERPLVKIIDFGQSIDMTMFSPGTTFTAKVETSGFQCIEMKTNRPWTYQTDLFGLAGTIHVVLFGSYMNVFQEHGVWRTTGNFVRKWNTPLWKHLFNSLLNVPSCWELPNLAELRKEFENHFRQNLTAGYSSWIRRLHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BEA7</accession>
    <name>A0A3S1BEA7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_010231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000309">
        <property type="protein sequence ID" value="RUS82004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BEA7"/>
    <dbReference type="OrthoDB" id="6537767at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS82004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="241" mass="26705" checksum="541D29594F98A4C9" modified="2019-04-10" version="1">MCLPVPSEIKLTCNVEMRLPVPSEIKLTCNVEMRLPVPSEIKLTCNIEMGLPVPSEIKLTCNVEMGLPVPSEIKLTCNVEMRLPVPSEIKLTCNVEMRLPVPSEPKLTCNVEMRLPVPSEPKLTCNVEMRLPVPSEPKLTCNVEMRLPVPSELKLTCNVEMCLPVPSEIKLTCNVEMRLPVPSQLRLTCNVEMGLPAHDAPYPLHCGAAPVGSRVGWVLHHLEEQGPVRQLVSAENTEIQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BET4</accession>
    <name>A0A3S1BET4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_010214</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000308">
        <property type="protein sequence ID" value="RUS82023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BET4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS82023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="12877" checksum="E0D6F17285754CAA" modified="2019-04-10" version="1" fragment="single">HIIFSLALAFGIPGSVLVVVTVTSITINPSTVYMAVLSISNSIALITGVQIFKMPNVGKFTIDDMIPMWLCRLFQTFSQWTLALICAERFVSVAFPLKKSQLYTMRTTAVSAGAAFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BFV4</accession>
    <name>A0A3S1BFV4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_009269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000263">
        <property type="protein sequence ID" value="RUS82984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BFV4"/>
    <dbReference type="STRING" id="188477.A0A3S1BFV4"/>
    <dbReference type="OrthoDB" id="680339at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047710">
        <property type="term" value="F:bis(5'-adenosyl)-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
        <property type="entry name" value="Nit1/2_C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF27">
        <property type="entry name" value="DEAMINATED GLUTATHIONE AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="71"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS82984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="319" mass="34821" checksum="7EEA3A47482C6B6A" modified="2019-04-10" version="1">MKLNLILHMKQVCLPRTILPLVYNPHRNLQCQTTRRNSIIKNYQNLRMASTCSTQISNGHGKEGESGGRKAIIGVCQMTSTSVKSDNLRTIADLVASAKAKGSQMVFLPEACDYIGESKQQSVELAESMDGSFITQCRELAVKHAVWLSVGGFHLKAPVDRVDKTKNVHVIIDSAGNVQATYAKTHLFDLSLEGSVQLMESSYVVPGDRVVPPVATPVGRVGLAICYDMRFPELSLTLARQGAEILTFPSAFTQVTGTAHWESILRCRAIETQSYVVAAAQTGKHNAKRSSHGHTMVVGTCIECSDNLCLLHPFPPLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BH34</accession>
    <name>A0A3S1BH34_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 15">Dolichol-phosphate mannosyltransferase subunit 1</fullName>
            <ecNumber evidence="7 15">2.4.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EGW08_011644</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">EC2010</strain>
            <tissue evidence="17">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a di-trans,poly-cis-dolichyl phosphate + GDP-alpha-D-mannose = a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + GDP</text>
            <dbReference type="Rhea" id="RHEA:21184"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 15">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 15">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 15">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.83" evidence="7 15"/>
    <dbReference type="EMBL" id="RQTK01000383">
        <property type="protein sequence ID" value="RUS80589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BH34"/>
    <dbReference type="STRING" id="188477.A0A3S1BH34"/>
    <dbReference type="OrthoDB" id="2603at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000036">
        <property type="entry name" value="Dolichol-phosphate mannosyltransferase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398:SF1">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="16">
        <location>
            <begin position="8"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00014858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RUS80589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="240" mass="27170" checksum="8CEFE07B86D526DD" modified="2019-04-10" version="1">MAERNKYSVLLPTYEERNNLPLIVWLLVKHLSKSGHDFEIIIIDDGSPDGTLDVAKELQRLYGKDKIVLRPREKKLGLGTAYIHGIKHATGNFVIILDADLSHHPKFLPEFIRKQAEKDYDVVTGTRYRGNGGVFGWDLKRKVISRGANYLTQVLLRPGVSDLTGSFRLYKKAVLEKLINACVSKGYVFQMEMIIRARQFNFSVAEVPITFVDRLYGESKLGGSEVVAFFKGVLYLFATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BHW9</accession>
    <name>A0A3S1BHW9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_007959</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000211">
        <property type="protein sequence ID" value="RUS84266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BHW9"/>
    <dbReference type="STRING" id="188477.A0A3S1BHW9"/>
    <dbReference type="OrthoDB" id="6152853at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS84266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="227" mass="25476" checksum="CE4D3D40D07F164D" modified="2019-04-10" version="1" fragment="single">MTEVKFEEVLRGQDLVTSLGTMKINGNVSVERSLFQQGQMVLVLDQDGYVDMGLTGVSCLDDVTTCTGSFNFRITFMLREISMTQNYIITSGGELLESTGVSLYYQHGQLRFWVKRGRMTDRKIFNYPLTENVWYTMDASWDATDGSIAVFIDGNEIAGRKLFSSPTPPTNLTYPIHIGKSPGKNGTTKMNVLLFRFWEKTRTQLINEGCNKTLAVMNPPNPPPTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BJL4</accession>
    <name>A0A3S1BJL4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_007005</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000177">
        <property type="protein sequence ID" value="RUS85244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BJL4"/>
    <dbReference type="STRING" id="188477.A0A3S1BJL4"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="436"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS85244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="532" mass="58147" checksum="39ACC0B6028CE532" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BL06</accession>
    <name>A0A3S1BL06_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_001495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000025">
        <property type="protein sequence ID" value="RUS90784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BL06"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS90784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="224" mass="25307" checksum="3C8F0D57A340E119" modified="2019-04-10" version="1">MTPVSVGLIKLTPIQPVGGEIARARTTDLLRRKPMFYPRATTPSSQRIGEGSNTKSRLRNLSSQGRKERRRKTKKDEERRRKTKKDEERRRKTKKDEEPGFLSVLSPTNFRHEKPSDGSSSSTVTIHQVLLSPGSPYFNPLGHRRCGEVKIIILAEEEGWWVSPMLVQRSRHSQALLIIKFPFPIMPGPEEPIDKTCPSLDGSNLPFDHDGATNTSRWGDGQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BMH9</accession>
    <name>A0A3S1BMH9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_005160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000120">
        <property type="protein sequence ID" value="RUS87084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BMH9"/>
    <dbReference type="STRING" id="188477.A0A3S1BMH9"/>
    <dbReference type="OrthoDB" id="266020at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050686">
        <property type="term" value="P:negative regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009967">
        <property type="term" value="P:positive regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12377">
        <property type="entry name" value="RRM3_Hu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000205">
        <property type="entry name" value="Sex lethal, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000383">
        <property type="entry name" value="Sex lethal, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002343">
        <property type="entry name" value="Hud_Sxl_RNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00961">
        <property type="entry name" value="HUDSXLRNA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="16"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="102"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="241"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS87084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="337" mass="37799" checksum="662AF385BE580DCB" modified="2019-04-10" version="1">MEDQNDGNFFGDDSSTNLIINYLPQNLTDEEFRSLFLSVGPIVSSKIVRDKATNYSYGFGFVVYERSQDAQRAIETLSGLQLQNKRIKVALARPSGEQIKGANLYVRNLPVQWKETELNKLFDPYGKIIQSRVLIDLATGVSKRVGFVLYDTRDEAENAIKSLSGKTPEGCTEPITIKFADDNTKKIKQQGGQVQYVPIPNFAAPGPMRTQINRFQRFNPMAGNFNGQGPGMTPPNQQGGYTLFVYNIGFQATDRTLWQMVSPFGTVQKVNVMLDHEKNQCKGFGFVTMTNYQEAQNAINCLNGSYYQGRVLQVSFKNANQNMQQVQPPQQQVNLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BN56</accession>
    <name>A0A3S1BN56_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_021310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001303">
        <property type="protein sequence ID" value="RUS70928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BN56"/>
    <dbReference type="STRING" id="188477.A0A3S1BN56"/>
    <dbReference type="OrthoDB" id="5339429at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035329">
        <property type="term" value="P:hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21433">
        <property type="entry name" value="SARAH_Sav"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000035">
        <property type="entry name" value="Salvador homolog 1 (Drosophila)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011524">
        <property type="entry name" value="SARAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030030">
        <property type="entry name" value="Sav"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47522:SF2">
        <property type="entry name" value="PROTEIN SALVADOR HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47522">
        <property type="entry name" value="SALVADOR FAMILY WW DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50951">
        <property type="entry name" value="SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="205"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="SARAH" evidence="4">
        <location>
            <begin position="336"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS70928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="45085" checksum="0E6F1B0509485162" modified="2019-04-10" version="1" fragment="single">MTSSPVSRTDITSTVSQSFGVAYSQPVGGGGVGVVSSVPRLMMHPSQMHGVRNTVGVSGNSFLDSQQHPHQSGGVLVRNPAESEVISLEDQRPFHNMPQSGLSVIREDDNPEAKPYFKYVGASSENKEPLVSQQQQQQSDENYQIAQYHEEIRSHYAQQNPGGNLLGKGMFGMVASDLSDLKTPSTTSSVNTSGAGSYLSQEESLPLPAGWSVDWTVRGRKYYIDHNTQATHWSHPLKKESLPAEWERIESKERVLFNSFFFLSSHVTRTAQYHHPCSNVQGMVLSYGGSVVPERIPAHLEMRQSKQLVPANPYLNTEIPEWLVVFSKAPHEHDHKLKWELFTLKELENFAGLLIRLHKQDLEHIVMSYERYRIALTREMERRKAEKQQQQQQQQQQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BPQ2</accession>
    <name>A0A3S1BPQ2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_003753</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000081">
        <property type="protein sequence ID" value="RUS88495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BPQ2"/>
    <dbReference type="OrthoDB" id="6161073at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS88495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="249" mass="28316" checksum="06DCBDBB761F9035" modified="2019-04-10" version="1" fragment="single">SLRRVVTTLQIESLRRVVTILQIEGLRLVVTILQIEALRLVVTILQIEALRLVVTILLQIEGLRRVVTILKIEGLRRVVTILQIEGLRLVVTILLQIEGLRRVVTILQIEGLRRVVTIFLRLVVTILQTEGLRLVVTILLQTEGLRLFVTILQIESLRLVVTILLQIEALRLVVTILQIEGLRLVVTIMQIEGLRLVVTILQIEGLRLFVTILQIEGLRLFVTILQIESLRLVVTILLQIEALRLVVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BQK0</accession>
    <name>A0A3S1BQK0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sushi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_003119</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000065">
        <property type="protein sequence ID" value="RUS89111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BQK0"/>
    <dbReference type="OrthoDB" id="6043768at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0768">Sushi</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018674465" description="Sushi domain-containing protein" evidence="5">
        <location>
            <begin position="24"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="14"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="128"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS89111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="189" mass="21568" checksum="3D6F8946C244936A" modified="2019-04-10" version="1">MYTYILLVFGASLIFCSSPLVAAACLGLKIPSDVHLLTPLRSFYQTGATFDIVCVPGYGNDTIVQLRCDISGEWHGHWPDCSKKEEKARWWMFLLGMVALVVLVPCILPRLYFTYIDTSSPRKDWLINKRRKSSKKMSDTIRMPNISSQPAHRSTATESRNPQGMYPMPLPPIRRHREHSVNYNEHAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BR03</accession>
    <name>A0A3S1BR03_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_019447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001018">
        <property type="protein sequence ID" value="RUS72787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BR03"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS72787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="114" mass="12978" checksum="554843C71AD011E3" modified="2019-04-10" version="1" fragment="single">MYTALSRQVKRMHRRMSIALLVFTITVIIVFNESARPIWIRSITDSVSGLMDPTQLYKRTDIDINANDVLVAVNIPRAGMLHLTDHIVRHAILIITYSITTIITIIIIIIIIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BR27</accession>
    <name>A0A3S1BR27_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_019385</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001009">
        <property type="protein sequence ID" value="RUS72848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BR27"/>
    <dbReference type="STRING" id="188477.A0A3S1BR27"/>
    <dbReference type="OrthoDB" id="419455at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11969">
        <property type="entry name" value="MAX DIMERIZATION, MAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11969:SF99">
        <property type="entry name" value="MAX-BINDING PROTEIN MNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="78"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="15"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="201"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="318"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="654"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="654"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="666"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS72848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="887" mass="92303" checksum="8D3ABE8401D979A5" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BRU9</accession>
    <name>A0A3S1BRU9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein FAM221A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_002344</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM221 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000045">
        <property type="protein sequence ID" value="RUS89903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BRU9"/>
    <dbReference type="OrthoDB" id="310364at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026755">
        <property type="entry name" value="Fam221a/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31214:SF2">
        <property type="entry name" value="PROTEIN FAM221A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31214">
        <property type="entry name" value="PROTEIN FAM221A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14753">
        <property type="entry name" value="FAM221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="301"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00039630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS89903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="345" mass="37992" checksum="735CC0963061F9D5" modified="2019-04-10" version="1">MAGSQYNLKFGGNAGASVDAYLEYRRIVGDDDGGNMFTPEEYEAYKRKVIPQRIKNRIYTCYSNPAGMDCKLIGPETPCFCTHRYKQHETDFAEIPSERPIKLRCKVSGCLCSSYHYVPLNGSQSIRCTCKHLAEEHKAKAPYVCKRGGCTKCTGFKSSFTCSCGNTHNEHQMIIETAEEREARGHPLGEAVPFQAMGGITGFSSLAEGYLRLDPSGRGAPSEEFLNQPITALDGPFLRANVNSIKAHHMAKTGGKAAITGPEDRVFEDMEERISAAKKEGESDMDYFERRYQERLKLEAAAKRKSIPNPYGPGSTSKTGVRKALEPSSSRTKSSKGPNPGSSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BT26</accession>
    <name>A0A3S1BT26_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_004153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000093">
        <property type="protein sequence ID" value="RUS88100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BT26"/>
    <dbReference type="STRING" id="188477.A0A3S1BT26"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS88100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="241" mass="26762" checksum="22BAC0BBE4F4C21B" modified="2019-04-10" version="1">MTPCDNPLSSLRGPNVTTHWPVSHGVISDWPVGCHMGSSQTGQWVVTWGHLRLGSGLSHGVISDWPVGCHMGISERQPQASVAGTCPRWKLYPTTPTPHDPHYPTTPTPHDPHYPTTPTPHDPHYPTTPTPHDPHYPTTPTPHDPHYPTTPTPHDPHYPTTPTPHDPHYPTTPTPHDPHYPTTPTPHDPHYPTTPTPHDPHYPTTPTPHDPHYPTTPTPHDPHYPTTPTPHDPHYPTTPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BX53</accession>
    <name>A0A3S1BX53_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_015049</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000602">
        <property type="protein sequence ID" value="RUS77182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BX53"/>
    <dbReference type="STRING" id="188477.A0A3S1BX53"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005859">
        <property type="term" value="C:muscle myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000003">
        <property type="entry name" value="Calmodulin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF33">
        <property type="entry name" value="MYOSIN LIGHT CHAIN ALKALI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2" id="KW-0518">Myosin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="31"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS77182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="104" mass="11785" checksum="A22A2C0AB989C7AB" modified="2019-04-10" version="1" fragment="single">STIRPPAGEKAYKLEEFLPIFSAVQKEKDTGTFADFNEAFKTFDREGQGFISAAEMRHVLTCLGEKLTDDEVDEVMVATDTREDLEGNIKYDDFIQKILKGPFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C494</accession>
    <name>A0A3S1C494_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase M12B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_009653</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000280">
        <property type="protein sequence ID" value="RUS82579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C494"/>
    <dbReference type="STRING" id="188477.A0A3S1C494"/>
    <dbReference type="OrthoDB" id="5855429at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF256">
        <property type="entry name" value="PEPTIDASE M12B DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12B" evidence="10">
        <location>
            <begin position="196"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS82579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="476" mass="53709" checksum="926617F325DDD5F9" modified="2019-04-10" version="1" fragment="single">SGEGLQLPKPSGEGLQLPKPSGEGLQLPCRARRTEIVFPRVESSAGTLTFATLADDDIKRKSLLQATLTWRRRKLHVILYQNQVTSHQMHSEWTEGNLTYALTSHKDCFYRGYVKGQRSSYAALSACEGLTGIIQTEDELLYIQPANRSMGTDDLHLAHILYTCEARQQASAEPDWGMGSTARHIGRRRRAASRPRYLEVLVAVDPTVVNELGSKERTQDYVMVLMNIANTVYQHHTLGVDIKVVVVKIIFLTKRQQGQVLTRNDAYRTVTQFCEWSSRQIPIGQPPHFDISVLITKEVLGPSGYAPITGLCNPGRSCAAVREEGFSTGFIIAHEMAHVFGLFHDGHGNNCHGPEFQNAMMASLVESKLNRFWWSSCSSQRMKDMVPYLHCLHNEPAVRMPNHYPLESPAEFSPELGRPYSLDFQCKMEFGTYFRMCPHIYSDPCHTLWCSASSQRYMCRTKRGPPMTGSQCGYQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C6D6</accession>
    <name>A0A3S1C6D6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_008049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0489 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000214">
        <property type="protein sequence ID" value="RUS84209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C6D6"/>
    <dbReference type="STRING" id="188477.A0A3S1C6D6"/>
    <dbReference type="OrthoDB" id="418142at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024131">
        <property type="entry name" value="UPF0489"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13225">
        <property type="entry name" value="MISEXPRESSION SUPPRESSOR OF RAS 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13225:SF3">
        <property type="entry name" value="UPF0489 PROTEIN C5ORF22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12640">
        <property type="entry name" value="UPF0489"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS84209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="250" mass="28217" checksum="D2B3C85E41BE7DB9" modified="2019-04-10" version="1" fragment="single">MGDSKKKKDLLQVHIVEQHNDAVPPIHRAIASRLLPFSCAAMVHLDSHPDLLIPVHMQADTVFKPAELYESLSIENWILPLVYAKHFDHIVWVKPPWARQIPVSKQRFLVGQCVESGCVRVTSKENYFLTDGLFRPGSELSEPGVLTLQVEEVLPAAWADLDPTYASSESVSKQTELTQGQAPSWVDSIQDSLKDKPYVLDIDLDFFSTANPFRDLIEPTAEQALKRLYHYTTPSNFSDESIASFTKTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H3V4</accession>
    <name>A0A3S1H3V4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_020545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001174">
        <property type="protein sequence ID" value="RUS71687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H3V4"/>
    <dbReference type="OrthoDB" id="4473401at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036645">
        <property type="entry name" value="Elafin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00095">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57256">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51390">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WAP" evidence="2">
        <location>
            <begin position="34"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="440"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS71687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="477" mass="52409" checksum="9B9AA146A9F8F1BB" modified="2019-04-10" version="1">MGLPDRTANLPLEGSDSTTSASSHQRMHVVMGLAHAQSDFLCPPNNKMGLCEPVPNTCFHDQDCPADHICCPEACTRSCKPKMAPGQRSQPDVPDLLNDPRVYIGQCPDSGCFSLFNSEPDQCSTSHTHKPFCQCPDSGCFSLFNSEPDQCSTSNLCRPEQFCCHDGCKNVCLWKPPYAAILAKVEAQRRYQQQVLYQAEQKKKQEEAYREEQRRRAEMEQARRAARARAEAEAVLAAQKAKAEYQAKMQAKADAQAQAVSRLQQKMAQQQAASLLQQQQQQQQQQQPTSWTGQAQKSGGGDISLGGFFDALKKDKLAGTLTNQINSPANSINPYTAAGGAVNSLDKGGYSAAYDSSAGKQTGGSSSAISRALAELIMPANIQINQYSSPAMKVAPPTGNIAPPTRSNQAWSRAPSSQPVRLYSYQAAPQTSGMNNQYNQQPQQQQLQQQLLQQQQQQRHHQQPVEPLLMYHFMQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HL90</accession>
    <name>A0A3S1HL90_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_010436</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000320">
        <property type="protein sequence ID" value="RUS81799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HL90"/>
    <dbReference type="STRING" id="188477.A0A3S1HL90"/>
    <dbReference type="OrthoDB" id="10034757at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042327">
        <property type="term" value="P:positive regulation of phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18318">
        <property type="entry name" value="BTB_POZ_KCTD20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039886">
        <property type="entry name" value="BTBD10/KCTD20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039885">
        <property type="entry name" value="BTBD10/KCTD20_BTB/POZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21637:SF0">
        <property type="entry name" value="AT10158P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21637">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16017">
        <property type="entry name" value="BTB_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="135"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="429"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="437"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS81799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="474" mass="53745" checksum="C0293512E65D81D6" modified="2019-04-10" version="1">MAHRRNHPPRDRYHREYDFHSSDSDFSDADDHKKACIKKSSSIGPPRSKPCLVNRTRSTSLDSSNEDWPVEATCSSIAMYNLPSQSRPRDLEIHRHHSDTAAGGFDAGIAMPPPTYTMQASPKLGCGSGMRPSAERLTLVVDESRFVVDPELFRQRPETMLGRMFTSSLEHNFTRPNERGEYEVADGISATVFRAILDYYKSGVVRCPPSVPVHELREACDYLLVPFDASTVRCQNLRGFLHELSNEGARKQFLEYLEDLLLPQMVICAQRGDRECHIVVLTDDDLIDWDEDYPPQMGEEYSQIVNSTNLYRFFRYIENRDVAKQVLKERGLKKIRLGIEGYPTYKEKIKKRPGGRAEVIYNYVQRPFIRMSWEKEENKSRHVDFQCVKSKSITNLAQAADETPMMASGGSGLSNHGAGNQQIAMQVDGRDHHPHHQQGSIVQQAQDGSINVIPPQPSPSEPYPDVQLPPEALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HY78</accession>
    <name>A0A3S1HY78_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_003798</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000082">
        <property type="protein sequence ID" value="RUS88461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S1HY78"/>
    <dbReference type="OrthoDB" id="306254at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034453">
        <property type="term" value="P:microtubule anchoring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028750">
        <property type="entry name" value="CEP350/CC187"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13958:SF3">
        <property type="entry name" value="CAP-GLY DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13958">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN 350"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <end position="770"/>
        </location>
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            <begin position="1"/>
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        </location>
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            <end position="424"/>
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            <end position="855"/>
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            <end position="968"/>
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            <end position="1071"/>
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    </feature>
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            <end position="1123"/>
        </location>
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            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
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            <begin position="24"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
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            <end position="214"/>
        </location>
    </feature>
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            <end position="258"/>
        </location>
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            <end position="332"/>
        </location>
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            <begin position="541"/>
            <end position="562"/>
        </location>
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            <begin position="563"/>
            <end position="577"/>
        </location>
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            <begin position="897"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="931"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        </location>
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            <end position="1032"/>
        </location>
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        <location>
            <begin position="1094"/>
            <end position="1112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RUS88461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1331" mass="143899" checksum="4858B4EA20D3BFE6" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1I3K2</accession>
    <name>A0A3S1I3K2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_000691</name>
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        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    <dbReference type="OrthoDB" id="10051649at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS91576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="583" mass="65240" checksum="14A0F06C22D78CF7" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">EGW08_000381</name>
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        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
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            <taxon>Panpulmonata</taxon>
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            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="RUS91810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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            <end position="43"/>
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            <end position="130"/>
        </location>
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            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
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            <end position="1043"/>
        </location>
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            <end position="1254"/>
        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="609"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="828"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1110"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1344"/>
            <end position="1355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS91810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1661" mass="185844" checksum="05CC8C45C2E05D28" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SK57</accession>
    <name>A0A433SK57_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_022735</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oligoribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001661">
        <property type="protein sequence ID" value="RUS69506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SK57"/>
    <dbReference type="STRING" id="188477.A0A433SK57"/>
    <dbReference type="OrthoDB" id="270189at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06135">
        <property type="entry name" value="Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000003">
        <property type="entry name" value="Oligoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00045">
        <property type="entry name" value="Oligoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003765">
        <property type="entry name" value="PRK05359.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046:SF0">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="5">
        <location>
            <begin position="92"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS69506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="267" mass="30218" checksum="5597EB950AB04FF6" modified="2019-05-08" version="1">MLFSKCVQTFKPIYLNHNIKKLTANSRIRSSQNLRRATLSICAAKKSKFAAGVPVVFNRCGKENTHNCFQRINFSIPMSSSVKGADNMDSNRLVWIDLEMTGLDVEKERIIEIACLITEGDLTIVEKGPNLVIHQDNKFLDGMDEWCTLHHGQSGLTEAVRNSSISTEEAEAKVLSFVSQHVPPGKCPLAGNSVGTDKLFLERYMPKLAKHLHYRIVDVSTIKELCRRWYPEDFKKAPAKKLSHRAMDDIVESIEELKYYQAAVFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SKD6</accession>
    <name>A0A433SKD6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_022649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001628">
        <property type="protein sequence ID" value="RUS69589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SKD6"/>
    <dbReference type="STRING" id="188477.A0A433SKD6"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS69589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="272" mass="26129" checksum="9802E74A145062FF" modified="2019-05-08" version="1" fragment="single">TNAPTTPCPVHGGGVAVGGGGNFPSNININIQLQFGPNAGSNGGPNSGSGGQQQATCTCNQKQPQPTSQTPIVVQQGKGGNTTTVQASTNPTTATATNGSTTPQASTASSASPTATTPTAATSAANSTTPANATSTSAPSNMTTASTSSNITTTSVSMNATTPASSSNTTATPTAVNSTQAMNTTSSPSKTNATTASSKGKATSPSTANVTSSTSSNTTTAAPTTPSTASSTTPSTTPSTTTTTTSPTTTTPTTTTVVTSTSTPAMNTTPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SKK3</accession>
    <name>A0A433SKK3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">proline--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_022572</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="3"/>
    <dbReference type="EMBL" id="RQTK01001610">
        <property type="protein sequence ID" value="RUS69667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SKK3"/>
    <dbReference type="STRING" id="188477.A0A433SKK3"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00861">
        <property type="entry name" value="ProRS_anticodon_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00779">
        <property type="entry name" value="ProRS_core_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004500">
        <property type="entry name" value="Pro-tRNA-synth_IIa_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050062">
        <property type="entry name" value="Pro-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044140">
        <property type="entry name" value="ProRS_anticodon_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033730">
        <property type="entry name" value="ProRS_core_prok"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00409">
        <property type="entry name" value="proS_fam_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME PROTEIN L39/PROLYL-TRNA LIGASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753:SF2">
        <property type="entry name" value="PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="25"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS69667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="365" mass="41187" checksum="DCDFB3231BE2E234" modified="2019-05-08" version="1" fragment="single">SHQYMLKAGLIKKLASGIYIWLPMGLKVLHKIQEIVRKEMNSTGASELLLPSILPSELLKETHRWEKFGPELLKLKDRNDRDFCYGPTHEEPIVDMARDIIKSYKQLPLNLYQIQTKFRDEIRPRFGVMRSREFIMKDAYSFHENLDCLHHTYETMYQTYCNILDSIGLEYRPVKADTGSIGGDNSHEFQVLANAGEDVICYNVPNYTIADIRNIVSGDDSPDGNGTLELTNGIEVGHIFELEDVYSKPMNATIIGRDGKSMPLLMGCYGFGVSRVVAASIEQSHDDRGIVWPASIAPYDVAILPINYNKSEGVKELADSIYQDLKNNGLDVLLDDRGTRPGVMFADADLVGYTHHVIIGDRLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SKX8</accession>
    <name>A0A433SKX8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_022447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001575">
        <property type="protein sequence ID" value="RUS69790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SKX8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS69790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="499" mass="56471" checksum="55F2A58C1C459CA2" modified="2019-05-08" version="1">MLQWVLSPAIVIENTGPAHGRLTGVEHLVRSEVRPVRVEAGILVIEVNQPAGCHSPTHYFGLLLHLRQKPCLDGADVPSGSRKRKAMDAPTLLGVTAKTSWSPFLVISDVEKKVAKFTVFVIRKALSGTVGYQREYPCKFEDYEDMRSKRTCFKVINRTAAQQTWDMARADCKYSYYGDLYKISDAEEDSIIRGLKTLFLRYVTKSDLHAAESHVGIEGNEMARKFSVKTTRPEGGTRSSPTWTFSSYSRLSIESIAMDEQHDFHLHQNDNDNHGPDGQQPRRHQQQQQQLIALSSDDFSRLPGRPALSWRLPPGHRHPNIGFQMALNCSSLMDKHAQIRFEIAEGSYVTEVDNSSDDYGGIQFVITEDGRYVDVENRCFLRSAATMRVKVTALLFNVTISCCWHRLGWDPVCSDGLAVHPRYLPKRPVMNVLSHNLLKVGTYLIADCSACVGSDGQLTWLWIDQDKQKEWTSHFRSTDHNFFDPWDITLTEAEEKHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SLQ8</accession>
    <name>A0A433SLQ8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Coatomer subunit beta'</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EGW08_022189</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">EC2010</strain>
            <tissue evidence="17">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasmic vesicle</location>
            <location evidence="1 12">COPI-coated vesicle membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Golgi apparatus membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="12">The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the WD repeat COPB2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001504">
        <property type="protein sequence ID" value="RUS70050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SLQ8"/>
    <dbReference type="STRING" id="188477.A0A433SLQ8"/>
    <dbReference type="OrthoDB" id="2150324at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22947">
        <property type="entry name" value="Coatomer_WDAD_beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000001">
        <property type="entry name" value="Coatomer subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000008">
        <property type="entry name" value="Coatomer subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016453">
        <property type="entry name" value="COPB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF2">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005567">
        <property type="entry name" value="Coatomer_beta'_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="5 13" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="11"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="138"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="181"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="225"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="15">
        <location>
            <begin position="346"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="16">
        <location>
            <begin position="621"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="884"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="884"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="919"/>
            <end position="945"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RUS70050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="981" mass="109905" checksum="9EEE350589DF2FA4" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SM35</accession>
    <name>A0A433SM35_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cilia- and flagella-associated protein 58 central coiled coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_022013</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001459">
        <property type="protein sequence ID" value="RUS70225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SM35"/>
    <dbReference type="STRING" id="188477.A0A433SM35"/>
    <dbReference type="OrthoDB" id="10262929at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049270">
        <property type="entry name" value="CFAP58_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083">
        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083:SF34">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21771">
        <property type="entry name" value="CFAP58_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cilia- and flagella-associated protein 58 central coiled coil" evidence="4">
        <location>
            <begin position="442"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="939"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="158"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="528"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="703"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS70225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="993" mass="116454" checksum="057862622708A88E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SMU0</accession>
    <name>A0A433SMU0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_021763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001401">
        <property type="protein sequence ID" value="RUS70472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SMU0"/>
    <dbReference type="STRING" id="188477.A0A433SMU0"/>
    <dbReference type="OrthoDB" id="10018757at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001888">
        <property type="entry name" value="Transposase_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF1">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01359">
        <property type="entry name" value="Transposase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS70472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="36155" checksum="025B8D8700DEF093" modified="2019-05-08" version="1">MNKVRRCRALLSRRRIRPDRSISLRCRPTSVVTEKNVSTVEGLVKQDRRITVKQLASETRISVGSVEKILHDHLNLNKVSARWVPRLLTADQKKERADCCKHLLRLEANDDLFFQKIVTMDETWIYQFDPEPKNASMQWKRPSSPPPKKAKVTQSSGKVMLSCFWDCEGIIMTDYMEKGKTITGEYYSGLLKRLRSELVRRRRGKLRNGVLLLHDNAPAHRARQAVETADQCGYEILPHPPYSPDLAPSDFCLFPNLKKSIKGRRFEDIEDAISAVEEWFQAQNDTFYSQGLLKVKDRWQKCVTMQGDYVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SPP8</accession>
    <name>A0A433SPP8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_021049</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001258">
        <property type="protein sequence ID" value="RUS71197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SPP8"/>
    <dbReference type="STRING" id="188477.A0A433SPP8"/>
    <dbReference type="OrthoDB" id="10060792at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF26">
        <property type="entry name" value="RE23625P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00299">
        <property type="entry name" value="ACRYSTALLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="57"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS71197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="166" mass="19356" checksum="96111DDDB6CF6CAD" modified="2019-05-08" version="1">MERLVPLQRESWSFFDRQRQVFGDIFKDQDEEWKAFDRELERTRKEMFSLSSDFGSSSLIKPERPIVQDADGNKRLSLRFDCKEFKPEEITVKTIDNKLMVQAKHVEESPGRKVYREFTKQYVLPQKIDPLTLNSTLASDGVLSIEAPAPAAIEAPRERILPIKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SQJ4</accession>
    <name>A0A433SQJ4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_020746</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001204">
        <property type="protein sequence ID" value="RUS71495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SQJ4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="504"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS71495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="543" mass="59748" checksum="9A5795A90524CBAA" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SRX1</accession>
    <name>A0A433SRX1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_020270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001134">
        <property type="protein sequence ID" value="RUS71977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SRX1"/>
    <dbReference type="OrthoDB" id="10013157at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS71977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="113" mass="12699" checksum="4B6181E3F3D506E2" modified="2019-05-08" version="1" fragment="single">MRAHPEKYKEYNDMMACQPPRESDPFPQTAPLLPLRPKSCCPRISSGPELERKPSIPDAFKPREPPFHTSPMVGNQRVYGADTIRRLIHTPSAKYLGLKPPQPPNKDKAAPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SVA7</accession>
    <name>A0A433SVA7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Thiolase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_019048</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000967">
        <property type="protein sequence ID" value="RUS73186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SVA7"/>
    <dbReference type="STRING" id="188477.A0A433SVA7"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF107">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE, CYTOSOLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="5">
        <location>
            <begin position="4"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="6">
        <location>
            <begin position="146"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS73186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="28383" checksum="3D02C622265066FC" modified="2019-05-08" version="1" fragment="single">AVRNIRFGTRLGEGLKLEDSLWDSLTDSYCKFPMGMTAENLAEKYGLTREDCDRHAVQTQERWQIANKNGVFKDEITPITVKGKKGPESFEVDEHPRAATMEAMAKLPPVFKKNGTINAGNASGIVDGGCALVLASEAAVQKHGLEPLAKVVSYGISGCEPSIMGIGPVPASRAALAAIGKEVKDMDVVEVNEAFAPQFLAVSKELGLDNDKTNVNGGAIAIGHPLGASGARITTNLTHDIRRRGLKYALGSACIGGGQGITVIIERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SY28</accession>
    <name>A0A433SY28_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_018177</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000870">
        <property type="protein sequence ID" value="RUS74070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SY28"/>
    <dbReference type="STRING" id="188477.A0A433SY28"/>
    <dbReference type="OrthoDB" id="6149317at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF703">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="1"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS74070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="321" mass="35365" checksum="7612689032BE86B7" modified="2019-05-08" version="1" fragment="single">RIFISICLHVTMLGQSVVYLLMSSQNMEELLSPIRLDISTCGWTLIIAACLCPLCWFGTPKDFWPIALGAFASIGVACILLLIAMGQDARELSPSYHSPFRWTTFLMSFGTIFFAFGAHPSFPTFQSDMKQPKKFDRVLIFAFSILASLYLLVGVEGFLVYGSKVQPTVVMSLVPGPMPCAVQICVTIHLLCALVIVLNPVCQEGEELLNIPLYFCYQRVLFRTCVVCLVLFISLSVPQFDAIMSFVGGSSIVILTFVIPPICYLKLCSMKGPWEPIEVPLHQKLACVETIVVGGALGVAITLTALEALTYSQFSKPCYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SYK5</accession>
    <name>A0A433SYK5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nuclear protein localization protein 4 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_017839</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Protein degradation; proteasomal ubiquitin-dependent pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NPL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000834">
        <property type="protein sequence ID" value="RUS74404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SYK5"/>
    <dbReference type="STRING" id="188477.A0A433SYK5"/>
    <dbReference type="OrthoDB" id="10251089at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08061">
        <property type="entry name" value="MPN_NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000012">
        <property type="entry name" value="nuclear protein localization protein 4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016563">
        <property type="entry name" value="Npl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007717">
        <property type="entry name" value="NPL4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024682">
        <property type="entry name" value="Npl4_Ub-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007716">
        <property type="entry name" value="NPL4_Zn-bd_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710:SF0">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05021">
        <property type="entry name" value="NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11543">
        <property type="entry name" value="UN_NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05020">
        <property type="entry name" value="zf-NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010052">
        <property type="entry name" value="Polyub_prc_Npl4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MPN" evidence="9">
        <location>
            <begin position="232"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="8">
        <location>
            <begin position="589"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00074519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS74404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="619" mass="69893" checksum="234E9BA0D152402E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SZD9</accession>
    <name>A0A433SZD9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Endonuclease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_017577</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000810">
        <property type="protein sequence ID" value="RUS74671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A433SZD9"/>
    <dbReference type="OrthoDB" id="6139267at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000004">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF7">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="8">
        <location>
            <begin position="618"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="9">
        <location>
            <begin position="1215"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1444"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1444"/>
            <end position="1459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS74671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1499" mass="167133" checksum="50E485091DEC3A24" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T3Y3</accession>
    <name>A0A433T3Y3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_015984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000678">
        <property type="protein sequence ID" value="RUS76241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T3Y3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS76241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="341" mass="36931" checksum="3E39E2017947B244" modified="2019-05-08" version="1">MGALRGRGIWGHTSAGKRLSEETSSGATDRQSGSARTSILARDVTLTLARTWKRPEVIWYLRADLSFRSGHARGMLGPPGTHCVIERQLSCVPKNRAVKQDKHGVGFNKSKTCIRRPRGCLSGRPTVCTVYIPPYPDAIAAVVSRPQVIYSHHFDTLEAVMMSALPATNHGDPLSAGSRAGEIYTLSQIKSDSSLGLRLGMSLELADVESFPGVAVCPSRLVDSSGLDPEYLLQTVGQGGGCAEGLPVSYTRHDLTPGPSGRDTWQREIDRHTDIHTERQKALRNRWIIGYGGSELYDGAVTIPPAQVAKPTIIGSSRAGKSFQHVLWTLTPRSLFVLVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T6V1</accession>
    <name>A0A433T6V1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">c-SKI SMAD4-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_014908</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SKI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000589">
        <property type="protein sequence ID" value="RUS77332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T6V1"/>
    <dbReference type="STRING" id="188477.A0A433T6V1"/>
    <dbReference type="OrthoDB" id="3938623at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046332">
        <property type="term" value="F:SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030514">
        <property type="term" value="P:negative regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21079">
        <property type="entry name" value="DHD_Ski_Sno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.20:FF:000002">
        <property type="entry name" value="SKI-like oncogene a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.390.10">
        <property type="entry name" value="SAND domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.20">
        <property type="entry name" value="Ski"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014890">
        <property type="entry name" value="c-SKI_SMAD4-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010919">
        <property type="entry name" value="SAND-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003380">
        <property type="entry name" value="SKI/SNO/DAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037000">
        <property type="entry name" value="Ski_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023216">
        <property type="entry name" value="Tscrpt_reg_SKI_SnoN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10005">
        <property type="entry name" value="SKI ONCOGENE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10005:SF25">
        <property type="entry name" value="SNO ONCOGENE, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08782">
        <property type="entry name" value="c-SKI_SMAD_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02437">
        <property type="entry name" value="Ski_Sno_DHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01046">
        <property type="entry name" value="c-SKI_SMAD_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63763">
        <property type="entry name" value="SAND domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="c-SKI SMAD4-binding" evidence="3">
        <location>
            <begin position="208"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="300"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="462"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="753"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="819"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="300"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="340"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="377"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="462"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="479"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="530"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="595"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="753"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="763"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="831"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS77332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="859" mass="94273" checksum="C1A3268721F5B3F0" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T6Z3</accession>
    <name>A0A433T6Z3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_014852</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000585">
        <property type="protein sequence ID" value="RUS77372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T6Z3"/>
    <dbReference type="STRING" id="188477.A0A433T6Z3"/>
    <dbReference type="OrthoDB" id="6056726at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="34"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="110"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS77372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="180" mass="20579" checksum="F01C2E3A043AD0E0" modified="2019-05-08" version="1">MWGKKAITRQGAKRIHAKKSAVQPDEHPLTITEDQKVQLRRAFAMFEKTGKGRIPSRDLVALLRCLGWNPSEQDLEEARHELDLAAKGYISFSDVETYIARRGGIYNGANAEEDILMAFQVLDKHGTGRITVRDFRHFLTTMGERMSTEEAEELISCSRRDGKDYIEYRDLVHAVQQLNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T866</accession>
    <name>A0A433T866_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coiled-coil domain-containing protein 57</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_014506</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000557">
        <property type="protein sequence ID" value="RUS77718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T866"/>
    <dbReference type="STRING" id="188477.A0A433T866"/>
    <dbReference type="OrthoDB" id="568502at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007099">
        <property type="term" value="P:centriole replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045931">
        <property type="term" value="P:positive regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042481">
        <property type="entry name" value="CCDC57"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46725">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46725:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="541"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="780"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="913"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1016"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="681"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="807"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="784"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="913"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="949"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1017"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1084"/>
            <end position="1093"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS77718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1093" mass="126769" checksum="63517B420767B743" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T956</accession>
    <name>A0A433T956_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_014245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000539">
        <property type="protein sequence ID" value="RUS77984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T956"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS77984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="118" mass="12968" checksum="8C2B909071A7292A" modified="2019-05-08" version="1" fragment="single">VLYGVMPTSTHISSHVLYGVMPTSTHKSSHVLYGVMPTSTHKSAHVLYGVMPTSTHKSSRVLYGVMPTSKHKSSRVLYGVMPTSTHKSSHVLYGVMPTSKHKSSRVLYGVMPTFKHKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TA93</accession>
    <name>A0A433TA93_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Pyruvate kinase</fullName>
            <ecNumber evidence="4 13">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EGW08_013719</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">EC2010</strain>
            <tissue evidence="16">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the pyruvate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="4 13"/>
    <dbReference type="EMBL" id="RQTK01000505">
        <property type="protein sequence ID" value="RUS78507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TA93"/>
    <dbReference type="STRING" id="188477.A0A433TA93"/>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="14">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="15">
        <location>
            <begin position="81"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RUS78507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="226" mass="24611" checksum="DA8680D6591991B4" modified="2019-05-08" version="1">MLESMVTNARPTRAEASDVANAILDGTDCVMLSRETALGKEPARVVQTLAQISQEAENALYYDATFRDLRFATPIPTNVTHATSIAAVEAAIRGSASAIIVVTNSGRSARLIARYRPHCIIIAITKSQHTARHLNLYRGVFSVIHTGSSNTEWYCDVDQRIHYALGVAMDRGYVRPNDKAVLVTGYQAGPGSTNCVRSIVVPRREEKASYLAIVSHTNNDDDSCSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TBS5</accession>
    <name>A0A433TBS5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tyrosine-protein phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_013204</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000475">
        <property type="protein sequence ID" value="RUS79047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TBS5"/>
    <dbReference type="STRING" id="188477.A0A433TBS5"/>
    <dbReference type="OrthoDB" id="6153587at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF559">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="129"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS79047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="34417" checksum="7C0532C1CECE4EBB" modified="2019-05-08" version="1">MGKYINAVLVPTLSKDRQDILTQLPLPSTVTDFWRLVTQYHVGLVVAFDTDSRHTDETVGEFLPASEAEPMRGALFEIQARWEGQGQLWTEVKATVFKKRKSLLGSTAEQHHVTCLLCKDSRPSTRTMLEYLRKIKSCRPPEQSRTLYMCRNGADLCGLVCVQSILLDRLDTDQCVSVPLVVGAIRAIRPQVIPTLDQYRSLYSVLKLVQDSSSVYGNVSSPGSPAGGTSKQGGPGTVEDSALPSVIQSIQSDGGGDTPGDSSPSSPRPPVHESGGVVIVSVGNNVQGGRDEDGDVDVDKGASPIGAMQGRSDGIEYANM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TBW8</accession>
    <name>A0A433TBW8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Torsin-1A-interacting protein 1/2 AAA+ activator domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_013156</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endomembrane system</location>
            <topology evidence="9">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TOR1AIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000471">
        <property type="protein sequence ID" value="RUS79103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TBW8"/>
    <dbReference type="STRING" id="188477.A0A433TBW8"/>
    <dbReference type="OrthoDB" id="6258998at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038599">
        <property type="entry name" value="LAP1C-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008662">
        <property type="entry name" value="TOIP1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046753">
        <property type="entry name" value="TOIP1/2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18843:SF7">
        <property type="entry name" value="LAMINA-ASSOCIATED POLYPEPTIDE 1B ISOFORM 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18843">
        <property type="entry name" value="TORSIN-1A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05609">
        <property type="entry name" value="LAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Torsin-1A-interacting protein 1/2 AAA+ activator" evidence="12">
        <location>
            <begin position="207"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS79103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="423" mass="46664" checksum="665E7CA26136B7B4" modified="2019-05-08" version="1">MPGRSPISPKSRSTRSPSANNRTTDLSESDEDVKYISAANFSTRSTASSHAGSQDDSLLAEDDDDFQEKSYSGSPHQLETKVRSRVGTRTRGSSSTSPGLQTYGGQRLYPDLSDDSFNSIGDGPSPKDGNKNKHKKVYPSLPKVVQDPESRKIKNMPSLQEKLKDDSSRSSNIFFFPVLVLIALILFIYFGGLPRTVGDTADANLNIFEKYIKGIDYLQKEFPQQSPRLWRTLKSSAKHVLNATDPVYPVVVLMAAPIQNFELTKCLAERVASFYQASMTGDSVNVKTCDIRGYKNLQDARQKKALDDEMTQTFSENGGKSFVIVNLQDLAPEAALILHGFCDNDNAPYKDVMILMTLHFSPKDLQPSGNGKFGEEDVEVYLRNLWGRGLVADKVGALLSRVGNNIVIIGEEASESVKKVCKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TED4</accession>
    <name>A0A433TED4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">serine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_012314</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="2"/>
    <dbReference type="EMBL" id="RQTK01000420">
        <property type="protein sequence ID" value="RUS79926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TED4"/>
    <dbReference type="STRING" id="188477.A0A433TED4"/>
    <dbReference type="OrthoDB" id="10264585at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000078">
        <property type="entry name" value="Seryl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="8">
        <location>
            <begin position="208"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS79926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="482" mass="55308" checksum="183AEC58CAA70A0B" modified="2019-05-08" version="1">MLKLNTVLQADLCIRALIQYRILHSSILQKLSISRFNHLQRELSTSSHRYFHTQKPTKSKHRYLQPKEWDEPFTLPHLGLDWHFLLNKENRDLIAENIAHRKGVGDIDKVLDLADKLKEEQDAAQKEIIKENLISEALDIPNFSHPNSPIGGDTEAQEIKVIGSKREFDFKPRMVREIAGKGLRMYRDENLTFTTGSKTYFLEDGLARLEQALVSYTVEKLMKKGFELVSVPDLLQCDVVDSCGFKTASDRSQVYRIHPKCYPDVCLSGTAEMALAGYFMDEVIPHEELPKKVMAVSRCYRAEAAEKAIERGLYRVHHFTKVEMFGVTASENGTESDYLLQDILSIETELFEDLGLHFRVLEMPTQELGAPAHRKYDIEAWMHGKNIWGEISSCSNCTDFQSRRLNIRYTDPSGQIRYAHTVNGTGCAVPRMIIAILEQNQQQGRKLTLPEVLWPYMQGETYLSGEGKTKSWYTFVKTLRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TFG0</accession>
    <name>A0A433TFG0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_011965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000401">
        <property type="protein sequence ID" value="RUS80281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TFG0"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS80281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="161" mass="18090" checksum="5C4F16F51584ED89" modified="2019-05-08" version="1" fragment="single">YLLIFDPAFADNDILYSCAASEFLLVNGVMFVDLLTLVLRKMIQGILVHHPSSFFSNSHLSLRFLKLSKGSQELLTDIILSEKLNASFINGSSTVYVTILFFKPRIFDPVFYLWMHKHNKDISLVDGPCSVKLLVPQLEVDVGVPGLLLGLPFHPAFKHLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TFG9</accession>
    <name>A0A433TFG9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_011923</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000399">
        <property type="protein sequence ID" value="RUS80322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TFG9"/>
    <dbReference type="STRING" id="188477.A0A433TFG9"/>
    <dbReference type="OrthoDB" id="5959154at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14981">
        <property type="entry name" value="7tmA_Prostanoid_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008365">
        <property type="entry name" value="Prostanoid_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11866">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR FAMILY 1 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11866:SF16">
        <property type="entry name" value="PROSTAGLANDIN E2 RECEPTOR EP4 SUBTYPE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01788">
        <property type="entry name" value="PROSTANOIDR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="16"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS80322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="368" mass="40824" checksum="245C28897BE4A5E5" modified="2019-05-08" version="1" fragment="single">RSVVVPSAMFAAGAIGNTLALVLMATSPVEQRRTHFYKLMFGLALTDLMGTCTTSPVAINIYATGAKLETHMPLCHYFSFMLMFAAFATMSVVCAMAVERYICLCHPYFYQCKLPKSYARYALIISWTLSGIIAALPLVGLGRSVAQFPRTWCFFDATSRRPQDRAFSIIFASITLLAIGVTLCCNVAAIYSVLALRRRQKALKTSQGPAGSGGRSLAHRFAELHMLVILVGVTIIFTSCFAPLMVRYKWVYYYMFCDPQQHRDSCDSVFGYLDSPAFEKSPTPSDSDMSFWAFCFHCLCDPPVDRSSNALARSRVLGSRASINVRRSPARNLTRNASTESILNPSRDRNCVNTQPLASDQILLTKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433THE2</accession>
    <name>A0A433THE2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Acyl-coenzyme A thioesterase 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Hotdog-fold thioesterase superfamily member 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Palmitoyl-CoA hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Thioesterase superfamily member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">EGW08_011273</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">EC2010</strain>
            <tissue evidence="25">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a fatty acyl-CoA + H2O = a fatty acid + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16781"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:77636"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:16782"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>decanoyl-CoA + H2O = decanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40059"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27689"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:61430"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:40060"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>dodecanoyl-CoA + H2O = dodecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18262"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57375"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:30136"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>hexanoyl-CoA + H2O = hexanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40115"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17120"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:40116"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>octanoyl-CoA + H2O = octanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25646"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:30144"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="19">Homotetramer. Interacts with PCTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000363">
        <property type="protein sequence ID" value="RUS80953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433THE2"/>
    <dbReference type="STRING" id="188477.A0A433THE2"/>
    <dbReference type="OrthoDB" id="46529at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000021">
        <property type="entry name" value="Acyl-coenzyme A thioesterase 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="24">
        <location>
            <begin position="58"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00050199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00052976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00058205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00064709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00067273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00075657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00081533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00083956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="RUS80953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="160" mass="16417" checksum="54ED7C6BFD7F1D20" modified="2019-05-08" version="1">MTAGTGKLTFEAVKAMVAHRASLPGFESLFKQMTVVSAGGGKCLCELRVQPKMLNVSGKLHGGVTASLVDAVSTYALTTTGQGRSGSSIELSVSYLRPVNLGDDIIIAAQTLRCGKTVAVCTVDVTSKSSGELVAHGKHSKFVGDAKTGNSVLDEKGSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TIJ4</accession>
    <name>A0A433TIJ4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein FAM136A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_010846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM136 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000339">
        <property type="protein sequence ID" value="RUS81408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TIJ4"/>
    <dbReference type="STRING" id="188477.A0A433TIJ4"/>
    <dbReference type="OrthoDB" id="9975421at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008560">
        <property type="entry name" value="DUF842_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21096">
        <property type="entry name" value="PROTEIN FAM136A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21096:SF0">
        <property type="entry name" value="PROTEIN FAM136A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05811">
        <property type="entry name" value="DUF842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS81408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="15674" checksum="3E767EC7BEEFF4A4" modified="2019-05-08" version="1">MDGAQARVQEAVSKMVNSLDTGCLRKMQVAMYQCSAKCCENTKSTLEDVQSCIDTCSKDVNKAQAYLQNEIEMFQNRLQRCAMSCQDKLRDQMPAKPTDKDVEKGRSGLEKCVIECADSHVGHIPGLTKKMLEVLQSKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TK47</accession>
    <name>A0A433TK47_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Receptor L-domain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_010268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000311">
        <property type="protein sequence ID" value="RUS81970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TK47"/>
    <dbReference type="STRING" id="188477.A0A433TK47"/>
    <dbReference type="OrthoDB" id="5809444at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.20.20">
        <property type="entry name" value="Receptor L-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000494">
        <property type="entry name" value="Rcpt_L-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036941">
        <property type="entry name" value="Rcpt_L-dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01030">
        <property type="entry name" value="Recep_L_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Receptor L-domain" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS81970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="100" mass="11114" checksum="FD505BC0F7DB71DE" modified="2019-05-08" version="1" fragment="single">SFPDLKEITGYLVISGAFGLRTLRHLLPGLTVIRGEQLFLDTFALVVHDNPHLQELGLVSLNTIMHGAARLSQNAFLCYVETVDWPMLTVGVKASENFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TK56</accession>
    <name>A0A433TK56_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_010293</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000313">
        <property type="protein sequence ID" value="RUS81948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TK56"/>
    <dbReference type="STRING" id="188477.A0A433TK56"/>
    <dbReference type="OrthoDB" id="9000293at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000029">
        <property type="entry name" value="Acetylcholinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019544716" description="Carboxylesterase type B domain-containing protein" evidence="6">
        <location>
            <begin position="26"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="27"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600997-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS81948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="550" mass="60746" checksum="E9CA092307BB4BA0" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TLZ5</accession>
    <name>A0A433TLZ5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_009698</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000282">
        <property type="protein sequence ID" value="RUS82526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TLZ5"/>
    <dbReference type="STRING" id="188477.A0A433TLZ5"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS82526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="124" mass="12420" checksum="9280B0120C9D3D67" modified="2019-05-08" version="1" fragment="single">GGVCQGRGVYAREGWCMPGKGGVCQGRGVYAREGGCMPGKGGVCQGRGVYAREGGCMPGKGGVCQGRGVYAREGGCMPGKGGVCQGRGVYAREGGCMPGKGGVCQGRVVYAREGWCMPGKGGVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TUN7</accession>
    <name>A0A433TUN7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_006937</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000175">
        <property type="protein sequence ID" value="RUS85290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TUN7"/>
    <dbReference type="STRING" id="188477.A0A433TUN7"/>
    <dbReference type="OrthoDB" id="418911at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044666">
        <property type="term" value="C:MLL3/4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051630">
        <property type="entry name" value="Corepressor-Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017:SF1">
        <property type="entry name" value="LD02225P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS85290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="211" mass="23670" checksum="4F7D85AAE5F71AD5" modified="2019-05-08" version="1">MRKRGYTDVPTETAESPAGQRHGIRIIQSECHYVCTVPAARHVGTRHGTLLSRQPFHSGRVNIHSVIRAIQVFQQLLYADPGFKRASEVHLRLALMFKVLKQYDTSLKHFKLTLADSNPCISPQPEIRLHIAHLYEVQGKYKQAKEAYETFIQTDQLTPALKAAGLRQLGGKLTQDFPGLLQSWLSHAFNSQMLALSGRVVVHVALGIKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TVS4</accession>
    <name>A0A433TVS4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_006630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000164">
        <property type="protein sequence ID" value="RUS85618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TVS4"/>
    <dbReference type="STRING" id="188477.A0A433TVS4"/>
    <dbReference type="OrthoDB" id="10266825at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS85618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="145" mass="15467" checksum="FF3BED36F50D9130" modified="2019-05-08" version="1" fragment="single">LWHLEALPVHDGWAGLVIFLLGDPHLLEGGQGSQDGASDPDRVFTLRGSDDLDLHGGWCKGCNFFLHTVSNAGEHSSATRQNGVGIKVLTDVNVAFHDGVVGGLVDASRFHTQEGWLEQSFWAPESLVANGDDLTVGKLVALLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TW71</accession>
    <name>A0A433TW71_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_006421</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000159">
        <property type="protein sequence ID" value="RUS85792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TW71"/>
    <dbReference type="OrthoDB" id="6051850at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="184"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS85792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="663" mass="72560" checksum="C37ED86098CC42B9" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TWA3</accession>
    <name>A0A433TWA3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_006344</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AFG1 ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000157">
        <property type="protein sequence ID" value="RUS85860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TWA3"/>
    <dbReference type="STRING" id="188477.A0A433TWA3"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003045">
        <property type="entry name" value="GD10885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040713">
        <property type="entry name" value="ZapE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169:SF6">
        <property type="entry name" value="AFG1-LIKE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="496"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="507"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS85860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="58547" checksum="CCF80359F25A73EB" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TWK0</accession>
    <name>A0A433TWK0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ras-related protein Rab-14</fullName>
            <ecNumber evidence="7">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">EGW08_006308</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">EC2010</strain>
            <tissue evidence="24">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Early endosome membrane</location>
            <topology evidence="4">Lipid-anchor</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
            <location evidence="3">trans-Golgi network membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Recycling endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="7"/>
    <dbReference type="EMBL" id="RQTK01000156">
        <property type="protein sequence ID" value="RUS85905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TWK0"/>
    <dbReference type="STRING" id="188477.A0A433TWK0"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045335">
        <property type="term" value="C:phagocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090382">
        <property type="term" value="P:phagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04122">
        <property type="entry name" value="Rab14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000344">
        <property type="entry name" value="Ras-related protein Rab-14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030702">
        <property type="entry name" value="Rab14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0007">Acetylation</keyword>
    <keyword evidence="21" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="12" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="19" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0488">Methylation</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00014884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="RUS85905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="215" mass="24015" checksum="7C336E1E338B7D04" modified="2019-05-08" version="1">MAAGPYNYSYIFKYIIIGDMGVGKSCLLHQFTEKKFMADCPHTIGVEFGTRIIEVASQKIKLQIWDTAGQERFRAVTRSYYRGAAGALMVYDITRRSTYNHLSSWLTDARNLTNPNTVIFLIGNKCDLDAQRDVTYEEAKQFAEENGLMFLECSAKTGENVEDAFLDTAKKIYQNIQDGSLDLNAAESGVQHKPATPRITMNTGVQPPNKEGCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TWU6</accession>
    <name>A0A433TWU6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_006277</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000155">
        <property type="protein sequence ID" value="RUS85948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TWU6"/>
    <dbReference type="OrthoDB" id="6162636at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37492">
        <property type="entry name" value="SI:CH211-171H4.7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37492:SF4">
        <property type="entry name" value="TSC22 DOMAIN FAMILY PROTEIN 3 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="855"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="589"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="786"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS85948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="873" mass="90906" checksum="A8A1E9A223FF2092" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TZG6</accession>
    <name>A0A433TZG6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_005287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000123">
        <property type="protein sequence ID" value="RUS86962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TZG6"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS86962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="262" mass="28690" checksum="7441B87798EB38CE" modified="2019-05-08" version="1">MRRLGGRMKRDEKIQIWKTEQVQVPDSYSLACTVQFGCIVAATSKIGGARSRFQSRGNMKNYIHIIIPGWKKRSFILCESLLGLKKSSIQRLEPRSEVHVPTLVAGIALTRTVQEERCLHHGPPAQSSVLAPPSWTSCLPRVRCSGLHHGPPAQSSVLGPPSWTSCPEFGARSSIMDLLPRVRCSDLHHGPPAQSSVLGPPSWTSCPEADARASIMDLLPRVRCSCLHHGPPAQRLVLAPPPWTSCPEADARVSIMDLLPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U0C7</accession>
    <name>A0A433U0C7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Transmembrane protein 93</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_005004</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000116">
        <property type="protein sequence ID" value="RUS87252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U0C7"/>
    <dbReference type="STRING" id="188477.A0A433U0C7"/>
    <dbReference type="OrthoDB" id="16510at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008504">
        <property type="entry name" value="Emc6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029008">
        <property type="entry name" value="EMC6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07019">
        <property type="entry name" value="EMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS87252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="115" mass="12835" checksum="7C97081DC5030612" modified="2019-05-08" version="1">MATIAVRTRKSRKSEGIAYSELSLRQNASILEYCRTSMSALSGATAGILGLTGLWGFIFYFITALMLSVALLMKAGTRWNAYFMTRSVLFSNGLLGGLFTYVLFWTFLYGMVHVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U255</accession>
    <name>A0A433U255_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_004318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000097">
        <property type="protein sequence ID" value="RUS87902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U255"/>
    <dbReference type="STRING" id="188477.A0A433U255"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019213">
        <property type="term" value="F:deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020043">
        <property type="entry name" value="Deacetylase_Atu3266-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42717">
        <property type="entry name" value="DIHYDROOROTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42717:SF1">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE AND RELATED AMIDOHYDROLASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS87902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="29830" checksum="8337434867FE45E0" modified="2019-05-08" version="1">MASFVLKNGRIIDPSTGLDGIGDIYVTADGKIAAIIPEVSSRGAQTPEADGHQLSEFSRVDVTGCLVTPGLIDCHVHAYEHATPLGINLDKTCLARGVTAVLDAGSAGCSTVPGLLKYVGERSQTRLYCLLHIARHGLADAGCVTSTAGGECDSLNVVDVDACVKTIKANRNNIVGVKVRLASMVCDNGKNEAEVFRRALQASKECSVPLMVHHSLSSLPLGGGSGPGCPADLRPGDIYTHCFHGQPERIVDWETGVVSPHVWDAKRRGVLFDVGHGQGNWSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U6D6</accession>
    <name>A0A433U6D6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_002829</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000057">
        <property type="protein sequence ID" value="RUS89392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U6D6"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019529749" evidence="2">
        <location>
            <begin position="18"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS89392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="296" mass="32150" checksum="E184A3BB0094C518" modified="2019-05-08" version="1" fragment="single">VTVAAVVPILPLTVVVSEIVTFALASAAASPPMVQVIASPPPPATPYRYHLLCSSSTKRHLGRRSHCQDDIVTRRESGITGGLDQTTASTAVPSSASPLAQHTPASTSAASSLSLTPSPHGDGAPGRWHDADPTLWTQHLTGSPLDPTSPPGWSSGKSDVSTSSSCGDETSPMSQRLPSLAFPEGKKLMKLRQQIQQHFLHTHTHNHHHHHHHPYQQQQQQRQHPRRRRFDFSRLAESATTSDLEGCQSPDSSASISPPISYSSFQREGDISRDLDLVMEEPHPHHAHSHSDHAHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U6G2</accession>
    <name>A0A433U6G2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dynein light intermediate chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_002844</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
            <location evidence="1 11">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the dynein light intermediate chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000057">
        <property type="protein sequence ID" value="RUS89407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U6G2"/>
    <dbReference type="STRING" id="188477.A0A433U6G2"/>
    <dbReference type="OrthoDB" id="27603at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008467">
        <property type="entry name" value="Dynein1_light_intermed_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022780">
        <property type="entry name" value="Dynein_light_int_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688:SF0">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05783">
        <property type="entry name" value="DLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 11" id="KW-0243">Dynein</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="181"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS89407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="301" mass="33960" checksum="8840C36407ED7D70" modified="2019-05-08" version="1" fragment="single">MAPITEKENKMENLDEDNNPDDSENLWASILTEVQSSSGSASKLPTARTLLVLGDNECGKTTLIAKLQGVEEPKKGSGLEYYYLDVKDEYRDDQARLNVWVLDGDPHHTGLLKYALKQETFSDTMVLLVASMSQPWSLLDTLNRWAEVLSDHIDKLRIPVDKMQEYEQSLVRCYQAYTEPGDGPIATQGPPRGDINPLHPPASGSDEEESLPLGEKTLSNNLGIPIVVVVTKSDAISMLEKELDYKDEHLDFIQQHIRKFCLKYGAAMFYTSVKDERNCDLLYRYLVHRIYGFPFTSPALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U8C3</accession>
    <name>A0A433U8C3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_002184</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000041">
        <property type="protein sequence ID" value="RUS90071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U8C3"/>
    <dbReference type="STRING" id="188477.A0A433U8C3"/>
    <dbReference type="OrthoDB" id="6149986at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF300">
        <property type="entry name" value="PICKPOCKET PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 11" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="9 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="178"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="233"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS90071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="600" mass="66860" checksum="4C4319FCF60CD77B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U9X0</accession>
    <name>A0A433U9X0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-tyrosine-phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_001680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000029">
        <property type="protein sequence ID" value="RUS90592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U9X0"/>
    <dbReference type="STRING" id="188477.A0A433U9X0"/>
    <dbReference type="OrthoDB" id="165498at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052074">
        <property type="entry name" value="NonRcpt_TyrProt_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46900">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46900:SF2">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="137"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="529"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="714"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="889"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="1099"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="265"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="331"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="617"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="469"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="617"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS90592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1184" mass="130061" checksum="A1A975F99A7F6EA2" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UBJ7</accession>
    <name>A0A433UBJ7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">H15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_001128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000018">
        <property type="protein sequence ID" value="RUS91103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UBJ7"/>
    <dbReference type="OrthoDB" id="10598444at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS91103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="26357" checksum="DE04ACA9D326E6AC" modified="2019-05-08" version="1">MRCFGLRDYYFPHALSFYWLALNMARVEDDREQLDRESSSEMDSELEEAEASEAEETGDEKQELAKAEAGSSSRSDSKQEKPVTVREKDVLKALKSRPKGLSLNDIKKIVMKENAALEKLSVKSVKSKIMCALDKVVQKGRAVKQGPGLNFKLLQADDDDEELGLGSRRDRKRRRRSRSRGSRAGKKSRSNKRKSRSRSRSRSGKKRAPSKKRKARRSKSRGRGRRARGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UDT3</accession>
    <name>A0A433UDT3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_000198</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000003">
        <property type="protein sequence ID" value="RUS91985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UDT3"/>
    <dbReference type="STRING" id="188477.A0A433UDT3"/>
    <dbReference type="OrthoDB" id="10015593at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000322">
        <property type="entry name" value="GDNF-inducible zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001370">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24390:SF159">
        <property type="entry name" value="GROWTH FACTOR INDEPENDENT 1 TRANSCRIPTIONAL REPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24390">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="401"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="429"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="456"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="535"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="669"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="698"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="726"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="754"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="828"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="144"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="881"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="148"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS91985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="919" mass="104718" checksum="CEA48D43890D9F08" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z4K2</accession>
    <name>A0A3S0Z4K2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein FAM33A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EGW08_021678</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">EC2010</strain>
            <tissue evidence="17">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SKA2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001381">
        <property type="protein sequence ID" value="RUS70564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z4K2"/>
    <dbReference type="STRING" id="188477.A0A3S0Z4K2"/>
    <dbReference type="OrthoDB" id="193920at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000940">
        <property type="term" value="C:outer kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026762">
        <property type="entry name" value="Ska2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042091">
        <property type="entry name" value="Ska2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32017">
        <property type="entry name" value="SPINDLE AND KINETOCHORE-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32017:SF3">
        <property type="entry name" value="SPINDLE AND KINETOCHORE-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11362">
        <property type="entry name" value="DUF3161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16740">
        <property type="entry name" value="SKA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="12" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ska2 N-terminal" evidence="16">
        <location>
            <begin position="2"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="116"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="39"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RUS70564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="262" mass="28657" checksum="522C4331C9B33B83" modified="2019-04-10" version="1" fragment="single">KFNKADADLKHLTLRLERQLDIGKGNTDQENPVRLMKEIDGVKAEYTNLRQEMAGIQAAQKDAVDFLRSQLLSMSEMVQKLETQTGQRNPELEETSRVMLTELSQLMGVPIEALQAPSGSAASNTAQSEQEESEGATASITASESVTKATNSVSAEAAEQPAVEPSAAERRESSSEFVEVSAEEFASVSELIRGRSKLEDVNRTYSLLWDHFKVQDNTKDLTPKDMNTMGLRVSGATGQAKLKVLRALKLCKIDKAGNVNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z6K6</accession>
    <name>A0A3S0Z6K6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynein heavy chain linker domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_021774</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001403">
        <property type="protein sequence ID" value="RUS70466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z6K6"/>
    <dbReference type="STRING" id="188477.A0A3S0Z6K6"/>
    <dbReference type="OrthoDB" id="6143532at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF68">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS70466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="40812" checksum="5B303F2A22B5D0DC" modified="2019-04-10" version="1">MYHSAGVFVKEMQRLYTRLFLDSGMPPRDACDVSYYCSQLTKHDAQMKVLERLPDSQKLGMFLVDLSPFKDCAQRAHIAGQQSTHLLMNSDLSLKVVMFLEKLDFLHRTLESHPTTTDLLFRRLTVMDSLESRLDTILTVSGGQIAALYDVADRFSVPHKVAERQSFESSHYLVSSIKEVWIESLGERDQVVTEIQRLLGRDVAWVQAQVPKVLRPMVEQSLFLNGKSDPEKVKVALTETEEVVRSHVTKANFVREVQQYLKLPESQFKELFQVASRYVNTRNLWLLMADWDAKLYSWKHQSFESLDIQKINSYTFKYMEACDKLEQVLPKNTVVTVFGEKVDMMLRGRGVWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZC45</accession>
    <name>A0A3S0ZC45_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SMB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_017940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000845">
        <property type="protein sequence ID" value="RUS74303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZC45"/>
    <dbReference type="OrthoDB" id="6155123at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036024">
        <property type="entry name" value="Somatomedin_B-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001212">
        <property type="entry name" value="Somatomedin_B_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01033">
        <property type="entry name" value="Somatomedin_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00201">
        <property type="entry name" value="SO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90188">
        <property type="entry name" value="Somatomedin B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00524">
        <property type="entry name" value="SMB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50958">
        <property type="entry name" value="SMB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMB" evidence="2">
        <location>
            <begin position="95"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS74303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="702" mass="78621" checksum="E01C6645D79C5BC4" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZDD6</accession>
    <name>A0A3S0ZDD6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AN1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_015879</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000669">
        <property type="protein sequence ID" value="RUS76349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZDD6"/>
    <dbReference type="STRING" id="188477.A0A3S0ZDD6"/>
    <dbReference type="OrthoDB" id="431929at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057358">
        <property type="entry name" value="UBL_ZFAND1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677:SF37">
        <property type="entry name" value="AN1-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677">
        <property type="entry name" value="ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25327">
        <property type="entry name" value="UBL_ZFAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="5">
        <location>
            <begin position="4"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="AN1-type" evidence="5">
        <location>
            <begin position="56"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS76349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="265" mass="29258" checksum="FF04197230D2FEAB" modified="2019-04-10" version="1">MELPHIGRNCEAVNCNQLDFLPFVCNGCGKVFCLQHKSCDQHGCTAPGPSHQGYDGERSYSCSIPCCGKKELTPIQCQHCGQMFCLSHRTQEDHSCEKLSGRARELTKTAEHVEAILAQKEFKPKVAPTNPKAIQMAAKISLMKLKGKATGDVGLPQAERVYFNILLPLEAKKPPLPIFVSKVWRIGRLIDDVADKASITNRNNTNAAQKLAVFHGDTGLRLSPESTINDLLDDSSVMLLNGSTLILENVEDTIEVLDNLKLYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZDQ1</accession>
    <name>A0A3S0ZDQ1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_016957</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000755">
        <property type="protein sequence ID" value="RUS75291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZDQ1"/>
    <dbReference type="STRING" id="188477.A0A3S0ZDQ1"/>
    <dbReference type="OrthoDB" id="6250593at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903078">
        <property type="term" value="P:positive regulation of protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003009">
        <property type="term" value="P:skeletal muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059031">
        <property type="entry name" value="SH3_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039688">
        <property type="entry name" value="STAC1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15135">
        <property type="entry name" value="STAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15135:SF7">
        <property type="entry name" value="STAC-LIKE, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26085">
        <property type="entry name" value="SH3_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SH3" evidence="11">
        <location>
            <begin position="103"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS75291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="226" mass="25520" checksum="DB3612A603065A41" modified="2019-04-10" version="1">MAVPFPASHSPKTRRKRLSARMKSFSLDAPDPPKQLLGIDEMTKKKSSSFTNTCFGQPNIPVGVNANKKKFVFSLRSTSLEIEDSKRRSRSQSPQISPRSKKKETDIFVSLYHFRGKEKDDMDLRPGYRVTVTNSSDPDWWKGKCGSRSGYFPAKYLLKLAKYQRVYQVTHTMNLTEIDGHGGMRLHKDQIVLGVGDPPEEEATVIHVKAANNKEAMCPAQFLSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZF14</accession>
    <name>A0A3S0ZF14_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 17">Exonuclease 1</fullName>
            <ecNumber evidence="17">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">EGW08_016133</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">EC2010</strain>
            <tissue evidence="21">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">5'-&gt;3' double-stranded DNA exonuclease which may also contain a cryptic 3'-&gt;5' double-stranded DNA exonuclease activity. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for DNA mismatch repair (MMR).</text>
    </comment>
    <comment type="function">
        <text evidence="17">5'-&gt;3' double-stranded DNA exonuclease which may also possess a cryptic 3'-&gt;5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="17">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="17"/>
    <dbReference type="EMBL" id="RQTK01000687">
        <property type="protein sequence ID" value="RUS76102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZF14"/>
    <dbReference type="STRING" id="188477.A0A3S0ZF14"/>
    <dbReference type="OrthoDB" id="26491at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09908">
        <property type="entry name" value="H3TH_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09857">
        <property type="entry name" value="PIN_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000011">
        <property type="entry name" value="exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000096">
        <property type="entry name" value="Exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037315">
        <property type="entry name" value="EXO1_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044752">
        <property type="entry name" value="PIN-like_EXO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF8">
        <property type="entry name" value="EXONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 17" id="KW-0228">DNA excision</keyword>
    <keyword evidence="14 17" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13 17" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12 17" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="10 17" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 17" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="20">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="19">
        <location>
            <begin position="138"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="434"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="543"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="594"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="762"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="852"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="920"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="477"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="555"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="594"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="693"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="707"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="791"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="925"/>
            <end position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00055562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU910737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RUS76102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1026" mass="112934" checksum="E13499AC33A7A059" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZFA1</accession>
    <name>A0A3S0ZFA1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_014701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000573">
        <property type="protein sequence ID" value="RUS77547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZFA1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS77547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="216" mass="25052" checksum="14F963BCAD5F6553" modified="2019-04-10" version="1">MERLKFSPIVRFEPGTSRLGVQRSNHLNNHPLQECEMNEHCRENVNILSSGFSASGSQVRSINHWYILSTPVVHNDGDDDVGNDGDDDDDGDDGDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDEGRRRRRRRRTRRRRRRRRRRKRVPDWQAATIGHYNVSQRGVENLEYGLFSEMLEGCPNGGSPRDAGHGWTREDTRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZJA0</accession>
    <name>A0A3S0ZJA0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_016153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000688">
        <property type="protein sequence ID" value="RUS76079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZJA0"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS76079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="117" mass="13680" checksum="60D64CD07414896A" modified="2019-04-10" version="1" fragment="single">WFVGCLVGWLVGWLVVGWFAGLLVGWFVGWLVCWLVGWLVGWLVGWLVGWLLVGWLIGWLVYWLVGWLVDWLVDWLVGLLVGWFIVDWLIDWLVGLLVGWFIADWLIDWLVGLLVGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZK95</accession>
    <name>A0A3S0ZK95_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_015489</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin AB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000638">
        <property type="protein sequence ID" value="RUS76758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZK95"/>
    <dbReference type="STRING" id="188477.A0A3S0ZK95"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20507">
        <property type="entry name" value="CYCLIN_CCNB1-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20509">
        <property type="entry name" value="CYCLIN_CCNB1-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000154">
        <property type="entry name" value="Cyclin-B1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000005">
        <property type="entry name" value="G2/mitotic-specific cyclin B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="212"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="305"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="309"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS76758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="436" mass="49171" checksum="681544578ABE7B34" modified="2019-04-10" version="1">MAEFPSQMHSGVGHMDTFSKFINSKEEHGISRLTLGDIGNRVSAITIDTKKGGAVKKEILQPINSVFTGKNRESSAISSSVLNHVDINHGFIPSHSDNPSMVTDNAPVKVEWMPGHNLLLQTQREPEFVFSAMVPQPPPMDISDDGDAFSKAMLAEGVEDVDAEDVDNPQLVSLYVNPIYSYMRQLEIKFSIRPNYLEGTGLTGKMRAILIDWLCQVHGRFHLLQETLHLTVAIIDRYLQVKPCTKNRLQLVGVTSMLVASKYEEMYTPEVADFVYITDNAYTKKDVRDMEQDILRTLDFSFGRPLCLHFLRRYSKAGRVDATKHTLAKYLMELTIIELDMAHIRPSHIAASALYLSMLVLDESRWTKTLQYYSSYSEEELIPLARRLAKLVLKAESSKFTAVKTKYSGSKFMKIALIPQLKTRIMLEMAASVPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZKA7</accession>
    <name>A0A3S0ZKA7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_012560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000435">
        <property type="protein sequence ID" value="RUS79676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZKA7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS79676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="105" mass="13093" checksum="29AD83C4EF6A8270" modified="2019-04-10" version="1" fragment="single">KPHIWLFFLEYLIRKAPFSLFFLEYLIRRDPFSLFFLEYLIRRDPFSLFFLGYLIRKAPFSLFFLEYLIRKAPFSLFFLEYLIRRDPFSLFFLGYLIRKAPFFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZM91</accession>
    <name>A0A3S0ZM91_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DJ-1/PfpI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_011224</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000360">
        <property type="protein sequence ID" value="RUS81019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZM91"/>
    <dbReference type="STRING" id="188477.A0A3S0ZM91"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046295">
        <property type="term" value="P:glycolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903189">
        <property type="term" value="P:glyoxal metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010646">
        <property type="term" value="P:regulation of cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023051">
        <property type="term" value="P:regulation of signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03135">
        <property type="entry name" value="GATase1_DJ-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000022">
        <property type="entry name" value="protein deglycase DJ-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006287">
        <property type="entry name" value="DJ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01383">
        <property type="entry name" value="not_thiJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF12">
        <property type="entry name" value="PARKINSON DISEASE PROTEIN 7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="3">
        <location>
            <begin position="52"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS81019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="234" mass="24845" checksum="E0C64CFB523003A7" modified="2019-04-10" version="1">MLRPSHIALSPKVHFFLQRHLLSSPSNSKQPCLSILASNRLFSKSIKNNMPSALVFLAEGAEEMETVISVDVLRRGGIDVTLAGLNGTEPVLCSRNVKVVPDKSLAEALKAGPYDVLVCPGGLKGAQNLSASSEVGKALQDQEKAGRFVAAVCAAPTALLAHGVAKGKKLTSHPSVAEKLTGNYKYLDDRVVVDGKLITSRGPGTCFEFALAIVEQIQGKDKAKSLVDPMLVKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZRG3</accession>
    <name>A0A3S0ZRG3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_007249</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000186">
        <property type="protein sequence ID" value="RUS85004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZRG3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS85004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="208" mass="22575" checksum="172E03AB82CE2A6B" modified="2019-04-10" version="1">MEIEDRGLVPSSHSQSSLWLVTVLCLACLSASSLILNAVLSVAVLRSGRRHQGAVRRAVKRAVKRALGRALRRNSDNDDEDESDVRGSEGGLFMQEPLTSSSDSGPTRRGGQTSSVARLARVGPPGRAKGFAWHKLFPFKSLTWRSNKSPSKSGPLVETKTEQLFPLLNQKKNGGRGVFPQDYTSSDQDVEDLFTAPRRVGETALGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZSW8</accession>
    <name>A0A3S0ZSW8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_006291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000155">
        <property type="protein sequence ID" value="RUS85962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZSW8"/>
    <dbReference type="STRING" id="188477.A0A3S0ZSW8"/>
    <dbReference type="OrthoDB" id="6155250at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS85962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="573" mass="60683" checksum="D3229781F27991A8" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZV35</accession>
    <name>A0A3S0ZV35_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_008656</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000238">
        <property type="protein sequence ID" value="RUS83602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZV35"/>
    <dbReference type="STRING" id="188477.A0A3S0ZV35"/>
    <dbReference type="OrthoDB" id="6239317at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000026">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF13">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="221"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="9">
        <location>
            <begin position="298"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS83602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="815" mass="92383" checksum="4CFBB987D9258F49" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZX61</accession>
    <name>A0A3S0ZX61_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_003986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000089">
        <property type="protein sequence ID" value="RUS88220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZX61"/>
    <dbReference type="STRING" id="188477.A0A3S0ZX61"/>
    <dbReference type="OrthoDB" id="10045473at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS88220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="166" mass="18838" checksum="15E60B0F9271A60B" modified="2019-04-10" version="1" fragment="single">HLPQVRKPHTHTHTHTHTLHLPQSLSPTGIPLPTPSLHNVVTVEETEEQDLSSELHHNYGVSKAVHNMPEELQQKLSLHHHHQQQQQQHHHHHHLQQQQQQQHSSHQPVSPQQSGRGRRTSGLLSPVERGSHRDSFKDVTALHLPSERFSPVRRASDGSAISGKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A0G6</accession>
    <name>A0A3S1A0G6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_004663</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000107">
        <property type="protein sequence ID" value="RUS87557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A0G6"/>
    <dbReference type="STRING" id="188477.A0A3S1A0G6"/>
    <dbReference type="OrthoDB" id="546826at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF564">
        <property type="entry name" value="MACROPHAGE-STIMULATING PROTEIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018643008" description="Protein kinase domain-containing protein" evidence="11">
        <location>
            <begin position="26"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="415"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="724"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="763"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="724"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="774"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS87557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="853" mass="92470" checksum="2317CEC50B419271" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A469</accession>
    <name>A0A3S1A469_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_009877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000289">
        <property type="protein sequence ID" value="RUS82362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A469"/>
    <dbReference type="STRING" id="188477.A0A3S1A469"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS82362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="237" mass="25126" checksum="9B6C390FD0AD30B2" modified="2019-04-10" version="1" fragment="single">LLKLSGLCSANIDSHKLSGLCRANIYLHTISGLCSANIYSHKLSGLCSANIYSHKLSSLCSANIYSHKLSGLCSANIYSHKLSGLCSANIYSHKLSGLCSANIYSHKLSGLCSANIYSHKLSGLCSANIYSHKLSGLCSANIYSHKLSGLCSANIYSHKLSGLCSANIYSHKLSGLCSANIYSHKLSGLCSANIYSHKLSGLCSANIYSHKLSGLCSANIYSHKLSSLCSANIYVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A4P1</accession>
    <name>A0A3S1A4P1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_009568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000276">
        <property type="protein sequence ID" value="RUS82665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A4P1"/>
    <dbReference type="OrthoDB" id="6022562at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027878">
        <property type="entry name" value="DUF4551"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35354">
        <property type="entry name" value="RGD1561648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35354:SF1">
        <property type="entry name" value="RGD1561648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15087">
        <property type="entry name" value="DUF4551"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS82665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="170" mass="19215" checksum="5D632A915334A2E8" modified="2019-04-10" version="1" fragment="single">MAWKAGNGELFQKNSKFESFLKRSISDEAFERVRAYESCIVISEKENKAFKYVVLTDEKIYLTENPPKTLQEVVHFKDVISVDLVNEFPDFLVGQERTNTQQIAVTYTTSEPRRRSLRRSKRSPRGSLTELNGDRSNASTPLGYSSSLDSNSIFHEDAGYGTQSSGSLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AAE1</accession>
    <name>A0A3S1AAE1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_005574</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000131">
        <property type="protein sequence ID" value="RUS86700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AAE1"/>
    <dbReference type="STRING" id="188477.A0A3S1AAE1"/>
    <dbReference type="OrthoDB" id="6149033at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF13">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="238"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="366"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS86700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="487" mass="56069" checksum="A03C8BF562B02087" modified="2019-04-10" version="1">MSRSQSQSQNELIRLLREQMSQQQQQMEALLALVQQSKPAITNTKFGEFDPSIELWADYWARFETFTKANAIPDERRAEIFLTNQTNSIYKLVKNLAQQQTPPRDVNNLTMAEIETYMADQFNPKRFVVRERFKFWTNTERKPGETVHELAARIRQEAATCDFASISDPLDEAMRTRFVCSIHNESTIKALFKIKNDELTFTRAIEIAAEAEEATRVAKETLGTREVEMHKLFKRKPATKPFVHKPQQPQQNQQNWQQQQHRKGSHQRPTQRRCSRCDGAHTPESCRFATAICRFCNIKGHIEAACRKKKHQKVKIVKTVRGSAAKPLTQQCFLSGHPVRLEVDTGSRDNFISLSTWHQIGRPKMSPTSNQYRPLASGSSPSELLNGRQIRTKLDVIVPAQRLTPATVRREPAPARRLTNDSPCFALSYKAGRRDTWRPAVVTAYLGHQLFEVRVLPDGPTWRRHVDQLRPRHARHQHGHIVNSDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AQ42</accession>
    <name>A0A3S1AQ42_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_023451</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01002012">
        <property type="protein sequence ID" value="RUS68788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AQ42"/>
    <dbReference type="STRING" id="188477.A0A3S1AQ42"/>
    <dbReference type="OrthoDB" id="6103485at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF59">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018715522" description="G-protein coupled receptors family 1 profile domain-containing protein" evidence="11">
        <location>
            <begin position="17"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="1"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="74"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="178"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS68788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="372" mass="41163" checksum="E7A41D749F4830D1" modified="2019-04-10" version="1">MMFLAVVFCYISIAIKVRNTKRVGSVPDGQVTLSTARSAEDDDFTATSQDHTHKEVAPEMSLERRNAILSEELSAPCDPDKSTRSRDGHVTFQTQDSNNIDQPPHRQSGQSLAVKTLSIAVTTISDLKFLPNAGTSDGGKQLLFLPGTSQPVPNGTDELAHSSSTIELPLTVMGNNGSGSTGSDGIGRGNLLKVEPQISGSRQESSKSRVAQMSKRKMEARQQRNLRVTRLLFVVTTVFILSWVPPYMAMVKGFYIGYSFPMSLAEFVVLSYGPSMYVINTFSNPIIYAALSAIYRRHVTDMFQAMWKTIPYKDLPATVPPPVGSSYTSCCRSPRLTPNVRDTQYPTLISTYRYLHVFILMPMVGRRNWCRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AUW8</accession>
    <name>A0A3S1AUW8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_023307</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001917">
        <property type="protein sequence ID" value="RUS68931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AUW8"/>
    <dbReference type="OrthoDB" id="6287314at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS68931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="156" mass="16697" checksum="64FDE2CF08E73D01" modified="2019-04-10" version="1">MTPRAASGKPKLLGSGGSMVAKLKLKGIDGRHEKRLPHPRKAAGAQLTHSRHGEVVTKNNNTGLFSRPRNWNEYTLNPLTRTHWRASLVPAAAVIPAPIAYIKVVAVKKLVVGSQAQAGGPARAGSLPVVSCPTRLPALSRVVLFTERPGWPARLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AXP9</accession>
    <name>A0A3S1AXP9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_022287</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001529">
        <property type="protein sequence ID" value="RUS69945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AXP9"/>
    <dbReference type="STRING" id="188477.A0A3S1AXP9"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS69945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="186" mass="20558" checksum="C35F48C25894962C" modified="2019-04-10" version="1" fragment="single">THIMTKQTILITGCSHGGIGYATAKYLHELGHIVFASVRRQAELDQLTAEGINTYLLDVCDYKQFDNVLEQVLEKTGGTLDVLFNNAGYGQAGALEDIETKYLIEQFNTNVFGLHHATRQVMKVMRKQGYGKIIQHSSVLGLVTMRYRGAYCASKYAIEGITDVMRQELAGSNIFMSSLNTGPVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AXT8</accession>
    <name>A0A3S1AXT8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_021124</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001270">
        <property type="protein sequence ID" value="RUS71119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AXT8"/>
    <dbReference type="OrthoDB" id="6112736at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019430">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10328">
        <property type="entry name" value="7TM_GPCR_Srx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="346"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="44"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="281"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS71119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="387" mass="43198" checksum="99726FEBA71D2E64" modified="2019-04-10" version="1">MVNQTFLITRTANSSGLLYHREQLLSLEILSPVWPALIVLGLVSNTTNICVFVRTGLGDSVTILLLSLSVSDALFLVLITPTVATFVIFHFRADWTWPVDPAITHTLFYWPAFTFYDFSSYISVFLGVTRCACVAMPLHFKSTFTRRRTLLGIVCLFGLAIFLHLPVMTIFSIGWRRDASTNFTHTLYPVLVTSGRQAMVKVNDILNRNSLPWVSFVAMVTCVALLSFKLFQSSQIRFLHVSKPATSGEAKTSSEKKTSGEVRTYGPVIPSRKARHDATITTTTNNNSSSNNNNNNNKLSPKDVRVVQSVVLVCSIFIVAQVPAILYSTVRVVNPDFDHGGRLVNLFGIIAYVSLTFSLLNATLNLCVYYNYNSRYRSVLRSILKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AY33</accession>
    <name>A0A3S1AY33_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_020931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001235">
        <property type="protein sequence ID" value="RUS71312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AY33"/>
    <dbReference type="OrthoDB" id="6150112at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS71312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="138" mass="15671" checksum="1AD2AD8489646BBB" modified="2019-04-10" version="1" fragment="single">MEAESGKQRSRQKRRERALQLQQEKQTKEEDEEEEASGQDDHGESSPRSSKDNKTRLKPKKNKSALFEEDIIDGFAIISFKTLEDLEIVSKKNGCIKNKSARLPEEKGSAKDIHNALDNTIKLEDSNTGKAKKKKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AYD1</accession>
    <name>A0A3S1AYD1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_020754</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001204">
        <property type="protein sequence ID" value="RUS71503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AYD1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS71503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="138" mass="15944" checksum="04631242401CBD58" modified="2019-04-10" version="1">MLFEWRKTYRSVPFESNKTIMPIVVARDVHDRAIRFGQDDHAVRAVRGCRKIMPSEPRKDLVDHAIRAVRGCRKIMPSESRKDLVDHAVRAVRGCRKIMPSEPRKDLDDHAVRAVRGCRKIMPSEPRKDLVDHAVRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AZV6</accession>
    <name>A0A3S1AZV6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_023809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01003010">
        <property type="protein sequence ID" value="RUS68429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AZV6"/>
    <dbReference type="OrthoDB" id="6155671at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS68429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="241" mass="26039" checksum="7F24449768C32DE9" modified="2019-04-10" version="1">MRRPRFGARRFRVGWHSTANSELRRAGLAPLDSGIKRGIAVRQGPLGVPTVRRAQSALKTVSGGEFDWGGTSVKSLPTPASGGNDMAALEFAPRRLVEPRQEVFTVPPISAGGNLYDIHPMRRGGDKSFVDDLVLGRGVVISRAATSLRSVETQPLTRRFVRIRRATISDDGQGQYQNATSNFFGARRVDRGTARAKPPSVRARVRRGLARPSQAGAARSITAMAGAKARRGRASMAWALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B067</accession>
    <name>A0A3S1B067_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_019325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001001">
        <property type="protein sequence ID" value="RUS72905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B067"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS72905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="118" mass="13449" checksum="2C3E2BF1D2D6001E" modified="2019-04-10" version="1" fragment="single">MTLRFVTYHLNVSLGEITLLLSHEIYNNLATSYGFWQRNEQPLDKPAPRCFVNLLGTVGCTDDQNAIFRLSCRAILPSNQTRIRPLRQQRVDLIDENDGRLVASGDSEQRAHHLLTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B4T6</accession>
    <name>A0A3S1B4T6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Potassium channel tetramerisation-type BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_020279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001135">
        <property type="protein sequence ID" value="RUS71966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B4T6"/>
    <dbReference type="STRING" id="188477.A0A3S1B4T6"/>
    <dbReference type="OrthoDB" id="9989223at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.80:FF:000002">
        <property type="entry name" value="Potassium channel tetramerization domain-containing 9a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051082">
        <property type="entry name" value="Pentapeptide-BTB/POZ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14136">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14136:SF17">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Potassium channel tetramerisation-type BTB" evidence="1">
        <location>
            <begin position="15"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS71966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="277" mass="30604" checksum="AAAF9B57FABF0F0A" modified="2019-04-10" version="1">MLARMFCNDKVVGWSSRVDESGAYLIDRSPLYFEPILNYLRHGKLILDKNVNPEGVLEEAKFFGLTSLIDTLEEIIEREQKPDDNTPITRRDLVLRLLSTPTNQELRCQGMNFTGANLSKLDLRFINFKYAILRSANLSGANLSFCNFERADLGKAIVDSANLLGVKMLCANLEGTSMRGCYFEDPAGSRANMEGALMKNVDLEGSHMAGVNLRVATLKNANLQNCDLRGAVLAGADLENCDLTGCDLQEANLRGANLKGATFELMLHPLHMAQAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BAK3</accession>
    <name>A0A3S1BAK3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription initiation factor IIF subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_013271</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TFIIF alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000479">
        <property type="protein sequence ID" value="RUS78969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BAK3"/>
    <dbReference type="STRING" id="188477.A0A3S1BAK3"/>
    <dbReference type="OrthoDB" id="76676at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001096">
        <property type="term" value="F:TFIIF-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008851">
        <property type="entry name" value="TFIIF-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011">
        <property type="entry name" value="TFIIF-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05793">
        <property type="entry name" value="TFIIF_alpha"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="210"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="417"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="248"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="291"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="322"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="417"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS78969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="533" mass="60614" checksum="B79FCBF6EB29DFA3" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BCY6</accession>
    <name>A0A3S1BCY6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_011164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000356">
        <property type="protein sequence ID" value="RUS81078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BCY6"/>
    <dbReference type="OrthoDB" id="6074739at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS81078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="121" mass="13811" checksum="FDA185CFA9556B9B" modified="2019-04-10" version="1" fragment="single">SPRSRATDNPSSDDEGYRTARSGGEDLLLEDLKEKLRPVIDHRMPTLVTKRGMYAPDPASAAIQVANLTRRQNYLFSKGKESKFLAEPPRNMHFLREAIFQEIKLISKALSAVEREYYGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BDM7</accession>
    <name>A0A3S1BDM7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hexosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_013872</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="RQTK01000515">
        <property type="protein sequence ID" value="RUS78352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BDM7"/>
    <dbReference type="OrthoDB" id="2139606at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF314">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS78352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="221" mass="24619" checksum="215DC66A61844737" modified="2019-04-10" version="1">MLSPKSLEDVIPLEKTHGLVSGAPSSLRLTQGKQSQNISKGSAHESHGLTTVTSRTSNDFLGYKSSCSLQNISKPYFDYIEDNITGINMTFFKLSDSKVSEIPMSFPSQASHICSRGLPSIVFAVPSVVNSSQDRLEIRQTWASDFYGDNWEQTSQRRIAFFFGSSGLSATDMATLRTESEKYRDIVIGDFHDTYTNLSLKMAVTISWVAKYCPDITLWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BI39</accession>
    <name>A0A3S1BI39_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein quiver</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_008075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000215">
        <property type="protein sequence ID" value="RUS84188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BI39"/>
    <dbReference type="OrthoDB" id="6136973at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS84188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="12909" checksum="646FD90FAFE15CE0" modified="2019-04-10" version="1">MCSSCRSDEYPKCEIDPPPPQPCKELGSGGVESCSTVRIFNEETGKLTQFLRSCSDSLKQETPCFNQRPGYKTCADICYTDGCNAAPSVSSPTSMHFARVLMGLFLTAFFVKLKNATC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BIZ9</accession>
    <name>A0A3S1BIZ9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_010302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000314">
        <property type="protein sequence ID" value="RUS81916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BIZ9"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS81916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="119" mass="13619" checksum="E7DF56AB6E471CB3" modified="2019-04-10" version="1">MMLHDFSQIFFYLQSETKIAQNFTNGDVLSRLSRGGCQDKRLRIVRAGTHKQGRCIQTPVPAATFSVDRQRSTKHHCQSHPFTFFKVQKKHLIVKPHNTTIVTASRTLASVLQHWSSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BLN1</accession>
    <name>A0A3S1BLN1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">IRF tryptophan pentad repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_008515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000233">
        <property type="protein sequence ID" value="RUS83719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BLN1"/>
    <dbReference type="OrthoDB" id="6538197at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001346">
        <property type="entry name" value="Interferon_reg_fact_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019471">
        <property type="entry name" value="Interferon_reg_factor-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11949">
        <property type="entry name" value="INTERFERON REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11949:SF17">
        <property type="entry name" value="IRF TRYPTOPHAN PENTAD REPEAT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00605">
        <property type="entry name" value="IRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10401">
        <property type="entry name" value="IRF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00348">
        <property type="entry name" value="IRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01243">
        <property type="entry name" value="IRF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51507">
        <property type="entry name" value="IRF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IRF tryptophan pentad repeat" evidence="2">
        <location>
            <begin position="15"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS83719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="549" mass="63214" checksum="7B4489791A5D3CC3" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BLS8</accession>
    <name>A0A3S1BLS8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_008420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000229">
        <property type="protein sequence ID" value="RUS83808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BLS8"/>
    <dbReference type="OrthoDB" id="10262962at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS83808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="508" mass="55616" checksum="6C7F696B98E65B3A" modified="2019-04-10" version="1">MSGDRLRLREKDAGSSSHGAVTDPDCGIVVNSRDVFLILTEAPLQEEIHIHEYQKSVPIPSGGERIQDYQLEKAFIAVTPGHTSTPADIVKALEGHRSEKVRAYPELLSIKRVVRGSSSKSAFKIFEALPSGTYRTTQKSFGGKEKKQDRTEGGKVEEELSVVGVVQLIKLGEFLSSRYFEQLHSVGAPPGESENLAETTGKLVHFQTLSAFLHGLLMEKQFVATNVAKVGASYCQVAGQLGSICSAAHSALQHLHFFVKEAFRKETVLFKDSKLSGLNVAALLSEGPNDLSAKDAISHVSDRLCAERHHRRVERVRKNPIQVSNADIDLMFNISDSHVAYLSSSEAFQSFARSHSLSLLSFADQWLTCSPRAGSHSGSGGCRDKNDLKTVSIEPLSMLSLLTTLSLPTSQHILPAARLVIEVFNLKSSNNSEEISGSLGYVSEQTQHRKINKSDPAHVRNSFSEVPKMSWNVLNKKVLYLKRKGLFGSCTMGGWSLLKSLCALANLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BNX7</accession>
    <name>A0A3S1BNX7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_006962</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000176">
        <property type="protein sequence ID" value="RUS85261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S1BNX7"/>
    <dbReference type="OrthoDB" id="1594986at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13243">
        <property type="entry name" value="PH_PLEKHG1_G2_G3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043324">
        <property type="entry name" value="PH_PLEKHG1_G2_G3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45924">
        <property type="entry name" value="FI17866P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45924:SF2">
        <property type="entry name" value="FI17866P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="123"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="262"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="497"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="598"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="688"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1087"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1150"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1362"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1402"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1571"/>
            <end position="1633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1740"/>
            <end position="1829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1842"/>
            <end position="1863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="315"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="342"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="397"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="504"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="536"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="598"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="614"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="690"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="702"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1087"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1104"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1164"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1188"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1362"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1404"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1436"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1571"/>
            <end position="1584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1596"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1606"/>
            <end position="1622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1768"/>
            <end position="1780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1793"/>
            <end position="1806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1810"/>
            <end position="1822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1842"/>
            <end position="1858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS85261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1890" mass="207517" checksum="E6FD8E4FAB00313E" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BQ56</accession>
    <name>A0A3S1BQ56_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_003432</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM227 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000073">
        <property type="protein sequence ID" value="RUS88802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BQ56"/>
    <dbReference type="STRING" id="188477.A0A3S1BQ56"/>
    <dbReference type="OrthoDB" id="73353at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029417">
        <property type="entry name" value="FAM227"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33560">
        <property type="entry name" value="PROTEIN FAM227B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33560:SF2">
        <property type="entry name" value="PROTEIN FAM227B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14922">
        <property type="entry name" value="FWWh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="493"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="449"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS88802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="518" mass="59121" checksum="B30660900E5F77EF" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BR65</accession>
    <name>A0A3S1BR65_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SEA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_005555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000131">
        <property type="protein sequence ID" value="RUS86681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BR65"/>
    <dbReference type="STRING" id="188477.A0A3S1BR65"/>
    <dbReference type="OrthoDB" id="6150203at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.960">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036364">
        <property type="entry name" value="SEA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01390">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00200">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82671">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50024">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEA" evidence="2">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="SEA" evidence="2">
        <location>
            <begin position="618"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS86681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="680" mass="74811" checksum="895A572793AC4319" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BR95</accession>
    <name>A0A3S1BR95_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">E3 ubiquitin-protein ligase synoviolin-like TPR repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_019238</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000988">
        <property type="protein sequence ID" value="RUS72990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BR95"/>
    <dbReference type="STRING" id="188477.A0A3S1BR95"/>
    <dbReference type="OrthoDB" id="7759664at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057992">
        <property type="entry name" value="TPR_SYVN1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF184">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SYNOVIOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25563">
        <property type="entry name" value="TPR_SYVN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="E3 ubiquitin-protein ligase synoviolin-like TPR repeats" evidence="11">
        <location>
            <begin position="4"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS72990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="134" mass="15659" checksum="A8A1DFB8108E3A32" modified="2019-04-10" version="1" fragment="single">MRSLVLTGFSFMLTASVIGNAYYQKKQFYPSVVYITKSNPSMAVMYVQALVFVVLMGKMLRAVFFGQLRAAEMEHLIERSWYAVTETCLAFTVFRDDFSPRFVALFTLLLFLKCFHWLAEDRIDYMERSPTISW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BSF9</accession>
    <name>A0A3S1BSF9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_004544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000103">
        <property type="protein sequence ID" value="RUS87703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BSF9"/>
    <dbReference type="OrthoDB" id="371494at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36489:SF2">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36489">
        <property type="entry name" value="PROTEIN-COUPLED RECEPTOR GPR1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS87703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="197" mass="22648" checksum="48FB9D290E6D249F" modified="2019-04-10" version="1" fragment="single">PNKQQTNKQTYQRTNKLTNQPTKQEIYQPKNKFTNQPTNQITNKLTKQTTNQPTNKFINEPTNQPTNLPVNLTTNQTIKLSTKQTNLPTNQPSKKLTNQQTYQPTSKPTNKITNQPTNKLTNQLTKQQIYQPTNLPNNKITYQLTNQITNQTTNLPTNQPTNLLTNQPTTKILTNQTTNQDTHQPTNHPSNPTHLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BUD0</accession>
    <name>A0A3S1BUD0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">IQ domain-containing protein K</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_003278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000070">
        <property type="protein sequence ID" value="RUS88942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BUD0"/>
    <dbReference type="STRING" id="188477.A0A3S1BUD0"/>
    <dbReference type="OrthoDB" id="2155538at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22969">
        <property type="entry name" value="DD_IQCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043408">
        <property type="entry name" value="IQCK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34927">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34927:SF1">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS88942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="31901" checksum="21880441A74E0ADA" modified="2019-04-10" version="1">MSVITKVAEPNLWQEICKEFASQRPPFDKDDDSASVTTDYLDYDPAQHHPVFYGKMFAGVCDIDSDATAEFDPAISHPSCLGYSFTSKPPSICAPPPPQPLNRFSCTPTQYLNTYIYPTLLPALEAMLKQAKLEKCFEAKKLDEATRRRTKFNACDYITEYLYKNNPNPHNSDRSKVDLWEIPFVKEWLKDHPRPPLPKSLIWTDEEATLIIQSYWRGYLVRKEPDVQELRVWQREWREENRGIQSRVSEFWDKQMPDGDGAAVAENNPQEKEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BVC2</accession>
    <name>A0A3S1BVC2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_002636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000051">
        <property type="protein sequence ID" value="RUS89618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BVC2"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS89618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="233" mass="25792" checksum="47925100D03E1404" modified="2019-04-10" version="1">MFTWITLHFANPFHLTPEHHKRCDPGSNYSCFLLVSFHLMVETDLTHLTTEHCRLLVLFACWDCPVCFRERLVENQTGCNRVGKGVRCLSVENPDTADRLGSCQETEQNTPMYLARSARQSSARESMVAVEVAATVGAVSLGMRTLTGSAGRAGHTLGQRKASQRGQDDGGGGGGDDDDDNDDDDDDDDDDDDDDDDDDDDDDHDDDDDDDDDDDDEMIGFDEDGMRFLINLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BYD1</accession>
    <name>A0A3S1BYD1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_000334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000004">
        <property type="protein sequence ID" value="RUS91932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BYD1"/>
    <dbReference type="OrthoDB" id="10395169at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS91932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="235" mass="27161" checksum="EFCBEF9CCBBA4A7A" modified="2019-04-10" version="1">MNSARPIAVGPCRLFKKQCELRPRSAVVWFKSLLVRRSNQSEKCLLGEWVDSFLTLYSDSTLCVRGGNCERSQVVAIVKLVDVYRQLLFGESLCVPKEVPTVSNKFRSSMLGVPNQLTNNTHMIWLYFFSKHTLNKWLVAFCRAIPTELLNEFKVAKACYHQLKKMKRDPPSLALKNHIHLFFPSREFDPEAGSPPMNDFKISVLPNRQRPRHSKSKKHRKRINKCSRGSRSQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C0J3</accession>
    <name>A0A3S1C0J3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_012633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000440">
        <property type="protein sequence ID" value="RUS79608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C0J3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598:SF1">
        <property type="entry name" value="4FE-4S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45598">
        <property type="entry name" value="PROTEIN CBG11839-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS79608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="192" mass="21203" checksum="A69F21B54B83CE8C" modified="2019-04-10" version="1">MPGIYNMLSFIVNSFLHTDYITYFETSKKLFCRIVGDCKHSPIVLYGGRIERVHLQVCDRKGNFVWKIYTEFQAGQNSYFSLSLPLSLSLSFSLSLSLSISLSPSLSHILSIFLSLSLSLSPSLSPPLPLSPSLSHSLPPISPSLYLPPPLSLSLSLSLSIYLSLSPCYVMRQPILIQALAVFDKIRASVCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H142</accession>
    <name>A0A3S1H142_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Metalloendopeptidase</fullName>
            <ecNumber evidence="7">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_022133</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6 7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="7"/>
    <dbReference type="EMBL" id="RQTK01001490">
        <property type="protein sequence ID" value="RUS70108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H142"/>
    <dbReference type="STRING" id="188477.A0A3S1H142"/>
    <dbReference type="OrthoDB" id="6061307at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="9">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="164"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="179"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS70108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="232" mass="25357" checksum="17020AB9BBE6092D" modified="2019-04-10" version="1">MVGGAQTVGLAPGCRVKGVIIHEVGHALGLHHEQTRPDRDQHVQIIRANIPGHLYYNFEKYSWNIIRNMGIPYDYTSIMHYGKTAFSTNGRLTIRTLDSKYQNVIGNRNDLSFKDIKSINIMYNCKRATSGCTKTDAQCSGEGFVGKDCKCWCPGNPYTLCSGGGGGGGGGAGRRRWEVEEEEEEVEVEEEEEEEEEEEEVEEVVVVERALTGTGAAATGPVSASAPETPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H2D8</accession>
    <name>A0A3S1H2D8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Methionine aminopeptidase 2</fullName>
            <shortName evidence="11">MAP 2</shortName>
            <shortName evidence="11">MetAP 2</shortName>
            <ecNumber evidence="11">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EGW08_021406</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">EC2010</strain>
            <tissue evidence="15">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="11"/>
    <dbReference type="EMBL" id="RQTK01001325">
        <property type="protein sequence ID" value="RUS70835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H2D8"/>
    <dbReference type="STRING" id="188477.A0A3S1H2D8"/>
    <dbReference type="OrthoDB" id="7848262at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01088">
        <property type="entry name" value="MetAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000106">
        <property type="entry name" value="Methionine aminopeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03175">
        <property type="entry name" value="MetAP_2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050247">
        <property type="entry name" value="Met_Aminopeptidase_Type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018349">
        <property type="entry name" value="Pept_M24A_MAP2_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777:SF2">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01202">
        <property type="entry name" value="MAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11 12" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="14">
        <location>
            <begin position="181"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RUS70835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="492" mass="54265" checksum="10ABD515567B46DA" modified="2019-04-10" version="1">MAAVKVDESEDLNQNDELHEVKAVENDAVDQEECGEQSKKKKKKRKKKKNNAEGEAGETVECDEQVEAVANEVEAVKLNGDAESSSQKAPEGEDGGDGAEGENKKKKKRNKKKKGGGAGGGTGKQQTVPPSIPIVELFDEGAYPVGEICDYPPVNDGRTAKNRVLTEEMKVMDESQSHLYEDMRIAAEAHRQTRQYMKSIIKPGMTMFNICEELESTARKLIKENGLDAGLAFPTGCSLNHCAAHYTPNAGDPTVLGYDDVCKIDFGTHINGHLVDCAFTLTFNPKYDQLLAAVKDATNTGIRAAGIDVRLCDVGEQIQEVMESYEVELDGKTYQVKPIRNLNGHSVGQYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGHVHDDMETSHYMKNFEVGHVPLRLAKSKQLLNVINQNFGTLAFCRRWLDRLGQTKYLMGLKNLCDVGILDPYPPLCDQKGCYTAQFEHTIILRPTCKEVVTRGDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-05-03" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H3Q9</accession>
    <name>A0A3S1H3Q9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_020620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001187">
        <property type="protein sequence ID" value="RUS71609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H3Q9"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS71609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="244" mass="28291" checksum="9938D2FDC0533163" modified="2019-04-10" version="1" fragment="single">ESNEEGRYRRLEGYAIRTFRVAQNDDFLWFQTPIERDPDATLYDMFEVSARISPPTKSKSASPMVTLFRIESEKVNKRLEVCAYNSPYRGLTLRKPDTIADAYVGVKSAGGKFYKRKVQFPHPDQTLEVARQLHTFAHKCQASLRSGNGLTSLVALAQELDEEQLPYQLVQSCYDVVKTYLVSPKRHVGELKNAFYIQHMMFMSVDSDRPTESAIEYLENLDFTKRRIFNESLQTTEELYKFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HA71</accession>
    <name>A0A3S1HA71_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_016979</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c oxidase VIIa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000757">
        <property type="protein sequence ID" value="RUS75264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HA71"/>
    <dbReference type="STRING" id="188477.A0A3S1HA71"/>
    <dbReference type="OrthoDB" id="6084861at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.91.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036539">
        <property type="entry name" value="Cyt_c_oxidase_su7a_sf"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS75264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="89" mass="10261" checksum="CB48743CD1BD73DF" modified="2019-04-10" version="1">MLGRLFLRRMSSLAEPLPRPGQGVYKVPNEPRYKKLMETQTLFCRDDGRLVWQKLPSDMMLYYLSVGLVVAGTVLTFDVFRRLASPPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HAZ1</accession>
    <name>A0A3S1HAZ1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_016579</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Microsome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000721">
        <property type="protein sequence ID" value="RUS75653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HAZ1"/>
    <dbReference type="STRING" id="188477.A0A3S1HAZ1"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11055">
        <property type="entry name" value="CYP3A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050705">
        <property type="entry name" value="Cytochrome_P450_3A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302:SF15">
        <property type="entry name" value="FATTY-ACID PEROXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="8 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0492">Microsome</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS75653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="58242" checksum="D4AAFD4F6E774512" modified="2019-04-10" version="1">MDLTWLLLGLALLLVLAFLVTRYSAWSVRHVFRDLGIETPPSSVFFGHFLEGMKYGIFDVQTHQYKMFKDKKVYGVYEFKTPMIVVRDLDLIKDVCVKHFNNFVDRRVLLNMEPPFHQTLLAILGDHWKKVRSAVSPTFSSGRLKKMCRHIERNAKSLQLVLDARQESGEEVELKEMMSRLTMDTIAGTGFGLDIDSLREPDNEFHTNAQAFTKPNLAVFIVTLMFPFLGKIMESMGIKFLPQKAADFFEKVLDNALRERRESENAGKMHDFLDLMLNAEEHGKEGEACDKHEGVGTLTRNEILSQALVFLLAGYDTVSSVLSFTMFLLAVHPEHQRLVQEELDKKLPLDDSIPDYETVQNLPYLDQCISESMRMFPPGLILDRVCNQEITLHGVRFPKGMPVVLPIYAIHMDPDLWENPKDFKPERFSPEAKESQHQYAYFPFGHGPRNCVAMRLAQLELKIIIATVLRRFDLTPCQKTVYPVQLSSWQLAANDGLWVKPERRATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HF98</accession>
    <name>A0A3S1HF98_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_014045</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000526">
        <property type="protein sequence ID" value="RUS78186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HF98"/>
    <dbReference type="OrthoDB" id="10486046at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="47"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS78186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="348" mass="38622" checksum="AEDBFDC5F782FBE9" modified="2019-04-10" version="1">MLNFSKLSTYLKNESSLVQQIVPIPLRNLFLKINCSVLLLFALAGIPNNILNILIFRKLGFNSNINIHFLFLSTIDLICAIIYACVAVIMLDMSGLIRLPVDLADAIYLTAIVLISLSTIGSWVTAIISVERCCSVVMPVKVKHIFTRKVTICLNAGMVIFQMAIITVNVTSLKFRVNKPLNDGRLQVILVYSDDSLYIALLFWGASLITFICMATVVVSTAFLGTALRQRERWLESLPFSANLSTRVNNRKVARTVVAISSIYITCSIPGVVVLLVLFAVPTLNPFAPAAESLSMVLSTFIQSFLAFSGMANIFVYLNMNSKYKEYFKNLLCFVCAQSRMRYGSDCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HV32</accession>
    <name>A0A3S1HV32_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_005544</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000131">
        <property type="protein sequence ID" value="RUS86670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HV32"/>
    <dbReference type="STRING" id="188477.A0A3S1HV32"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="142"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="252"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="289"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS86670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="330" mass="35592" checksum="07E2DD843FE34526" modified="2019-04-10" version="1" fragment="single">TPLHVAAKVGRADWVDRLLEKGAKVDATDVAGVSPLSSCTTSDSEVCASSLIRHGASVNQRNKDGMTPLHRACAIPRWFHRAKLLSHGSDVNTSCTKGQTPLMSAVSFYYHITFGNKRFVDLLDLCEALVLAGCDLNARDNSGKTALHREVESNNIYGVIFLAHAGCDLNVRNIAGLTPYQTATLPESTKYELARYLLHYGAAPEEDSKDINHPTRPLTYTTLHLVAKAGQTKYVTPALELCKDFLNARNFAGRTPLEEAVRCGHFSTAEHLLESGASLSPDGAVEEQAGSSVLHLAAASGAERLVELLLERGADANATDRYGLTPLRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HXD1</accession>
    <name>A0A3S1HXD1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Domain of unknown function with conserved HDNR motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_004226</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000094">
        <property type="protein sequence ID" value="RUS88060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HXD1"/>
    <dbReference type="OrthoDB" id="10003408at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029369">
        <property type="entry name" value="HDNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35440">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35440:SF1">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15115">
        <property type="entry name" value="HDNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Domain of unknown function with conserved HDNR motif" evidence="2">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS88060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="110" mass="12733" checksum="A6968A558CADE5A8" modified="2019-04-10" version="1">MTKGRKFAPSSASEGIWFRHRGDPADADGRLRDVTSTRQMLEAPFSAPCGLRSPPLLYSQKEEPVYNLRNPFTQHDNRHYFQDKGEYFGNGRTTRSLRKRLEPLEGRLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SI80</accession>
    <name>A0A433SI80_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_023661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01002291">
        <property type="protein sequence ID" value="RUS68577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SI80"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS68577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="133" mass="14884" checksum="14A866E53318143D" modified="2019-05-08" version="1">MSKWIKTQIVFTECPEPSAVGFSFLLVCPVNCPRWSILVSSYSSSLLASYSILDSFLLVCPMSGPRWSILVSSYSSSSLASYSILDSFLLVCPMNGPGWSALPRRWPRTPASCESRRARRSRAECSSCQTWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SIG3</accession>
    <name>A0A433SIG3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_023638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01002244">
        <property type="protein sequence ID" value="RUS68598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SIG3"/>
    <dbReference type="OrthoDB" id="5873669at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33796">
        <property type="entry name" value="HOLLIDAY JUNCTION ATP-DEPENDENT DNA HELICASE RUVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33796:SF1">
        <property type="entry name" value="HOLLIDAY JUNCTION BRANCH MIGRATION COMPLEX SUBUNIT RUVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS68598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="72" mass="8814" checksum="7ACB0FF4AB8FAC2E" modified="2019-05-08" version="1" fragment="single">RPYHVENTGSRPITIVKQRRAWLVLRWVTAWEHHCLRPYHVENTGSRPITEVKQRRAWLVLRWVTAWEHHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SJG0</accession>
    <name>A0A433SJG0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fizzy-related protein homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cdh1/Hct1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_023011</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001770">
        <property type="protein sequence ID" value="RUS69227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SJG0"/>
    <dbReference type="STRING" id="188477.A0A433SJG0"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000025">
        <property type="entry name" value="FIZZY-related 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF1">
        <property type="entry name" value="FIZZY-RELATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="12">
        <location>
            <begin position="166"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="212"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="296"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="426"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS69227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="480" mass="53315" checksum="E7FF2F9CFCAC66FD" modified="2019-05-08" version="1">MDPEYEKRLLRQQNGQLSPYRYPGYTSPITSPNKRMTGDRFIPSRTSPCWNINFDIQHPQSPSSSLKSKDSSNESSKDGLAYAALLRNELLSAGIEDLKDLQTDDKKVLAPKESKNLFKFHSSRRSSSGCDTSPYSLSPVGSKSQKLLRSPRKAVRKISKIPFKVLDAPELQDDFYLNLVDWSSLNVLSVGLGTSVYLWSACTSQVTRLCDLSTDNDTVTSVSWSERGTQVAVGTHKGYVQIWDVAASKKVHTLVGHGARVGALAWNGDMLSSGSRDRLILQRDIRTATTTPERKLIGHKQEVCGLKWSPDHQHLASGGNDNRLFVWNATTSTPLQTHMEHQAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTSQPLHCVDTGSQVCNLAWSKHSNELVSTHGYSQNQILVWKYPSLVQIAKLTGHSFRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRSTKESKSVLNLFTRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SJH7</accession>
    <name>A0A433SJH7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_022980</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001756">
        <property type="protein sequence ID" value="RUS69255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SJH7"/>
    <dbReference type="STRING" id="188477.A0A433SJH7"/>
    <dbReference type="OrthoDB" id="6287421at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF372">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="1"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS69255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="289" mass="32818" checksum="9E25AAD188392899" modified="2019-05-08" version="1" fragment="single">NCLLISVVARNARLHTNTNLLVASLAFTDVLMGVQCCIIGMTGFSVGVRSWLATSDLHIFDVFMLSINLSLIGVSLLHVFSLALDRYLYVLWPFRYRRYVTRRTVLAVAVVSWTLGLVYALLPLALFNGHRHRQLCILMDIPVSFSYVPIGCVYVVCLGVVTYCTAGLVRLAHQHRRGRPRKLIGNGDSKMELKVNFNVKQEQCARFFNRSNLKIIKFVLVVFVSFLVCTFPPVTLLSLDKIFNLSLFSENDFAIDILRFMVMSNSGINFFSITYMNRDFRRALVKSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SKY7</accession>
    <name>A0A433SKY7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_022446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001575">
        <property type="protein sequence ID" value="RUS69789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SKY7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS69789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="375" mass="48366" checksum="EB96601746C4AD4C" modified="2019-05-08" version="1">MKKKKKTKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKEEEEEEEKEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEKEEEEEEEEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SNG9</accession>
    <name>A0A433SNG9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Homeodomain-only protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_021448</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001333">
        <property type="protein sequence ID" value="RUS70789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SNG9"/>
    <dbReference type="STRING" id="188477.A0A433SNG9"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039162">
        <property type="entry name" value="HOPX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21408">
        <property type="entry name" value="HOMEODOMAIN-ONLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21408:SF1">
        <property type="entry name" value="HOMEODOMAIN-ONLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="9 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="136"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="138"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS70789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="200" mass="21995" checksum="2ADD39FC329A3BA2" modified="2019-05-08" version="1">MYNSRSPTSRTAGDFPTSPYHERRSPLETLSPAQRDEFTFAEQSSSSQYEVRSPTSPYSVRSPVSPYDVRSPTSPYDRRSPVSPYDMRAPLSPNDNGFPPSSGKGRSLSSSSAGSCASTGLSGIQAHLSSPSQLPRVSDYQLKSLEANFKDNRNPSELDLTLISAEVGLPESEVKHWFSHRLARWRLHQGLPANSTSICD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SQ83</accession>
    <name>A0A433SQ83_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_020840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001220">
        <property type="protein sequence ID" value="RUS71399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SQ83"/>
    <dbReference type="STRING" id="188477.A0A433SQ83"/>
    <dbReference type="OrthoDB" id="10036174at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049885">
        <property type="entry name" value="MTCL1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15742">
        <property type="entry name" value="GIRDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15742:SF5">
        <property type="entry name" value="GIRDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="603"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS71399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="706" mass="82638" checksum="D6DD717484AF51CD" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SR21</accession>
    <name>A0A433SR21_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_020550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001174">
        <property type="protein sequence ID" value="RUS71692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SR21"/>
    <dbReference type="OrthoDB" id="6162132at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS71692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="206" mass="22449" checksum="A462A6611DF99EDC" modified="2019-05-08" version="1">MPFTHNSAFDGIGFNRGVSHLVPVNQCQKRKSVFDMVDVDHDMIADSQHQWLGASSATKRQRLLEPEQSFFNVMSVGDGDAVVKEANNNNNTNNNNDTIKGPGCPPPAPSLDEEVMEEHTAMDSDFVPDMAQYEPTATTHSSSSSSSSLPSSSSTAQQISSPQTIYGNNERSGLKPSPVSGRLHCLCSASWRGMYGMEAAYMTDYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SR86</accession>
    <name>A0A433SR86_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_020481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001164">
        <property type="protein sequence ID" value="RUS71759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SR86"/>
    <dbReference type="STRING" id="188477.A0A433SR86"/>
    <dbReference type="OrthoDB" id="426654at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="67"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS71759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="152" mass="17657" checksum="810C779D666E423C" modified="2019-05-08" version="1" fragment="single">MKESRLLRVEDYAKLICIFYSKKLDVKIDFVFSVYDFYQDFNISPMEMTALLQTAIVSPGDDEALDQLKELVDMVLQVFDTDGDGMISLGEFRHFVHQNILYIQLLGQVLPHKEIIDSFMDNLKNKSALEVRSEFLFERTDCLSEPRPPQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SUG5</accession>
    <name>A0A433SUG5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AIG1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_019293</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000997">
        <property type="protein sequence ID" value="RUS72940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SUG5"/>
    <dbReference type="OrthoDB" id="6145359at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006703">
        <property type="entry name" value="G_AIG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045058">
        <property type="entry name" value="GIMA/IAN/Toc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903:SF184">
        <property type="entry name" value="GTP-BINDING PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903">
        <property type="entry name" value="GTPASE, IMAP FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04548">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51720">
        <property type="entry name" value="G_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="AIG1-type G" evidence="5">
        <location>
            <begin position="7"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS72940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="262" mass="28853" checksum="D6104868D37A1A47" modified="2019-05-08" version="1">MILVNMSEKFLIHLLGKTGTGKSSTGNTILGIKKFPCKSSTSAVTRVIQAEAGYLGPREVMVVDGPGLVDLNSGVNQSTMDAIKHLIEETKSNVQVFLMIWRYGDPFSPDDDAMLDAMRRTFGPSVFRNCGIILMTCGDNFRADTEDTDVTFNSWCKSQTGTFSKLLRECQGRVVLMENSRSITNRDQDALESLAAQIDSLDPKLATGESLLKDRLAIPTGVIKKCFFFALALLVIVLTWIFIDYAPSQEADARRAAHDVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SVP8</accession>
    <name>A0A433SVP8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_018912</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000950">
        <property type="protein sequence ID" value="RUS73319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SVP8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS73319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="249" mass="27399" checksum="6EB49B6E53F24EAE" modified="2019-05-08" version="1">MMQYGVPRKLYVFLGSGLRSEERCLSCCLWLKYGEPQVPSYLYVSGLELTRLSQRDGDGTLCFITGLPYRGKTRGARQGLYFYYDYANEFVKMASTSVFSFITFAIPIIMIIIISITEGSTVIIIINVIISSTIIIIIIIIIIIIIITIISISISISIIIIIIIIIIIIIIIRTAAAAAASSLLSSGATAGQAKDIIWNKNMAAISTELPEIKLETTGNQVSDTPYKEMHAPNAAPDHLIREKDGSCKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T1C8</accession>
    <name>A0A433T1C8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_016885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000748">
        <property type="protein sequence ID" value="RUS75363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T1C8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS75363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="105" mass="11839" checksum="BF2C6408A9F83FDC" modified="2019-05-08" version="1" fragment="single">ARGPPCLYPRHVALSATAWACGPVQVACFLSAYSSSLSSLFSFGLFPFALIFFTTFFLGFSFPCLPFSFGFHFLHFFLLPFRCKSSDPSASRYCNIFAMYIPWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T1G5</accession>
    <name>A0A433T1G5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytosol aminopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_016859</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000747">
        <property type="protein sequence ID" value="RUS75369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T1G5"/>
    <dbReference type="STRING" id="188477.A0A433T1G5"/>
    <dbReference type="OrthoDB" id="10041421at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963:SF48">
        <property type="entry name" value="DIPEPTIDASE B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="LEUCINE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytosol aminopeptidase" evidence="5">
        <location>
            <begin position="155"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS75369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="326" mass="34709" checksum="817500D9B0AEF721" modified="2019-05-08" version="1">MAAPRVEEYVREAFQGSPVQVSVVSDSDTLNKEYPLLGAVNRAADSVPRHKGRVIFLDYTGSGNITKTLFLVGKGITYDTGGADIKAGGVMAGMSRDKGGASAVAGFMKVLSILKPENLRVVGGLSMVRNSVGEESYVADEVITSRAGKRVRVGNTDAEGRMVMADVLCRMKEMAVDAVNPHLMTIATLTGHAVRAMGPAYSIIMDNGPARQRNTAQNIQSAGDKCGDPFEISTIRREDYEFHTDTSDYADVLQCNNQASTMTNRGHQGPSAFLILASGMDKHGIDSSQPLPYSHLDIAGSAGSYPDIPTAAPILALISHFVLDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T4W3</accession>
    <name>A0A433T4W3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_015684</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000653">
        <property type="protein sequence ID" value="RUS76552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T4W3"/>
    <dbReference type="OrthoDB" id="6198827at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS76552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="191" mass="21563" checksum="702234F6F22D18B1" modified="2019-05-08" version="1">MLPIRSLFIDKLFFITPPRSLRRVTPYPSPSLSIMGTMEELHDNYGKFYAQLLEFVGDFTNRLLPDAPRELQFVPVVADILPEDDPDFSTGDPDGVVQRALIIKQMTQLVLARARQFVQEGSYEWYDNHAGMLNIWLSLVSLSLATFQLADQENTEYLDTGIGAICTGFKSYRAIDVDKLRALQDVLIASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T763</accession>
    <name>A0A433T763_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_014958</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000592">
        <property type="protein sequence ID" value="RUS77294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T763"/>
    <dbReference type="OrthoDB" id="6154273at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="506"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="534"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="1"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="196"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="203"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS77294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="642" mass="69856" checksum="9621EBD3382BC25B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T7K5</accession>
    <name>A0A433T7K5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_014722</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000575">
        <property type="protein sequence ID" value="RUS77510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T7K5"/>
    <dbReference type="STRING" id="188477.A0A433T7K5"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12325">
        <property type="entry name" value="RRM1_hnRNPA_hnRNPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000030">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein d0 isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033">
        <property type="entry name" value="RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033:SF10">
        <property type="entry name" value="RNA-BINDING PROTEIN SQUID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="49"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="131"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="213"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS77510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="313" mass="34503" checksum="0D8FD66A7E039E62" modified="2019-05-08" version="1">MADEEQMQQEEPTEQYNEENGATEQVTEEQTENENQTAAADDDDDEDDRKIFVGGLSWETTTKDLREYFEKYGEVTNCNLKTDYESKKSRGFGFVTFASTDAVQKALAEKEHKLHGRTIDPKIANPRQVNKKVFVGRLDPSITEDEVKAYFEAFGPVEKLDLPFDKTKEQRRAFCFVEFKKVAAMKACLEKTSHKIGTHEVEVKKATPPGGAATRGGTRGRGGFGPQGNYGYGQGGYGYGYGQGGYGGYDQYGYGGYGGYDQYGYGGGYGQWNNGGGYDQNYGYGGGAYGGQSNYGKAQKRGAAHGGYHPYNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TC83</accession>
    <name>A0A433TC83_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_013007</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000463">
        <property type="protein sequence ID" value="RUS79222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TC83"/>
    <dbReference type="STRING" id="188477.A0A433TC83"/>
    <dbReference type="OrthoDB" id="342730at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19813">
        <property type="entry name" value="Bbox1_BRAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14959">
        <property type="entry name" value="NHL_brat_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="359"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="39"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="11">
        <location>
            <begin position="123"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="11">
        <location>
            <begin position="184"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="7">
        <location>
            <begin position="548"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS79222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="817" mass="90144" checksum="44D060385B4D3ADD" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TEV8</accession>
    <name>A0A433TEV8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">b(0,+)-type amino acid transporter 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Glycoprotein-associated amino acid transporter b0,+AT1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Solute carrier family 7 member 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">EGW08_012138</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">EC2010</strain>
            <tissue evidence="20">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-phenylalanine(out) + L-arginine(in) = L-phenylalanine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71067"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:71068"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-cysteine(out) + L-arginine(in) = L-cysteine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71071"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:71072"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cystine(out) + L-arginine(in) = L-cystine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71075"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:35491"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:71076"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71063"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:71064"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-leucine(out) + L-arginine(in) = L-leucine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71059"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:71060"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-lysine(out) + L-arginine(in) = L-lysine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:70827"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:70828"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000411">
        <property type="protein sequence ID" value="RUS80092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TEV8"/>
    <dbReference type="STRING" id="188477.A0A433TEV8"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000015">
        <property type="entry name" value="B(0,+)-type amino acid transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF512">
        <property type="entry name" value="SOBREMESA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00079910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00093193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RUS80092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="515" mass="55898" checksum="27B26BF996F1B765" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433THA8</accession>
    <name>A0A433THA8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_011331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000366">
        <property type="protein sequence ID" value="RUS80919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433THA8"/>
    <dbReference type="STRING" id="188477.A0A433THA8"/>
    <dbReference type="OrthoDB" id="10022583at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS80919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="334" mass="37508" checksum="30F90E8220ADBB7D" modified="2019-05-08" version="1">MYHLIQPSHLTILYNHLIQPSYTIISSNHLIQPSYPTISFIHRIQPSHPTISSNHLIQPSHPTISSNHLVQPSHPTVSSTHLIQPSHPTLLSNHLIHQSLPTISSSHLIYPSHLSILSNHLIQPSHPSISSNHLIQPSHPTIVYNHFIQPSYTTILYNHLIQPSYTTISPNHLIQPSHPIISSNHFIQPSHPTIASKHHIHPSHSSIASNHLIHSSYQTIKSDHLIQPSHPTISSNHLIHPPHPTISSNHLIQPSHQTILSIHFIHFIQPFYPTIPSKHLIQPSHPPISSTHLIHPSHPTIASNHRIQTTSSNNSSNYLIHTSHPCISSNHLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433THB1</accession>
    <name>A0A433THB1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_011280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000363">
        <property type="protein sequence ID" value="RUS80960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433THB1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS80960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="104" mass="11745" checksum="81CE2AE75428C863" modified="2019-05-08" version="1" fragment="single">RYMPITPESFTENWVVRLLSNLTGAAGMKSTEIPTDHLHHSLPWGSHISDPVKSIWVSKEVCEHLQQRAPLQDERGQHHLCQVHPYPHLGQQVTNDAAMLLHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433THT8</accession>
    <name>A0A433THT8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_011086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000353">
        <property type="protein sequence ID" value="RUS81145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433THT8"/>
    <dbReference type="OrthoDB" id="6161154at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="368"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS81145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="496" mass="53406" checksum="9138ABEAE9ACFF98" modified="2019-05-08" version="1" fragment="single">ANQEVGQPEQADAQLSQPPEAEVGTAADSDPKVENGGEVGSAEMSENVGVNTANDENVTSSQAHEEEGNSTTAPEEAETIKSTEDTDQQGEEQQQQQHEQQQPPEKAGDSGDVTDAHAPSVEPSEGEIPSTPAPPASRQSEYEEDFSETSNLASSRNTPAESKPEEGLSTEKEADEKAKDKDDKKSISSSSSSSSSAASTPEPKHDKKTTSPLPAESTGGGPEPSQSSGPPATDGEDKPAPLPPTGSGEEDQPQEEKEGEGTVPEAHEEGEERVDSRAEAAQVIPIPPPEPETKKADVDGRSSGAGGEEMADAEVFRGEDRTEMIAPEGSEDCRGQGQWKSAEQQAISAAMLVSKSERELTEEAVRERDTLRHDHDALKSQLLALEAEVDRKNEQLLVDREILARKDKEIADLQSELDNSNSAAASNEADQSRVKDLQERLAILARENEDKDKRFFKLEAELKETQTRLRETERRLIHAESHAVAEPPKSKTCVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TJD9</accession>
    <name>A0A433TJD9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase/retrotransposon-derived protein RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_010562</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000324">
        <property type="protein sequence ID" value="RUS81700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TJD9"/>
    <dbReference type="STRING" id="188477.A0A433TJD9"/>
    <dbReference type="OrthoDB" id="6117674at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006259">
        <property type="term" value="P:DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38681:SF1">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38681">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS81700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="385" mass="43654" checksum="A76991778925CD34" modified="2019-05-08" version="1">MLSHPMTEAEISISSDASDKVVGAVPEQYVNGSWQPLAFFSKQLRPSETKYSTFDRELLGLYLAIRHFRFYLEGRHFASTSHWHFRFYLEGRHFASYTDHKPLVGAMSKLSDPWSARQQRQLFYISEFSTDIRHISGKTNVVADCLSRTITDAEKLGTNIHHTCAYHPQSKNGLVERFHRSLKAALKARLQGANWVDELPWVLLGLRTVPKEDLETSSAELVYGEPLTVPGEFFHKDAHQSPVPNINFQTILQKIAPPPVLHHGYLPPNLSPTLKDSHFVFIRRDCHRGPLQRPYDGPFRVITPGDKTFLVMVGGREELISVDRLKPAHVDLANPVPVALPPRRGRPPQVTLMQQTTTSPPTPVEFEPQSTRYSDTGIRGPYDHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TJL8</accession>
    <name>A0A433TJL8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">KASH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_010508</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000322">
        <property type="protein sequence ID" value="RUS81754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TJL8"/>
    <dbReference type="STRING" id="188477.A0A433TJL8"/>
    <dbReference type="OrthoDB" id="18740at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034993">
        <property type="term" value="C:meiotic nuclear membrane microtubule tethering complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052403">
        <property type="entry name" value="LINC-complex_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47535">
        <property type="entry name" value="MUSCLE-SPECIFIC PROTEIN 300 KDA, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47535:SF1">
        <property type="entry name" value="NESPRIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1191"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="92"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="607"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS81754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1244" mass="140429" checksum="53C52C8D3F644E82" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TKJ9</accession>
    <name>A0A433TKJ9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_010155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000304">
        <property type="protein sequence ID" value="RUS82078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TKJ9"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS82078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="116" mass="14527" checksum="5DF6F462FC53E24F" modified="2019-05-08" version="1">MGEERRERERERERERERERERETERERERERERQRERTRKVHHTIAKQCKYLTFHSELFLIEGKFHLKPSSKYIDSIKHSKCKTNYAYHKEPKENVRLNAMTKILCVNVNFSEHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TL36</accession>
    <name>A0A433TL36_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_009975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000294">
        <property type="protein sequence ID" value="RUS82264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TL36"/>
    <dbReference type="STRING" id="188477.A0A433TL36"/>
    <dbReference type="OrthoDB" id="10065854at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS82264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="107" mass="12183" checksum="7CDC41ACC8A84CBD" modified="2019-05-08" version="1" fragment="single">MQSYLAQIKQNFHELQSQWDEVKSVAATALPHMQILKAGDVVVPRQALQDLAAEADQVKMLLPRVVNSNLLSAKAKLTKLETDLERTKKERDDFKTEVVHWKTQAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TLR6</accession>
    <name>A0A433TLR6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_009705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000282">
        <property type="protein sequence ID" value="RUS82533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TLR6"/>
    <dbReference type="STRING" id="188477.A0A433TLR6"/>
    <dbReference type="OrthoDB" id="6242194at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019204359" description="Endonuclease/exonuclease/phosphatase domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS82533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="33746" checksum="8553CA7D728A4D47" modified="2019-05-08" version="1">MIAKKMLQGIAFIFAAMVLGCNDAAMFEFRLIEENHNCTYFRELCQNLGYDGLAILSTPEAYQYAMDISANVRDTLGMHIFIGARYFPEYDATLWDDGTETRSDSPFGRHPPKADPNEPCTRLLHTGNFRLTADNLLYYGMCGNQLMTCTGESLRDAGVPTTLLTAKTKTRIGTWNIRTLYEIGRIAQGRRVTIIECDAPINVSAIEEKIRLYGHVQTVIDKVPRRDIRILFGDLNSKVGTDNTDMEHVMGIHGTENGYFFTEICLFNDLVIGGDNANSFGQEDQETQGVDLNRHIDTHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TMH7</accession>
    <name>A0A433TMH7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="2">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_009447</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000271">
        <property type="protein sequence ID" value="RUS82783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TMH7"/>
    <dbReference type="STRING" id="188477.A0A433TMH7"/>
    <dbReference type="OrthoDB" id="1915887at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06822">
        <property type="entry name" value="PLPDE_III_YBL036c_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000007">
        <property type="entry name" value="Pyridoxal phosphate homeostasis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00044">
        <property type="entry name" value="YggS family pyridoxal phosphate-dependent enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PROLINE SYNTHETASE CO-TRANSCRIBED BACTERIAL HOMOLOG PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146:SF14">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE HOMEOSTASIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01211">
        <property type="entry name" value="UPF0001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine racemase N-terminal" evidence="5">
        <location>
            <begin position="41"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="260"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="266"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="282"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS82783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="294" mass="32451" checksum="005B7E7067BE67A9" modified="2019-05-08" version="1">MLRRMSTEAPSIALKLKVVLGKIQVASEKRPEALQYATPLLVAVSKTKGLDMVMEAYDAGQRHFGENYVQELDEKGHDIELLDHCEDIKWHFIGRLQRNKVAKLLGVPNLYMIETVDNERLAKAVNDTWGKLNKPGPIKCMAQVNSSGEESKSGCTPDSAVELVRYIKENCPHLDLAGLMTIGSYDHDPKSGINPDFETLVKVREDVCKALSIPTEKLDLSMGMSGDYEQAIEMGSTIVRIGSTIFGSRNTVPSQATLEEAAEQAKGQDKDLDKSTQEEAVKSQTSQLKKLSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TMZ1</accession>
    <name>A0A433TMZ1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GP-PDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_009290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000264">
        <property type="protein sequence ID" value="RUS82953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TMZ1"/>
    <dbReference type="STRING" id="188477.A0A433TMZ1"/>
    <dbReference type="OrthoDB" id="1058301at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047389">
        <property type="term" value="F:glycerophosphocholine phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000032">
        <property type="entry name" value="Glycerophosphoryl diester phosphodiesterase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057506">
        <property type="entry name" value="C2_GPCPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051578">
        <property type="entry name" value="GDPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE PHOSPHODIESTERASE GPCPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25329">
        <property type="entry name" value="C2_GDE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM20" evidence="2">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="3">
        <location>
            <begin position="345"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS82953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="677" mass="76052" checksum="68339B8ED19B955B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TMZ4</accession>
    <name>A0A433TMZ4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_009304</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000265">
        <property type="protein sequence ID" value="RUS82920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TMZ4"/>
    <dbReference type="STRING" id="188477.A0A433TMZ4"/>
    <dbReference type="OrthoDB" id="752362at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="7"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="85"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS82920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="230" mass="25975" checksum="FC8ECEE239C80C9D" modified="2019-05-08" version="1" fragment="single">MHLKAMEKVFIGNLSADTNEDSLRKLLDQHAISFNNIVMKRNFAFVTVHDKISVEEIVKKLNGLTLNGSVLQAEPSNGRRSRKSTKIQIKNLSPNIMKDQVEELVNAISRSPKKFEQALSDGLVYVTFNTPEEAEECVEQLNDYRFDDGSRITVEFFRSQRRSNRSNSNSNSGTARQDLPLRMVVASDYVGAIIGKQGQTIRKITSESRARVDIHRRESHVPDTLVTIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TNF5</accession>
    <name>A0A433TNF5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_009166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000259">
        <property type="protein sequence ID" value="RUS83080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TNF5"/>
    <dbReference type="OrthoDB" id="6145939at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="746"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="845"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="798"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="874"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="893"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS83080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="968" mass="106407" checksum="499C1B265F13690B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TNW5</accession>
    <name>A0A433TNW5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_008953</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000250">
        <property type="protein sequence ID" value="RUS83273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TNW5"/>
    <dbReference type="OrthoDB" id="10564195at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS83273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="353" mass="39982" checksum="C3867E8557B4D644" modified="2019-05-08" version="1">MYFNTVGRMNTSEEVFLEIANLDVIFLTGQRDEFRSCLIESWSHATYCATHTCATPYAELLSVYGVRVTLWLSADIKGKTMSFYPISHIPRDWFYEDNVKEMDMHCDDCRFSFDKQRMVIVDEYTNDIGVLQVNWGIKPTEFLYVLGHRPTPHEMPLNSSDETVASAKYLSIEYLLEVTQVLNVSVFSNCRMELSSTVKPILTTDKEDPKQMTTEKSITTPMSSTQMESGETTTVGTTTTTEDSNSNVITTTCVSVLPNGTATKSSFLVNIITDNTYTQEVIESIYTHLVIPKTLLGSYRRRLSSAPDRRDSSRALGAFACISISFIIGVVFLLDMSSWQRRWPTLKRNLCHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TPF7</accession>
    <name>A0A433TPF7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secondary thiamine-phosphate synthase enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_008831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000244">
        <property type="protein sequence ID" value="RUS83410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TPF7"/>
    <dbReference type="STRING" id="188477.A0A433TPF7"/>
    <dbReference type="OrthoDB" id="10255963at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="entry name" value="YjbQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047_YjbQ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YJBQ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615:SF8">
        <property type="entry name" value="UPF0047 PROTEIN C4A8.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="YjbQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01314">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS83410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="17518" checksum="56D4B794FE4D2DA5" modified="2019-05-08" version="1">MASGGEGVTVWYQREVPLKSRSRGCHYITDEIDKACAEELNKIKVGVANIHIMFFINDNDPGYNFMVNIFLFFFRKDMEMVLNKVVPESWNYKHSLEGPDDMPAHAKAAMMGSSLSIPITNGKFNLGTWQGVWLCEHRDSGGSRKLIVTMNGLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TPX1</accession>
    <name>A0A433TPX1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_008677</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000239">
        <property type="protein sequence ID" value="RUS83571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TPX1"/>
    <dbReference type="OrthoDB" id="6153993at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS83571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="106" mass="12265" checksum="688E1EFDC1EEBCEE" modified="2019-05-08" version="1" fragment="single">NRTKDVSGATVIWLKVKEFQYRQAEKNKTFISYDYSSDYKMVDVRGVRRRSATSVPVPNIQPAYNQQLSISTLKNQDLLQICLQMVIHEELHGWFQSLPTTNGTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TQK1</accession>
    <name>A0A433TQK1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_008423</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000229">
        <property type="protein sequence ID" value="RUS83811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TQK1"/>
    <dbReference type="STRING" id="188477.A0A433TQK1"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000532">
        <property type="entry name" value="SLC (SoLute Carrier) homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF399">
        <property type="entry name" value="FI19708P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS83811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="456" mass="49755" checksum="8436E5DD0F552043" modified="2019-05-08" version="1">MGEVEKAPMFFSQRLLLAFMAFLGKVFIYMTRVNLSVAVVCMVRESVNNSTESLVYNSSSGLYYTTPASADSGSCGESSSSNKESFESVLLNIPLTFYFPQNAEFDWSKTTTGELLAMYFYGYIFTQIPGPLVGNVLTFAISGLLCAYGFDNGWGSIFYLAGIGNLLWVVAWFWLVADSPDQHPHISERERTYITTSIGKGAVKKVRRVPWLSMATSGPLWAVITSHMANNYLNYTLITSLPTFMKESLNFDVKENGALSALPYVCQFLGAIIVGQIADKVREKQLMSTKNVRKLFQTICKYIQSLGGAGICVAIVGQMGCEHRYAAVGMLCLCTILLSANRAGYLSNHLDLAPSYAGILYGITNTVATVPGMVAPIVTGALTPTGSADEWRTVFYVCAAIAIGGMIIFLLLADGELQNWAVPEDADFEVKVSSKADEETVMEGKPVSVLDHKTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TTE2</accession>
    <name>A0A433TTE2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_007375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000191">
        <property type="protein sequence ID" value="RUS84834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TTE2"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS84834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="93" mass="9770" checksum="6BFED4A70CF297B5" modified="2019-05-08" version="1">MEVNIGVVEVNVGALEVDIGAVKLNIEHWCCGMNIGAVEVNIGAVEVNIGAMEVNIGAVEVNIGAVEVNIGAVEVNIEHWCCGSEHWCCGSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TTU9</accession>
    <name>A0A433TTU9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">tRNA-dihydrouridine(47) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="19">1.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">tRNA-dihydrouridine synthase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">EGW08_007233</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">EC2010</strain>
            <tissue evidence="22">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the synthesis of dihydrouridine, a modified base, in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs). Mainly modifies the uridine in position 47 (U47) in the D-loop of most cytoplasmic tRNAs. Also able to mediate the formation of dihydrouridine in some mRNAs, thereby regulating their translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>5,6-dihydrouridine(47) in tRNA + NAD(+) = uridine(47) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53364"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:53366"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>5,6-dihydrouridine(47) in tRNA + NADP(+) = uridine(47) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53360"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:53362"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the dus family. Dus3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="19"/>
    <dbReference type="EMBL" id="RQTK01000186">
        <property type="protein sequence ID" value="RUS84988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TTU9"/>
    <dbReference type="STRING" id="188477.A0A433TTU9"/>
    <dbReference type="OrthoDB" id="259935at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106414">
        <property type="term" value="F:mRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102265">
        <property type="term" value="F:tRNA-dihydrouridine47 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000067">
        <property type="entry name" value="tRNA-dihydrouridine(47) synthase [NAD(P)(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25585">
        <property type="entry name" value="zf-CCCH_DUS3L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 19" id="KW-0288">FMN</keyword>
    <keyword evidence="6 18 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 19" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="9 18 19" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 18 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="21">
        <location>
            <begin position="133"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="18">
        <location>
            <begin position="133"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="83"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="283"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU291113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="RUS84988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="697" mass="78187" checksum="DDD1D4F21CBD9D99" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TU57</accession>
    <name>A0A433TU57_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_007145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000182">
        <property type="protein sequence ID" value="RUS85093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TU57"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS85093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="108" mass="12339" checksum="B17B285EF82C2650" modified="2019-05-08" version="1" fragment="single">ARPEEVGSHEKTRVKLVQFVVDKDAKCLESFRGHMCLAVHFVVTERSTTRQKQKHDGDHFCQLLCSCKVTKSIASIHNSMGYLACHLLLTILFQNVSQICRIQVVHYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TV73</accession>
    <name>A0A433TV73_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipid scramblase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_006796</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phospholipid scramblase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000169">
        <property type="protein sequence ID" value="RUS85463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TV73"/>
    <dbReference type="OrthoDB" id="191150at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017128">
        <property type="term" value="F:phospholipid scramblase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005552">
        <property type="entry name" value="Scramblase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248:SF63">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03803">
        <property type="entry name" value="Scramblase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="167"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="172"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS85463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="374" mass="41269" checksum="4C0BA6D029AB9FC1" modified="2019-05-08" version="1">MVAHPMQPGYGQPHQAGQPGFGAPLPGIQPGYGHPQTMQPGLGHPQMMQAAFGHPQTMQPGLGAPPPYSQQGAGGAGGPGFGAPGGPLNIPQGIVGPPPEVWMPVVQSIPDCPKGLEYLTKLDQVLVKQKTHMLEVFTDWECANKYKILNNQGQQCYYAFESNFSNDNGMEHDDDDDYDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDVDNTVFSLKRPFKCFGGCNWCAALRCAQDEVSVYTANGEQLGYVRQACSAWKPHYTILDAKKDPKFEIWGPCCPCTFCNANVDFPIRPIGSEEVIANISKQWSGFAREYFTDSDNFGVSFPMDLDVKLKATLIGAVFLIDFMYFEDTNKGNRGLMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TWC4</accession>
    <name>A0A433TWC4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_006375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000157">
        <property type="protein sequence ID" value="RUS85891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TWC4"/>
    <dbReference type="OrthoDB" id="6210247at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS85891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="406" mass="44398" checksum="82F31E783D6913CD" modified="2019-05-08" version="1">MKSGKEFRARTNSSTTTNSTASSELSKTDPEEKSTSSDDIDSETYHTLDEMSDNFGQETSTDECDDQGYNIIQDCQTKQFRSCEIRGGRRCRPLPQPPSSDKNLVQSVASALEGKSAGSSPVTPYSLAQSPVTWESTGYPPGITGLRELSDGLILPSLDASKSDIFPSLDTSGSNTIPPSYTSKCNSFPPKPRPHRRLVDLEEHQYLGLVYLRPNEAAFSHDGVSEVKLVRTRQGNLVLVSVQEGSLAFPECYTRIYLIDQAEGSLGVVGVLDLDLEETPSNESPALNLSYTDSASDPQSQTCTAELKSLSVNDDSLTQDATSTPNKFALDKYIYISYFGSVCLDEGVNLEPCDYLTALDIDINDVSAESGGYLTVRDVGGIYTDRFERPNSNSEPNNYLELIHEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TYW3</accession>
    <name>A0A433TYW3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP synthase subunit beta</fullName>
            <ecNumber evidence="12">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_005486</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="12"/>
    <dbReference type="EMBL" id="RQTK01000129">
        <property type="protein sequence ID" value="RUS86763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TYW3"/>
    <dbReference type="STRING" id="188477.A0A433TYW3"/>
    <dbReference type="OrthoDB" id="14523at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18110">
        <property type="entry name" value="ATP-synt_F1_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18115">
        <property type="entry name" value="ATP-synt_F1_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01133">
        <property type="entry name" value="F1-ATPase_beta_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000001">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.170:FF:000004">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000026">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050053">
        <property type="entry name" value="ATPase_alpha/beta_chains"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184">
        <property type="entry name" value="ATP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184:SF71">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039072">
        <property type="entry name" value="ATPase_subunit_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="193"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS86763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="523" mass="56361" checksum="445A75D2E6F2AA0A" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TYY9</accession>
    <name>A0A433TYY9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tyrosine-protein kinase ephrin type A/B receptor-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_005495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000129">
        <property type="protein sequence ID" value="RUS86772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TYY9"/>
    <dbReference type="STRING" id="188477.A0A433TYY9"/>
    <dbReference type="OrthoDB" id="413581at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46967">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN,N-TERMINAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46967:SF1">
        <property type="entry name" value="KERATIN-ASSOCIATED PROTEIN 16-1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein kinase ephrin type A/B receptor-like" evidence="1">
        <location>
            <begin position="130"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein kinase ephrin type A/B receptor-like" evidence="1">
        <location>
            <begin position="215"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS86772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="246" mass="26068" checksum="C3E5362F24FE0783" modified="2019-05-08" version="1" fragment="single">MKVFTVLEINCSLHKARSSRAIHLDLTKCLSWYFILSSIVVCALANVSEYSQIELDDLNCTGTHLDNCAACEAGTYANEELKLCGCCTNGKGVCRETADCVPCIAGYAQPNPGQSVCNKCTIGFSTEGKQRSSKCIPCSAGYYAGTDGSAECSPCPEGTATDKEAQFACPACQEGHYTNKTGQTACEPCPPGNFCAVQKCTECKLCPKGSYTNSTGTVVCHPCWLASYQPEKGQTTCLECPAGSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U215</accession>
    <name>A0A433U215_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COX assembly mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_004367</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CMC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000098">
        <property type="protein sequence ID" value="RUS87889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U215"/>
    <dbReference type="STRING" id="188477.A0A433U215"/>
    <dbReference type="OrthoDB" id="6224010at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013892">
        <property type="entry name" value="Cyt_c_biogenesis_Cmc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08583">
        <property type="entry name" value="Cmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS87889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="130" mass="14293" checksum="A769B65C4F452F31" modified="2019-05-08" version="1">MATTLGNGNEGDDCVLSKSLGGGPLGLGDPDDRSLRKAEKEILIPAKMKEKAKRLKCASEVKDFGECAKQQGLMMPFMCRPKAKSLENCLKAAYSDPAFIALCTEEFLEERAHFRRTGVKAKERKKDAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U354</accession>
    <name>A0A433U354_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_003999</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000089">
        <property type="protein sequence ID" value="RUS88233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U354"/>
    <dbReference type="STRING" id="188477.A0A433U354"/>
    <dbReference type="OrthoDB" id="6053211at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000002">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="12">
        <location>
            <begin position="48"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="13">
        <location>
            <begin position="247"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS88233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="452" mass="49983" checksum="42E5C36FCB022FED" modified="2019-05-08" version="1" fragment="single">REVLSIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAIFVDLEPNVVDEVRTGTYRQLFHPEQLCTGKEDAANNYARGHYTVGKEMIDLVLDRVRKMADSCTGLQGFLIFHSFGGGTGSGFSSLLLERLSVDYGKKAKLEFAIYPAPQVSTAVVEPYNSILTTHTSLEHSDVAFMVDNEAIYDICRRNMDIDRPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLTVADITNACFDAANQMVKCDPRHGKYMACCMLYRGDVVPKDVNAAIAALKTKRNIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGVDSCDASGEGEDDAEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U4B7</accession>
    <name>A0A433U4B7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_003615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000077">
        <property type="protein sequence ID" value="RUS88656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U4B7"/>
    <dbReference type="OrthoDB" id="6158874at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS88656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="323" mass="35689" checksum="983A27937FFC5B8C" modified="2019-05-08" version="1" fragment="single">MSLSLDTSELEGDVEDFEGDTDLNEWAAMGEDGPDILVSKLPQQSQYQALSRENRNLQKNIAALADQSLSKSHGAKQGKSFDEGSSNTNSLVSPRSPRPAPRTAGSAKPEILKVGKPQETATPLKRKASSDPDMLDEGEEAKTRKMESDILMAIEDPGSKSMSQSEVEDKDQDEHTRRMSFSPEELRSLDSLLVSEMMGGVKKQMFLRMAKGDRYVVTFAPVELADLAQVSVQKIIESQPNLAFFFNRQGKFKKKKGYAQAYFSLTSEVRSFINRLMYVTLSEKSTEISVSAIMNSGKHNVQVSFVLSSSNKDRLLGLLDSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U4S9</accession>
    <name>A0A433U4S9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_003443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000073">
        <property type="protein sequence ID" value="RUS88813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U4S9"/>
    <dbReference type="OrthoDB" id="10552774at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019215771" evidence="1">
        <location>
            <begin position="22"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS88813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="141" mass="15696" checksum="E9387F50FD8A96A0" modified="2019-05-08" version="1">MKTSLICLFLLLAWTIAASWAEDEDGDGDGCAHGCQVSCVFPSDTCKHMSRRFQKPCLEDLEFCVLTCTKRCECARQCKERTIQEGRVEGGFDACVDECFEASMKGVHPPQSKREKKVTESDVMPMLHPGMLLSGEMGHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U7C2</accession>
    <name>A0A433U7C2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_002530</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000049">
        <property type="protein sequence ID" value="RUS89712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U7C2"/>
    <dbReference type="STRING" id="188477.A0A433U7C2"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15898">
        <property type="entry name" value="BIFUNCTIONAL APOPTOSIS REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15898:SF13">
        <property type="entry name" value="BIFUNCTIONAL APOPTOSIS REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="45"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="7">
        <location>
            <begin position="185"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS89712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="444" mass="51337" checksum="AEB49B2FEB0ED7AC" modified="2019-05-08" version="1">MEADQPDDTLEITESVTDSQEHNGSSLIKRKSLDVKSDLEDDLACSVCLMLAVQPTTLVCGHTSCRMCLAQWYFTSKTKTCPMCRQPYQGLPRVNIQIRKMTRKLYPEKARQREEELEGDEEAKRAVAKYDKELSEEGSSSGDTDMASFCAGILIAICTFVVIYLAWYWQSSDSNLLVLKPVQTWKPKDVSQWVEELTWAHTYTVPVLEKKVDGNMLLSLTKNDLQPLLNMTDPVHQNAFVFAIDLLREDGVKMPANLWEYKAIYPGRSLFIAFSMKDFPRSSLLYMYVYFYDDMFLPFVRASTFSDTDKPQQKHAQAEDITFSQWIAFFVYGLLVPEWLVIAFALQMFSHHFFTPLFVIATGVLYQILEYLSWISLFRNFTPRSLYDLMKSHLKQLTSAFMFMVLWPIIPRVICDMFFYTALYISPVQASLAIYNKFLALNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U7I7</accession>
    <name>A0A433U7I7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA2 rift barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_002498</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000048">
        <property type="protein sequence ID" value="RUS89795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U7I7"/>
    <dbReference type="STRING" id="188477.A0A433U7I7"/>
    <dbReference type="OrthoDB" id="306218at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048459">
        <property type="entry name" value="DNA2_Rift"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21123">
        <property type="entry name" value="Dna2_Rift"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2 rift barrel" evidence="2">
        <location>
            <begin position="109"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS89795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="238" mass="26372" checksum="8810F1F2EAF8E126" modified="2019-05-08" version="1" fragment="single">MAKELSRQVTFETNDSGSKSAKLGRLPEPINNEQACRKCAHLLTCSIYQRSEKTELRADHAMSSLVPEALAHLGDTDLTYFLHWVLCLDVERQESEHKQLQQIWGSSSRQRESEGECISNLIITGSELGVPESQSFNDGQGCSLTFSRHSSYPGSALNTVGLTAGDMVVLSSEDGRLIALATGFVRNISSSLVEIVVDRDYLHNTASYRDVKFRLDRNSSFSTAGYLYTNLARLMDPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UDB3</accession>
    <name>A0A433UDB3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_000460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000006">
        <property type="protein sequence ID" value="RUS91752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UDB3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS91752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="109" mass="12565" checksum="30707B461B3B5B7F" modified="2019-05-08" version="1">MVSKTGESFRAFCECLNDRISYRNMNKAKSLSRHISTCVYSNPVQKRSAYGTCYKRASSPFHSVCREASRSKGTTGDLRNTRRSNCDCEMNLVLLNGHQFELQYSRQYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZAS4</accession>
    <name>A0A3S0ZAS4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_017568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000810">
        <property type="protein sequence ID" value="RUS74662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZAS4"/>
    <dbReference type="OrthoDB" id="6150302at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS74662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="27101" checksum="B698775706639B6F" modified="2019-04-10" version="1">MDKNRAIILGILGALVVVGGVAMSVVIFFMLDVLQEGYIENSSQGDENFKKFKDNSQSPMWALGFAFIIPGVFLFVAALIQNKAGYIISAILSLLTLLLMGIFVLAASLFLFIFIVSIGAIDDHCKDTSDGCICHVEDDNHSSSSEDVILFRECHYFSSFASLMVALFICIIVSWILLLIAFILAIYFSCRSNTNQAGNVYAPVQQPVFTSSQYQSPPPSYAYEDQGKLTYLEGGSQSYYDGPPSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZCQ7</accession>
    <name>A0A3S0ZCQ7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_020284</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001136">
        <property type="protein sequence ID" value="RUS71956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZCQ7"/>
    <dbReference type="STRING" id="188477.A0A3S0ZCQ7"/>
    <dbReference type="OrthoDB" id="1421090at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365:SF541">
        <property type="entry name" value="PROTEIN TOLL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365">
        <property type="entry name" value="TOLL-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01582">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01537">
        <property type="entry name" value="INTRLKN1R1F"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="8">
        <location>
            <begin position="120"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="371"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="371"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS71956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="402" mass="45507" checksum="66FCF0E4FD18C83A" modified="2019-04-10" version="1">MENQKVGCECEDKFSDNMCDKPCLLECGESGKCRIQDDNGTEECFCSDHRYRGFNCSILIEELQPSGLGLEAKAAVGVVAVLMVCLMMLLVVLYALWRRRNITMMKIVYWFHSFEEDDDRDCDAFVSYASADLDRQFVIQVLAPMLEGQMCFSLCLHQRDFLPGQYISHNISESVKRSRRTIMVVSPAYVSSDWCRFEFQMALQEMVSQKHRILPILLDDVGSLKKDMDETLKKVLEAVTWIKYPGTEAKDKELDQFWKRISLSMPKKRPVSEEQGPIKAHPAHIVSPSLSPNTNLTSSTCKGFKDIDSSDIPEGSTHHYEIILHEGDKEDAIFRVSPPGKDSDGGFESSRKKRARTTLLPNFLGPLCGRSNSKSFSSSQSHTQTSESVLNKTGIPKNRRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZCT7</accession>
    <name>A0A3S0ZCT7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_017451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000800">
        <property type="protein sequence ID" value="RUS74784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZCT7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS74784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="108" mass="12654" checksum="B403729780EBA617" modified="2019-04-10" version="1">MDTGSGRRDQSTASLLNWSIDTFHALTDIPIVMLARAEDEMRDLSRSPNRRAVGKNREEVSTWRHVCQSGRCCWQTQESFWPGHDQRLPEISHHLAQCQDLWYRESRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZI59</accession>
    <name>A0A3S0ZI59_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_012784</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000450">
        <property type="protein sequence ID" value="RUS79443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZI59"/>
    <dbReference type="OrthoDB" id="7294180at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS79443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="136" mass="15667" checksum="26E51F98483F16EE" modified="2019-04-10" version="1">MRMVISDTGRTVIFYCKSRSRASNMDDKTLVAAVEKREALYDKGNNYNSNRIFMQKQWADVGLEVGEEGISFSLCLSLGVTKYFVQKVVAFSIYQPSKNTVHPISPSECLYLLKPIKHHHSQTCESNYYRLHLEHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZIQ3</accession>
    <name>A0A3S0ZIQ3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">small monomeric GTPase</fullName>
            <ecNumber evidence="3">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">EGW08_012385</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">EC2010</strain>
            <tissue evidence="20">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Golgi apparatus</location>
            <location evidence="13">Golgi stack membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 19">Belongs to the small GTPase superfamily. SAR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="3"/>
    <dbReference type="EMBL" id="RQTK01000424">
        <property type="protein sequence ID" value="RUS79859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZIQ3"/>
    <dbReference type="STRING" id="188477.A0A3S0ZIQ3"/>
    <dbReference type="OrthoDB" id="15478at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00879">
        <property type="entry name" value="Sar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000161">
        <property type="entry name" value="Small COPII coat GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006687">
        <property type="entry name" value="Small_GTPase_SAR1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45684">
        <property type="entry name" value="RE74312P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51422">
        <property type="entry name" value="SAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 19" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 19" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 19" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 19" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 19" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>GTP</name>
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        </ligand>
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        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
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        <ligand>
            <name>GTP</name>
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        </ligand>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
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        <location>
            <position position="51"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
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        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
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        <location>
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        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
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        <ligand>
            <name>GTP</name>
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            <name>GTP</name>
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            <name>GTP</name>
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            <name>GTP</name>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00037843"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-2"/>
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        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RUS79859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="193" mass="21875" checksum="5D7137377FC89B49" modified="2019-04-10" version="1">MFLYEWLSSMLNFLGLWKKSGKLVFLGLDNAGKTTLLHRLKDDRMAQPVPTLHPTSEELSMGGMRFTTFDLGGHRQARRVWKDYFPAVDAIVFLIDCHDRNRMVEAKAELDSLLADEQVASAPILILGNKIDLAGAASEDDIRHWFGLHNLTTGRGTASRSELPSRPMELFMCSVLKRQGYGEGFRWLSQYIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZJI9</accession>
    <name>A0A3S0ZJI9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_013044</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000465">
        <property type="protein sequence ID" value="RUS79186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZJI9"/>
    <dbReference type="STRING" id="188477.A0A3S0ZJI9"/>
    <dbReference type="OrthoDB" id="341482at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019321">
        <property type="entry name" value="Nucleoporin_Nup88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037700">
        <property type="entry name" value="NUP88/NUP82"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257">
        <property type="entry name" value="NUCLEOPORIN NUP84-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10168">
        <property type="entry name" value="Nup88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS79186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="125" mass="14430" checksum="2E0F77BECE632E4C" modified="2019-04-10" version="1" fragment="single">VLREKATAISEKLEKCKDDHESLCRRLEGCLRKVQSRIPVLSEAERQEMKELNAIKSSMDLYKQNIDQVRVKQEYQQRQIQRVGGGSSPALHKRQLAQIQTILQDEASDIQELKEDITRLNVTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZL12</accession>
    <name>A0A3S0ZL12_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Doublecortin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_022372</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001552">
        <property type="protein sequence ID" value="RUS69866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S0ZL12"/>
    <dbReference type="OrthoDB" id="9999986at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902412">
        <property type="term" value="P:regulation of mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17158">
        <property type="entry name" value="DCX3_DCDC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043188">
        <property type="entry name" value="DCDC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056415">
        <property type="entry name" value="DCX2_DCDC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003533">
        <property type="entry name" value="Doublecortin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036572">
        <property type="entry name" value="Doublecortin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057424">
        <property type="entry name" value="Ubiquitin_DCDC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46302">
        <property type="entry name" value="DOUBLECORTIN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46302:SF3">
        <property type="entry name" value="DOUBLECORTIN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24478">
        <property type="entry name" value="DCX2_DCDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25510">
        <property type="entry name" value="Ubiquitin_DCDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89837">
        <property type="entry name" value="Doublecortin (DC)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50309">
        <property type="entry name" value="DC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Doublecortin" evidence="3">
        <location>
            <begin position="198"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Doublecortin" evidence="3">
        <location>
            <begin position="989"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="794"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1091"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1592"/>
            <end position="1638"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="436"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1099"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1132"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1612"/>
            <end position="1630"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS69866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1760" mass="199808" checksum="FE78076FDC8670A3" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZND9</accession>
    <name>A0A3S0ZND9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Netrin module non-TIMP type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_009153</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000259">
        <property type="protein sequence ID" value="RUS83067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZND9"/>
    <dbReference type="OrthoDB" id="6160688at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018933">
        <property type="entry name" value="Netrin_module_non-TIMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01759">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="TIMP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="Netrin module non-TIMP type" evidence="3">
        <location>
            <begin position="50"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS83067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="348" mass="36695" checksum="8B2323E07CC6EEEB" modified="2019-04-10" version="1">MVLNFTTVSSGFGVGFVVVLGWFRRSQHSRQLFSEVANTSVHDKSLLYGRFAIRASIKKRKRNKRGELLYRVKVIQVLFSGKVKVETNKVATLLVVGGQCSCLKMRRGREYLILGHENRDSNRLMVSQLSINARCGVSGGGCGGGSDGVSGGGCGGGSDGGSGVGCGGGCGDGVSGGGCGNGCGVGCGDGKWQKRLEKRKRLNRRNRTDVLASRHRGRQSTKTTSGADGSALPGDQYGSYPSSTGISRDTDGDHQRGPSSSLSSSSSFPDSPYSSSSSSSSSSSSTSTKTNSISANAGGRRRDGHGSGYGSFNLDDLQNGYRHGGRYYSKELAQLHRYKLAALRELLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZY47</accession>
    <name>A0A3S0ZY47_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_002678</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000052">
        <property type="protein sequence ID" value="RUS89560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZY47"/>
    <dbReference type="OrthoDB" id="10028859at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018555711" description="F5/8 type C domain-containing protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="83"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS89560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="218" mass="24156" checksum="94B76CA849AC4B07" modified="2019-04-10" version="1">MDSGNMRGSLGALLLLLLVYAHVPTFCDGVPCPSLSPPLNGVLKCQRNNGKLQCMATCYQGHVFDTQEPVVLRNCDHVTGHWEEGDFLPVCSGGFADYHYPVVTASSGDDVINGLTLSQRATLESRDSWRPTQDNLAQYLQVEFNSTVRINGIIVRGDLSENYVTAFRVLFSQDGHKWYPYTDGQEAEKVRRREALKVFCLLDFKDGSYTAAGPKTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZYM4</accession>
    <name>A0A3S0ZYM4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">EGW08_002939</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">EC2010</strain>
            <tissue evidence="18">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000059">
        <property type="protein sequence ID" value="RUS89332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S0ZYM4"/>
    <dbReference type="OrthoDB" id="416585at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000063">
        <property type="entry name" value="Voltage-dependent N-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000023">
        <property type="entry name" value="Voltage-dependent R-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031649">
        <property type="entry name" value="GPHH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014873">
        <property type="entry name" value="VDCC_a1su_IQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF7">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08763">
        <property type="entry name" value="Ca_chan_IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16905">
        <property type="entry name" value="GPHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01062">
        <property type="entry name" value="Ca_chan_IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="158"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="493"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="535"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="706"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="821"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="926"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="831"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="872"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="972"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="992"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1024"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1052"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1148"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1193"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1216"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1287"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1303"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RUS89332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1313" mass="147077" checksum="6BC8884CC78563FF" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A0K8</accession>
    <name>A0A3S1A0K8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL14m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L14, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_012602</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000438">
        <property type="protein sequence ID" value="RUS79633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A0K8"/>
    <dbReference type="STRING" id="188477.A0A3S1A0K8"/>
    <dbReference type="OrthoDB" id="274765at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000018">
        <property type="entry name" value="Ribosomal protein L14, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21037">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L14, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21037:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS79633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="150" mass="16408" checksum="C47A2B867BE0546F" modified="2019-04-10" version="1">MALCMTSAPSQVVPSLIRIATTCCCFSTSKTHYEIRNLARMRIVDNSAIGKAAAEIGKPPRVINVYNRKNVGYLGDKVLVTVKGEMRRAYIVGLRQKQKANVPRMDTNNIVLVDDNGNPLGNRIHVPIPSCLRGKGGDITKILSLATKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A305</accession>
    <name>A0A3S1A305_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WIBG Mago-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_010850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pym family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000339">
        <property type="protein sequence ID" value="RUS81412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A305"/>
    <dbReference type="STRING" id="188477.A0A3S1A305"/>
    <dbReference type="OrthoDB" id="21625at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903259">
        <property type="term" value="P:exon-exon junction complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039333">
        <property type="entry name" value="PYM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015362">
        <property type="entry name" value="WIBG_mago-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036348">
        <property type="entry name" value="WIBG_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22959:SF0">
        <property type="entry name" value="PARTNER OF Y14 AND MAGO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22959">
        <property type="entry name" value="PYM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09282">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01273">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101931">
        <property type="entry name" value="Pym (Within the bgcn gene intron protein, WIBG), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WIBG Mago-binding" evidence="3">
        <location>
            <begin position="17"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS81412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="203" mass="23019" checksum="38C23476D3194C0B" modified="2019-04-10" version="1">MASALERSGVVRDEKTGELMLPATQRPDGTWRKPRRVKDGYIPQEEVPVYETKGTQWLKSIPDHPIGLSPADVTKMRAAKAGNAQEPEQTAASKSAKKNAKRKEKRKQQQVSGNKDIGSLADSVSQVKLSTEKQAAQDTENLSKEDIEKKLKKLRKKLRHTEELEEKIDKGEIKNPEKEQLEKVQNKQKLIEEIEDLELELED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A548</accession>
    <name>A0A3S1A548_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_001316</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000022">
        <property type="protein sequence ID" value="RUS90919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A548"/>
    <dbReference type="STRING" id="188477.A0A3S1A548"/>
    <dbReference type="OrthoDB" id="6114255at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="298"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS90919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1060" mass="120401" checksum="B120A8B0D204FF97" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A5M2</accession>
    <name>A0A3S1A5M2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acyl-CoA dehydrogenase/oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_008947</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000249">
        <property type="protein sequence ID" value="RUS83325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A5M2"/>
    <dbReference type="STRING" id="188477.A0A3S1A5M2"/>
    <dbReference type="OrthoDB" id="434771at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase fadE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF35">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY MEMBER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="8">
        <location>
            <begin position="108"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="7">
        <location>
            <begin position="210"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="343"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS83325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="39513" checksum="0F5599D57FA14817" modified="2019-04-10" version="1" fragment="single">NRSGNIVPGCNLNLPRHSLEPCNTAARQQEHCYSTFVSSSSRKIQPIMTSLNMRSTSSSSVLPEQAGMMAVSVEGLSPKVQDLHRRVKQFIEENVLHLEQIRTERLNRPGVNKWEVMPELEEAKAKAKAAGLWNLFLPLESDPGAKYGAGLTNLEYAFLCEEMGKCILAPEVFNCSAPDTGNMETILRYGTEEQKQTWLEPLLEGRIRSCFAMTEPKVASSDATNIESSIRREGDHYIINGHKWWTSGALDPRCKICVFMGKTDSGAAKHRQQSMVLVPMDTPGIRIVRPLTVFGYDDAPEGHGEVIFENVRVPVTNILLGEGRVGSRSPRGVLVRADPPLHASHRPRRARSAVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B0V1</accession>
    <name>A0A3S1B0V1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_015024</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000600">
        <property type="protein sequence ID" value="RUS77197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B0V1"/>
    <dbReference type="STRING" id="188477.A0A3S1B0V1"/>
    <dbReference type="OrthoDB" id="6153627at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF26">
        <property type="entry name" value="MFS-TYPE TRANSPORTER SLC18B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS77197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="172" mass="18120" checksum="F710C8622811C9E5" modified="2019-04-10" version="1" fragment="single">VFTIAPALYGLTAPLFGYISDSKGYVFSILILGNLGNGIAYLIIGPSPYLPFLPSKLWVVIIGTMLLGLSIGASVIPAIKCMLVGACDIGFENNLDTYGLVSGLFNSIWCLGGFVGPTIGGVLVNEMGFNKAASVIALSQFFSAIAALIFCIVRKVKQATKDQANLQVSYSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B1J3</accession>
    <name>A0A3S1B1J3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_018350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000890">
        <property type="protein sequence ID" value="RUS73880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B1J3"/>
    <dbReference type="STRING" id="188477.A0A3S1B1J3"/>
    <dbReference type="OrthoDB" id="10059790at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS73880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="24847" checksum="3C0554AE0E1727F4" modified="2019-04-10" version="1">MTQASESLREASLSTVLLTTKTKTRTGTWNIRTLYETGKIAQVSKEMKEYSLKILELCETRWTGADRRTLYVLLYGSETWRTTKTNTTKLQTFINGCLKYILKVRWPQTISNEELWRRTEQTPIDIQIKKRKWGWIGHTLRKPPTDIMRQSLEWNPQGKRKVGRPKQTWRRSMEAEIRSAGRTWTELKRDAQNRVRWRGVALALCSSGDPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B1M3</accession>
    <name>A0A3S1B1M3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_018313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000885">
        <property type="protein sequence ID" value="RUS73923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B1M3"/>
    <dbReference type="OrthoDB" id="7442607at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS73923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="213" mass="22085" checksum="D5EFD893C27A6BA2" modified="2019-04-10" version="1" fragment="single">MDAACPLSPRAKDFSITSLMTGPSGLDPMQEGADTTTPPTSTTTSATTSSTNNDNSINGDSSPNSRNSIININNNNNNITKDLASIEPASHRLESIAGFGVGAAGSLGGLVGSESLSSVLGHCIASGVQTSGQECVFNPWSHQVSHYNQLSSMQACVTGCGTGTGRRYQTLQYEHPLHQAGEHHLGTATGMAGHVGHQQHHSHDTNNTSSNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B3W6</accession>
    <name>A0A3S1B3W6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_017848</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000835">
        <property type="protein sequence ID" value="RUS74393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B3W6"/>
    <dbReference type="OrthoDB" id="6162071at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="560"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="575"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS74393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="598" mass="66868" checksum="5588B7007689BF1B" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B4D0</accession>
    <name>A0A3S1B4D0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_020578</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001179">
        <property type="protein sequence ID" value="RUS71654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B4D0"/>
    <dbReference type="OrthoDB" id="3137333at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS71654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="172" mass="18408" checksum="A27AED4A534AE1DA" modified="2019-04-10" version="1" fragment="single">MYANHPFTTPFSVKDILSWSEQQGALDYPGGGLGYMQGPPYSYDMSPTHQHRGGAPTSGYDQLSALPSNPACLYGSATPTYTNLSYPTHHAHPHSSAAVMVGGGGTMLKPSDYDVGVMSGLGGIKPDYETQVTADSMSLPVKQEYESHVTEMGSHVGHMGDQVCMEDECEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B4X3</accession>
    <name>A0A3S1B4X3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_016088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000684">
        <property type="protein sequence ID" value="RUS76145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B4X3"/>
    <dbReference type="OrthoDB" id="6136825at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS76145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="300" mass="33028" checksum="C164CB25D68091DD" modified="2019-04-10" version="1">MPVDPSVRLIRERDYEAIITCLDKELAEAKMPDNPLDYFVSLNFDADMLRSKSQVMCSNLTKHGEKLMWVECVCVPREPEPIISRCAREAASSLEVNPSQAQPSSVLDFFILGIRTDCISYEARFDCYRRELQNITNFRDFWLSLTFDHDNAVASQRKYCGQVQVTRATCLDQAMRPCGEDLARYMAVSEMGNLPDTCRSLLRPRSGDKGETGESEMLPGTIDQDRAGKERVPLGEINPHSVGQTTETKKTTGVGVTGGTSSGSKSDGSSDKNGASALSSLLSVLFIALYLIGVGLSVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B690</accession>
    <name>A0A3S1B690_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_019152</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000978">
        <property type="protein sequence ID" value="RUS73091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B690"/>
    <dbReference type="OrthoDB" id="6066489at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.990">
        <property type="entry name" value="Nemo cc2-lz domain - 1d5 darpin complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="235"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="312"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS73091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="381" mass="44042" checksum="DB5D1E7511386B03" modified="2019-04-10" version="1" fragment="single">MMSSVSQPTSMGLEDEQSSLEAERDKYRQGYSNMTVVVKELQQQLAQYKLRCAGVDTLAVVLKEAKQESVILARQKKALETAITNLQNRLSTNNLSASVNIEETDLYVPGTSKQTLDNIARENARLRSLLKNAEHQSGKKSIDDSQELKTLVEGLESDKNQLQAQLQEVEGIKLNMVRQYEETIAKLKKDMAEEKEKMRKDFDKYKNSDKDSSKGRSEDKKSVECQTLGMQLDLVDNLKRSLKNIAEQCKELDEDLDNLKITLMNQRWQIHSDAKERQHMANISEYKNNFLLVYSQEIEAWKQEADLNRAENVRLVQIVEDLQRTLNQLRQKPHIDPSMVEILKQQIQVCTEDFNNERKDHEQALNQKKQLQAEVEKLKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B9P7</accession>
    <name>A0A3S1B9P7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_016792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000742">
        <property type="protein sequence ID" value="RUS75442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B9P7"/>
    <dbReference type="STRING" id="188477.A0A3S1B9P7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS75442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="120" mass="12860" checksum="1001B8E937CC2734" modified="2019-04-10" version="1" fragment="single">ICTCINVRMSGICACINVRISGICTCINVRMSGICTCINVRMSGICACINVRMSGICTCINVRMSGICTCINVRMSGICACINVRMSGICTCINVRMSGICTCINVRMSEICTCINVQMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BAZ8</accession>
    <name>A0A3S1BAZ8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_015891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000669">
        <property type="protein sequence ID" value="RUS76361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BAZ8"/>
    <dbReference type="OrthoDB" id="7981150at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS76361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="130" mass="14044" checksum="9E99BF7B280B7A27" modified="2019-04-10" version="1" fragment="single">DTDPTRRERNSLDSNSGPFASEADVLALDPPPPPLAPPPLALDTHPLALDTHPLTLDTHPLALDTHPLALDTHPLALDTHPLTLDTHPLALDTHPELPIDLRRQGLHCVLDTHPLALDTHPLALDTHPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BBD1</accession>
    <name>A0A3S1BBD1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Legumain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_015599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000648">
        <property type="protein sequence ID" value="RUS76623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BBD1"/>
    <dbReference type="STRING" id="188477.A0A3S1BBD1"/>
    <dbReference type="OrthoDB" id="9973749at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000">
        <property type="entry name" value="HEMOGLOBINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000:SF42">
        <property type="entry name" value="LEGUMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018637363" description="Legumain" evidence="2">
        <location>
            <begin position="23"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS76623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="22668" checksum="FA8A1B7873DA3999" modified="2019-04-10" version="1">MMNAISFTGTLAFLALASLTYGAERKKWALLIAGSAGYGNYKHQADVCHAYQITHKNGIHDEQIVVMMYDDITNNDYNPVQVEQFLANGTTVYNNKKQDRRTYPGNGVPTDMAGLLSLKRLAASSHPRHVTKRTEIKTDFQAQMRLKDHTNQVMTDIAQRVYTSMDISWTLNSRSETGTATNAQWTDCLSFAPALLQTPTITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BC29</accession>
    <name>A0A3S1BC29_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_007509</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000195">
        <property type="protein sequence ID" value="RUS84722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BC29"/>
    <dbReference type="OrthoDB" id="10470229at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015347">
        <property type="term" value="F:sodium-independent organic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043252">
        <property type="term" value="P:sodium-independent organic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388">
        <property type="entry name" value="ORGANIC ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388:SF157">
        <property type="entry name" value="SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 2A1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS84722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="189" mass="20970" checksum="E88F9C555771EA0E" modified="2019-04-10" version="1">MNGHSMERRGKEEVAMVPKAGWGEKTGVWDDGEGSGDEEGCGVGSCRPGFLKRFSHIALFSMLMGCASMFVDVLLSYLGTQFIWLERLYGLTPAQTKMLLIWGKIGFLALVPFLSVMARRWHMPRTLSITAFVVAIAAIICLMPYPIHKADLHAPPNVTKETQFTISRLLIQLPSVHLILSCLISSYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BCL0</accession>
    <name>A0A3S1BCL0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonuclease H</fullName>
            <ecNumber evidence="3">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_014718</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="3"/>
    <dbReference type="EMBL" id="RQTK01000575">
        <property type="protein sequence ID" value="RUS77506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BCL0"/>
    <dbReference type="STRING" id="188477.A0A3S1BCL0"/>
    <dbReference type="OrthoDB" id="6131156at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="8">
        <location>
            <begin position="39"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS77506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="305" mass="34620" checksum="F032420415E7F4B6" modified="2019-04-10" version="1">MCEITMEEFQEVCDMIFAIMQDIERKALTLEHINTKYPESQWTHIYTDGSAAEATFNGGCGVYIRYNDGEARLAKAAGKYSTNFRAEMEAITTAVTELRANLMRVKPKAVIFTDALSVLSKLRNPRQKDLGALEAALTNLTAVKDLTLQWVPAHCGIHGNEEADHLAKEAGQLEQNDKQVSYSEEKAIIKSLLRRKWKQQHPDFNKTDSYHHLSRPDQVIVLRLRTGHNRMNSHMYKKFKIGESEMCPCAEGEMNTEHLLQHCTLHSTARKEIWPDETSLREKLQGDLGALQRTASFVRTTGISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BCT5</accession>
    <name>A0A3S1BCT5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cystinosin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_014591</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cystine(out) + H(+)(out) = L-cystine(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:66172"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:35491"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:66173"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cystinosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000563">
        <property type="protein sequence ID" value="RUS77648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BCT5"/>
    <dbReference type="STRING" id="188477.A0A3S1BCT5"/>
    <dbReference type="OrthoDB" id="75720at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015184">
        <property type="term" value="F:L-cystine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000016">
        <property type="entry name" value="Cystinosin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000070">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005282">
        <property type="entry name" value="LC_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00951">
        <property type="entry name" value="2A43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131:SF5">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0769">Symport</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018588682" description="Cystinosin" evidence="12">
        <location>
            <begin position="22"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS77648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="44594" checksum="27D240358BABE1F2" modified="2019-04-10" version="1">MKVTNNGFLLLAIICIGHISGKNVTLEFSKSSLDIEVKETSKISITLSDKLIVDSELIFTYDDDYEDKYSNIKPLPNITVNATEGLRSWTIQVIGDQPGHVILGLDSPSTEIDDIRSSFVRIDVVHSSALVIVNAVIGWVYFVAWSISFYPQVYINWKRKSVIGLNFDFLCYNITGFLAYGFFNVGMYWVQEVKDEYFNNHPRGINPVQLNDVIFTLHAVLVTCVTIIQCLLYERGTQRVSYVCIVLVSGAWLFAGVSLVVTLIHKITWLTYLYYFSYIKLGVTLIKYVPQAHMNFKRKSTMGWSIGNVLLDFTGGSLSLLQMFLLSYNSDDWGSIFGDPTKFGLGFFSILFDILFIIQHYVLYRNKNPYEEITDKEVEINSPTDAPPPYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BCV2</accession>
    <name>A0A3S1BCV2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_006893</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000173">
        <property type="protein sequence ID" value="RUS85350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BCV2"/>
    <dbReference type="STRING" id="188477.A0A3S1BCV2"/>
    <dbReference type="OrthoDB" id="6235521at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="47"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="114"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="131"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS85350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="164" mass="17765" checksum="8D7658A3F8E22E8A" modified="2019-04-10" version="1">MNTLAVSDIYITRHTEQRLVAAAGAGDISTVRKLLRKNVPTSVLDEYGRTALHVASLDHHTETIKQLVLGGAALDAENCNRIAPIGLTRYDTDAWDVLNDARHGDMPELDEVLEVPDVPDYALPDGAEGKKGKKKKSGKKGKKGKGKKGKKSGGKKKGKKKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BD43</accession>
    <name>A0A3S1BD43_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_006685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000166">
        <property type="protein sequence ID" value="RUS85542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BD43"/>
    <dbReference type="STRING" id="188477.A0A3S1BD43"/>
    <dbReference type="OrthoDB" id="430364at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22088">
        <property type="entry name" value="F-box_FBXO8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048003">
        <property type="entry name" value="FBXO8_F-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF372">
        <property type="entry name" value="F-BOX ONLY PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="53"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="113"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS85542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="34566" checksum="FEAD7E0BC14DF948" modified="2019-04-10" version="1">MGQVLRRLQEVGIRPQDFLGFPIQDFARWDERETTTQQPRGSTIPAVALSTGFPDLANLPPELGLEVLSHLNATDLCLASCVWSQLANDELLWQSLCRSCWGSVSVYRHGRTAQFSYKQLFMLLDEACLTFNSDPFAGIGYLTSKGILEDRPIEIARFLHTTKRLWPNKKLEFLQQRTDVLECLVQLQNFQNQFLPNALRKFFKEVSAPQERGTTLTIMIENFSERFCTCNPKLGLGKDAVFVLCFSLIMLSVDLCSPHVKNKMSKREFIKNTCRAVAELSGDLAGHMYDNIYLAGHVAPKDFCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BDH8</accession>
    <name>A0A3S1BDH8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cilia- and flagella-associated protein 46</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_006385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000158">
        <property type="protein sequence ID" value="RUS85833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S1BDH8"/>
    <dbReference type="OrthoDB" id="68437at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035082">
        <property type="term" value="P:axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039586">
        <property type="entry name" value="CFAP46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15977">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15977:SF15">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="612"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="846"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1003"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1643"/>
            <end position="1690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2060"/>
            <end position="2088"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2318"/>
            <end position="2377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="850"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="877"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="897"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1004"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1652"/>
            <end position="1666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1674"/>
            <end position="1685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2061"/>
            <end position="2086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2321"/>
            <end position="2330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS85833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2396" mass="269401" checksum="A9B6FFE8DF34D39B" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BE23</accession>
    <name>A0A3S1BE23_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CFA20 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_010758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000336">
        <property type="protein sequence ID" value="RUS81460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BE23"/>
    <dbReference type="STRING" id="188477.A0A3S1BE23"/>
    <dbReference type="OrthoDB" id="7486196at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040441">
        <property type="entry name" value="CFA20/CFAP20DC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007714">
        <property type="entry name" value="CFA20_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12458">
        <property type="entry name" value="ORF PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05018">
        <property type="entry name" value="CFA20_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CFA20" evidence="1">
        <location>
            <begin position="44"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS81460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="233" mass="26932" checksum="F1028ADC5FE2E182" modified="2019-04-10" version="1" fragment="single">AKLTVSLQNLHLTTSTSCVRVVLGVGGASLGDHCNHRLILFTKMFKNTFQSGFLSILYSIGSKPLQIWDKKVRNGHIKRITDNDIQSLVLEIVGTNVSTTFITCPADPKKTLGIKLPFLVMIIKNLKKYFTFEVQVLDDKNVRRRFRASNYQSTTRVKPFICTMPMRLDDGWNQIQFNLSDFTRRAYGTNYIETLRVQIHANCRIRRVYFSDRLYSEDELPAEFKLYLPVQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BE66</accession>
    <name>A0A3S1BE66_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_010306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000314">
        <property type="protein sequence ID" value="RUS81920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BE66"/>
    <dbReference type="STRING" id="188477.A0A3S1BE66"/>
    <dbReference type="OrthoDB" id="8904524at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.20">
        <property type="entry name" value="Phenylalanine ammonia-lyase 1, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023144">
        <property type="entry name" value="Phe_NH3-lyase_shielding_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS81920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="25848" checksum="CE9992AC4D0B43CA" modified="2019-04-10" version="1" fragment="single">THTHILTPRLEQHITHILTPRLEQHITHVLTPRLEQHITHVLTQRLGQHITHVLTQRLGQHITHVLTQRLEQHITHVLTPRLGQHITHVLTQRLEQHITHVLTPRLGQHITHVLTSRLGQHITHVLTSRLGQHITHVLTPRLGQHITHVLTSRLGQHITHVLTPRLGQHITHVLTPRLGQHITHVLTPRFEQHITHVLTPRLGQHTTHVLTPRLGQHITCTDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BEX2</accession>
    <name>A0A3S1BEX2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_010125</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000302">
        <property type="protein sequence ID" value="RUS82113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BEX2"/>
    <dbReference type="STRING" id="188477.A0A3S1BEX2"/>
    <dbReference type="OrthoDB" id="411630at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15047">
        <property type="entry name" value="7tmC_GABA-B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06366">
        <property type="entry name" value="PBP1_GABAb_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF20">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 156-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01177">
        <property type="entry name" value="GABAB1RECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="417"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="464"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="598"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="640"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="664"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="12">
        <location>
            <begin position="430"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="365"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="730"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="371"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="398"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS82113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="780" mass="88529" checksum="271E1356EE9BE76B" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BF73</accession>
    <name>A0A3S1BF73_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_009624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000278">
        <property type="protein sequence ID" value="RUS82631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BF73"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS82631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="145" mass="16124" checksum="76CC8FB067721CFB" modified="2019-04-10" version="1" fragment="single">QQLEKAPEPLWPEEITPPIFEDLHYLGMLHAELFEEDVHIQAALSVQNVDLEKHESAYLHIFPLLLVIWHGIGGLPRTFGPTLQIDAEQFVHLLVIHLVFLRHSANHGPQVGFADHAGDGDLLPLQSLHLAPRLRGVGLGEVGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BFF7</accession>
    <name>A0A3S1BFF7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_009485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000273">
        <property type="protein sequence ID" value="RUS82747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BFF7"/>
    <dbReference type="OrthoDB" id="10393775at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018583415" evidence="1">
        <location>
            <begin position="19"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS82747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="216" mass="25279" checksum="78F92093122998C7" modified="2019-04-10" version="1">MGKHAIVAVLCILKGSCANHHHPWIHPCMPGHRVSSESISSDMNSLMQQRWMLHESINIAKHTARYLRLFISRNHLQNSYLRQECLNNTLLGMPDYPSTPVVETWQDNLSNDFHRLTLLIMYVYEAKLDAMDYSDRLHNFLTQLRDAACFMENTAILSNRELYYTVRPTSVPECYRYLPDQARRDRRNCLIARHAFDVLNVMSTTYRLIQPPTLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BH19</accession>
    <name>A0A3S1BH19_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UmuC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_004108</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000092">
        <property type="protein sequence ID" value="RUS88146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BH19"/>
    <dbReference type="STRING" id="188477.A0A3S1BH19"/>
    <dbReference type="OrthoDB" id="447129at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019985">
        <property type="term" value="P:translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000021">
        <property type="entry name" value="DNA polymerase IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000003">
        <property type="entry name" value="Polymerase (DNA directed) iota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053848">
        <property type="entry name" value="IMS_HHH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46404">
        <property type="entry name" value="DNA POLYMERASE IOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46404:SF1">
        <property type="entry name" value="DNA POLYMERASE IOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21999">
        <property type="entry name" value="IMS_HHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14377">
        <property type="entry name" value="UBM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UmuC" evidence="5">
        <location>
            <begin position="60"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="593"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="926"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="996"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1000"/>
            <end position="1025"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS88146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1034" mass="114836" checksum="1C087AC23D2BA995" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BIE6</accession>
    <name>A0A3S1BIE6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_007711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000202">
        <property type="protein sequence ID" value="RUS84542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BIE6"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS84542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="208" mass="22142" checksum="E5DCC69F718404C6" modified="2019-04-10" version="1" fragment="single">STPICISNLVYAPAICISNLVYAPAICISNLVYSPAICISNLVYAPAICISNLVYAPAICILNLVYFPAICISNLVYSSAICISNLVYSPAICIANLVYFPAICIPNLVYSPAIFISNLVYSPAICIPNLVYSPAICIPNLVYSPAICIPNLVYSPAICIPNLVYSPAICIPNLVYSPAICIPNLVYSPAICIPNLVYSPAICIPNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BIU7</accession>
    <name>A0A3S1BIU7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3'-5' exonuclease</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Werner Syndrome-like exonuclease</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_010444</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Has exonuclease activity on both single-stranded and duplex templates bearing overhangs, but not blunt ended duplex DNA, and cleaves in a 3'-5' direction. Essential for the formation of DNA replication focal centers. Has an important role in maintaining genome stability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the WRNexo family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000320">
        <property type="protein sequence ID" value="RUS81807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BIU7"/>
    <dbReference type="STRING" id="188477.A0A3S1BIU7"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06141">
        <property type="entry name" value="WRN_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051132">
        <property type="entry name" value="3-5_Exonuclease_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620:SF109">
        <property type="entry name" value="3'-5' EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620">
        <property type="entry name" value="3-5 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="12">
        <location>
            <begin position="76"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS81807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="266" mass="30351" checksum="A0008825FFB32F0C" modified="2019-04-10" version="1">MTTAAKAKKRSLPQWMVAVKEQQERDKPFKSPQNFTDSLKVKKVQTVEHGVSKIGCQSASDIISEDMPWLKFEGSITYSYHESDCACICQDILSRLGRDLPPVTVIGFDTEWPVTYNKGLPKKTAVIQMCLSKKECYLFHVSCMSTIPKPLQSVILDKRVILVGVNIESDLWKLERDYDLKVKPAIDQETVVDLSKLANVKLKSSERWSLDGLCRNVLRKRLDKDRDLRCGNWDDYPLSKDQKMYASNDAFASLELYTCLASREKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BKD2</accession>
    <name>A0A3S1BKD2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_009408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000269">
        <property type="protein sequence ID" value="RUS82832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10669609at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="588"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="739"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="848"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="933"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="969"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1044"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="372"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="982"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1049"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1089"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1112"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1131"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS82832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1389" mass="147110" checksum="193AEE9F656DCB0B" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BLE8</accession>
    <name>A0A3S1BLE8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Elongation factor 1-alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_008718</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000240">
        <property type="protein sequence ID" value="RUS83539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BLE8"/>
    <dbReference type="STRING" id="188477.A0A3S1BLE8"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03693">
        <property type="entry name" value="EF1_alpha_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03705">
        <property type="entry name" value="EF1_alpha_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000003">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000005">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000090">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008969">
        <property type="entry name" value="PRK12317.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="5"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS83539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="461" mass="50332" checksum="AFB5690813A5B968" modified="2019-04-10" version="1">MGKEKIHINIVVIGHVDSGKSTTTGHLIYKCGGIDERTIQKFEKEAQEMGKGSFKYAWVLDKLKAERERGITIDIALWKFSTEKYHVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGTGEFEAGISKEGQTREHALLAYTLGVKQLIIGVNKMDNTTPPYSETRFKEIEKEVSSYIKKIGYNPKAVAFVPISGWVGDNMLEESANMGWYKGWAVERKEGNASGKTLINALDSILPPTRPKDKALRLPLQDVYKIGGIGTVPVGRVETGIIKPGMVVTFAPPLVTTEVKSVEMHHESLTEATPGDNVGFNVKNVSVKDIRRGNVCGDSKNDPPKGAKMFHAQVIILNHPGEIKNGYAPVLDCHTAHIACKFHEIKEKVDRRSGKKLEDMPKSVKSGDAAMVDLIPSKPMCVEAFVDYPPLGRFAVRDMKQTVAVGVIKTVEKAEAAGGKVTKAAQKKGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BPQ5</accession>
    <name>A0A3S1BPQ5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_020391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001151">
        <property type="protein sequence ID" value="RUS71844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BPQ5"/>
    <dbReference type="STRING" id="188477.A0A3S1BPQ5"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS71844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="196" mass="20557" checksum="DC52CAB7BDC28DD6" modified="2019-04-10" version="1" fragment="single">VTASLNSFSFLVAASLNSFSFLVTASLNSFSFLVAASLNSFSFLVTASLNSFSFLVAASFNSSFLVTASLNSFSFFVAASLNSFSFLVAASLNSFSFLVAASLNSFSFLVAASLNSFSFLVAASLNSFSFLVAASLNSFSFLVAASLNSFSFLVAASLNSFSFLVAASLNSFSFLVATSFNSFSFLTLQCDTVLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BSD9</accession>
    <name>A0A3S1BSD9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha-mannosidase</fullName>
            <ecNumber evidence="8">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_018414</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 2 H2O = 2 alpha-D-mannopyranose + an N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:56052"/>
            <dbReference type="Rhea" id="RHEA-COMP:14368"/>
            <dbReference type="Rhea" id="RHEA-COMP:14369"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28729"/>
            <dbReference type="ChEBI" id="CHEBI:60615"/>
            <dbReference type="ChEBI" id="CHEBI:60625"/>
            <dbReference type="EC" id="3.2.1.114"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="RQTK01000896">
        <property type="protein sequence ID" value="RUS73821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BSD9"/>
    <dbReference type="STRING" id="188477.A0A3S1BSD9"/>
    <dbReference type="OrthoDB" id="10261055at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004572">
        <property type="term" value="F:mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.50:FF:000001">
        <property type="entry name" value="Alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.110.10:FF:000010">
        <property type="entry name" value="Alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="entry name" value="Glycoside hydrolase 38, N terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="entry name" value="Glycoside hydrolase family 38, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050843">
        <property type="entry name" value="Glycosyl_Hydrlase_38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11607">
        <property type="entry name" value="ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11607:SF70">
        <property type="entry name" value="ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="Families 57/38 glycoside transferase middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 38 central" evidence="10">
        <location>
            <begin position="467"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS73821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1124" mass="128012" checksum="D26D2DF75E428600" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BVL3</accession>
    <name>A0A3S1BVL3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Dynein axonemal heavy chain 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Axonemal beta dynein heavy chain 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Ciliary dynein heavy chain 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">EGW08_002412</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">EC2010</strain>
            <tissue evidence="25">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Consists of at least two heavy chains and a number of intermediate and light chains.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">The dynein complex consists of at least two heavy chains and a number of intermediate and light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000047">
        <property type="protein sequence ID" value="RUS89800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S1BVL3"/>
    <dbReference type="OrthoDB" id="5593012at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000038">
        <property type="entry name" value="AT13908p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000002">
        <property type="entry name" value="Dynein axonemal heavy chain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.130:FF:000005">
        <property type="entry name" value="Dynein axonemal heavy chain 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002141">
        <property type="entry name" value="Dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000003">
        <property type="entry name" value="Dynein heavy chain 12, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000002">
        <property type="entry name" value="Dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000223">
        <property type="entry name" value="Dynein heavy chain 3, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000044">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001328">
        <property type="entry name" value="Dynein heavy chain 6, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000001">
        <property type="entry name" value="dynein heavy chain 7, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000005">
        <property type="entry name" value="Dynein, axonemal, heavy chain 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000006">
        <property type="entry name" value="Dynein, axonemal, heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000362">
        <property type="entry name" value="Dynein, axonemal, heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000037">
        <property type="entry name" value="Dynein, axonemal, heavy chain 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:005585">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF71">
        <property type="entry name" value="DYNEIN, AXONEMAL, HEAVY CHAIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0966">Cell projection</keyword>
    <keyword evidence="13" id="KW-0969">Cilium</keyword>
    <keyword evidence="12 22" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0243">Dynein</keyword>
    <keyword evidence="10" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="14" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="24">
        <location>
            <begin position="1328"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="24">
        <location>
            <begin position="1984"/>
            <end position="2131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="92"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="22">
        <location>
            <begin position="687"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="22">
        <location>
            <begin position="2824"/>
            <end position="2886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="25">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00057074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00062885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00071816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00078543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00082102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="RUS89800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="3905" mass="446618" checksum="3365EF4EF3E95DAF" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BVX3</accession>
    <name>A0A3S1BVX3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_002173</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000041">
        <property type="protein sequence ID" value="RUS90060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BVX3"/>
    <dbReference type="STRING" id="188477.A0A3S1BVX3"/>
    <dbReference type="OrthoDB" id="6161365at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF40">
        <property type="entry name" value="LD47995P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0915">Sodium</keyword>
    <keyword evidence="6" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS90060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="206" mass="21615" checksum="7C962D428908397C" modified="2019-04-10" version="1">MLYLLGPTYMLAVMLFLYEGIVAFSFYQSKGCDPLASKQITSSSQLVPLLVKNILGSVPAMPGLFLAALFSASLSNYVAWEEKSELITMNIPTVVVLGVIACSFSFMAAELGGTLLQGAFAGGVVSFALGLWLSLGSSFSPDVPRPVMLQFASTDRCVAGWTNSSILINTTYAAAMNVSDMTAPTTAAYPSPLDEVSTLAPVSSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BW23</accession>
    <name>A0A3S1BW23_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LRRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_015932</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000673">
        <property type="protein sequence ID" value="RUS76308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BW23"/>
    <dbReference type="STRING" id="188477.A0A3S1BW23"/>
    <dbReference type="OrthoDB" id="6134357at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF161">
        <property type="entry name" value="TIR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="LRRCT" evidence="5">
        <location>
            <begin position="146"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="266"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="335"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS76308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="406" mass="45405" checksum="0103617D70C69E7F" modified="2019-04-10" version="1">MFSSGLQFLQTIRLSNNQLGALMADSFVGLGSLATLTLASNPLTFIEQGAFRNLANLTTLDLSYVEGGHVELQYDFLQEMLRLETLNLFGSTHLAQRVLDKVRDAGHVTPLSELQTMDVRYANLQTVPSRVRQLFPNMRSFLLDGNPLRCTESLRWLRQWMDEAGSTVQFHEHAEPTCNSPLRLRGRALASLAHAEWGADDEVDALRPAAGGDGSYGYNGGMVNDQPQEHQQGMPVDGQYFMRPMPVEEAKAPKSGPQIQNEAETQELGSKMAASQEGKMAAKQDGKMAASKEGKMADKSKSMPRPMNMVLAPAGGLENTKGRDGKDMEVTPAGKVKKYRRDRKNGKKMGRKGRKINRRQGRRGKKGRKLGRGKTRNRKDRQNMKNRKNRERKRRRRVTVHTGKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C1E5</accession>
    <name>A0A3S1C1E5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_011943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000400">
        <property type="protein sequence ID" value="RUS80305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C1E5"/>
    <dbReference type="OrthoDB" id="10522082at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018774175" evidence="1">
        <location>
            <begin position="21"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS80305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="162" mass="17553" checksum="2404B609149F6594" modified="2019-04-10" version="1">MKIFVATAVLAAVLLAHTDAALVKRNIFTNAKDILQNFEEELVAKTYPKLVSLGQAGVNAVRYLALSSNEDSLGPLKKDYKLAKNMVGEVVDGELFDEIVDQLIPLIDDENTVSGCVEVCGQTAKFTDDKTVEGLAMFTCPALCHAALTKLRHAAETLEDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H2L9</accession>
    <name>A0A3S1H2L9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-threonine 3-dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.1.1.103</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_021261</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate, mediating L-threonine catabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-threonine + NAD(+) = (2S)-2-amino-3-oxobutanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78948"/>
            <dbReference type="EC" id="1.1.1.103"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.103" evidence="5"/>
    <dbReference type="EMBL" id="RQTK01001292">
        <property type="protein sequence ID" value="RUS70979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H2L9"/>
    <dbReference type="STRING" id="188477.A0A3S1H2L9"/>
    <dbReference type="OrthoDB" id="10058185at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008743">
        <property type="term" value="F:L-threonine 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000077">
        <property type="entry name" value="L-threonine 3-dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051225">
        <property type="entry name" value="NAD(P)_epim/dehydratase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42687">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42687:SF1">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="7">
        <location>
            <begin position="64"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00050613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00059023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00066604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00069940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS70979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="383" mass="42921" checksum="BF7FE1F45F67033C" modified="2019-04-10" version="1">MATGRLSRTFVRMVSTGTPASSLVSPKTPMPPRAVTRLGGGAGALSSRRESHGFYKDVETRPRVLITGALGQLGPGLAQILRDRFGRDNVIMSDINKASDAVLESGPFLYADIMDMRALREICVNYEIDWLVHFGALLSAVGESNVPLAMQVNIEGVHNALEVARQYKMKLFLPSTIGAFGPDSPRDPTPDLCIQRPRTIYGVSKVHAELMGEYYHHKFGLDFRSLRYPGVISTDLPGGGTTDYALHMFHDALTTKVHHCYLRPDTRLPMMYIDDLLTATANFMQAPDRALRMRTYNIGSVDFTPEELAAEIRKYVPDLEIVYKPDHRQEIADSWPQRFSFVSAEQDWGYRPLYDLSGMCEIMIQSLLPKYKSAGRVKEEVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H5I6</accession>
    <name>A0A3S1H5I6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Spermidine synthase</fullName>
            <ecNumber evidence="4">2.5.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Putrescine aminopropyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_019603</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low activity towards 1,3-diaminopropane. Has extremely low activity towards spermidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12721"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="2.5.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer or homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.16" evidence="4"/>
    <dbReference type="EMBL" id="RQTK01001041">
        <property type="protein sequence ID" value="RUS72629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S1H5I6"/>
    <dbReference type="OrthoDB" id="38125at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.140.10:FF:000001">
        <property type="entry name" value="SPE3p Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000013">
        <property type="entry name" value="Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.140.10">
        <property type="entry name" value="Spermidine synthase, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030373">
        <property type="entry name" value="PABS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030668">
        <property type="entry name" value="Spermi_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035246">
        <property type="entry name" value="Spermidine_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037163">
        <property type="entry name" value="Spermidine_synt_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002010">
        <property type="entry name" value="PRK00811.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00417">
        <property type="entry name" value="speE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558:SF11">
        <property type="entry name" value="SPERMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558">
        <property type="entry name" value="SPERMIDINE/SPERMINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17284">
        <property type="entry name" value="Spermine_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000502">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01330">
        <property type="entry name" value="PABS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="12">
        <location>
            <begin position="6"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00072554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00082964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS72629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="327" mass="37124" checksum="C06024B72C48A2DE" modified="2019-04-10" version="1">MDAIREGWFSEMSEMWPGQCMSLEVEEVLHKEKSKYQDILVFKSKTYGNVLVLDGVIQCTERDEFSYQEMLAHLPLCSHKNPKKVLVIGGGDGGVAREVLKHPSVEEVHMCEIDERVVEVSKQFLPKMSCSFSNPKLKLHIYDGLEFMKAHQREFDVIITDSSDPIGPASALFEKQYYELMSTALKPGGIVCSQGECMWVHLDLIKSMRDFCKTIYPSVSYAYTTIPTYPCGQIGFMTCSLDKSLDFENPPNPLSAEDVDKFDLKYYNLDMHKSAFKLPEFARKALHSSDATNXXXXXXXXXXXXXXXXHTQSILMSLLNCMERAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H6K5</accession>
    <name>A0A3S1H6K5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_018976</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000958">
        <property type="protein sequence ID" value="RUS73257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H6K5"/>
    <dbReference type="STRING" id="188477.A0A3S1H6K5"/>
    <dbReference type="OrthoDB" id="1405469at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF187">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="228"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS73257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="497" mass="56070" checksum="C06AA554812CECA3" modified="2019-04-10" version="1" fragment="single">MFESSFLYKTFFLFVFLVLIYLSSLRSSGQDRSMSIEFLSNEEDDLTIDKAEHPILPGGGGMAICAHTCSSVKVQELNINDHGNINIGVTKVQSQKDLILSPKQHVKTVDVDSELNYHYQSKNVTSCISSSFSFSENISNSHSLFEYDVPLRTAVKTSNNIFSKLKLPEKEVSHKPSIQQSLEYDLSQSCSFATAVNPHDQGSSGAHDAITDFSSQVHKISGDIKLNWEVRSPEKHGSFGFSTNKYRRCHSQPESGMCTTDGEISNSYSNRDDAGNKNIVACQQYQKRGVSHDMASDVEEVIELFNHDDNFYNSITLYIQMELCGLTLQEWLVDRNLEFSTKGYDPKAMCVENMHIFHQLLQGVQFIHTSGVIHRDLKPRNIFLSTSDLQVKIGDFGLAKIEVLSQGSESLSVFKTWKDIPYIKDNHTSGVGTSAYASPEQLEGSLYDSKSDMFSLGVILFEIFHVFSTEMERVKSIEKIRRKNKCSFEFCESWPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HPP2</accession>
    <name>A0A3S1HPP2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_008541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GID4/VID24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000234">
        <property type="protein sequence ID" value="RUS83693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HPP2"/>
    <dbReference type="STRING" id="188477.A0A3S1HPP2"/>
    <dbReference type="OrthoDB" id="62at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018618">
        <property type="entry name" value="GID4/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534:SF3">
        <property type="entry name" value="GID COMPLEX SUBUNIT 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09783">
        <property type="entry name" value="Vac_ImportDeg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00061469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS83693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="212" mass="24780" checksum="207BBCD50EF71936" modified="2019-04-10" version="1">MESDEYRVITLADLDPSPPAYSRVTMKGIPTTLLYNGSRFQGDQTSKGNRYEVEVVLQHVDEEKAFLCGYLKIKGLTEEYPTLTTYFDGEIISRTHPFLTRKWDADEDVDRKHWGKFDSFHTCAKNFNADNFDYEALHASDFVYMRWKEHFLVPDHTIKDINGASFAGFYYICFQKSAATIEGYYYHRNSEMFQSLKLHHVPEKSTGVFQFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HXU3</accession>
    <name>A0A3S1HXU3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_003935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000087">
        <property type="protein sequence ID" value="RUS88297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HXU3"/>
    <dbReference type="STRING" id="188477.A0A3S1HXU3"/>
    <dbReference type="OrthoDB" id="5859304at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06769">
        <property type="entry name" value="PDZ_FRMPD1_3_4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000053">
        <property type="entry name" value="FERM and PDZ domain-containing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46221:SF3">
        <property type="entry name" value="FERM AND PDZ DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46221">
        <property type="entry name" value="FERM AND PDZ DOMAIN-CONTAINING PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="26"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS88297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="316" mass="35601" checksum="60E7D0BC2E7C5C1C" modified="2019-04-10" version="1" fragment="single">SHLEKYTTRDDPRLDPDYVEPPQPRQVELVRDLDKGFGFVAGSEKPVIVRCVTEGGPSVDKLLPGDLILKINGEEVRRAPKDKVIELVRSCKHSITLTVCQPYYDNSNRKSAILTPAKKARLKDNPSRVRFSDSVLVNGASVASQPSPQESYVYLMPNVLKVFLENGQTKSFKYDNKTTVKVFAGWDSVTVIKLAQNLPRHRLQVAERCDPLPPGEAEYFLHPALLSDAAEHEEQQCCNDVVHERFASEMKYDTALRLSALHIQQHAVSNNITGKISIKAIEKDTGLEKFVSPSLMENMKNKDLRKMLSQYLKIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1I0E4</accession>
    <name>A0A3S1I0E4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RIMB1/RIM3A-C-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_002452</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000048">
        <property type="protein sequence ID" value="RUS89749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1I0E4"/>
    <dbReference type="STRING" id="188477.A0A3S1I0E4"/>
    <dbReference type="OrthoDB" id="4158657at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007274">
        <property type="term" value="P:neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057950">
        <property type="entry name" value="RIMB1/RIM3A-C-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040325">
        <property type="entry name" value="RIMBP1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14234">
        <property type="entry name" value="RIM BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14234:SF19">
        <property type="entry name" value="RIM-BINDING PROTEIN, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25566">
        <property type="entry name" value="RIMB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIMB1/RIM3A-C-like N-terminal" evidence="3">
        <location>
            <begin position="52"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="50"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="184"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS89749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="271" mass="29964" checksum="DA30062001D23C8D" modified="2019-04-10" version="1">MEMRETSSCLFVRMVSGQAIGFRTSCGTMGAGHPQFCLVLLTRKEDREREKTLQKKLGELTGQIQRLERRISLLRTENDTLRKKQDDQRPLEEKIKSLKKRNAELASIARRLEEKAKALQLENSKVRAVGSKRLSASLPGVDESSIASNGSTSNATPTSASTTPTPTDSDHVRRVVARQRARDLAEHAKQMLAKDREIEQLRAKCQSLADQLSNGEIAAPANAAQFEDKEELVNIIKQAAKERLQLEHQLGSHAGGNVSVCVCVGVVWVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SJE7</accession>
    <name>A0A433SJE7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBFD1 PH-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_023024</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001776">
        <property type="protein sequence ID" value="RUS69217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SJE7"/>
    <dbReference type="STRING" id="188477.A0A433SJE7"/>
    <dbReference type="OrthoDB" id="267397at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039120">
        <property type="entry name" value="UBFD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057455">
        <property type="entry name" value="UBFD1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16470">
        <property type="entry name" value="UBIQUITIN DOMAIN-CONTAINING PROTEIN UBFD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16470:SF0">
        <property type="entry name" value="UBIQUITIN DOMAIN-CONTAINING PROTEIN UBFD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25343">
        <property type="entry name" value="PH_UBFD1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBFD1 PH-like C-terminal" evidence="2">
        <location>
            <begin position="44"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS69217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="116" mass="12571" checksum="DE229F222A7BD69B" modified="2019-05-08" version="1" fragment="single">MVIGSTLNDVLAVSAPTKTQLQDDEKSTAKAAKEPLSEQKQHKKVLDKYGKPEDVPVGVKGHSESLPQVPLSGMYNKSGGKVRLTFKLDSDQLWLGTKERTVKIPMPSIKGVVSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SJT6</accession>
    <name>A0A433SJT6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_022879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001714">
        <property type="protein sequence ID" value="RUS69354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SJT6"/>
    <dbReference type="STRING" id="188477.A0A433SJT6"/>
    <dbReference type="OrthoDB" id="8300047at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07574">
        <property type="entry name" value="nitrilase_Rim1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF50">
        <property type="entry name" value="HYDROLASE YHCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS69354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="285" mass="32503" checksum="55F42A45441468FA" modified="2019-05-08" version="1" fragment="single">VRLGLIQWQMRPYKSLDELMQHAEYFVNAVSNYRSDFALFPEFFNAPLMAENNHLSEPEAIRELAKHTKTITDKFSEFAIAYNINIITGSMPEIKDERLYNVGYLCRRDGTVEKYEKLHVTPDEAKVWGLQGGDKLEVFDTDCGKIGILICYDSEFPELSRILADEGMDILFIPFLTDTQNGFSRVRNCAQARAIENECYVAIAGSVGNLPKVHNMDIQYAQSMVFTPCDFAFPATGIKAEATPNTEMILIADVDISLLRELNQFGSVKNLRDRRKDLYELKRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SJX2</accession>
    <name>A0A433SJX2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_022869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001707">
        <property type="protein sequence ID" value="RUS69372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SJX2"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS69372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="106" mass="11974" checksum="3C447D5EB1C4FD57" modified="2019-05-08" version="1" fragment="single">TELVPLLHPRLTELVPLLHPRLTELVPLLHPPLTELVPLLHPPLTELVPLLHPRLTELVPLLHPRLTELVPLLHPRLTELVPLLHPPLTELVPLLHPPLTELVPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SP75</accession>
    <name>A0A433SP75_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_021232</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001288">
        <property type="protein sequence ID" value="RUS71010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SP75"/>
    <dbReference type="STRING" id="188477.A0A433SP75"/>
    <dbReference type="OrthoDB" id="29661at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098554">
        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030660">
        <property type="term" value="C:Golgi-associated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF103">
        <property type="entry name" value="INTRAMEMBRANE PROTEASE (IMPAS) FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="2">
        <location>
            <begin position="63"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS71010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="437" mass="49456" checksum="269607B8BCC555BE" modified="2019-05-08" version="1">MAWWAGFEGWTHAVGNAILQVVSEGGMPSTDKYCVQYNNQYQSLPNTQDKASPLNLKDLSDIEGCDLNEYKGHQIVSQHTLVAVTRGNCSFTQKALVAQAASAKAVLVVNYENSSFAPVPGGNKTEFGALNITLAVIAWNDFQAIVRSGGQVRASLYAPPRPLWDANMIFIIFGSTLLVIFGGAWAAYSEEQAVKQRLALARSRSNNANAEQNEEEEGLPITVCGVLIWFAFICGTILLLYFFYDYMVYVFIALFCFVGAHSLYRCLLPLWKRIMPINYDIPLNRLPCFKSKWFSYFRDICSWWLNNNPYQIGGPGLTVEIDESLVAKRKNHVGRVIEQSDGWAAYNGIVNIAVQPPYQHLVVNHSENFVDPQSGACTNTIKCYWKNCKRRFKSMLEVHREHLSSHLDEFMWRELHGKTPQEALQNIMLHLSQWYPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SSW2</accession>
    <name>A0A433SSW2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nuclear cap-binding protein subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_019880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NCBP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001076">
        <property type="protein sequence ID" value="RUS72364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SSW2"/>
    <dbReference type="STRING" id="188477.A0A433SSW2"/>
    <dbReference type="OrthoDB" id="422106at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019416">
        <property type="entry name" value="NCBP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16291">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16291:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10309">
        <property type="entry name" value="NCBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="246"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="318"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="604"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="762"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="834"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="373"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="432"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="468"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="521"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="676"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="776"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="789"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="803"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="863"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="894"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS72364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="924" mass="102760" checksum="593378CAF0F6C885" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433STU6</accession>
    <name>A0A433STU6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_019528</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001029">
        <property type="protein sequence ID" value="RUS72707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433STU6"/>
    <dbReference type="STRING" id="188477.A0A433STU6"/>
    <dbReference type="OrthoDB" id="2436605at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070652">
        <property type="term" value="C:HAUS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990498">
        <property type="term" value="C:mitotic spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007098">
        <property type="term" value="P:centrosome cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028346">
        <property type="entry name" value="HAUS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16039">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16039:SF1">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15003">
        <property type="entry name" value="HAUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS72707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="235" mass="26476" checksum="A0303541B5CA865A" modified="2019-05-08" version="1">MSEYHTPNRTSKFRPQVANPWENDSRAVTAIRNCLILAEQMGLRTMPKENEQRCAEQLASLPSTKIIEVQKELSSKTESLFQLQKNIAAHVHDKEAGDFLQIKNIEQRINMITQLCTDLDKVLQNTEALIHRLRKPFVGNFIKMDARYHSEACQVLKQLVPTLNDLASNINNITWAANHDFSAATLEALMVQIQSQIASTQTSLHNVNTLKHGILEVSTSSNRRGVTDNSADESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SUC2</accession>
    <name>A0A433SUC2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_019406</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001011">
        <property type="protein sequence ID" value="RUS72841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SUC2"/>
    <dbReference type="OrthoDB" id="419734at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="24"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS72841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="481" mass="53397" checksum="FF9BEBB526A0CC95" modified="2019-05-08" version="1">MGKNIYIRFCGFQFDLANITVEPVLFLYMFANFLYFPSYQALIFNKVCLHSYKDSEFCEALQHNKSFKDDHVHEDNDITSKTSYWTLNSNIALTTTSFFTTILFLGPFGDKWGRKVPVMIPCFGALFSYISGLLNAKFMSAPVVCIIVGPIINGLCGGFIACLMAVYSFVGHISSPSNKMIRVGIVEAMIFLAGSVGVFVSGPMLEKGYVATFSLLCISIGVAIIYAAFWLDNVQAATSEMLERESCGRAMLRFLSETLQCVRKTRRGWTLPALILQVLVLDMLMLCTSGDMDISLLYLRENLGFSQTMYGYVKGLDNFMRFSTLVFFLPFVKKLTTVKDLPLVIFGLISYAADYAITGLAGTKWLIYLAVCVGMFKGVPSAGLRATMSIMVSSEEQGRLFGLIAASESVVSLLASLLFNQLYPATLSFMPGLCYLLASGIIAAMVFVVVFIHYKMRAGSEEIPYMNFEEETNQVVNDPAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SUR5</accession>
    <name>A0A433SUR5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cas1p 10 TM acyl transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_019204</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PC-esterase family. CASD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000983">
        <property type="protein sequence ID" value="RUS73040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SUR5"/>
    <dbReference type="STRING" id="188477.A0A433SUR5"/>
    <dbReference type="OrthoDB" id="1932925at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012419">
        <property type="entry name" value="Cas1_AcylTrans_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13533:SF45">
        <property type="entry name" value="CAS1P 10 TM ACYL TRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13533">
        <property type="entry name" value="N-ACETYLNEURAMINATE 9-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07779">
        <property type="entry name" value="Cas1_AcylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Cas1p 10 TM acyl transferase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS73040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="302" mass="35273" checksum="78609B2FA8D560B0" modified="2019-05-08" version="1">MLFRLNFLVVFVAMVTNNGYMLYYICAMHTYWFITVYVFMRVLHSWNRNPRLMALKFAAYAFFNAIIFEIPGVSEKVFWPLHFVLGLDDGSPSIMHEWTFRSGLDHWACFCGMLCAYNYPHFENYMTYLDSKSADSKESLRKLLIRMGIAAACICLGCVWFFSVMGLEKYTYNSYHPYTSMIPVVCFIVLRNIHPKLRSYHIGLFAWLGKITLETYLSQLHIYLMANARTLLVFLDGYPMLNFALVTILYLVVSHRLFVITNDCSNFLLPHTKDMRRVLRNFACTALLFLLSMGVFFSVKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SVE8</accession>
    <name>A0A433SVE8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Meiosis-specific nuclear structural protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EGW08_018954</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">EC2010</strain>
            <tissue evidence="17">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis. Required for sperm flagella assembly. May play a role in the assembly and function of the outer dynein arm-docking complex (ODA-DC). ODA-DC mediates outer dynein arms (ODA) binding onto the axonemal doublet microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Flagellum axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000955">
        <property type="protein sequence ID" value="RUS73281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SVE8"/>
    <dbReference type="STRING" id="188477.A0A433SVE8"/>
    <dbReference type="OrthoDB" id="197839at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044782">
        <property type="term" value="P:cilium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026504">
        <property type="entry name" value="MNS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043597">
        <property type="entry name" value="TPH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19265">
        <property type="entry name" value="MEIOSIS-SPECIFIC NUCLEAR STRUCTURAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19265:SF0">
        <property type="entry name" value="MEIOSIS-SPECIFIC NUCLEAR STRUCTURAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13868">
        <property type="entry name" value="TPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="7 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="11" id="KW-0469">Meiosis</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trichohyalin-plectin-homology" evidence="16">
        <location>
            <begin position="81"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="191"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="276"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="387"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF13868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RUS73281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="471" mass="57903" checksum="0997525E201A60C6" modified="2019-05-08" version="1">MAMARQDKAMYIKREEVVTKKRLLRQQEVMKREMEMDEAITKGERNRIMKQQQMEQEENLARELERVKFEQLKDEKMRQQIRETSLELRELEAKLRAGYMNKERAAQMAEREAVKYDEMKRESEIARHMKEQNERAENAEQQRELERYKEMVRVRKLINKRYGQLEEQETKKQQAYEEFLKEKLMIDEIVRKIYEEDQRELERQMQKRQATQKYISEFKASRDAWKVEERKKMEEENAKILEFARRMQEREAILMSQKKEKDQAMVKVQVQLAQDIARKEAERTEMERVRMELVLEEQEERERQKEMSELERQIRQKIEMQSTHAQQMHYKALRMQAEKEEEDEFRKQMLAKFAEDDRIEQMNAQKRRMKQQEHARAVERLMEDRRAQFAREREAEASQRQEEARLEEFRKKIIEEERQKLLREHATKLIGFLPRGVIRDEDDLEMLGPQFQQAYTQRQIDPYDETTWETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SWV2</accession>
    <name>A0A433SWV2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">33 kDa inner dynein arm light chain, axonemal</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_018508</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the inner dynein arm light chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000906">
        <property type="protein sequence ID" value="RUS73728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SWV2"/>
    <dbReference type="STRING" id="188477.A0A433SWV2"/>
    <dbReference type="OrthoDB" id="273640at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097546">
        <property type="term" value="C:ciliary base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019347">
        <property type="entry name" value="Axonemal_dynein_light_chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13183:SF0">
        <property type="entry name" value="AXONEMAL DYNEIN LIGHT INTERMEDIATE POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13183">
        <property type="entry name" value="AXONEMAL INNER ARM DYNEIN LIGHT CHAIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10211">
        <property type="entry name" value="Ax_dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0243">Dynein</keyword>
    <keyword evidence="3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="177"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS73728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="29065" checksum="6AC6D479A5C049C3" modified="2019-05-08" version="1">MIPPNASLVKYDNPVLVSRNTDKKTPRAKALKASPTPPAAAGPLPVPPKGKGTPMDAKAAQQTDEILNSILPPREWTESGQLWVQQVSSTPATRLDVVNLQEELDRRLQQRQARETGICPVRRELYSQCFDELIRQVTINCAERGLLLLRVRDEIRMTIAAYQTLYESSVAFGMRKALQAEQGKADMEKKITELESEKRDLERQVNELKAKCEQTEKRAAELRQVEEKKHTEEIQFLKRTNQQLKTQLEGIIAPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SYN0</accession>
    <name>A0A433SYN0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VWFD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_017826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000833">
        <property type="protein sequence ID" value="RUS74408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SYN0"/>
    <dbReference type="STRING" id="188477.A0A433SYN0"/>
    <dbReference type="OrthoDB" id="6162288at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37860">
        <property type="entry name" value="AGAP008810-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37860:SF2">
        <property type="entry name" value="VITELLOGENIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFD" evidence="1">
        <location>
            <begin position="454"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS74408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="960" mass="107107" checksum="5111B59F8E499D8B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T0X1</accession>
    <name>A0A433T0X1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_017035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000763">
        <property type="protein sequence ID" value="RUS75198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T0X1"/>
    <dbReference type="OrthoDB" id="6088630at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS75198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="178" mass="20012" checksum="FDC2ADCB0A28B44A" modified="2019-05-08" version="1" fragment="single">MASYREDSYVDEICRFFRTPECYEPTVSECKGELRFASRAFRARQRYICGDRVARRGHNPFRSCVDEYEDNLGKCKESRSQELEELAYVSKASSESQVWCSVTSNYITCVYSVFALGCTLELADEYMASVNQSTPVVEAVYGYGCNFGHPLDILKTTTPVPETSPLGHDLGHGVYTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T2M0</accession>
    <name>A0A433T2M0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_016447</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the filamin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000711">
        <property type="protein sequence ID" value="RUS75786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T2M0"/>
    <dbReference type="STRING" id="188477.A0A433T2M0"/>
    <dbReference type="OrthoDB" id="18740at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21185">
        <property type="entry name" value="CH_jitterbug-like_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044801">
        <property type="entry name" value="Filamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537:SF8">
        <property type="entry name" value="FILAMIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537">
        <property type="entry name" value="JITTERBUG, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="4">
        <location>
            <begin position="49"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="145"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="238"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="330"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="419"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="511"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="609"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="701"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="779"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="869"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="972"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1007"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS75786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1007" mass="109780" checksum="ADD486E5775812A9" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T424</accession>
    <name>A0A433T424_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_015938</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000674">
        <property type="protein sequence ID" value="RUS76292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T424"/>
    <dbReference type="STRING" id="188477.A0A433T424"/>
    <dbReference type="OrthoDB" id="10003267at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029236">
        <property type="entry name" value="DUF4618"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28574">
        <property type="entry name" value="RIKEN CDNA 6820408C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28574:SF1">
        <property type="entry name" value="RIKEN CDNA 6820408C15 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15397">
        <property type="entry name" value="DUF4618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="167"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS76292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="369" mass="42790" checksum="7E5D14CC3B6050C5" modified="2019-05-08" version="1">MAAAWGKKAVGKIDRAHFENDELLKSLGNQLNVDFSKYDQWQRKERVMRPPAPKKKLPQDPMTFKVGTVARASSAESTPAPVPRGRRAQARYEEERRRQKEAVDMLEMRLRHAQQASDMYRKRAKELVDMNLSIAKDIEADEHETQVGVKRLLRKYEKFRGGIAALNSNFIKELSEVKHELEETKQSIGIKLAALNKELEEMDGKLKAKQEELNVLHSYKDKEYPVKAMMISNLHTELESVKNSNQEDQEELEHIINTELSKYDKERIQLSNEITKKVTEEAVALMHPSLKDMALQNIVMGKEIEFHKAQQIDLKDANKELEDEIKVLLRHPKSNVRLQLFPEFFPTREKCTPDMDVILDIPTQEWLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T557</accession>
    <name>A0A433T557_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_015586</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000646">
        <property type="protein sequence ID" value="RUS76656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T557"/>
    <dbReference type="STRING" id="188477.A0A433T557"/>
    <dbReference type="OrthoDB" id="6142483at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF417">
        <property type="entry name" value="CYTOCHROME P450 508B1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS76656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="37191" checksum="5E42771731706684" modified="2019-05-08" version="1" fragment="single">MVALLDNSTTLLIFVATILLVWYVTTLPSVRRMPPGPFPLPVLGNFLLLRMPGVDLMGTLSDLKNKYGKIFTLKIGSKPFIYINDLKLLQVELFHDLVVSFYKKNLFEQQEQVYIFHVIMLLLRVSLSNGQPWKELRRVSLTAMRDLGVGKRSLEEKVLEEVSVMLDIIGQQGGQPIVMKPWLVKATSNVISNVMFGSRFDFDDPRFNLLLQRLGEATNVNFLFTPANFFPLVRYFSKFEHKIIKTLETTSAYIKELVADHEETFDPDNIRDFVDLVLKMRNSPTGRHFNDLNMRRAIVDIFSAGSETTATTLQWLLYLMATYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T5X5</accession>
    <name>A0A433T5X5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_015372</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000628">
        <property type="protein sequence ID" value="RUS76862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T5X5"/>
    <dbReference type="STRING" id="188477.A0A433T5X5"/>
    <dbReference type="OrthoDB" id="411017at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652:SF50">
        <property type="entry name" value="PEROXIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="1" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS76862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="158" mass="18457" checksum="AE5052D486EB7299" modified="2019-05-08" version="1" fragment="single">MEVDFLDNIVKFNSLASGRDKLFRLVQYSSKFTWWYLQKYGISEELAVKLQRLSSALSTTRKFMRLGKSVDFLHGALRSIHLADHVLRYTITLSKLNQSVYLLFDHIVWAGRVGLAVIDKDKWGNLSARFWMVTIILNIIRDLYEIVGILFSEIRLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T761</accession>
    <name>A0A433T761_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CBM20 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_014809</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000581">
        <property type="protein sequence ID" value="RUS77431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T761"/>
    <dbReference type="OrthoDB" id="6123450at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32518">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32518:SF3">
        <property type="entry name" value="4-ALPHA-GLUCANOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM20" evidence="2">
        <location>
            <begin position="10"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="CBM20" evidence="2">
        <location>
            <begin position="116"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="763"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="763"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS77431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="914" mass="100566" checksum="E476FDA6C62B194C" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T8R3</accession>
    <name>A0A433T8R3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_014242</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000539">
        <property type="protein sequence ID" value="RUS77981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T8R3"/>
    <dbReference type="STRING" id="188477.A0A433T8R3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS77981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="164" mass="18874" checksum="F13FE4B70CD9800B" modified="2019-05-08" version="1" fragment="single">SPITHFADSRWAGWSNVTHFADSRWAGWSPITHFADSRWAGWSPITHFADSRWAGWSPITHFADSRWAGWSPITHFADSRWAGWSPITHFADSRWAGWSPITHFADSRWAGWSPITHFADSRWAGWSPITHFADSRWAGWSPITHFADSRWAGWSPITHFADSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TD44</accession>
    <name>A0A433TD44_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_012713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000446">
        <property type="protein sequence ID" value="RUS79515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TD44"/>
    <dbReference type="OrthoDB" id="6161632at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS79515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="613" mass="67376" checksum="DD39A9D5D2AAD26F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TFB8</accession>
    <name>A0A433TFB8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_011979</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000402">
        <property type="protein sequence ID" value="RUS80250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TFB8"/>
    <dbReference type="STRING" id="188477.A0A433TFB8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018983751" evidence="2">
        <location>
            <begin position="17"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS80250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="197" mass="22557" checksum="ACC255A61BD8D659" modified="2019-05-08" version="1">MLMGFCCLLLRPLVNDSRFSAEGDKKPQQMNQMTQKTQQMNQATEKTQQMNQATQKQMNQAAQNQMNQAAQNQMNQAAQKTQQMQQATSKTQQMQQATQNQMNQATPKPQQMNQATEKPQQMNQAAQKTQQMNQATQKTQQMNQATQNQMNQAAQKTQQMNQATQNQMNQAAQKTQPMNQATEKTQQMKQATRNPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TFL0</accession>
    <name>A0A433TFL0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_011875</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000395">
        <property type="protein sequence ID" value="RUS80378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TFL0"/>
    <dbReference type="STRING" id="188477.A0A433TFL0"/>
    <dbReference type="OrthoDB" id="4822at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040169">
        <property type="entry name" value="SUGP1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23340">
        <property type="entry name" value="ARGININE/SERINE RICH SPLICING FACTOR SF4/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23340:SF0">
        <property type="entry name" value="SURP AND G-PATCH DOMAIN-CONTAINING PROTEIN 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SURP motif" evidence="6">
        <location>
            <begin position="644"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="7">
        <location>
            <begin position="936"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="30"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="330"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="379"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="591"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="697"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="957"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="340"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="611"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="704"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS80378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1019" mass="111847" checksum="C65E1806655DF53C" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TFZ7</accession>
    <name>A0A433TFZ7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_011723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000387">
        <property type="protein sequence ID" value="RUS80502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TFZ7"/>
    <dbReference type="STRING" id="188477.A0A433TFZ7"/>
    <dbReference type="OrthoDB" id="6155388at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS80502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="103" mass="11486" checksum="755D4A37199BB1B6" modified="2019-05-08" version="1" fragment="single">MNTLPVSPTEIHLKWQAPLQGHVTRYHIRYWRPGRKEKQSAWVTGNFRNYVAGSLRKGSTYRFEIIPYNGAIPGTTSVMFASTPGDTPDGPPLNISLKAVNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433THW2</accession>
    <name>A0A433THW2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Galaxin-like repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_011043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000351">
        <property type="protein sequence ID" value="RUS81178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433THW2"/>
    <dbReference type="STRING" id="188477.A0A433THW2"/>
    <dbReference type="OrthoDB" id="6148295at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055284">
        <property type="entry name" value="Galaxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056601">
        <property type="entry name" value="Galaxin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34490:SF1">
        <property type="entry name" value="GALAXIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34490">
        <property type="entry name" value="PROTEIN CBG12054-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24748">
        <property type="entry name" value="Galaxin_repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019254381" description="Galaxin-like repeats domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="Galaxin-like repeats" evidence="2">
        <location>
            <begin position="35"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Galaxin-like repeats" evidence="2">
        <location>
            <begin position="297"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS81178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="709" mass="79791" checksum="FDA56DBA8E9C6367" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TIL1</accession>
    <name>A0A433TIL1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_010831</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000339">
        <property type="protein sequence ID" value="RUS81393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TIL1"/>
    <dbReference type="STRING" id="188477.A0A433TIL1"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000291">
        <property type="entry name" value="ALX homeobox protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003654">
        <property type="entry name" value="OAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF543">
        <property type="entry name" value="FI01017P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03826">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50803">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="316"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="OAR" evidence="9">
        <location>
            <begin position="556"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="318"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="168"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="249"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="294"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="294"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS81393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="574" mass="63384" checksum="D67F37D637D10BDD" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TIX4</accession>
    <name>A0A433TIX4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zinc finger matrin-type protein 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">U11/U12 small nuclear ribonucleoprotein 20 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_010712</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000332">
        <property type="protein sequence ID" value="RUS81542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TIX4"/>
    <dbReference type="STRING" id="188477.A0A433TIX4"/>
    <dbReference type="OrthoDB" id="2417221at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000741">
        <property type="entry name" value="Zinc finger matrin-type protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16465">
        <property type="entry name" value="NUCLEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16465:SF0">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="13">
        <location>
            <begin position="5"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="12">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS81542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="183" mass="20947" checksum="51EF713B3ACCB0FD" modified="2019-05-08" version="1">MGKRYYCDYCNKSFADNPVSRKTHLSGVVHAQNKRAHYDAFRDEEEILRDESNKRPCRTFLSSGQCKFGDRCQYSHLTNDDKAHLAEIVNHKRKLAEIKLQDTPQDVEDDSFIQSLDKWTKKRAEKKAQEDSAKDGPIPKQTFSAAIPDYQLAECLTSVVNPPPSLLPPTKEELLNAEYAEWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TJN6</accession>
    <name>A0A433TJN6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_010495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000322">
        <property type="protein sequence ID" value="RUS81741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TJN6"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS81741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="208" mass="24575" checksum="FE2C7DE9135EEDB3" modified="2019-05-08" version="1">MGHWSHTNMRACRELECDRMCCFSLETTRPHVGHCWRWSRAWYCLWRSRSCGDEKRAGHWPHRRMSRAWATRKWQVRLVLLGNTWPQRLHLNWWLSWCLASSARDGNLSLHCMQRNLSTVTWVSMWCCRLDSEENLSPQTQQRYGLSPVCSIVWIFRLSTDDTTKPQILHFIFSFLPLFGVSSPSIPDASPCALLSFPSTFTFSWRCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TMY5</accession>
    <name>A0A433TMY5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_009279</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000264">
        <property type="protein sequence ID" value="RUS82942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TMY5"/>
    <dbReference type="STRING" id="188477.A0A433TMY5"/>
    <dbReference type="OrthoDB" id="4748970at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050457">
        <property type="entry name" value="ZnFinger_BTB_dom_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105">
        <property type="entry name" value="AGAP004733-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105:SF5">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 44 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="11">
        <location>
            <begin position="221"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="113"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="27"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS82942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="283" mass="29273" checksum="B7140EF581EA3A79" modified="2019-05-08" version="1" fragment="single">MKLLEANPGTEASEPGSSLIMSSKVGTPSEAAAASSDSPTSATSTPSSTSSSSSSSSSLSSTAASSAFSFKNAEAGEVKDHASNGTHSSSSSNNNRSIDIGAGATSFPVTATTAAAATTARPDPSRKVPTKNGYAPNNDYSDNNNRSMRIITTTTSTSTRSTTSTNGSSSSSSGSSVVEPGLVFAAGPDGEEEERLEFREGQHPASVLASINSLRQQRQFCDVSLLVGEQEFPAHRAVLAACSPHLFDFLSCLEETAESRPIYKLGRDVAASGFRPLLDFMYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TPU2</accession>
    <name>A0A433TPU2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">YTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_008695</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000240">
        <property type="protein sequence ID" value="RUS83516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TPU2"/>
    <dbReference type="STRING" id="188477.A0A433TPU2"/>
    <dbReference type="OrthoDB" id="306690at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061157">
        <property type="term" value="P:mRNA destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.590.10:FF:000001">
        <property type="entry name" value="YTH domain family 1, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF89">
        <property type="entry name" value="YTH DOMAIN-CONTAINING FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="YTH" evidence="5">
        <location>
            <begin position="531"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="192"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="634"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="685"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="241"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="371"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="386"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="458"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="474"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="710"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="740"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="750"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS83516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="778" mass="82839" checksum="1C256F0D028EBF4E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TQ23</accession>
    <name>A0A433TQ23_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_008589</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000236">
        <property type="protein sequence ID" value="RUS83621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TQ23"/>
    <dbReference type="OrthoDB" id="6066475at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053231">
        <property type="entry name" value="GPCR_LN-TM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902:SF4">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="6">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS83621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="191" mass="20694" checksum="D437BE807D6F7CC6" modified="2019-05-08" version="1" fragment="single">SQVYAAVHHAAWLAAFLWLAAMSVNLARLLLCKMRPSSGTRCSRDFIVMAFLCWGIPVSVAGVCLALDINGFVDIGYGAAGVCFIGNAHSMLAVWIAPLMAILLLTIVCCLLVVRIVLKITPAQNKAPTKQSARRNQAVMCLFLSLLMGGNWIFYLVAAAKGDNDILWNLSILLNGCQGLYVMLCFVAKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TQF9</accession>
    <name>A0A433TQF9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_008426</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000229">
        <property type="protein sequence ID" value="RUS83814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TQF9"/>
    <dbReference type="STRING" id="188477.A0A433TQF9"/>
    <dbReference type="OrthoDB" id="62364at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051366">
        <property type="entry name" value="DEF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025258">
        <property type="entry name" value="RH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12326:SF12">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY AND RUN DOMAIN CONTAINING M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12326">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13901">
        <property type="entry name" value="RH_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01175">
        <property type="entry name" value="DUF4206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="6">
        <location>
            <begin position="749"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="112"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="207"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="331"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="434"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="511"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="816"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="274"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="333"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="369"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="512"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="835"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS83814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="847" mass="94098" checksum="ECFB79D0419240DD" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TS41</accession>
    <name>A0A433TS41_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_007883</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000208">
        <property type="protein sequence ID" value="RUS84351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TS41"/>
    <dbReference type="STRING" id="188477.A0A433TS41"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="497"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="527"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="497"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="527"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="130"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="258"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="429"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS84351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="557" mass="59984" checksum="F5B8B769C9077FFD" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TSB5</accession>
    <name>A0A433TSB5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_007760</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000204">
        <property type="protein sequence ID" value="RUS84464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TSB5"/>
    <dbReference type="STRING" id="188477.A0A433TSB5"/>
    <dbReference type="OrthoDB" id="7312725at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045914">
        <property type="entry name" value="Zn532-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041697">
        <property type="entry name" value="Znf-C2H2_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057356">
        <property type="entry name" value="Znf-C2H2_ZNF592"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47222:SF5">
        <property type="entry name" value="LOW QUALITY PROTEIN: ZINC FINGER PROTEIN 532-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47222">
        <property type="entry name" value="ZINC FINGER PROTEIN 532-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16622">
        <property type="entry name" value="zf-C2H2_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25412">
        <property type="entry name" value="zf-C2H2_ZNF592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="979"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="1210"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="104"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
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            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
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            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
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            <end position="809"/>
        </location>
    </feature>
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        <location>
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            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1178"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="115"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
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            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="723"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="796"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1055"/>
            <end position="1066"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS84464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1245" mass="137616" checksum="C449B978C8E2CE3F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TUJ7</accession>
    <name>A0A433TUJ7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_007072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000179">
        <property type="protein sequence ID" value="RUS85168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TUJ7"/>
    <dbReference type="STRING" id="188477.A0A433TUJ7"/>
    <dbReference type="OrthoDB" id="9860094at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027903">
        <property type="entry name" value="DUF4566"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15130">
        <property type="entry name" value="DUF4566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS85168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="228" mass="26949" checksum="29370847CD447B6A" modified="2019-05-08" version="1">MGDPLTRKSAAVSRLRNNLRKRREALADQFDFKMYIAFHFKDKKKKSTLFEVAEVYPVMTNNYEHSILEGVKNDSYTYESSRELIEKDVVQFHAHRWQPMRRDVIGCTSDVDFFLWPRNDIEKIECHLYSRWKGEDTPFRPLIVGYSFSSEEYVRQLMRLLTCRDKTGLIVTNTDQTVFLFVDKQHMQTSKNKVLVYKLQSVCLYLPQVQLMNWGPGTTEELIASYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TUR6</accession>
    <name>A0A433TUR6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_006999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000177">
        <property type="protein sequence ID" value="RUS85238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TUR6"/>
    <dbReference type="OrthoDB" id="6137223at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="437"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS85238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="512" mass="59498" checksum="F4BAF2030092A453" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TXP4</accession>
    <name>A0A433TXP4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_005939</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="RQTK01000143">
        <property type="protein sequence ID" value="RUS86295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TXP4"/>
    <dbReference type="STRING" id="188477.A0A433TXP4"/>
    <dbReference type="OrthoDB" id="5981550at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000004">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000003">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF9">
        <property type="entry name" value="HECT-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="9">
        <location>
            <begin position="540"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="90"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="116"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="193"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS86295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="879" mass="98145" checksum="334DDCA33C4F29C8" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TXY1</accession>
    <name>A0A433TXY1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_005835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000140">
        <property type="protein sequence ID" value="RUS86385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TXY1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS86385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="109" mass="12442" checksum="FB56FDCE64C1BC1D" modified="2019-05-08" version="1" fragment="single">LQKALRRREQAKSPKKVNKTLVRKDNQIKALMGELNMLQFYLDAQHKLTSEQREELVTARQEITKLRRSTSASLSSSNTRKSSQFSGSLGSKLTATRHPPDMMFQLGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TZ27</accession>
    <name>A0A433TZ27_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_005413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000127">
        <property type="protein sequence ID" value="RUS86817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A433TZ27"/>
    <dbReference type="OrthoDB" id="1918237at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12264">
        <property type="entry name" value="RRM_AKAP17A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056852">
        <property type="entry name" value="AK17A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12484:SF4">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 17A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12484">
        <property type="entry name" value="B-LYMPHOCYTE ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25015">
        <property type="entry name" value="RBD_AKAP-17A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="818"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="699"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="840"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="859"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="881"/>
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        </location>
    </feature>
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        <location>
            <begin position="1272"/>
            <end position="1282"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS86817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1282" mass="150478" checksum="CB6889D89BB3B26F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TZH3</accession>
    <name>A0A433TZH3_ELYCH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_005320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
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            <taxon>Lophotrochozoa</taxon>
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            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
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            <taxon>Plakobranchidae</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000124">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="6159105at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="31"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS86915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="190" mass="22141" checksum="D192D47CF5D773C2" modified="2019-05-08" version="1">MGFIGYEIFKRKKSFNARALYAKFGTTKIRKLKKASMRRLKERKKRMKEESKKRREENRTKKEGTKKAGAAKKIERTEKKKMKVEEKKKRKQEEAELKKAKKEKKREGKNKKKDPVLIEGQISQTVGDTDPVVDLYHSCVDMPNDTAETGDVTPYNLGRAEFNYYPVASPDPQVVQDWRLQVDNSEESPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
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    <name>A0A433U138_ELYCH</name>
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        </submittedName>
    </protein>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    <dbReference type="OrthoDB" id="6160986at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="599"/>
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    </feature>
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            <end position="883"/>
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        <location>
            <begin position="1"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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        </location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
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    </feature>
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        <location>
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        <location>
            <begin position="866"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS87543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="883" mass="97806" checksum="1B42FD018A9B2DA7" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U634</accession>
    <name>A0A433U634_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondria-eating protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Spermatogenesis-associated protein 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EGW08_002961</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">EC2010</strain>
            <tissue evidence="16">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MIEAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000060">
        <property type="protein sequence ID" value="RUS89287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U634"/>
    <dbReference type="STRING" id="188477.A0A433U634"/>
    <dbReference type="OrthoDB" id="5966837at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035694">
        <property type="term" value="P:mitochondrial protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035695">
        <property type="term" value="P:mitophagy by internal vacuole formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026169">
        <property type="entry name" value="MIEAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031981">
        <property type="entry name" value="MIEAP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21771:SF0">
        <property type="entry name" value="MITOCHONDRIA-EATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21771">
        <property type="entry name" value="MITOCHONDRIA-EATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16026">
        <property type="entry name" value="MIEAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondria-eating protein C-terminal" evidence="15">
        <location>
            <begin position="318"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="507"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="116"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="523"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RUS89287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="567" mass="64283" checksum="64DB2733A2147257" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U684</accession>
    <name>A0A433U684_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_002861</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000058">
        <property type="protein sequence ID" value="RUS89341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U684"/>
    <dbReference type="STRING" id="188477.A0A433U684"/>
    <dbReference type="OrthoDB" id="10059618at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061025">
        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08374">
        <property type="entry name" value="C2F_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037725">
        <property type="entry name" value="C2F_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037721">
        <property type="entry name" value="Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032362">
        <property type="entry name" value="Ferlin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546">
        <property type="entry name" value="FER-1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546:SF33">
        <property type="entry name" value="SPERM VESICLE FUSION PROTEIN FER-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16165">
        <property type="entry name" value="Ferlin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="11"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS89341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="301" mass="34861" checksum="2BEFF1BA4C0D238D" modified="2019-05-08" version="1">MWVDIFPSSLGPPGPPFDISPRKPLKYVLRVVIWNTKDVILEEESITGEKMSDIFLKGWMAGIDEKQKTDVHYRSLDGEGNFNWRMIFPFDYQVAEQTMVVRKKEHFWSLDETTLTTTPKFVTQVWDNDKFSADDFIGHLELNLNAMPMPAKRSKSCKLTMLPEVGKDVKLVSLFEMKHMRGFWPCYDDSTGTRELTGKIEMELELITEAEALERPAGQGREEPNMNPKLDPPNRPETSFLWFTSPWKTFKYIIWKNYGCWMICMVLFLLFLLLIAMFIYSFPSLMAELLVDALKGATGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U7U3</accession>
    <name>A0A433U7U3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Neurotransmitter-gated ion-channel ligand-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_002320</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000045">
        <property type="protein sequence ID" value="RUS89879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U7U3"/>
    <dbReference type="OrthoDB" id="6494256at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18989">
        <property type="entry name" value="LGIC_ECD_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000028">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5022265513" description="Neurotransmitter-gated ion-channel ligand-binding domain-containing protein" evidence="5">
        <location>
            <begin position="35"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="483"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="513"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="551"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="593"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="623"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="656"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="693"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="739"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="859"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="7">
        <location>
            <begin position="41"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="7">
        <location>
            <begin position="175"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="8">
        <location>
            <begin position="708"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="796"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="816"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS89879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="881" mass="97383" checksum="FCA6A51D5C468172" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U8N5</accession>
    <name>A0A433U8N5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="12">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EGW08_002048</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">EC2010</strain>
            <tissue evidence="16">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the UPL family. K-HECT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="12"/>
    <dbReference type="EMBL" id="RQTK01000038">
        <property type="protein sequence ID" value="RUS90169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A433U8N5"/>
    <dbReference type="OrthoDB" id="271273at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000013">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRIP12 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000005">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRIP12 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000689">
        <property type="entry name" value="HECT ubiquitin protein ligase family protein KAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057948">
        <property type="entry name" value="TPR_TRIP12_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018123">
        <property type="entry name" value="WWE-dom_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004170">
        <property type="entry name" value="WWE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037197">
        <property type="entry name" value="WWE_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF13">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25579">
        <property type="entry name" value="TPR_TRIP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02825">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00678">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117839">
        <property type="entry name" value="WWE domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50918">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 11 12" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="WWE" evidence="15">
        <location>
            <begin position="486"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="14">
        <location>
            <begin position="1413"/>
            <end position="1797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="69"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="570"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="710"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1213"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1370"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="731"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="801"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1377"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="11">
        <location>
            <position position="1764"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU369009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RUS90169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1797" mass="197054" checksum="BB0B016788CE08B3" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U945</accession>
    <name>A0A433U945_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_001940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000035">
        <property type="protein sequence ID" value="RUS90342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U945"/>
    <dbReference type="OrthoDB" id="5981048at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37917">
        <property type="entry name" value="PROTEIN CBG03580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37917:SF9">
        <property type="entry name" value="RHOPTRY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS90342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="125" mass="14256" checksum="C6D1605034C619FC" modified="2019-05-08" version="1" fragment="single">RLEVGGWRLELGAWRLEVGGWRLEVGAWSLELGGWRLEVGGWRLEVGAWRLRLGAWREVGGWRLEVGAWRLELGGWRLEVGAWSLELGGWSLELGAWSLEVGGWRLEVGGWRLEVGVWRLEVGAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UA25</accession>
    <name>A0A433UA25_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_001584</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNAP-25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000027">
        <property type="protein sequence ID" value="RUS90684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UA25"/>
    <dbReference type="STRING" id="188477.A0A433UA25"/>
    <dbReference type="OrthoDB" id="18679at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031629">
        <property type="term" value="P:synaptic vesicle fusion to presynaptic active zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016082">
        <property type="term" value="P:synaptic vesicle priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15856">
        <property type="entry name" value="SNARE_SNAP29C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15887">
        <property type="entry name" value="SNARE_SNAP29N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000041">
        <property type="entry name" value="Synaptosomal-associated protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305">
        <property type="entry name" value="SYNAPTOSOMAL ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305:SF9">
        <property type="entry name" value="SYNAPTOSOMAL-ASSOCIATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="7">
        <location>
            <begin position="93"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="7">
        <location>
            <begin position="241"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="258"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS90684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="306" mass="33997" checksum="D7D4F90D377EA12D" modified="2019-05-08" version="1">MSRYKSSNPFEDDDADDTDFVLVGKSKPAATYTYNSHTPSSSSQSNSVGKYQRPEKSHSSSAYSTSSTGYGYDGDAEANPFGDRRQQLMSQINESENRQLDSTQRALASIYESEAMGVATADELVRQGEVLDSIETKTDGMQQTLNTSQRHINNIKSVFGGIKNWWSGGGKKPAVNSQAQSNGANQRLRTTIEKQNAKGHTKVDTSGFYDDSDRDLDSRFMAGSRKPGDGQYTVIQPITRSAREDELDFNLGMMSEGMSRLKGLAQGLGDEIERQNEQLDRINVKVEDTDDLLSNQNRQMRRILKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UA84</accession>
    <name>A0A433UA84_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_001527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000026">
        <property type="protein sequence ID" value="RUS90723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UA84"/>
    <dbReference type="STRING" id="188477.A0A433UA84"/>
    <dbReference type="OrthoDB" id="6162526at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1138"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="708"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="757"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="804"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="821"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="832"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="854"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="874"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="968"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="984"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1042"/>
            <end position="1095"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS90723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1181" mass="129240" checksum="E27360228BFCF2D8" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UBX9</accession>
    <name>A0A433UBX9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_001039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000016">
        <property type="protein sequence ID" value="RUS91233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UBX9"/>
    <dbReference type="STRING" id="188477.A0A433UBX9"/>
    <dbReference type="OrthoDB" id="8178106at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028765">
        <property type="entry name" value="IQCB1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15673">
        <property type="entry name" value="IQ CALMODULIN-BINDING MOTIF CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15673:SF2">
        <property type="entry name" value="IQ CALMODULIN-BINDING MOTIF-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS91233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="319" mass="37298" checksum="0F8BA4ECC3A25135" modified="2019-05-08" version="1" fragment="single">RGLRPLLRRWEGRGFDRDLRHVGLLLESGSALRAKSQRNVECARYIQAVWRGFATRKKLKKANQAFAKFQKSYRLVLFCYRGRERRREFSPSLRCHTNALNVILLWCVYLSFPLTPARIEEFLKKEKSVAALRIQTLWRGHRERSKLTERQKVAQQVKAAIRIQRTFRRWLEKTETAKQEFPTHLKPHGLTDERRVELMKKISQWREQHPPQALDFADLQSLHSRGHAALAAHYKRVRPYRKLQAQAEGMVARLDTDTELLALAPPLKGVTEKDVAMYSSRSLPVAVAAKERHARVLRAKQLPWWRVLGEDQDADSEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UCK7</accession>
    <name>A0A433UCK7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_000661</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000009">
        <property type="protein sequence ID" value="RUS91546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UCK7"/>
    <dbReference type="STRING" id="188477.A0A433UCK7"/>
    <dbReference type="OrthoDB" id="9991832at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016176">
        <property type="term" value="F:superoxide-generating NADPH oxidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042554">
        <property type="term" value="P:superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051228">
        <property type="entry name" value="NADPH_Oxidase/PX-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706:SF2">
        <property type="entry name" value="SH3 AND PX DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706">
        <property type="entry name" value="SH3 MULTIPLE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="182"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="269"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="57"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS91546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="349" mass="38936" checksum="E2F5E94B55FA6C00" modified="2019-05-08" version="1" fragment="single">DFLATTDDELSAQTGDIVYKLFDDNEWVYVISEQGLEGFIPLICVSLLKDTSLNQEPKDSFKRKTKQSSLQLPQRTNDSMLAEEGSDASDGSRNTMTRVPQPKETDVVAPPKPARGLTLDIPDRINTSSSVSGEHNAVEATPQRNQRNSTSSHTFQQKTHLTSSQTSLSSDPITEVRTFSRKPRGKLLVIFPFEAWDEGDMSVDRGEVVTALNTEDPLWTMVRKLNGQEGFVPAAFTCNYPEDLPGAIGTGADNKSQRGDQQTKKPNYHDVRDLVTLRDFTAQSADDISVMVGEQVFADLANQIEREWLWVYAPSTGKYGYIPRDNVVHADRSPIPTELELRKFAQRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z5D7</accession>
    <name>A0A3S0Z5D7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">General transcription factor IIE subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Transcription initiation factor IIE subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EGW08_021183</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">EC2010</strain>
            <tissue evidence="17">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Tetramer of two alpha and two beta chains. Interacts with TAF6/TAFII80. Interacts with ATF7IP. Interacts with SND1. Part of TBP-based Pol II pre-initiation complex (PIC), in which Pol II core assembles with general transcription factors and other specific initiation factors including GTF2E1, GTF2E2, GTF2F1, GTF2F2, TCEA1, ERCC2, ERCC3, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2A1, GTF2A2, GTF2B and TBP; this large multi-subunit PIC complex mediates DNA unwinding and targets Pol II core to the transcription start site where the first phosphodiester bond forms.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIE alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001279">
        <property type="protein sequence ID" value="RUS71059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z5D7"/>
    <dbReference type="STRING" id="188477.A0A3S0Z5D7"/>
    <dbReference type="OrthoDB" id="361102at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000087">
        <property type="entry name" value="General transcription factor IIE subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039997">
        <property type="entry name" value="TFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017919">
        <property type="entry name" value="TFIIE/TFIIEa_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021600">
        <property type="entry name" value="TFIIE_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097:SF7">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11521">
        <property type="entry name" value="TFIIE-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02002">
        <property type="entry name" value="TFIIE_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51344">
        <property type="entry name" value="HTH_TFE_IIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HTH TFE/IIEalpha-type" evidence="16">
        <location>
            <begin position="15"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="319"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="355"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00065242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00080958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RUS71059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="412" mass="46658" checksum="F6C8C1C2287011D3" modified="2019-04-10" version="1">MEGSEALLTSVPEELKRLVRLIVRGFYSMEHAVIIDMLVRHPCVKEDDLSELLKLEKKHLRAILNMLKVDRFLKSKMRMETDSENRTTKHTYYYINYSVFVNVVKYKLDHMRRKIETDERDNTSRSSFVCPGCRKTYTDYEVKQLLDFNTGELVCTFCQSTVEEDESSVPRQDARTLLARFNEQIQPVVELLRVLEDVRLAPELLEPEPTDIRKFLSRNKDSSNSRSREGDRTAWSGDASRNVGFGFSENRVTIVMDEENSGKVEKKEQPLWMTKSTIDGATANSSAILEVKGPEPDKRGRAANGASDAILQALLVHEPQSGPSSSSAPSLHSALRRASSGDDSDAETAAKNGDELEEMDSEEEDDDGPMVSIGSERVPYNSITSEMVASMTPLEKEEYIRIGQQLYENMYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z8M0</accession>
    <name>A0A3S0Z8M0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_019003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000962">
        <property type="protein sequence ID" value="RUS73231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z8M0"/>
    <dbReference type="STRING" id="188477.A0A3S0Z8M0"/>
    <dbReference type="OrthoDB" id="3156807at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039904">
        <property type="entry name" value="TRANK1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21529">
        <property type="entry name" value="MAMMARY TURMOR VIRUS RECEPTOR HOMOLOG 1, 2 MTVR1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21529:SF4">
        <property type="entry name" value="TPR AND ANKYRIN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS73231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="210" mass="23786" checksum="874314E9640F76A5" modified="2019-04-10" version="1" fragment="single">EDLALLLSGNQRVSSHIEFGAHQAILVTCEESKARLPEVLSAGLVLTIYEAKGLEFDDVLLYNFFADSQADKEWRVVTEFLNQLAVDPVSSGGDNLVEIDSAVLELANRPRPLNFDPDQHKILNSELKQLYTAITRARVNVWIFDRDPQSRGPMFEYFKARKLVQCVQAKEGGSLSENYFFAQKSTPQQWRKSGDMFMSQKQFSLAAKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z9U8</accession>
    <name>A0A3S0Z9U8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_018245</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000877">
        <property type="protein sequence ID" value="RUS73996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z9U8"/>
    <dbReference type="STRING" id="188477.A0A3S0Z9U8"/>
    <dbReference type="OrthoDB" id="79562at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.320">
        <property type="entry name" value="Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033577">
        <property type="entry name" value="AOPep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038502">
        <property type="entry name" value="M1_LTA-4_hydro/amino_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015211">
        <property type="entry name" value="Peptidase_M1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46627">
        <property type="entry name" value="AMINOPEPTIDASE O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46627:SF1">
        <property type="entry name" value="AMINOPEPTIDASE O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09127">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01263">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal" evidence="9">
        <location>
            <begin position="600"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="613"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS73996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="759" mass="85977" checksum="ED9552B952F04BA3" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZAM7</accession>
    <name>A0A3S0ZAM7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_017668</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000819">
        <property type="protein sequence ID" value="RUS74562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZAM7"/>
    <dbReference type="STRING" id="188477.A0A3S0ZAM7"/>
    <dbReference type="OrthoDB" id="6152738at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034454">
        <property type="term" value="P:microtubule anchoring at centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18905">
        <property type="entry name" value="NINEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18905:SF13">
        <property type="entry name" value="NON-CENTROSOMAL MICROTUBULE ARRAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="17"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="92"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="141"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS74562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="327" mass="36687" checksum="D6F5851DF7546E5C" modified="2019-04-10" version="1">MSKRSGPLRSLNSGRDEYETRLKELFDESDESDKGHLNTVEVQALCSRLQLGRLRDRLIRALGERCVDKEKVQYTEFRHVFFALLEELEAQQSKSPSKQSQSDTEDKPDKSPKATPKLVLGRKQYGRRSLPISEDFGATAVMKSQEQHKSPPPPEGSYSQFLRDLDTNDRSSPSVDLKQDPARQTTSGFAHLNDPASTQGLAKPRPGVTRCDLLTRWRGGFTWDIIHKHVKRRRQSKGEQPSAMTSTAHPYEETYEAQGMLPTDEDVGPVLDDRTILHQLREVCGQVGLPDTGTLNLAQFAAVCAHIGLADVTDQVICCVWFVKQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZAN0</accession>
    <name>A0A3S0ZAN0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_018870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000944">
        <property type="protein sequence ID" value="RUS73368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZAN0"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS73368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="149" mass="17167" checksum="B15EB008258C548D" modified="2019-04-10" version="1">MTPVSAGHIILTPIQPVGNATARIRTRDLLRRKTMFYPWDTAPWPDSANECKRVRKEPPIQPQPHPSHQRQSGLGVKLVHLFSVWLSHQYLGPCDHWEHDEGEDDTQGNLNRCLITINASKNNRQAHGNKQTFECRTKVSYIIKIIWNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZDL3</accession>
    <name>A0A3S0ZDL3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">U1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_015709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000656">
        <property type="protein sequence ID" value="RUS76516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZDL3"/>
    <dbReference type="STRING" id="188477.A0A3S0ZDL3"/>
    <dbReference type="OrthoDB" id="6152290at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033375">
        <property type="entry name" value="Cggbp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32344">
        <property type="entry name" value="U1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32344:SF1">
        <property type="entry name" value="U1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS76516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="17278" checksum="A7DAD7671CEC3741" modified="2019-04-10" version="1" fragment="single">MDRFLKKDPKCARHTTAQERHSEFKSWTQVSGQLMFCTSCNIVLDHKRKSSVDIHASTLKHKNAIKRAADDSISGPTKRQKTLDCWLFLLISCDFSKFSPEKNDICTEWVAMCAAANIPLSKTDNPAVKKFLKEQVVNGGAIPTSTTLQRIYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZF77</accession>
    <name>A0A3S0ZF77_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_016025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000680">
        <property type="protein sequence ID" value="RUS76218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZF77"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS76218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="304" mass="32999" checksum="589ED595AB649BDE" modified="2019-04-10" version="1" fragment="single">QQSGHQQHHGHRASVKAGPATSQPGQSKDGKGGPVDEPPPGVTEPPPVIIDVHANSAGNQRRRSSATSENIRTQDLRDLLNKNSNNMNVLRARYDPDMMRHETLPADIKSKSHTNRRLSLVSGSDATHGEVRRRRSGENGSAPSVLDTVPSPVHDVRRRTMSLVAAQSDRRNSQSDRRNSQSDRRNSQSDRRNHGSERSHGSFRGGLYRESPMSAVEEEKEKSSPAENGTRIEHVSETEEAKHGLGANSGTPSRSRGVSSGFDNPAFDGVTGNVPSENAEADFRHGIGNPQPNKDASTKISTQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZFB5</accession>
    <name>A0A3S0ZFB5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_018616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000916">
        <property type="protein sequence ID" value="RUS73627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZFB5"/>
    <dbReference type="OrthoDB" id="6156745at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS73627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="385" mass="43681" checksum="004E63939C3FB3AD" modified="2019-04-10" version="1">MDFTQALNEAEAIGISRQQFLRIWECEEKMKYLDDELRQHQMRADVEKNCGDVATATSQIIQDQLQKFSIDQRRVLSNLREELQQQNQALITDISRMLEGFATMVGRVIKGELQTALAGLSLSETESNSSCSSNFSDTREVPQSLRHNNQGSTRVNNKEAENDRETVSSFESLRVEHAIGDLLSEADEETERNKNKGQINQKSTVAKKQCAEAQPINKNSENPTSSYEVSPNVLIFPEDMPVQMLVNDISNVSKSGKIIGSKIYHLQNSPFKVQLLLWFEGDEELKMNVKFWSLSPHPLKSSKRFIISGDIKNKNSSAYSSLFSEVSPPFNLQKPWSQNVDLPLLLKTKRGSYSDINLEALYNRNYVFEEGNSICINWSVLQQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZH14</accession>
    <name>A0A3S0ZH14_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">EGW08_017574</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">EC2010</strain>
            <tissue evidence="20">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000810">
        <property type="protein sequence ID" value="RUS74668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZH14"/>
    <dbReference type="STRING" id="188477.A0A3S0ZH14"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000003">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000277">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000033">
        <property type="entry name" value="paraplegin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF8">
        <property type="entry name" value="PARAPLEGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="19">
        <location>
            <begin position="408"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="154"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RUS74668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="841" mass="94229" checksum="51C8B4A9F84B8474" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZIJ9</accession>
    <name>A0A3S0ZIJ9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_012515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000431">
        <property type="protein sequence ID" value="RUS79742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZIJ9"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS79742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="110" mass="12688" checksum="80B9CE6FAF2EABB4" modified="2019-04-10" version="1" fragment="single">FGIQMLHIHMMIGVRIIPIHMMNGVQMQRIHMMIGAKMLHIHMMIGAKMLHIHMIIGAKMLHIHMMIGAKMLHIHLVIGAKMLHIHMVMALKITMMALPMTMEALRINMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZKC6</accession>
    <name>A0A3S0ZKC6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Very long-chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="17">1.3.8.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="34" type="ORF">EGW08_015396</name>
    </gene>
    <organism evidence="34 35">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="34 35" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="34">EC2010</strain>
            <tissue evidence="34">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Very long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, very long-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 12 to 24 carbons long primary chains.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>a very-long-chain 2,3-saturated fatty acyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = a very-long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:19181"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:83724"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="EC" id="1.3.8.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:19182"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>dodecanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-dodecenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47296"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57330"/>
            <dbReference type="ChEBI" id="CHEBI:57375"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:47297"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>eicosanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-eicosenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47236"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57380"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:74691"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:47237"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>octadecanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-octadecenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:71412"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:47241"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>oxidized [electron-transfer flavoprotein] + hexadecanoyl-CoA + H(+) = (2E)-hexadecenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:61526"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:43449"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>tetracosanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-tetracosenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47232"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:65052"/>
            <dbReference type="ChEBI" id="CHEBI:74693"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:47233"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>tetradecanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-tetradecenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47316"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:61405"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:47317"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 28">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; mitochondrial fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="20">Homodimer. Homodimerizes after import into the mitochondrion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 28">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="34">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.9" evidence="17"/>
    <dbReference type="EMBL" id="RQTK01000630">
        <property type="protein sequence ID" value="RUS76840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZKC6"/>
    <dbReference type="STRING" id="188477.A0A3S0ZKC6"/>
    <dbReference type="OrthoDB" id="2588832at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017099">
        <property type="term" value="F:very-long-chain fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01161">
        <property type="entry name" value="VLCAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000008">
        <property type="entry name" value="acyl-CoA dehydrogenase family member 9, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000006">
        <property type="entry name" value="very long-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000001">
        <property type="entry name" value="Very long-chain-specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049448">
        <property type="entry name" value="ACAD9/ACADV-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF11">
        <property type="entry name" value="VERY LONG-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21343">
        <property type="entry name" value="ACAD9-ACADV_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9 28" id="KW-0274">FAD</keyword>
    <keyword evidence="10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 28" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13 28" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="35" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0702">S-nitrosylation</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="32">
        <location>
            <begin position="95"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="31">
        <location>
            <begin position="208"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="30">
        <location>
            <begin position="322"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="ACAD9/ACADV-like C-terminal" evidence="33">
        <location>
            <begin position="523"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="29">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00039034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00040902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00045422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00046812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00049050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00049140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00049224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="Pfam" id="PF21343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="EMBL" id="RUS76840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="650" mass="70774" checksum="BBA4F2B390FCA4B3" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZLW7</accession>
    <name>A0A3S0ZLW7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_021811</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="RQTK01001411">
        <property type="protein sequence ID" value="RUS70428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZLW7"/>
    <dbReference type="STRING" id="188477.A0A3S0ZLW7"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="11"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="227"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS70428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="414" mass="45508" checksum="A53FA648FAA12EEC" modified="2019-04-10" version="1" fragment="single">HQQRRARGDNHRKRKSVLVFVHGGSYHHGMGAMLEGSHLAARDIIVVTFNYRLGALGNYGLRDQVLALRWVKDNIWHFGGDPTSVTLDGHSAGGCTVGLLALLPVAKGLFRRVIQQSGSPFSHWAITRRPSSPNLVFKLFTASLGCYGNGTAEVKACLKNVSSERMEEFVSSSPAVSNMVGAGFNVYTFLPFRYILHLCNTLSPPLPLPLPRPTCTCACLCVCMCPGVVHGSELFYLSGQPFWESRRHDTAGRTMASRLLHLWASFVTDGVPSLAPVDDFRMPKFTRESPIYTQMTSEHGRCVLKVGRGFKADKMAFWNRQVPLMYQEQLRQEIRLLEAQPSLPPLCTELSCGGQPAGVQPSPRSSLTSMSGHWALVTACLGQSALLVLLSVCYCHVRREVAALRRQAGLGTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZRB8</accession>
    <name>A0A3S0ZRB8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_011270</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRM elav family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000363">
        <property type="protein sequence ID" value="RUS80950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZRB8"/>
    <dbReference type="STRING" id="188477.A0A3S0ZRB8"/>
    <dbReference type="OrthoDB" id="266020at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050686">
        <property type="term" value="P:negative regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12650">
        <property type="entry name" value="RRM1_Hu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12652">
        <property type="entry name" value="RRM2_Hu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12377">
        <property type="entry name" value="RRM3_Hu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000006">
        <property type="entry name" value="ELAV-like 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000480">
        <property type="entry name" value="Fne, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000205">
        <property type="entry name" value="Sex lethal, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006548">
        <property type="entry name" value="ELAD_HU_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034775">
        <property type="entry name" value="Elav_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002343">
        <property type="entry name" value="Hud_Sxl_RNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01661">
        <property type="entry name" value="ELAV_HUD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00961">
        <property type="entry name" value="HUDSXLRNA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="98"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="191"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="355"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS80950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="437" mass="46958" checksum="E78310C49C691767" modified="2019-04-10" version="1">MVITTASAPSNCGNWVVNPCETVVAVPSKGLPYFTHPTSRSGMAQSCSQNTYPLCTPVMITLGDHAIMDQAGQQVVGGITQNGGTTSPSHSDDGVSKTNLIVNYLPQTMSQDEIRSLFSSIGELESCKLIRDKPTDPFTPSSGQSLGYGFVNYKRPEDAEKAINTLNGLRLQNKTIKVSLARPSSESIKGANLYISGLSKSMTQLDLEALFSQIGNIITSRILYDQTTGLSKGVGFIRFDQRCEAEKAIEKLNNKIPEGSIDPITVKFANSPSSNKNLAGMAPLALATYLSPTHRRFFGPIHHATASSRFRYSPLDSGLLPNTILPTTLTTAAATAAAAATSTSSSTTALNATGWCIYIYNLAPDTEDNVLWQLFGPFGAVQSVKVIRDYATSKCKGFGFVTMTQYEEALMAIQNLNGFTLGNRVLQVSFKASSRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZSJ2</accession>
    <name>A0A3S0ZSJ2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_018018</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000854">
        <property type="protein sequence ID" value="RUS74212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZSJ2"/>
    <dbReference type="STRING" id="188477.A0A3S0ZSJ2"/>
    <dbReference type="OrthoDB" id="75754at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15847">
        <property type="entry name" value="SNARE_syntaxin7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000059">
        <property type="entry name" value="Related to syntaxin 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF38">
        <property type="entry name" value="LD27581P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14523">
        <property type="entry name" value="Syntaxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="4">
        <location>
            <begin position="179"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS74212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="276" mass="31106" checksum="9501425A9B92EF89" modified="2019-04-10" version="1">MAGTYGAIREYRDDPDFRDYRDEDPVSSVSELTERIRSNIFKINNGANAVDRAMKNIGTERDSTQLRDRIHETSQGTAKVVQETTRLLRAAATKKADKQQKIQLDLLKSNFQDAVQRFQTLQKKAAAKVKSAVKLGSKRTSEPLIPIAGDDDRSPLAAEEEFQQNQMLKEQEVVIEDDLALIREREERIHQLESDILDVNEIFRELGAMVHAQGEVLDTIDQNLYTAADNVESGNEQLIQAAEYQRKSRRKMCCLLGIFMVVAAIIAIIVAVSLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZVM1</accession>
    <name>A0A3S0ZVM1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_005253</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="RQTK01000122">
        <property type="protein sequence ID" value="RUS87015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZVM1"/>
    <dbReference type="STRING" id="188477.A0A3S0ZVM1"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF203">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="105"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="264"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="310"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="343"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="423"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="440"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS87015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="548" mass="61208" checksum="B14C9B9CF25B9C51" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZYN3</accession>
    <name>A0A3S0ZYN3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_013806</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000510">
        <property type="protein sequence ID" value="RUS78432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZYN3"/>
    <dbReference type="STRING" id="188477.A0A3S0ZYN3"/>
    <dbReference type="OrthoDB" id="6162468at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024822">
        <property type="entry name" value="Coilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031722">
        <property type="entry name" value="Coilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056398">
        <property type="entry name" value="Tudor_Coilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15197:SF0">
        <property type="entry name" value="COILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15197">
        <property type="entry name" value="COILIN P80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15862">
        <property type="entry name" value="Coilin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23086">
        <property type="entry name" value="Tudor_Coilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coilin N-terminal" evidence="2">
        <location>
            <begin position="10"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Coilin tudor" evidence="3">
        <location>
            <begin position="722"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS78432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="821" mass="92732" checksum="74DF260FDD364ED5" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZYW7</accession>
    <name>A0A3S0ZYW7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_002122</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="RQTK01000040">
        <property type="protein sequence ID" value="RUS90080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZYW7"/>
    <dbReference type="STRING" id="188477.A0A3S0ZYW7"/>
    <dbReference type="OrthoDB" id="10263353at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02669">
        <property type="entry name" value="Peptidase_C19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000030">
        <property type="entry name" value="U4/U6.U5 tri-snRNP-associated protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033809">
        <property type="entry name" value="USP39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF16">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="6">
        <location>
            <begin position="58"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="432"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS90080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="449" mass="51503" checksum="9AD7A90F76D5C38C" modified="2019-04-10" version="1">MTQKFYCLPDNYQIIDSSLDDIIYVLNPTFSDLMIKRLDKNPKLSRAYDGTTYLPGIVGLNNIKANDYCNVVLQSLSHVAPLRNYFLKEDNYKKIKRPPGDIAFLLVQRFGELIRKLWNPCNFKAHVSPHEMLQAVVLCSKKRFQITKQGDPIDFLSWFLNATHSAMNGTKKMNSSIINKTFRGKMRVYSRKIPNVDLSDAEKAELLLLEEYQETAVEMPWLYLTCDLPAPPLYPDESRENIIPQVPFANLLTKFNGVTEKEYKSSKDSTMKRFELTRLPQFIIIYFKRFNKNYFVHEKNPTIVNFPIKNIDFGDLLAPEVRAQHKHTTYDLVANIVHDGQPGQGKGNYRCHVLHKGQGKWYEMQDLHVTDILPQMITLSESYIQIFEVRRDIPNPFYQAEANTESTETGEGGDQGEVQEGVMEISGDAAESVQQNIIDAQNTPETAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZZ70</accession>
    <name>A0A3S0ZZ70_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_005605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000132">
        <property type="protein sequence ID" value="RUS86656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZZ70"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS86656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="351" mass="39384" checksum="4788BC8393F1BD09" modified="2019-04-10" version="1">MGVLLSFSTSTGSYCGILNCKEEATALPGPILTLKKIETLVVFSKSGDKFTTVVRLENYGQTLKLDTEGWNIEGNITAGKANLNIVFKEQKYCAGDFTCQVTGEDAFGRLLTENSNIHIQSKLKSTTIPKLSNLSIAVHRGFSRAEKELDRRMSIKTKLLLEKFGRLTETFASTMKDSEKSLDEQVWKLLGHLDVLIEKLKYPKKETKDTKKDDTDTDDSYDEELQFVISLLFVDLRAKTIPEMIESISNGTLNFAMEPANAVRNVSESLENDLNRTSEFLQSLGQRFRDFKAYDDQVVLSLKEEVENFREILGAGTNAKCSFNEASDSEKVSVDYSTTSDQNQVRPDLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZZB4</accession>
    <name>A0A3S0ZZB4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peptidase M13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_013335</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000483">
        <property type="protein sequence ID" value="RUS78892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZZB4"/>
    <dbReference type="STRING" id="188477.A0A3S0ZZB4"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF195">
        <property type="entry name" value="ENDOTHELIN-CONVERTING ENZYME-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="9">
        <location>
            <begin position="93"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="8">
        <location>
            <begin position="569"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS78892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="779" mass="88757" checksum="E2D313F9AC7CA11B" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZZQ8</accession>
    <name>A0A3S0ZZQ8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nanos-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_005210</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the nanos family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000121">
        <property type="protein sequence ID" value="RUS87057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZZQ8"/>
    <dbReference type="STRING" id="188477.A0A3S0ZZQ8"/>
    <dbReference type="OrthoDB" id="10010129at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.30">
        <property type="entry name" value="Nanos, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008705">
        <property type="entry name" value="Nanos/Xcar2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038129">
        <property type="entry name" value="Nanos_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024161">
        <property type="entry name" value="Znf_nanos-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12887">
        <property type="entry name" value="NANOS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05741">
        <property type="entry name" value="zf-nanos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51522">
        <property type="entry name" value="ZF_NANOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nanos-type" evidence="10">
        <location>
            <begin position="438"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="65"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="152"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS87057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="506" mass="55987" checksum="1ACDF61A974504AC" modified="2019-04-10" version="1">MYTLVAPAQIWPHHAPMGHNQQQVIYSHFPTAYVMAPVPAQALYGQGFRPVYSGGQISAWSNTPAAAQAASAPDSEERMSSSDDDVFLPSQTSRKTNDAFYTGPYFIPRPAPSVASSGPETPKLNFANTMDAFCPSTPGIRLPEKYTRARAKIGARKNSERKIKRSSINGSLNSSGGTSGSSHNTTDQSIKQNSFGADLHLANLSDVLSANTSGSDVSPPGAAVRRRLDRSVAGEMCSVSSCVLPMSLRAALNEDPPEPTTACAPLKTSSPIRESDEFLSLPTVIPSKVQKAVRQTLAPMPVPIGAEIHQRKLNLQQAIRSEKENYNTMESENFLAESNQRKRRDGRYITGLATCQNNCCSPSDRKFPRVSTAEEEIAAAVASEAEDMDQCLRILKQREMTGAAEELARRREEFLLVLEAERERQRRLVLPKKAPKMNCKFCRNNGESEEIYTKHKLHDKERTVCPILRHYVCRLCNSTGDFAHTIRHCPFNNRKDRIAWKATFMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A2S2</accession>
    <name>A0A3S1A2S2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_011033</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000350">
        <property type="protein sequence ID" value="RUS81203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A2S2"/>
    <dbReference type="STRING" id="188477.A0A3S1A2S2"/>
    <dbReference type="OrthoDB" id="6262629at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="18"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS81203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="530" mass="58220" checksum="9905CBEEABFB0243" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A7I3</accession>
    <name>A0A3S1A7I3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_007635</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0669 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000200">
        <property type="protein sequence ID" value="RUS84608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A7I3"/>
    <dbReference type="STRING" id="188477.A0A3S1A7I3"/>
    <dbReference type="OrthoDB" id="10046613at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031420">
        <property type="entry name" value="UPF0669"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31703">
        <property type="entry name" value="UPF0669 PROTEIN C6ORF120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31703:SF2">
        <property type="entry name" value="UPF0669 PROTEIN C6ORF120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17065">
        <property type="entry name" value="UPF0669"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018778219" evidence="7">
        <location>
            <begin position="21"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS84608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="194" mass="22452" checksum="F168F39DA390FDC2" modified="2019-04-10" version="1">MLSFAVFLSLVFLALPGVAAIDGRVIQVLEDNIGAENFTYYRLQRPGMLRLELVSIKGDVDIYVSAEVQHPDYDFYDLKSDSCGTDIIIIPSKMQRPVFIAIFGHPNHIQSKYLLTIYELHEPLVEDYEYLVNKYERYYFEEMENEMTGNPKPLRQKEESPKEYSSASEEDEDAAPLWWEILLGILRFGIEVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AG94</accession>
    <name>A0A3S1AG94_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_001090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000017">
        <property type="protein sequence ID" value="RUS91177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AG94"/>
    <dbReference type="STRING" id="188477.A0A3S1AG94"/>
    <dbReference type="OrthoDB" id="8930856at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS91177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="757" mass="82530" checksum="A65A5E9FBF1074D5" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AGC9</accession>
    <name>A0A3S1AGC9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TNFR-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_000974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000015">
        <property type="protein sequence ID" value="RUS91262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AGC9"/>
    <dbReference type="STRING" id="188477.A0A3S1AGC9"/>
    <dbReference type="OrthoDB" id="6130170at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018550964" description="TNFR-Cys domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS91262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="15482" checksum="DF693A54E067FA86" modified="2019-04-10" version="1">MEHLVFFLVGLTAALAAQTGISCPKCTDAYDPTSCTQTQTCHNSHDVCELQIHLADNNRLSYVCHNSHACTNHEAHACSINDHEMCAYCCSSVDACKKQREEIFAKLPSQPQTTMAAMTNTTMTGMNNTMTGMNNTATNTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AGK9</accession>
    <name>A0A3S1AGK9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_000798</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000011">
        <property type="protein sequence ID" value="RUS91474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AGK9"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS91474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="230" mass="26077" checksum="B8033104EAB087EA" modified="2019-04-10" version="1">MESWRDAYNWERPTPSRGVDCKVFVFPLINYGLFWQGRDRAYARTSVSANVTCQEQDYPIRDRTNIDTDYNPCAEMGRFSLVFKRHQISFITDGSQDKRLTMLQHRDNRGIPGRLSQMLILYQHKPNHESKQISNLAELSQKGGKDGSKSLVHNTYFSFGGISVRDGLVWHCMAECGIYRFLLIATRGGIPACHLTILAHGEPGETTKGGEAENPACSTSVYCVYFAMHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AQ67</accession>
    <name>A0A3S1AQ67_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bacterial type II secretion system protein E domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_023392</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001975">
        <property type="protein sequence ID" value="RUS68846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AQ67"/>
    <dbReference type="STRING" id="188477.A0A3S1AQ67"/>
    <dbReference type="OrthoDB" id="10064660at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01129">
        <property type="entry name" value="PulE-GspE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.90:FF:000001">
        <property type="entry name" value="Type II secretion system ATPase GspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000398">
        <property type="entry name" value="Type IV pilus assembly ATPase PilB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30258:SF1">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN HOFB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30258">
        <property type="entry name" value="TYPE II SECRETION SYSTEM PROTEIN GSPE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacterial type II secretion system protein E" evidence="3">
        <location>
            <begin position="261"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS68846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="454" mass="50572" checksum="0D9B08FA43C67FC0" modified="2019-04-10" version="1">MLIKDKIEEFEEHLKAENQDDTESFNDKMDEFEFDLDLVDAGDRSADDLIGNADDDEAPIIRFINNTIVDAIQKGASDIHFEPYEKNFRIRYRIDGLLIETFNTNKNLGPKVVSRLKIMASLDIAEKRIPQDGKFKISLSHEKAIDFRVSSCPINFGEKVVLRIIDASSTQIPVEALGFSQHQKEIYLNAISQSQGMVLVTGPTGSGKTVTLYTGINILNKPEKNISTAEDPVELAVRGINQVNVNNKQGLTFAAALKSFLRQDPDIIMVGEIRDIETGSIAIKASQTGHLVLSTLHTNSAPETLNRLVDMGLPRYNIATSVTLIIAQRLTRRLCKNCKIIDENEDFATIVKDSEVTDKILETFDTTLEELKKAKAYKPNIKGCPKCFKGYKGRVGLYEVMPVSRKIAKMILEDKNTMEIAAQAQAEGVANVRQTGLVRVAEGLTSMEEIYRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1ATA8</accession>
    <name>A0A3S1ATA8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_020713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001201">
        <property type="protein sequence ID" value="RUS71528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1ATA8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS71528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="220" mass="24885" checksum="750D8536FE9340A8" modified="2019-04-10" version="1">MGDPVTAKPLVSSEPHRPSDGLTGGWDELKALSLGLDMNCQQRIWLLINTTNTDAGETRRNPRKEDLPVSRNWKQVRGRPLSLNSYNYKVRTMAKIKSARERSGSLSLSVSTIHSIALQTAQGEASASWERWPEKERKKKNKNKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKRGETSIDNMKTTRNGKQKTGDGGISLAVILVALTQAVTVRAHCLTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AVQ1</accession>
    <name>A0A3S1AVQ1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_018721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000928">
        <property type="protein sequence ID" value="RUS73506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AVQ1"/>
    <dbReference type="OrthoDB" id="6136444at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS73506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="287" mass="32145" checksum="B8C7E51FB2FD4066" modified="2019-04-10" version="1">MCNSCKSRMESMETTEVCKSNSVEETENFKAKNAEPRRSDEKDFQVAQERVQNEDRDNDKTSSTLPEGERALNVETPTTSLDTDSENASSSPELAHLRAPPQHCVSGFFRIHTANHVVFDDAEARQTIVEFFYDDHRDVRHVIRARGVRVTRSDLDGDYCVLDCVTHDAKLGPALDAVRREWSSLWNEVKDKLYGSDVSMVVSHPHGCSKQFSVGRCLSREWGQAAGGQGWYRYTYDVPTCPGSSGAPVWVPGRDGLLSGYAPHSGSFNADVARSAVWFFWNMPQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AYX2</accession>
    <name>A0A3S1AYX2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_021442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001332">
        <property type="protein sequence ID" value="RUS70794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AYX2"/>
    <dbReference type="STRING" id="188477.A0A3S1AYX2"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001927">
        <property type="entry name" value="Receptor protein-tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000615">
        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS70794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="271" mass="31282" checksum="DE6062F01B34F98C" modified="2019-04-10" version="1" fragment="single">VFIFIFSENASEKDKEDFLNEFDILKRVGKHENVVCLVGACHIGGVMYVAMEFAKHGDLRTFLRHSRRLTSVHEYDNTSCPSVRAALRPETLINLALGTARGLRHLSDKQTEVNVYPYCLVLYVSQWVILDVKQPTQLNSTPSTLCPSQTRVPIRWMAVESLFNNTYTLQSDVWSFGVLLWEIFTLGGTPYAAIDSQQLFSYLKEGHRLRKPRLCEQDMYAMMLQCWHDCPKRRPVMEELVARLHKMLEKSEVYINLSSQEEALYAEIDHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AZR5</accession>
    <name>A0A3S1AZR5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_019717</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001058">
        <property type="protein sequence ID" value="RUS72521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AZR5"/>
    <dbReference type="OrthoDB" id="6144763at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS72521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="25157" checksum="6381864FD6F9D4AC" modified="2019-04-10" version="1">MVGDGLSPVLFIIYLEHALKEVRKVIGEPKSPLEEKIPREIAYADDVDFVGLEYIDIDAVQRTLHKYNLKVNVAKTTHSIVNNYGKVLNIYYPTKISNKTLYTKCNEKPLSIHILESRWRLFGHILRRNEEIPANKAMQLYFHRTEKRFRGRPTTTLPVTINKDLSQIQDNLSLKSTDDLEYLRSLAQDRNQWKSLTKQIVEIAEASRSDDQDAKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B150</accession>
    <name>A0A3S1B150_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_014859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000585">
        <property type="protein sequence ID" value="RUS77379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B150"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS77379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="210" mass="22277" checksum="DBD26BCDE4AC53E8" modified="2019-04-10" version="1">MPLACHGDPEREDAQARSGNFHPLVKHSDDPWLGGSFAIDQVQGRLLKFHHRRAVSSPSHSVFRQELCTAAPEVEKSGWLSGAKDLVTQTPARDFSTPGHRSPPLGDVTDRSPPLGDVTDRSAPPGGSSDGFPVWLETIRSRRRQLQQYLRHGAGSVSVSGQGGALRESYLGPVTAAPDWLVSALESGLSLSLSPAADTPGGGQTRAGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B152</accession>
    <name>A0A3S1B152_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_019828</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001071">
        <property type="protein sequence ID" value="RUS72410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B152"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS72410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="135" mass="15183" checksum="861276215B93D93C" modified="2019-04-10" version="1">MKLFKYSFVENRVRFTCIVLFHLSNPLNAISFINNVSIRYPFKSNEDPSLSTSFHALSVIYRNTVAISNSVDAAFASSECNVPTTLDLAYLRYSREVSSAFFNNRSSCQSLSSQILPQCIGIVEPSKEQKKPTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B1J0</accession>
    <name>A0A3S1B1J0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_019527</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="RQTK01001029">
        <property type="protein sequence ID" value="RUS72706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B1J0"/>
    <dbReference type="STRING" id="188477.A0A3S1B1J0"/>
    <dbReference type="OrthoDB" id="20295at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF16">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin conjugation factor E4 core" evidence="6">
        <location>
            <begin position="310"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS72706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="888" mass="102577" checksum="242980397AC87E83" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B2X0</accession>
    <name>A0A3S1B2X0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_013617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000499">
        <property type="protein sequence ID" value="RUS78611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B2X0"/>
    <dbReference type="OrthoDB" id="6241411at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS78611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="30332" checksum="54B74DF574328391" modified="2019-04-10" version="1">MCPGLSDDLQQKFNDEARKRTIINRDLKRLDFDIAALQETSLASSGSPREQDYTFLWQDKEPEEPRINCVGLAIVPTRGFQRLNLGIQLFAVCGTARGMFEGLKKAFDSSQVEIVPLRWASGGISKVAESKWRGGSSITSIIVTDTAVERILPVMDEPDAKPSIEELSKAINTFASGKAPGIDGIPPEVIKAGKKTVLLNHLHNLLLQCWVEGSVPQDMRDANTTTPYKNKEDGSDYNNYRRISLLSILGKIFARVVLIRLQSLAERIYLEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B5B7</accession>
    <name>A0A3S1B5B7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_019895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001078">
        <property type="protein sequence ID" value="RUS72337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B5B7"/>
    <dbReference type="STRING" id="188477.A0A3S1B5B7"/>
    <dbReference type="OrthoDB" id="193650at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028042">
        <property type="entry name" value="DUF4639"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34438:SF1">
        <property type="entry name" value="CHROMOSOME 2 OPEN READING FRAME 81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34438">
        <property type="entry name" value="SI:DKEY-97L20.6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15479">
        <property type="entry name" value="DUF4639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS72337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="479" mass="53567" checksum="030AA65F8048E426" modified="2019-04-10" version="1">MSRQAPSKTRGLDKTKPPASQTPVIAHEIIPGKYNDSDWNLMVDKDGGDDFITDIVDELMQTTMSAIYDKYIQNQLLPFTITQARDALTEIIEWQFLARDEGEEHIECDLGWAQDEEPEPAVTDCWAQGSVPRNFVPTPEVPLEEILEEPEGEEETMEPAVETEVVIEPPEVEDIVSEPDTKQNVETIDEISKDEELKKHQPQEPKQKPRTKFRPYKGKLKSAGVRKMTESLEETEMKMMYNEIAASVSGSDEMPSTLLNMPASCTSILKVQTGRPPGNKDVVYDDYGNVVAVMKLDPEKLPTHKVNVKYHVVDPAVEAAQARLDAMRKGKSTGSKHKKMRSMKSNIAESVTTGKPSIYEAAIMFQPTQSDSSISIYLCKWLCNDTCTHQIEEMEVSHGVIIREGGRVKKGPGRYYRKLDVLEESQKGMTPVTLRISNPGITVADLLDRHTPILRPLSESSPLPPIVPQPPSQNSQQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B5D1</accession>
    <name>A0A3S1B5D1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Set apart in position or space protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_015778</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Integrator subunit 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000660">
        <property type="protein sequence ID" value="RUS76464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B5D1"/>
    <dbReference type="STRING" id="188477.A0A3S1B5D1"/>
    <dbReference type="OrthoDB" id="5844105at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0051642">
        <property type="term" value="P:centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019355">
        <property type="entry name" value="Cell_cycle_regulator_Mat89Bb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12955:SF1">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12955">
        <property type="entry name" value="SARCOMA ANTIGEN NY-SAR-95-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10221">
        <property type="entry name" value="Mat89Bb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS76464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="24588" checksum="6D18524C1E90CFC3" modified="2019-04-10" version="1" fragment="single">MFAVSHKTVFVLDRSPYFAQSCNQPIEYDVLRSKGSGIIPAAPITKSLWTCCIDALQEYLRIVMDIYPREKQVKLTEGISFFTNHPDGKLCKTILTKLSLVGPPKKEDDGFSVLHGLSAAVNCLREPTVQQTWKMESSGQAVKNRGRIILLTHIKNQSQMQKLEAYVQEEITQMNMSDGSDLLPIHECELVVVHSIPLDQEIRLNDRPLRELGPVLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B5X5</accession>
    <name>A0A3S1B5X5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_016505</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000716">
        <property type="protein sequence ID" value="RUS75723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B5X5"/>
    <dbReference type="STRING" id="188477.A0A3S1B5X5"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000287">
        <property type="entry name" value="PR domain zinc finger protein 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="508"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="642"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="884"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="913"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="941"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="969"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="998"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1026"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="46"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="566"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1055"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="566"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="605"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1057"/>
            <end position="1067"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS75723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1085" mass="117133" checksum="7F998926AEFFB76F" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B7S6</accession>
    <name>A0A3S1B7S6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Integral membrane protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_010412</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ITM2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000319">
        <property type="protein sequence ID" value="RUS81820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B7S6"/>
    <dbReference type="STRING" id="188477.A0A3S1B7S6"/>
    <dbReference type="OrthoDB" id="9982095at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001540">
        <property type="term" value="F:amyloid-beta binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042985">
        <property type="term" value="P:negative regulation of amyloid precursor protein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007084">
        <property type="entry name" value="BRICHOS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040145">
        <property type="entry name" value="ITM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10962:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10962">
        <property type="entry name" value="INTEGRAL TRANSMEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04089">
        <property type="entry name" value="BRICHOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018618848" description="Integral membrane protein 2" evidence="10">
        <location>
            <begin position="20"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="BRICHOS" evidence="11">
        <location>
            <begin position="93"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS81820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="238" mass="27230" checksum="A96BDA72D47E7FBA" modified="2019-04-10" version="1">MHMLLALIILGVLALGAIGSIVLYRHLNKKVYTGRCGNEFYDPVFHEGLDTSQAQARTSRSQVLNDYVDEDITVCPEEKYEEIHTPAFDEVRETFIVHDFVSNYTAIIDHEARRCLVRTIRQDIVGPNAFVLQIEEKTPFGLRVSTTVVRQDAIIKTWNYPRPYGKRIAEACFRYDFFTLELYFHGMKKRSPTRRSQKAALGKPVGTYAVFTNNATHQTLYKIRVFEPVASVKPVALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B888</accession>
    <name>A0A3S1B888_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_017813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000832">
        <property type="protein sequence ID" value="RUS74419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B888"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS74419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="205" mass="22577" checksum="20FAE40663FA1E95" modified="2019-04-10" version="1">MELAQPNNKANAKNFIWKIPEDRGSVLTSFKHYDRPEFGRGKHDRSLAITGPVEKTKRIATAATANTAASTADSNTITEPTTDTDTDNTTPHDAASDNAASHDNSVSDNATSNNATLDYATSYDTTSDNNTTYDDNTTYDDNTTYDDNTTYDDNTTYDDNTTYDDNTTSNDNTTYDDNTTYDDNYATTHSATYNHTGTRDERTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B9L8</accession>
    <name>A0A3S1B9L8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 135 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_013820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000511">
        <property type="protein sequence ID" value="RUS78406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B9L8"/>
    <dbReference type="OrthoDB" id="291792at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031926">
        <property type="entry name" value="TMEM135_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF6">
        <property type="entry name" value="GB|AAD46013.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15982">
        <property type="entry name" value="TMEM135_C_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="310"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein 135 N-terminal" evidence="3">
        <location>
            <begin position="250"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS78406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="468" mass="52111" checksum="87665661B96A3BD9" modified="2019-04-10" version="1">MTESNDAQQEQTEKDQTDIESSVCNSTHHQNGNGVVYSNTNKGTTDDIPKCSLSEKECWELATEFAKRFSKGFISGVGVYTGVRIVTALLKNPFRKSLPVIWQDVMSRDCAAVAGFLGLYPSVYHLLLKLLVRYRGRKDGWNYGVAGGVGGLSVALLDSSRRQTLAFFTLSRALGAGISTLVTRGFLNHIPFFEVGVFSACVSLIVHCTAMAPQYLNRGYYMSIIKWSRDYTDERLTRAFREPGPRFLTCAEIGLHEGSCTKHRVTDLLQSLSGFAKLYLPIHLIPVLIFKRGLLLKRPFFVLYSLSKNLALSTAFLGLMVFLAKIVICLLRNALQRPPPLPGFIPAVAGAVCGLALLLERFSRRKELALFVIPHFLNILYVAAEKSPALKPFLRLPHGFTLVFALSMTSVMHAYEREPQSLTMLINGVLRFFFGPSSNSTQNSKTSKTDTVKSDAENERNEEILKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B9N1</accession>
    <name>A0A3S1B9N1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">IGFBP N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_009148</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000259">
        <property type="protein sequence ID" value="RUS83062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B9N1"/>
    <dbReference type="OrthoDB" id="365605at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000867">
        <property type="entry name" value="IGFBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017891">
        <property type="entry name" value="Insulin_GF-bd_Cys-rich_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00219">
        <property type="entry name" value="IGFBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00121">
        <property type="entry name" value="IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00222">
        <property type="entry name" value="IGFBP_N_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51323">
        <property type="entry name" value="IGFBP_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018675226" description="IGFBP N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="IGFBP N-terminal" evidence="3">
        <location>
            <begin position="57"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS83062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="126" mass="13886" checksum="C460E718B62A97FE" modified="2019-04-10" version="1" fragment="single">MAYPASYRAVSLGYLLLACLVICVGGSNQNPGEITGPCMGCRLFNLHHRQHPEHKQDTAFCQYPCQCPIAVIDCKHENRSEVKDGCGCCFMCAKQLSEACSVKDVCDSAKELYCDKRDEKSIGVCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B9R7</accession>
    <name>A0A3S1B9R7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_009082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000256">
        <property type="protein sequence ID" value="RUS83135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS83135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="225" mass="26783" checksum="7DD1FC10F3B5CDA0" modified="2019-04-10" version="1">MTLGAMEKTNRAGWERQGHQLPFEPRTFKLRGLTGLHAPDQLTECNNWEKIHHTVTDVHSRIIYMPKLPYWPYYCKSVHMSLREVRLSFERTEKKKKKKKKKKKKKKKKKKKKKKKKKKKKKXXXXEEEEEEEEEEEEEEEEEEEEEEEEEEEEENMKTMEHRAATTLLQRTRFWDVLLSSAHVIPAALASASVLLRQLRPAALSIPTLESPTVFLLVMIWTIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BBK1</accession>
    <name>A0A3S1BBK1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dyp-type peroxidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_012007</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000403">
        <property type="protein sequence ID" value="RUS80242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BBK1"/>
    <dbReference type="STRING" id="188477.A0A3S1BBK1"/>
    <dbReference type="OrthoDB" id="76259at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048328">
        <property type="entry name" value="Dyp_perox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006314">
        <property type="entry name" value="Dyp_peroxidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01413">
        <property type="entry name" value="Dyp_perox_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30521">
        <property type="entry name" value="DEFERROCHELATASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30521:SF0">
        <property type="entry name" value="DYP-TYPE PEROXIDASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20628">
        <property type="entry name" value="Dyp_perox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dyp-type peroxidase C-terminal" evidence="6">
        <location>
            <begin position="224"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS80242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="387" mass="41743" checksum="A6CB1C303CF5F7A6" modified="2019-04-10" version="1">MASLRSLTFARSAGSLARSLSRSSSTKAGAGLARSRAALLAGSAAVGLTGYGIYKSLSRTTQDDIIATVQAAVPNNTLSAAGPPQSQDSVWSPGKDHALYLWIHLKPGANLKEVSKVCAKLPKMVDTVVDPTMKDEDDEVLAGVGFGPNFYAQVAGKTKKNFVYPHRKGAIGDMPSSGGDVFIHAKSNQVSKLFELASMFLRSLPKDSVESAEDIYSFVYQNGRDLSGFIDGTENRADDEGRQEVAIEKETGGSYVITQKWIHDLDVINSEKSKTLESWVGRDRGDSTELSRKSITSHVARMTGGNGFQQPKPVEIVRQSMPFGTVSGEAGLFFIGYAADPNNFEFMLDRMVGAGGDGHHDDIMRLSKNVKGTYWYFPGAQELAKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BBS0</accession>
    <name>A0A3S1BBS0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH myb-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_011882</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000397">
        <property type="protein sequence ID" value="RUS80343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S1BBS0"/>
    <dbReference type="OrthoDB" id="608866at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070197">
        <property type="term" value="P:meiotic attachment of telomere to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11660">
        <property type="entry name" value="SANT_TRF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042359">
        <property type="entry name" value="TERB1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14014">
        <property type="entry name" value="TELOMERE REPEATS-BINDING BOUQUET FORMATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14014:SF0">
        <property type="entry name" value="TELOMERE REPEATS-BINDING BOUQUET FORMATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="2">
        <location>
            <begin position="1542"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="774"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="999"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1082"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1252"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1323"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="784"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="805"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1002"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1031"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1082"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1123"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1141"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1265"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1291"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1327"/>
            <end position="1343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS80343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1595" mass="178895" checksum="95A42DCD8835D5B9" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BCM2</accession>
    <name>A0A3S1BCM2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_011839</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000393">
        <property type="protein sequence ID" value="RUS80403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BCM2"/>
    <dbReference type="OrthoDB" id="6062171at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018638731" description="C-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="37"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS80403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="223" mass="24848" checksum="1E56E53804F5B173" modified="2019-04-10" version="1">MRFVLVLVMMLLLLWSAGTRAGGTFRFRVLDTIHVPSEGHVRCQETGFDGLAIISSPEAYKHAMAVIQPNASSSTSRFAIGLFLNSAERDFFWADGTEYARDTPWSNYPPDTSGTKPFCRLRADGKILTTKDNNAAFSLCGMYDTRESYGRTLHKQQPDGQTSSLRVQQTRSYLECTVLCGSDYRCRAAEYSFTTSMCTTLGPNMFSGFSANEFTSTFDRGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BFL3</accession>
    <name>A0A3S1BFL3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Progestin and adipoQ receptor family member III</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_009678</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000281">
        <property type="protein sequence ID" value="RUS82548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BFL3"/>
    <dbReference type="STRING" id="188477.A0A3S1BFL3"/>
    <dbReference type="OrthoDB" id="529367at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF15">
        <property type="entry name" value="PROGESTIN AND ADIPOQ RECEPTOR FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS82548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="33312" checksum="F65EC931549AFF65" modified="2019-04-10" version="1" fragment="single">MTSPTYGRFDLVKNRQSKSQQCSHKLRDNAYHIMEIEIDDHSLKACQTGICDREQEAINLLKYHEIPDFLKMPYVLHGYRCRLPPDLCMKSLIFWTNETLNIWSHLLGFFIFLLLVLYDNIIALPQIGGSLADHFIITIGLFCFMFCMLCSTGYHIFYCHSERASKKWLAVDMTGVSIGIIGCYLPAVHYAFYCLSIWRDIYMIIIVLLSMCILGFQLHPRFFTHEWFIVRMMLYVGLVAYGIIPTIHWIYLSGGISAPIVQMFVPKVTMMYMLGGLAFTFYITRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BHB3</accession>
    <name>A0A3S1BHB3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_008617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000236">
        <property type="protein sequence ID" value="RUS83649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BHB3"/>
    <dbReference type="OrthoDB" id="6151748at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS83649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="207" mass="22880" checksum="38D04F9392A06177" modified="2019-04-10" version="1" fragment="single">ARLCYVRPGIISACNVTGAWQKRDSFLERACHSYVTPKAMGGKLYQNVFCFLCNHGDDDAKLQLYLRACQRNVNLGATSSVGDAATHRAGSSQTLSVTLSNFDITQELPQSVLFEGPTNKKCGEREVYDFKQKLCRPVFCAVGQKLVLGRCEPMFLSLSGVAYELYFSLVPQQPVDLSGANDLLHVLPTEMEAYLGSVMLRNTVKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BJK4</accession>
    <name>A0A3S1BJK4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein 26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_002430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000047">
        <property type="protein sequence ID" value="RUS89818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BJK4"/>
    <dbReference type="OrthoDB" id="10042902at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019169">
        <property type="entry name" value="Transmembrane_26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22168">
        <property type="entry name" value="TMEM26 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22168:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09772">
        <property type="entry name" value="Tmem26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS89818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="31486" checksum="68543153982834E2" modified="2019-04-10" version="1" fragment="single">MIGENCFNIIKALVVRFALALHTILTVWRVTENLYDQHYWLLLCLMIPFVAEGIYSVFRRKGKEYLWFSPCFFLYLCATLPPIWLLELDKSRQVREEGDGLNHTERLPVSLNPNMWTIVIEEMLLYLLVIGRWILPRGEITREQLSELLFAFIGIAADVMEFFSLFGENDVRNHEILGYCLLSIWSLSILQFTMAVTVTQQPKRAKKVRLNKYSEPDENDQSKLSSELGAIFISMAMQDVPFLVVRLYTIITYNLITYSLIFFTSKNMLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BKS1</accession>
    <name>A0A3S1BKS1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_001649</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000029">
        <property type="protein sequence ID" value="RUS90561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6159745at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="113"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="194"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="541"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1002"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1086"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1086"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1107"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1142"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1213"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1240"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1263"/>
            <end position="1277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS90561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1298" mass="141118" checksum="5BFE79ABA0A5760C" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BP11</accession>
    <name>A0A3S1BP11_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_020837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001219">
        <property type="protein sequence ID" value="RUS71406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BP11"/>
    <dbReference type="OrthoDB" id="10255512at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="108"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS71406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="240" mass="27064" checksum="1E7B1FE94EAFA857" modified="2019-04-10" version="1">MNAATPLRFTYRPLTFKLCLDMLLSCSKHTIQIVSAQLDDLQHTIKIVSRQLDDPQHTIKIVSGQIDDLQHTTKIVSRQLDDPQHTIKIFSGQLDDLQHTTKIVSAQLDDLQHTIKIVSAQLDDLKHTIKIVSRQLDDLQHTLKIVSAQLDDLKHTTKIVSAQLDDLQHTIKIVSAQLDDLQHTIKKIVSAQLDDLQHTIKIVSLQLDDLPTRPGDMRPPRLAHAFIFGVCCWLSAGHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BP74</accession>
    <name>A0A3S1BP74_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_020695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001199">
        <property type="protein sequence ID" value="RUS71539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BP74"/>
    <dbReference type="OrthoDB" id="10071766at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="196"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS71539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="427" mass="46857" checksum="499AE41E91F8A939" modified="2019-04-10" version="1">MRSFVSQVLSNFSQNALTAPCSAIKSSPTHSHNATFSTSSAGAWPRQQSNVGFGASCLEAGAAAAALISPQSKSFCGVASHREDFTVADATSSSRKSVSFSEAPGSRRALFSDEDNAKVKTLFDNGGGDGSRRAPSEFEDCGPSTHSTATPGFAKIKSIPLTSTVAQRSETDESDGEESSGKHVKMSHLSTQVEALAQLLREITKAVQLVERASDLSIKDGQEELCVVKEQLQHEKRLKLELQAELEKKSESLDATKLSQKDLHRRVSEMTKSLMNFHDQSLQISRLEEEKRDMKWKVADLEGQCSLLSSHLEAVVQKLDAAMVGQSEHQGTSGHEVLALKKEKHELMMKLFAERDFHRDLGDKAVQKMKVLEGNWKKAEDEVRRLDELIEDVREGCVRSQAQSTHPLILDIVRLIDGKLPSLSSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BRH8</accession>
    <name>A0A3S1BRH8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6451 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_019079</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000971">
        <property type="protein sequence ID" value="RUS73157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BRH8"/>
    <dbReference type="STRING" id="188477.A0A3S1BRH8"/>
    <dbReference type="OrthoDB" id="7384832at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045609">
        <property type="entry name" value="DUF6451"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF25">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20049">
        <property type="entry name" value="DUF6451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6451" evidence="2">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS73157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="188" mass="21484" checksum="91DA494FA1900F93" modified="2019-04-10" version="1">MVIDHYFDDTSLLSLLFQKQQYVQEKLYHVAEEAGKTRLQINIRRTAAMRINNKQANALRLHGENIEKVDKFVFLGSVVSKDGGTDEESDAESTRLDTPSSPSNQSGGLQHYRPVRNKIRIFNTNVKSVLLYGSEIWSATKISTTKLQTFTSRCLINIVNLRWPEVVSNKELWGRTKKTLIETEIKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BXD4</accession>
    <name>A0A3S1BXD4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_014869</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000586">
        <property type="protein sequence ID" value="RUS77355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BXD4"/>
    <dbReference type="STRING" id="188477.A0A3S1BXD4"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS77355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="114" mass="12580" checksum="04DA841ADDFED20D" modified="2019-04-10" version="1">MPEDIENYVHRIGRTGRKGQKGVATTFVNKSVEESILLDLKHLLIEANQKVPAFLATLESETEKYLDISGEVGCSYCGGLGHRIADCPKLQAMQTKQAQGIGRKDYLANNSADW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C1C5</accession>
    <name>A0A3S1C1C5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Asparaginase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_011960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Ntn-hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000401">
        <property type="protein sequence ID" value="RUS80276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C1C5"/>
    <dbReference type="STRING" id="188477.A0A3S1C1C5"/>
    <dbReference type="OrthoDB" id="2262349at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033345">
        <property type="term" value="P:L-asparagine catabolic process via L-aspartate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.30">
        <property type="entry name" value="(Glycosyl)asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188:SF43">
        <property type="entry name" value="ASPARAGINASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="3">
        <location>
            <begin position="191"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS80276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="23637" checksum="5F3D60A0F41B5E92" modified="2019-04-10" version="1" fragment="single">MYRPAIIVHGGAWAIPEELTTRSLHGVKAAVSKGHQVMVTGGSALDAVVAAVSVLEDDTAFDAGVVLDNDNNNNNNNNNNNNNNHGAVLNLHGEVELDAIVVDGRTMDSGAVCGLQGCAHPVQLARLVMDKTNHCLIAGRGANEFMQKEGVASVPDTELVTPEARKEWETFMNFSSTVKTLSAPPRQSGCDTVGAVAMDANGNLAAATSTGGITAKLPGRVGDSPIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C4J2</accession>
    <name>A0A3S1C4J2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_009444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000271">
        <property type="protein sequence ID" value="RUS82780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C4J2"/>
    <dbReference type="STRING" id="188477.A0A3S1C4J2"/>
    <dbReference type="OrthoDB" id="10263316at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032707">
        <property type="entry name" value="MYCBPAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48421">
        <property type="entry name" value="MYCBP-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48421:SF1">
        <property type="entry name" value="MYCBP-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14646">
        <property type="entry name" value="MYCBPAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="878"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="878"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="922"/>
            <end position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS82780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1071" mass="121469" checksum="E1C0277BA81FFA36" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1CAY9</accession>
    <name>A0A3S1CAY9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL49</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">39S ribosomal protein L49, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_004407</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL49 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000100">
        <property type="protein sequence ID" value="RUS87808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1CAY9"/>
    <dbReference type="STRING" id="188477.A0A3S1CAY9"/>
    <dbReference type="OrthoDB" id="19439at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000009">
        <property type="entry name" value="39S ribosomal protein L49, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007740">
        <property type="entry name" value="Ribosomal_mL49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477">
        <property type="entry name" value="MITOCHONDRIAL 39S RIBOSOMAL PROTEIN L49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05046">
        <property type="entry name" value="Img2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS87808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="213" mass="24479" checksum="1BFF374A8F7C9AD3" modified="2019-04-10" version="1">MAALSGTTFLRIYHRVLPVFINATRSKPVIATSKYKKCILHHKLANDKVSVCGLLSVRQHSTSFSASQDELDQNDLIKDFEVSHEEFKYVEQILPSPTVPELEEQTQYPTPSGWFPPDEATQAQQKYLIRRTKNHMLPVYSHTQNTWFGTSHFVSIKKIEGDIWALEADLREHVLKTTGQKSVNTHVHEVGRFIRVRGQHRDLIAKFLLEKGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1GYR0</accession>
    <name>A0A3S1GYR0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_023415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001990">
        <property type="protein sequence ID" value="RUS68824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1GYR0"/>
    <dbReference type="STRING" id="188477.A0A3S1GYR0"/>
    <dbReference type="OrthoDB" id="6158937at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050166">
        <property type="entry name" value="ABC_transporter_ATP-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42788:SF13">
        <property type="entry name" value="ALIPHATIC SULFONATES IMPORT ATP-BINDING PROTEIN SSUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42788">
        <property type="entry name" value="TAURINE IMPORT ATP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS68824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="144" mass="15786" checksum="7DB459B94B061251" modified="2019-04-10" version="1" fragment="single">MDNIDFTLHEGEIVALLGKSGSGKSTLLRIIAGLLSPSSGEVIYRGKKVSAPVPDISMVFQSFALMPWLTVLQNVELGLEARKIEKRQVRRRALKAIDMVGLDGFENAYPKELSGGMKQRVGFARALVLEPDVLLMDEPFSALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1GZ65</accession>
    <name>A0A3S1GZ65_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GPR158/179 extracellular domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_023164</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001845">
        <property type="protein sequence ID" value="RUS69071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1GZ65"/>
    <dbReference type="STRING" id="188477.A0A3S1GZ65"/>
    <dbReference type="OrthoDB" id="9970547at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18773">
        <property type="entry name" value="PDC1_HK_sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043458">
        <property type="entry name" value="GPR158/179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054714">
        <property type="entry name" value="GPR158_179_extracellular"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32546">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 158-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32546:SF26">
        <property type="entry name" value="SMOG, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22572">
        <property type="entry name" value="GPR158_179_EC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="GPR158/179 extracellular" evidence="9">
        <location>
            <begin position="29"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS69071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="103" mass="11838" checksum="C519EE5057C0F064" modified="2019-04-10" version="1" fragment="single">RSNTNGTSSIRHEFFPITYRAAPYEVGFWTKPHFRCDGKVDAWVMTYVSPFFGLDSLRTKLEFRGVTTVDVPLSFLELNQCPMPYSVPNAFKNTARCDYLSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H260</accession>
    <name>A0A3S1H260_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_021526</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001349">
        <property type="protein sequence ID" value="RUS70714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H260"/>
    <dbReference type="STRING" id="188477.A0A3S1H260"/>
    <dbReference type="OrthoDB" id="6159232at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052391">
        <property type="entry name" value="E3_Ligase-Neurotoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24133">
        <property type="entry name" value="ANKYRIN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24133:SF40">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="75"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="110"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="143"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="176"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="351"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="452"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="590"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="452"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="591"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS70714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="615" mass="65863" checksum="1CF289A122EDB1F9" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H2C0</accession>
    <name>A0A3S1H2C0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Armadillo repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_021445</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with mitochondrial contact site and cristae organizing system (MICOS) complex components IMMT/MIC60 and MICOS10/MIC10. Interacts with mitochondrial outer membrane sorting assembly machinery (SAM) complex components SAMM50 and MTX1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001332">
        <property type="protein sequence ID" value="RUS70797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H2C0"/>
    <dbReference type="STRING" id="188477.A0A3S1H2C0"/>
    <dbReference type="OrthoDB" id="17335at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016617">
        <property type="entry name" value="ARMC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46840">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46840:SF2">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS70797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="282" mass="31235" checksum="C430F82314717607" modified="2019-04-10" version="1">MATTDAIAAMKQMASDPKKRVLLVKDQTCVGGLIIVLSNADSAVVREALLTLLLLSECPEARTVLRNQVGMTDQLDKLTNTTDKDSELFQLSEKLKAKLTITKEEAQKVPLKDCSNVSSRRNSNARNQSLQGHRVKTIVLLLRGYQDKSDRDLCARLLLKVKGVISITFDLSKLRCIVRTKPEVKAEALAASIAKSMTMTAQQVVRNENGEESFVTFGSSRSCDPNTSYAKENEDLPDYLSDDSDSILVDDKALKRPSDEDKKKSTSWFSAAASFLSNSFYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HVL5</accession>
    <name>A0A3S1HVL5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_005280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ATG8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000123">
        <property type="protein sequence ID" value="RUS86955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HVL5"/>
    <dbReference type="STRING" id="188477.A0A3S1HVL5"/>
    <dbReference type="OrthoDB" id="6738456at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10969">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS86955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="12908" checksum="2FD5C42154760535" modified="2019-04-10" version="1">MKGGARSLRTPCLSLREEKEGKHGVIVSKNPLSDIYDIDKTHYLVPGAMTVAQFIYIIRQHIQWPVERPLFLFVGRAVHVPAATFTIGEVYQEYKNEDGFLHVVYSGENAFYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SKP7</accession>
    <name>A0A433SKP7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_022542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001602">
        <property type="protein sequence ID" value="RUS69697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SKP7"/>
    <dbReference type="STRING" id="188477.A0A433SKP7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS69697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="110" mass="12929" checksum="0146FBAE78EB5B86" modified="2019-05-08" version="1" fragment="single">RSYSNVYSHTTRDSRSYSNVYSHTTRDSRSNSNVYSHTTRDSRSYSNVYSHTTRDSRSYSNVYSHTTRDSRSYSNVYSHTTRDSRSNSNVYSHTTRDSRSYSNVYTQPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SKT3</accession>
    <name>A0A433SKT3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_022491</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001587">
        <property type="protein sequence ID" value="RUS69743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="188477.A0A433SKT3"/>
    <dbReference type="OrthoDB" id="2286242at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000004">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF7">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="7">
        <location>
            <begin position="45"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase zinc-binding" evidence="8">
        <location>
            <begin position="271"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="52376" checksum="10A28C17F4A7E729" modified="2019-05-08" version="1">MASYLIRLSSNLQKTTVEFAGPEITPTTKHCFCPSVKPFCCKTGWRITLVGSRFTTGAESRYAPIEGEALAVVDILDKARYFTLGCSDLIVAVDHKTLLNTFGDRCLDDLPNPRLRNLKEKALRYRFKVVHIPGIHLAAADAMFVKPVSEPCMLTLPDDVAALLPFIIPSIEPCLPQTFLQTICTHFQDDSTKVCSQTDSTPTELVKSETWDNVSLATASDPIMMALSKTIEDGFPYDRTHLPPEIREFYQFRENLSTFDGVILYHDRVVVPPSLRDKIIQTLHSAHQGVSQMLSRAETSLFWPGMTPAITETRARCSSCNRMAHSQPSAPPTPPVSPAFPFQCIVADYFHYRGHNYLVVVDRYSNWSIVEEASNGAAGLIAALRRIFVTYGISDELSSDGGPEFTSLLRNWGVTHRRSSVAFPHSNCRAEVRVKTAKRLITDNTDTHGSLNTDKFQQVYSGGVSTYGTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SN96</accession>
    <name>A0A433SN96_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_021629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001370">
        <property type="protein sequence ID" value="RUS70609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="6084966at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1019"/>
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        </location>
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        <location>
            <begin position="1100"/>
            <end position="1123"/>
        </location>
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        <location>
            <begin position="1177"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1264"/>
            <end position="1287"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="1363"/>
        </location>
    </feature>
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            <end position="1482"/>
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        <location>
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    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS70609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1518" mass="170392" checksum="F393720916811E55" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SNY3</accession>
    <name>A0A433SNY3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_021337</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Lophotrochozoa</taxon>
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            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
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            <taxon>Placobranchoidea</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001308">
        <property type="protein sequence ID" value="RUS70909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14312">
        <property type="entry name" value="CREB/ATF BZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <end position="107"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="2">
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        </location>
    </feature>
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        </location>
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        </location>
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        <location>
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        </location>
    </feature>
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        </location>
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    </feature>
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        <location>
            <begin position="221"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="763"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1075"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1386"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1449"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1569"/>
            <end position="1594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1890"/>
            <end position="1901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1909"/>
            <end position="1921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1954"/>
            <end position="1964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1972"/>
            <end position="1986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1989"/>
            <end position="1999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2000"/>
            <end position="2010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="2076"/>
            <end position="2085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2096"/>
            <end position="2122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="2132"/>
            <end position="2145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2977"/>
            <end position="2988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="3043"/>
            <end position="3059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="3060"/>
            <end position="3069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="3087"/>
            <end position="3096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="3209"/>
            <end position="3219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="3291"/>
            <end position="3303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS70909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="3303" mass="365817" checksum="6C3E367CC55B6975" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SP69</accession>
    <name>A0A433SP69_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_021195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001281">
        <property type="protein sequence ID" value="RUS71049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SP69"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS71049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="174" mass="19918" checksum="FEF7421004B1587D" modified="2019-05-08" version="1" fragment="single">VFSLLNFKCTGVLFGTQVYCLPCITSAMFTIHYKCIVYYALQVQCLPCITSVLFTMHYKCNVYHTLQVQCLPHITSAMFTTHYKCNVYLALQVQCLPCITSAMFTTHYKCNVYLALQVQCLPCITSAMFPTHYKCNVYHTLQVQCLPCMTSAMFTIHYKCNVYLALQVQCLPCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SR75</accession>
    <name>A0A433SR75_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycolipid transfer protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_020474</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GLTP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001163">
        <property type="protein sequence ID" value="RUS71760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SR75"/>
    <dbReference type="STRING" id="188477.A0A433SR75"/>
    <dbReference type="OrthoDB" id="116883at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902387">
        <property type="term" value="F:ceramide 1-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902388">
        <property type="term" value="F:ceramide 1-phosphate transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032691">
        <property type="term" value="P:negative regulation of interleukin-1 beta production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3520.10:FF:000002">
        <property type="entry name" value="Ceramide-1-phosphate transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF43">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Glycolipid transfer protein" evidence="4">
        <location>
            <begin position="184"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS71760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="365" mass="42197" checksum="54ABDD99D7C507A4" modified="2019-05-08" version="1">MVTAGRLTTVAATLSPLCLTTRRMKFVFLALTVSLLLLVLGILTNRDSPTDVDHNSWRRSIDKHTPLEKLQVQKFRKSKLSLYRDRRRSTFAKRKHQDEDSPTSRSKFAKRKHQDGERQSVSYKNLLPTQTKVKMETPATPETDQQFTTGSSIGDGMAAHEHFDAEKVYNLFCSCRKEDDVLLLDCYVNAYEELCKLFRHFGTVFSFVTSDVEEKIGILRDYRKSENAEQYKTIQSMLAYEVASETVKKKKKDSGSRTLLRLHRALEFITEFLLKLRESDNHCKFSNVVTKAYDDTLAKHHPWLVKKAVHVAMYMLPSRPDLLKKMGLKDEEKDMSVVMDLVKELNLIYKTTQDLYAKDKLLDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SRH1</accession>
    <name>A0A433SRH1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">[RNA-polymerase]-subunit kinase</fullName>
            <ecNumber evidence="1">2.7.11.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_020395</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.23" evidence="1"/>
    <dbReference type="EMBL" id="RQTK01001151">
        <property type="protein sequence ID" value="RUS71848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SRH1"/>
    <dbReference type="STRING" id="188477.A0A433SRH1"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070985">
        <property type="term" value="C:transcription factor TFIIK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF0">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS71848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="144" mass="16126" checksum="7EAE1446E47C0F7D" modified="2019-05-08" version="1" fragment="single">IISVRLNQAPFLPGDTDLDQLNRIFQVLGTPTEADWPDMKCLPDYVTFKEFPRHPMKEIFTAASDDLLDVLDMTLAINPAKRCSASQALQMSYFSSKPAPTPGSQLPFPKSNKIVDKEKEAKRVSLKRKQNGNDAGGMKKRLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SSX8</accession>
    <name>A0A433SSX8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_019988</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001092">
        <property type="protein sequence ID" value="RUS72247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SSX8"/>
    <dbReference type="STRING" id="188477.A0A433SSX8"/>
    <dbReference type="OrthoDB" id="10266080at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11500:FF:000004">
        <property type="entry name" value="DENN domain-containing protein 2C isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051942">
        <property type="entry name" value="DENN_domain_containing_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15288">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15288:SF0">
        <property type="entry name" value="UDENN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03455">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="2">
        <location>
            <begin position="807"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="689"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="465"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="541"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS72247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1260" mass="139249" checksum="20E11A0718D97541" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433STL1</accession>
    <name>A0A433STL1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_019630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001043">
        <property type="protein sequence ID" value="RUS72612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433STL1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS72612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="205" mass="22758" checksum="3AFBE4669BE903DA" modified="2019-05-08" version="1">MRYWDSPALGRTSLYELVCVQPGAGSNRLVMPMSCTELLQCLWWGQTRSPGRSTAMTCRVQGHKVSFDTTVLLDFRLGDSPVCGHYCLKIGGFQVLEYIGLSECGFFNGQDIETKRALSYKALPCDVPMFSVYVVGWVMIAHAPAWIYGQPSKHSYKHGFRDLASVSPQPRILGGRDQKTEKSEGGNPTFQGFHCKYCGAGDLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SWP9</accession>
    <name>A0A433SWP9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_018506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000906">
        <property type="protein sequence ID" value="RUS73726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SWP9"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS73726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="592" mass="66795" checksum="1BD1F40ADB60146D" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SYZ1</accession>
    <name>A0A433SYZ1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_017719</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLA2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000824">
        <property type="protein sequence ID" value="RUS74512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SYZ1"/>
    <dbReference type="STRING" id="188477.A0A433SYZ1"/>
    <dbReference type="OrthoDB" id="6119533at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043325">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17006">
        <property type="entry name" value="ANTH_N_HIP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1700:FF:000002">
        <property type="entry name" value="Huntingtin interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000012">
        <property type="entry name" value="Huntingtin interacting protein 1-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030224">
        <property type="entry name" value="Sla2_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407">
        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407:SF15">
        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="8">
        <location>
            <begin position="21"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="340"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="446"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS74512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="499" mass="57455" checksum="D6480506D1623452" modified="2019-05-08" version="1" fragment="single">MSSIHLPKSVSQRGKTSLEIDRENFEKRQTVALNKAINSQETPVKEKHARNAILGTFQDQGGNMFWTIASKMPVQANPIVCWKFLQMVHKIMRDGHANVVRHSIRYQAQIHDLGKLWGHLKEGYGKLISSYCKLVVQKLKFHDKFRGIPGNLMMTDEQYYKICGADVNNYFEFSIDMLDYMDDILTLQHAVFGSLDMSRANSMTSSGQCRLAPLILCILDSCQLYDYLVKSLFHLHSSLPPDTLFGHRDRFLVCYKKLKDFYHKCSNLQYFKHLVQVPHLPDDPPNFLIASDFTKHIKPAAIVKEEEPEPEAEADDSVDNLIDMSLPEAAAEPPPPVPEVDERDFLIERLQREIRLLKEELGRVRAEDHRIITGLKEDISKLEKILSELRLSADKSFKENEELKKNLDPLKTDAESAEKLAKANQEKFQKMKDIYSKLRDEHVVLLRNHDTNAKQLSALKKSLEEKDQVLKESQLEVNRMVEEKQMVQENLQKSADDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SZN4</accession>
    <name>A0A433SZN4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Plastocyanin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_017469</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000801">
        <property type="protein sequence ID" value="RUS74771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SZN4"/>
    <dbReference type="STRING" id="188477.A0A433SZN4"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13858">
        <property type="entry name" value="CuRO_1_tcLCC2_insect_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13884">
        <property type="entry name" value="CuRO_2_tcLCC_insect_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000031">
        <property type="entry name" value="Laccase-2 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF394">
        <property type="entry name" value="FI03373P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="64"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="193"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="399"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS74771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="430" mass="48642" checksum="C9251770A92B59A7" modified="2019-05-08" version="1" fragment="single">MTLLSSLTSFSKSADYRSHPCNRQCEDQTSPRLCQYKWVVESYWTLPKACLNCPFNQSDCSRPHCIATDGVQRGIIAVNRRLPGPAVEVCEGDTIEVKIHNELYNSEGTSVHWHGLLQKGTPHMDGVSLITQCPITARSSFTYRFKALDPGTHYWHGHAGMQRADGMFGAIVVRQPPSREPHFARYDYDLSEHVIIVNDWLTRMTLPAFLDHHHDDGDNKPALMLINGMGAHQEFKDGNSTFYTPRASFTVQGGKKYRFRVISAAILNCPIQISVDGHTMMVIASDGSPFEPFVADSFNIFAGERYDFVLVADKTTTLSVLELMYDNFARNKKEPDRAYQYFCLIIIYFVCSFVFNWPFNWTPPSLPAGMWLLHCHIEYHVDIGMGILIQVGDKSEFPKPPKNFPKCGSWNDVDADDDDDDDVGDTSDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T0M4</accession>
    <name>A0A433T0M4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription cofactor vestigial-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_017134</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000771">
        <property type="protein sequence ID" value="RUS75103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T0M4"/>
    <dbReference type="OrthoDB" id="10069705at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011520">
        <property type="entry name" value="Vg_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15950:SF15">
        <property type="entry name" value="PROTEIN VESTIGIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15950">
        <property type="entry name" value="TRANSCRIPTION COFACTOR VESTIGIAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07545">
        <property type="entry name" value="Vg_Tdu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS75103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="22322" checksum="3A605E969CCA180B" modified="2019-05-08" version="1">MKYPSQPLYDTGIPGPGPSNFLEPVSHPHTISHTGSHTGTHTQHHNSHTVPDKDLAGGENKAGPQPKATHYLASNCVLLTYFQGEAASLVDDHFTRSLGQPSSFTLDKPAPANKPYVRSASFTYRLRFRFGLLNRKISALGGILQPPRQHGPGSTCQCFVCPSGVVRFSDGEQTWVMTADLNSNACCFTRHRLSRPRRVNVDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T218</accession>
    <name>A0A433T218_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Malate dehydrogenase, cytoplasmic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_016625</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000725">
        <property type="protein sequence ID" value="RUS75599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T218"/>
    <dbReference type="STRING" id="188477.A0A433T218"/>
    <dbReference type="OrthoDB" id="4069699at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016615">
        <property type="term" value="F:malate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010945">
        <property type="entry name" value="Malate_DH_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23382">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="5">
        <location>
            <begin position="6"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="88"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="93"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS75599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="212" mass="23519" checksum="01B39BBC0AB1CC7B" modified="2019-05-08" version="1">MTCNPRLVRKYSCTSSMDHAFTDADVIFLASGTLPSHGLSRNDIIGTNALEHKEIGQAINRVAKLTVRIVVIMDPQNINLAVLRTSTWQSSGNDDDDDDNNDDDGDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDHTAKRKKHKSHTHLTTAVAAVQHARDWLTGTKPGNWTSMIVISDGSYGVEKGGFCFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T3R2</accession>
    <name>A0A433T3R2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Peptidase M12B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_016059</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000682">
        <property type="protein sequence ID" value="RUS76181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A433T3R2"/>
    <dbReference type="OrthoDB" id="5951731at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04269">
        <property type="entry name" value="ZnMc_adamalysin_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000002">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.70.10:FF:000001">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006586">
        <property type="entry name" value="ADAM_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034027">
        <property type="entry name" value="Reprolysin_adamalysin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF159">
        <property type="entry name" value="ADAM METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08516">
        <property type="entry name" value="ADAM_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00608">
        <property type="entry name" value="ACR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="597"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="13">
        <location>
            <begin position="56"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="12">
        <location>
            <begin position="259"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="496"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="538"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="646"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="697"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="816"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="920"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="540"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="574"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="715"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="741"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="758"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="956"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="989"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1027"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1059"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1072"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1093"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1109"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1127"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1176"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1206"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1299"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="210"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="500"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS76181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1316" mass="141068" checksum="E4BE1F3673C9C4CB" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T592</accession>
    <name>A0A433T592_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_015535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000642">
        <property type="protein sequence ID" value="RUS76708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T592"/>
    <dbReference type="STRING" id="188477.A0A433T592"/>
    <dbReference type="OrthoDB" id="6143825at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="186"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS76708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="314" mass="34261" checksum="1568AA0E7100B8E7" modified="2019-05-08" version="1">MERRCFGPMFLRGPRGIRKSGQSLNCHGPHAADSKECPKWKEEEAIQRYKAQHGGTFAQARAAIVVELDPNIKRRTYAKATSVGTKIAQTAPPKGSGRVNSTVKAQGAKSHKADSPVKKSTVTAESRSTVKPRPSPAPQRAPLATINRFTALTDIEEVTVERRGTGKKPAGLAGHPTDGLPGSKKVSLQKLIDQLPRPFVLLGDFNAHSPTWGDPKLDERGALVENLAQEIDLIILNHKKITFVHSAHHIKSAIDLAVTSASIALDYEWAVHSDLCGSDHFPIFLTFRGNDSTSDDPNVFNYSKADWNSAREHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T5H7</accession>
    <name>A0A433T5H7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">acylglycerol lipase</fullName>
            <ecNumber evidence="2">3.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_015437</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol. Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids. Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism. BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formation of intraluminal vesicles and in lipid sorting.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1-dodecanoylglycerol + H2O = dodecanoate + glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44316"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:18262"/>
            <dbReference type="ChEBI" id="CHEBI:75539"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes glycerol monoesters of long-chain fatty acids.</text>
            <dbReference type="EC" id="3.1.1.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Late endosome membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lysosome membrane</location>
            <topology evidence="4">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Mitochondrion membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.23" evidence="2"/>
    <dbReference type="EMBL" id="RQTK01000635">
        <property type="protein sequence ID" value="RUS76791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T5H7"/>
    <dbReference type="STRING" id="188477.A0A433T5H7"/>
    <dbReference type="OrthoDB" id="428974at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF5">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE ABHD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="9">
        <location>
            <begin position="274"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="200"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="518"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="250"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="530"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="546"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS76791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="572" mass="63543" checksum="37DC0A812D46A304" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T884</accession>
    <name>A0A433T884_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_014447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000552">
        <property type="protein sequence ID" value="RUS77783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T884"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS77783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="143" mass="16657" checksum="294D865B92CE783A" modified="2019-05-08" version="1" fragment="single">MIEMQVMGIRRNTRTASTLVTTSKDQRSSKRPRSATLLNIPRYPRTRRLSRKAKLSGTRQKGKNLTNGKTLFHPKRRIKTILRILTTKSWEWKGSVQPICWNSPNSRPRLEHVTSCLHIERFFLRKTRKVANLPVANKIKTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T8W1</accession>
    <name>A0A433T8W1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_014285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000540">
        <property type="protein sequence ID" value="RUS77976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T8W1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS77976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="365" mass="38724" checksum="7981E40C1A5E07C0" modified="2019-05-08" version="1" fragment="single">MHSPLYLHTATANQNDTIQIATSLSMPKEHSEGVPLLAKSAPSTGNNLSLSTSIMKANKNVYVTTKDIGPFSSTPLKTVNISSKELNPAVSKSAYVPILPQPATFNTIGNTGQLILQNSCLQMIHPNGSVQTIAFLHPSLHSNPAPLSKSDTQPLANTLGNLVNAGNDQQINSSFTVTPSQARTPLSGLLSSCSNSVSCDSVIYSKPSISDCKPGTSTANETHKTMLATVIAGPPRLNTSHNCRPIVTSTAASPPSLSLQYLARLLAPKKVPESEGISSLDIQKKQGKKVTEAEAGSKQFVSGELMVKTNCNDAGKINQCPSLLYKSFQFDQSEGTAGFPSEISYQNQNINKTTSFNKESSPPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T9S0</accession>
    <name>A0A433T9S0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_013931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000519">
        <property type="protein sequence ID" value="RUS78296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T9S0"/>
    <dbReference type="OrthoDB" id="6110468at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS78296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="321" mass="35271" checksum="DF90BE49BAB2AF7A" modified="2019-05-08" version="1">MTVGQPMPAYPGHGGRATPHGGPRVKSEGEPNYVRNQGTVKQKVFDDKAPIVRTPKPSPRCPTSASKQNYKQGWFGNISPMLNGTASPRPNTAPPRVKSEAEAAASLGRGPRMKIIVNEYARSRPTPRQARVKPEAEGTAHVSKGGRMNNLLHKYGTLPMSARAVPRLKLEAEPIAQHSRGWMMNDTLHKYGRNRASPRPEPRVKPEAEDNAELGKGRRMCIIMHKYATGPMSARAPPRVTDAGESNANLDRGVRMSRLLHNPMSMPGSPRPLPRTNTSQAQENAFKGRGSVDKIFNNMAKKTFIYVPGQQAKMYTRASIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TKL3</accession>
    <name>A0A433TKL3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_010192</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000307">
        <property type="protein sequence ID" value="RUS82036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TKL3"/>
    <dbReference type="OrthoDB" id="6098013at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="23"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="141"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS82036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="272" mass="31880" checksum="2064A2C50970D21F" modified="2019-05-08" version="1" fragment="single">VSLLADQASSNLPDQVEELSRARKEHASATASLQASLDELEEKLAKVKEFNQGLANQKKRLITDMCIKECDRDEAKQRITDLKKELEEAAEESVFLTSQIKQKKMEKEKSDKTYKEYVQKMEVYKQSVDKFEQGLPDMTELDMAKKKLKALEEERDEVQRDLNLLSGSREDCWDDVMNDIRRNIQDLESNVKKRNVHVEKLEGKLHDRQREKNKLETANMILKNRNSALLIRLKRQLEIQKKKFAHLTNHIDITEERLKSSKDRLEKLTQDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TMV4</accession>
    <name>A0A433TMV4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_009390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000268">
        <property type="protein sequence ID" value="RUS82868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TMV4"/>
    <dbReference type="STRING" id="188477.A0A433TMV4"/>
    <dbReference type="OrthoDB" id="78308at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044782">
        <property type="term" value="P:cilium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24110">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 78 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24110:SF3">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 78 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS82868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="85" mass="9717" checksum="ADA51A6E49925527" modified="2019-05-08" version="1" fragment="single">MMESVQARQRGAFEFESHYENLCALQDSAPLPAVTAHLSQALLDLNGDRVRLNDWQPIINTLRINKSLQLVALRSYYQMPQEEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TN30</accession>
    <name>A0A433TN30_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="15">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EGW08_009329</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">EC2010</strain>
            <tissue evidence="17">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Sarcoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="15"/>
    <dbReference type="EMBL" id="RQTK01000266">
        <property type="protein sequence ID" value="RUS82906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TN30"/>
    <dbReference type="STRING" id="188477.A0A433TN30"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033017">
        <property type="term" value="C:sarcoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02083">
        <property type="entry name" value="P-type_ATPase_SERCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000055">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000003">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000005">
        <property type="entry name" value="Calcium-transporting ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000065">
        <property type="entry name" value="Sarcoplasmic/endoplasmic reticulum calcium ATPase 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000160">
        <property type="entry name" value="Sarcoplasmic/endoplasmic reticulum calcium ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005782">
        <property type="entry name" value="P-type_ATPase_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01116">
        <property type="entry name" value="ATPase-IIA1_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 15" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0703">Sarcoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="292"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="760"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="833"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="932"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="16">
        <location>
            <begin position="3"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RUS82906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="999" mass="110228" checksum="6C3BDE31A0BF257C" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TRT1</accession>
    <name>A0A433TRT1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U6 snRNA phosphodiesterase</fullName>
            <ecNumber evidence="6">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_008063</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3'-end uridylyl-uridine-RNA = a 3'-end 2',3'-cyclophospho-uridine-RNA + uridine</text>
            <dbReference type="Rhea" id="RHEA:46052"/>
            <dbReference type="Rhea" id="RHEA-COMP:17384"/>
            <dbReference type="Rhea" id="RHEA-COMP:17385"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:85643"/>
            <dbReference type="ChEBI" id="CHEBI:85644"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:46053"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the 2H phosphoesterase superfamily. USB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="6"/>
    <dbReference type="EMBL" id="RQTK01000215">
        <property type="protein sequence ID" value="RUS84176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TRT1"/>
    <dbReference type="STRING" id="188477.A0A433TRT1"/>
    <dbReference type="OrthoDB" id="49151at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990838">
        <property type="term" value="F:poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034477">
        <property type="term" value="P:U6 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03040">
        <property type="entry name" value="USB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027521">
        <property type="entry name" value="Usb1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13522">
        <property type="entry name" value="U6 SNRNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13522:SF3">
        <property type="entry name" value="U6 SNRNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09749">
        <property type="entry name" value="HVSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS84176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="332" mass="37592" checksum="9B9BDC9AE490C414" modified="2019-05-08" version="1">MSCLVSYSGSSDEDGDENPYLESHCSKINLRLSDPSQEKVISATNKYCDSLPLSSKDICNEETGGKLMKGVEPKLTRPSKCVPEKRVDAELSRKRKLAFSEKESLNLPTSIQNMYENKHHVPADNPAMHQNRVRSFPHEVGNWATYVYIPVRKDERLLSFVQNVTEQLLPQGFEILPEFHVSLSRTVAIRHHWIEPLVDSLKDKLQDISTSVCEIVDVKLFTNDEKTRTFVCLELADDDTELLKYVEAVDSSFKDFRLAPYYENPSFHISVGWCLGDIVSNVSRQDLSKAKDMLSEFVAAHPDLSIVYAHEIICRSGNKSFGIKLKESFKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TVY1</accession>
    <name>A0A433TVY1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_006520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000161">
        <property type="protein sequence ID" value="RUS85726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TVY1"/>
    <dbReference type="OrthoDB" id="6152893at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS85726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="474" mass="54332" checksum="5C5AE86A77A10142" modified="2019-05-08" version="1">MARRDSIALYTSSKGVQWRRFSEPFTSKTVGDDKVFAKYDAETPTAFRRYSFSALEDYRKGKLPVKYHQDSVAFSSSGNLTPSAIRGQVDQILESNGFTETERAKVSHLRRCSENIDQNVVNLLGDGVRRSSFGAGASSGTYSVDYQTVKNNKNETEKKGNTRRTGHTVMHDSVYNDQDRLVRTNAWENFKYPPSSARSLIKDNQRKKQDDDGNERKSSETKNIDEHLKLKRSLWNGKCRRDSLSKFRNRIVDDLRAHVETDTEYWRRCRSVNHDGETPKAPKCKYRLRENGLIASDLAYLTKIDIDTTANKLDSYGLYDSSKDHLRSTPECTTSNKAEILRNLLKRRRKSSLFSEYDFDRKSLIQRSLSSFSDRNSRSDSPDFSPSQPLFYQRSISRQVSKTKDGLDSEAYLAYLRANLRKSSCEKRRWSQTPSEGFELIGSEALHGSPGYKGRLMLLTARTVRFNDEFISGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TZI1</accession>
    <name>A0A433TZI1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_005367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000125">
        <property type="protein sequence ID" value="RUS86888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TZI1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS86888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="113" mass="12164" checksum="40A127817315E502" modified="2019-05-08" version="1" fragment="single">QVSQGGDLVLQTRHLGLLHPLGGAQLVNDFPCLGQLVLVRVSDWLQVLRLPVAQSLVLSLQLLDLGIQEVDLLDVGGQTLVQVLHLALLLLAVSLEIGDSRRAELLVDAWAHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TZV3</accession>
    <name>A0A433TZV3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ADP-ribosylation factor 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_005109</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000119">
        <property type="protein sequence ID" value="RUS87109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TZV3"/>
    <dbReference type="STRING" id="188477.A0A433TZV3"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04149">
        <property type="entry name" value="Arf6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000286">
        <property type="entry name" value="ADP-ribosylation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041838">
        <property type="entry name" value="Arf6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="20"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="122"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS87109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="175" mass="20017" checksum="6266F8059A976DCA" modified="2019-05-08" version="1">MGKLLSKLFGNKEMRILMLGLDAAGKTTLLYKMKLGQSVTTIPTVGFNVETVTYKSVKFNVWDVGGQDKIRPLWRHYYTGTQGLIFVVDCADRDRLDEARQELHRIINDREMRDAIILVFANKQDLPDAMKPHEVQEKLGLTRIRDRNWYVQPSCATSGDGLFEGLTWLTSNHKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U1M4</accession>
    <name>A0A433U1M4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_004490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000102">
        <property type="protein sequence ID" value="RUS87744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U1M4"/>
    <dbReference type="STRING" id="188477.A0A433U1M4"/>
    <dbReference type="OrthoDB" id="412155at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051560">
        <property type="entry name" value="MAM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282">
        <property type="entry name" value="APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282:SF101">
        <property type="entry name" value="MAM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAM" evidence="5">
        <location>
            <begin position="13"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="5">
        <location>
            <begin position="176"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="374"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="342"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="411"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="425"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS87744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="460" mass="51487" checksum="84FBE8A79766E28C" modified="2019-05-08" version="1" fragment="single">MTVSKYKCPRKEGSCDFELDDCGFTVDNKNGWTRRMKASTGNFLTPSQDHTTGDVYGYFMHVRAGPDLERQSVSMVSEEREQSLDQDACVYFWYHLRGPDVGRLAVKLRTSESVGDRSMWTMGKEQGDRWLQGRVQIPRGTGRYQLVFEAHLTDGVQGSIAVDDIQQEMGACPPEGTCDFDLDLCGYTSHTHNTNNDAETESRWLRLTSKYQISQHGPSAEHTQRHLNGGYAASDQFSFLAFEREPIARLLSPFLSATEKSCMSFWYYFDGFAEGTLRVLIGDVERFNTSSRFKDWRYSGVIEYENQSAHQIIFESERQGRGNALIAVDDILVGDCDDFQTPGTQSRDKTTEAPKPSIIPNLPVPDEGDTDHPLKINCYAYCMHFTSCYQQGKSHVYCVCQTGYSGSQCNIPDQQNEKPSGLDDNGNQDMNSKTSQTIKSKTDEGQGSNGGIIAVAVVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U1Y5</accession>
    <name>A0A433U1Y5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_004405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000100">
        <property type="protein sequence ID" value="RUS87806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U1Y5"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS87806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="265" mass="30363" checksum="BF9962ABC7E4F7A4" modified="2019-05-08" version="1">MYPSLAFSPCILTSQGEMRYVITDTTNINKHPLAIGVNRSISQDTDGVDADHDDICNRTVIVSCPDDDSPSLPPSPTASMGDADFSPVMWLSSNDDQNTSRDSGPYVELDLIRKCPQHDASMEGEYGWYMHRPSEPTKVYSPVERRKARERLSSSKSQPAREEDEAEYASFDEYTKFIKDTRIPSVYSDPQWVSLLQSIRSFDARSRPKTLHRQSSYMARRPTMDTLSRSRSRKIRNEFIFEGKEKSVDDLYSTLDDIEEQQEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U2R8</accession>
    <name>A0A433U2R8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">EGW08_004148</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">EC2010</strain>
            <tissue evidence="20">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="RQTK01000093">
        <property type="protein sequence ID" value="RUS88095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U2R8"/>
    <dbReference type="STRING" id="188477.A0A433U2R8"/>
    <dbReference type="OrthoDB" id="10057496at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16695">
        <property type="entry name" value="mRING-CH-C4HC2H_ZNRF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000363">
        <property type="entry name" value="E3 ubiquitin-protein ligase ZNRF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051878">
        <property type="entry name" value="ZNRF_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNRF1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661:SF4">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="15" id="KW-0458">Lysosome</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="19">
        <location>
            <begin position="153"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RUS88095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="196" mass="20965" checksum="458AA5728B658D22" modified="2019-05-08" version="1">MGLKLSTNNQQPRMRTYSASTPGGSNGGARPDVVTRNGQSARARARSLGNFQSPGNSGSLSIPGASGGTHRSSSPDSDSSSPGDDPAVLFGGRPFTHSLPVVPMHLFAVQGIKCPVCSKQIASDDIECHLVMCLTKPRISYNEDVLSEDKGECVICFEDLIQGDTIARLPCLCIYHKGCIDKWFEVNRSCPEHPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U2U7</accession>
    <name>A0A433U2U7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_004141</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000093">
        <property type="protein sequence ID" value="RUS88088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U2U7"/>
    <dbReference type="OrthoDB" id="39591at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057407">
        <property type="entry name" value="HEAT_TANGO6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039600">
        <property type="entry name" value="TANGO6/Rtp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057347">
        <property type="entry name" value="TANGO6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959:SF1">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23565">
        <property type="entry name" value="ARM_TANGO6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25267">
        <property type="entry name" value="TANGO6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TANGO6 N-terminal" evidence="2">
        <location>
            <begin position="14"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="TANGO6 HEAT repeat" evidence="1">
        <location>
            <begin position="373"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS88088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="644" mass="69721" checksum="424886E1D1704078" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U3A9</accession>
    <name>A0A433U3A9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Aquaporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_003888</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000086">
        <property type="protein sequence ID" value="RUS88317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U3A9"/>
    <dbReference type="STRING" id="188477.A0A433U3A9"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS88317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="30033" checksum="35B6DE01D3928992" modified="2019-05-08" version="1" fragment="single">AITLLGCGSHATYNDQNFLHVALTFGFIVATVVWVFNHVSGGHMNPAVTLAALFTRRVSIIRGVLYIVFQIIGGIIGAGILFGLTDSKKHFTDLGSNELSDSTTSAEGFGVEFMITLIYVLAYFACHDDKRSDLRGSAPLTLGVAVVACHIFAMPFTKAGMNPARSFGPALIADHWDDHWVFWVGPLVGGLVAGLLYEYIFASGATFAGVKKCLLRTKKPRKQAEPEKAPLEEIRTDAIEVDETKIDADAAPEVVVDKADTSAEDKTINGASADEIKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U4K5</accession>
    <name>A0A433U4K5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_003546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000075">
        <property type="protein sequence ID" value="RUS88731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U4K5"/>
    <dbReference type="OrthoDB" id="6093641at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019541769" evidence="1">
        <location>
            <begin position="21"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS88731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="255" mass="26990" checksum="681A8CC4E447522C" modified="2019-05-08" version="1">MGFLQVSLLPLLFLYMYTASIQISALGSSESTEKEAAVSETEADKRPYDSSYGAHGLSGFAKRPYDSAYGSHGLSGFAKRPYDSSYGAHGLSGFAKRPYDSSYGAHGLSGFAKRPYDSAYGAHGLSGFAKRPYDSSYGAHGLSGFAKRPYDSSYGAHGLSGFAKRPYDSAYGAHGLSGFAKRPYDSAYGAHGLSGFAKRPYDSAYGAHGLSGFAKRPYDSAYGAHGLSGFAKSLYDSIGEGKRSAEITDDEATSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U667</accession>
    <name>A0A433U667_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Core-binding factor subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_002929</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CBF-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000059">
        <property type="protein sequence ID" value="RUS89322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U667"/>
    <dbReference type="STRING" id="188477.A0A433U667"/>
    <dbReference type="OrthoDB" id="10026505at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016513">
        <property type="term" value="C:core-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.250.10:FF:000001">
        <property type="entry name" value="Core-binding factor subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.250.10">
        <property type="entry name" value="Core binding factor, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003417">
        <property type="entry name" value="CBF_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036552">
        <property type="entry name" value="CBF_bsu_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10276:SF3">
        <property type="entry name" value="CORE-BINDING FACTOR SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10276">
        <property type="entry name" value="CORE-BINDING FACTOR, BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02312">
        <property type="entry name" value="CBF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50723">
        <property type="entry name" value="Core binding factor beta, CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="198"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="223"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="262"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS89322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="34601" checksum="0E502FFFCC23410B" modified="2019-05-08" version="1">MPRVVPDQKTTFESDEFFRKLSRECEVRYTGFRDRPMDERQLRFQAECREGHADVAFVCTGTTLQLNFSANSWSERPEDRVLTSEYVDFDSEPGKVHLKSQFILNGVCVLWRGYIDLTRLDGVACLEFDRERAEVEARILRDQIEENSRRVQEFEDHRLQQIQLDQERQERQERLERREMQASSEAEVVEALLRFSEAPQGGNSSSCSSSSSSSVTPQPSHLQHQHLHPQHHQHQHHLQEQHHQHHQQQEQHQHQQEEQHQPYHHQHYHQHHHSHHHHLQTDHNHNHHLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UAJ2</accession>
    <name>A0A433UAJ2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prokineticin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_001347</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000023">
        <property type="protein sequence ID" value="RUS90840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UAJ2"/>
    <dbReference type="OrthoDB" id="6055622at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.80.10">
        <property type="entry name" value="Lipase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019575471" description="Prokineticin domain-containing protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS90840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="20696" checksum="FDBB41B92A200F0E" modified="2019-05-08" version="1">MGVVFTSRQLTTLAVAYLLLLGAVKTQDRIEMKCNPSFRHRYEICPAGYCCVRDEFLPTFVYCRKFGDQYDNCTTKETESECPCADGLKCLANIQGKFPSVYGRCVVNATTPATTVTTASPATTEPVSTNLTTVADETTAMVNISSTMVSPDGNTTLTQEQTTEVPLFNTTDSMFNSTDASDNSTLTQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UBD2</accession>
    <name>A0A433UBD2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_001121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000018">
        <property type="protein sequence ID" value="RUS91096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UBD2"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS91096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="745" mass="83863" checksum="047080757AEFDF1B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UBV6</accession>
    <name>A0A433UBV6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_000874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000013">
        <property type="protein sequence ID" value="RUS91357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UBV6"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS91357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="87" mass="9455" checksum="309758CA2BEE96E6" modified="2019-05-08" version="1" fragment="single">AVHEESVVEGHLAGLDRAAHRLACVVQLLRYGLVGGQKVALLGLSYMLQNTAFRFTWDDLHAGVFIIGVIHCHPDTDHISLKAPVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UC84</accession>
    <name>A0A433UC84_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_000838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000012">
        <property type="protein sequence ID" value="RUS91408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UC84"/>
    <dbReference type="OrthoDB" id="425681at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS91408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="199" mass="22900" checksum="4602B236BBAC5BCD" modified="2019-05-08" version="1">MRTNKSVLEEIGSPKLMLKTIDVRMLRYFGHACRHTDTGLMLNVLQGRTQSIRKKGRPPTSYIENIKKSLSLNFAKHHLRQSGQEQMASYCGQSIKTVTVGERAVRTSFYLLRLCNDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDAYKIFIDRLLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UDS1</accession>
    <name>A0A433UDS1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_000188</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000003">
        <property type="protein sequence ID" value="RUS91975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UDS1"/>
    <dbReference type="OrthoDB" id="6133051at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008467">
        <property type="term" value="F:[heparan sulfate]-glucosamine 3-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037359">
        <property type="entry name" value="NST/OST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605:SF65">
        <property type="entry name" value="GH20068P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605">
        <property type="entry name" value="HEPARAN SULFATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="8">
        <location>
            <begin position="100"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="49"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="active site" description="For sulfotransferase activity" evidence="3">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="108"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="313"/>
            <end position="317"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS91975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="355" mass="41550" checksum="32BED1E9D713F0A3" modified="2019-05-08" version="1">MISTVLTSRKSKAIAVWCGILLLVLCLHVYMSYQDVGVPGIGRRLYGDNSQFRDPPPYNQYGNAKTIKRPTEPKQPSTPAVPQKLYTPPDNEEKKQRFPRALIVGTGKCGTRALIDYLNMHPYVVTAKREMHFFDRDENWSRGVNWYKSQMPYSYSDQMTIEKSPSYVEHPRTPSAVKQMDKDMFILWVVKDPVVRLMSVMALQDENSNLRHAYLEYGRDGKLGIRKDYYPLWRGEYVIHLRRWLRYFPLSQIHVLDGTDLVKDPITQIQNVESFLQLQPLLGPRNFYYNASKGFYCMVPFSTTTPQCLGSSKGRKHPVINETVKTMLYDFFRPYNEQFFKLLGKRFNWEPKDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z7E1</accession>
    <name>A0A3S0Z7E1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_021176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001278">
        <property type="protein sequence ID" value="RUS71072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z7E1"/>
    <dbReference type="STRING" id="188477.A0A3S0Z7E1"/>
    <dbReference type="OrthoDB" id="445152at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039782">
        <property type="entry name" value="VPS13B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12517:SF0">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12517">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 13B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS71072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="262" mass="28019" checksum="17074C243F098CF7" modified="2019-04-10" version="1" fragment="single">MYEVPSVSINVSKASILMVSRVLSSWLSPSSPSSFYATRETRSAESYTTHRLVAGDSLLDDLFPVSGETTHQTFPMLELGLCGLEFKSCKSKLVDAFSGGLSSMHVLLYTPGIGGRMSAIPILYGPTDTSNICDTKFFTAASLEPSSVRSDCITATVQIPKHTSVSEAQALMLVDCQGLCVWLDPGLVAWFHYCPQPRPGHGSSADRPAVTLDLSLAQMTSPLNAVSQASVHSTSSPSHQGGHSRHQTSTSQPHVPPSPRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z8H6</accession>
    <name>A0A3S0Z8H6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_019090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000972">
        <property type="protein sequence ID" value="RUS73148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z8H6"/>
    <dbReference type="OrthoDB" id="6287208at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS73148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="349" mass="38917" checksum="16FCD1348B68FE52" modified="2019-04-10" version="1">MRLFHPQSLGAEDATTPPFLADKEMDSRLNLLRETTQVIKEGKHRLPTPEKAAIMRLSNSFEKRRLGKQQQILSEMTQRCREQEVTDLSSKISAKCDLKSHDKGAHANPFYSTTTRAGKGRLVSDLAMEGSPEIAFGNSKSPTGAQRHNSEKAYKFFPARHIIRQQTKIGPMSPTVTLPKMATKAYMGGSTANLDSFRSPRYFSHSFQNLDTIGVDSPRRVRNQVLNTTYPQTSRAESLAPLVLPRLSMVDMGYQDRIDSYFSTNPLAFAPRSKTILDAASISGRSYRSLINLSSRTNRQSLVHGRSGLKSERSEQGGLMNIPFQHDDDRHSLESVGRGFGQSIDNLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZCM2</accession>
    <name>A0A3S0ZCM2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_020348</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001144">
        <property type="protein sequence ID" value="RUS71895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZCM2"/>
    <dbReference type="OrthoDB" id="6126859at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="55"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS71895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="365" mass="41044" checksum="E642A75ACD17F792" modified="2019-04-10" version="1">MDNDHQNDTGFDANNTVKALIAMETTPSYMEDTYNTISSIVSWIIVVNGTLGLIGNILTVVVYTKLGFSETIHMSYVALAISDFFCLLTLLYVRFCFTAEIKSIFLRYRMLLDETLFANFTGAWPNHGFTRTTALLTAWISLERCLCVLFPTRVKLMITPRVTKIVLTVIFTIGCCPVALAFIGIKTEMDFDPETNYTTLILRYSHGNQDLNPANRIAFVLYGALYPIASWLIVVVCAFFLITALKRSARWRSINTRSHIGKSTGSCAEKESRKIPSREARVTRTVVVIACAFIFFSLPISATVVIAFVYRDFSVKGYLHYPLLISVTFSFLFGGLNSSINIVVYTLTGSKFRSTLIELFKRNHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZDS7</accession>
    <name>A0A3S0ZDS7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_019550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001031">
        <property type="protein sequence ID" value="RUS72694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZDS7"/>
    <dbReference type="OrthoDB" id="6092848at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018769248" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS72694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="27785" checksum="DC445D0E8C9CD16F" modified="2019-04-10" version="1" fragment="single">MESVALPVLCTCLFLVLAVQGEDERQVHCLGPNKPVQLENPFSDEQMKNVVAYYWFFKPKESLKEELLLSYTFTTVTVDNPRWKQYKEYGAQLDNPNLNDTGTYRASLTTLSTRTDINSEVILIIVDPPTLAEDMLVLFRKVSSETGETSLRCGALQNRGEPAVDLVLMGTDGSLMQSVYDNGYQIAILKEDVAEGTYKCKVADESPGRECISSQEEFWEAEYLLKKPKGGSSGNNVNKQCHSEVLYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZE27</accession>
    <name>A0A3S0ZE27_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Anti-silencing function protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_019350</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ASF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001004">
        <property type="protein sequence ID" value="RUS72890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZE27"/>
    <dbReference type="STRING" id="188477.A0A3S0ZE27"/>
    <dbReference type="OrthoDB" id="29755at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1490:FF:000001">
        <property type="entry name" value="Histone chaperone ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1490">
        <property type="entry name" value="Histone chaperone ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006818">
        <property type="entry name" value="ASF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036747">
        <property type="entry name" value="ASF1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040">
        <property type="entry name" value="ANTI-SILENCING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040:SF0">
        <property type="entry name" value="HISTONE CHAPERONE ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04729">
        <property type="entry name" value="ASF1_hist_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101546">
        <property type="entry name" value="ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="202"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS72890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="27009" checksum="470DCF31CCD4262B" modified="2019-04-10" version="1">MALVNICDVTVLNNPTSFLKPFQFEITFECLEDLPEDLEWRIIYVGSAESMDHDQVLDTILVGPVPGGKHMFVFEADPPDVRKIPVDDIMGVTVVLLTCSYRSKEFIRVGYYVNNEYDDPELKENPPAEIQFQKLTRNILSSEVRVTRFTIPWHDTKGGEEDGEEKMEEDVAGTSETGIMPAPKISDEIQARITADLAYERAERERMTSKGPLTDPGNIYPDEMRHYHSEDSSSLCMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZE56</accession>
    <name>A0A3S0ZE56_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 3 subunit D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_015380</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000629">
        <property type="protein sequence ID" value="RUS76847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZE56"/>
    <dbReference type="STRING" id="188477.A0A3S0ZE56"/>
    <dbReference type="OrthoDB" id="16538at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007783">
        <property type="entry name" value="eIF3d"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05091">
        <property type="entry name" value="eIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="98"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS76847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="48066" checksum="F73AE85BE9F6FABD" modified="2019-04-10" version="1" fragment="single">MVKMTTAHFIPPQIQDNPTGWGPNEIPDQFKDMPYQPFSKDVRLGKVSDWTGSTYQDKRYLGKYNSAFGGGSQYAYYHEEDESTFQLVDTSRVQKPVYQRRGRLFQQNRQRRDRERRQQQTQASMQVLTKTQKNRERDRQRILKKWQKQFGKQMQENRSKMPIRNRDASVQIKDDWVVVEEMDFPRLTKLNLPDIKDGEDMVTCGAMEFYDKSYDRVTTKNPKRLRRINRIFHKVTTTDDPIIRRLAKDQGNVFATDAILATMMCCPRSSYSWDVVVQRVGNKLFFDKRDDSDFDLLTVSETATEPPQEDGSNHINSPRSLALEATFINHNFSQQVLRMKEEKHDFEENNPFAQSGEESEVASVGYRYRKWDLGNDVVLIARTEHDAVTSGPNNETHFMNIKALNEWDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZFU8</accession>
    <name>A0A3S0ZFU8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">galactosylceramidase</fullName>
            <ecNumber evidence="2">3.2.1.46</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Galactosylceramidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EGW08_018334</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">EC2010</strain>
            <tissue evidence="16">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 59 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.46" evidence="2"/>
    <dbReference type="EMBL" id="RQTK01000888">
        <property type="protein sequence ID" value="RUS73898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZFU8"/>
    <dbReference type="STRING" id="188477.A0A3S0ZFU8"/>
    <dbReference type="OrthoDB" id="6116466at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004336">
        <property type="term" value="F:galactosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006683">
        <property type="term" value="P:galactosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049162">
        <property type="entry name" value="GH59_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049161">
        <property type="entry name" value="GH59_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001286">
        <property type="entry name" value="Glyco_hydro_59"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035394">
        <property type="entry name" value="Glyco_hydro_59_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15172">
        <property type="entry name" value="GALACTOCEREBROSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15172:SF1">
        <property type="entry name" value="GALACTOCEREBROSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02057">
        <property type="entry name" value="Glyco_hydro_59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21708">
        <property type="entry name" value="Glyco_hydro_59_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17387">
        <property type="entry name" value="Glyco_hydro_59M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00850">
        <property type="entry name" value="GLHYDRLASE59"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0746">Sphingolipid metabolism</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 59 catalytic" evidence="13">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 59 central" evidence="14">
        <location>
            <begin position="241"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 59 C-terminal lectin" evidence="15">
        <location>
            <begin position="394"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="12">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601286-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RUS73898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="567" mass="63597" checksum="5B88F048CC529B7A" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZIF6</accession>
    <name>A0A3S0ZIF6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_013701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000504">
        <property type="protein sequence ID" value="RUS78523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZIF6"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS78523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="122" mass="13123" checksum="3766D5F789AC8AA1" modified="2019-04-10" version="1" fragment="single">CEENIVDVHGCFRRSLHEEKAVLLCVGLGLVVLHHALAGKISLVACQGYHNVGAGLSLELLHPGLGAAKCSTHRICDVVDDYCCLGPPVVHRCETVVPLLAGCVPNLKLYCRVVKTHCLCEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZJ18</accession>
    <name>A0A3S0ZJ18_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_016354</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000703">
        <property type="protein sequence ID" value="RUS75895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZJ18"/>
    <dbReference type="STRING" id="188477.A0A3S0ZJ18"/>
    <dbReference type="OrthoDB" id="3196451at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20806">
        <property type="entry name" value="C1_CHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000019">
        <property type="entry name" value="Chimaerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000025">
        <property type="entry name" value="Chimaerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051854">
        <property type="entry name" value="Rho-type_GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46075">
        <property type="entry name" value="CHIMERIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46075:SF2">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 5A, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SH2" evidence="5">
        <location>
            <begin position="45"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="6">
        <location>
            <begin position="214"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="7">
        <location>
            <begin position="279"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS75895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="41107" checksum="7955524F45A05B57" modified="2019-04-10" version="1">MYMIFLKLKKLENLIYQLQLQAPQPICIPPKHEIPNRPPQYDPKEFHGTLSRQEADILLQGGDGYYLVRKSERAPDSFTLAIRFDNETKNYKLYYDGQHFVGEKRFDSVYDLVADGLIHFFIELRAADYIKTLSQESNYEESPYMAFKGRYMTGNSSRTEGANGVASEVRIVQFPFSYQILSFQLEQCCASDTTEQANINDDEIKLYNCKKLCECFFVCSQVQNFVGHWCDFCANFMWGLIAQGVKCQDCGFQAHKRCSEKVPNDCMPDMKYVKRIFGGDLTTVVKAQKSLIPIVVEKCVKEIELRGMDQEGLYRLAGFHDDVEALRMAFDKEMNGLNARFMRLFKCLQTDFVRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZJB6</accession>
    <name>A0A3S0ZJB6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-asparaginase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_016143</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000687">
        <property type="protein sequence ID" value="RUS76112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZJB6"/>
    <dbReference type="STRING" id="188477.A0A3S0ZJB6"/>
    <dbReference type="OrthoDB" id="542841at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="entry name" value="L-asparaginase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500176">
        <property type="entry name" value="L_ASNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="L-asparaginase N-terminal" evidence="3">
        <location>
            <begin position="16"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="active site" description="O-isoaspartyl threonine intermediate" evidence="1">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="97"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS76112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="194" mass="20831" checksum="45CDB26C2641F0A9" modified="2019-04-10" version="1">MLNMTAAPNFSSCRDVLILQTGGTIDKNYPQRPGAYGFEIGKPAVENILERTRPAFSVRVDVVCAKDSQEITDADREDILRCVVEADEELVLVTHGTDTMCQTAQYLARAGVGQGRDFGPGVGEKKVVITGSFQPECVKDTDADFNVGFALGALQTVSGPGVWVAMRGALLPGAFVVRTDAGDFVDKRSFLPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZQY4</accession>
    <name>A0A3S0ZQY4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_008478</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000231">
        <property type="protein sequence ID" value="RUS83772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZQY4"/>
    <dbReference type="STRING" id="188477.A0A3S0ZQY4"/>
    <dbReference type="OrthoDB" id="10072198at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS83772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="326" mass="37287" checksum="6DD46E75D4A2F7D1" modified="2019-04-10" version="1">MNSTKHMAHCISNFHSLIGEYGFTQHVEQPTPNNPRTVEEFNIFLRDVLDQFAPLCERRISARPFAPWFTPRVQTAKQLSISLNSTLFVLILLHVLLLYTSISTYSLNHHDGDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDNDDDDDDDVFQTSFQYEKGVVVDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDNDHDRCNNDDFKPFVHNEKEGAGLAQVVERWSRDQHARGSNSTSGQKLFVRFRPLLFVSVSVSCGRLRHMSKSHSSVYCVAVRQTSFLGSVHNVAYLLLMSDVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZT42</accession>
    <name>A0A3S0ZT42_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_017602</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000813">
        <property type="protein sequence ID" value="RUS74622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZT42"/>
    <dbReference type="STRING" id="188477.A0A3S0ZT42"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16515">
        <property type="entry name" value="RING-HC_LRSAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051652">
        <property type="entry name" value="MDM2_MDM4_MUL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12183:SF32">
        <property type="entry name" value="MITOCHONDRIAL E3 UBIQUITIN PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12183">
        <property type="entry name" value="MITOCHONDRIAL UBIQUITIN LIGASE ACTIVATOR OF NFKB 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SAM" evidence="8">
        <location>
            <begin position="98"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="238"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS74622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="33450" checksum="B35FA03C69C810D1" modified="2019-04-10" version="1" fragment="single">LISQDAVNQRIQQQISLIETELAQITAAEILQREQRTEHEFTIVADQRIALSALLAQLLEERDKRRTELKKRLVEMELERENGQRDYWLVQYQRLLDWKPQSLIDKESQLEIAVKEILISAGAEEYIPKFARHRITIETMLTLTEDDLRQMGVYQVGLRKAILKNADLHRSEVDEQTKARAKEKSLDLEVDVRSKVPEPRVPVHEAPPTAPPPDSSSGASGLLPTQVSVTARGLNSECAICLDKESTIIFLPCGHVCCCAECSRSIGECPLCRAVISAQVKLTLTPAQPQAPQASAQGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZU69</accession>
    <name>A0A3S0ZU69_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cystinosin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_016845</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cystine(out) + H(+)(out) = L-cystine(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:66172"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:35491"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:66173"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cystinosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000746">
        <property type="protein sequence ID" value="RUS75383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZU69"/>
    <dbReference type="STRING" id="188477.A0A3S0ZU69"/>
    <dbReference type="OrthoDB" id="75720at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015184">
        <property type="term" value="F:L-cystine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000016">
        <property type="entry name" value="Cystinosin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005282">
        <property type="entry name" value="LC_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00951">
        <property type="entry name" value="2A43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131:SF5">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0769">Symport</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="56"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="285"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS75383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="38986" checksum="F8D2B6BEA17EF5A3" modified="2019-04-10" version="1">MESFDITNSTHESFVDPVVHSQALVYISSVLGWMYFTAWTMSFYPQVIINWRRKSVIGYSFDFVAFNFTGFVAYACFNTGLYWIPEIKAEYYKKHPEGVAPVELNDVFFSLHAFAITSVTVIQCIIYEKGSQKINTWARVLLVFVWTYVLITVILAAVGSMEWLDFLYSFSYIKVGVTVLKYMPQAYLNFARKSTVGWSIGNVLLDFSGGWLSILQMILNAYNGNDWASLEGNLTKLGLGVVTIIFDSIFIIQHYCLYWKANPYKPMDDDVEICVDVEKTKEKEKEKAAILRHHRRSEGGTGKVRRRSQSPAPRSYKSALTTPKASPNNNTSSALSRDAQDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZV91</accession>
    <name>A0A3S0ZV91_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_005567</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000131">
        <property type="protein sequence ID" value="RUS86693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZV91"/>
    <dbReference type="OrthoDB" id="6162548at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043:SF8">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="302"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="14"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="331"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS86693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="368" mass="40100" checksum="4E2387ACE2D1BF88" modified="2019-04-10" version="1" fragment="single">DPENGSCLVCTPGKSCDTDCYQGTEKTHKNDSESQGTTQKPEECPSEFWGPNCTQPCCSLCVDEICDPENGSCLVCTPGKSCDTDCYKVTHRIHGNDSESQGTTRVCPSEFWGPNCTQPCCSLCVDEICDPENGSCLVCTPGESCAIDCYQGTNKTHKNDSESQDTTQKPEECQSKFWGPNCTQPCCSLCVDEICDPENGSCLVCTPGMSCDTECYKPPETSTEGEAVYECPKTFWGFKCTNACCSLCSDYLCHPFTGTCFACLPGKDCKKDCYKVLTNSSLKNDVSKLAVSRDTSKKGNSALAGLIVFVSVAVGIQALVIVCSTLFQVPPPETGYKEDADVEGYEMKKKRQRKKQNKKERAKERGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZW59</accession>
    <name>A0A3S0ZW59_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Globin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Myoglobin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_007784</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="9">Belongs to the globin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000205">
        <property type="protein sequence ID" value="RUS84455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZW59"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050532">
        <property type="entry name" value="Globin-like_OT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458">
        <property type="entry name" value="BLR2807 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458:SF1">
        <property type="entry name" value="GEO09476P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00188">
        <property type="entry name" value="PLANTGLOBIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="4 9" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="10">
        <location>
            <begin position="22"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS84455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="187" mass="21276" checksum="AE95ED5768D73F2E" modified="2019-04-10" version="1">MGNTSAVSCLNDGAEGVHLNKYLTARQLELVQDTWDIMKTDLPTLGLTVFLKLFQTEPDLKRLFPKIVQMNDKNELEWEVDRDMLQRHAVTVMEGLGAAVESLDDSDFLNSVLVSIGQTHVKRHVKPAMLKRLWPSLNHGFQTMLGEVYTKETMEAWRRLYTYISSQMKRGMNDPDAKLSCDDVGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZYF1</accession>
    <name>A0A3S0ZYF1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_014009</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000524">
        <property type="protein sequence ID" value="RUS78240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S0ZYF1"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF36">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="782"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="811"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="835"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="889"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="928"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="971"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="1052"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="560"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="593"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS78240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1293" mass="145334" checksum="ED9A7806DE98E196" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZZD7</accession>
    <name>A0A3S0ZZD7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Threonyl/alanyl tRNA synthetase SAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_013302</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions in trans to edit the amino acid moiety from incorrectly charged tRNA(Ala).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000481">
        <property type="protein sequence ID" value="RUS78924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZZD7"/>
    <dbReference type="STRING" id="188477.A0A3S0ZZD7"/>
    <dbReference type="OrthoDB" id="288942at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002196">
        <property type="term" value="F:Ser-tRNA(Ala) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043039">
        <property type="term" value="P:tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.130:FF:000003">
        <property type="entry name" value="alanyl-tRNA editing protein Aarsd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000007">
        <property type="entry name" value="alanyl-tRNA editing protein Aarsd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051335">
        <property type="entry name" value="Alanyl-tRNA_Editing_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462">
        <property type="entry name" value="ALANYL-TRNA EDITING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462:SF1">
        <property type="entry name" value="ALANYL-TRNA EDITING PROTEIN AARSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Threonyl/alanyl tRNA synthetase SAD" evidence="9">
        <location>
            <begin position="196"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS78924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="423" mass="46360" checksum="35B87BE1ED3E78EE" modified="2019-04-10" version="1">MSFMCQKDSYLKEYRTKVKSCKPASTTILENGKKTKVKGYEVILEDTILFPEGGGQPDDRGTINDIPVLKITRSWEDAVHFLPSEIPEGTDVSLKVDWQRRFDHMQQHTAQHLITAIVDHKFGYETTSWNLGSDIVTIELGTPTFSTNQLAEVEEEVNECIRRQISVTPTLYPDKDDPELLKFRGLGLPADHVGSVRVVTIEGVDSALCCGTHISNLSHIQAIKLLGTEKGKKDKTNLLVLAGNRLRRYAGNSFDREKQLAGILKGPAEKQSELAEKAVKGMKNYQKICNAQLKELAALEVSLFKKTEPNDTVFVKHRKDGDSDYISVLMSELGDENLPKLITVGDEKEGGMFVVGGPAQLVSDLGPRICALFGGKGAPNKGSVFRGKANELSLSSRAAAEKLMRDFVAGRGDGASVAVGDEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A2A8</accession>
    <name>A0A3S1A2A8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Delta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_000252</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Putative Notch ligand involved in the mediation of Notch signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000003">
        <property type="protein sequence ID" value="RUS92039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A2A8"/>
    <dbReference type="STRING" id="188477.A0A3S1A2A8"/>
    <dbReference type="OrthoDB" id="6126020at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000125">
        <property type="entry name" value="Neurogenic locus notch protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001774">
        <property type="entry name" value="DSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01414">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 9" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6 7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 7 9" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="DSL" evidence="13">
        <location>
            <begin position="299"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="347"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="387"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="432"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="630"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="669"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="709"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="864"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="954"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1124"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="434"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="636"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="680"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="711"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="757"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="804"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="821"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="954"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="967"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="990"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1028"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1124"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1180"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU280815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS92039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1193" mass="131608" checksum="2254F35DCE512C5C" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A6S6</accession>
    <name>A0A3S1A6S6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16 17">Diphosphomevalonate decarboxylase</fullName>
            <ecNumber evidence="4 16 17">4.1.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">EGW08_000208</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">EC2010</strain>
            <tissue evidence="20">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 17">Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16 17">
            <text>(R)-5-diphosphomevalonate + ATP = isopentenyl diphosphate + ADP + phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:23732"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 17">Steroid biosynthesis; cholesterol biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 16 17">Belongs to the diphosphomevalonate decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.33" evidence="4 16 17"/>
    <dbReference type="EMBL" id="RQTK01000003">
        <property type="protein sequence ID" value="RUS91995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A6S6"/>
    <dbReference type="STRING" id="188477.A0A3S1A6S6"/>
    <dbReference type="OrthoDB" id="10253702at2759"/>
    <dbReference type="UniPathway" id="UPA00063"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004163">
        <property type="term" value="F:diphosphomevalonate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000018">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000005">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005935">
        <property type="entry name" value="Mev_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029765">
        <property type="entry name" value="Mev_diP_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053859">
        <property type="entry name" value="MVD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041431">
        <property type="entry name" value="Mvd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01240">
        <property type="entry name" value="mevDPdecarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977:SF3">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18376">
        <property type="entry name" value="MDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22700">
        <property type="entry name" value="MVD-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015950">
        <property type="entry name" value="Mev_P_decrbx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0152">Cholesterol biosynthesis</keyword>
    <keyword evidence="17" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="6 17" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 16 17" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14 16 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 16 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="13 17" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10 17" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="12 17" id="KW-1207">Sterol metabolism</keyword>
    <feature type="domain" description="Diphosphomevalonate decarboxylase-like N-terminal" evidence="19">
        <location>
            <begin position="16"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Mvd1 C-terminal" evidence="18">
        <location>
            <begin position="198"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR015950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU363086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF18376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF22700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RUS91995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="401" mass="44064" checksum="C4E2F8EC613698DB" modified="2019-04-10" version="1">MSGKSNPNVRCVTCTAPVNIAVIKYWGKTDETRILPTNPSLSVTLGQDELRAKTSVAASSSFTEDRLWLNGIEQSISSPRIQNVLKEIRRRAHKRKSGDSKNDVVLTQHVHIVSENNFPTAAGLASSAAGYACLVFALGKLFGVHGEISDIARQGSGSACRSLYGGYVLWKMGSKEDGSDSHAVQVQPETHWPQMRSLILVVSDQKKHVGSTEGMQTTVQTSDLMEKRIKLVDKRTAEITKAINERDFPTFAKITMQESNQLHAVCLDTYPPIFYMTDTSRLIVRLVHAINDISGKVKVAYTFDAGPNACLYLLEEDVPRVLSLVRHFFPPSKDMKDSSFVTGLKLDEIKPLSGDISQINIPISEGAVKYVIHTNVGPGPQVLTDPKESLFTSEGKPRLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AQJ1</accession>
    <name>A0A3S1AQJ1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_023040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001784">
        <property type="protein sequence ID" value="RUS69195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AQJ1"/>
    <dbReference type="STRING" id="188477.A0A3S1AQJ1"/>
    <dbReference type="OrthoDB" id="27298at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009022">
        <property type="term" value="F:tRNA nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11362">
        <property type="entry name" value="RNase_PH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000003">
        <property type="entry name" value="Ribonuclease PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00564">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002381">
        <property type="entry name" value="RNase_PH_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018336">
        <property type="entry name" value="RNase_PH_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01966">
        <property type="entry name" value="RNasePH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF0">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01277">
        <property type="entry name" value="RIBONUCLEASE_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="6">
        <location>
            <begin position="10"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="7">
        <location>
            <begin position="159"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS69195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="235" mass="25733" checksum="AD22C6991878E274" modified="2019-04-10" version="1">MRPSGRSNDQLREMKVTHNFTKHAEGSVLVEFGDTKVLCTASVTEGVPRFKKDSGEGWLTAEYGMLPRSTHTRMDREAARGKQSGRTQEIQRLIGRALRASVDLSKLDNFTIRVDCDVIQADGGTRTASITGASLAIKDAIKYMHDNEMLDKELNPLLNPVAAISVGIYKDAPVLDLDYDEDSNAETDMNVVLNSAGGMIEVQGTAEGKDFSEEEFGKMLGLAKKGIKEIFAKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AUQ3</accession>
    <name>A0A3S1AUQ3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_023441</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01002009">
        <property type="protein sequence ID" value="RUS68795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AUQ3"/>
    <dbReference type="STRING" id="188477.A0A3S1AUQ3"/>
    <dbReference type="OrthoDB" id="6132286at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="267"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS68795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="473" mass="51856" checksum="86CEC27980C5B17E" modified="2019-04-10" version="1">MPGARSAAMPAPEGTQPVTASTLVVYAPRDAVIDRFYGDGGVSETERFLTRIQRAWESPQFASDRAKVNFLFDNVGESVEKEILCTLSGAEPSPNQLVKIIQSCYGEKRSMPALIRELYNIKQRRGEGIRQFSLRLQDAYNSVRRREETEAAASPIGADTLRDIFIENLADKSIRRELRQCLKRGALSTFKDARIQALELEDDPSDSESDRRDYVGVRHITSAPLPSECTHTQSIKALTDQVARLTGLVERLLMQGAQNANLPRPQSQHKKNTRAPPSRRRGQNQTGAVCFNCGRHGHFARVCPVVAGNQRVSPAPRESQDRWGRARERPVQPHLDTRGTHVGLRGADYGAEAVGLHNTIGQCHVADAGETAATSSATLRRNTAVGSLSNSKEEPGLTLAATSCGIDVSIAGTVGVDNRSTPPPQVVEAMIADYVTDSQRAELRGLVAESTDLCNVRNLELRPFVSHRSEARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AZ61</accession>
    <name>A0A3S1AZ61_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BLOC-1-related complex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_020214</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BORCS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001126">
        <property type="protein sequence ID" value="RUS72030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AZ61"/>
    <dbReference type="STRING" id="188477.A0A3S1AZ61"/>
    <dbReference type="OrthoDB" id="5567844at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099078">
        <property type="term" value="C:BORC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032143">
        <property type="entry name" value="BORCS7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31397:SF1">
        <property type="entry name" value="BLOC-1-RELATED COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31397">
        <property type="entry name" value="BLOC-1-RELATED COMPLEX SUBUNIT 7 BORSC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16088">
        <property type="entry name" value="BORCS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0458">Lysosome</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS72030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="104" mass="11633" checksum="903BB70A23EFE9D6" modified="2019-04-10" version="1">MASNKAAAASWNQETKARLNDKVSSNINDIGSILRQAIRGSKSPDFLAQAAKNFASQESYIHNSHETMRKMDLLRSQLEFQHSSINRSLSCLDEVQDQLSSINH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AZS1</accession>
    <name>A0A3S1AZS1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Guanine nucleotide-binding protein subunit alpha-12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_015903</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000670">
        <property type="protein sequence ID" value="RUS76341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AZS1"/>
    <dbReference type="STRING" id="188477.A0A3S1AZS1"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031526">
        <property type="term" value="C:brush border membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031752">
        <property type="term" value="F:D5 dopamine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000754">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000469">
        <property type="entry name" value="Gprotein_alpha_12/13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF360">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00440">
        <property type="entry name" value="GPROTEINA12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="43"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="177"/>
            <end position="183"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="202"/>
            <end position="206"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="271"/>
            <end position="274"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS76341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="41609" checksum="AED09D25FF10E9F9" modified="2019-04-10" version="1">MFCCISEHEKSQKTRSREIDKKLNKDRLTFRRTVRVLLLGAGESGKSTFLKQMRIIHGQEFDDDQVREYRTVIYNNILKGMRVLIDARQKLSIPWEDESCVKDAATVFDFSGSTKLDQSMFCDYVDSLKKLWKDSGIRTAFDRRREFQLVRKFNTAFHIHSQVSGPINYIPSKQDILLARKATKGVIEHQIMIKGVPFMFIDVGGQRSQRQKWFQCFEGITSILFLASASEFDQVLMEDRKTNRLVESCNIFETIINNRSFASVSIILFLNKMDLLQEKVAAVDLSQYFPEFKGDPRSLEDVKNFLCDLFDSRRRERAKPLFHHFTTAIDTENIKHVFQDVKDTILHDNLRTLMFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B0Y2</accession>
    <name>A0A3S1B0Y2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_023004</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001767">
        <property type="protein sequence ID" value="RUS69233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B0Y2"/>
    <dbReference type="STRING" id="188477.A0A3S1B0Y2"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18024">
        <property type="entry name" value="DEXHc_Mtr4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13154">
        <property type="entry name" value="KOW_Mtr4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000083">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000141">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.300:FF:000001">
        <property type="entry name" value="Mtr4 exosome RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000002">
        <property type="entry name" value="superkiller viralicidic activity 2-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="120"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="378"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS69233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1015" mass="115287" checksum="BE0714893C9CF6FD" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B2Y8</accession>
    <name>A0A3S1B2Y8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Insulin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_017384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000793">
        <property type="protein sequence ID" value="RUS74860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B2Y8"/>
    <dbReference type="OrthoDB" id="6139049at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS74860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="25031" checksum="B2F92003F79C0E90" modified="2019-04-10" version="1" fragment="single">PDYIKHLHFLQQLTHDLTSSSAVGVSRDQRQKDTSSLLVLRRLVRLHLREKTVWVNYPAEKMHRPALLDVCVLAVLVLVLVLAPRTEAQQSEAPDRVCYGTRNRPARGGICGSAIPNAVASVCGRAGKRSGGATDTIDFSQFKKVERTRSFDLEKRDAFEFLQKRSSFTGIVCECCYNTWRKEMPSSFYRSGQALRALCVSVATTRVVSVSCASTANEGAIPDTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B7Q8</accession>
    <name>A0A3S1B7Q8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_018147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000867">
        <property type="protein sequence ID" value="RUS74084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B7Q8"/>
    <dbReference type="OrthoDB" id="418245at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS74084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="199" mass="21407" checksum="22D5978A51CB63DF" modified="2019-04-10" version="1" fragment="single">WLWYDHPCGGLRFHYNYICEFPLSRPSDTEGQVAPSAASQEEDNGNGSALIIILGMGMAIIVLMMVIAALLHFHHRRSKRRHAETELPIRYANNHHSHTSHSSLASAANQRNHCNHSQQHSSSNTCSSGGSNSCSGQSSGSIPQTTVVPPGRPPAPPAAIRAQQEEARAPFLYSEVNRPRGQSNSIHVGTTASAGIGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B824</accession>
    <name>A0A3S1B824_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerases I, II, and III subunit RPABC3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_017941</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB8 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000846">
        <property type="protein sequence ID" value="RUS74290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B824"/>
    <dbReference type="STRING" id="188477.A0A3S1B824"/>
    <dbReference type="OrthoDB" id="10249565at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005570">
        <property type="entry name" value="RPABC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03870">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000779">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00658">
        <property type="entry name" value="RPOL8c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS74290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="12581" checksum="210A880219F3F166" modified="2019-04-10" version="1">MDLILDVNTQIYPVALGDKFRLVIATTLREDGCPDDGEFQPTSSGPSRADQFEYVMYGKVYRIESDGNQDSGRLAAYVSFGGLLMRLMGDPNNLHGFEDDSRIYLMMKKLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B9Q7</accession>
    <name>A0A3S1B9Q7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">T-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_016787</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000741">
        <property type="protein sequence ID" value="RUS75464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B9Q7"/>
    <dbReference type="STRING" id="188477.A0A3S1B9Q7"/>
    <dbReference type="OrthoDB" id="7442607at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.820">
        <property type="entry name" value="Transcription factor, T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046360">
        <property type="entry name" value="T-box_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036960">
        <property type="entry name" value="T-box_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00907">
        <property type="entry name" value="T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50252">
        <property type="entry name" value="TBOX_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="T-box" evidence="7">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="99"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="177"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS75464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="352" mass="38403" checksum="8F66E210D0A94B00" modified="2019-04-10" version="1">MPSPSSCPPSSDTVKTVCSVSPETSPGTVRSPSPTNQNRQPYLGQQSQVQHVHQPFNTLHGQSYPYPHHFLGQVYSSHKMYSQQYANSQPQILPQLTHQQHQDFLTKGRRAASTSSSSPSSSSLPPSPDFPHHHIQHPQAHFDPHLPPVATPVRPQQLSPKASNFSIAAILGGSFTRNTQSSSSSNSVITTHHSPNSSSDKSRFTGNGESCATTRKIRDSHILARGVRRPAAYNFELDSAESRPNSPTPPLTPTTPSVTSPTRDCDVDVEIDVDGNDSAAIATLPQRKCPDASCNDDISSTCKPSISKAKDEVLKAREEGETTKVKCRLETKDLWDKFHELGTEMIITKTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BAA7</accession>
    <name>A0A3S1BAA7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_012787</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000450">
        <property type="protein sequence ID" value="RUS79446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BAA7"/>
    <dbReference type="STRING" id="188477.A0A3S1BAA7"/>
    <dbReference type="OrthoDB" id="276276at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004081">
        <property type="term" value="F:bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006167">
        <property type="term" value="P:AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006754">
        <property type="term" value="P:ATP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03428">
        <property type="entry name" value="NUDIX_Ap4A_Nudt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051325">
        <property type="entry name" value="Nudix_hydrolase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003565">
        <property type="entry name" value="Tetra_PHTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21340:SF0">
        <property type="entry name" value="BIS(5'-NUCLEOSYL)-TETRAPHOSPHATASE [ASYMMETRICAL]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21340">
        <property type="entry name" value="DIADENOSINE 5,5-P1,P4-TETRAPHOSPHATE PYROPHOSPHOHYDROLASE MUTT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01405">
        <property type="entry name" value="TETRPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="6">
        <location>
            <begin position="37"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS79446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="175" mass="20405" checksum="56A6891441CB7229" modified="2019-04-10" version="1">MNWNQFRAVILTCFNANSYFKTSYLCRHIVKMASTSEPLVAAGFIIFRKLQNETEYLLLQTSYGQNHWTPPKGHVDPGESEFETALRETEEEAGIRKNQMKIVEDFQRTLNYSVNGKSKRVVYWLSELCNPEDPIKLSHEHIDFKWQKLDNACQLAQFSDMVELLKEVDSHLQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BAH2</accession>
    <name>A0A3S1BAH2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">IRS-type PTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_012679</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000444">
        <property type="protein sequence ID" value="RUS79549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BAH2"/>
    <dbReference type="STRING" id="188477.A0A3S1BAH2"/>
    <dbReference type="OrthoDB" id="6243387at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050996">
        <property type="entry name" value="Docking_Protein_DOK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21258">
        <property type="entry name" value="DOCKING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21258:SF62">
        <property type="entry name" value="INSULIN RECEPTOR SUBSTRATE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02174">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01244">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00310">
        <property type="entry name" value="PTBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51064">
        <property type="entry name" value="IRS_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IRS-type PTB" evidence="2">
        <location>
            <begin position="132"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS79549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="570" mass="63447" checksum="AFF4DC5754483AAC" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BB32</accession>
    <name>A0A3S1BB32_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_015807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000662">
        <property type="protein sequence ID" value="RUS76438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BB32"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS76438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="245" mass="26508" checksum="AE5AA69BB915BC96" modified="2019-04-10" version="1">MGASINTELDATATAGDHFPVWRPPLRPGGTTPADDGRIKGDNVAPQEHVWPTLRLDQGRGVFKHAYPSDGQHRTFRTTLILLVTRQAHVHLGSTVDTDGVVTCATGLAGTRVGGQEESGQAPRQEDQDSLLSWRASLMSHIVPESGGHPDGEMVTIKTLLTALLKANSWSRRLPSGSAHRLLRVRNKLRRPELPDLTRGLGDVCGKESVGWSAHTVDASVRHRVNQHQLKKEAIIAASCPSGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BEF2</accession>
    <name>A0A3S1BEF2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_010486</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000322">
        <property type="protein sequence ID" value="RUS81732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BEF2"/>
    <dbReference type="STRING" id="188477.A0A3S1BEF2"/>
    <dbReference type="OrthoDB" id="6100089at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS81732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="211" mass="23831" checksum="F5F8312D81A080A5" modified="2019-04-10" version="1">MQILLEGYGLDLDLNISRIGQVQGKIKKKIYFAKMNDLHVCRESSVSKFVLVKESRAVHIDLQPFLTQSHLGNGFQSSWFQSCHLHEVLSLIKSPLETALDEAGSLNVDNKKKTPSREFVLTGETVRIACTFKPQPEEDIFLASQKRSRINDGTKSPMRHCFCQLDMHPEKLLCYVCPRSNSSTLQLSQIVNAMPSSQQEDISKYFQPAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BEZ7</accession>
    <name>A0A3S1BEZ7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_012993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000462">
        <property type="protein sequence ID" value="RUS79263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BEZ7"/>
    <dbReference type="STRING" id="188477.A0A3S1BEZ7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS79263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="176" mass="19627" checksum="424B8C9EF503C322" modified="2019-04-10" version="1" fragment="single">QGEVTHNLRDGIFHMIHTGITSQGEVTHNLRDGIFHMIHTGITSQGEVTHNLRDGIFHMIHTGITSQGEVTHNLRDGIFHMIHTGITSQGEVTHNLRDGIFHMIHTGITSQGEVTHNLRDGIFHMIHTGITSQGEVTHNLRDGIFHMIHTGITSQGEVTHNLRDGIFHMIHTGRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BGZ9</accession>
    <name>A0A3S1BGZ9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_011708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000386">
        <property type="protein sequence ID" value="RUS80524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BGZ9"/>
    <dbReference type="STRING" id="188477.A0A3S1BGZ9"/>
    <dbReference type="OrthoDB" id="8964776at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS80524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="336" mass="37322" checksum="C95A9D8CFD0386B8" modified="2019-04-10" version="1" fragment="single">VYPLSFNSTVYPLSTSTVYPLSSTTTVYPLSFISAVYPLSSTTTVYPLSTTTVYPLFTTPTVYPLAFTPTVYPLSFTTTVYPLSFTTTVYPLSFTTTVYPLSFTTTVYPLSTTTVYPLFTTPTVYPLSSTPTVYPLSSTPTVYPLSFTPTMYPLSSTPTVYPLSSTPTLYPLPPNPYCLSTAPHPYCVSTVLYLYCRVVYPLSFNSTVYSLSFNSSVYSLSFNYSVYSLSFNSTVYPLFFNCSVYPLSFNSTVYLLSFNSTVYPLSFNSSVYPLFFNSTVYPLSCNSSVYPLSFNSTVYPLPFNSSVYSLSFICTVYSLSFNSTVHPLSSTHTVYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BJW9</accession>
    <name>A0A3S1BJW9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Farnesyl pyrophosphate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_006730</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pheromone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000167">
        <property type="protein sequence ID" value="RUS85522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BJW9"/>
    <dbReference type="STRING" id="188477.A0A3S1BJW9"/>
    <dbReference type="OrthoDB" id="10257492at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045337">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042811">
        <property type="term" value="P:pheromone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000021">
        <property type="entry name" value="Farnesyl pyrophosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01017">
        <property type="entry name" value="Polyprenyl_Transferase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS85522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="344" mass="39705" checksum="D68F75129614478E" modified="2019-04-10" version="1">MAKSELAEFDAVFSEIVEELTKSGLKLSETKDAYTWFKEVLVYNVPHGKKYRGVSVVSSYRRLAPNAKEEDLHIARILGWCVEMFQAFFLIADDIMDVSTIRRGQPCWYKKENVGFIAINDSFFLECAIYSLLRRYVKGKPYYMEVTELFLQTTLQTVVGQNLDLTTGPPQGKVDFTKFTMERYSAIVKWKTAFYSFYLPVALAMHMAGISDEESHVEAKRILLQMGHFYQVQDDYLDSYGDPEVVGKIGSDIEDNKCGWLVVTALELATEEQREQLKSCYGRPGEDDINKVKAIYKDLNLEKVYKDYEESSYQDLIKLINKTNCKVSPEVFTDFADKIYKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BKT8</accession>
    <name>A0A3S1BKT8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_022722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001657">
        <property type="protein sequence ID" value="RUS69517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BKT8"/>
    <dbReference type="OrthoDB" id="2286242at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS69517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="234" mass="26403" checksum="AA83C4DDDA5A6241" modified="2019-04-10" version="1">MDSNEIVSVVQGKIESRRSTGHPKPGLIDNIKDGPEKNRTEVFTNTERREQEDYTVDRSKDYPVLFSRAASIQSARVPRLLSQSVTYYSDVGDGIQEDYTVDRSKDYPVLFSRAASIQSARVPRLLSQSVTYYSDVGDGIFATPPAFPHQIRLVAQGDNGQGGEQGFKDLHRLADDCSYLSLKDELSRGRVLVRVRDDELPKALQAKQDLTQKLEKATLKQYLYVTELFKNHSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BLC1</accession>
    <name>A0A3S1BLC1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Ubiquitin-like modifier-activating enzyme ATG7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Autophagy-related protein 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_022454</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ATG7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001576">
        <property type="protein sequence ID" value="RUS69787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BLC1"/>
    <dbReference type="STRING" id="188477.A0A3S1BLC1"/>
    <dbReference type="OrthoDB" id="338614at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019778">
        <property type="term" value="F:Atg12 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019779">
        <property type="term" value="F:Atg8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01486">
        <property type="entry name" value="Apg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.70:FF:000001">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme atg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000243">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.100">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.70">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006285">
        <property type="entry name" value="Atg7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032197">
        <property type="entry name" value="Atg7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042522">
        <property type="entry name" value="Atg7_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042523">
        <property type="entry name" value="Atg7_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01381">
        <property type="entry name" value="E1_like_apg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF3">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16420">
        <property type="entry name" value="ATG7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like modifier-activating enzyme Atg7 N-terminal" evidence="9">
        <location>
            <begin position="5"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="8">
        <location>
            <begin position="332"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606285-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS69787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="688" mass="76088" checksum="4350442FA532C644" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BMQ3</accession>
    <name>A0A3S1BMQ3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_004978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000115">
        <property type="protein sequence ID" value="RUS87298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BMQ3"/>
    <dbReference type="STRING" id="188477.A0A3S1BMQ3"/>
    <dbReference type="OrthoDB" id="5860913at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000003">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS87298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="311" mass="35195" checksum="AE71677AC3D32CB2" modified="2019-04-10" version="1">MPFGLKNAAQAFQRLMDGILQNLRCCFVYLDDILVASSSPQEHEADLRSVFQSLAANGLVINTQKCLFGQPTMTFFDHKISQNGITPLPEKVKAIGEFPKANDKKASQRFLGMINFYHRFLPGIAKCLTPLTEATKSKSKAITWAVAFQAAKSALASATLLNHPDPKSETQFTTDIQYIIGTDNVVPDVLSRAIPNIEESMVASASPLPAIDLAQMAIEQPDNVYVRHDAHRGPFVRPYDVRPYDVRPYDVRPYDVRPYDVRPYDVRPYDVRPPDGPFQVLSRSDKQFDILKNKSPHEYLWQTQTRLFYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BMT7</accession>
    <name>A0A3S1BMT7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_004963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000115">
        <property type="protein sequence ID" value="RUS87283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BMT7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018526854" description="WAP domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS87283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="15667" checksum="2F9999A53C53A438" modified="2019-04-10" version="1">MSYTKRSGLSSLCVVALLLIGWFESFDAVILPPEVCAVSSTTYRLAGCIGKNNAFCRLLAFQLNFVFENDPLCVERPCTGFGTNTHECKGLLDCPLPRIFLPGVCNGLDICCRKADVDPSVDAEALEQADDMLDQVLGKLLGKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BN31</accession>
    <name>A0A3S1BN31_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_000231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000003">
        <property type="protein sequence ID" value="RUS92018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BN31"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS92018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="119" mass="13396" checksum="88445BF339BFA775" modified="2019-04-10" version="1">MPERIATCALSILTNHQVNTKDCEFKKKTTQNSIKPTDAGRVISSHSRFKSDLICNACSFDIIDSYASYVLVIGSTKDFVQHLTQCPRRATMFLDFVFSFFIPSEIGSANDDPKRKLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BN53</accession>
    <name>A0A3S1BN53_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_000271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000003">
        <property type="protein sequence ID" value="RUS92058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BN53"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS92058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="107" mass="12365" checksum="EFAE74DA6084FF14" modified="2019-04-10" version="1" fragment="single">QHPSAVGAGLNVCGRDQEKEEETRHHVERLSQLLRAERLNCREQAETIVSLRRLLDEHERRVHHMDSFSEGTTLRTGTAQFTRASPTQKLLDQVNRLQKQKTDLLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BQH4</accession>
    <name>A0A3S1BQH4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_019824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001070">
        <property type="protein sequence ID" value="RUS72419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BQH4"/>
    <dbReference type="OrthoDB" id="372487at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS72419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="28382" checksum="E1DA10555EDC835A" modified="2019-04-10" version="1" fragment="single">TQSSETLRPGKDSSKVDGPGTSNNSVATPSKRTEADAQPKSQADLALKQLLKIGVAQSGGSPVQDASLSPQPQPQPHVTTSSATPSAPAGQASPRSGGTTAELGTPTAYGRQVSLQELFEEANKQQQQQNQQQQQQQQPPQLNQPPPSLGGSHPVENRNPIAEVEAFCQAAFNNGEVHFDFKSQPKQNGFVATVSLPNGHKYDGSVCKTKQDASYSAASMALLCLKTSQGQATHPVITGSMPGAMPQRGPPMNRFFSPNSAFTAIGLQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BRZ2</accession>
    <name>A0A3S1BRZ2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_004923</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000114">
        <property type="protein sequence ID" value="RUS87311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BRZ2"/>
    <dbReference type="OrthoDB" id="10602354at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS87311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="695" mass="74062" checksum="800A9EF9C90C7D26" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BV30</accession>
    <name>A0A3S1BV30_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoporin Nup188 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_016677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000730">
        <property type="protein sequence ID" value="RUS75552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BV30"/>
    <dbReference type="STRING" id="188477.A0A3S1BV30"/>
    <dbReference type="OrthoDB" id="102511at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018864">
        <property type="entry name" value="Nucleoporin_Nup188_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044840">
        <property type="entry name" value="Nup188"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31431:SF1">
        <property type="entry name" value="NUCLEOPORIN NUP188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31431">
        <property type="entry name" value="NUCLEOPORIN NUP188 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10487">
        <property type="entry name" value="Nup188_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoporin Nup188 N-terminal" evidence="1">
        <location>
            <begin position="30"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS75552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="545" mass="62330" checksum="76C193CDF73696B0" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BYF1</accession>
    <name>A0A3S1BYF1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_014063</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000527">
        <property type="protein sequence ID" value="RUS78175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BYF1"/>
    <dbReference type="OrthoDB" id="8903066at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS78175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="178" mass="20223" checksum="8A2AD5FE8F1AD74F" modified="2019-04-10" version="1">MRIYPPKRTNTQNMEEIRVPKSNTAGMTSWSQLDPVHRTGNTDHWTKMKVRANTYRASYSAGGSVKVVPEHQVDQISSVKNPGERFKVDASQGSVTQLPPITFNDSVLNKLDRAPGDHDILTRPSRSMKKSWLDNCYQKRARDGFRYWLINRPKPTSFGKYGMGSYKMVMGIGMAPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BYM1</accession>
    <name>A0A3S1BYM1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_000106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000002">
        <property type="protein sequence ID" value="RUS92082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BYM1"/>
    <dbReference type="OrthoDB" id="6054172at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018750470" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS92082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="36931" checksum="BAA32072F6CCFC45" modified="2019-04-10" version="1">MEKGFILFVLAYIVVQINAQDAPLKVEFLDPSDRYVKLGDEVHLGFKLNRGLVFGVDNEALMERRRVVDGSEVVDVLSDIAKLEEAGVPEFYQVSVDKESADLTILFKILKVRDIDDATFMVRAIANNGEKANVSLKVIVLRENSKLKMKIGSNDFFSEKIEAPFSLDEGMYPVTCSAEGSNPATEDIMIWWNGEKLPLASTDKVLMDTPLQMYRTTVTAEVDVDLGTSGKLVECTATSRAGKQLHISAPIEVNVYDPEDLDGSEMKLDLTFHRVKQKNFGVWYLIITQKNGHMSKVPVKLNEIEGPSDSSSMLAASLVTLALCTVCALWKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1CAX4</accession>
    <name>A0A3S1CAX4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_004511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000102">
        <property type="protein sequence ID" value="RUS87765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1CAX4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS87765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="267" mass="30938" checksum="184A213BD34A9363" modified="2019-04-10" version="1">MELWVEALECSGDDWVELLEREKLSGARLGKVEGSNLRLGKKYGLYDNNDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDEDDDDDDDDDDDDDDDDDDDDEDDDDDDNDDDDDDDDDDDDDEDDNDDDDDDDDDDDDDEDDNDDDDDDDDDDDDDEDDNDDDDDDDDDDDDDEDDNDDDDDDDDDDDDDEDDDDDDNDDDDDDDDDDDDDEDDNDDDDDDDDDDDDDEDDNDDDDDDDDDDDDDEDDIYYIIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HN94</accession>
    <name>A0A3S1HN94_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TBC1 domain family member 23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_009435</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000270">
        <property type="protein sequence ID" value="RUS82815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HN94"/>
    <dbReference type="STRING" id="188477.A0A3S1HN94"/>
    <dbReference type="OrthoDB" id="73307at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099041">
        <property type="term" value="P:vesicle tethering to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20788">
        <property type="entry name" value="TBC1D23_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039755">
        <property type="entry name" value="TBC1D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045799">
        <property type="entry name" value="TBC1D23_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13297:SF5">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13297">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 23-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19430">
        <property type="entry name" value="TBC1D23_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="6">
        <location>
            <begin position="53"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="7">
        <location>
            <begin position="326"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="523"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS82815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="663" mass="73792" checksum="F846151AED768EDE" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HT90</accession>
    <name>A0A3S1HT90_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">E1A-binding protein p400 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_006584</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000163">
        <property type="protein sequence ID" value="RUS85638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HT90"/>
    <dbReference type="STRING" id="188477.A0A3S1HT90"/>
    <dbReference type="OrthoDB" id="372624at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031575">
        <property type="entry name" value="EP400_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15790">
        <property type="entry name" value="EP400_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E1A-binding protein p400 N-terminal" evidence="2">
        <location>
            <begin position="61"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS85638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="430" mass="45249" checksum="C7782A106183C955" modified="2019-04-10" version="1" fragment="single">MQQNDKETGGQPQQRLTTTGRFQALASLPAGRQATLIPAASGVGVPTLSLTLPRTLSGQESSAQALPVSAASLTSLVSPQTINLIQRQLSTGIVGLSTVSAQGLHLLQASGTPLTFVTATSPEAVTALEQRKARLLQQQKQQPGTVHHLAAPSPANPMSSPSHSLSIAATTMSGAQQTPSGLKRSHLSSDGTVILGTTLPTTGATISISAKDLKLLTQAKQPTCAVTTPATGGPSPKKIKLEAKPASNKETENCRQLVCSHKRNRMREIKRKYRNHLTELFYIQGGGNMTEFNSWKKRPSQPLLNFLEGSKLDSEDEDEPQEKKINDEIKVLTSAGSNAALATPAAISTTLPQSISALSQQGSSKPSALFSPLYTTTTCPNSLGSQAPGIDGFLRQLTAYIKGTGPKQSVAISRKPFTVLSCSMPASTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SIQ1</accession>
    <name>A0A433SIQ1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_023354</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001950">
        <property type="protein sequence ID" value="RUS68884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SIQ1"/>
    <dbReference type="STRING" id="188477.A0A433SIQ1"/>
    <dbReference type="OrthoDB" id="10261302at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="220"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS68884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="296" mass="31946" checksum="FAAAC43DC4539F05" modified="2019-05-08" version="1">MVRLRILEACKIGDMEKVQSDTAVHPDLVDKNGAGCLHYAARGGSLEIMKYLIKSAGFSPLQRSKTGSTALHDAAARGNTAVVKWLVEECTLNADDQDGVGITALHLAARYGHPLTVEWLLDEACADESIRTGSGAIPLFFAVVGGDLNCVKMLMDENPRLVNMQLNNGATPLYVACQNGLLDIAKYLHSRNGATKIKAYDGYRTNVQVGECNPNDRDFDGATPLHYAASRGHSEVVQWLLAHGGARVTLDNLGGSPLHSAAEMGELQYCTLSLPTPDENISKDYKFSGTFHKKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SJI1</accession>
    <name>A0A433SJI1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_022994</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001761">
        <property type="protein sequence ID" value="RUS69244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SJI1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS69244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="139" mass="15988" checksum="DAB90F870A72266E" modified="2019-05-08" version="1">MRILEITSKAAILRTGKPFDGMPLICFMHFGLIDSQENSYSTTSQHNTKQSSIITDLLSFIIKIDGMPLFCFMHFGLIDSQENSYSTTSQHNTKQSSIITDLLSYIIKMQNAFTFNLQKYYYQVIKSICFSRNSDEQQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SJI4</accession>
    <name>A0A433SJI4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_022974</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001754">
        <property type="protein sequence ID" value="RUS69260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SJI4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS69260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="133" mass="15296" checksum="E90EC4F215B567FB" modified="2019-05-08" version="1" fragment="single">NRILRPVLRTVCRIRNGPSLPALHHHDQRLLRPEARAVCRHSDFRFRPRSVGDVPAHRPVDRGVRLAGVLPHRGRDAPQPLRLLQSDETPGGQLQDVVQKQRGLLLLLLLHRYTGHRGIAQRIETHYRGQHDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SKJ4</accession>
    <name>A0A433SKJ4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_022726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001659">
        <property type="protein sequence ID" value="RUS69509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SKJ4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS69509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="189" mass="21467" checksum="032D30AB27B8ADC1" modified="2019-05-08" version="1">MGLFAQCGPHGTICSMWPTWDYLLNVAHMGLFAQCGPHGTICSMWPTWDYLLNVAHMGLFAQCGPHGTICSMWPTWDYLLNVAHMGLLSGRKKTETICTMWPTWDYLHNVAHMELFAQCGPHGTICTMWPTWNYLHNVAHMELFVQCGPHGTICTMWPTWDYLHHGTSSDQMLQPINPFFADLDPDPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SL42</accession>
    <name>A0A433SL42_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleolar GTP-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_022387</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with LYAR and RPL23A. Interacts with the nuclear importin-beta receptor and, at a lower extent, with importin-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
            <location evidence="1 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001556">
        <property type="protein sequence ID" value="RUS69848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SL42"/>
    <dbReference type="STRING" id="188477.A0A433SL42"/>
    <dbReference type="OrthoDB" id="444945at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01858">
        <property type="entry name" value="NGP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000559">
        <property type="entry name" value="Nuclear/nucleolar GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1580.10:FF:000001">
        <property type="entry name" value="Nucleolar GTP-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024929">
        <property type="entry name" value="GNL2_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012971">
        <property type="entry name" value="NOG2_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF9">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08153">
        <property type="entry name" value="NGP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="9">
        <location>
            <begin position="205"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00065814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS69848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="484" mass="54728" checksum="2E01A4AB63808441" modified="2019-05-08" version="1" fragment="single">MGKPKAKQQRDRVNKAGHSMNPDRPKTSAGMRDRTTIRRLQMYRNFKAKRDASGKIVKAAPFQSTLKSGTMARVEPNRKWFGNTRVVTQNALQAFNEAMGKVKSDPYKVVMNPTKNPVTLLSYTPKAASAPRLLDTEPFEKVFGKKATRKKPTLDTYDLNEMVKKANEDLAKWEETQGLPVPGEDWVKDEQLEIVFKAGTSKRIWNELYKVIDSSDVLLQVLDARDPNGTRCMQVENYLKKEKPHKHLIFVLNKADLVPNWAVKKWVAVLSAIRPTMAFRASITNCFGKGDLISLLRQFGKLHQDKKQISVGLIGYPNVGKSSIINALKSKKVCNVAPIPGETKVWQYVTLMNNLFLIDCPGVVYPYGATPTDMVLKGVVRVEKVKQPEDYVHAVLDRVKEEYLQKTYGVTKWETPEDFLEQVARKCGRLLKGGEADISTVAKNVLNDYQRGKIPYFVRPPESEVCQDKGVIFILYKLGSRSYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SL82</accession>
    <name>A0A433SL82_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_022338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001543">
        <property type="protein sequence ID" value="RUS69897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SL82"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS69897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="182" mass="20740" checksum="987BCBFD5EA430C0" modified="2019-05-08" version="1" fragment="single">NLCNSKSFIPNFLPLLQISPSYSNIRAIIFPSLFPRQQLFILEKFFFHPSHNLVDGLSLHIQGISPPHSTPFPLQSLQLQIFLPRFLALVSNSPSYLTFFPSLFPRQQLFILEMFLSLSQSCRFPLQSLQLQIFLARFLALVCGSCCVLEYPCPSATSLGPARRNRREIRRPHRLDHGGRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SM66</accession>
    <name>A0A433SM66_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Retrovirus-related Pol poly from transposon TNT 1-94</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">EGW08_021985</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">EC2010</strain>
            <tissue evidence="22">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001450">
        <property type="protein sequence ID" value="RUS70255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SM66"/>
    <dbReference type="STRING" id="188477.A0A433SM66"/>
    <dbReference type="OrthoDB" id="6158475at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0229">DNA integration</keyword>
    <keyword evidence="16" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="14" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="15" id="KW-0917">Virion maturation</keyword>
    <keyword evidence="18" id="KW-0862">Zinc</keyword>
    <keyword evidence="18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="20">
        <location>
            <begin position="239"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="21">
        <location>
            <begin position="521"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="748"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1107"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="1125"/>
            <end position="1134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="RUS70255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="24">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1140" mass="129952" checksum="4D3A4784525052A3" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SQ86</accession>
    <name>A0A433SQ86_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SMB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_020843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001221">
        <property type="protein sequence ID" value="RUS71388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SQ86"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.20">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019038010" description="SMB domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS71388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="24342" checksum="CBB8F4E7C2D8ABB2" modified="2019-05-08" version="1">MCLGKYFRHFLLLVALMVTTNCNRTDTEDTVIKKETILDDPIGAERNASLPLEPVELQSSFEAVPLEPDGLQLESSFQVVPEEPENITPITPEEVIIVEKPIEVTIVEQIPTQHRLEMPRLMTPLQEVGTPETPLVDKIIMIDSDVCGGYCHGSYPYNYRPPRWNMCQTCHCDAMCHFYRDCCPDVLLKQNVTYDETPRVVDCVVKKAVVYDPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433STC2</accession>
    <name>A0A433STC2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_019729</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001060">
        <property type="protein sequence ID" value="RUS72501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433STC2"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS72501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="121" mass="15455" checksum="28B0C10179D3B8A7" modified="2019-05-08" version="1" fragment="single">SVGCRFYNVYRQQWVVGCRFYNVYRQQWVVGCRFYNVYRQQWVVGCRFYNVYRQQWVVGCRFYNVYRQQWVVGCRFYNVYRQQWVVGCRFYNVYRQQWVVGIRFYNVYRQQWVVGCRFYNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433STC8</accession>
    <name>A0A433STC8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_019722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001059">
        <property type="protein sequence ID" value="RUS72513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433STC8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS72513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="108" mass="12394" checksum="39979BAFC52E73D0" modified="2019-05-08" version="1">MCYKTGRRDLLCATRQTSNSSMCYKTGRRDLLCATRQGGETSYVLQDRAERPPMYYKTGRRDLLCATRQGGETSYVLQDRAERPPMCYKTGRRDLCCRSCLTDTEPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SUF0</accession>
    <name>A0A433SUF0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_019337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001002">
        <property type="protein sequence ID" value="RUS72902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SUF0"/>
    <dbReference type="OrthoDB" id="6085892at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS72902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="561" mass="63500" checksum="ECC14F52F19D301A" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SUI7</accession>
    <name>A0A433SUI7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_019278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000993">
        <property type="protein sequence ID" value="RUS72961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SUI7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002038">
        <property type="entry name" value="Osteopontin"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00216">
        <property type="entry name" value="OSTEOPONTIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS72961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="208" mass="24918" checksum="2CEE0257F6D1EC93" modified="2019-05-08" version="1">MESLVLQRVEGSGGGDGDDDDEEEENEEEEEDADDEDDDDDDDDDDDDDDDDDDDDEDDDDDDDDEEEEEEEEDDGDDYGDDDDDDDDDDDDDDDDDDDDDDDGDGITHQENRQEEKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKILCEKVEEKEEEKEEEEEEEEEEEEEEEEEEEEEEKRSCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SX30</accession>
    <name>A0A433SX30_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein xylosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_018377</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000893">
        <property type="protein sequence ID" value="RUS73855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SX30"/>
    <dbReference type="STRING" id="188477.A0A433SX30"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008375">
        <property type="term" value="F:acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003406">
        <property type="entry name" value="Glyco_trans_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19297">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 14 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19297:SF191">
        <property type="entry name" value="PROTEIN XYLOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02485">
        <property type="entry name" value="Branch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS73855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="517" mass="59829" checksum="5A30D2399E873168" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T3C1</accession>
    <name>A0A433T3C1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_016181</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000690">
        <property type="protein sequence ID" value="RUS76051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T3C1"/>
    <dbReference type="STRING" id="188477.A0A433T3C1"/>
    <dbReference type="OrthoDB" id="197676at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043451">
        <property type="entry name" value="Myocardin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004018">
        <property type="entry name" value="RPEL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22793:SF12">
        <property type="entry name" value="MYOCARDIN-RELATED TRANSCRIPTION FACTOR, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22793">
        <property type="entry name" value="MYOCARDIN-RELATED TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02755">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00707">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51073">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="repeat" description="RPEL" evidence="7">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="7">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="7">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="10">
        <location>
            <begin position="570"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="196"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="289"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="513"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="764"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="849"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="992"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="292"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="333"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="768"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1098"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS76051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1098" mass="115218" checksum="BF2C13266DF8E365" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T3Q8</accession>
    <name>A0A433T3Q8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Somatostatin/Cortistatin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_016052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000682">
        <property type="protein sequence ID" value="RUS76174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T3Q8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019228927" description="Somatostatin/Cortistatin C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="37"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS76174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="139" mass="15164" checksum="AD0F1618C276412B" modified="2019-05-08" version="1" fragment="single">MMDSGMAATFSQTPVALVTASLSVLLALGLVGQTLALEPSDDLAYRPNFFQQMSRQPQSGGLEERAVPGQSMEKLSKLLSVKDWMSELFVPGQGAQSGDVQPPQDKRVFCNGFTGCGGRFRKQRRRQDRDGDRKRAAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T4Q0</accession>
    <name>A0A433T4Q0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Retinol dehydrogenase 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_015718</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000656">
        <property type="protein sequence ID" value="RUS76525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T4Q0"/>
    <dbReference type="STRING" id="188477.A0A433T4Q0"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004846">
        <property type="entry name" value="PRK06197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS76525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="37209" checksum="E02430955CF4DF8D" modified="2019-05-08" version="1">MLELSGLVFPVITVLSLVACLHLYYGQLTVKSGVVISAVFVGLAIVREWSSGGFYHGTDRIPGKTVVITGANTGIGKQTARDLARRGGRIILACRDVVKGEAAAREIIRDTGNNNVFCWKLDLSSFESIREFANKFNDNEPRLDVLINNAGIMLCPHMLTKDGLEMQIGVNHFGHFLLTNLLMDKLKSSSPSRIVIVSSLAHRAGVINFEDLNSEKSYGRVSAYCQSKLANILHALELTKRLEGTGVTANSLHPGAVDTELGRYLVTGLPKVMLASILAPFVKSPAQGAQTSIRLAVDPSLETVSGKYFSDCKDTKTSAAALDENVAKRLWEVSEKITNSTYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T5I3</accession>
    <name>A0A433T5I3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_015411</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Neuron projection</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000632">
        <property type="protein sequence ID" value="RUS76825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T5I3"/>
    <dbReference type="STRING" id="188477.A0A433T5I3"/>
    <dbReference type="OrthoDB" id="2414723at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22204">
        <property type="entry name" value="H1_KCTD12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057093">
        <property type="entry name" value="H1_KCTD8_12_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499:SF136">
        <property type="entry name" value="GH08630P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23110">
        <property type="entry name" value="H1_KCTD8_12_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Potassium channel tetramerisation-type BTB" evidence="8">
        <location>
            <begin position="11"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="KCTD8/12/16 H1" evidence="9">
        <location>
            <begin position="134"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS76825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="254" mass="28637" checksum="2EF1F48A4551D925" modified="2019-05-08" version="1">MNDTSNNSVLELNVGGVFYSTNLGTLRREPDSLIARLFADHSNVKAVKDAKGKYFIDRDGVLFRYILDYLRNLKLVLPENFHEKDRLKQEAEFFSLPNLVKIIDASSTRKSRLGAGDESGLSPSPSPLGERGSGFITVGYRGTFAFGKEGLADVKFRKLTRIIVCGKVSLCKEVFKDTLNESRDPDRGDSDRYTSRFFLKHTFLEQAFDMLQDEGFALVASCGSGTNSAGELKPGLDTEEARWYHYNEFIFERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T5T3</accession>
    <name>A0A433T5T3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_015299</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000622">
        <property type="protein sequence ID" value="RUS76950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T5T3"/>
    <dbReference type="STRING" id="188477.A0A433T5T3"/>
    <dbReference type="OrthoDB" id="6080945at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF372">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="38"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="58"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS76950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="275" mass="30516" checksum="F027066ACFC8EAA8" modified="2019-05-08" version="1">MSNGSDFLALSMSSSTNQTGRGSCTLLDPLVSVALMDIFLMVNDFVLCSLLSFLGVFTNIANIVVYARMGLSETSKINFLALSVLDFFVSLVTFFLKFLYSPVLKHLSTGPITTRISTSLSPPMLCTIGASAMMTALISTERCLCVVFPLKVKMFLTPRRVLYLLLTIVAYMVTFLLVFYIDVGAPFINQIGKQVFYLLCFFALPSTTCFLIVVLSTIFLVVQLRKNLKWRMERSSQSAESICKENKLVLMFQVPILVLVSVVKRVVGTPASLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TBN3</accession>
    <name>A0A433TBN3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_013261</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000479">
        <property type="protein sequence ID" value="RUS78959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TBN3"/>
    <dbReference type="STRING" id="188477.A0A433TBN3"/>
    <dbReference type="OrthoDB" id="1724672at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="419"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="210"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS78959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="882" mass="96589" checksum="95EC26E537FFD4DD" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TCR3</accession>
    <name>A0A433TCR3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_012866</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000455">
        <property type="protein sequence ID" value="RUS79375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TCR3"/>
    <dbReference type="STRING" id="188477.A0A433TCR3"/>
    <dbReference type="OrthoDB" id="1551503at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050673">
        <property type="entry name" value="Mito_inner_translocase_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13172">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0811">Translocation</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="9">
        <location>
            <begin position="19"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS79375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="93" mass="10538" checksum="6F6EDC4E12266353" modified="2019-05-08" version="1">MAQANLPTQMQIDAASTGSQFREFLSQYNKITEQCFMACVHDFTTRKVVNEENSCALHCLEKFMKMTNRISQRFQEHQMATNDALAAAAQKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TDV8</accession>
    <name>A0A433TDV8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ADP-ribosylation factor-like protein 15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_012456</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000428">
        <property type="protein sequence ID" value="RUS79772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TDV8"/>
    <dbReference type="STRING" id="188477.A0A433TDV8"/>
    <dbReference type="OrthoDB" id="414781at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042292">
        <property type="entry name" value="ARL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46693">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46693:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS79772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="24648" checksum="6F859861B6CD7950" modified="2019-05-08" version="1">MCESIRIVCALCRVGIYALYRRLCCKGPSPVRPNFSILCIGLENAGKSSILSCLSGDDLHKIEPTIGFSIKAVLFEDCILEVKELGGGDKVRPYWDRYYQVFQGIIFVIAGDDSDEKLNVAREELLKAARHHQLKGLPLLILVSHQDKEGAKTAEEMMTFLQLGTEMENRQFLIKGCSIHNKEELSQIFAQFNEILQKNLDHDIELRKNSPQHSGNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TDW8</accession>
    <name>A0A433TDW8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_012491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000430">
        <property type="protein sequence ID" value="RUS79746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TDW8"/>
    <dbReference type="STRING" id="188477.A0A433TDW8"/>
    <dbReference type="OrthoDB" id="3549872at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS79746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="196" mass="22959" checksum="9210A0EEDBDFC3D4" modified="2019-05-08" version="1" fragment="single">MSELTRQQLEDEIVSLTKDKQEVIAQLNQLSRQKQALAEELLTTRREVERLQVSLERISKEKEALTNEKGELVVQVTACERENRQQSEMISAYAADKDSLESALYEAQQMVRELEVKRAQLEGENQELIVKKENLQSEIVRLEQEKATDFERFEYAKESLNQRLHQLDRDSQLALSQEKQAHEEDVERLSQERDTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TF26</accession>
    <name>A0A433TF26_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_012083</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the vinculin/alpha-catenin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000408">
        <property type="protein sequence ID" value="RUS80160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TF26"/>
    <dbReference type="STRING" id="188477.A0A433TF26"/>
    <dbReference type="OrthoDB" id="29742at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.810">
        <property type="entry name" value="Vinculin, Vh2 four-helix bundle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036723">
        <property type="entry name" value="Alpha-catenin/vinculin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006077">
        <property type="entry name" value="Vinculin/catenin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18914">
        <property type="entry name" value="ALPHA CATENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18914:SF30">
        <property type="entry name" value="VINCULIN_ALPHA-CATENIN FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01044">
        <property type="entry name" value="Vinculin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47220">
        <property type="entry name" value="alpha-catenin/vinculin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS80160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="149" mass="16389" checksum="E58BA6D9BCEE1954" modified="2019-05-08" version="1" fragment="single">MSSACESLVVACDQLTILAQRFGNNVARSSGIKDSLCQAAKDVLQGVLKIFLVIDDHYVRQILGKVDFVQRKVADVLRASKSQLVDVFKCLTFSVLALKTELKKRCSNLLSAACREQILVWSGVLQNSVASLSLATQTRLKYRDNLAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TGL1</accession>
    <name>A0A433TGL1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-mRNA polyadenylation factor Fip1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_011502</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000375">
        <property type="protein sequence ID" value="RUS80738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TGL1"/>
    <dbReference type="STRING" id="188477.A0A433TGL1"/>
    <dbReference type="OrthoDB" id="1917198at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007854">
        <property type="entry name" value="Fip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051187">
        <property type="entry name" value="Pre-mRNA_3'-end_processing_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13484">
        <property type="entry name" value="FIP1-LIKE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13484:SF0">
        <property type="entry name" value="PRE-MRNA 3'-END-PROCESSING FACTOR FIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05182">
        <property type="entry name" value="Fip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-mRNA polyadenylation factor Fip1" evidence="6">
        <location>
            <begin position="141"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="261"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="292"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="347"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="374"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="506"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS80738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="546" mass="62291" checksum="DCF8CDDD4AFF98FC" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TIQ3</accession>
    <name>A0A433TIQ3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_010766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000336">
        <property type="protein sequence ID" value="RUS81468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TIQ3"/>
    <dbReference type="OrthoDB" id="6144763at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS81468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="24977" checksum="E408A7E53049D42B" modified="2019-05-08" version="1">MSDADDDSRSSLTASAGRGSNSGCSSGAETDDFQRSFDCAEQELLYVSRHGKRSRLLSMLVASEEADEVDKLNINCKGGTLWSLVKSTRKYRMAFRGPVLVYLANHAEGKRASSIERCGGFRASASNAGEIPNEVAYADDVDFIGQSYADINKIQEVLKKYQLKVNTDKTEYTSLSKSEEGWKEVKKVGSLIDDDKDVERRKQLATAALNKLNNVWIKGNKTENLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TJH6</accession>
    <name>A0A433TJH6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_010582</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000325">
        <property type="protein sequence ID" value="RUS81665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TJH6"/>
    <dbReference type="STRING" id="188477.A0A433TJH6"/>
    <dbReference type="OrthoDB" id="1478556at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.250:FF:000002">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1550.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_uL11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="8">
        <location>
            <begin position="13"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="7">
        <location>
            <begin position="74"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS81665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="165" mass="17982" checksum="C467058060F514A7" modified="2019-05-08" version="1">MPPKFDPNAVFTVYCRAVGGEVPATSSLAPKIGPLGLSPKKIGDDIQKGTADWKGLKITVKLIVQNRQAKVEVVPSAAALIIRALKEPPRDRKKVKHVKHNGNITMDDIMKIARQMRSRSMAKELSGTVKEILGTAQSIGCTIDKQAPHTVIERINNGEVEIPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TJN3</accession>
    <name>A0A433TJN3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_010456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000321">
        <property type="protein sequence ID" value="RUS81764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TJN3"/>
    <dbReference type="STRING" id="188477.A0A433TJN3"/>
    <dbReference type="OrthoDB" id="2134133at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS81764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="158" mass="17940" checksum="ED6C0ECEBFD42C00" modified="2019-05-08" version="1">MSGDLLPTSPAPFHRNRILPPLEVERRKPHQSYRATSAIDNKDTRLLSFRDRPHDLAEQARPNTTHAMRSETPYGNTLNRRSSTPLGNTITARNTLLANKSLDVRGNSLQPGDTSHFHPDIQEDQQESPGEEIYRTHWNAAHGMNPRRNRAAHILGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TK80</accession>
    <name>A0A433TK80_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_010342</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000315">
        <property type="protein sequence ID" value="RUS81915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TK80"/>
    <dbReference type="OrthoDB" id="6073803at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF18">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS81915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="300" mass="33482" checksum="78727174E7DB7369" modified="2019-05-08" version="1">MGFSSPSTISLFCLSITDTYCLFHISLTSFGLLPWVRDADLPIALLDVAYILSAVRFSVAATGSWITAVINVERSCCVVFPMKVKSIFTRKTIIGLIAGMVVYQVLATLPRSLSLHMTSFKSRWSNRTVYKLDRTKLDERVANATLMAASAIPTFFCFFVVVFGTIFLIYSFKKSRALRDAMTKSKTGPTENTGSGEGSKLDTGSKMSEKDLRLIRSVIAISSIYIGGETPNILIILATTFYPPFSLKNPYLHNFASALVMTGHFCQAISFSVNFFVYFNMSSKFKQTFKEIFPCCWRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TKK0</accession>
    <name>A0A433TKK0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_010137</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000303">
        <property type="protein sequence ID" value="RUS82092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TKK0"/>
    <dbReference type="STRING" id="188477.A0A433TKK0"/>
    <dbReference type="OrthoDB" id="10052615at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056737">
        <property type="entry name" value="Beta-prop_ATRN-MKLN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052456">
        <property type="entry name" value="CTLH_complex_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010565">
        <property type="entry name" value="Muskelin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15526">
        <property type="entry name" value="MUSKELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15526:SF5">
        <property type="entry name" value="MUSKELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24981">
        <property type="entry name" value="Beta-prop_ATRN-LZTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06588">
        <property type="entry name" value="Muskelin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Muskelin N-terminal" evidence="3">
        <location>
            <begin position="32"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Attractin/MKLN-like beta-propeller" evidence="4">
        <location>
            <begin position="378"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS82092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="751" mass="87296" checksum="536EBC48938BDFBB" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TMC9</accession>
    <name>A0A433TMC9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">KH homology domain-containing protein 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Brings lots of money 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_009519</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">RNA-binding protein involved in pre-mRNA splicing. Interacts with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome. Involved in regulating splice site selection. Binds preferentially RNA with A/C rich sequences and poly-C stretches.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the KHDC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000274">
        <property type="protein sequence ID" value="RUS82739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TMC9"/>
    <dbReference type="STRING" id="188477.A0A433TMC9"/>
    <dbReference type="OrthoDB" id="397265at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22385">
        <property type="entry name" value="KH-I_KHDC4_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22386">
        <property type="entry name" value="KH-I_KHDC4_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000037">
        <property type="entry name" value="KH domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047890">
        <property type="entry name" value="KHDC4_KH-I_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047889">
        <property type="entry name" value="KHDC4_KH-I_second"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056149">
        <property type="entry name" value="PRP5/DDX46/KHDC4_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031121">
        <property type="entry name" value="RIK/BLOM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15744">
        <property type="entry name" value="BLOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15744:SF0">
        <property type="entry name" value="KH HOMOLOGY DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23469">
        <property type="entry name" value="KH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent RNA helicase PRP5/DDX46/KHDC4 KH" evidence="7">
        <location>
            <begin position="56"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="KHDC4/BBP-like KH-domain type I" evidence="6">
        <location>
            <begin position="218"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="143"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="427"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="484"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="580"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="643"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="706"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1048"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="428"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="450"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="489"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="590"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="646"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="737"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="792"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="834"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1055"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1127"/>
            <end position="1142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00045732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS82739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1161" mass="124900" checksum="54FBAEEFDFF76CA6" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TMT0</accession>
    <name>A0A433TMT0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_009392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000268">
        <property type="protein sequence ID" value="RUS82870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TMT0"/>
    <dbReference type="STRING" id="188477.A0A433TMT0"/>
    <dbReference type="OrthoDB" id="8960535at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS82870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="176" mass="20113" checksum="F56543BD9990D65C" modified="2019-05-08" version="1" fragment="single">IPQRTVQIKSIVQIKSIVRIKSIVQIKSIVRIKSIVQIKSIVRIKSIVQIKSIVRIKSIVQIKSIIPQRTVQIKSIVQIKSIVRIKSIVQIKSIVQIKSIVRIKSIVRIKSIVQIKSIVQIKSIVRIKSIVQIKSIVQIKSIVRIKSIVRIKSIVRIKSIIQIKVIVQIKSATKHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TN69</accession>
    <name>A0A433TN69_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_009227</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000262">
        <property type="protein sequence ID" value="RUS82990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TN69"/>
    <dbReference type="STRING" id="188477.A0A433TN69"/>
    <dbReference type="OrthoDB" id="6352355at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09388">
        <property type="entry name" value="LIM1_LMO1_LMO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09390">
        <property type="entry name" value="LIM2_dLMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000015">
        <property type="entry name" value="LIM domain only 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000016">
        <property type="entry name" value="LIM domain only 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050945">
        <property type="entry name" value="LMO_RBTN_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45787">
        <property type="entry name" value="LD11652P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45787:SF1">
        <property type="entry name" value="LIM ZINC-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="65"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="129"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS82990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="216" mass="24431" checksum="A15343272906AB07" modified="2019-05-08" version="1" fragment="single">MAGSKESSPPCLEPVTTDDDDLHEMPTLEIQTNLDLADELHDHTGPVPMSGEEMSPALMKPANQQECMACKKPITDRFFLKTMDQYWHEDCLKCSCCDCRLGEVGSTLFSKANLLLCRRDYLRLFGTTGYCAACKKMIPAFEMVMRAKNNVYHLECFACQQCMHRFCVGDRFYLVDNKILCEFDYEERMMFANLGGSSNHQTNSMPNGLSNGMPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TPX6</accession>
    <name>A0A433TPX6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_008621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000236">
        <property type="protein sequence ID" value="RUS83653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TPX6"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS83653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="128" mass="15599" checksum="4BE776AAC73B9A6A" modified="2019-05-08" version="1">MLLIFLIKFNKIFKVSPQNLCFLQIRMLLFFPFCNIIYMDILSRRAIRSQHRSRFSNLYFSRRLIIISYKTTYFWQSTDRECFKITFLFLACNMFSIVCICTCIRKLKSILDDIMKDSVLFFLYNLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TS39</accession>
    <name>A0A433TS39_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cullin-4B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">EGW08_007857</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">EC2010</strain>
            <tissue evidence="19">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15 16">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000207">
        <property type="protein sequence ID" value="RUS84395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TS39"/>
    <dbReference type="STRING" id="188477.A0A433TS39"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031464">
        <property type="term" value="C:Cul4A-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031465">
        <property type="term" value="C:Cul4B-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000003">
        <property type="entry name" value="Cullin 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000001">
        <property type="entry name" value="Cullin 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000050">
        <property type="entry name" value="Cullin 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000004">
        <property type="entry name" value="Cullin 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000008">
        <property type="entry name" value="Cullin 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000059">
        <property type="entry name" value="Cullin-4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="18">
        <location>
            <begin position="452"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RUS84395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="806" mass="93561" checksum="09CDBD36C4AEDC56" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TSM0</accession>
    <name>A0A433TSM0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_007687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000202">
        <property type="protein sequence ID" value="RUS84518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TSM0"/>
    <dbReference type="STRING" id="188477.A0A433TSM0"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019136045" evidence="1">
        <location>
            <begin position="26"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS84518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="206" mass="24804" checksum="D3FC51C914A24258" modified="2019-05-08" version="1" fragment="single">MWANHSHSEWWMVLGPSLWARHCHSEWWMVLVSSLWANHCHSEWWMVLGSSLWANHCHSEWWMVLGSSLWARHCHSEWWTVLGSSLWIKHCHSEWWTVLGSSLWARHCHSEWWMVLGSSLWAKHCHSEWWMVLGSSLWVVLGSSLWAKHCHSEWWTVLGSSVWASHCHSEWWTVLGSSLWIKHCHSEWWMVLGSSLWIKHCHSEWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TTY8</accession>
    <name>A0A433TTY8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_007206</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="RQTK01000185">
        <property type="protein sequence ID" value="RUS85022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TTY8"/>
    <dbReference type="STRING" id="188477.A0A433TTY8"/>
    <dbReference type="OrthoDB" id="2573163at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000828">
        <property type="term" value="F:inositol hexakisphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF21">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="541"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="551"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS85022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="717" mass="78130" checksum="11F3E75F1D784C42" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TUY4</accession>
    <name>A0A433TUY4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">calcium/calmodulin-dependent protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_006837</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.17" evidence="2"/>
    <dbReference type="EMBL" id="RQTK01000171">
        <property type="protein sequence ID" value="RUS85394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TUY4"/>
    <dbReference type="STRING" id="188477.A0A433TUY4"/>
    <dbReference type="OrthoDB" id="442176at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000009">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000001">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type II subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013543">
        <property type="entry name" value="Ca/CaM-dep_prot_kinase-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08332">
        <property type="entry name" value="CaMKII_AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS85394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="426" mass="47662" checksum="508DE79514B6F6E3" modified="2019-05-08" version="1" fragment="single">VRLHDSIQDEGFHYLVFDLVTGGELFEDIVAREFYSEADASRCIQQVLEGINSCHQHSIIHRDMKPENLLLASKAKGAAVKLADFGLAIEVQGEQNAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVVLYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVTPEAKNLINSMLNTNPNKRINAAEALKHPWICQRERVASVVHRQETVDCLKKFNARRKLKGAILTTMLATRNFSSNAASSSAGNGPLLAPSIASTLGRSLNVKKNDAIKESTESNTLEDEDSKGRKQEIIKLTEQLLQAITSGDYGEYTKLVDPHLTSFEPEALGNLIVGLDFHKFYFDHVLSKNNKPVNTSILNPHVHLLGEDAACIAYVRLTQLIDRNGLPVTYHAEETRIWQRKDSKWQNVHFHRSGSPSGEQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TWP5</accession>
    <name>A0A433TWP5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_006286</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000155">
        <property type="protein sequence ID" value="RUS85957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TWP5"/>
    <dbReference type="STRING" id="188477.A0A433TWP5"/>
    <dbReference type="OrthoDB" id="2193432at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07981">
        <property type="entry name" value="HFD_TAF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000011">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037794">
        <property type="entry name" value="TAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003228">
        <property type="entry name" value="TFIID_TAF12_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264:SF21">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03847">
        <property type="entry name" value="TFIID_20kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 12" evidence="8">
        <location>
            <begin position="117"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="83"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS85957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="218" mass="23167" checksum="3C77C14042F6C72C" modified="2019-05-08" version="1">MSSYQNNLNSSAQLNGLSATSTPSTSPAPSFAGNGGSSIVSVLSNGPSSSPVTMPVTGSPVAARSSQPEQIIVPVGNVMNSASKASASSNSQASHAASNSSPAAAGASDNRGVLDRTRLRELVKEVDPLEQMDDDVEDVLLQVADDFIENVVASSCQLAKHRRSNTLEAKDVQLYLERSWNMQIPGFGSDEIRPYKKALTTEAHKQRMALIRKTMKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U1E2</accession>
    <name>A0A433U1E2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_004600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000105">
        <property type="protein sequence ID" value="RUS87615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U1E2"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS87615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="229" mass="25693" checksum="D352E0F06B48BF00" modified="2019-05-08" version="1">MLGRQALSDFVALFVVGQHFHQAWEGVTPSLDHQCCSFYAHSDNGYMYSASRPHTAIYTHAARDGMVSSDARLTAGAWYGQDGIFNGNAINHEPIVLRRVRFQIQRATDKLFRFGIVGKHTGLPSAQCSSFDMTNVSNIQPKYLSLSTTEDDYGDDDEDDDDDDDDDDDDDDDDDDDDDDDDDDDGDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDADDDDDDDAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U1S4</accession>
    <name>A0A433U1S4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">28S ribosomal protein S36, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_004436</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-ketoglutarate dehydrogenase component 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000101">
        <property type="protein sequence ID" value="RUS87771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U1S4"/>
    <dbReference type="STRING" id="188477.A0A433U1S4"/>
    <dbReference type="OrthoDB" id="2116030at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020373">
        <property type="entry name" value="Kgd4/YMR-31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31601">
        <property type="entry name" value="28S RIBOSOMAL PROTEIN S36, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31601:SF2">
        <property type="entry name" value="ALPHA-KETOGLUTARATE DEHYDROGENASE COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10937">
        <property type="entry name" value="Kgd4-YMR31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="30"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS87771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="11306" checksum="3F7E108AC9277723" modified="2019-05-08" version="1">MPSLPFIARSSNTMMASVAARTTQAIRPHVPLIKFPPRNAVPSHSNAPKGATSHPAPTPNSTHQAPASSKAISKGATIESSSLPFKYQRKPISMEEMEYIEKGGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U2Q6</accession>
    <name>A0A433U2Q6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_004154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000093">
        <property type="protein sequence ID" value="RUS88101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U2Q6"/>
    <dbReference type="OrthoDB" id="10678453at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="630"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="861"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="393"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="699"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="732"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="746"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="764"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="862"/>
            <end position="883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS88101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="922" mass="100494" checksum="6E805EB3DF241B26" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U3T9</accession>
    <name>A0A433U3T9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_003744</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000081">
        <property type="protein sequence ID" value="RUS88486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U3T9"/>
    <dbReference type="OrthoDB" id="6377161at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505:SF8">
        <property type="entry name" value="DPT-YFP REPRESSOR BY OVEREXPRESSION, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="11"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS88486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="261" mass="31143" checksum="168F1F428D71E32E" modified="2019-05-08" version="1">MTSWNRESLLDFIRIYKEEECLWRVKSDGYHDKEKCEKSYQRLLLFMRQQYPGAQKDDIRRKIKNLRTVFRKEEKQVKDALLSGAVYSPRLWYYKELEFLTDQEEGRSSVSSMSQKQNKDVQHVPSHEHLMNNDRIKDDDHEYDYEPPLGEHAFSDSDMDESNQSYTTYDTSVQQQNSRERTAMKRKRDHDYRHAEVKQMLADYKGPKSDKFDTFGQYVSHSLRQMSAEQYIHTQKLIADALYEGQLGNLSRRSRLLADPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U703</accession>
    <name>A0A433U703_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-rRNA-processing protein TSR2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_002615</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in 20S pre-rRNA processing.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TSR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000051">
        <property type="protein sequence ID" value="RUS89597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U703"/>
    <dbReference type="STRING" id="188477.A0A433U703"/>
    <dbReference type="OrthoDB" id="263560at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019398">
        <property type="entry name" value="Pre-rRNA_process_TSR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21250">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10273">
        <property type="entry name" value="WGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="149"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="181"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS89597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="224" mass="25269" checksum="9BA5F61F92A328D3" modified="2019-05-08" version="1" fragment="single">KLTQKAKRDWISRPEKKPLWLKTSYRPSCSTNMAASIQPSIFGVALTRILDSWTALQLAVQQGFGGPESAEKAQWMVHAIETWFNENEGLETYEVEEFLENVLNTEFDLLLEDNSTQEIARLICTYYRLCQEKKLDELEQRLQLLPRPAVNSCRSGGEQLEFDSSDETAQGPAFSNHSSDPPSTAQTSQAPSTSSAGNVDSMETEEQAQEDSDGWQVMRRGKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U8R0</accession>
    <name>A0A433U8R0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_002081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000038">
        <property type="protein sequence ID" value="RUS90202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U8R0"/>
    <dbReference type="STRING" id="188477.A0A433U8R0"/>
    <dbReference type="OrthoDB" id="9634265at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS90202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="149" mass="17509" checksum="65CAC8E3C1EEBB1C" modified="2019-05-08" version="1" fragment="single">PIGRPTLYQLSQFKLSYSSTDLDFSSPSYSSIDLDFTRPSHFSTELDFTRQFYSSTELDFTRQFYSSTELRFTRPSYSSTELGFSRLSHARNELSFTRQSQFSTEFDLTRPFYFSIELSFTRPSLSSIELDFTRQSYSSTELDFARQSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U8R8</accession>
    <name>A0A433U8R8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_002078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000038">
        <property type="protein sequence ID" value="RUS90199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U8R8"/>
    <dbReference type="OrthoDB" id="6139688at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS90199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="18458" checksum="CAFD8A32F5DC0126" modified="2019-05-08" version="1">MAFVATQFEDDGLPHLGAIDQLDQLWKRGVASAGNPSEASAQTCVNEESQSSGSSMAEQNAANNGGVPPQAVDLEATPDLELKIRIVYADSRVKNMEGSLNPTRTVQQLKARLATQLNMQPHLMDMHWSKQLTDGKLTEPRQLDNNRNLMHYEVETDDTIILTQLAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UA81</accession>
    <name>A0A433UA81_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_001524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000026">
        <property type="protein sequence ID" value="RUS90720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UA81"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS90720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="205" mass="24245" checksum="723DF65202F57E07" modified="2019-05-08" version="1">MFRIGGDGGGNTGCSSTAVHDVEGGSQTESRKRGREIRWTKRQNYRQTWHIIDDDGGEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEKITILKTATIYAKSFGSNANFRGETEGFRMTCANEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEVEKEEVIKSRLDKAISISGYEKKVNDSMDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UAH5</accession>
    <name>A0A433UAH5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">mRNA cap guanine-N(7) methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">mRNA (guanine-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">mRNA cap methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EGW08_001411</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">EC2010</strain>
            <tissue evidence="15">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:67008"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.1.1.56"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.56" evidence="10"/>
    <dbReference type="EMBL" id="RQTK01000024">
        <property type="protein sequence ID" value="RUS90792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UAH5"/>
    <dbReference type="STRING" id="188477.A0A433UAH5"/>
    <dbReference type="OrthoDB" id="10248867at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004482">
        <property type="term" value="F:mRNA 5'-cap (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004971">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016899">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039753">
        <property type="entry name" value="RG7MT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189:SF2">
        <property type="entry name" value="MRNA CAP GUANINE-N7 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189">
        <property type="entry name" value="MRNA GUANINE-7- METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03291">
        <property type="entry name" value="mRNA_G-N7_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028762">
        <property type="entry name" value="ABD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51562">
        <property type="entry name" value="RNA_CAP0_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 10 12" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MRNA cap 0 methyltransferase" evidence="14">
        <location>
            <begin position="35"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="360"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="365"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="44"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>mRNA</name>
            <dbReference type="ChEBI" id="CHEBI:33699"/>
        </ligand>
        <ligandPart>
            <name>mRNA cap</name>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="12">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="12">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="12">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="12">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="12">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="12">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR028762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR028762-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR028762-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RUS90792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="389" mass="43734" checksum="7CB11F4BB0377AD3" modified="2019-05-08" version="1">MMAAVPGSGSGDHSQTVANHYNKLEESGLEQRSRSRIFYLRNFNNWIKSVLIARTLEKLRVKDSQRTISVLDLCSGKGGDLLKWKKGKIDNLVCADIAATSVEQSEIRYNDNRQREGNRLYKAEFIVADCTKERLKDKYKNPDQSFDLVSCQFSFHYCFESYSQALMMLRNASECLRVGGYFIGTTPNSNELIRRLRKSTDNSFGNEVYNISFSQKDKTNFPLFGAMYNFHLEGVVDCPEFLVYFPVLERLASLFGLKLVKKWSFSEFFKQNLTHKESLSLLSAMQALEPFPSVGGTEPMSANKDDYKCAHEFLSSLSESHTQDSRRPLKIGTLSQAEWDAATIYLVFVFEKVGDMSPSFAAAPDSQSHTSASLSANRSSAGDGNKPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UBK7</accession>
    <name>A0A433UBK7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_001015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000016">
        <property type="protein sequence ID" value="RUS91209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UBK7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS91209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="250" mass="27159" checksum="33DA7BF7551F2056" modified="2019-05-08" version="1">MHTFYDLQPGEINESLLLLEVLRHHGHRYRAVKTNLLTLSPSFSSSLLFPFFCSSSSPLLLLPLFFILFIPSSLTPFYSSSLIPFIPPLTSSCTSSLLLFTPSLLHPPDLPSLCISSCSFCMSSSASACSCSHFSVCASPAHTPSLPTYLHLLHPPFSPAPAPPLIPPLLIAPPPLLPAPPAHTTSNYLPFHLLLLFFLLFLSLLLVLIFPFTAPPAASFSICLVKLVEGYSVKCLLSQTCGGLLFEMFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UCK4</accession>
    <name>A0A433UCK4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EGW08_000777</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">EC2010</strain>
            <tissue evidence="17">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000011">
        <property type="protein sequence ID" value="RUS91453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UCK4"/>
    <dbReference type="STRING" id="188477.A0A433UCK4"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901029">
        <property type="term" value="P:negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="14"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="114"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="210"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RUS91453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="307" mass="34182" checksum="BC02EAAE978C05DE" modified="2019-05-08" version="1">MEKKGPGITLGFAENFFLSGTSAIVSKTLAAPLERVKLLLQNQDELIRFGRLSHPYKGITDCIHRTFVAEGIRSFWRSNMVNCARYFPSQALNFAFNDQIKSLVPRSPTETQMQKLMINVACGGLAGVLSSCFVYSLDFARTRLANDAKLPGGGRQYTGLIDVYRQTLKTDGFQGLHRGFFISAVALMVYRGLYFGFYDSLKPVLLGDPPGVMEAFLLGYVITVTANLIAYPLDTVRRRMMMTTGEQVHYKGSIDCAMQIIRREGSMSMMKGAGANILRNIAGAGVLVGFDKSKEFYISWRLRREVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UD66</accession>
    <name>A0A433UD66_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_000540</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000007">
        <property type="protein sequence ID" value="RUS91714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UD66"/>
    <dbReference type="STRING" id="188477.A0A433UD66"/>
    <dbReference type="OrthoDB" id="4034597at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16713">
        <property type="entry name" value="RING-HC_BIRC2_3_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1170.10:FF:000002">
        <property type="entry name" value="Baculoviral IAP repeat containing 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050784">
        <property type="entry name" value="IAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044:SF139">
        <property type="entry name" value="DEATH-ASSOCIATED INHIBITOR OF APOPTOSIS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044">
        <property type="entry name" value="INHIBITOR OF APOPTOSIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="459"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="108"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="144"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS91714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="505" mass="54008" checksum="C007297E54FD33ED" modified="2019-05-08" version="1" fragment="single">NAAGNIPWALLREEKWRLLTYVRYPLNTAKSALLLAESGFVYVGSGEQLDDTVACFSCRCLKRGWREDEDIAETHRALSSDCAMVADTQVHPYANADNVPFGRQQSAATYNGATTGDPEPGGVLNGGSVASTNTVSTAMPEPTPQSSSSSSSSSSSSSSSSSSSSSSSSPPPSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTTSSSSQSSSTTSADQTSTPASDVPVVPTNPTYLELGIITEKPKRFQYAVASERLASFGEWPSDHHIKKEDLADAGFYYAGYSDCARCYYCGGGLRNWELEDDIWVEHARWFPRCAFIRQKLGQAFIDTVALLAQTNDKFFLSNPSFQLSINVVGSFLHADSRGTPLKKDAAVLTLKQHGFQEEDILPVAMFLKEKGQNLSAYTLFIALEKKGILPNLVQASNKTKKDDSKSEEILDTLKQQNSALRSQTVCKVCMDKEVAVVFLPCGHLVCCTDCAPALKLCPICRQQVKGIVRAFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UED6</accession>
    <name>A0A433UED6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LolA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_000162</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000002">
        <property type="protein sequence ID" value="RUS92138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UED6"/>
    <dbReference type="OrthoDB" id="6146361at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058831">
        <property type="entry name" value="LolA-like_dom_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36902">
        <property type="entry name" value="ENRICHED IN SURFACE-LABELED PROTEOME PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36902:SF1">
        <property type="entry name" value="ENRICHED IN SURFACE-LABELED PROTEOME PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25898">
        <property type="entry name" value="LolA_2nd_metazoa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019536820" description="LolA-like domain-containing protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="604"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="LolA-like" evidence="3">
        <location>
            <begin position="262"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS92138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="650" mass="73916" checksum="DC9B73F8C21C178B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z509</accession>
    <name>A0A3S0Z509_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_021393</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001322">
        <property type="protein sequence ID" value="RUS70846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z509"/>
    <dbReference type="STRING" id="188477.A0A3S0Z509"/>
    <dbReference type="OrthoDB" id="5547497at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="24"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS70846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="320" mass="36047" checksum="7129A7274CC26449" modified="2019-04-10" version="1">MTTMESNRKERLVAIGACANIGSSIIIVLLNKWIYTMYNFPNITLTCIHFIVTSFGLFICRHMNIFQPKSLPFMSMLPLAFSFCGFVVFTNLSLESNTVGTYQIIKTLTTPCIIFIQTYFYGRNFSFNVKLTLIPITLGVFLNSVYDIKFNFIGIMFATTGVMITSLYQVWVGEKQSELQVNSMQLLYYQAPLSAFLLLFVIPFFEPLDAFHGVFFNWPLEALAAVTLSACIAFSVNLSIFWIIGNTSAVTYNMIGHLKFSLTLIGGYLLFHDPIQPLQLLGILCTVAGVVAYTHIKRQEMRQKSLPTSIVSVNSNYSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z7Z7</accession>
    <name>A0A3S0Z7Z7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 192</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_019451</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM192 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001018">
        <property type="protein sequence ID" value="RUS72791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z7Z7"/>
    <dbReference type="STRING" id="188477.A0A3S0Z7Z7"/>
    <dbReference type="OrthoDB" id="6277625at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029399">
        <property type="entry name" value="TMEM192"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31592">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31592:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14802">
        <property type="entry name" value="TMEM192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS72791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="276" mass="31734" checksum="C624DCE01F112AC6" modified="2019-04-10" version="1">MVSLGNSRNSRGYFGFGEDHPTINSNDDELIVDHIDLISDHEMKHQPIGTTWAILFMKLLYIGLGVSAYIVPELCSLQVCGQDSISLTLYIHGGMWFVLFIVDRFLALKHRESRLNGYLDFYRRTQKIRSIPFHINSCANAIMVILTKLLDNLCGEPDKKCHVLGKIRYIQILVALECLLALIVLCVYFAKTVKFNRKKALPDVNQDELVTSFSSILSSIYPRNENYIDQVMEKQADMIRYLKQHTETLARRNLTLTEEIGRIRGLRRDNSIHGHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z977</accession>
    <name>A0A3S0Z977_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_019956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001087">
        <property type="protein sequence ID" value="RUS72284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z977"/>
    <dbReference type="OrthoDB" id="10353086at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="643"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="780"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS72284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1037" mass="114570" checksum="33849DB30AA2BC2F" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZAB5</accession>
    <name>A0A3S0ZAB5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SURP motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_019071</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000970">
        <property type="protein sequence ID" value="RUS73162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZAB5"/>
    <dbReference type="STRING" id="188477.A0A3S0ZAB5"/>
    <dbReference type="OrthoDB" id="447637at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.790:FF:000002">
        <property type="entry name" value="Splicing factor 3A subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.790:FF:000001">
        <property type="entry name" value="Splicing factor 3a, subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045146">
        <property type="entry name" value="SF3A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022030">
        <property type="entry name" value="SF3A1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316">
        <property type="entry name" value="SPLICEOSOME ASSOCIATED PROTEIN 114/SWAP SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316:SF1">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12230">
        <property type="entry name" value="PRP21_like_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="SURP motif" evidence="8">
        <location>
            <begin position="41"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="SURP motif" evidence="8">
        <location>
            <begin position="147"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS73162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="274" mass="31880" checksum="FC2B4F3BA81FFE1C" modified="2019-04-10" version="1" fragment="single">MPSIDMQQVPIEDGTQQTNEEAPAAKSSVGIIYPPPEVRNIVDKTASFVARNGPEFENRIRQNEVNNPKFNFLQPTDAYHGYYQHKVSEFKEGRGQEPQAPKQSQYLGVLRPTEAPKIVETFVPKDPPPEYEFMCDPPSISAYDLDVVKLTAQFVARNGRQFLTTVMQKEQRNFLFDFLRPQHSLFNYFTKLVEQYTKILIPPKNLIDKLTKEVTQPKEILDQVKYRVEWAKHQDRQKKKEEEALEKERVSYAQIDWHDFVVVETVDFQPTETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZAK8</accession>
    <name>A0A3S0ZAK8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial 2-oxoglutarate/malate carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">EGW08_017713</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">EC2010</strain>
            <tissue evidence="19">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(S)-malate(in) + 2-oxoglutarate(out) = (S)-malate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71587"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>maleate(in) + 2-oxoglutarate(out) = maleate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71599"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30780"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>malonate(in) + 2-oxoglutarate(out) = malonate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71591"/>
            <dbReference type="ChEBI" id="CHEBI:15792"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>oxaloacetate(in) + 2-oxoglutarate(out) = oxaloacetate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71603"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>succinate(in) + 2-oxoglutarate(out) = succinate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71595"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000823">
        <property type="protein sequence ID" value="RUS74525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZAK8"/>
    <dbReference type="STRING" id="188477.A0A3S0ZAK8"/>
    <dbReference type="OrthoDB" id="448427at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000013">
        <property type="entry name" value="Mitochondrial 2-oxoglutarate/malate carrier protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 16 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 17" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="16">
        <location>
            <begin position="15"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="16">
        <location>
            <begin position="108"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="16">
        <location>
            <begin position="208"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RUS74525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="312" mass="33794" checksum="EB83CA07B96720F4" modified="2019-04-10" version="1">MSNTNRPPKQMSKSIKFVFGGAAGMGATVFVQPLDLLKNRMQLSGMGGGQKQYKTSFHAFSAIFKNEGLSGIYSGLSAGLLRQATYTTTRLGIYSSLFDVFSKEGQPPNFLTKALIGVTAGGCGAFVGTPAEIALIRMTADGRLPVAEQRGYKNVFNAIGRIISEEGIFTLWRGCIPTVGRAMVVNAAQLASYSQAKQILISSSYFKEGLFLHFVASMISGLITTAASMPVDIAKTRIQNMKMIDGKPEFKGAFDVLGKVVRQEGFFSLWKGFTPYYARLGPHTVLTFIFLEQMNKMYKLYVLGDTSGGGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZDH9</accession>
    <name>A0A3S0ZDH9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sidoreflexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_015808</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sideroflexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000662">
        <property type="protein sequence ID" value="RUS76439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZDH9"/>
    <dbReference type="STRING" id="188477.A0A3S0ZDH9"/>
    <dbReference type="OrthoDB" id="6608471at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:monoatomic ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990542">
        <property type="term" value="P:mitochondrial transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004686">
        <property type="entry name" value="Mtc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00798">
        <property type="entry name" value="mtc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153">
        <property type="entry name" value="SIDEROFLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153:SF6">
        <property type="entry name" value="SIDEROFLEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03820">
        <property type="entry name" value="SFXNs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS76439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="323" mass="36240" checksum="2654B09176FE2AD4" modified="2019-04-10" version="1">MADVYPPFQLNKPRFDQGSFNGRLRHFMEVIDPRTLLTTSKQLEDAIRLLDKYKQGNVPDGTTDKQLWESQKIKQAIIHPDTGEKIFMPFRMSGFVPFGSFVVVGMLLPNSSMRQVIFWQWLNQSHNACVNFANRNASKPTPLKRFIFGYVGAVTTAVSIAVGLNLLIRRANSFSLTTKLLIQRLVPFPATATASTCNVLLMRNSELSEGVQVLDNRGNVVGTSQVAAKKALKETAVTRMFLPAPILLIPPMVMSLLEKRRFLIRNPRLHLPINSVVCTMAFWLALPVAIALFPQISEIKREHLEPAIQSATSESVLYYNKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZEB6</accession>
    <name>A0A3S0ZEB6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Rad4 beta-hairpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_015270</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000620">
        <property type="protein sequence ID" value="RUS76983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZEB6"/>
    <dbReference type="STRING" id="188477.A0A3S0ZEB6"/>
    <dbReference type="OrthoDB" id="300780at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071942">
        <property type="term" value="C:XPC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.20.110:FF:000001">
        <property type="entry name" value="DNA repair protein complementing XP-C cells"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2460:FF:000001">
        <property type="entry name" value="DNA repair protein Rad4 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.110">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.290">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2460">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018327">
        <property type="entry name" value="BHD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018026">
        <property type="entry name" value="DNA_repair_Rad4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018325">
        <property type="entry name" value="Rad4/PNGase_transGLS-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018326">
        <property type="entry name" value="Rad4_beta-hairpin_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018328">
        <property type="entry name" value="Rad4_beta-hairpin_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042488">
        <property type="entry name" value="Rad4_BHD3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00605">
        <property type="entry name" value="rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10403">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10404">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10405">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03835">
        <property type="entry name" value="Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01030">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01031">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01032">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="9">
        <location>
            <begin position="260"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="10">
        <location>
            <begin position="314"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="11">
        <location>
            <begin position="376"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="519"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="579"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="853"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="539"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="592"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="638"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="657"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="695"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="748"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="763"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="878"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="891"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="907"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="925"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS76983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="952" mass="107564" checksum="1A6CAFFD27C8B0BC" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZEK9</accession>
    <name>A0A3S0ZEK9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mammalian ependymin-related protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_019028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000965">
        <property type="protein sequence ID" value="RUS73206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZEK9"/>
    <dbReference type="OrthoDB" id="6084362at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001299">
        <property type="entry name" value="Ependymin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10697">
        <property type="entry name" value="MAMMALIAN EPENDYMIN-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10697:SF1">
        <property type="entry name" value="MAMMALIAN EPENDYMIN-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00811">
        <property type="entry name" value="Ependymin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018638478" description="Mammalian ependymin-related protein 1" evidence="1">
        <location>
            <begin position="16"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS73206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="22018" checksum="276C0175A6D9FD11" modified="2019-04-10" version="1">MLALLCLALVAGTMAQVPVTCPGPKQFEGRFRRYERERAGRGLVKGFIGYDETQRRIRVIEEQREQKEDSAYEYLIIYEQNLEYRVDLHTRKCNITQPREPFRPIGVPPEAKFMFEGVIGAAGVPGQTVTVAGFGGQFEGNEYEVSVTYPNCFPVTRGFKGKDGNLDLTTFYDLTNGISDPELFFPPKECIVGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZFT6</accession>
    <name>A0A3S0ZFT6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_018354</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000890">
        <property type="protein sequence ID" value="RUS73884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZFT6"/>
    <dbReference type="STRING" id="188477.A0A3S0ZFT6"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS73884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="552" mass="60809" checksum="443856C804E70CD9" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZGA1</accession>
    <name>A0A3S0ZGA1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_014032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000525">
        <property type="protein sequence ID" value="RUS78218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZGA1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS78218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="132" mass="14820" checksum="C9E899CC4F17DA5F" modified="2019-04-10" version="1" fragment="single">CLLLQSSKIQLTIILNAYFYNTSVCFSTAMILNVYCYNTSVCFLTAMILNAYCYNTRVCSSTAIIFNAQCYNTNCLLLDSSIIQVTMILNVYCYNTSVCFSTAMILNVYCYNTSDCFSTAMILNAYGYNTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZHR2</accession>
    <name>A0A3S0ZHR2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_013078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000467">
        <property type="protein sequence ID" value="RUS79170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZHR2"/>
    <dbReference type="OrthoDB" id="10608167at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS79170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="132" mass="14364" checksum="5262A531D08F69C2" modified="2019-04-10" version="1" fragment="single">TYSSVTFPSLTYSSVTFPSLTYSSVTFPSLTYSSVTFPSLTYSSVTFPSLTYSSVTFPSLTYSSVTFPSLTYSSVTFPSLTYSSVTFPSLTYSSVTFPSLTYSSVTFPSLTYSSVTFPSLTYSSVTFPSLTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZIX2</accession>
    <name>A0A3S0ZIX2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_012232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000416">
        <property type="protein sequence ID" value="RUS79998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZIX2"/>
    <dbReference type="STRING" id="188477.A0A3S0ZIX2"/>
    <dbReference type="OrthoDB" id="10066064at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480:SF1">
        <property type="entry name" value="TYR RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS79998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="599" mass="68479" checksum="E21B95C5C1172C1C" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZK08</accession>
    <name>A0A3S0ZK08_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_012746</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000448">
        <property type="protein sequence ID" value="RUS79478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZK08"/>
    <dbReference type="STRING" id="188477.A0A3S0ZK08"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005005">
        <property type="term" value="F:transmembrane-ephrin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000001">
        <property type="entry name" value="Ephrin type-A receptor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000986">
        <property type="entry name" value="Protein tyrosine kinase 2aa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050449">
        <property type="entry name" value="Ephrin_rcpt_TKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46877">
        <property type="entry name" value="EPH RECEPTOR A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46877:SF14">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="7">
        <location>
            <begin position="164"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS79478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="27581" checksum="BE8DEB72BD17FF2B" modified="2019-04-10" version="1" fragment="single">DLAARNILVNEGLVCKVADFGLSREIETDNTDGAYTTTGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVMWEIVSYGERPYYNWSNQDVIKAVEKGYRLPPPMDCPEAIHQLMLDCWQKERSHRPKLTQIVKTLDKLIRAPELLRKQAKPRPHNFIDPSTPDMTSLSSVEDWLVSIKMEKYLNLFLASGLTTMEQVRHLTVRDLLNMGVSLVGHQKKMMNSIQTFRAQTGDALHQHVPEAALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZLU8</accession>
    <name>A0A3S0ZLU8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Apolipoprotein D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_010213</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the calycin superfamily. Lipocalin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000308">
        <property type="protein sequence ID" value="RUS82022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZLU8"/>
    <dbReference type="OrthoDB" id="565904at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042246">
        <property type="term" value="P:tissue regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.20:FF:000003">
        <property type="entry name" value="Apolipoprotein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002969">
        <property type="entry name" value="ApolipopD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022271">
        <property type="entry name" value="Lipocalin_ApoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612">
        <property type="entry name" value="APOLIPOPROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612:SF34">
        <property type="entry name" value="APOLIPOPROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08212">
        <property type="entry name" value="Lipocalin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036893">
        <property type="entry name" value="Lipocalin_ApoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01219">
        <property type="entry name" value="APOLIPOPROTD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10" id="KW-0873">Pyrrolidone carboxylic acid</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018383799" description="Apolipoprotein D" evidence="11">
        <location>
            <begin position="23"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="12">
        <location>
            <begin position="41"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR036893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS82022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="202" mass="21670" checksum="55BE8859D18EF642" modified="2019-04-10" version="1">MDCKALLLVIFILAISTGISHCGIVLGLGKCPTVTAQSTLDKAQYLGVWYEYQRFPAIFEAGLDCTTATYGEDGDDISVTNAGTVRINLFGTKVVLNKNSVDGTATIPDSSKPAELQVSFGGFDMGNNSPNYFIQATDYTNYAVVFSCSEFLFVNIQFAWILTRDPGVAPTNLATLESNLSDAGVDVSKFMVIDQSGCPGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZNV7</accession>
    <name>A0A3S0ZNV7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_012948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000460">
        <property type="protein sequence ID" value="RUS79293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZNV7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS79293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="99" mass="11760" checksum="4E3D61D9CC69F1C2" modified="2019-04-10" version="1">MKVWCGKENRLHSLCLNPQRDNALAFENYYKRHRCVSSISSIILSYNLQWNPPLVVLIFLFILCFVFYYLTFCIECVQSLSHICDCYFFISLVALMREC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZR55</accession>
    <name>A0A3S0ZR55_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_018865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000944">
        <property type="protein sequence ID" value="RUS73363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZR55"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS73363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="253" mass="28205" checksum="51C65B2D4839DB41" modified="2019-04-10" version="1">MLFMMNKELEDKRQEYFYKNKQSLKEKHDHLRSSPVPSGQEYSLISQEVGENRYSSSESFDVNERRAEHTSMGINDGLEATPGNSTKHFPEKKCTVLPVMSDLPSLENLSLQSEKSNSPLSYVKKTPWHEEFPTSTCGKTALLGSSYPSQSLLPHSEPATVTGGWSSSQTSPRDLSSSSGPKYDRAESTNCQPVVQHHIHNHVHHHTTEITSAKYVTVGGNINAVDHTEDSDKEGDSSDEKKDSSDNEEYIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZRF2</accession>
    <name>A0A3S0ZRF2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AP3A hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_011220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000360">
        <property type="protein sequence ID" value="RUS81015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZRF2"/>
    <dbReference type="STRING" id="188477.A0A3S0ZRF2"/>
    <dbReference type="OrthoDB" id="415411at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16018">
        <property type="entry name" value="Enpp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF120">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="451"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS81015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="58003" checksum="19FDDE1D5961DC85" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZRM3</accession>
    <name>A0A3S0ZRM3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_007060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein light chain Tctex-type family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000179">
        <property type="protein sequence ID" value="RUS85156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZRM3"/>
    <dbReference type="STRING" id="188477.A0A3S0ZRM3"/>
    <dbReference type="OrthoDB" id="10260741at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21451">
        <property type="entry name" value="DLC-like_TCTEX1D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1140.40:FF:000003">
        <property type="entry name" value="tctex1 domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF7">
        <property type="entry name" value="DYNEIN LIGHT CHAIN TCTEX-TYPE PROTEIN 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS85156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="108" mass="12427" checksum="09626F27A7C9A5C2" modified="2019-04-10" version="1" fragment="single">PKVKFETAQVRNCIKSVLESRLERFPYNPKFCANMSRVLSDEIKKGVKGMNFDRYKIVCSVIIGEQKGQGIHVTSRCAWDEKLDNFASYSFQNEKIFCTATVFGVYNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZS36</accession>
    <name>A0A3S0ZS36_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Peptidase M13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_010857</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000340">
        <property type="protein sequence ID" value="RUS81385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZS36"/>
    <dbReference type="OrthoDB" id="6061414at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF240">
        <property type="entry name" value="GH14155P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="10">
        <location>
            <begin position="368"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="9">
        <location>
            <begin position="896"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="62"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="249"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="258"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS81385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1040" mass="114199" checksum="33BA648871F670F8" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZWD3</accession>
    <name>A0A3S0ZWD3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_004608</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000105">
        <property type="protein sequence ID" value="RUS87623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="188477.A0A3S0ZWD3"/>
    <dbReference type="OrthoDB" id="5946465at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:BRCA1-A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS87623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="120" mass="13079" checksum="1C9BC124A81A6CAF" modified="2019-04-10" version="1">MEDKGQALVWKIKNGELGDVKMFVEKEGIDVNIEVQGRLPLHYAADYGQTDVMEYLLSKGAKVNAEDKYGITPLLSAIFEGHTSSVKLLMEKGADKSGKAPDGASYIDCAESEDIKALLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZXI2</accession>
    <name>A0A3S0ZXI2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_014581</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000562">
        <property type="protein sequence ID" value="RUS77658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZXI2"/>
    <dbReference type="STRING" id="188477.A0A3S0ZXI2"/>
    <dbReference type="OrthoDB" id="6262491at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45532:SF3">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45532">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="312"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="353"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="539"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="871"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="972"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="539"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="883"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="986"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1030"/>
            <end position="1045"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS77658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1062" mass="118481" checksum="1F8245DD667F67F0" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZXP5</accession>
    <name>A0A3S0ZXP5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_003652</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
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                <person name="Feng M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Shigenobu S."/>
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                <person name="Nishiyama T."/>
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                <person name="Li S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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        <source>
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        </source>
    </evidence>
    <sequence length="1394" mass="154545" checksum="19B9EA1BCE6BC900" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A5E4</accession>
    <name>A0A3S1A5E4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_009093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000256">
        <property type="protein sequence ID" value="RUS83146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A5E4"/>
    <dbReference type="OrthoDB" id="6148643at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031110">
        <property type="term" value="P:regulation of microtubule polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000956">
        <property type="entry name" value="Stathmin_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00836">
        <property type="entry name" value="Stathmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00345">
        <property type="entry name" value="STATHMIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51663">
        <property type="entry name" value="STATHMIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS83146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="161" mass="19278" checksum="83D1629D89AC1203" modified="2019-04-10" version="1">MSFEIVTTESFDTPGLPRPPPRQLEKLEKRRKKKRSLLTEDEIKEKLERAELRRKKREEERLNKLKEIQRTDALASLENFEVYKKERQEQIQNHKMDIVADNRDKRMRDIKAKLQERERRAAQVRRRRQEALEHGLATAGVINNEEEYPNSARDNPAFSQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A9K6</accession>
    <name>A0A3S1A9K6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Malonyl-CoA decarboxylase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_006057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000148">
        <property type="protein sequence ID" value="RUS86163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A9K6"/>
    <dbReference type="STRING" id="188477.A0A3S1A9K6"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050080">
        <property type="term" value="F:malonyl-CoA decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001294">
        <property type="term" value="P:malonyl-CoA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.150">
        <property type="entry name" value="Malonyl-CoA decarboxylase, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.90">
        <property type="entry name" value="Malonyl-CoA decarboxylase, oligemerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038917">
        <property type="entry name" value="Malonyl_CoA_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007956">
        <property type="entry name" value="Malonyl_CoA_deC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042303">
        <property type="entry name" value="Malonyl_CoA_deC_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035372">
        <property type="entry name" value="MCD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038351">
        <property type="entry name" value="MCD_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28641">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28641:SF1">
        <property type="entry name" value="MALONYL-COA DECARBOXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05292">
        <property type="entry name" value="MCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17408">
        <property type="entry name" value="MCD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malonyl-CoA decarboxylase N-terminal" evidence="2">
        <location>
            <begin position="90"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Malonyl-CoA decarboxylase C-terminal" evidence="1">
        <location>
            <begin position="188"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Malonyl-CoA decarboxylase C-terminal" evidence="1">
        <location>
            <begin position="323"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS86163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="551" mass="62606" checksum="0A47B73BF4ECE79C" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AB27</accession>
    <name>A0A3S1AB27_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">IRS-type PTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_005037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000117">
        <property type="protein sequence ID" value="RUS87197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S1AB27"/>
    <dbReference type="OrthoDB" id="10071636at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050996">
        <property type="entry name" value="Docking_Protein_DOK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21258">
        <property type="entry name" value="DOCKING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21258:SF56">
        <property type="entry name" value="IRS-TYPE PTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02174">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01244">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00310">
        <property type="entry name" value="PTBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51064">
        <property type="entry name" value="IRS_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IRS-type PTB" evidence="2">
        <location>
            <begin position="198"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="745"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="871"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1045"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1217"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="478"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="602"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="675"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="887"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="899"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="945"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1142"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1159"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1176"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1217"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1282"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1311"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1382"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1420"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1433"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1467"/>
            <end position="1479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS87197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1490" mass="161740" checksum="73DDC8F4AA594DFD" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AH33</accession>
    <name>A0A3S1AH33_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_000310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000004">
        <property type="protein sequence ID" value="RUS91908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AH33"/>
    <dbReference type="OrthoDB" id="6142482at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="7"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS91908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="270" mass="30992" checksum="DD44FEC35EAC8749" modified="2019-04-10" version="1">MARLAFCHSQTVVNLLWQFATHWSLTAYYRGIPYLSVVDCGPGRFAIWRELKNETSFAICKELEQIFCERGPVAEVLMDNGAAFRSAELNDLLRRWSTSPFFRAAHRASGNGIVERNHRTIKAISERGRVSPMKAVFWYNMSPRSGQKEATIPQRSVHSYSWRHPDVEPHIEPQESRSSFSIGDEVWVKPAAVKCTTQWEKGNVSKINSKNNVEVNGVPRRVLDLRQVVVNPEADDLESHPLPDDEDSAGERRYPQRLRRVPTWVEDYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1ARD0</accession>
    <name>A0A3S1ARD0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_022271</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001525">
        <property type="protein sequence ID" value="RUS69963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1ARD0"/>
    <dbReference type="OrthoDB" id="411632at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011735">
        <property type="entry name" value="WlaTC/HtrL_glycosyltransf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09612">
        <property type="entry name" value="HtrL_YibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS69963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="338" mass="38493" checksum="F4F1A1F1CF984AAD" modified="2019-04-10" version="1">MMGTFININYLPEDSFVSVQDVLTCPDPSDDPDFYSGREDADDVTIVTMFLNIGSIYSTKLYFFKVMSSQVEDYHSWLHSWGKIKNRVVAFFDDETFIRSFKLYRSHLPKELTTVLKISKDDLPAFRSKERVRQILEDPQFIPSYDPDYTCTMDAKYDALDMALTGGHVKTKYVAWMDLGLFRKVKPTDPTFSLAPPPGLNTSRVGVSQVTARKAVESLSETEIYRKNIVWVAGGFLIATRPIMSQFIINYREVSAHLKLRGLADTDQQVLASMYSPTEQGKYDIQLTTYSCPRGAFGLFGYKYLYFCLPYICKASSECKARAAAHYVSPDELSHVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1ATZ3</accession>
    <name>A0A3S1ATZ3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein SMG9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_020199</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMG9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001125">
        <property type="protein sequence ID" value="RUS72035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1ATZ3"/>
    <dbReference type="STRING" id="188477.A0A3S1ATZ3"/>
    <dbReference type="OrthoDB" id="79514at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039177">
        <property type="entry name" value="SMG9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14270">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR SMG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14270:SF0">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR SMG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="105"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS72035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="510" mass="56825" checksum="15C4A95233624234" modified="2019-04-10" version="1">MADEKLRRRRRKDYGSGSHYSPGMRHREEISPSPSPRKPPITILGLAKPSRVASPTTQPDGDNSAAGGDTRQTDTAQSQQDPPTAAVQDKPSVVLLSDNRARYGQAKAAGDGEYSDSSAQNTQSGSYASEEGSPVVSSIKRSAPGTIISNVIDQSAQMQSKLAPPFEKQGKIKLVDDHFQWCDSGLDLMLEQSDFLVVGAVGLQGCGKSTLLSLLAGNTPQDAYRNYLFYPQTKETKEDCLFQTSGIDMFVTSDRIILLDTEPLLSASMMDCLLRYERKFPPEYTSLQNFIEMQSMQLLTFLLSVCNIVLVADDWFVDMSLLRLLQDAEMLKPSTQPSSSSAENMAKDYDLDLYPTVIFVHNKASHDDFTPRSYFDMQKILNEVFSSSKLKFRSGLNMSNNWGSEPIIPRKPGSENDPASNVNLLLLPTMEFYKAEPEPLETSLPEYRGYPSFKSILAYCRSQILSAPRSPVTHSALSEKNWYHFSARMWESVKKSPLLMEYNRLLSTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AZB3</accession>
    <name>A0A3S1AZB3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EGW08_016215</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">EC2010</strain>
            <tissue evidence="15">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000693">
        <property type="protein sequence ID" value="RUS76010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AZB3"/>
    <dbReference type="STRING" id="188477.A0A3S1AZB3"/>
    <dbReference type="OrthoDB" id="3824970at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14421">
        <property type="entry name" value="CUE_AMFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16455">
        <property type="entry name" value="RING-H2_AMFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000149">
        <property type="entry name" value="E3 ubiquitin-protein ligase AMFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057992">
        <property type="entry name" value="TPR_SYVN1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067:SF5">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE AMFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25563">
        <property type="entry name" value="TPR_SYVN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="269"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="14">
        <location>
            <begin position="382"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="429"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="529"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="434"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="451"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="477"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="538"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="601"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RUS76010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="611" mass="69026" checksum="E4482C392215C5C0" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AZY5</accession>
    <name>A0A3S1AZY5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_023756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01002606">
        <property type="protein sequence ID" value="RUS68482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AZY5"/>
    <dbReference type="STRING" id="188477.A0A3S1AZY5"/>
    <dbReference type="OrthoDB" id="343114at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="144"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS68482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="249" mass="29094" checksum="4115D454122ABEA5" modified="2019-04-10" version="1" fragment="single">MHPRLFVTDTPETILTDFSNRPDISIYCDRCAVYIDIRNLPYHKSYHEALLTLNYRNMQKPHDTRALMQRRNIIIKKMKSEITSENPLRPNVIKKIDDAFEILKGDLEDSYEEIKQVNEKVDWNVRAVSLNCSPSCAYAVGMCSSENNRWKSCMEDCKVYQDYFGEDRNKCYLAVFDGHHGEFSAERSANEMHHLLLHEMAKFDSKTKSTTARNFAESVTARKDYEQLRPETRDSIRVNLHQDSAEIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B0R8</accession>
    <name>A0A3S1B0R8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">UMP-CMP kinase</fullName>
            <ecNumber evidence="11">2.7.4.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Deoxycytidylate kinase</fullName>
            <shortName evidence="11">CK</shortName>
            <shortName evidence="11">dCMP kinase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Uridine monophosphate/cytidine monophosphate kinase</fullName>
            <shortName evidence="11">UMP/CMP kinase</shortName>
            <shortName evidence="11">UMP/CMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_018878</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>CMP + ATP = CDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>UMP + ATP = UDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>dCMP + ATP = dCDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.14" evidence="11"/>
    <dbReference type="EMBL" id="RQTK01000945">
        <property type="protein sequence ID" value="RUS73359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B0R8"/>
    <dbReference type="STRING" id="188477.A0A3S1B0R8"/>
    <dbReference type="OrthoDB" id="442176at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036430">
        <property type="term" value="F:CMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036431">
        <property type="term" value="F:dCMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000315">
        <property type="entry name" value="Adenylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03172">
        <property type="entry name" value="Adenylate_kinase_UMP_CMP_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006266">
        <property type="entry name" value="UMP_CMP_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01359">
        <property type="entry name" value="UMP_CMP_kin_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 11" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 12" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMPbind" evidence="11">
        <location>
            <begin position="93"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="11">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="73"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="121"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="148"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>CMP</name>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS73359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="252" mass="28107" checksum="00C26DB4D6E6B408" modified="2019-04-10" version="1">MLFILRTRYQSLISGKLQVSSYLKTTLSFLQHKTIIPVSGNIGSCVTKKVSVLSTMADSKNQYNVVFVLGGPGAGKGTQCEKIQETFGFQHLSAGELLRQERQAPNSQYGEEIETHLKNGSIVPVQITCSLLKREMDNSPKSNFLIDGFPRNKDNLDGWNSEMEGVAKVRAVLFFDCPDQVCVDRCLKRGVTSGRTDDNEESLKKRIETYRNSTMPIITHYRALDLVAQVDGNRSTEEVFADVEKVFKGLAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B1E1</accession>
    <name>A0A3S1B1E1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_014705</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="RQTK01000574">
        <property type="protein sequence ID" value="RUS77521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B1E1"/>
    <dbReference type="STRING" id="188477.A0A3S1B1E1"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14209">
        <property type="entry name" value="STKc_PKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044109">
        <property type="entry name" value="STKc_PKA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF153">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0114">cAMP</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="54"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="310"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS77521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="362" mass="41640" checksum="A5133910E903C4E7" modified="2019-04-10" version="1">MGNAATAKKGDPAENVKEFLARAKEEFQQKWDHPPAITHRAKIQESSSSTLDDFDRIKTLGTGSFGRVMLVQHKGESKTYFAMKILDKQKVVKLKQVEHTLNEKKILQSINFPFLVRLEFSFKDNSNLYMVLEFVTGGEMFSHLRRIGRFSEGHSRFYAAQIILSFEYLHYLDLVYRDLKPENLLIDPHGYCKVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRYGNLKNGVNDIKNHKWFASTDWIAIYQRKVEAPFVPKTKGAGDTGNFDDYEEEPLRISSTEKCAKEFADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BBM4</accession>
    <name>A0A3S1BBM4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pirin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_012563</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="1">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000435">
        <property type="protein sequence ID" value="RUS79679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BBM4"/>
    <dbReference type="STRING" id="188477.A0A3S1BBM4"/>
    <dbReference type="OrthoDB" id="198735at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008127">
        <property type="term" value="F:quercetin 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02247">
        <property type="entry name" value="cupin_pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02909">
        <property type="entry name" value="cupin_pirin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903:SF8">
        <property type="entry name" value="PIRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin C-terminal" evidence="2">
        <location>
            <begin position="156"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR006232-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS79679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="270" mass="30053" checksum="146B22F5E51B2345" modified="2019-04-10" version="1" fragment="single">ESMSRTVDQTFESKWQDEGIGARVRRSIGRPGLRNFDPFLLCDEFCVRAPAGFPDHPHRGFETNQLYFYQPACLSQWMTAGRGIVHCEMPGGKEDALGIQLWVNLKRADKLVTPAYQELVDKDIPRGEKSGVKVKVIAGEAFGIKSPVYTRTPTSYLDFTMGPGSKLDQPIAPSWNCFAYILSGEAAFGEPYAYLILSYPVLTCCLCIYPQSSSPCHFILVSGEPIEEPVVQHGPFVMTSQEEIAQAMRDYRGAKNGFENAATWNSDFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BCQ8</accession>
    <name>A0A3S1BCQ8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_014638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000568">
        <property type="protein sequence ID" value="RUS77599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BCQ8"/>
    <dbReference type="OrthoDB" id="6091627at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="533"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="572"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS77599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="610" mass="66052" checksum="5DF7572370B04346" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BFN4</accession>
    <name>A0A3S1BFN4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UPAR/Ly6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_009664</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000280">
        <property type="protein sequence ID" value="RUS82590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BFN4"/>
    <dbReference type="OrthoDB" id="10493807at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10036">
        <property type="entry name" value="CD59 GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10036:SF3">
        <property type="entry name" value="PROTEIN SLEEPLESS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018789437" description="UPAR/Ly6 domain-containing protein" evidence="3">
        <location>
            <begin position="29"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS82590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="15758" checksum="EDAFE55AA50D7EEF" modified="2019-04-10" version="1">MPNLRLTQHQKDLANIWMLALLVTSVQTLECYSCVTSHGPDCLSSSTVTCPAGQVCSNTVYRRGYSLGLLYTKGCEDELQCVRLANLNSAAYCDHAPSQCQYCCSGDLCNGAATPPSVSGNFKIRHWLTMTGCLLFGTFALSSMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BH95</accession>
    <name>A0A3S1BH95_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Spondin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">F-spondin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EGW08_008630</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">EC2010</strain>
            <tissue evidence="15">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000237">
        <property type="protein sequence ID" value="RUS83611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BH95"/>
    <dbReference type="STRING" id="188477.A0A3S1BH95"/>
    <dbReference type="OrthoDB" id="347314at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08544">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000020">
        <property type="entry name" value="Collagen, type VI, alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2130:FF:000002">
        <property type="entry name" value="Putative Spondin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000026">
        <property type="entry name" value="Spondin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2130">
        <property type="entry name" value="F-spondin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4060">
        <property type="entry name" value="Reeler domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002861">
        <property type="entry name" value="Reeler_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042307">
        <property type="entry name" value="Reeler_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051418">
        <property type="entry name" value="Spondin/Thrombospondin_T1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009465">
        <property type="entry name" value="Spondin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038678">
        <property type="entry name" value="Spondin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044004">
        <property type="entry name" value="TSP1_spondin_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038123">
        <property type="entry name" value="NF038123_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311">
        <property type="entry name" value="SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311:SF16">
        <property type="entry name" value="SPONDIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02014">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06468">
        <property type="entry name" value="Spond_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19028">
        <property type="entry name" value="TSP1_spondin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51019">
        <property type="entry name" value="REELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51020">
        <property type="entry name" value="SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Reelin" evidence="13">
        <location>
            <begin position="37"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Spondin" evidence="14">
        <location>
            <begin position="219"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="12">
        <location>
            <begin position="601"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RUS83611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="706" mass="80220" checksum="79AAF90862B7FDB0" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BHM4</accession>
    <name>A0A3S1BHM4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">EGW08_003727</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">EC2010</strain>
            <tissue evidence="25">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20 27">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 27">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="RQTK01000081">
        <property type="protein sequence ID" value="RUS88469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BHM4"/>
    <dbReference type="STRING" id="188477.A0A3S1BHM4"/>
    <dbReference type="OrthoDB" id="2914378at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030832">
        <property type="term" value="P:regulation of actin filament length"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01379">
        <property type="entry name" value="MYSc_Myo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052409">
        <property type="entry name" value="Myosin-III_kinase_activity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036083">
        <property type="entry name" value="MYSc_Myo3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46256">
        <property type="entry name" value="AGAP011099-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46256:SF3">
        <property type="entry name" value="MYOSIN MOTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 21" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="12 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="14 21" id="KW-0505">Motor protein</keyword>
    <keyword evidence="13 21" id="KW-0518">Myosin</keyword>
    <keyword evidence="10 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="18" id="KW-0844">Vision</keyword>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="24">
        <location>
            <begin position="199"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="741"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="21">
        <location>
            <begin position="822"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1121"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="22">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="745"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="769"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="1121"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="1133"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="1172"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="292"/>
            <end position="299"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="25">
        <location>
            <position position="1228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="RUS88469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1228" mass="140149" checksum="05737BA6DDC6D040" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BIA2</accession>
    <name>A0A3S1BIA2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_007948</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000210">
        <property type="protein sequence ID" value="RUS84304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BIA2"/>
    <dbReference type="OrthoDB" id="6103745at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018694259" description="EGF-like domain-containing protein" evidence="4">
        <location>
            <begin position="28"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="539"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="599"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="626"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="490"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="294"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS84304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="650" mass="72661" checksum="E40B5E141176D681" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BJS1</accession>
    <name>A0A3S1BJS1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_023343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001941">
        <property type="protein sequence ID" value="RUS68894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BJS1"/>
    <dbReference type="STRING" id="188477.A0A3S1BJS1"/>
    <dbReference type="OrthoDB" id="10051775at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4020.10">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038269">
        <property type="entry name" value="SCAN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888:SF1">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888">
        <property type="entry name" value="ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47353">
        <property type="entry name" value="Retrovirus capsid dimerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS68894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="255" mass="29832" checksum="2AD432801A5A7967" modified="2019-04-10" version="1">MVSTRWLTRWDRAEATTKSNAKLPKLPPFVDYKDDLDNWLLRFERFAETSQWQKESWPAYLSALLTGRALDCFCRLSTEDVKNYDAIKLALQKRYNLTEDGYRSMVRQCKPEEGENPGMFVVRLKTYLEMWIKLSATEQTYDSLRDLFVREQFIDSSPTALSVHLREKRLRSLDELSRETDAYLVARNRQMCKSKSSTHGNNGLFKSNGCEHKTAVCFLCNKTGHRAADCRTNIDVRYDVRCFKCRKVGQRQKHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BKR3</accession>
    <name>A0A3S1BKR3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">small monomeric GTPase</fullName>
            <ecNumber evidence="1">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_006159</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="1"/>
    <dbReference type="EMBL" id="RQTK01000151">
        <property type="protein sequence ID" value="RUS86066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BKR3"/>
    <dbReference type="STRING" id="188477.A0A3S1BKR3"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032486">
        <property type="term" value="P:Rap protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04175">
        <property type="entry name" value="Rap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000182">
        <property type="entry name" value="ras-related protein Rap-1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038851">
        <property type="entry name" value="Rap1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS86066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="184" mass="20732" checksum="CE0C12A23C40B4CC" modified="2019-04-10" version="1">MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDGQQCMLEILDTAGTEQFTAMRDLYMKNGQGFLLVYSITAQSTFNDLQDLREQILRVKDTDDVPMLLVGNKCDLEDERVVGKDQGSSLARTFQCAFLETSAKMKINVLEIFYDLVRQINKKNPGPGKQNKKKSKCALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BSF1</accession>
    <name>A0A3S1BSF1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acireductone dioxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Fe(2+)-requiring)</fullName>
            <shortName evidence="11">ARD'</shortName>
            <shortName evidence="11">Fe-ARD</shortName>
            <ecNumber evidence="11">1.13.11.54</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Ni(2+)-requiring)</fullName>
            <shortName evidence="11">ARD</shortName>
            <shortName evidence="11">Ni-ARD</shortName>
            <ecNumber evidence="11">1.13.11.53</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_002002</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:49016"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.53"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16723"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="11">Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the acireductone dioxygenase (ARD) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.54" evidence="11"/>
    <dbReference type="EC" id="1.13.11.53" evidence="11"/>
    <dbReference type="EMBL" id="RQTK01000037">
        <property type="protein sequence ID" value="RUS90221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BSF1"/>
    <dbReference type="STRING" id="188477.A0A3S1BSF1"/>
    <dbReference type="OrthoDB" id="1867259at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010308">
        <property type="term" value="F:acireductone dioxygenase (Ni2+-requiring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010309">
        <property type="term" value="F:acireductone dioxygenase [iron(II)-requiring] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02232">
        <property type="entry name" value="cupin_ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000099">
        <property type="entry name" value="1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03154">
        <property type="entry name" value="Salvage_MtnD_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004313">
        <property type="entry name" value="ARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027496">
        <property type="entry name" value="ARD_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418:SF0">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03079">
        <property type="entry name" value="ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="3 11" id="KW-0533">Nickel</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS90221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="184" mass="21948" checksum="2CD501675AC7472E" modified="2019-04-10" version="1">MVRAWYHDGADNEPRSHPHMMDPCQFLSLEELNKITGAEYFQFDADTIESNEEYQKLRRERGYKNEDCVELTRETLPNYDEKMEIFYKEHLHEDEEIRFIVDGTGYFDLRTAGSDQWIRIEVTKNDMLIVPAGTYHRFTLDTNEYIKSRRLFTELPKWTPINRPIGDEHPMRLQYLRDMSAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BSK9</accession>
    <name>A0A3S1BSK9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_001706</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000030">
        <property type="protein sequence ID" value="RUS90529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BSK9"/>
    <dbReference type="STRING" id="188477.A0A3S1BSK9"/>
    <dbReference type="OrthoDB" id="407010at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003834">
        <property type="term" value="F:beta-carotene 15,15'-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
        <property type="term" value="P:carotene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042574">
        <property type="term" value="P:retinal metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF24">
        <property type="entry name" value="CAROTENOID ISOMEROOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="521"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS90529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="531" mass="59551" checksum="E71DFEBF88A2BCE0" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BV55</accession>
    <name>A0A3S1BV55_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_002677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000052">
        <property type="protein sequence ID" value="RUS89559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BV55"/>
    <dbReference type="OrthoDB" id="10028859at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS89559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="26094" checksum="874233B56E6AAC80" modified="2019-04-10" version="1">MSTPNIIIIIIIIIIIIIIIIIIIIIIIITIVVTIITITTTTTTNTTTTTTTTITIITLMLFTNQYFIEYRHTLTYHNAPPPPFPCPAPRRCEPLQPPRGGAVNCEINGDKMLCTAYCLGDATFTGGDPVLSRTCYENIGNFGGEDFPDCVGEGSVRPPQVNVNSPTPVCSPPPPFPSPRTCSHGFLYIRACPALLKFDAINGLCDYHSRTCQSRHRRFWLAERRMDTYWDQFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BVF9</accession>
    <name>A0A3S1BVF9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Uridine diphosphate glucose pyrophosphatase NUDT14</fullName>
            <ecNumber evidence="9">3.6.1.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Nucleoside diphosphate-linked moiety X motif 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_002588</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>UDP-sugar + H2O = UMP + alpha-D-aldose 1-phosphate.</text>
            <dbReference type="EC" id="3.6.1.45"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.45" evidence="9"/>
    <dbReference type="EMBL" id="RQTK01000050">
        <property type="protein sequence ID" value="RUS89667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BVF9"/>
    <dbReference type="STRING" id="188477.A0A3S1BVF9"/>
    <dbReference type="OrthoDB" id="10249920at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008768">
        <property type="term" value="F:UDP-sugar diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18887">
        <property type="entry name" value="NUDIX_UGPPase_Nudt14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000035">
        <property type="entry name" value="Uridine diphosphate glucose pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004385">
        <property type="entry name" value="NDP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00052">
        <property type="entry name" value="nudix-type nucleoside diphosphatase, YffH/AdpP family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF15">
        <property type="entry name" value="URIDINE DIPHOSPHATE GLUCOSE PYROPHOSPHATASE NUDT14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00080475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS89667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="218" mass="24483" checksum="B9625420A7DFF29E" modified="2019-04-10" version="1">MEDISDVRLSPLTESQFLIPKCVKYTQNGKRRTWDGISEHDDVEILLFNISRNVFVFVKQFRPAIYLSRIEPGELEGNAMIQSEKFPGRLGVTIELCAGIVDKCVPHLEIARAEVLEECGYDVPANSFSKITSCRNGTDLSGSLVTLFYAEITDSMKVSAGGGLANEGEFIEVVELSIEEARNLIFDETINREPCLLVALQWFFHEVYPKKIQDVGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BZQ8</accession>
    <name>A0A3S1BZQ8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="10">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_013176</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="10"/>
    <dbReference type="EMBL" id="RQTK01000473">
        <property type="protein sequence ID" value="RUS79071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BZQ8"/>
    <dbReference type="STRING" id="188477.A0A3S1BZQ8"/>
    <dbReference type="OrthoDB" id="9215500at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04300">
        <property type="entry name" value="GT35_Glycogen_Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000005">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000153">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000197">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468:SF13">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="5 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS79071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="847" mass="97048" checksum="FD8723585C223C9D" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C5Y3</accession>
    <name>A0A3S1C5Y3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Beta-1,4-galactosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_008345</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyses the transfer of galactose onto proteins or lipids.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyltransferase 7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="RQTK01000226">
        <property type="protein sequence ID" value="RUS83864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C5Y3"/>
    <dbReference type="OrthoDB" id="10016069at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008378">
        <property type="term" value="F:galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00899">
        <property type="entry name" value="b4GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003859">
        <property type="entry name" value="Galactosyl_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027791">
        <property type="entry name" value="Galactosyl_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027995">
        <property type="entry name" value="Galactosyl_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300:SF57">
        <property type="entry name" value="BETA-1,4-N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02709">
        <property type="entry name" value="Glyco_transf_7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13733">
        <property type="entry name" value="Glyco_transf_7N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02050">
        <property type="entry name" value="B14GALTRFASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase N-terminal" evidence="13">
        <location>
            <begin position="137"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase C-terminal" evidence="12">
        <location>
            <begin position="255"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS83864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="411" mass="46851" checksum="6A482E317DBB3F37" modified="2019-04-10" version="1">MTRSSRATRRTWVLFFLIFVLSLMSTTFLFLPRLQPAASCTEASGLPRPNLRRSLHDPRELVHVELEAQPASLPVPDTIGQNDSPLAQDFFSLQSKPEDKVNSTQYSNLELFNKQKGLNGTLLTLVGRVDPPKEPMDIAQIVAMFSFMSGGHFVPKVAAPVEKVAILIPYRNRRKHLYTLLPVLIPLLMRQNAQFGIFVIELDAPTTFNKGALFNAGFLEIMKRDSYDCVILHDVDLLPLDDRNLYRCDKDHPTHFSANILHYSYFYNGLFGGVVGFTPRQFRAINGASNVYFGWGGEDDDLRDRALGKNFTIVRKPPEFAVYKMVHHTKRGYWKANPNRFRVFASRRARWDYDGLNSLRYTVTRAVSKRVVVWINIAINATQIVETVPADLRMSQEQDFVIDVKKGIINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C8E9</accession>
    <name>A0A3S1C8E9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ISXO2-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_006408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000158">
        <property type="protein sequence ID" value="RUS85856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C8E9"/>
    <dbReference type="STRING" id="188477.A0A3S1C8E9"/>
    <dbReference type="OrthoDB" id="6128111at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053164">
        <property type="entry name" value="IS1016-like_transposase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024445">
        <property type="entry name" value="Tnp_ISXO2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163">
        <property type="entry name" value="DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163:SF2">
        <property type="entry name" value="SI:DKEY-17M8.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12762">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01126">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ISXO2-like transposase" evidence="2">
        <location>
            <begin position="159"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS85856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="564" mass="63928" checksum="16C688E81888A9E6" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1CA13</accession>
    <name>A0A3S1CA13_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase III subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_005188</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the RNA polymerase III (Pol III) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the eukaryotic RPC7 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000121">
        <property type="protein sequence ID" value="RUS87035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1CA13"/>
    <dbReference type="STRING" id="188477.A0A3S1CA13"/>
    <dbReference type="OrthoDB" id="5377312at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024661">
        <property type="entry name" value="RNA_pol_III_Rpc31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15367">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15367:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11705">
        <property type="entry name" value="RNA_pol_3_Rpc31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000777">
        <property type="entry name" value="RNA_polIII_C31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="116"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS87035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="222" mass="25385" checksum="1C907F7C98FC158B" modified="2019-04-10" version="1">MAGRGRGRGRGLSINIEALGLGRGEIIPSVAQPPPLYPPLLFRPLPPARDTDLDYMVALRQELRFALHKSPYYVNAPHKAKDIERYSDKYILGANDGAQKWEPDWNMFPAELQEKKKRKFKTSGAKPNLKAARKVKAPDVSELLEKLEKVDETRENPEEETNENEETEEGVKKEKNGDDEDEEEEEYDEEDLEEETDYNLAYFDNGEGYGDDDEDDDEGPTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1CC62</accession>
    <name>A0A3S1CC62_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_003562</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000076">
        <property type="protein sequence ID" value="RUS88667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1CC62"/>
    <dbReference type="STRING" id="188477.A0A3S1CC62"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000176">
        <property type="entry name" value="pancreas/duodenum homeobox protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45664:SF12">
        <property type="entry name" value="PANCREAS_DUODENUM HOMEOBOX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45664">
        <property type="entry name" value="PROTEIN ZERKNUELLT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="16"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="73"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="73"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="147"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="222"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS88667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="276" mass="31897" checksum="63FB393DEFB87B0F" modified="2019-04-10" version="1">MFRLRACAQFSLEDETKRTRTAYTRGQLLELEKEFHFNKYISRPRRIELAAMLALTERHIKIWFQNRRMKWKKEEAKRRPLPRDGVGEKERDDHGDDAGMEEDKRDCETDGDDKDEEGEEEEKVGRGKDSNTKKVPLTKTTLKCEGQQLQLKPESPTSLSPSCSKLATDESWQCQDAKTPTNRQQFQHDHRQPKHAHHQSFLATNQKGKAQTQSEHSDNKRNSNGQSKLRQGVHYSNQVSPSMDNAESNQDLSSRKNFDLNGLSASIKLDLDFDKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1CDC9</accession>
    <name>A0A3S1CDC9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CCHC NOA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_002648</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000051">
        <property type="protein sequence ID" value="RUS89630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1CDC9"/>
    <dbReference type="STRING" id="188477.A0A3S1CDC9"/>
    <dbReference type="OrthoDB" id="6343844at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043122">
        <property type="term" value="P:regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.390">
        <property type="entry name" value="L1 transposable element, trimerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.990">
        <property type="entry name" value="Nemo cc2-lz domain - 1d5 darpin complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034735">
        <property type="entry name" value="NEMO_ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051301">
        <property type="entry name" value="Optineurin/NFkB_EssMod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31553">
        <property type="entry name" value="NF-KAPPA-B ESSENTIAL MODULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31553:SF1">
        <property type="entry name" value="NF-KAPPA-B ESSENTIAL MODULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51801">
        <property type="entry name" value="ZF_CCHC_NOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC NOA-type" evidence="10">
        <location>
            <begin position="718"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="688"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="30"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="168"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="302"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="434"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="591"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS89630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="750" mass="85496" checksum="9C84565FA7EB8A86" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H0G3</accession>
    <name>A0A3S1H0G3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_022465</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001581">
        <property type="protein sequence ID" value="RUS69769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H0G3"/>
    <dbReference type="STRING" id="188477.A0A3S1H0G3"/>
    <dbReference type="OrthoDB" id="289247at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042984">
        <property type="term" value="P:regulation of amyloid precursor protein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039862">
        <property type="entry name" value="NECAB1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12178">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12178:SF10">
        <property type="entry name" value="N-TERMINAL EF-HAND CALCIUM-BINDING PROTEIN 1-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="14"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="ABM" evidence="3">
        <location>
            <begin position="243"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS69769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="38974" checksum="FDFB10E99DD48154" modified="2019-04-10" version="1">MAEKAEITEVETEKGMTIFLDVFRRADKNDDGSISWDEFVSYFADGVMGKEELQTLFDEIDSHNTNNIDTNELCTYFSQHLGEFKEIFGLLEEMNKKMTNVLYGTAKVYQESNRTDKFVKRFLMREILNQMSALQRPIEAASDTLDTQAREERADIKPLELEDVIKKSPSGNIVPGRVVRRAKRQISGISTGSDAFEGLAEGGGMANTQIDRLAQLIDRLENKVNLDGFRDEEVVAGEDDLVLMVQREFSVKEASVDDFQSQLRAYVDLTQGFKGCLSASVRKLLDSHCFTIYEIWSTEERYLKNSESEATQILSQKTAELLEKPETVHTMKIPGSWWKREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H660</accession>
    <name>A0A3S1H660_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_019213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000984">
        <property type="protein sequence ID" value="RUS73027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H660"/>
    <dbReference type="STRING" id="188477.A0A3S1H660"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS73027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="285" mass="31076" checksum="AC5A71BC9741A2C9" modified="2019-04-10" version="1">MIITAAASTAREYSTGWLRGLSTGPTGTPRFTFHGTEQAGWLRGLSTRPTGIPRFTFHGTEQAGWLRGLSTGPTGTPRFTFHGTEQASWLRGLSTGPTGTPRFTFHGTEQAGWLRGLSTRPTGTPRFTFHGTEQAGWLRGLSTGPTGTPRFTFHGTEQASWLRGLSTGPTGTPRFTFHGTEQAGWLRESRHSFHHLTQNLSSFRVSGSENWESSFRVSGSENWESSFRVSGSENWESPFRVSGSENWAYAGKTGVTGEASELSLQAADRAVLHEPPETETTCTMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H991</accession>
    <name>A0A3S1H991_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_017519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000805">
        <property type="protein sequence ID" value="RUS74723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H991"/>
    <dbReference type="OrthoDB" id="10013007at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS74723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="151" mass="16338" checksum="5BB30D5705D609D7" modified="2019-04-10" version="1">MGVIMLSVILVDRKAGDKGRRDRYQRSDSARLVVQAMPISAATQQPKQTDLSKPQPHRFDSGAEGLGLGSGVDPSGFRPEDLPDGACYRPKKDLTNLPSTSHSGAGATKYSQDIKNSNTGLMEHIRAVECAPQRTLGFYPVVRTVQVAMPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HDS1</accession>
    <name>A0A3S1HDS1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">EGW08_014922</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">EC2010</strain>
            <tissue evidence="18">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000590">
        <property type="protein sequence ID" value="RUS77325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S1HDS1"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097729">
        <property type="term" value="C:9+2 motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000153">
        <property type="entry name" value="Dynein axonemal heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.130:FF:000010">
        <property type="entry name" value="Dynein axonemal heavy chain 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000005">
        <property type="entry name" value="Dynein axonemal heavy chain 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000007">
        <property type="entry name" value="Dynein axonemal heavy chain 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000006">
        <property type="entry name" value="Dynein axonemal heavy chain 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000884">
        <property type="entry name" value="Dynein axonemal heavy chain 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002141">
        <property type="entry name" value="Dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000013">
        <property type="entry name" value="Dynein heavy chain 10, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000008">
        <property type="entry name" value="Dynein heavy chain 10, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000008">
        <property type="entry name" value="Dynein heavy chain 10, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000002">
        <property type="entry name" value="dynein heavy chain 17, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000063">
        <property type="entry name" value="dynein heavy chain 6, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000049">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056759">
        <property type="entry name" value="DYH2-5-8_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF63">
        <property type="entry name" value="DYNEIN AXONEMAL HEAVY CHAIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25007">
        <property type="entry name" value="DYH2-5-8_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="4365"/>
            <end position="4398"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="1972"/>
            <end position="2108"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="2261"/>
            <end position="2393"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="2612"/>
            <end position="2763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="66"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="270"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="919"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1374"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3427"/>
            <end position="3489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RUS77325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="4623" mass="530545" checksum="F07996C66FD56442" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HIS8</accession>
    <name>A0A3S1HIS8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_011972</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000401">
        <property type="protein sequence ID" value="RUS80288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HIS8"/>
    <dbReference type="OrthoDB" id="6073595at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS80288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="557" mass="60179" checksum="0FE89A6D04546616" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HKB1</accession>
    <name>A0A3S1HKB1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_011028</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000349">
        <property type="protein sequence ID" value="RUS81234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HKB1"/>
    <dbReference type="STRING" id="188477.A0A3S1HKB1"/>
    <dbReference type="OrthoDB" id="10068077at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000067">
        <property type="entry name" value="sialin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF399">
        <property type="entry name" value="FI19708P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="41"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS81234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="276" mass="30212" checksum="8BB56883163A6F5F" modified="2019-04-10" version="1" fragment="single">MATLHNSNQSRPDGEVTPLLPPYSKEDESKKLQNGSQCIAARHVLAFLAFLGFFNVYCLRVNLSVALVAMVNSTDDNTSSATECPDPNINSTSESKTAEFNWDGKTQGMVLGSFFYGYITTQIPGGWLASRIGGKNLFGFGVLCTAVLTLITPVAVRYSVYLFIAVRILEGIGEGVTFPAMHAIWGNWAPVWERSKLAAFTYAGAQLGTVFSLPISGYLCDSDIAGGWPSVFYVFGALACVWFVVWMMFTYNTPADHPRISTSEREYIESSIGKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HNQ4</accession>
    <name>A0A3S1HNQ4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_009170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000259">
        <property type="protein sequence ID" value="RUS83084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HNQ4"/>
    <dbReference type="STRING" id="188477.A0A3S1HNQ4"/>
    <dbReference type="OrthoDB" id="6155297at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038800">
        <property type="entry name" value="CCDC17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33820">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33820:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="118"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="267"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS83084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="447" mass="52457" checksum="895448B9BF3F28FC" modified="2019-04-10" version="1" fragment="single">MPVDDTVADLRRLKAHRSRERELRDLEERKLLDELHDANRRLRGSPLGARARDKRKRFQLSKDETVREMQIQYERHREMNMAGGGRRDYRRKPELLPRYNPSNDPKVKQLAESHGRNMESFHTKNRDLERQREEIRRRLEGLGRRPIKEDDSMNALFQELKDQEARNQRMLEELRRILASQNIPMPQMPQQEPKTSRYVYPIYYGNSLVAEIIAVRQAYIQNGGNDPDILQQLAQMQAEAQAIDDSLRNRPAIKIKAGKAQPDNSNLFALELENERLQRQLLLLQEQNIQARHRRKDDREDELERDIRRMHQDHLRKMYELQREIERLRHDTVYLRMREQQPSKIIVQQPPPIQAPPPIITPAPVQTKYIEVDRLAPYDYSAGFVIFYDFVLNLDPRIGAVRLIVGLHNNQAKLGEPTILPLVYTEPGARQATAYNAPAVNAVIGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HPL6</accession>
    <name>A0A3S1HPL6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_008562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000235">
        <property type="protein sequence ID" value="RUS83656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HPL6"/>
    <dbReference type="STRING" id="188477.A0A3S1HPL6"/>
    <dbReference type="OrthoDB" id="6125136at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF1">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS83656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="27936" checksum="8DB80146A5D30788" modified="2019-04-10" version="1">MGDDNDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDNVGTHRKAIKHRTMSGKLSVVQTFNADKFALQLINLPTSIYSLRGRTGSSGRALVSRSGGPRIKSQDGQIYLTVLSHVTGWVGASVIRVRQDKVKDVVIQHDNARPHTSRQTQCALQQLELPTIPHPTYSPDLAPSDFFLFPLLKKHLKGNHYETDAEFEADVRSWCRSQTPEFFADGMRKLVQRWRLCIERDGDYVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SKT8</accession>
    <name>A0A433SKT8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_022500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001588">
        <property type="protein sequence ID" value="RUS69742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SKT8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS69742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="128" mass="15016" checksum="774AFDF51EB75F6A" modified="2019-05-08" version="1" fragment="single">TCAPTNSHIHNVRHVLCIHNHIHNVRHVLCTNSHIHNVRHVLCTNSHIHNVRHVLCTNSHIHNVRHVLCTNNHIHNVRHVLYTNSHIHNVKHVLYTNSHIHNVRHVLCIHSHIHNVRHVLCTNSHIHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SN98</accession>
    <name>A0A433SN98_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_021529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001350">
        <property type="protein sequence ID" value="RUS70709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SN98"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS70709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="245" mass="25384" checksum="7361DCFF9AAA7302" modified="2019-05-08" version="1">MDGSSLQGAVLSSVALGTGGTTPTLVAITSSMAGSSQVLLSDSASSQILNSSTIVNGLCPSSTEKSGSNSQRHHITKSHHYHQHPHHQQISHKAQQQQSITLGNMLQQAGGSTIAMPLAQGAAGTAQLCSSQAIFKQGGTTFNLTKTVGGKLTMQPVSLTFPINVSQAGLAALTSGKQQQQQQTLQQLQQQQQQQQQQHQHTLLVTSSTGAGGELVDGATVRVAGKTDMHLQAQLSSSSSGNLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SQZ1</accession>
    <name>A0A433SQZ1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like family domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_020574</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001177">
        <property type="protein sequence ID" value="RUS71668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SQZ1"/>
    <dbReference type="STRING" id="188477.A0A433SQZ1"/>
    <dbReference type="OrthoDB" id="300709at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00040296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS71668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="292" mass="33089" checksum="C713F9A55FCA8EA5" modified="2019-05-08" version="1" fragment="single">TGLQGGSVARALVQSGEFSVRGVTRDLSSQKAQRLRNDGVDLMNYDLNDRSGLQLILHGAYACFVNTATDFDDPNCLDTEIGQGCLIADYCKSERVQHVVLSSQLHSQNVCSIMARHLVAKAEIELYMRDLGLPLTSLIMPMYYENILDILRPSTTDGRNFDLEIPMGSFPLDMMCVDDVGPVVLNILRNRAHFLGKTETLCGDKITVREMAQVLSRYLKPRTFRDRQLTVHEFYQQRSCDLKGCIDWANMFQFFQRVDQRYNLSITKQMNPGLRSFEDWVRSNAQAISAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SR13</accession>
    <name>A0A433SR13_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_020544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001173">
        <property type="protein sequence ID" value="RUS71700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SR13"/>
    <dbReference type="OrthoDB" id="10638476at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS71700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="101" mass="11991" checksum="E0B620F4E01E8949" modified="2019-05-08" version="1" fragment="single">ITCCHERLITCCHERLITCCHERLITCCHERLITCCHERVITCCHERLISCCHERLITCCHERLITCCHERLITCCHQRLITCCHQRLISCCHERLISCCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SR17</accession>
    <name>A0A433SR17_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thyroid receptor-interacting protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_020527</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001171">
        <property type="protein sequence ID" value="RUS71717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SR17"/>
    <dbReference type="STRING" id="188477.A0A433SR17"/>
    <dbReference type="OrthoDB" id="425925at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921">
        <property type="entry name" value="MYOSIN HEAVY CHAIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921:SF2">
        <property type="entry name" value="THYROID RECEPTOR-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="209"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="259"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="370"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="44"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="262"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS71717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="45454" checksum="C201CA52CE9095AB" modified="2019-05-08" version="1" fragment="single">MSWIGGSLSSLTGQLSNLTKDILTEGTEEVSDPATELRLAHEKLHQLDGLLSTQRQENERLKRANRELEEKAEGSELQINTISREYRTVLEKKEKEVNTLKHQNQELLEQHARAAAFTAPSSSSSSSHGHSNDNHGWDSMNFDGDHGDWDFDDSIRLQRENNSLRSELHHWKSVAAQLGQNAGQNSQSQTAGADVFDLQHKVKSLEERLEKKSDELQQQAASLHEHHQQKIATLKARHQGEISKLQNEVTALEQRLVDARDGTSSSQHSGSTNLPESERPHNTSTDESLTARLEAALNDKKKAEDARVHLESMLEDLQREVQTLQTKNEALQAQEAALGNKVVELSAALQESKSTQQKLQEDLAEARTELQKQATESLQTVQKEQEKAMAGAEATLERLGEGDGAQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SUI5</accession>
    <name>A0A433SUI5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Neurotransmitter-gated ion-channel transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_019323</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001000">
        <property type="protein sequence ID" value="RUS72927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SUI5"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019565397" description="Neurotransmitter-gated ion-channel transmembrane domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS72927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="29688" checksum="F33E324F3A0B0555" modified="2019-05-08" version="1">MNLLFPTVALSFLNILVFVLPADSGEKITQFMAILVAISVFSVIGTVISLFVHHKMDRDKKEETQAMSVLSKWKEKMKRGIWKPVATKQVHPSKQTTKEGDKENHIHTESKDDFLQYTVPFETRKNDNSSSTIDGNVNPLAIFDNKHQIGPELREPSRVNNATLIQLQEEKDYEKVKNGSGVGGIASLWHRGRHKLNSDAMKGHKLNHDPLSGQGGPKCEAESGRGGAKNDILLLLKVHLDLIFFWMFLITWIGVTIGFSIAIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SWW3</accession>
    <name>A0A433SWW3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_018499</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000905">
        <property type="protein sequence ID" value="RUS73738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SWW3"/>
    <dbReference type="STRING" id="188477.A0A433SWW3"/>
    <dbReference type="OrthoDB" id="6262911at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042791">
        <property type="term" value="P:5S class rRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056467">
        <property type="entry name" value="eWH_GTF3C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044210">
        <property type="entry name" value="Tfc3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007309">
        <property type="entry name" value="TFIIIC_Bblock-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056428">
        <property type="entry name" value="WH_GTF3C1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04182">
        <property type="entry name" value="B-block_TFIIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24101">
        <property type="entry name" value="WHD_GTF3C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23704">
        <property type="entry name" value="WHD_GTF3C1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="General transcription factor 3C polypeptide 1 winged-helix" evidence="8">
        <location>
            <begin position="7"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="B-block binding subunit of TFIIIC" evidence="7">
        <location>
            <begin position="170"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="GTF3C1 extended winged-helix" evidence="9">
        <location>
            <begin position="542"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="463"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="465"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS73738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="872" mass="99553" checksum="53589471CA7C119A" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SX80</accession>
    <name>A0A433SX80_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_018316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000885">
        <property type="protein sequence ID" value="RUS73926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SX80"/>
    <dbReference type="STRING" id="188477.A0A433SX80"/>
    <dbReference type="OrthoDB" id="5584247at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.167.10:FF:000005">
        <property type="entry name" value="Putative A-kinase anchor protein 10 mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052246">
        <property type="entry name" value="Cell_Polariz_PKAAnc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155:SF1">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155">
        <property type="entry name" value="A-KINASE ANCHOR PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="1">
        <location>
            <begin position="12"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="1">
        <location>
            <begin position="278"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS73926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="388" mass="43438" checksum="29298DF9C24B2781" modified="2019-05-08" version="1" fragment="single">SPLRSSSRLSKTLLEVVRDQNALACFKAFMKSQRAEHFIQFWCDAESFHATALTRLHTHSFQCLSRKRRTESANSAVSETLGPKDDSANCEASAVVGGLTSETKEAFTENRLNEPSPASPNGEIVQCSAQCHSDVSSLAKADPPGLNQCRSASGDQWNLRNSNIPSVNDTVRAVRSGNLSQNSTTNVPSDPCVERDAVTIFSTYIAKDAPRPIGVDDDLRSEAISKICQENGKVDPECFVNCQRYVLEKMESEYFLVFRDSAFYCRHQVHMLTTEKVFLPDILLNENALCYFMEYMEQDGGSDLMQVWLCASNFQQQLQATRGSYDPVQAQTDAMVIYDKYFSLQATNPVGFDDKLRFEIESNICREEGPLPDCFTKAKNIVLKMLEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SXU0</accession>
    <name>A0A433SXU0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase II N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_018119</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000864">
        <property type="protein sequence ID" value="RUS74112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SXU0"/>
    <dbReference type="STRING" id="188477.A0A433SXU0"/>
    <dbReference type="OrthoDB" id="9995526at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039048">
        <property type="entry name" value="Trub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13195">
        <property type="entry name" value="PSEUDOURIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13195:SF0">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE TRUB2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pseudouridine synthase II N-terminal" evidence="3">
        <location>
            <begin position="108"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="352"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS74112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="431" mass="47886" checksum="76EFE8B73DD6D986" modified="2019-05-08" version="1">MSRFNWAPTAYRLLDGLFCVYKPAGVPVHKVIHSVKLNLCKDLNALPCYEHEIALGQTAVRENLSTKSISLNAEPGGITDWSEHRLVLGDRYEDSDFNIHFVDGISKNSTGVLVMSVGRFGRQSLEMVALSKFLRVYHVKGRLGYATDDFSPTGHFIERTSFKHVSLSKLTRLCSATQAAHTRQMYNMHGVNPDSQAAYEMAARGIVRPRERRTMPVVYSIKCIDFQPPDFTLEIHSINETCQFLRQLIHDMAVKLKSSAVCTGIRRLRYGHFDTERALLRQHWRLDQIVDNIRDNMDLLEPDKLFVGTGAEESQALLPGNAQERLRLSDNIDSGSDGSLELTDSGGAYRSEGLLEMSDSGDSKSKESLKMLKNGGLQSDGSPTLLEPENSSTKSGGSDFVCDDESSFKSDAGTKNSPEFITSGYKKSKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SYL1</accession>
    <name>A0A433SYL1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L-serine deaminase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">L-threonine dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_017837</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000834">
        <property type="protein sequence ID" value="RUS74402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SYL1"/>
    <dbReference type="STRING" id="188477.A0A433SYL1"/>
    <dbReference type="OrthoDB" id="4418812at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000005">
        <property type="entry name" value="Threonine dehydratase catabolic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF6">
        <property type="entry name" value="L-THREONINE DEHYDRATASE CATABOLIC TDCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="7">
        <location>
            <begin position="23"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS74402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="328" mass="34596" checksum="9EE215CD73F0F22A" modified="2019-05-08" version="1">MEKEVNEVTLQDIQQARERIAGSVTKTPLVPLNQDSKGTPSREIFLKLENLHPIGSFKIRGACNAICTIPIEKLKDGVYTASAGNFAQGLAWNARQLGVPCSVVMPDHAPEAKVKPTLDMGAGVTKVKFDKWWEVVVNRKYEHFKGSFIHPVSESSVIAGNGTIGMEILEDLPSVDTIIVPYGGGGLSSGIAIAAKGLKPSVKVYACEVETAAPLSAALKKGERVKCKYTPSFVDGMGSSEVLEEMWPLVKRVLDGSLVVSLRQVADSVKLLAEKNHVIAEGAGAAPVAAALSGAAGDGKIVCVVSGGNIDASKLVPILQGFVPGEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SZ24</accession>
    <name>A0A433SZ24_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_017675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the learning-associated protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000819">
        <property type="protein sequence ID" value="RUS74569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SZ24"/>
    <dbReference type="STRING" id="188477.A0A433SZ24"/>
    <dbReference type="OrthoDB" id="6257894at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001099">
        <property type="term" value="F:basal RNA polymerase II transcription machinery binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097484">
        <property type="term" value="P:dendrite extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018784">
        <property type="entry name" value="LLPH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34253">
        <property type="entry name" value="PROTEIN LLP HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34253:SF1">
        <property type="entry name" value="PROTEIN LLP HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10169">
        <property type="entry name" value="LLPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="72"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS74569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="113" mass="13111" checksum="BCDB9CE9867F08D7" modified="2019-05-08" version="1">MAKSIRSKHKRKMRNVKREHFSKRGLENLKRIAAQDAEALKEIATMKPAEEVMAEAKAKADAMEVDKAAKVFSKKTKQDEHGHYPEWMNQRAVKKQKKKLAKSKKKPGKKIKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SZH2</accession>
    <name>A0A433SZH2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_017522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000806">
        <property type="protein sequence ID" value="RUS74713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SZH2"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS74713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="285" mass="32105" checksum="82EA2F5CD435EBB7" modified="2019-05-08" version="1">MVEMIKPEKPDDVRRARLKFRLSRLFDLACMLTRSSLPSPETLDAGALQIARARFSPDETFLAVLPKKGKQNKREGQARWTSESEDGKASRPQRAFSACFIRWRKAIITTVHRDHHIKPRADISTPCQDQVVKILVEPGGANYDADAECRHGEHGNHIGDQSERCLRLTQPMGDQENLMPSCCDCVIHHRPVYRKASNPEMVFGYTGWVNQRMSKSPRKPVKSESGFYPVTPDIPPAPPLLCPCCVFLNKLVFLVWGYTNIRGNDDKELAFSTRSSPSPGTTSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T2M1</accession>
    <name>A0A433T2M1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_016486</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000714">
        <property type="protein sequence ID" value="RUS75760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T2M1"/>
    <dbReference type="OrthoDB" id="6043889at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="874"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="876"/>
            <end position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS75760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1169" mass="124249" checksum="0E94310788E06F81" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T469</accession>
    <name>A0A433T469_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Copper homeostasis protein cutC homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_015909</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000671">
        <property type="protein sequence ID" value="RUS76321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T469"/>
    <dbReference type="STRING" id="188477.A0A433T469"/>
    <dbReference type="OrthoDB" id="7392499at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.380">
        <property type="entry name" value="Copper homeostasis (CutC) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005627">
        <property type="entry name" value="CutC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036822">
        <property type="entry name" value="CutC-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598">
        <property type="entry name" value="COPPER HOMEOSTASIS PROTEIN CUTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598:SF0">
        <property type="entry name" value="COPPER HOMEOSTASIS PROTEIN CUTC HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03932">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110395">
        <property type="entry name" value="CutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS76321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="200" mass="21887" checksum="BE13E3A2C7E4D704" modified="2019-05-08" version="1" fragment="single">LGMLKVIKKLVSIPVFVMIRPRGGDFCYTSTELQIMKEDIMSLKEAGADGFVLGILTRYFMPSSKGKIWKLCCPLPATFHRAIDMSRDVSSSLAKIIKLGFSRVLSSGGSQTALEGVKVLEAMVFQVRGGLTPGNLAEVLQVTKAREFHGSARIPVKSVMTFMNSQVCMGTEANCEYLRKVTSAELVSSFLKIAHDCWGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T6Y0</accession>
    <name>A0A433T6Y0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_014879</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000586">
        <property type="protein sequence ID" value="RUS77365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T6Y0"/>
    <dbReference type="STRING" id="188477.A0A433T6Y0"/>
    <dbReference type="OrthoDB" id="5141738at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17317">
        <property type="entry name" value="MFS_SLC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="25"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS77365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="550" mass="61962" checksum="91A3FCB9F9350EC5" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T7I1</accession>
    <name>A0A433T7I1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_014693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000573">
        <property type="protein sequence ID" value="RUS77539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T7I1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS77539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="112" mass="12365" checksum="1AE5B9BE1233E956" modified="2019-05-08" version="1">MEKKNPSKLIAVYKMSRNLWYQHHQLSEDTSSSRTCTMSPSRSSETASTTEPREDLIRSVISPTARISLESSIATLAASTILLIITSPRSSATSPNFSLSFCLIVDNLPRMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T8D0</accession>
    <name>A0A433T8D0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_014401</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000547">
        <property type="protein sequence ID" value="RUS77849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T8D0"/>
    <dbReference type="STRING" id="188477.A0A433T8D0"/>
    <dbReference type="OrthoDB" id="2153609at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058897">
        <property type="entry name" value="PAPPA_SD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25900">
        <property type="entry name" value="PAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="198"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS77849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="362" mass="40477" checksum="A887FF4D424BEDE8" modified="2019-05-08" version="1">MAASAPPMYSHTYQRDPDGPPPYHPSAIKQWAARVENFSSQYNNSTWSATQALGQPKVYPQHGDFHGAWAQGAIDENQYIELEFDVPVCPTAINIYETYNPGAVTAIKFMDSKGKWDTLWSTTKTLVLTQSRIFSPPLKDTTSTTTQVRIEMNCKPARTWCEIDAVELVGIREGAVRPVDDTDFVANLQGLINNKEFSDVKFEIDGQKLYAHKAILAARSKYFSDMFRGKNQDSVVLKIPSVSSTDMLAIFHFIYTNRIPRDSKIKSLITLTGVSSILGMPHLKTAAMYRLLESMTCNNVVDIVLELVEKDDDEVQEMCLRFIADNLADVSKAPGFNKLPQSFLVRAVQEATANMCITSRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TAG9</accession>
    <name>A0A433TAG9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_013665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000502">
        <property type="protein sequence ID" value="RUS78558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TAG9"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS78558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="268" mass="29541" checksum="A1E3A7020FE5919D" modified="2019-05-08" version="1" fragment="single">MNSASRPPDPELLGFLQTLVNEGQGPSQQAERTDSDKENEQARMKEGQQLRSSGDGAASSSKRTDDAMWDDFYNDEDFKPNSKGPTVPSQAPEGLSVSSDHNAADDDYGRDRFESLERVEEEEEDDDDHDDSNAAAKKDNSTSDPAASNSQGRQENNESYSSSGDSKPKKKRRLFTRVKRPASTKNTPDLFAPTASGGSHPDLSNGRGQNASLHLYSQQETMSETSGRSGRRLSRRKQVARPRCAGPQPSGDLLQQKYQELQMLMVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TAR4</accession>
    <name>A0A433TAR4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hexosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_013626</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="RQTK01000499">
        <property type="protein sequence ID" value="RUS78620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TAR4"/>
    <dbReference type="STRING" id="188477.A0A433TAR4"/>
    <dbReference type="OrthoDB" id="6381420at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF364">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS78620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="403" mass="46093" checksum="A332CA1EAF2876D7" modified="2019-05-08" version="1">MNLRIGKVRNSLILVVVLVVNVLCLLSITIQSYSAWRPGRAAGTTTPAGGGDLYSSEHQHKNHGVDVQSASASFLPPSPTAYLNLSMNPAVLKKVDSMHHVLNLSRFDDDTVYPAKRVGRYLIVYPGLCADVDRVHLIMIVHTAPKNLHRRQRIRETFGNRALFYPFNVRVAFLLGKTLNSTLERVLWMEHARYNDTVMGDFVDDYHNLTLKGVMGYRWVNQHCQNSELVLKIDDDVFINTYKLLYSFINHMRGKPKSIFCNMWHKGTMPILREGKWKVDTRMFSKMSTFPYDYCSGFVVLLSSDLMGPMHQAATTTPFFWIDDVYLFGMLPSVVGGVTFYNYALDKNVSLNDKKTINCTMEQGARCPIFGSIIADHNYWRYWQMVSSLYVSGDWKVENKLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TFE2</accession>
    <name>A0A433TFE2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_011950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000401">
        <property type="protein sequence ID" value="RUS80266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TFE2"/>
    <dbReference type="OrthoDB" id="10571339at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS80266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="120" mass="13428" checksum="7C87D2113F0F1F92" modified="2019-05-08" version="1" fragment="single">AVGLHRDMQDLRAVSVHTDLQDLRAVGLHTDMHYLRAVGLHTDMHYLRAVGLHTDMKNLRAVGLNTDLQDLRAVGLHTDLQDLRAVGLQTDLQDLRAVGLQTDLQDLRAVGLHTDLQDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TIZ2</accession>
    <name>A0A433TIZ2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NTF2-related export protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_010687</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000331">
        <property type="protein sequence ID" value="RUS81557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TIZ2"/>
    <dbReference type="STRING" id="188477.A0A433TIZ2"/>
    <dbReference type="OrthoDB" id="25408at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000006">
        <property type="entry name" value="NTF2-related export protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045875">
        <property type="entry name" value="NTF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12612">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="5">
        <location>
            <begin position="15"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS81557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="134" mass="14745" checksum="D6E8DDBE448418E8" modified="2019-05-08" version="1">MAMSLQARQAQANTAADEFSKIYYETFDKRRQAISKLYQDKANVVWNGNAVAGSDAIIKLFDGLPSSEHTVDGLDTQPIVAGPVDADNTNSIMVTVFGKVKFKDTGAEAFTQTFILSAAENKWKIISDTFRFVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TJ16</accession>
    <name>A0A433TJ16_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_010669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000330">
        <property type="protein sequence ID" value="RUS81568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TJ16"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS81568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="371" mass="46750" checksum="09D8DB940B661563" modified="2019-05-08" version="1">MIPKLLWETLESSFEQGKGTKCIKPGLLGNKSQSIGSCGRLRQTEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEKEEEEEKEENNLAPMFNYYYLFCFFLLPIKKKEMKTIIPLSHCSKYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TKF8</accession>
    <name>A0A433TKF8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_010228</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000309">
        <property type="protein sequence ID" value="RUS82001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TKF8"/>
    <dbReference type="STRING" id="188477.A0A433TKF8"/>
    <dbReference type="OrthoDB" id="272703at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051183">
        <property type="entry name" value="U1_U11-U12_snRNP_70-35kDa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952:SF5">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS82001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="176" mass="19532" checksum="C0DB78D2B2321CD5" modified="2019-05-08" version="1" fragment="single">NYDTSESKLRREFEVYGAVKKISLINDRNTGKPRGYAFIEYEHERDMHYGLFARVAGGRRSLQSLSVWVAGGVLATGPSLPPYSTTTTSTTTSTSLKHSTTTTTNHTIHSYVVLTPLGLDLSIGLYVRGFVLLAAVRPKLSLCRDAHTVALTLILIPVHTMIHFRKEGRGVCWRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TM94</accession>
    <name>A0A433TM94_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear transcription factor Y subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_009544</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NFYA/HAP2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000275">
        <property type="protein sequence ID" value="RUS82707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TM94"/>
    <dbReference type="STRING" id="188477.A0A433TM94"/>
    <dbReference type="OrthoDB" id="1097733at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018362">
        <property type="entry name" value="CCAAT-binding_factor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001289">
        <property type="entry name" value="NFYA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12632">
        <property type="entry name" value="TRANSCRIPTION FACTOR NF-Y ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02045">
        <property type="entry name" value="CBFB_NFYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00521">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00686">
        <property type="entry name" value="NFYA_HAP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51152">
        <property type="entry name" value="NFYA_HAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS82707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="112" mass="12152" checksum="D2B31A1F8AACE762" modified="2019-05-08" version="1" fragment="single">NLLQSVVQAQPAQQATVPSVGTSNPVNAVAGGAIPQMLFLSQVTINGQTSFVLVDKNHMPVQLPQGKENGTQPPTDTGDEPLFVNAKQYHRILKRREARAKLESQGKIPKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TP55</accession>
    <name>A0A433TP55_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DM2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_008922</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000249">
        <property type="protein sequence ID" value="RUS83300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TP55"/>
    <dbReference type="STRING" id="188477.A0A433TP55"/>
    <dbReference type="OrthoDB" id="10263741at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17674">
        <property type="entry name" value="SWIB_BAF60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038041">
        <property type="entry name" value="SMARCD1_SWIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DM2" evidence="2">
        <location>
            <begin position="275"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS83300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="503" mass="57738" checksum="EDBF755A5CDDA9AB" modified="2019-05-08" version="1">MQGGPPRYASQSPAMRPSYPQGPYSSSPRPGFPQMAPGRMGMPGPGMSPHPPYAGTPVKTKDASCNTSSKSKESGSMPRAGAGMPPPPPGMDRKRPAAQEVRPPQQMKSKRKKKIADKILPQRVRDLVPESQAYMDLLAFERKLDATIMRKRLDIQEVLKRPMKVSQISLFKTHSSLFRLIKEGEESVPSWELRVEGRLLEDAASAKLSDSNKIKRKFSSFFKSLVIELDKELYGLDNHLVEWHRTPSTQETDGFQVKRPGDQNVKCKVLLMLDYQPMQFKLEHRLARLLGIHTQTRPFIVNALWQYIKTHKLQDSSEREYINCDKYFEQIFECKRLKFSDIPAKLQPLLMPPDPIIIHHVVTVEGPDAKKTACYDIDVDIDDTLKQQMNSFVMSTQNHTEISNLDSKIHETVENINMLKTQREFFLGFAKDPQEFISNFLISQTRDLKTMTDVVGNPEEERRADYFFESWTNEGVNRYIYSLVQQRRQQLEQALMMRNNGSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TPR7</accession>
    <name>A0A433TPR7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_008664</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000239">
        <property type="protein sequence ID" value="RUS83558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TPR7"/>
    <dbReference type="STRING" id="188477.A0A433TPR7"/>
    <dbReference type="OrthoDB" id="6081913at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000036">
        <property type="entry name" value="CYtochrome P450 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF403">
        <property type="entry name" value="CYTOCHROME P450 306A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS83558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="506" mass="57637" checksum="448D4503E6981C4B" modified="2019-05-08" version="1">MAHETPGRAEDQTNHALTYLALSLGLVWLVKHLVSSRAPANIPPFPAKPYPIIGHLPYFKNGLKDQLTAWRKSTGEIFSVYFGPNLVVILGSHGVLHQAFVKRGDTLSDRPLSVAAASRGRDINRGIVFSSGRVWKEQRSVSLQILRSFGLGQNILAAKISEEVSMFLDSLSKLFGEPTDVRMLIKSMVANNLCSIVVGQRFEYNDERFLTLLHKMSEMFRLGQSSGMCTIFPWLSRLPGDLFNSRARFQVYQYILDQYCYHYIEKTKNEERDLTQDNFIFAYLQEMKKRQQQGQDTTLDEDNLALNVMNMFAAGTDTTSAAISWFMLAMLHYPDVQEKIFVEISEVVGLDRAVTMHDRAKLNYTQAAIMETQRFFVSPLGVPHKASKDTIINGYTIPAGTTVMACIHNIFHCQELWKDPDQYRPERFLDADGNISPPEFFTPFGIGRRVCPGESLAKMELFLVLASVIQRFELRPTTPDHLPTQKPEIGMIYFPQPYQIRFVERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TY04</accession>
    <name>A0A433TY04_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphomevalonate kinase</fullName>
            <ecNumber evidence="3">2.7.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">EGW08_005765</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">EC2010</strain>
            <tissue evidence="18">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.2" evidence="3"/>
    <dbReference type="EMBL" id="RQTK01000138">
        <property type="protein sequence ID" value="RUS86450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TY04"/>
    <dbReference type="STRING" id="188477.A0A433TY04"/>
    <dbReference type="OrthoDB" id="2401875at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004631">
        <property type="term" value="F:phosphomevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005919">
        <property type="entry name" value="Pmev_kin_anim"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13101">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13101:SF1">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04275">
        <property type="entry name" value="P-mevalo_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0152">Cholesterol biosynthesis</keyword>
    <keyword evidence="6" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="15" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RUS86450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="121" mass="13893" checksum="947B0A29B124DE49" modified="2019-05-08" version="1">MIDWGEKRRKKDPSFFCQLATSEGSNKKVWVISDARRLTDVDYFRQRYSNATITLRVECDIATREERGFNFTKGVDDAESECGLDTGVTWDILMHNNGNKEELDKGLEKILESIALKCEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TY55</accession>
    <name>A0A433TY55_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metalloendopeptidase</fullName>
            <ecNumber evidence="2">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_005806</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1 2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="2"/>
    <dbReference type="EMBL" id="RQTK01000139">
        <property type="protein sequence ID" value="RUS86428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TY55"/>
    <dbReference type="STRING" id="188477.A0A433TY55"/>
    <dbReference type="OrthoDB" id="6061307at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF850">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="3">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS86428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="74" mass="8788" checksum="8EEDABB9AA3AC036" modified="2019-05-08" version="1" fragment="single">QKRILIHELGHVIGLIHEHQRHDRDKYVKVMLEHVRNTSQERWFTKLLSGSITDKAVKYDYTSVMHYGKNVSCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TYN9</accession>
    <name>A0A433TYN9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Temptin Cys/Cys disulfide domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_005546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000131">
        <property type="protein sequence ID" value="RUS86672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TYN9"/>
    <dbReference type="STRING" id="188477.A0A433TYN9"/>
    <dbReference type="OrthoDB" id="129121at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057626">
        <property type="entry name" value="S-S_Temptin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055313">
        <property type="entry name" value="Temptin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34737">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34737:SF2">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24784">
        <property type="entry name" value="Temptin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019328495" description="Temptin Cys/Cys disulfide domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Temptin Cys/Cys disulfide" evidence="2">
        <location>
            <begin position="16"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS86672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="127" mass="13499" checksum="AD1E78E895F6A25C" modified="2019-05-08" version="1">MLKLLALSLCVATVLGLPSYRSRIPNGYAVPSPCDDGLWRGVGHFLDYGSGPLNHFGEAFLLNDFVWDETLCRLDSDKDGVPNGVELGDPDCQWSLVNQTALSPATGHPGICEPVGSAECANSGFTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U0M2</accession>
    <name>A0A433U0M2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Basement membrane-specific heparan sulfate proteoglycan core protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_004892</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000113">
        <property type="protein sequence ID" value="RUS87350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U0M2"/>
    <dbReference type="STRING" id="188477.A0A433U0M2"/>
    <dbReference type="OrthoDB" id="10055367at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048646">
        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048667">
        <property type="term" value="P:cell morphogenesis involved in neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016358">
        <property type="term" value="P:dendrite development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001764">
        <property type="term" value="P:neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000172">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF85">
        <property type="entry name" value="SP2353, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00054">
        <property type="entry name" value="Laminin_G_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="47"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="130"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="8">
        <location>
            <begin position="222"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="394"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="434"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="8">
        <location>
            <begin position="477"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="678"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="717"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="403"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="705"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="745"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS87350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="841" mass="93108" checksum="C7DE72515A4691C0" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U1T5</accession>
    <name>A0A433U1T5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Band 7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_004448</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000101">
        <property type="protein sequence ID" value="RUS87783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U1T5"/>
    <dbReference type="STRING" id="188477.A0A433U1T5"/>
    <dbReference type="OrthoDB" id="434619at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08829">
        <property type="entry name" value="SPFH_paraslipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000008">
        <property type="entry name" value="Stomatin-like protein 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050710">
        <property type="entry name" value="Band7/mec-2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032435">
        <property type="entry name" value="STML2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327:SF10">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16200">
        <property type="entry name" value="Band_7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="4">
        <location>
            <begin position="35"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS87783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="343" mass="38227" checksum="3BD8DC343249C3E7" modified="2019-05-08" version="1">MLRSVVNRNSTNLLKATVEHAQQCVRNRSRLPLNTVILFVPQQEAWVIERFGKYKQILQPGLNVILPVIDSIKYVQSLKEIAIDVPHQAAITSDNVTLTIDAVLYLRVFDPYKASYGVEDPEYAITQLAQTTMRSEIGKIALDTVFRERELLNIAIVDSINHASNSWGIKCMRYEIRDMTLPPKVQEAMQMQVEAERKKRAFILESEGKREADINVAEGKKRARILNSEAFMTEQVNQAKGEAEAQIVNAQARATSIDLVAQALQKENGMNAVSMNVAEQYVTAFGNLAKESNTVILPANSGDVAGMVTQALTMYKTLSNTTNKQLDVKETKAEQSPSGNEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U4V2</accession>
    <name>A0A433U4V2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_003378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000072">
        <property type="protein sequence ID" value="RUS88833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U4V2"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS88833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="213" mass="22387" checksum="0A1D6FB914414C79" modified="2019-05-08" version="1" fragment="single">VDENVIIWAGLDDFALPAAKEALHFLFVSLQHGQERLGVHVVSSVVFGYAWVDVGSPGPVDDVALDRVIFVVGDVVVHHDHDLLVRDAVGVGDLVGVAHVRLVPVVPVPVRAGDEQDPVLPGGGRARDQAQRNQEGGAIGEEGGSHDGQIGLVKLVPAMSRTQFFLAAATPGATSATTRRADTQAGTDTPIMLCGVWLGVLTSELAFFVHNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U569</accession>
    <name>A0A433U569_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-processing factor 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">PRP6 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">U5 snRNP-associated 102 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EGW08_003222</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">EC2010</strain>
            <tissue evidence="17">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000069">
        <property type="protein sequence ID" value="RUS88975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U569"/>
    <dbReference type="STRING" id="188477.A0A433U569"/>
    <dbReference type="OrthoDB" id="440128at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000649">
        <property type="entry name" value="mRNA splicing factor (Prp1/Zer1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000054">
        <property type="entry name" value="Pre-mRNA processing factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000058">
        <property type="entry name" value="Pre-mRNA processing factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:003529">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010491">
        <property type="entry name" value="PRP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06424">
        <property type="entry name" value="PRP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="PRP1 splicing factor N-terminal" evidence="16">
        <location>
            <begin position="19"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Suppressor of forked" evidence="15">
        <location>
            <begin position="333"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="25"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="104"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF05843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF06424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RUS88975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="931" mass="105129" checksum="442BEBF73A0EC79E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U944</accession>
    <name>A0A433U944_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_001919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000035">
        <property type="protein sequence ID" value="RUS90321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U944"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS90321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="237" mass="27959" checksum="0A6CE86A0D0C6BF5" modified="2019-05-08" version="1">MQVTLLLMMNDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDVLSYSGIQIVQRDTDREIQIVQRDTDREIQIVQRDTDREIQIVQRDTDRAVRYRSRDTDRAVGYRSYSGIQIVQRDTDRAAGYRSCDTDREIQIVRYRSCSGIQIVQRDTDLEIQIVRYRSCSEIQIVQRDTDRVIQIVRYRSCCRIQIVQWDTDRAAGYRLCSEIQIVQRDTDRVAGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UBU9</accession>
    <name>A0A433UBU9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_000988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000015">
        <property type="protein sequence ID" value="RUS91276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UBU9"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS91276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="257" mass="27899" checksum="35D8FFCF4858692D" modified="2019-05-08" version="1">MPCNMRGQQDKENTTPPRERIRVTRDIPDRGLGSLPRPIAVVTPISAPLSEGDSGNRPGAEPLTLPQPPVIGLFRTDSSLSGSSNDADLHDSSDEMDPEQGYETPLRFQSFMSSVNVLLGPDSVFERLSQEGSARTSPVIADRYRSREPLPPISSLLRSRAVPDCANKQTLIAPRPISPELKPSEMSESESAEAIIEVCSRGVSMNSLRLDTIPEEPIQSVPLDLSVSASSQNADNQAPRCTYDNNNNTRGPRPEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UBW0</accession>
    <name>A0A433UBW0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Receptor protein-tyrosine kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EGW08_000858</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">EC2010</strain>
            <tissue evidence="17">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000013">
        <property type="protein sequence ID" value="RUS91341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UBW0"/>
    <dbReference type="STRING" id="188477.A0A433UBW0"/>
    <dbReference type="OrthoDB" id="2431000at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07459">
        <property type="entry name" value="CRD_TK_ROR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000107">
        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041775">
        <property type="entry name" value="Ror-like_CRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000615">
        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0770">Synapse</keyword>
    <keyword evidence="2 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="15">
        <location>
            <begin position="167"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="399"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="84"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="659"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="668"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="693"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RUS91341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="720" mass="79381" checksum="2DF2C0EE45807C70" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UBX1</accession>
    <name>A0A433UBX1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_000910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000014">
        <property type="protein sequence ID" value="RUS91296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UBX1"/>
    <dbReference type="STRING" id="188477.A0A433UBX1"/>
    <dbReference type="OrthoDB" id="6259853at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013256">
        <property type="entry name" value="Chromatin_SPT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22691:SF8">
        <property type="entry name" value="PROTEIN SPT2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22691">
        <property type="entry name" value="YEAST SPT2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08243">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00784">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="316"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="388"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="482"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="720"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="73"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="191"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="322"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="334"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="454"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="499"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="533"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="590"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="609"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="655"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS91296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="750" mass="83053" checksum="DA4710B7C840DC42" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UDE8</accession>
    <name>A0A433UDE8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_000490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000006">
        <property type="protein sequence ID" value="RUS91782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UDE8"/>
    <dbReference type="OrthoDB" id="8960888at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS91782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="199" mass="20603" checksum="D5319D59DD27AF4F" modified="2019-05-08" version="1">MTTDLNSTSASIPLSPSFLPFSRASPLLTPAHLASPLLTPAHLASPLLTPAHLASPLLTPAHLALPLLTPAHLVSPLLTPGHVASHLLTPTHLTPAHLASPFFTPAHLASPLLTPTHITPAHLASPLFTPANLASPLLTPTHLTPAHLASPLFTLTHLTPDHLASPLFTPAHLASPLLTPAHLASPLFIPAHQASPLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UDY3</accession>
    <name>A0A433UDY3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_000258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000003">
        <property type="protein sequence ID" value="RUS92045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UDY3"/>
    <dbReference type="OrthoDB" id="6150953at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS92045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="133" mass="15840" checksum="6095F6E6390EBDAB" modified="2019-05-08" version="1">MLQLYRTIILRTTGLQDYRTTGLKDYRTTELQDFRATGLQDYRTSGLQDYRTTGLQDYRTTRLQNFRTSGLQDYRVTELQDYRATELQGYRTSGLQDYRTTELQDYMTTGLQDYRTTELQDFRTSGLQDFRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UEM4</accession>
    <name>A0A433UEM4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_000087</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000001">
        <property type="protein sequence ID" value="RUS92234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UEM4"/>
    <dbReference type="STRING" id="188477.A0A433UEM4"/>
    <dbReference type="OrthoDB" id="870at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14837">
        <property type="entry name" value="AP3_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000012">
        <property type="entry name" value="AP-3 complex subunit mu-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="9">
        <location>
            <begin position="177"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS92234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="418" mass="47231" checksum="6DFB8C7A2AC46DB6" modified="2019-05-08" version="1">MIHSLFIINSTGDVFLEKHWKSVVNKSICDYFFEAQSRQTNPEDVPPVIATPHHYLINIYRSSLYFVAVVTTEVPPLFVIEFLHRICDTFEDYFSDCNETILKEHFVIVYELLDEMLDNGFPLAVESNVLKELIKPPNFLRTITDTVTGKSTGVSATLPTGQLSNIPWRRTGVKYTNNEAYFDVIEEIDAIIDKSGTTVIAEIQGYIDCLIKLSGMPDLTLSFVNPRLLDDVSFHPCVRFKRWEAEKILSFVPPDGHFRMMSYHIGTNNMVAIPVYLRHNISFREGGGGRFEVTIGPKQTMGKPVENVVLEVPFPKSVLNVTLTCSQGKNSFDPVSKLMTWDVGKIDPSKLPNIKGNITLQTGVPIPESNPTITVMFTIQQMAVSGLKVNRLDMYGEKYKPFKGVKYITRAGKFQVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z634</accession>
    <name>A0A3S0Z634_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_022113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001485">
        <property type="protein sequence ID" value="RUS70129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z634"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS70129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="199" mass="21890" checksum="02056AF1B760ABDC" modified="2019-04-10" version="1">MIGGEVIVAQNSVQVCEAKPGLSAGDRRIELKTTEADDVLSSQHTVLCVRPANPLHLRLQFKITETRDRNAFQHCRLAVRPSAGLWSTLLVNDSRSTCPVVVSAELSTRQVCEAKPGLSAGDRRIELKTTEADDVLSSQHTVLCVRPANPLHLRLQFKITETRDRNAFQHCRLAVRPSAGLWSTLLVNTGATIVGRHVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z8T1</accession>
    <name>A0A3S0Z8T1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_022794</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001681">
        <property type="protein sequence ID" value="RUS69442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z8T1"/>
    <dbReference type="STRING" id="188477.A0A3S0Z8T1"/>
    <dbReference type="OrthoDB" id="114727at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000079">
        <property type="entry name" value="Calcium and integrin-binding family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051433">
        <property type="entry name" value="CIBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45791:SF1">
        <property type="entry name" value="CALCIUM AND INTEGRIN BINDING FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45791">
        <property type="entry name" value="CALCIUM AND INTEGRIN BINDING FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="98"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="140"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS69442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="183" mass="20841" checksum="A502AAB5F1B1494C" modified="2019-04-10" version="1">MGGSQSVFTEEELDDYQTLTYLSKKEILHVFKRFKSLAPGLVDANKNVKLPLSKITEMPELKVNPFRDQICKVFSSSGDGMTFEDFLDMMSVFSDGAPKNVKVEYAFRVYDFDGDDLISDTDLQNVIEKLTGANQLSEADMQQLIENIMEEADLDDDKTLSFAEFEHVISKAPDFVNSFRFRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZCN2</accession>
    <name>A0A3S0ZCN2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_020327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001141">
        <property type="protein sequence ID" value="RUS71914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZCN2"/>
    <dbReference type="STRING" id="188477.A0A3S0ZCN2"/>
    <dbReference type="OrthoDB" id="5985714at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01472">
        <property type="entry name" value="vWA_collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01450">
        <property type="entry name" value="vWFA_subfamily_ECM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF20">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="8"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="212"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="409"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="597"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS71914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="790" mass="86117" checksum="2330FE547D1E61C2" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZEP1</accession>
    <name>A0A3S0ZEP1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_018980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000958">
        <property type="protein sequence ID" value="RUS73261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZEP1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS73261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="99" mass="11343" checksum="AF4E9892B065A45D" modified="2019-04-10" version="1" fragment="single">IQNTHTTCAAQHTEYPHNTRSATYRIPTQHAQRNIQNTHTTRAAQHTAEIVIRVTTVWGGTKHRASSYRIPTQHAQCNIQRAHKLPYAIPHPYLTIDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZHG2</accession>
    <name>A0A3S0ZHG2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_013244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000478">
        <property type="protein sequence ID" value="RUS78987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZHG2"/>
    <dbReference type="OrthoDB" id="6158499at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029138">
        <property type="entry name" value="SNAPC5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15497">
        <property type="entry name" value="SNAPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS78987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="156" mass="17515" checksum="5A596C2518543264" modified="2019-04-10" version="1">MATPNINYFKEKLVLREEEKSLKEMLAKFQDQLNRLKIEELALLSHIKLQQEKCAGVGPGNVQSRPGLRKSRDTPSEGGSSVSSAIPVGVMQYKKQAKHAGEEELDLAVTRHSHLGLDQDFGEEEEEEEEEEEDDEEEGEGLNDDDNPLLSYMDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZHJ8</accession>
    <name>A0A3S0ZHJ8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_014438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000551">
        <property type="protein sequence ID" value="RUS77799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZHJ8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS77799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="116" mass="12711" checksum="91D9EA502A1E38AB" modified="2019-04-10" version="1">MMFSAICSNLLLNRDLSLSPSLSLSLSLSLSLSLFFFFSFFPFFSLCMGLRLLAFPEGPYTAVPGLSTDYFNDIFINPLIPAAKLPISKAMTMVLYNLKGLFGVNDNHVSIPTGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZLL7</accession>
    <name>A0A3S0ZLL7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_014501</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000556">
        <property type="protein sequence ID" value="RUS77742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZLL7"/>
    <dbReference type="OrthoDB" id="6154407at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888:SF1">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888">
        <property type="entry name" value="ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS77742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="458" mass="50257" checksum="1406202B8391C9E5" modified="2019-04-10" version="1">MKVFDGNGDVGAWLQKAELVAKLTGVKDIATFLPLYLEGSALALYLELSDAEKSDEEVLKQRLLEAFSDSRFTAYCKLKVARWDGEPVDVFANDIRKLARESGFVKEGLEEVVKLAFVTGFPDSISAELQQIQGVDNMRVSDILSRARVLASRPRSGSSIQGVVATGVDAAKDGKKERLKCYKCNGPHLMRDCPDIQCFKCGLDGHMANRCKTRNTTSSNRDKSKDNVCARADSGGSSIHKVPLIEVAVNGTKCQAMVDTGCTMSLVKCHLVSSWSGESTMVAFDGHAVKCKGVAEVALTVGGRDTTAVVTVVDQIVGGVQAVIDGVPPKLTNKVALYDHGVKAETKEAFESEVQRWIEEDILVPWNGEVEGIIPLMGVEQVTKKKVRPVLDFRDLNTYVECHTGGDCMDVCSERIREWRQIEGDAEVVDLKSAYLQIHVAEELWKHQLVRCVPCQIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZMC2</accession>
    <name>A0A3S0ZMC2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="22">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">EGW08_021483</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">EC2010</strain>
            <tissue evidence="27">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17 22">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 21">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 22">Membrane</location>
            <topology evidence="2 22">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 22">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="22"/>
    <dbReference type="EMBL" id="RQTK01001340">
        <property type="protein sequence ID" value="RUS70751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S0ZMC2"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090556">
        <property type="term" value="F:phosphatidylserine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000021">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000010">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF150">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
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    <keyword evidence="12 21 22" id="KW-0460">Magnesium</keyword>
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    <keyword evidence="10 20 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 22" id="KW-1278">Translocase</keyword>
    <keyword evidence="8 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 22" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="362"/>
            <end position="380"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="908"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="946"/>
            <end position="965"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="986"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1027"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1060"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1094"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="25">
        <location>
            <begin position="103"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="24">
        <location>
            <begin position="195"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="26">
        <location>
            <begin position="878"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="19">
        <location>
            <position position="473"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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    <feature type="binding site" evidence="21">
        <location>
            <position position="473"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
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        <location>
            <position position="474"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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        <location>
            <position position="475"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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    </feature>
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        <location>
            <position position="475"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
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        <location>
            <position position="558"/>
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        <ligand>
            <name>ATP</name>
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        <location>
            <position position="599"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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        <location>
            <position position="622"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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        <location>
            <position position="655"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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        <location>
            <position position="735"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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    <feature type="binding site" evidence="20">
        <location>
            <position position="736"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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        <location>
            <position position="737"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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        <location>
            <position position="825"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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        <location>
            <position position="831"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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        <location>
            <position position="851"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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        <ligand>
            <name>ATP</name>
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        <ligand>
            <name>Mg(2+)</name>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051303"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
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    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="RUS70751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1284" mass="144370" checksum="D7810448DFFAD4B8" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZNE0</accession>
    <name>A0A3S0ZNE0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_010376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000317">
        <property type="protein sequence ID" value="RUS81853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="188477.A0A3S0ZNE0"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS81853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="154" mass="16392" checksum="317871858C0A2086" modified="2019-04-10" version="1" fragment="single">MLPLRERMSIPVSFNHISLASMLSVVSKAVSLNHISLASMLSVVSKAVLLNYISRASMLSVVSKAVLLNYISLASMLSVVSKAVLLNYISLASMLSVVSKAVSFNHISLASMLSVVSKAVSFNHITRASMLSVVSKAVSFNHFSQASMLSVVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZRH6</accession>
    <name>A0A3S0ZRH6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_018672</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
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            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000922">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="188477.A0A3S0ZRH6"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS73581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="115" mass="11451" checksum="7A5A64FE9053FC43" modified="2019-04-10" version="1" fragment="single">CACYPSRGDTCACIIQGSDTCACIKQGGDTCACIIQGGDTCACIIQGGDTCACIIQGGDTCACIIQGGDTCACIIQGGDTCACIIQGGDTCACIIQGGDTCACIIQGCLYHKVQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZU83</accession>
    <name>A0A3S0ZU83_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein 232</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_005412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000127">
        <property type="protein sequence ID" value="RUS86816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZU83"/>
    <dbReference type="STRING" id="188477.A0A3S0ZU83"/>
    <dbReference type="OrthoDB" id="10016194at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031747">
        <property type="entry name" value="TMEM232"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28651">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28651:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15877">
        <property type="entry name" value="TMEM232"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="425"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS86816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="910" mass="100640" checksum="DB2B48ADCEA17CFD" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZUQ3</accession>
    <name>A0A3S0ZUQ3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_008928</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000249">
        <property type="protein sequence ID" value="RUS83306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZUQ3"/>
    <dbReference type="OrthoDB" id="6084619at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018686834" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="62"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS83306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="152" mass="16954" checksum="4A47A212AA6F1A37" modified="2019-04-10" version="1" fragment="single">MLSIVFVVVTLVTTVSCTGSADFSTNGQSRFSTDAPNTRGRYDFRFLHRNAESLHTLVREVGTVASLDCDVHPGPGPIPEIYWYKNGSPAHMWLNQGSSKMEESGWKLVIKQLTNADEGTYTCVLRKGQVNKQKQFSLKIKDKILKQADPYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZVR7</accession>
    <name>A0A3S0ZVR7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyrosine-protein kinase ephrin type A/B receptor-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_008089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000216">
        <property type="protein sequence ID" value="RUS84161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZVR7"/>
    <dbReference type="OrthoDB" id="6150569at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018743483" description="Tyrosine-protein kinase ephrin type A/B receptor-like domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS84161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="36194" checksum="45A9D1BB9F8CD8A2" modified="2019-04-10" version="1">MNFYGKYVIFLLLHAEAALVPVHLGNRTVIRHCINFPHFIPLNAVFSVRGSFQARLKCLDPNQDISLDTVELKGILICRPFSDINYDFYKILPPECKAHKIPAEIRITNRFIYNVRDCRSETIQSISALMTDRTQTYITNIDKPCGEGQRTCQSNFDYLCGISEEEHKKGYPYQLEVHNRVLTEYQPKQGLEFYRQLAQDIRNRVGCDESGQLLPDNRHKWENGLSHLVNVYVSSWVGTCSEHLYTRGTDLEVDGVLTCRGCPGKHYLYYKQCRLCEYGEYSKPPANKCMRCPHESLWTDTEKMEDLCFVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZVW7</accession>
    <name>A0A3S0ZVW7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Sodium-dependent multivitamin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_004201</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000094">
        <property type="protein sequence ID" value="RUS88035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZVW7"/>
    <dbReference type="STRING" id="188477.A0A3S0ZVW7"/>
    <dbReference type="OrthoDB" id="10366521at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF40">
        <property type="entry name" value="LD47995P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="241"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="513"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS88035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="576" mass="63014" checksum="35CB849E124BFDA3" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZZ54</accession>
    <name>A0A3S0ZZ54_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_013438</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000489">
        <property type="protein sequence ID" value="RUS78788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZZ54"/>
    <dbReference type="OrthoDB" id="10060331at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12493">
        <property type="entry name" value="CUE DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12493:SF0">
        <property type="entry name" value="CUE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="140"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS78788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="259" mass="28704" checksum="7252DCADACB9CFA0" modified="2019-04-10" version="1">MYCSREEDMLSNIDEIVLAYLVGVVELASQGDDGTDFEDVLDMMNAYLPGFEKIDRSDVIQWMFGLADKLASKEIVTDGVSLEQPVEPHTRAMPVTDNVPNGDCESQLHSMTQRRTFPLYDFSNSVAISGQQTTVKSLSHSCQIASDHQPSNLSKDKLEGTVSPQMKDKSTEDGQRIQRHPNSKPNNFHSDSFNEKKSRSKRKSRQLSCSSQESQEDSAVRVPSRPSPTQSPTLNVRSQANIVASLITVCAHVIIDRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A023</accession>
    <name>A0A3S1A023_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mothers against decapentaplegic homolog</fullName>
            <shortName evidence="8">MAD homolog</shortName>
            <shortName evidence="8">Mothers against DPP homolog</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">SMAD family member</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_001982</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the dwarfin/SMAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000036">
        <property type="protein sequence ID" value="RUS90293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A023"/>
    <dbReference type="STRING" id="188477.A0A3S1A023"/>
    <dbReference type="OrthoDB" id="5794312at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071144">
        <property type="term" value="C:heteromeric SMAD protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070411">
        <property type="term" value="F:I-SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060395">
        <property type="term" value="P:SMAD protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10490">
        <property type="entry name" value="MH1_SMAD_1_5_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.10:FF:000001">
        <property type="entry name" value="Mothers against decapentaplegic homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.520.10:FF:000001">
        <property type="entry name" value="Mothers against decapentaplegic homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.520.10">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013790">
        <property type="entry name" value="Dwarfin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003619">
        <property type="entry name" value="MAD_homology1_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013019">
        <property type="entry name" value="MAD_homology_MH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001132">
        <property type="entry name" value="SMAD_dom_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036578">
        <property type="entry name" value="SMAD_MH1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703:SF61">
        <property type="entry name" value="PROTEIN MOTHERS AGAINST DPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703">
        <property type="entry name" value="SMAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03165">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03166">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00523">
        <property type="entry name" value="DWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00524">
        <property type="entry name" value="DWB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56366">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51075">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51076">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MH1" evidence="10">
        <location>
            <begin position="14"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="MH2" evidence="11">
        <location>
            <begin position="217"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS90293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="410" mass="46741" checksum="05AED14468E190F8" modified="2019-04-10" version="1">MTTHLSSIFTFTSPAVKRLLGWKQGDEEEKWAEKAVDSLVKKLKKTKGALEDLEKALSCKDPSTKCVTIQRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLDTCCFPFSAKQKEVCINPYHYRRVESPVLPPVLVPRYSEYPTHGALPPFQQIHEPSMPHNITYPFQTQQQHSPQTPSSGPGSPFGLPGRFSLQNSSFLQPVTYQEPQYWCNIVYYELNNRVGEQFQASSHSIVVDGFTDPSRTDRFCLGLLSNVNRNSTIENVRRHITRGVHLYYVGGEVYAECLSESSIFVQSRNCNYSHSFHPTTVCKIPPTCSLKIFNNQEFAALLSQSVNHGYEAVYELSKMCIIRMSFVKGWGAEYHRQDVTSTPCWIELHLNGPLQWLDKVLTQMGSPMNAISSMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A0I0</accession>
    <name>A0A3S1A0I0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Radial spoke head 10 homolog B2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_012637</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000441">
        <property type="protein sequence ID" value="RUS79589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A0I0"/>
    <dbReference type="STRING" id="188477.A0A3S1A0I0"/>
    <dbReference type="OrthoDB" id="294378at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46613">
        <property type="entry name" value="RADIAL SPOKE HEAD 10 HOMOLOG B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46613:SF1">
        <property type="entry name" value="RADIAL SPOKE HEAD 10 HOMOLOG B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="636"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="875"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="641"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="696"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="738"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="752"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="880"/>
            <end position="901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS79589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="901" mass="101598" checksum="6D252CAA77C4E5C7" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A6H2</accession>
    <name>A0A3S1A6H2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_000402</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000005">
        <property type="protein sequence ID" value="RUS91831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A6H2"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS91831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="126" mass="14804" checksum="2BA294B84F404071" modified="2019-04-10" version="1">MVLNHTGWAHKNWFIMEKETYNANWSGEEGMPKIEKKLLVLKKNAKGPSKIKNIDNNIPPLPISGWKVRKKKKTTAEYAHQIKLRTTILVLHDHNNLLRYKRNNTIRHTIFINATIIYWSSKMCNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AVS6</accession>
    <name>A0A3S1AVS6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_023610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01002184">
        <property type="protein sequence ID" value="RUS68628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AVS6"/>
    <dbReference type="STRING" id="188477.A0A3S1AVS6"/>
    <dbReference type="OrthoDB" id="6230630at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20021">
        <property type="entry name" value="FH_FOXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000135">
        <property type="entry name" value="forkhead box protein G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047208">
        <property type="entry name" value="FOXG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46617">
        <property type="entry name" value="FORKHEAD BOX PROTEIN G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46617:SF3">
        <property type="entry name" value="FORKHEAD BOX PROTEIN G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="4">
        <location>
            <begin position="145"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="2">
        <location>
            <begin position="145"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="30"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="109"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS68628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="295" mass="33387" checksum="FED828067B243D45" modified="2019-04-10" version="1">MHNNLKKLNGFNPMPPDNKNCQCISDGTETLKLSPSSAARETRGTGNPGDTLLPRTNPYRGATPTGAPEAGPETESTVTSGSARLHSLEIQEAQGGRAEVKRRIGTVSKESHCVARTKDERNGGRKKEEEKSEEEKSEEEKKNEKPPFSYNALIMMAIRSSPEKRMTLSQIYEFITKNFPYYRDNKQGWQNSIRHNLSLNKCFIKVPRHYDDSGKGNYWMMDPSSDDVFIGSDTGKLRRRTHLSSHQRFCETWCHLPVPPASLQKPLQYGFGLPFQPMQHFAETPMTIFKTIAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AVW1</accession>
    <name>A0A3S1AVW1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_022540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001602">
        <property type="protein sequence ID" value="RUS69695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AVW1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS69695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="270" mass="30765" checksum="14D0178C8078D156" modified="2019-04-10" version="1">MVRTWIAKTLFKRKLKKRRFLDAYKGLVRFDINRHRCTDLNSQHQAKGLVRSAVYPFEMNKSTVSDEGITVFYDTFYCEMVEHSVPRVRSDLFFGVTANNAITLNKDAVMRYKVWEKNNIRVHGTGVSAGLERVLVEQNLTLTNTIAVAAFNHYLKENSFYQQGYVLPNNNTNVSILYVRQNSLSAQEMALYNNLFAVLAEQEELESGNLILSNEVIPVVETYIAEAKVIGLTEMDVPLPRDKAMYAMVTFDLKCAFNDSSFSGNKSDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B143</accession>
    <name>A0A3S1B143_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol N-acetylglucosaminyltransferase subunit P</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_019846</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PIGP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001073">
        <property type="protein sequence ID" value="RUS72386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B143"/>
    <dbReference type="STRING" id="188477.A0A3S1B143"/>
    <dbReference type="OrthoDB" id="690928at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017176">
        <property type="term" value="F:phosphatidylinositol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052263">
        <property type="entry name" value="GPI_Anchor_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013717">
        <property type="entry name" value="PIG-P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016542">
        <property type="entry name" value="PIG-P_GPI19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46346">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46346:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08510">
        <property type="entry name" value="PIG-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008765">
        <property type="entry name" value="PIG-P_GPI19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="PIG-P" evidence="9">
        <location>
            <begin position="12"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR008765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS72386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="129" mass="14646" checksum="A632C5556BFC65D1" modified="2019-04-10" version="1">MPQEHSPSPTPQRAIYGFALYIASFALFGLYIVWAYVPDQWLHWLGLTYWPQKYWAVALPVYFCVAIVLSYMVYFGLIFLKTASLSDMSTITDSQANYACDAALPVDAIPPLRDLHISDVNKRLYGSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B3E2</accession>
    <name>A0A3S1B3E2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_021238</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001289">
        <property type="protein sequence ID" value="RUS71003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B3E2"/>
    <dbReference type="OrthoDB" id="6131464at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS71003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="153" mass="18285" checksum="BEC0006B6137FADF" modified="2019-04-10" version="1">MSNCKNMTFESNQIRRSKSRWKRDGDGEKAQSELKQNEVEDNRTVTTNTSSDDFNSSYLREFYEERQAKKQLQFDAESAAICLVFISCLILFSLWYFRGFHNRNIKYREVTFHDSSHVLTVEEVLFRKRHYLPMFNQEDKMEEVFVHDCGNDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B4S2</accession>
    <name>A0A3S1B4S2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ZP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_016201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000691">
        <property type="protein sequence ID" value="RUS76045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B4S2"/>
    <dbReference type="OrthoDB" id="10672636at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018589085" description="ZP domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS76045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="461" mass="52947" checksum="7EABF9828396420A" modified="2019-04-10" version="1">MKHPPIVLVLCSVCLLNRVRVGESQESPNITVTVHNPPNVMYARHPIQGFCYGFPDADGTLEMRFHNKDFEGDDHMIGKYVFYKNLHSEVHRRLPMRMVLNISPDETVPGPENRVKRMVWFKICPTEALYKSYITCSSQDSKGVRMIRVRAAPSGPHKFVFKYEQGPSLPQVKTHYHFEPDIVIEGEMLRVSCTANVGTRGLLDFILKLPGKQDKHQWRVAYNLPYPTHLPEFKVEIFSKKSLTTTGPKIKATFSIEITRQLQGAILYCVSRDIFNNGSTFEKNSFNVISSKPLIVQEFPHKPHLYATNEIYMIFDKPRWILNGRCRTLTQFAQEILFVVKSGVWVHSTAVNMSSKTLNRSYKEKIPFTADTLVAFGFTGAGMPGEKWLEVRFYAFMWLESTDLRATCYVKDLKRCQRFTKLTATTIRKQAQSSRSPTVVRAASSRLLILWCLCMIPICMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B804</accession>
    <name>A0A3S1B804_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_010242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000309">
        <property type="protein sequence ID" value="RUS82015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B804"/>
    <dbReference type="OrthoDB" id="4066896at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS82015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="50" mass="5478" checksum="BD85A8F8F46C12F5" modified="2019-04-10" version="1" fragment="single">MVNAKSSANLVPDFLPIGDTPNNATSMPAVWNKDRMSSTDSPEREPGFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B887</accession>
    <name>A0A3S1B887_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_013878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000515">
        <property type="protein sequence ID" value="RUS78358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B887"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS78358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="237" mass="28157" checksum="F1F24E322EA6C300" modified="2019-04-10" version="1" fragment="single">VHGKIRKHEFHYSLYTTMCIKLKVNGKIRGGGGGRVHYSLYITICIKLKVNGKIRKHEFHHSLYITMCIKLKVNGKIRKHEFHHSLYITMCIKLKVNGKIRKHEFHHSLYITICIKLKVNGKIRKHEFHHSLYITICIKLKVNGKIRKHEFHHSLYITICIKLKVNGKIRKHEFHHSLYITMCIKLKVNGKIRKHRFHSLYITICIKLKVNGKIRKHEFHHSLYITICIKLKVNGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BAQ4</accession>
    <name>A0A3S1BAQ4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_016067</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000683">
        <property type="protein sequence ID" value="RUS76155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BAQ4"/>
    <dbReference type="STRING" id="188477.A0A3S1BAQ4"/>
    <dbReference type="OrthoDB" id="6102010at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF328">
        <property type="entry name" value="CADHERIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cadherin" evidence="6">
        <location>
            <begin position="57"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="6">
        <location>
            <begin position="166"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS76155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="275" mass="29656" checksum="E0315D04A42C369F" modified="2019-04-10" version="1" fragment="single">YFQIGQATGIITTTIDLRAATEANIVLTVSVTDGTHTIDDFDIFITIDNLNDRPQITNLPASVTIPETTVGGFQLITLTFTDVDTYVSQLIPTCTVVPAGDQYKFTYVSGTHKIQVATLSGATSPFDFETTSEYEITCVLNDGFQNSVGDVLTVNIENVNEAPQFDEVAYWCILTESSAGVSVCDLDASIVDPEGDTISSVTFQAGNNSQRFVYDRSLSTVTFGVDYDVDNNNMPTSVTLQLEAKDVNGASNHVPVYITINDANDNTCKFGATSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BCN8</accession>
    <name>A0A3S1BCN8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_011804</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000391">
        <property type="protein sequence ID" value="RUS80435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BCN8"/>
    <dbReference type="STRING" id="188477.A0A3S1BCN8"/>
    <dbReference type="OrthoDB" id="263283at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS80435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="122" mass="13611" checksum="5966C9B0CBD74632" modified="2019-04-10" version="1" fragment="single">ECHYLRERRDTCPVPCRAHTFCGDCVATAGCGWCSKQGANGEGFCMEGGISGPTHGAACRPGNITLLVPELLDFADRRQQRWHPKWAYESCPPENECKNQHHTCHNQTQSCKDYESGFSCEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BD29</accession>
    <name>A0A3S1BD29_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_014355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000545">
        <property type="protein sequence ID" value="RUS77881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BD29"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS77881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="118" mass="12435" checksum="424F24B3047000F6" modified="2019-04-10" version="1" fragment="single">MAAIAVTASAMMDKGRATPAELQTSSAMASKSRLQSIPCSCWDPLATSCLSLSISASVGRESELALMAHLTKVVKTGQILSLSLLASPPDMICPRNPCMSSLSFFRQFCISSAPHWAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BHW6</accession>
    <name>A0A3S1BHW6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_008170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000219">
        <property type="protein sequence ID" value="RUS84058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BHW6"/>
    <dbReference type="STRING" id="188477.A0A3S1BHW6"/>
    <dbReference type="OrthoDB" id="9997853at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902004">
        <property type="term" value="P:positive regulation of amyloid-beta formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026172">
        <property type="entry name" value="GSAP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13630">
        <property type="entry name" value="GAMMA-SECRETASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13630:SF1">
        <property type="entry name" value="GAMMA-SECRETASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS84058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="399" mass="44682" checksum="70848939ABF2A9D9" modified="2019-04-10" version="1" fragment="single">QWDVLHQRLHFIQNLRADNNGGAGNGSGVDGVQQKMSTIQFYSRGKYEGLIDVPINFPFPYIRTADKPHYGDIPLHPGIPELTLNVAVLTQTSGTFCLCYHKLITEPRAKTVPQIPTECQDIEYYISMVHHAKTLYGCVSNLPRHVALQKRLVFSWLGSYLVVMLPGYFVHLLNVSPTFEPCHHLLLHDYKMVPSIVADVSTSSTKHMSVKFDIGDEEESVLEEELKEQTPMDMSMGDSDPGQKAAGADRSDVEEQSPPSVETATLSQPLEVSASQQELGGSDSRPASEEVRQTDTSPGQRGHHSPSDCADQSESSTTVYPIFSKFCSAMKTLLPCQSFFRESGSTAQHLYDYRSGCLMKLVLNVDLMLDSFKKSYWQTRLAILHYLILHHKDPYAIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BI98</accession>
    <name>A0A3S1BI98_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_010828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000339">
        <property type="protein sequence ID" value="RUS81390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BI98"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS81390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="264" mass="30503" checksum="47E81E7170744B57" modified="2019-04-10" version="1">MVRGSAPSGSRQCLDSRVSSPEPGCWVPLGVYASMENSFDKSKLFYFLSYSPSSTTWVPGGLCTQIIKRGELVQVAEHWSPDLKLSFFDACFRGDGGRDSSRVEHWLPTLEVRGSSLVDFAHYWLGRCQLNVMDWDRIHGILAQHIKFSDDGYGYISAVSRELAAFSVLTSQTCEVWWSSHAPRAKTETERWRKKKREGGWVEKESEREISGGEGEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BIQ5</accession>
    <name>A0A3S1BIQ5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_010519</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000323">
        <property type="protein sequence ID" value="RUS81712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BIQ5"/>
    <dbReference type="STRING" id="188477.A0A3S1BIQ5"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS81712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="151" mass="15999" checksum="D588E62923A7CDAC" modified="2019-04-10" version="1" fragment="single">KTSRSCCITGTKTSRSCCITGTKTSRSCCITGTKTSRSCCITGTKTSRSCCITGTKTSRSCCITGTKTSRSCCITGTKTSRSCCITGTKTSRSCCITGTKTSRSCCITGTKTSRSCCITVAQTSRRCCITVTKTSRRCCITVTKTSRRCCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BKV4</accession>
    <name>A0A3S1BKV4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_009146</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000258">
        <property type="protein sequence ID" value="RUS83114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BKV4"/>
    <dbReference type="STRING" id="188477.A0A3S1BKV4"/>
    <dbReference type="OrthoDB" id="9993688at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23800">
        <property type="entry name" value="UBCc_UBE2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000021">
        <property type="entry name" value="Putative ubiquitin-conjugating enzyme e2 k"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="4"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="161"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS83114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="199" mass="22209" checksum="2FE1DC4F00EDF829" modified="2019-04-10" version="1">MANIAEQRIKREFREVVKSDEVAACNIKVELVNDNFTELRGEIGGPPDTAYEGGNFKLEINIPETYPFNPPQVKFVTKIWHPNISSVTGAICLDILKDQWAAAMTLRTVLLSLQALLAAAEPDDPQDAVVAQQYKDNNAIFQRTARHWTTAYAGGPNIDAELEEKVTSMKNMGFDEHKARVALSTKDWDVTRAAEYLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BL91</accession>
    <name>A0A3S1BL91_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_001281</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000021">
        <property type="protein sequence ID" value="RUS90977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BL91"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018687528" description="Chitin-binding type-2 domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="3">
        <location>
            <begin position="77"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS90977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="261" mass="29092" checksum="1EAE5EB4844D270C" modified="2019-04-10" version="1">MNLLIVSLLVLITAPDLCNADSDDHKYDEHYESDSGENYGDSSHDYNGHSESLTSDYLDAYSAAAQSNGLVRCTPGCAHGQPQHVVTCPGNLHFNTHLNVCDWPSNVDCSSGRSSSYTEYDNSHSEDHTDYHDNENYGHYNEHDDTGDGYSESYYSHSNEDDDDNDHESYTSDDDHDDDDDEEGDYDHNWDHDGYHGDYGHGSYGPGYLGHHPLSLTGYMPVQWHPHPAFGLSGSYHPNGEPLFRTLSTYGELQSHSLSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BQK2</accession>
    <name>A0A3S1BQK2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_019756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001062">
        <property type="protein sequence ID" value="RUS72474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BQK2"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS72474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="99" mass="11229" checksum="0058AA00CC386CED" modified="2019-04-10" version="1">MYCKCTTRSERSQVFTTASVHTSVHHKCSHQCSPRMFTLVFMTSVHHKCSPMFTNLCTCTSHFGLSWFLIRQCIDKLTLGDDLVVNLIFIGSGIILLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BTH3</accession>
    <name>A0A3S1BTH3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_001252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000021">
        <property type="protein sequence ID" value="RUS90948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BTH3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS90948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="207" mass="23437" checksum="7D3C024A9ADA64FE" modified="2019-04-10" version="1">MKISRGVNDVVSPSGEDNSLHPSAWITRKARPSARLSWASRDYWYRPRARSRALNSPVWCKGVLGGRSGPGVEHRPPTQEVRKSSSGDFVPYELGSRQAWTVLRDCQAGSRHRHRPPFDLADQAGLALFLLIVDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDKYNDDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BU57</accession>
    <name>A0A3S1BU57_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_003498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000074">
        <property type="protein sequence ID" value="RUS88781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BU57"/>
    <dbReference type="OrthoDB" id="6176983at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018661869" evidence="1">
        <location>
            <begin position="19"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS88781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="121" mass="12871" checksum="2BC22477DC4F45A4" modified="2019-04-10" version="1" fragment="single">MGNLYLLVAAALVSVTWATPCTDICLGTCEIAAQTHRIFLPMFEAFVQPNLDFCRSVCTVTCNCVDTCQGACGAQLATCRDVPSGGFFHFFQCQVEFTACGTVCSTQCSMSATAGVLDRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BUX1</accession>
    <name>A0A3S1BUX1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_016776</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000741">
        <property type="protein sequence ID" value="RUS75453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BUX1"/>
    <dbReference type="STRING" id="188477.A0A3S1BUX1"/>
    <dbReference type="OrthoDB" id="8872930at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.140.2220:FF:000001">
        <property type="entry name" value="CBFA2/RUNX1 translocation partner 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1110:FF:000001">
        <property type="entry name" value="RUNX1 translocation partner 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1110">
        <property type="entry name" value="TAFH/NHR1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013289">
        <property type="entry name" value="CBFA2T1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014896">
        <property type="entry name" value="NHR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037249">
        <property type="entry name" value="TAFH/NHR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003894">
        <property type="entry name" value="TAFH_NHR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10379">
        <property type="entry name" value="MTG8 ETO EIGHT TWENTY ONE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10379:SF14">
        <property type="entry name" value="NERVY, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08788">
        <property type="entry name" value="NHR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07531">
        <property type="entry name" value="TAFH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01875">
        <property type="entry name" value="ETOFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00549">
        <property type="entry name" value="TAFH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158553">
        <property type="entry name" value="TAFH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51119">
        <property type="entry name" value="TAFH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TAFH" evidence="12">
        <location>
            <begin position="99"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="11">
        <location>
            <begin position="473"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="23"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="242"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="561"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="276"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="561"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="596"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="627"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS75453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="676" mass="73073" checksum="A43D618828781F84" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BW42</accession>
    <name>A0A3S1BW42_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_002057</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000038">
        <property type="protein sequence ID" value="RUS90178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BW42"/>
    <dbReference type="OrthoDB" id="6271941at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050801">
        <property type="entry name" value="Ca-Dep_Lectins_ImmuneDev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801:SF63">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801">
        <property type="entry name" value="LITHOSTATHINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018642390" description="C-type lectin domain-containing protein" evidence="2">
        <location>
            <begin position="31"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="151"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS90178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="273" mass="29809" checksum="B2147F7502C3FF51" modified="2019-04-10" version="1">MRDAMYKLHIFQKFGSVILLVLVTLDKGRATNGTLSGCQSSAAQVSTTLVFTPTTLTSVSPFVPHRLMSPGWSGIPTVLECAHLTVRGYPQARGYLYHKVTGSCTPLLWLESPTKPSAREVTAEEGTLYLSGICGNGFTLHEYGLVGDLACLRDSVSTATYKVATRTCASWGGHLASVKTSAKLDLIANISSGESRWIGLDDIDTEGQHIWQSDGSMLTSAEQEAVFGSFEPNNRNGAEDCVEFRRKTQKLNDLPCRYEIRYICEITLPSLDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BXK8</accession>
    <name>A0A3S1BXK8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_014749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000576">
        <property type="protein sequence ID" value="RUS77502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BXK8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018522713" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS77502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="21140" checksum="9398B797E175635B" modified="2019-04-10" version="1" fragment="single">MKLVLAICMILGTVGRFCQVDAVACNEDKSACLKTDFTTETCDKSKKCKCLAGYEPTLEGCIKKPNKPTVDLDGIHNDEALEGSNVNLTCNGEAASEYKWYKDRELDAKQTRPNAIFRMDKGNIIIECALVSRVESDKSGALTIKYLKKDSTATPKINFSPNKVAENKKYTATCTGYPWGFDANKNVIFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C355</accession>
    <name>A0A3S1C355_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane protein 45B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_010632</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM45 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000327">
        <property type="protein sequence ID" value="RUS81619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C355"/>
    <dbReference type="OrthoDB" id="551896at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006904">
        <property type="entry name" value="DUF716"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042127">
        <property type="entry name" value="TMEM45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16007">
        <property type="entry name" value="EPIDIDYMAL MEMBRANE PROTEIN E9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16007:SF15">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 45B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04819">
        <property type="entry name" value="DUF716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="264"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS81619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="33634" checksum="7016C8772AF49935" modified="2019-04-10" version="1">MGDFKGHAMPGSCLVAMGMWWAFWAMRRYFICRRSGTRFVSTASYNMGWSCGRMGAIPVESFMKIALSAFGMFAEITLNLPHLAMGIVQHATMYFFFMTSGVVDLCIHYGVPLPHGTDYAALALALTVEGLLFVNHLHGRSELDVQLHMLLAYVVFSTVLVLLLEIKFQRSALLSLGRAYLTILQGTWFWAVGVILYMHGKPNTVWTGDKPMEVMQATIYFTWHASVIFILMLVTSLIMSRIYRGEAVPYRNGSDLAMSRLGNGNGKGGEDYQPLTKEFHDDESDIEFEQPIDKSHPTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1CCT2</accession>
    <name>A0A3S1CCT2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_003069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000063">
        <property type="protein sequence ID" value="RUS89190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1CCT2"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="402"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="683"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="430"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS89190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="900" mass="102484" checksum="8E9DEE67EF309A24" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1CFM0</accession>
    <name>A0A3S1CFM0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nose resistant-to-fluoxetine protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_000829</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000012">
        <property type="protein sequence ID" value="RUS91399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1CFM0"/>
    <dbReference type="OrthoDB" id="207378at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00703">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="423"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="686"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="731"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="801"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="823"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="864"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="893"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="941"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1006"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="3">
        <location>
            <begin position="291"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS91399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1042" mass="114462" checksum="4834E77849581488" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H6F0</accession>
    <name>A0A3S1H6F0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PKD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_019060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000969">
        <property type="protein sequence ID" value="RUS73168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H6F0"/>
    <dbReference type="OrthoDB" id="10050421at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS73168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="16548" checksum="675E31E411C4ED70" modified="2019-04-10" version="1" fragment="single">PSAFVITYVGTSLPEAGSVQITIDYGDGTTADSGPHAFPVGSTGASTTIQHVYASDNTFTATVTVFSDCCSVLNNVSVGVYKGITNLQASIYYLADVPPGAQTYGLLGNSQVYPTNKALHFVMTNQDNVFATAYEVTVNAGGSVILTCVKTSPTFTLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H9R4</accession>
    <name>A0A3S1H9R4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_017228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000778">
        <property type="protein sequence ID" value="RUS75005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H9R4"/>
    <dbReference type="STRING" id="188477.A0A3S1H9R4"/>
    <dbReference type="OrthoDB" id="160374at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS75005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="686" mass="76579" checksum="B42B360F67470630" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HAL1</accession>
    <name>A0A3S1HAL1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_016768</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000740">
        <property type="protein sequence ID" value="RUS75470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HAL1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS75470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="329" mass="35444" checksum="1774A93CACE461B6" modified="2019-04-10" version="1">MHWNTSAESPYYRLRFHYRFSTPYRNNSNVTACCLSSAPVSGKSHQSHHSFSFLQALLGTAPVSGKSHQYHHSFSFLQALLGTAPVSGKSHQSHHSFSFLQALLGTAPVSGKSHQSHHSFSFLQALLGTAPVSGKSHQSHHSFSFLQALLGTAPVSGKSHQSHHSFSFLQALLGTAPVSGKSHQSHHSFSFLQALLGTAPVSGKSHQSHHSFSFLQALLGTAPVSGKSHQSHHSFSFLQALLGTAPVSGKSHQSHHSFSFLQALLGTAPVSGKSHQSHHSFSFLQALLGTAPVSGKSHQSHHSFSFLQALLGTAPVRQTDRQTDRQTQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HBA9</accession>
    <name>A0A3S1HBA9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_016418</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000709">
        <property type="protein sequence ID" value="RUS75826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HBA9"/>
    <dbReference type="STRING" id="188477.A0A3S1HBA9"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF176">
        <property type="entry name" value="ARRESTIN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="3">
        <location>
            <begin position="140"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS75826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="27919" checksum="B8EFD6236592A198" modified="2019-04-10" version="1" fragment="single">KLAKPTWIHSINIKFTGRAKSKWDVSNGDSSKQYKATEVYIDSEHHLYRCGDENDVQPAGLHMYPFDFTLPSDVPSSFEGRRGFVRYLCVVTLDRSWKGVLQIEQDLTVIRHLDLNQVPHAGLPQTLEREEVYEGCCCDSGDVTAKLQMPKCGYVPGEPLLYNLAITNEATSSICGFGMSLIQTVRYTGYSDSLFSSGNPKYHDKVNSWTLRQADEEIPPGKTATYSSHCVIPAVAPSLLEGCNIIDINY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HEH2</accession>
    <name>A0A3S1HEH2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_014565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000561">
        <property type="protein sequence ID" value="RUS77668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HEH2"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS77668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="156" mass="15905" checksum="49A7CACA3D041BCB" modified="2019-04-10" version="1" fragment="single">GKFFVSHWAAKRNAINKRTSGQRRPNQPLYLHLETHLQKSSNSLSTMAQVVSYVLCVFLLATIASVNGFSKYYGGGFGKYGGFGGYGGYGGYGGLGGFGHGYGYGGYGLGGFGGYGMGGLGGYGLGGFGGGFGGGYGMGGYGLGGGLGMFGRGMYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HI55</accession>
    <name>A0A3S1HI55_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_012360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000423">
        <property type="protein sequence ID" value="RUS79882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HI55"/>
    <dbReference type="STRING" id="188477.A0A3S1HI55"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045095">
        <property type="term" value="C:keratin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002494">
        <property type="entry name" value="KAP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13885">
        <property type="entry name" value="Keratin_B2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0416">Keratin</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS79882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="106" mass="12959" checksum="EA440754D26C105F" modified="2019-04-10" version="1" fragment="single">ETTCRPTRCRPTICRPTRCRPTRRRPTRRRPTRCRLTRCRPTRCRPTRCRPTRCRPTTCRPTTCRPTRCRPTRCRPTICRPTRCRPTRCRPTRRRPTRCRPTRCRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HID4</accession>
    <name>A0A3S1HID4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">small monomeric GTPase</fullName>
            <ecNumber evidence="2">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_012216</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="2"/>
    <dbReference type="EMBL" id="RQTK01000414">
        <property type="protein sequence ID" value="RUS80046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HID4"/>
    <dbReference type="STRING" id="188477.A0A3S1HID4"/>
    <dbReference type="OrthoDB" id="18798at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051065">
        <property type="entry name" value="Ras-related_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45704">
        <property type="entry name" value="RAS-LIKE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="197"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS80046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="275" mass="30751" checksum="53AB568929D561B1" modified="2019-04-10" version="1" fragment="single">AFSVRFITRRYIGEYDPLLERIYTCQRTILDSAVDFELWDTAGINENSKLKEHVRWADAIILMYDVTDRCSFNECSRLKFLVNAHSRSSRRRKAGSDPSCEPVWGSTPVALVGNKKDRDQDRMVSAQEGAERSAQLSCVSFQEVSVQEDVDEVTDVLEELYQTYRKLRKSRPSLVVSTLTASKSSLLFFGDSGRLNGGGSSSDEDSGNATNNGSNNSKHPDRDSTDGGISKSGNAEKTRSLARRVTLGNTAVEAPNEDWIIKARSRRREAFYTIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HX35</accession>
    <name>A0A3S1HX35_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_004310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000097">
        <property type="protein sequence ID" value="RUS87894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HX35"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS87894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="252" mass="27832" checksum="6128EAE369C02BDE" modified="2019-04-10" version="1">MRTTQAQCQISQMSLQEGKAEYVKSESCHRCDQLPSIELQNQALNSHDSLQTILRPVAIVSGNGNAMSPSIANKQGDLDFISREQSTEVTLSGRIEETKALDFHLTLGQHDGNDSYKKQLTDIQNCGAVKGKEPNSDLCHKMAQAAISESIPLDKSEDYEKDKSGSEIPAVNLAETSLSDRVQNLRLQEVEDSANTKIADAVYARKVQKTIVSNDGEIPDFLHIKVKSEKIVEKLPGNEEFGTCVNELRKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1I3W7</accession>
    <name>A0A3S1I3W7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U3 small nucleolar ribonucleoprotein protein IMP3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">U3 small nucleolar ribonucleoprotein protein imp3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_000557</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000007">
        <property type="protein sequence ID" value="RUS91731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1I3W7"/>
    <dbReference type="STRING" id="188477.A0A3S1I3W7"/>
    <dbReference type="OrthoDB" id="10248812at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000006">
        <property type="entry name" value="U3 small nucleolar ribonucleoprotein IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="11">
        <location>
            <begin position="4"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="10">
        <location>
            <begin position="108"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00072223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS91731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="182" mass="21695" checksum="BF277D5A88C85864" modified="2019-04-10" version="1">MVRKLKFHEKKLLKKVDFLSWEVDNNLHELKIMKRFHIQRREDYTLYNKLSRQIRLVSQAIKEMDQKHPRRVEFTEQLLEKLHSMGLIPTKRSLSLADRVSASSFCRRRLPVLMVRNHMSETLKAATTFIEQGHVRIGPHVVDDPAYLVTRGMEDFVSWKDTSKIKKQVQEYNDMRDDFDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SI26</accession>
    <name>A0A433SI26_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ketoreductase (KR) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_023786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01002801">
        <property type="protein sequence ID" value="RUS68452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SI26"/>
    <dbReference type="STRING" id="188477.A0A433SI26"/>
    <dbReference type="OrthoDB" id="6046936at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975:SF2">
        <property type="entry name" value="EG:BACR7A4.14 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975">
        <property type="entry name" value="ZGC:101858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS68452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="134" mass="14751" checksum="16B1014C2346780E" modified="2019-05-08" version="1" fragment="single">PLRLTQALYYSGASAGIGVAIAQEFAKQGCHLMLCGRDKTRLDQVVTQCQQTAPSDVKIYTTVGDVTSQPVQESIINNTVSQLGGIDVLVSSYFSFLTQSHLDRSAHPTQLQPKRREITPQEYPTLLVLKNCKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SJP7</accession>
    <name>A0A433SJP7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_022913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001727">
        <property type="protein sequence ID" value="RUS69327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SJP7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS69327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="141" mass="16717" checksum="27E6FF8DB99D6C05" modified="2019-05-08" version="1">MGQPEVNMSIWREEKGRERKLLTTKQGTRNLRYNPLFTKGMQYSCSLQGSALQCLGQNEPPRRIATAKATEHVDASEKREIDWFLVLYSAEIFAVIYIILWTISNFCQHMRLLMWGQRMQLERKERYLRECTIVFPRARKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SKT4</accession>
    <name>A0A433SKT4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_022501</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001589">
        <property type="protein sequence ID" value="RUS69734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SKT4"/>
    <dbReference type="STRING" id="188477.A0A433SKT4"/>
    <dbReference type="OrthoDB" id="426654at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45942">
        <property type="entry name" value="PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="144"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS69734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="241" mass="27617" checksum="3FC9EF64C571FB56" modified="2019-05-08" version="1">MATYDEIRKKTSALAAKLSSATGIAKSTVMNIIMYAKCLQCPTKPDVIEDLVFLAQMGLRFGITSRYHLQLMLEATRPPRSQYIHLEDYVKVICIFLCSDLDVRINFVFEVYNFTNSGFIQIQDITQLLKNSIHTMSDEDANEQLKEMIEMLVSVIDSNADNLLSLEEFRAFVKKNILCLELFGKILPDPAILKSFRFIMENKAPSKIRDYFQHERTRCLGEPETKEKDNALYPGVVLDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SLJ1</accession>
    <name>A0A433SLJ1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_022203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001508">
        <property type="protein sequence ID" value="RUS70030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SLJ1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS70030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="209" mass="23111" checksum="42A32573907582E2" modified="2019-05-08" version="1">MGYEVYTDSGHMGYELYTDSGHMGYEVYTDSGHMGHEVYTDSGHMGYEVYTDSGHMGYEVYTDSGHMGYEVYAVQSTHRFQNGVFASALESRPTPNTQAGEREALALHLHALQTRGVCKPFVTSVGSFGSPGAVPCQQPSRSTQLIYLTVKEPSPPLEQFAWDKLIQPPHGSTRALVGLMCADTSPTPRQHLANTSNFCILIVTRWHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SPB6</accession>
    <name>A0A433SPB6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_021152</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001275">
        <property type="protein sequence ID" value="RUS71091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SPB6"/>
    <dbReference type="STRING" id="188477.A0A433SPB6"/>
    <dbReference type="OrthoDB" id="6600758at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23798">
        <property type="entry name" value="UBCc_UBE2I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000013">
        <property type="entry name" value="SUMO-conjugating enzyme UBC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="10">
        <location>
            <begin position="4"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="8">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS71091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="160" mass="18396" checksum="6B00A49DAC28F3E9" modified="2019-05-08" version="1">MSGIALGRLAEERKAWRKDHPFGFVAKPTKNPDNTLNLLHWECKIPGKKGTPWEGGLYVLKMLFKDDYPSSPPKCKFEPPLFHPNVYPSGTVCLSLLDEEKDWRPAVTIKQILLGIQELLNEPNIKDPAQAEAYTIYCQNRAEYERRVREQGSRFRDPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SPH2</accession>
    <name>A0A433SPH2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_021116</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001269">
        <property type="protein sequence ID" value="RUS71125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SPH2"/>
    <dbReference type="STRING" id="188477.A0A433SPH2"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF67">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="55"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS71125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="211" mass="24130" checksum="06F580B938E98A13" modified="2019-05-08" version="1">MSIGSLRDQVIYPDSPEDMRRKGFTDEDLMYILEIVHLAHIVHREGGWDTALDWKDVLSGGEKQRMGMARTFYHKPKFALLDECTSAVSIDVESKIYLGLKDAGITLMTITHRPTLWKFHTHLLQFDGEGGWRMEELDTNTRLTLNEEKNRLENQLAGMPGMQERLRELCSLLGEDSVLLSPEVAAVQDEEEAECELPGEERNDSSFEMEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SU15</accession>
    <name>A0A433SU15_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heparan-alpha-glucosaminide N-acetyltransferase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_019506</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001025">
        <property type="protein sequence ID" value="RUS72739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SU15"/>
    <dbReference type="STRING" id="188477.A0A433SU15"/>
    <dbReference type="OrthoDB" id="2149840at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012429">
        <property type="entry name" value="HGSNAT_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31061">
        <property type="entry name" value="LD22376P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31061:SF24">
        <property type="entry name" value="LD22376P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07786">
        <property type="entry name" value="HGSNAT_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Heparan-alpha-glucosaminide N-acetyltransferase catalytic" evidence="3">
        <location>
            <begin position="32"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS72739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="376" mass="42239" checksum="34E9C8FA13CA1339" modified="2019-05-08" version="1">MMADLGSPTNINPVDDGNPSSESIAPPPTKERLKSLDTFRGISIVIMIFVNYGGGNYWFFKHSRWNGLTVADLVFPWFIFIMGTAMALSFQSQIRRNVPRWKMFTKVVRRSVTLFLLGLLINSFGVRNGVEFDTFRIPGVLQRFAGTYLVTATVYLFLTPQGYLGPGGLEQGAKYYNCVGGASGYIDRTFFGSNHIYASPTSQEIYRSTLPYDPEGLLGTLNSCVLCFLGLQAGKILFVYTDWVQRTRRFFIWSLILGGLGILLCEGSLNDGWIPINKNLWSLSYILVMSAMSFFLLMICYILIDVYKLWSGAPFSFAGMNAIALYCGHEFFSGRAPVYFAVPETHGALLAINLWGTAFWVLVSIYFYYNNIFLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SVJ1</accession>
    <name>A0A433SVJ1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Laminin G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_018934</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000952">
        <property type="protein sequence ID" value="RUS73305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SVJ1"/>
    <dbReference type="STRING" id="188477.A0A433SVJ1"/>
    <dbReference type="OrthoDB" id="6092475at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019454440" description="Laminin G domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="3">
        <location>
            <begin position="23"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS73305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="217" mass="23859" checksum="9AC11FF6B96F5778" modified="2019-05-08" version="1">MDVSFIGLLLTLVVELASANDNDPCFTFHGNGFLRFHLDKFDNSNSAHYSLKFRTQSAHGLLLYSEGVHGDDEALYIRNGMLVYHLFNSSPSGVEGSFGGRFLGEVAVNTDDMIEVHTYRSFSVTDEVQRTTREQTGLVYTVGGNTYSHIDYRPRSGISLNNDVYVGGYKESLSDTVGNFTGQISGIREEKNAALFRSFSLNAGGKVTSNCLTINPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SWD8</accession>
    <name>A0A433SWD8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_018670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000922">
        <property type="protein sequence ID" value="RUS73579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SWD8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS73579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="266" mass="28261" checksum="C8659A017BE2E606" modified="2019-05-08" version="1">MSVVTSPHLKSLVKNVSAVTSPHLKLRGGLVLCPDCPSGRARGATDPALALRPLVLAPWSALRPVRDCTVHSEARGGQWAAGHPPGAVRREGHPVTVTVTVTVTVTVTVTVTVQGQVSPVALTRHDQSHIHIHSHSHSQSQSQSQSQSQSQSQPQSQYTYTATVTYTVTVTVTVTYTVTVTATVKFTVTFTDTVTVTVTYTVKVTVTATVTVTITDKVTATATVTVTDKVTDTATVTVTVTVFTQSHTHTQPQSQSQTKSQTQPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SXA7</accession>
    <name>A0A433SXA7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_018291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000882">
        <property type="protein sequence ID" value="RUS73953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SXA7"/>
    <dbReference type="OrthoDB" id="10058719at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053819">
        <property type="entry name" value="TEADIR3_omega_loop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15238">
        <property type="entry name" value="TEADIR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS73953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="192" mass="20074" checksum="6619D08F6AFE66BB" modified="2019-05-08" version="1" fragment="single">APKSDTAASSTLQLSPSEASSEGDVHANSPTSSSSNSCFAYELDHDYENVASPCSSTASGPTYVRQPGFRHHAHEVTIPAGGSIAAGAPSSFFSSSPSSSSAANASLFSASLSPANHTPFSPCCLVEPLPMKLRALPQSFWQQPNVAHQVSPATLFPILPPLPNKDTEETLMGESRIIIVPLYGQTETLMGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SYU4</accession>
    <name>A0A433SYU4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_017753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000827">
        <property type="protein sequence ID" value="RUS74478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SYU4"/>
    <dbReference type="OrthoDB" id="10419773at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019562140" description="C-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS74478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="24295" checksum="7BBE389AC58277A1" modified="2019-05-08" version="1">MHAQSTLRLVCFQLLVLGYAVQGVLFDFHVIDTLQNAQDGSRVCKALMYDGFAVLNSPESYNHALRISQALRKKKRIGMYVGLTYNSETDVIVWSDGTLPASDSPWAGKIGNPKFGFIRSAGALNLDNGFERRMALCGNHSKLPTETRGVTFLDQRPADVTSVLSVVKLGSYLECVLVCGQDHRCRTAEFQSGRRACTLLGPGGNSGLVASAGSRTFVREAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SZS1</accession>
    <name>A0A433SZS1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Oxaloacetate tautomerase FAHD1, mitochondrial</fullName>
            <ecNumber evidence="5">3.7.1.5</ecNumber>
            <ecNumber evidence="2">4.1.1.112</ecNumber>
            <ecNumber evidence="9">5.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Acylpyruvase FAHD1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Fumarylacetoacetate hydrolase domain-containing protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Oxaloacetate decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EGW08_017422</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">EC2010</strain>
            <tissue evidence="16">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:26168"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16854"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19009"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57278"/>
            <dbReference type="EC" id="3.7.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>acetylpyruvate + H2O = acetate + pyruvate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16097"/>
            <dbReference type="ChEBI" id="CHEBI:15360"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>oxaloacetate + H(+) = pyruvate + CO2</text>
            <dbReference type="Rhea" id="RHEA:15641"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="EC" id="4.1.1.112"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>oxaloacetate = enol-oxaloacetate</text>
            <dbReference type="Rhea" id="RHEA:16021"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17479"/>
            <dbReference type="EC" id="5.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:16023"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.5" evidence="5"/>
    <dbReference type="EC" id="4.1.1.112" evidence="2"/>
    <dbReference type="EC" id="5.3.2.2" evidence="9"/>
    <dbReference type="EMBL" id="RQTK01000796">
        <property type="protein sequence ID" value="RUS74813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SZS1"/>
    <dbReference type="STRING" id="188477.A0A433SZS1"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047621">
        <property type="term" value="F:acylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000003">
        <property type="entry name" value="Fumarylacetoacetate hydrolase domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007967">
        <property type="entry name" value="PRK10691.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="15">
        <location>
            <begin position="13"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RUS74813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="214" mass="23281" checksum="49CDEAC50991DAD7" modified="2019-05-08" version="1">MSKFAQFKEIGKKIVCVGRNYREHAAELNNPVPSKPMLFLKPTSAYISEGDAIKIPKGCTDLNHEVELGVVIGATAKDVSITEAMNYVAGYALGLDMTARDWQAVAKSKGHPWSVAKGFDTSCPISKFVEKEKIPDPNNLDLWLKVNGEMRQSGNTKDMIFPVEHLISFASQCFTLEPGDLILTGTPAGVSKLNSGDVIQAGLANIIQVQFLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T1Y2</accession>
    <name>A0A433T1Y2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_016630</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000725">
        <property type="protein sequence ID" value="RUS75604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T1Y2"/>
    <dbReference type="STRING" id="188477.A0A433T1Y2"/>
    <dbReference type="OrthoDB" id="5965749at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22750">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="8">
        <location>
            <begin position="61"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS75604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="343" mass="38689" checksum="8BAECA9609B4ABF8" modified="2019-05-08" version="1">MDLSNIYTTEPSSTGLFSNVTYEDFDKEESGPINSEGKRKKWIYVAFTLACLVVAIFVLTCNIIFVAACWRTRSLRTLSTLFVISLAGSDMFQAVGMILQALFYANIWIDAVLWTASLCPWIKVVFLTCVPISMMSVAFVAIDRYIYIIFPYRYPHVMTARRSTTAIALVWVTWVAFGFSTLYHKHEGPSCMVTMAVQAAYIWTRLVVFVISAAVSGFCHVSIQLVAVKQLRKVHSCANTARISNRNASATTPQGITITSLRLVKTFFLIYVSHLVCWTPALVTPIFRLQAKGVTNLFYILAEFSAAINVIVYIYSNAQFRRAIVRLIRCLPKFSSFDQKAWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T5L2</accession>
    <name>A0A433T5L2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent DNA helicase PIF1</fullName>
            <ecNumber evidence="13">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">DNA 5'-3' helicase PIF1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">DNA repair and recombination helicase PIF1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PIF1</name>
        <name evidence="18" type="ORF">EGW08_015348</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">EC2010</strain>
            <tissue evidence="18">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer. Interacts with telomerase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the helicase family. PIF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="13"/>
    <dbReference type="EMBL" id="RQTK01000626">
        <property type="protein sequence ID" value="RUS76879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T5L2"/>
    <dbReference type="STRING" id="188477.A0A433T5L2"/>
    <dbReference type="OrthoDB" id="272985at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18037">
        <property type="entry name" value="DEXSc_Pif1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000805">
        <property type="entry name" value="ATP-dependent DNA helicase PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003367">
        <property type="entry name" value="ATP-dependent DNA helicase PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03176">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057437">
        <property type="entry name" value="PIF1/LRR1_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048293">
        <property type="entry name" value="PIF1_RRM3_pfh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF7">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25344">
        <property type="entry name" value="PH_LRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 13" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIF1/LRR1 pleckstrin homology" evidence="17">
        <location>
            <begin position="5"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="15">
        <location>
            <begin position="229"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="16">
        <location>
            <begin position="483"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="DNA-binding region" evidence="13">
        <location>
            <begin position="600"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="140"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="650"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="251"/>
            <end position="258"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00065873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF25344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RUS76879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="670" mass="74254" checksum="91752F7318AA4B2C" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T7L0</accession>
    <name>A0A433T7L0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_014657</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000570">
        <property type="protein sequence ID" value="RUS77581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T7L0"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS77581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="105" mass="11280" checksum="4A2AC30997A789B4" modified="2019-05-08" version="1" fragment="single">HVLGVDVGVALQQELHDGQVALLGRDVQGRAVNLGACVSTDPCSEQDLGCVLVPKLGRKVQRRYLTTSDPHPVCGERRPVRHKRPNRVGLASLGGLQQALAQVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T7V5</accession>
    <name>A0A433T7V5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_014546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000560">
        <property type="protein sequence ID" value="RUS77681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T7V5"/>
    <dbReference type="OrthoDB" id="10677613at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="489"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS77681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="694" mass="75294" checksum="89C30A2192B5BA7F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T9U5</accession>
    <name>A0A433T9U5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_013890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000516">
        <property type="protein sequence ID" value="RUS78339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T9U5"/>
    <dbReference type="OrthoDB" id="10291533at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS78339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="165" mass="19336" checksum="E15111F4E9EE8AB8" modified="2019-05-08" version="1">MVRYVGIDKGRGDPRKTLGHDRGPYYIQGFSSPQRLKSWAHEVLQVLDKPNVAVCIFIFGVVIIVVASKQLKATFDILEYYWGGGRPQDGVIGHFMVILVFLFVWLDTVILQWIKGLVIHFHHFLRRRYYQLLEVLERIQEDDELKAVQRRKMLNKKRGTVKRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TAC4</accession>
    <name>A0A433TAC4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Temptin Cys/Cys disulfide domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_013699</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000504">
        <property type="protein sequence ID" value="RUS78521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TAC4"/>
    <dbReference type="OrthoDB" id="129121at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057626">
        <property type="entry name" value="S-S_Temptin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055313">
        <property type="entry name" value="Temptin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34737">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34737:SF2">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24784">
        <property type="entry name" value="Temptin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Temptin Cys/Cys disulfide" evidence="2">
        <location>
            <begin position="82"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS78521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="154" mass="16935" checksum="79A5D368791C88E0" modified="2019-05-08" version="1">MPRSSSNYRPYDKGRHSQIEDDSNLMMMMMMTMHPTAPSLLLSTAILLTVLAPLAVDSYPTNRDRIPNGYNVPDPCRPGRTAQWTSALCNADSDGDGIANGVELGDPSCTWTQGQTPQSTSGITHPGINNDNPGCLVPPWLWKLFLGWTVIFER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TBS6</accession>
    <name>A0A433TBS6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Antistasin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_013272</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000479">
        <property type="protein sequence ID" value="RUS78970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TBS6"/>
    <dbReference type="STRING" id="188477.A0A433TBS6"/>
    <dbReference type="OrthoDB" id="10021323at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.22.10">
        <property type="entry name" value="Antistasin, domain 1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004094">
        <property type="entry name" value="Antistasin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011061">
        <property type="entry name" value="Hirudin/antistatin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02822">
        <property type="entry name" value="Antistasin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57262">
        <property type="entry name" value="Leech antihemostatic proteins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51252">
        <property type="entry name" value="ANTISTASIN"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019535942" description="Antistasin-like domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Antistasin-like" evidence="4">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Antistasin-like" evidence="4">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Antistasin-like" evidence="4">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Antistasin-like" evidence="4">
        <location>
            <begin position="156"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Antistasin-like" evidence="4">
        <location>
            <begin position="187"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS78970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="232" mass="24434" checksum="4D11ADF67B2926EF" modified="2019-05-08" version="1">MAARPVLSLLSLTLVLVLTDTALALPQLIPVEKTLDPCFPITACKCPFGTVWSIDAKGCPRCSCKPGCPLYKCPAIDCPHGMAKDSNGCPTCGCAPGPVCPEPICPLLKCSNGLATDANGCKICKCNPTVCPAVLCDVLCLNGHIKDSNGCDTCRCNTTVPICPPLCRMHCPNGFVRDSNGCEICKCKPFKPICGPVCMIYCPYGNVLDSNGCPTCRCKKGDLAALDDTLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TDQ3</accession>
    <name>A0A433TDQ3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_012576</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000436">
        <property type="protein sequence ID" value="RUS79653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TDQ3"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22702">
        <property type="entry name" value="PROTEASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22702:SF1">
        <property type="entry name" value="PROTEASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PA" evidence="3">
        <location>
            <begin position="113"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS79653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="235" mass="26311" checksum="C5B9480DB6ABA508" modified="2019-05-08" version="1">MMMLNAIYNLFRQEARMMFPKSEIVMSSLIAVAILPYHELLRGKLPVLTAVYLLLSIFSGHAFDVATIPNRQLVFEDTIYFEIDWPESLRYTYKLSLASGFGTAFSRIYSKVELILSDPEDACQDLYNDVRGAVVLILRGGCSFLTKSKIAQRGGAVAAIVMDDDRNEIDKMIDMADDNTGRTVEIPSAFLTGKDGAMICRHLNIAQTDRAIINIPVNVTGRPLTAIKRPPWTVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TE02</accession>
    <name>A0A433TE02_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_012421</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000426">
        <property type="protein sequence ID" value="RUS79822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TE02"/>
    <dbReference type="STRING" id="188477.A0A433TE02"/>
    <dbReference type="OrthoDB" id="6158295at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019134816" description="CX domain-containing protein" evidence="3">
        <location>
            <begin position="30"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS79822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="395" mass="41713" checksum="B02C6872D473C08A" modified="2019-05-08" version="1">MAASTTYKTVINMFVLTLIVTTILETTEARRGGGGRGGGGRGRSSSSGRGKGSSGGGGYSSTRNYNNVALSGRIMRGSSSYNKNTWRKAAAAGLIFGGAMYLARPRTHRLYNEMPIICTNKTFERDGKRYNNFICPLPDTNDTLKYCCGPESGEYCCDKETAQKYYAEHGSSSGSSPVGMIIGLLVLVIVIAGIVYCCKKSGSGSITKMFRSKREAREPSGMVLNTVNKHESPADPELPSSLVPLNPPANGSYPANAPEYPPPYSANPTAYNSGYGLPYGPPPVGGYAGNPPEQYVPAGVAPYPPPQEPGAPNLYPPPSDGGAVMPPYAPATAPYPAGAPPYPPYPGGDATVAVPPYPGVPLPASAPSYDSHTACTYHLKNVDRFSCRRKTQPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TIU7</accession>
    <name>A0A433TIU7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_010739</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000335">
        <property type="protein sequence ID" value="RUS81483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS81483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="250" mass="28847" checksum="2ECF1A9A70ECFB32" modified="2019-05-08" version="1">MEPVRARGKQKETEKDRETNPHPLTSQARIIEATAKQELHVATLIELRTDQLGGIVTAAPGVPEKLVSALPNARRSVSVAVTVTANTKQEDEEKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXKKKKKKKKKKKKKKKKKKKKKKKKKRETSLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TJM2</accession>
    <name>A0A433TJM2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ADAMTS/ADAMTS-like Spacer 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_010528</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000323">
        <property type="protein sequence ID" value="RUS81721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TJM2"/>
    <dbReference type="STRING" id="188477.A0A433TJM2"/>
    <dbReference type="OrthoDB" id="6149464at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000005">
        <property type="entry name" value="ADAM metallopeptidase with thrombospondin type 1 motif 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013273">
        <property type="entry name" value="ADAMTS/ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045371">
        <property type="entry name" value="ADAMTS_CR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010294">
        <property type="entry name" value="ADAMTS_spacer1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF313">
        <property type="entry name" value="PEPTIDASE M12B DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19236">
        <property type="entry name" value="ADAMTS_CR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05986">
        <property type="entry name" value="ADAMTS_spacer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01857">
        <property type="entry name" value="ADAMTSFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="ADAMTS/ADAMTS-like cysteine-rich" evidence="7">
        <location>
            <begin position="55"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="ADAMTS/ADAMTS-like Spacer 1" evidence="6">
        <location>
            <begin position="146"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS81721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="450" mass="50614" checksum="B137F8DD24E468E3" modified="2019-05-08" version="1" fragment="single">SKDRSDYCQGPATQYISCNVQPCAEGGRDFRFQQCQAYNGVTLFDTRIKNSTWEPYNDVSKPCKLICRAQNGETRTLKDVIDGTSCDSARDLGICVQGICKPVGCDRVLGSTKPDDKCLVCDGDGRDCDTVVDSTRRHRLAQSVVNNVVVFPPEARSVRIKIDSLANVLLELRNGMGDSFQLNQLEQTFASRRLADIDGTLFTYQQDGDSVTYFARGPLEEPLQLQVRYEGDLPLIEFEYSTRREVSRPQSDEAARYIWKFGRWTVCSRDCGDGYQRRAVACLDRETGKRVTNDQCDMREMPSRRQSCNLQPCRNSGNPVYRWTPGTWGDCSVPCGAGQQKQSMLCEETTSSGSSVYVSQELCDRYVGRMPEVERACFGDDCPYWAAGNWADCSVTCGEGQQSRRLYCQRDPPEEDAAPVLVSHDQCPADKRPSEVQVCRQMECRQEPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TK78</accession>
    <name>A0A433TK78_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">U1 small nuclear ribonucleoprotein 70 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_010227</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000309">
        <property type="protein sequence ID" value="RUS82000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TK78"/>
    <dbReference type="STRING" id="188477.A0A433TK78"/>
    <dbReference type="OrthoDB" id="4207594at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001585">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051183">
        <property type="entry name" value="U1_U11-U12_snRNP_70-35kDa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952:SF5">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="43"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00058765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS82000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="91" mass="10037" checksum="D3414606C776F869" modified="2019-05-08" version="1">MYISHDTTRHDKTAAYKNADGKKIDGRRVLVDVERGRTVKGWRPRRLGGGLGGTRKGGPDENVRFSGRDEFSAGNYRGGDDERGGMMPTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TKP9</accession>
    <name>A0A433TKP9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_010116</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000301">
        <property type="protein sequence ID" value="RUS82142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TKP9"/>
    <dbReference type="STRING" id="188477.A0A433TKP9"/>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15040">
        <property type="entry name" value="7tmB2_Adhesion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053066">
        <property type="entry name" value="ADGR_G7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47767">
        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR G7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="501"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="7">
        <location>
            <begin position="110"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="8">
        <location>
            <begin position="289"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS82142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="532" mass="58636" checksum="D1CC6DFCC5FAFF64" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TKW6</accession>
    <name>A0A433TKW6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosyltransferase 2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_009981</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000295">
        <property type="protein sequence ID" value="RUS82243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TKW6"/>
    <dbReference type="STRING" id="188477.A0A433TKW6"/>
    <dbReference type="OrthoDB" id="3971593at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019187">
        <property type="term" value="F:beta-1,4-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027389">
        <property type="entry name" value="B_mannosylTrfase_Bre-3/Egh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16779">
        <property type="entry name" value="BETA-1,4-MANNOSYLTRANSFERASE EGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16779:SF1">
        <property type="entry name" value="BETA-1,4-MANNOSYLTRANSFERASE EGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="486"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="2">
        <location>
            <begin position="263"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS82243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="541" mass="61576" checksum="4137EB34D061A34C" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TKZ6</accession>
    <name>A0A433TKZ6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_009971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000294">
        <property type="protein sequence ID" value="RUS82260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TKZ6"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062101">
        <property type="term" value="F:peptidyl-aspartic acid 3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039038">
        <property type="entry name" value="ASPH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12366:SF29">
        <property type="entry name" value="ASPARTYL BETA-HYDROXYLASE, ISOFORM L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12366">
        <property type="entry name" value="ASPARTYL/ASPARAGINYL BETA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS82260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="308" mass="35843" checksum="10E3F8C6BA43F408" modified="2019-05-08" version="1">MLMFRMVSRRRMLMVRMVVVVVVVVVKRRSRRMVLMMMTWMMKMTMVMVMVRVVIVVVVVVVVVPSMSLFGRSCVFGVNRDEDYGDEDIDDDSNDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDEHFDDPCSSHAITTWWLILCLAVWSAWQDSHLSPGARDCQTRPNAWPGAGCLVRGSSGRLGCLGCLECLEGLEGLEGRECLECLGSLEGRECLGCLECLCLQCQCLEGQCLEGGGQYNWKEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEERRRRRRKKKKKKKIDEEKMNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TL96</accession>
    <name>A0A433TL96_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycerol-3-phosphate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="9">1.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_009977</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 9">
            <text>sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.8" evidence="9"/>
    <dbReference type="EMBL" id="RQTK01000294">
        <property type="protein sequence ID" value="RUS82266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TL96"/>
    <dbReference type="STRING" id="188477.A0A433TL96"/>
    <dbReference type="OrthoDB" id="10263760at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141152">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000004">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000365">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017751">
        <property type="entry name" value="G3P_DH_NAD-dep_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03376">
        <property type="entry name" value="glycerol3P_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728:SF8">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)]-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="2 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal" evidence="10">
        <location>
            <begin position="7"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal" evidence="11">
        <location>
            <begin position="197"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="271"/>
            <end position="272"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS82266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="358" mass="39445" checksum="EA2FD011CD60622A" modified="2019-05-08" version="1">MTSGYRVALIGSGCWGSAIAKIVGLNVLNQPEIFEKEVLMYVYEEIIDGAKLTDIINLEHENVKYLPDIKISPNVIAVPDVVQACTNADILIFVLPHQFVKETCEKMASAIKPGALGLSLIKGFVLSEGEGIQLVSNIIKNTLNIETAVLMGANLATEVASEMFCETTIACHNPEYHPILSRLFQTPYFRVKVIENVAGVEACGALKNVVGIGAGIVDGLGYGDNTKAAVIRLGLMEMMKFTKVFLDSDDISVFFESCGIADLVATCHGGRNRLLGEAVVKSMKLRGWAGVDIRLLEKEILRGQSFQGPLIAKEIYTYLKDHEMLDQYPLFVAIHRICTREVDPRNFIECLRDHPEHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TLU6</accession>
    <name>A0A433TLU6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_009754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000284">
        <property type="protein sequence ID" value="RUS82491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TLU6"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050972">
        <property type="entry name" value="SDr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34403:SF14">
        <property type="entry name" value="OS05G0225800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34403">
        <property type="entry name" value="TOL-PAL SYSTEM PROTEIN TOLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS82491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="214" mass="23733" checksum="8DC4D3109C5A8524" modified="2019-05-08" version="1">MKYCVYTHLHNITVFLHCNNPNPNSNPNRNPNPNPNLNLNPNLNPNPKPNPNLNPNPNPNPNANFNLKLNSIPNPNPNPNLNPNPNPNPNPNPNPNPNPNLNPNPNPNPNPNLNPNPNPNPNLNPYPYPHPKPNPNPKPYPNPNPNHNQLLLFFRPRFREISILTFDLTRPEVEYSPDGLTEPGVDLYHPPSLTPGLLLLSVLGAPSGELVSDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TMN9</accession>
    <name>A0A433TMN9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rap-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_009371</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000268">
        <property type="protein sequence ID" value="RUS82849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TMN9"/>
    <dbReference type="STRING" id="188477.A0A433TMN9"/>
    <dbReference type="OrthoDB" id="2499658at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11210:FF:000001">
        <property type="entry name" value="Ral GTPase-activating protein subunit alpha-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050989">
        <property type="entry name" value="Rap1_Ran_GAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15711:SF32">
        <property type="entry name" value="RAP GTPASE ACTIVATING PROTEIN 1, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15711">
        <property type="entry name" value="RAP GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="2">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS82849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="216" mass="24566" checksum="026BC926E5536078" modified="2019-05-08" version="1" fragment="single">MCYDEHVLTHNFKFGVIYQKKGQTSEEELFGNRTHGPAMDEFLNTIGDRVQLKDFKGFRGGLDTTHCQTGAESVYTRFNGKEVMFHISTLLPYTEGDSQQLQRKRHIGNDIVAIVFQEENTPFVPDMIASHFLHCFIVVQPVSSPSEPTQYRVSTALSVQNWGLPGTALSTSIFDWPSKFREFLLTKLINAEFACYKAEQFAKLGVSSLHLWLVSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TPC8</accession>
    <name>A0A433TPC8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphodiesterase</fullName>
            <ecNumber evidence="7">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_008903</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="7"/>
    <dbReference type="EMBL" id="RQTK01000247">
        <property type="protein sequence ID" value="RUS83356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TPC8"/>
    <dbReference type="STRING" id="188477.A0A433TPC8"/>
    <dbReference type="OrthoDB" id="295473at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000003">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
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        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
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        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0140">cGMP</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="9">
        <location>
            <begin position="797"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="214"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="308"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="620"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
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            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
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            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
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            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="657"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="877"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="881"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="915"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
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            <position position="916"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="916"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
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        <location>
            <position position="1027"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
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        <location>
            <position position="1079"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS83356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1079" mass="121975" checksum="4A0D587298C1EBDA" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TQ24</accession>
    <name>A0A433TQ24_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_008551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000234">
        <property type="protein sequence ID" value="RUS83703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TQ24"/>
    <dbReference type="Proteomes" id="UP000271974">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS83703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="111" mass="12727" checksum="3CCFC35B65CF1561" modified="2019-05-08" version="1">MIHILHDAMMEDTMTRFLKIEGIKDKKLHRIDINDKENHLPIKKINTGANVQAILDQMNSEDRDSFLVRLQGAYIKAGVYMQNKLPMKNKFLKCLSLSAIDPGGHHCLQVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TQ65</accession>
    <name>A0A433TQ65_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_008614</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000236">
        <property type="protein sequence ID" value="RUS83646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="188477.A0A433TQ65"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24188">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24188:SF29">
        <property type="entry name" value="GH09064P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="22"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="88"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="121"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="154"/>
            <end position="186"/>
        </location>
    </feature>
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        <location>
            <begin position="187"/>
            <end position="220"/>
        </location>
    </feature>
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        <location>
            <begin position="221"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="254"/>
            <end position="286"/>
        </location>
    </feature>
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        <location>
            <begin position="287"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="353"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="386"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="419"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS83646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="473" mass="49333" checksum="C6D14757D9C81A5B" modified="2019-05-08" version="1" fragment="single">GHRETIQTLMASGASIQATNVSGQTALMLAAYKGVPEVARELLAAGAEVEAVDHKGWTPLMFSAQYGEQATVDVLLAGHAKLGTADLTGATALHIAAGNGQVDTVRTLLEAGAEVDRVDKKGSTALAQAAAGGHLDCVHELLAHKAALDTRDGTGATALHLAAAEGYSNVVRALTDAKADLNVIDDDGDTPLMCASSQNGHANIVEYLLEKGVDVNSKTIYCRSPLAIAADNGKIQVVEMLVKHGALVDAADVDGKTPLMLAAYSGQRRVVQILLEAGAATDKVNCDGQTALFLASYEGHKKIVETLVQAGADVNLPDRELTTPLMAATLNRHLGTVLKLLDAQADTGAVDRRGRTPLMMACDRGLPGIARRLLALGAGVDRACRAGWTPLMYCCQHGLAELIKLLLEAKADVNLQDNEGNSALGICVANGFLQSAKLLLANGAKVTTQNSSGRSPLIMACYNGFTSSVEYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TQG2</accession>
    <name>A0A433TQG2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-N-acetylglucosaminidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_008394</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000227">
        <property type="protein sequence ID" value="RUS83853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TQG2"/>
    <dbReference type="STRING" id="188477.A0A433TQG2"/>
    <dbReference type="OrthoDB" id="64736at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007781">
        <property type="entry name" value="NAGLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024240">
        <property type="entry name" value="NAGLU_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12872">
        <property type="entry name" value="ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12872:SF1">
        <property type="entry name" value="ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12971">
        <property type="entry name" value="NAGLU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019104182" description="Alpha-N-acetylglucosaminidase N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-N-acetylglucosaminidase N-terminal" evidence="3">
        <location>
            <begin position="39"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS83853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="151" mass="16888" checksum="A55356A997DE35F4" modified="2019-05-08" version="1">MKLLGLIPYITLLSVAVCIDFPQLQILKSWVKSDVQGKAAADLIRRQIGDRVSDFVIEIDQGIGPQDTFELSSLEDGRVRIVANGGVAVAMGFYHYLKYFCNGQRTWAGKQTELPAVLPVLKTAVKVSTPDRSVFICKMYIMMYQSYFIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-05-03" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TR49</accession>
    <name>A0A433TR49_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_008187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000219">
        <property type="protein sequence ID" value="RUS84075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TR49"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS84075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="117" mass="14764" checksum="562A8514E10A694D" modified="2019-05-08" version="1" fragment="single">YSQHYKVGVRINCRHFTYSQHYKVDVRINCRHFTYSHYKVDVRINCRHFTYSQHYKVDVRINCRHFTYSQHYKVDVRINCRHFTYSQHYKVDVRINCRHFTYSQHYKVDVRINCRYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TSW2</accession>
    <name>A0A433TSW2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_007527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000196">
        <property type="protein sequence ID" value="RUS84699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TSW2"/>
    <dbReference type="OrthoDB" id="6095791at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS84699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="119" mass="12745" checksum="03E54ADF6E544DDA" modified="2019-05-08" version="1" fragment="single">PAESRRPSTHSVGILPISMFGEGGEKPRRPSTHSLGVFSFGCLGEDKPDRPRRCSAHSLGPLVVPDFDRRGSRGSIFGTLGISDFVGGTGAGSNSQPNNQRRPSFQAFGESVMQLFNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TW55</accession>
    <name>A0A433TW55_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_006433</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000159">
        <property type="protein sequence ID" value="RUS85804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TW55"/>
    <dbReference type="OrthoDB" id="10043185at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019171820" description="SCP domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="66"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS85804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="310" mass="35087" checksum="9E4809A23737281F" modified="2019-05-08" version="1">MFPRILGISAVCALFVAISLTQDETGSDTTNSTVSTCRPEFFNQTPKHTMCLEDSEHLLDFGVSEEDKQLILDYHNKARREVLPIATDLVQLAWDDNLAEVAQKLAKQCHMYHDSNRKIPGYGTSFGQNLAAGQPHWTRAMDAWFKEKDLFKFGENPNDYLGTNGWKRIGHYTLMISNRILRIGCGYANCKEVRYGTFYACNYVLGQTNFRRPYNNGTERCSACPDSCENGLCDCGGNFCMNKGTLDINTCQCKCQKHYKEANCSRLECPEKDGWRCGGRWPESYCKKYSNVPFECPYMCGTCPVKAGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TW99</accession>
    <name>A0A433TW99_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">vesicle-fusing ATPase</fullName>
            <ecNumber evidence="3">3.6.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EGW08_006345</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">EC2010</strain>
            <tissue evidence="17">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="3"/>
    <dbReference type="EMBL" id="RQTK01000157">
        <property type="protein sequence ID" value="RUS85861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TW99"/>
    <dbReference type="STRING" id="188477.A0A433TW99"/>
    <dbReference type="OrthoDB" id="29072at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02678">
        <property type="entry name" value="MIT_VPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19521">
        <property type="entry name" value="RecA-like_VPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000043">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000015">
        <property type="entry name" value="vacuolar protein sorting-associated protein 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.80:FF:000002">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045253">
        <property type="entry name" value="VPS4_MIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF83">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MIT" evidence="16">
        <location>
            <begin position="5"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="163"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="78"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RUS85861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="441" mass="49377" checksum="FBB1106524BB2AF7" modified="2019-05-08" version="1">MKMKEVQPVNKAIELVTKATEEDKNKNYEEALRCYEHGVEYFLHAIKYEATSDKAKDSIRSKCVQYLDRAEKLKQYLKKKEGKKPVKEGGKSSDKNSDDKSSDEDEDPDKKKFQSQLQEGIVMESPNVKWEDVAGLDKAKDSLKEAVILPVKFPHLFTGKRKPWKGILLFGPPGTGKSFLAKAVATEANNSTFFTVSSSNLVSKWLGESEKLVKNLFLMAREHKPSIIFIDEVDALCSSRSDNESESARRIKTEFLVQMQGVGNDNEGVLVLGATNIPWALDSAIRRRFEKRIYIPLPEAPARSHMFDLHLGTTPHSLTDKDIKELGMRTEGYSGADISIVVRDALMQPVRKVQNATHFRRVRGPSRDNPDVMVDDLLTPCSPGAPGAIEMTWIDVPGDKLLEPIVSMSDMLMSLSNTKPTINDDDLKRLQAFADDFGVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TXF7</accession>
    <name>A0A433TXF7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_005962</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM MRD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000144">
        <property type="protein sequence ID" value="RUS86270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TXF7"/>
    <dbReference type="STRING" id="188477.A0A433TXF7"/>
    <dbReference type="OrthoDB" id="439639at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000277">
        <property type="entry name" value="RNA binding motif protein 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="3"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="130"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="238"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="421"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="95"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="313"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="502"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="527"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="553"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="569"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS86270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="585" mass="64474" checksum="06020B850531002B" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TZ26</accession>
    <name>A0A433TZ26_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_005420</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="RQTK01000127">
        <property type="protein sequence ID" value="RUS86824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TZ26"/>
    <dbReference type="STRING" id="188477.A0A433TZ26"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF13">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019465664" description="non-specific serine/threonine protein kinase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="59"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS86824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="375" mass="43315" checksum="0599A54C6D89FADD" modified="2019-05-08" version="1">MIWLGWPLMVLWIKAPSCDSSNIFSAILVQRKLHREAMASDEENITLNLAMDYFEFFDLHIEKILGRGKTGEVVLAVHDVYPGINRAVKRFSLNEEDLQKRNISLERAKKLFYHELEILRELDHPNVIRGSNGIVCPGYLAIAMDYCPYGTLADHLKKMDTGLIDKCFAGVVAGVRYIHSLRIVHGDIKLQNVFIDTKQQAILGDFGLSYKLPEDVRYVTTTGGTMGYYAPEVLRKIKSVDPFKCDNYAVGVVLRCMVQRRRPDYTSNYLEEIKSIKIEDKFRYFLLALLRTDPFRRSTMAEVERTLIDFSAERYALEISRTRLARPRLVKERRHGYQYMVTIIVSRVSPLDYGKSVYCEVRPRWLQPGSPSWSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U474</accession>
    <name>A0A433U474_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_003641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000078">
        <property type="protein sequence ID" value="RUS88615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U474"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS88615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="199" mass="22098" checksum="8327445ACC1BF747" modified="2019-05-08" version="1">MVSRIRWSLVQTPGRSACNSVVCSSKGRPVTTNWAQGAVKCPEGAAVPCLTSGQEGNSNNTRQPFNAAIADSTPALRDTYPYFQAVPQNTRNVYEIEKDDTNDVDNDDNGGDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDGDDDDGDDDDNDDDDDDDDDDDSEDNDEDGDDDDDDDNDDKDLYSTRDQRQWQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U5M3</accession>
    <name>A0A433U5M3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Neurotransmitter-gated ion-channel ligand-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_003111</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000065">
        <property type="protein sequence ID" value="RUS89103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U5M3"/>
    <dbReference type="STRING" id="188477.A0A433U5M3"/>
    <dbReference type="OrthoDB" id="410315at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18989">
        <property type="entry name" value="LGIC_ECD_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5022263513" description="Neurotransmitter-gated ion-channel ligand-binding domain-containing protein" evidence="5">
        <location>
            <begin position="20"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="455"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="7">
        <location>
            <begin position="34"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="8">
        <location>
            <begin position="239"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="357"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS89103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="54114" checksum="EB796A30B905282B" modified="2019-05-08" version="1">MKWLFTLIIQAAFTITAVPTGIGGATIQQAKDLYSDVILAEDARTRPIVNQSTALEVAISASLFSLLEVDEVKQSISVNVLVRLSWTDEIRKWDPAAYGGLREVDVSSGDIWFPRILNGNSVSKRDTFGSDYAPLYIQNRGMVIFLPGGILHTSCLMDLTHYPFDSQTCSIELVAGSSRNFVVLTPFQAKFDEETYIENSEWDLLNTSLEILNSDFGASLAMFDITIKRKPGHIVLTILVPVNIVSALSNLVFLTPLESGERVSFSITALLALSVYTSEVSKTLPNNSEAVPYMVIYLACLLLHAAAAIVVNLGALMRHHKKQNQQVTRGGQRVDRDSLDGDYISISDDHISDFDGAGRQKLDNGDSGAHSQSAGHIPNSDNTTMSHSQPGNAIALSSSASSTQNKTWRFNLTSMFIACARRLNYGETDFRADAGYRLNKPDGGMSRQPWLYRLLLWMLQFVGLADLIMFLVFFIGWLVITVVFVMLFTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U5T6</accession>
    <name>A0A433U5T6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_003053</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000063">
        <property type="protein sequence ID" value="RUS89174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U5T6"/>
    <dbReference type="STRING" id="188477.A0A433U5T6"/>
    <dbReference type="OrthoDB" id="159395at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016316">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039034">
        <property type="entry name" value="INPP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12187">
        <property type="entry name" value="AGAP000124-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12187:SF11">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3,4-BISPHOSPHATE 4-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="17"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS89174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1051" mass="118823" checksum="BFB7C14BB562E179" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U606</accession>
    <name>A0A433U606_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BACK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_003126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000065">
        <property type="protein sequence ID" value="RUS89118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U606"/>
    <dbReference type="STRING" id="188477.A0A433U606"/>
    <dbReference type="OrthoDB" id="6350321at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF17">
        <property type="entry name" value="KELCH-LIKE PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BACK" evidence="2">
        <location>
            <begin position="129"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS89118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="576" mass="63569" checksum="0CCC831CBBA1712D" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U717</accession>
    <name>A0A433U717_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_002643</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000051">
        <property type="protein sequence ID" value="RUS89625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U717"/>
    <dbReference type="STRING" id="188477.A0A433U717"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000041">
        <property type="entry name" value="Mesoderm-specific transcript homolog protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="7">
        <location>
            <begin position="61"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS89625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="324" mass="36553" checksum="8BDEA1535988C7E3" modified="2019-05-08" version="1">MALQRYVLGGCVLALLAIFLKYPAPRLSTRLQAWKDRGSLMSYKDRNIFYIREKGSGSDGVVVCLHGFPTSSFDWIKILPKLQQLFSHVVMLDFLGFGFSDKPQSHVYTIAEQADIVEKLLGKLGVSQAHILSHDYGDTVALELLARFNEQRLSFDMQSLVMLNGGVFPNTHHPRPLQKVLLMPVLGHVASRLFSYPLFCRGFGEIFGEQKPSKEDYDDFWAALRYNDGDKASVGVINFLRERQTFKERWVGALTQTNIKVLMVYGPADPVNPPEFATHFRATVPRQHLAVLADWVGHYPQWEDPGAVGEQLALFMEGLAAHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U856</accession>
    <name>A0A433U856_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_002257</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000043">
        <property type="protein sequence ID" value="RUS89990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U856"/>
    <dbReference type="OrthoDB" id="6341251at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="4">
        <location>
            <begin position="82"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS89990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="332" mass="37623" checksum="309C6E37E49C1DCC" modified="2019-05-08" version="1">MSSVEEAKIATGQSTNGTTEKSVQKSEPPELPTPDPLNPFHFPDFALPTGIMFNGAPVMKCPVKDDSLTHVQKIRALDMRAEDILITAYPKCGTHWVAEILHMLTSGTSEHNRRTKEYTMLEFCDDLSFLDTLTSPRVLNSHLVMAHLPTQIVDKNVKLVHVIRGPKDTAVSMYHHLKQSASDQFTFDNFIKGYVTGEYIVFSHQFEYLRQMAQFERAHPDQPIMHVHYEDLKQDPSSVIHELSQFIGRPASPAFCHEVASACGFSNMKKADADRTMPESLTKLRTSKLHLYRKGIVGDWKNQFTVAQNEMFDEFLAQQKQKGFGFEPKGHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U8H3</accession>
    <name>A0A433U8H3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_002138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000040">
        <property type="protein sequence ID" value="RUS90096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U8H3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS90096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="111" mass="12785" checksum="841E21D7C404B0CA" modified="2019-05-08" version="1">MLCLCAIETLCWQVVVSCGNNFLFSLSTALGTISGLAKQTRKFFSSSFCCALRCKNFKRSAMSVVIAQSFYVIHAFITLPFLVRLIKTLHRISFVKKRYFSFKRRFIGHFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UC77</accession>
    <name>A0A433UC77_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_000711</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000010">
        <property type="protein sequence ID" value="RUS91490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UC77"/>
    <dbReference type="STRING" id="188477.A0A433UC77"/>
    <dbReference type="OrthoDB" id="3261737at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003878">
        <property type="term" value="F:ATP citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06100">
        <property type="entry name" value="CCL_ACL-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000004">
        <property type="entry name" value="ATP-citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118:SF42">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS91490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="23675" checksum="457F47430BA82884" modified="2019-05-08" version="1">MCLMVTADHGPAVSGAHNTIVCARAGKDLISSLTSGLLTIGDRFGGALDAAARQFSNASDAGLIPMEFVNDMRKKGSLIMGIGHRVKSINNPDMRVVILKEYAQKHFPATPLLDYALEVEKITTSKKPNLILNVDGFIGVAFVDLLRNCGCFTREEAQEYIDIGALNALFVLGRSMGFIGHFLDQKRLKQGLYRHPWDDISYIMPETNNSSNIDCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UCV4</accession>
    <name>A0A433UCV4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EGW08_000697</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">EC2010</strain>
            <tissue evidence="17">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the integrin alpha chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000009">
        <property type="protein sequence ID" value="RUS91582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UCV4"/>
    <dbReference type="STRING" id="188477.A0A433UCV4"/>
    <dbReference type="OrthoDB" id="5317514at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.930">
        <property type="entry name" value="Bicelle-embedded integrin alpha(iib) transmembrane segment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1460">
        <property type="entry name" value="Integrin domains. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1530">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013649">
        <property type="entry name" value="Integrin_alpha_Ig-like_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048285">
        <property type="entry name" value="Integrin_alpha_Ig-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048286">
        <property type="entry name" value="Integrin_alpha_Ig-like_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF133">
        <property type="entry name" value="INTEGRIN ALPHA-PS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08441">
        <property type="entry name" value="Integrin_A_Ig_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20805">
        <property type="entry name" value="Integrin_A_Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20806">
        <property type="entry name" value="Integrin_A_Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0401">Integrin</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1095"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="142"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="290"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="397"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="464"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="527"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha first immunoglubulin-like" evidence="14">
        <location>
            <begin position="574"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha second immunoglobulin-like" evidence="15">
        <location>
            <begin position="733"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha third immunoglobulin-like" evidence="16">
        <location>
            <begin position="905"/>
            <end position="1077"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF20805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RUS91582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1149" mass="126763" checksum="6889320500F74BF4" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z118</accession>
    <name>A0A3S0Z118_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_023824</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01003472">
        <property type="protein sequence ID" value="RUS68414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z118"/>
    <dbReference type="STRING" id="188477.A0A3S0Z118"/>
    <dbReference type="OrthoDB" id="25942at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="2"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="68"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="102"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS68414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="156" mass="17071" checksum="30F3E4416C0A1EA0" modified="2019-04-10" version="1" fragment="single">LFKRSPLMFAADGGHLHIVNYLPKRGANVNLVDGDKDTALLLSVRKGHSGIVQSLINNGADANVRDKNSNTVLWIAVEKNYRECVKFLLQAGADANIRDSRTGYPVLLIAVEKKYIDCVRMLAQAGADVNGQSNAHETALHYAVENSNIDCVRLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z3L5</accession>
    <name>A0A3S0Z3L5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_022220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001512">
        <property type="protein sequence ID" value="RUS70016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z3L5"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS70016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="173" mass="19772" checksum="353914BD54E62A1B" modified="2019-04-10" version="1">MYCSRYANRLLRKIYIYIHIIYFILSSSFVTFVPTSLFTVFVPHLCSLCLCHIHVHCVCATSMFTVFVPHPCSPCLCHIHVHCVCATSMFTVFVPHPCPPCLCHIHVHCVCATSMFTVFVPHPCSPCLCHIHVHRVCATSMFTVFVPHPCSWWVFFCFVFLVQGGHCHNLNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z625</accession>
    <name>A0A3S0Z625_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_022123</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001488">
        <property type="protein sequence ID" value="RUS70114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z625"/>
    <dbReference type="STRING" id="188477.A0A3S0Z625"/>
    <dbReference type="OrthoDB" id="6068455at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="120"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS70114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="647" mass="74739" checksum="27F3F2161DC8E748" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z6Z8</accession>
    <name>A0A3S0Z6Z8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tubulin--tyrosine ligase-like protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_021453</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-glutamyl-[protein] + L-glutamate + ATP = gamma-L-glutamyl-L-glutamyl-[protein] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60144"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:15517"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:143622"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:60145"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tubulin--tyrosine ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001334">
        <property type="protein sequence ID" value="RUS70785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z6Z8"/>
    <dbReference type="STRING" id="188477.A0A3S0Z6Z8"/>
    <dbReference type="OrthoDB" id="2016263at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070740">
        <property type="term" value="F:tubulin-glutamic acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000009">
        <property type="entry name" value="tubulin polyglutamylase TTLL5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241:SF145">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE TTLL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="613"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="947"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="618"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="646"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="682"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS70785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="973" mass="109536" checksum="86F20D68380AD133" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z8M8</accession>
    <name>A0A3S0Z8M8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_022904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001722">
        <property type="protein sequence ID" value="RUS69337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z8M8"/>
    <dbReference type="STRING" id="188477.A0A3S0Z8M8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS69337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="356" mass="39189" checksum="6684E758D196181A" modified="2019-04-10" version="1">MNYLNQNVGNVPMNYLNYNFDSGSNNYLNQNFGNVPMNHLNHNFDNGHMNYLYQSFGNVPMNPLNQNFANVPMNPLNQNFANVPMNPLNQNFANVPMNPLNQNFASGPINPLNQNPGYVTSAINPMNQNLGTCPMNPLIHSLDNGQTGMNLNLGSRPHNNILRPSTLNQNPGNNLVNQSICRGFERPTNHKLVNASNEHADRSLTNSIIQQRNINIPRNPEKKSMDKENNNPNLQYPQSGWKSITDKVPPNQSKILSQQQFNIPITSQSESSIQHRSLNHTNTASSNQGNVTESVTHARSYESIDDLPCLSPDTIIRTLGPLVEDTPAVASSVSPSGSLSASSNQDSGFGTPSLSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z9F6</accession>
    <name>A0A3S0Z9F6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EGW08_018463</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">EC2010</strain>
            <tissue evidence="15">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000902">
        <property type="protein sequence ID" value="RUS73770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S0Z9F6"/>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="29"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000020">
        <property type="entry name" value="Dachsous cadherin-related 1b"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000015">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000021">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000026">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000032">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000033">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000037">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000041">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000064">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000080">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000024">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000039">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000053">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000059">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000092">
        <property type="entry name" value="Protocadherin 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026">
        <property type="entry name" value="FAT ATYPICAL CADHERIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026:SF136">
        <property type="entry name" value="PROTOCADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="29"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="29"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018749858" description="Cadherin domain-containing protein" evidence="13">
        <location>
            <begin position="20"/>
            <end position="3148"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="27"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="148"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="262"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="365"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="472"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="596"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="729"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="837"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="941"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="1047"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="1153"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="1275"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="1370"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="1470"/>
            <end position="1575"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="1584"/>
            <end position="1680"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="1681"/>
            <end position="1778"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="1779"/>
            <end position="1895"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="1912"/>
            <end position="1997"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="1998"/>
            <end position="2099"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="2100"/>
            <end position="2201"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="2202"/>
            <end position="2302"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="2303"/>
            <end position="2411"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="2412"/>
            <end position="2513"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="2531"/>
            <end position="2618"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="2619"/>
            <end position="2725"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="2726"/>
            <end position="2829"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="2830"/>
            <end position="2942"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="2942"/>
            <end position="3042"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="3043"/>
            <end position="3146"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="3148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RUS73770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="3148" mass="346234" checksum="3E9D884CA2479ADD" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZD79</accession>
    <name>A0A3S0ZD79_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_016029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000680">
        <property type="protein sequence ID" value="RUS76222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZD79"/>
    <dbReference type="OrthoDB" id="6067228at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="385"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS76222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="480" mass="55937" checksum="2D97250F28B4511B" modified="2019-04-10" version="1" fragment="single">DYTYPGATVHEVRRSFSEQNVLITEQEDILQFIGLCGGEAATYMGILRSGECLSVRLASSLTFGSRSVIRAYVYYYLRDQDTRDTGGRVPPMVQKMIDRNIKFTGRYYLKSISYGIQEVIVLQFQFVTRAEADRARAISLNSTRMTDYMAQIRTTANTPKVVKIINVSSREPKSYAVAKFHPLSTTVPYQWDRAVRHVSVLERYVEAEKDRIRHPRSPRPHLKYYFAPFLAEELIEGKSESANPYQWRNISMIEATLRRDLKLVRKFTKKCRKNRTPVCKRVRQHREIAAALSREVHRKREQWVKVTAEEQASFIQTYRVKADTNSRLTQNLVKEVRAMRKAMKKKAILDKAKRRNRVPTTTSRAQGNKQRPNRRRNNRGKKLRNGNNTRNGSSTSGEAVQDEQIDLEKQQSQTNDTPELVQQKEQSQTNDTLVEEEVPRPAEQVRFQVDYNRRRMLRARARAMRRQRERARARASSSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZJ62</accession>
    <name>A0A3S0ZJ62_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytospin-A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_013267</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000479">
        <property type="protein sequence ID" value="RUS78965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZJ62"/>
    <dbReference type="STRING" id="188477.A0A3S0ZJ62"/>
    <dbReference type="OrthoDB" id="5972258at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000023">
        <property type="entry name" value="EH domain-binding protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022735">
        <property type="entry name" value="bMERB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050540">
        <property type="entry name" value="F-actin_Monoox_Mical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019448">
        <property type="entry name" value="NT-C2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167">
        <property type="entry name" value="CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167:SF46">
        <property type="entry name" value="EPS15 HOMOLOGY DOMAIN CONTAINING PROTEIN-BINDING PROTEIN 1, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12130">
        <property type="entry name" value="bMERB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10358">
        <property type="entry name" value="NT-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01203">
        <property type="entry name" value="DUF3585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51848">
        <property type="entry name" value="BMERB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51840">
        <property type="entry name" value="C2_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 NT-type" evidence="7">
        <location>
            <begin position="7"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="258"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="BMERB" evidence="8">
        <location>
            <begin position="547"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="375"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="468"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="497"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="507"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS78965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="659" mass="75091" checksum="EE63B36E927F0C21" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZLN5</accession>
    <name>A0A3S0ZLN5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_021948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001446">
        <property type="protein sequence ID" value="RUS70271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZLN5"/>
    <dbReference type="OrthoDB" id="10570334at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS70271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="748" mass="82059" checksum="294BBB40767F42BF" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZMJ0</accession>
    <name>A0A3S0ZMJ0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flavoprotein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_011037</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000350">
        <property type="protein sequence ID" value="RUS81207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZMJ0"/>
    <dbReference type="STRING" id="188477.A0A3S0ZMJ0"/>
    <dbReference type="OrthoDB" id="1532798at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF6">
        <property type="entry name" value="PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="3">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS81207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="210" mass="23437" checksum="B5D99C5229BCC337" modified="2019-04-10" version="1">MNVLVGCTGSVASVKIPQLVDNLLDLDIKPNVKVVTTSNALHFFNKTDVKAPVLCDKDEWEMWSGRGDPVLHIELRRWADLFLIAPLDANTLAKIAGGICDNLLTCVVRAWDSKRPLLFAPAMNTQMWQHPITAKHIETLKSFGYQEIPCVSKLLECGDTERYKAVTLPDPKPVAPSRWMNSRKKGSELSIGFMLHILTSSNDVIQPPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZMM8</accession>
    <name>A0A3S0ZMM8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phosphotransferase</fullName>
            <ecNumber evidence="14">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EGW08_010944</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">EC2010</strain>
            <tissue evidence="17">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the phosphorylation of various hexoses to hexose 6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16126"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-glucose + ATP = D-glucose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17825"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:17826"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-mannose + ATP = D-mannose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11028"/>
            <dbReference type="ChEBI" id="CHEBI:4208"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:11029"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the hexokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="14"/>
    <dbReference type="EMBL" id="RQTK01000345">
        <property type="protein sequence ID" value="RUS81302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZMM8"/>
    <dbReference type="STRING" id="188477.A0A3S0ZMM8"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24019">
        <property type="entry name" value="ASKHA_NBD_HK_meta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000095">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000005">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019807">
        <property type="entry name" value="Hexokinase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF16">
        <property type="entry name" value="HEXOKINASE TYPE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00378">
        <property type="entry name" value="HEXOKINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 14" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="15">
        <location>
            <begin position="24"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="16">
        <location>
            <begin position="226"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RUS81302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="477" mass="53829" checksum="031B7E43D172B073" modified="2019-04-10" version="1" fragment="single">MSLEEKRCRKAKPVFIEPVDQAMVENILKPLDLTDERYRKVMDVMRQNLEEGLHPDTHADANIKCFPTYVRSVPDGTENGDFLALDLGGTNFRVLLINLNGQEVTMESKIYIIPQHIMLGSGDQLFDHIADCIFKFMCDHDLHDRTLPLGFTFSFPCRQVGLDKAILTTWTKGFKCDGVEGHDIVGLLHQAIQRRGDMKNVRCLAVINDTVGALMSCAHSDRNCAIGLILGTGTNACYIEDLPNVKTWDGDYNEPKQVLINSEWGAFGNDGCLDFILTDFDRSIDKHSINPGKQIYEKMISGMYMGEIARLAIERLRKHNLLFEGEGSYHLSTRGRFYTKYVSEIEGDDVDNFTVTKQIFDELELACHNEQDCRLVFFTIDIYNNNCLFSVPGIACLLNKMGRKEATVGVDGSLYRFHPFFHDLMMEKISQLIKPNLSFKLMLSHDGSGKGAALVAAVASRLQKQEEAKNQSTEELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZNE1</accession>
    <name>A0A3S0ZNE1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable DNA packing protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_020738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001204">
        <property type="protein sequence ID" value="RUS71487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZNE1"/>
    <dbReference type="OrthoDB" id="10460789at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038435">
        <property type="entry name" value="DNA_pack_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003499">
        <property type="entry name" value="DNA_pack_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02500">
        <property type="entry name" value="DNA_pack_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Probable DNA packing protein N-terminal" evidence="1">
        <location>
            <begin position="163"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS71487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="783" mass="88849" checksum="FD4B33B7A6F4A416" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZPR6</accession>
    <name>A0A3S0ZPR6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycolipid transfer protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_019822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001070">
        <property type="protein sequence ID" value="RUS72417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZPR6"/>
    <dbReference type="STRING" id="188477.A0A3S0ZPR6"/>
    <dbReference type="OrthoDB" id="116883at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902387">
        <property type="term" value="F:ceramide 1-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902388">
        <property type="term" value="F:ceramide 1-phosphate transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF43">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="1">
        <location>
            <begin position="56"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS72417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="233" mass="26940" checksum="539C78C6659B8900" modified="2019-04-10" version="1" fragment="single">EIFYSWGRRYKVVGTTQGQFFLFGSVASTQPFSIDHVRTLFTQSLQSDARGNTVLKLDSYIEAYTELSRVFDFFGVVFSFAREDIMSKLSTLTTLRTVDRRRRHHYDTFESMFAYEYSHAALLQEQPGVSCNRWIHRALRFISRVVEEVKQESSADLQSRVRVHYDNILAPHHSWFVRSAARLALNSFPSRDQFLSAIHVADTPVGMGKLTQAVSVMDQVYNHVQGLYDRYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZQZ8</accession>
    <name>A0A3S0ZQZ8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">3-hydroxyacyl-CoA dehydrogenase type-2</fullName>
            <ecNumber evidence="3">1.1.1.53</ecNumber>
            <ecNumber evidence="4">1.1.1.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">3-hydroxyacyl-CoA dehydrogenase type II</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Mitochondrial ribonuclease P protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Type II HADH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">EGW08_011466</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">EC2010</strain>
            <tissue evidence="21">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(3S)-3-hydroxybutanoyl-CoA + NAD(+) = acetoacetyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30799"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57316"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:30800"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:30801"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>11-dehydrocorticosterone + NAD(+) = pregn-4-ene-3,11,20,21-tetraone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42020"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78600"/>
            <dbReference type="ChEBI" id="CHEBI:78601"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:42021"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>17beta-estradiol + NAD(+) = estrone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16469"/>
            <dbReference type="ChEBI" id="CHEBI:17263"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:24613"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>17beta-hydroxy-5alpha-androstan-3-one + NAD(+) = 5alpha-androstan-3,17-dione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15994"/>
            <dbReference type="ChEBI" id="CHEBI:16330"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:41993"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>3beta,7beta-dihydroxy-5beta-cholan-24-oate + NAD(+) = 3beta-hydroxy-7-oxo-5beta-cholan-24-oate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42024"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78602"/>
            <dbReference type="ChEBI" id="CHEBI:78603"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:42025"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42004"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16330"/>
            <dbReference type="ChEBI" id="CHEBI:36713"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.53"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:42006"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>5alpha-pregnan-20beta-ol-3-one + NAD(+) = 5alpha-pregnane-3,20-dione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42008"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28952"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78594"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:42009"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:22433"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="6">
            <dbReference type="Rhea" id="RHEA:22434"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>cortisol + NAD(+) = 11beta,17alpha-dihydroxypregn-4-ene-3,20,21-trione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42012"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17650"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78595"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:42013"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>cortisone + NAD(+) = 17alpha-hydroxypregn-4-en-3,11,20-trione-21-al + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42016"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16962"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78596"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:42017"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ursodeoxycholate + NAD(+) = 7-oxolithocholate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42028"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78604"/>
            <dbReference type="ChEBI" id="CHEBI:78605"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:42029"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 20">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.53" evidence="3"/>
    <dbReference type="EC" id="1.1.1.62" evidence="4"/>
    <dbReference type="EMBL" id="RQTK01000374">
        <property type="protein sequence ID" value="RUS80743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZQZ8"/>
    <dbReference type="STRING" id="188477.A0A3S0ZQZ8"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047044">
        <property type="term" value="F:androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004303">
        <property type="term" value="F:estradiol 17-beta-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008209">
        <property type="term" value="P:androgen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008210">
        <property type="term" value="P:estrogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05371">
        <property type="entry name" value="HSD10-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000215">
        <property type="entry name" value="3-hydroxyacyl-CoA dehydrogenase type-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658:SF8">
        <property type="entry name" value="17-BETA-HYDROXYSTEROID DEHYDROGENASE 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00050365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00050435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00072938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00082293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00082399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RUS80743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="261" mass="27476" checksum="BB17D576A5F54147" modified="2019-04-10" version="1">MASTIGALKNAVGLVTGGASGLGRATVERFVREGARVVLCDLPTSNGKEVADSLGKNCVFAPTDVTSEADVTQALETVKSNFGRLDMAVNCAGIGVAFKTYNFNKKRPHDLADFQKVLMVNTAGSFNVIRLAAGVMGEQEPNADGQRGVVVNTASVAAYDGQMGQAAYSASKGAIVGMTLPIARDLASHGIRVVTIAPGLFDTPLLASLPEKVRKFLASTIPFPSRLAHPDEYAHLVQAVYENPMLNGEVIRLDGALRMMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZVZ1</accession>
    <name>A0A3S0ZVZ1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fanconi anemia core complex-associated protein 24 pseudonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_015663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000651">
        <property type="protein sequence ID" value="RUS76585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZVZ1"/>
    <dbReference type="STRING" id="188477.A0A3S0ZVZ1"/>
    <dbReference type="OrthoDB" id="5975714at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043240">
        <property type="term" value="C:Fanconi anaemia nuclear complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20076">
        <property type="entry name" value="XPF_nuclease_FAAP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026985">
        <property type="entry name" value="FAAP24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040646">
        <property type="entry name" value="PND"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31786">
        <property type="entry name" value="FANCONI ANEMIA CORE COMPLEX-ASSOCIATED PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31786:SF2">
        <property type="entry name" value="FANCONI ANEMIA CORE COMPLEX-ASSOCIATED PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17949">
        <property type="entry name" value="PND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fanconi anemia core complex-associated protein 24 pseudonuclease" evidence="1">
        <location>
            <begin position="14"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS76585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="191" mass="20576" checksum="AA4976D159448F45" modified="2019-04-10" version="1">MRRPHPPSSRGCASIPVHFENSASAIDFYPSSSVGMVFISEADTVEGCSYKRKVARLRKARSVRGAVIVEKTATSAQYFLDVQKFCVGNLGLHLVPVKNQSEAAAFLIQVVYAEGKLDSNPFKKEVKRESSDPAVLAAIMSCRGVGSSSARAILETFPSLELLCKASLGELTSVVGKASAGKFYQFLHDVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZWF7</accession>
    <name>A0A3S0ZWF7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_015286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000621">
        <property type="protein sequence ID" value="RUS76966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZWF7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018581465" evidence="1">
        <location>
            <begin position="27"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS76966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="238" mass="26047" checksum="B3CC6D09AE8750FB" modified="2019-04-10" version="1">MVVVVVAAVFMVVMEMVTEMAELSDGQAVTECGDSNPNGNTIDFSEPSSPGPFHDLTELEMKKTLPRDVCWGLSQSMADPIPLPFLNLDVNWCLFCASPHLLVGYGLGPSDFNLACASWYLCERRQMSSAKSKSSNCLAKVHCMPVFVPVVEARITQSMTIKKIVGDSRQPCRTPVSTLKGSRIVTISITQSSHSDARSAVREYVFWAVHTGTKLRPGSRVVALADWLLCILIPIILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZWJ9</accession>
    <name>A0A3S0ZWJ9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="17">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">EGW08_007461</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">EC2010</strain>
            <tissue evidence="19">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Golgi apparatus membrane</location>
            <topology evidence="2 17">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="17"/>
    <dbReference type="EMBL" id="RQTK01000193">
        <property type="protein sequence ID" value="RUS84777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZWJ9"/>
    <dbReference type="STRING" id="188477.A0A3S0ZWJ9"/>
    <dbReference type="OrthoDB" id="6072411at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23437">
        <property type="entry name" value="beta-trefoil_Ricin_GALNT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000053">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF68">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12 17" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 17" id="KW-0430">Lectin</keyword>
    <keyword evidence="16 17" id="KW-0464">Manganese</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ricin B lectin" evidence="18">
        <location>
            <begin position="493"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RUS84777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="623" mass="71718" checksum="DF42F87D877A8ED6" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZXI3</accession>
    <name>A0A3S0ZXI3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein yippee-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_003088</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the yippee family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000064">
        <property type="protein sequence ID" value="RUS89145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZXI3"/>
    <dbReference type="STRING" id="188477.A0A3S0ZXI3"/>
    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="5">
        <location>
            <begin position="13"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU110713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS89145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="119" mass="13704" checksum="DF220C4DD517288A" modified="2019-04-10" version="1">MGRIFLQHIGGSRIFTCGNCNIALTNRDELISTRFTGATGRAFLFDRVVNLQYSDVQDREMLTGRHMVRDVSCKFCNSKLGWIYEFATKDDQRYKEGRVILERALVHEVEGMDEPVNHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZZ33</accession>
    <name>A0A3S0ZZ33_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase M13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_002000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000037">
        <property type="protein sequence ID" value="RUS90219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6154552at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF133">
        <property type="entry name" value="PHOSPHATE-REGULATING NEUTRAL ENDOPEPTIDASE PHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="3">
        <location>
            <begin position="130"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS90219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="197" mass="22009" checksum="DA08853CFF2F6E55" modified="2019-04-10" version="1" fragment="single">MTTTSRGEDEAWISNKQPEDNNGDTPQIRYKQDRGVLKKRTTLEKILLGVLAFVLLVLLIVVILFIVSSNNNSSSNKHDKDAVSSGPKSSASSGLTPDVVTHQNVEICLTKGCINAXXXXXQDIDYSVSPCEDFHQFACGRWMKKHAIPEDQASYNRFSILREQVQVVLRNLLQEEHKPGDLDCMKKAKDLYASCVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZZB0</accession>
    <name>A0A3S0ZZB0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_001867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000034">
        <property type="protein sequence ID" value="RUS90372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZZB0"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS90372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="257" mass="29511" checksum="7120FF6012E45F74" modified="2019-04-10" version="1">MCSWGVCLNVFVGRVFECVRGACVVSSSGILHFSNWLTLNTPLALASLLHVVVLRVLYLYSHCNCNKPIYINKKVFAVHVLFFFVPRFLAVNSLNFVFLGFEFVKSSIYMRSLHTTCSRVLAFVLFLSMFILGLSLARGELFLSESTRKQSVSSMYGTRVSLGTFDMYPVVRKVKDIYIDTSCKREVIQLHALLRSNTEHFRFRNIYINYIFLNFICLYPQGSIYNLTSPVCSFLLLLLLLLLLLLLLLLLWLLLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A0N8</accession>
    <name>A0A3S1A0N8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_001362</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000023">
        <property type="protein sequence ID" value="RUS90855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A0N8"/>
    <dbReference type="STRING" id="188477.A0A3S1A0N8"/>
    <dbReference type="OrthoDB" id="5141738at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17317">
        <property type="entry name" value="MFS_SLC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS90855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="472" mass="51526" checksum="3D13FDFE3CD5DA55" modified="2019-04-10" version="1" fragment="single">NHPINGSRYLESCPSGWVYEHDILTNNAVNQLDFVCDRSDLKTHAAMMLYLGSLLGATVLGIISDRYGRRVCLMLSVTILLPCGIGLPWVQHFETLAVLQFLCGAASTGMFASSFVMGLELVDPKARKVPGLVTQMFFSVGEFLLAASTYGLGDWRWVSLIITVPTATFFSYFWCVPESLRWLMVHKKYDQVSKVLTRMAAHNGVDPPTSDDGDTERDLEKLLESYQADGEFSVSVTKKDSFLDLFKSCVLAGRTLTICLNWAVVNLIFYGFTLNAGNLKAGSKYVNFSIGAAVEIPAHLTTLALVDKIGRKRVHCGLLLLAAIMCAGSVGVALGCDEGHQWIVAVLAMVGKYCAAGLMGTSFLWMTELFPTSVRSTGLGVGSSCARIGALISPYIVHYSLDISDPKLGHATPFIVFGLASLLAFVFDLCLPETYGRDAPETVEEAKHFGREPESEVLRVQEEGRHHYGSMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A721</accession>
    <name>A0A3S1A721_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EGW08_007954</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">EC2010</strain>
            <tissue evidence="15">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="11"/>
    <dbReference type="EMBL" id="RQTK01000210">
        <property type="protein sequence ID" value="RUS84310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A721"/>
    <dbReference type="STRING" id="188477.A0A3S1A721"/>
    <dbReference type="OrthoDB" id="275509at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF174">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="14">
        <location>
            <begin position="80"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="12">
        <location>
            <begin position="300"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="13">
        <location>
            <begin position="600"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="458"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RUS84310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="789" mass="88935" checksum="30A9B35E39FB8AEA" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A9P7</accession>
    <name>A0A3S1A9P7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_005980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000145">
        <property type="protein sequence ID" value="RUS86238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A9P7"/>
    <dbReference type="STRING" id="188477.A0A3S1A9P7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS86238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="135" mass="14971" checksum="1B9F051C38469A53" modified="2019-04-10" version="1" fragment="single">SLTHTLSLTHPLSLTHPLSLTYSPTVMHLLTHCHLLTHCHLLTHTLSLTHTLSLTHSLTVIYSHTVTYSHCHLLNHTLSLTHSLSLTHSLSLTHTLSLTHPLSLTHTLSFTHTLSLTHTLSLTHSPTVTYSHTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AAG0</accession>
    <name>A0A3S1AAG0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_005469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000129">
        <property type="protein sequence ID" value="RUS86746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AAG0"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS86746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="316" mass="34699" checksum="7E5F15F41D2940D2" modified="2019-04-10" version="1">MQTSPSDGAQSTSLRENPDSPRKQAQPERDFAHCSPSGGYKCIDSGVQTSPPGYAQPISLRENHDISVKQTQPERSLSQSYPLKGNNRIDSGVQTSPPGRAQSISFIDNQNSSKSMKNSQPQDFAQYSPSSGNIRTEPGVQTSPANSAHSNSLRFSQVVSQKQTQPDRNFAQCSSSIGNNRIDSGVQTSPSDGVRSIDLRDRQVISLKQNQPERKYERQPSSSGINRIDSGVQTDATQSISLRNHHDSSKTQILYLPERAFVKYLPVKGETRPMPSVNSDTAAGSQFIYVKDNRDNSRSPKESSVWVKVLARGSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AAM3</accession>
    <name>A0A3S1AAM3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_005361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000125">
        <property type="protein sequence ID" value="RUS86882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AAM3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS86882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="202" mass="22369" checksum="DAC6446E088E2ACE" modified="2019-04-10" version="1" fragment="single">MEDLDVGTSESVGRGSVKMRTKKKSTLAKLKEKKIREQGSLTSLQSYHEKEDEKSFFKESSQAHKNTHSKMLTSTGSIESDIVISTKDPPETATGRTRPKPRPRGRRQSSHDSETGPSKSDTHDINTNSDLSLQDKLKDLKLAGPYGDGADSTISNSGFLPKPPETPRSQISNPRTPRSYIPMNKEEKKSKEHLSGEEAETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AGM3</accession>
    <name>A0A3S1AGM3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_000729</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000010">
        <property type="protein sequence ID" value="RUS91508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AGM3"/>
    <dbReference type="OrthoDB" id="6050800at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34415">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34415:SF1">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS91508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="202" mass="22901" checksum="279ADE6C5BC22510" modified="2019-04-10" version="1">MSDMYYGYTYKQLRVFAYEMAVSNNIAIPQYWKDNKMVRINWQKGFVARNGEGLSSTSTRATVACASNKERYTKFSPDAGFGLLKRKFRRTRVDCLGDIKHVVDSSSEMNSAKLVGAESGPSQVLTYDWSSYLSQFFVKVKQVKSFHHFTMNNSGTIVVKEYNNTGEQQQVLLKKVGAAGAAESGDKNNDQISPRIGFKYWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AQK1</accession>
    <name>A0A3S1AQK1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycoside hydrolase family 38 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_023008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001769">
        <property type="protein sequence ID" value="RUS69229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AQK1"/>
    <dbReference type="STRING" id="188477.A0A3S1AQK1"/>
    <dbReference type="OrthoDB" id="9980604at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10791">
        <property type="entry name" value="GH38N_AMII_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032482">
        <property type="entry name" value="DUF5054"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16477">
        <property type="entry name" value="DUF5054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS69229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="758" mass="85572" checksum="8139ED9D27E58149" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1ASU0</accession>
    <name>A0A3S1ASU0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kazal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_021088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001264">
        <property type="protein sequence ID" value="RUS71149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1ASU0"/>
    <dbReference type="OrthoDB" id="6150188at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018781814" description="Kazal-like domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS71149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="17230" checksum="EDD24CAA33DB9D17" modified="2019-04-10" version="1" fragment="single">MEVFVFMFATLCGLVLSVSGQTDENCNGRIVSCFANPCSVASCPGVSNAECVPNFCNRCSATFVVNGFTVSEADCEKSPLTSADHVIVKEEPILVLGGAKTVVKDPGALQSPNSGDSNPTLGGIKRVFSDPASRDGPTLGGGKIMRSGSGPQRLNSRNSPLLAGLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AU39</accession>
    <name>A0A3S1AU39_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PLAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_020110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001108">
        <property type="protein sequence ID" value="RUS72123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AU39"/>
    <dbReference type="STRING" id="188477.A0A3S1AU39"/>
    <dbReference type="OrthoDB" id="5965014at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018559627" description="PLAT domain-containing protein" evidence="3">
        <location>
            <begin position="26"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="532"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="627"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="661"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="805"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="891"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1043"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="891"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="923"/>
            <end position="1001"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS72123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1089" mass="123619" checksum="EB02CA57BD4B5480" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AV80</accession>
    <name>A0A3S1AV80_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_019130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000976">
        <property type="protein sequence ID" value="RUS73108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AV80"/>
    <dbReference type="STRING" id="188477.A0A3S1AV80"/>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS73108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="129" mass="14159" checksum="52BE17221994B85D" modified="2019-04-10" version="1">MSDVVDDINDKHMQPWSDACQRDGIVNTPLTPFIDQELLYNKHINIDGTRIESTGFTYSHPTLELSSMREILEDYVQLGLLPASLTGREAFYSRSDVDLLQAGASGVDLGGHGDSADFVGEAEEDPRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AY11</accession>
    <name>A0A3S1AY11_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cationic amino acid transporter C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_017059</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000765">
        <property type="protein sequence ID" value="RUS75178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AY11"/>
    <dbReference type="STRING" id="188477.A0A3S1AY11"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061459">
        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015189">
        <property type="term" value="F:L-lysine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097638">
        <property type="term" value="P:L-arginine import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243:SF105">
        <property type="entry name" value="CATIONIC AMINO ACID TRANSPORTER C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243">
        <property type="entry name" value="INNER MEMBRANE TRANSPORTER YGJI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS75178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="39451" checksum="A64DAA5F3230CB18" modified="2019-04-10" version="1" fragment="single">MAFVIGWNLILEYVIGTASMARAWSVYFDNMIGNHISGFFQQTMPIHVSWLSAYPDFFALGITLVLTALLIFGVKESAKFNNVFTGINLLVVLYIILCGLFKIDTHNWNLDPSEVPADKGDGGFMPYGISGTMAGAATCFYAFVGFDVVATTGEEAKNPQRATPIAIVVSLAIVFLSYFSVSTVITLMSPYFLLDPNAALPQAFERVGWGFARYFISVGALCGLSASLLTGMVPLPRILYAMGNDGVIYRFMGEINPRTKTPLVGTAISGVFSGLMAMVFDLHELVDMMSIGTLLAYTLVSVSVLILRYECDTNLQIGTHSEKGNRNKEAQPSQFFPALKFNLKTLILPDSNEPTKVTALVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B010</accession>
    <name>A0A3S1B010_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_015695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000654">
        <property type="protein sequence ID" value="RUS76540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS76540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="218" mass="24188" checksum="8D64ED1C5C81A39F" modified="2019-04-10" version="1">MYASDKKLKFAAAHYETAHVGKCALQQRHWWHDDDDDDDDDDDDDDDDDDDDDDDDDDDXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDENDDDDDDDDDDDDDDDDDDDDDGGGGGGGGGVGGDVGNVDESKGGDYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B1A2</accession>
    <name>A0A3S1B1A2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_018518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000907">
        <property type="protein sequence ID" value="RUS73712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B1A2"/>
    <dbReference type="OrthoDB" id="6185633at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018551203" evidence="1">
        <location>
            <begin position="20"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS73712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="132" mass="12971" checksum="27DDFA58F2C0396F" modified="2019-04-10" version="1">MKTFTVLAVVALLCYTANATPCTDICNAQCTIQQQSCAFTEIFGNLCDTIAGICGQACTAACGCADSCAAQCGGEYATCKGAASGPLGGLNVLSCGLNLGVCSSTCQLQCNFNLLAGVVNSLGGAGATTATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B296</accession>
    <name>A0A3S1B296_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_014090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000530">
        <property type="protein sequence ID" value="RUS78142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B296"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS78142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="200" mass="21280" checksum="9F8A83CF196E3838" modified="2019-04-10" version="1">MNLTTTTFVVVVVVDVDDDVDDGDDDDDDDDDDDDDDNDEDNDEDDMNYGDNDGPGGPGGPGGPGGPEGLGLGGPEGLGPGGPEGLGPGGPGGPEGLGPDAASASDDNDDEDDDEDDADDEGNGDDDNNDDYVDHNDYNDKYYDDNDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDYCHVYIVTTLYLHAQIRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B2E2</accession>
    <name>A0A3S1B2E2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_018874</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000944">
        <property type="protein sequence ID" value="RUS73372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B2E2"/>
    <dbReference type="OrthoDB" id="10614210at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS73372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="715" mass="78584" checksum="4D8D59B848E8645E" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BAX4</accession>
    <name>A0A3S1BAX4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_008208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000220">
        <property type="protein sequence ID" value="RUS84030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BAX4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS84030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="138" mass="15479" checksum="4BC5AEE119357353" modified="2019-04-10" version="1" fragment="single">PQLCIAVYLCFCVSPAVYQAVYLCFCVSPAVYQAVYLFLYFVSPAVYQAMFLFLCVSPAVYQAVYLCFCVSPAVYQAVYLFLCVSPAVYQAMFLFLCVSPAVYQAVYLYCVSPAVYQAVYLCFCVSPAVYQAVYLFLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BBV8</accession>
    <name>A0A3S1BBV8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_015218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000617">
        <property type="protein sequence ID" value="RUS77016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BBV8"/>
    <dbReference type="STRING" id="188477.A0A3S1BBV8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.50">
        <property type="entry name" value="Insect antifreeze protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053359">
        <property type="entry name" value="CRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016133">
        <property type="entry name" value="Insect_cyst_antifreeze_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35577:SF7">
        <property type="entry name" value="CYSTEINE-RICH, ACIDIC INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35577">
        <property type="entry name" value="CYSTEINE-RICH, ACIDIC INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51156">
        <property type="entry name" value="Insect cysteine-rich antifreeze protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS77016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="274" mass="28319" checksum="D944635AEBA8916B" modified="2019-04-10" version="1">MEETVEICPDGEDYGGDCKDVKICPDGGDCKDVKICPDGGDCKDVKICPDGGDCKDVKICPDGGDCKDVKICPDGGDCKDVKICPDGGDCKDVKICPDGGDCKDVKICPDGGDCKDVKICPDGGDCKDVKICPDGGDCKDVKICPDGGDCKDVKICPDGGDCKDVKICPDGGDCKDVKICPDGGDCKDVKICPDGGDCKDVKICPDGGDCKDVKICPDGGDCKDVKICPDGGDCKDVKICPDGGDCKDVKICLDGGHCKDLKICPDGGHCRGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BCW4</accession>
    <name>A0A3S1BCW4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_014522</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
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            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
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                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Elysia chlorotica</name>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
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                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
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                <person name="Shigenobu S."/>
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                <person name="Nishiyama T."/>
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                <person name="Pierce S.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24390:SF159">
        <property type="entry name" value="GROWTH FACTOR INDEPENDENT 1 TRANSCRIPTIONAL REPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24390">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS78820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="184" mass="21011" checksum="7BA38DB1114C356F" modified="2019-04-10" version="1" fragment="single">LRCSQCAFTTTIEKCLLKHERKCRGEAGIHCPLCAVHYSDSPEELCIHKRRHHRPVKLTCFLCEFKSRSISKLPIHVCKLCLKTMSGETHEDSHWRKAVYACELCSYRAADGLGLRLHVRLHSADGPRACGLCCRKFSQRDHLDSHIGTHTNERPFNCPICDYAAKQMQHLKTHLVTNTCKGPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BG98</accession>
    <name>A0A3S1BG98_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_009251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000263">
        <property type="protein sequence ID" value="RUS82966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S1BG98"/>
    <dbReference type="OrthoDB" id="6153184at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16897:SF2">
        <property type="entry name" value="OS03G0226600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16897">
        <property type="entry name" value="OS10G0105400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2891"/>
            <end position="2939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="2896"/>
            <end position="2919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2927"/>
            <end position="2939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS82966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="2939" mass="318373" checksum="13AA0C6E19F3531A" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BII8</accession>
    <name>A0A3S1BII8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_007832</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000206">
        <property type="protein sequence ID" value="RUS84448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BII8"/>
    <dbReference type="STRING" id="188477.A0A3S1BII8"/>
    <dbReference type="OrthoDB" id="272810at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23453">
        <property type="entry name" value="beta-trefoil_Ricin_VPS13D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056748">
        <property type="entry name" value="VPS13-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009543">
        <property type="entry name" value="VPS13_VAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF141">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25037">
        <property type="entry name" value="VPS13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25036">
        <property type="entry name" value="VPS13_VAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 13 VPS13 adaptor binding" evidence="2">
        <location>
            <begin position="5"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Intermembrane lipid transfer protein VPS13-like C-terminal" evidence="3">
        <location>
            <begin position="937"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS84448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1099" mass="121332" checksum="EA6E685955C2B4AF" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BIV7</accession>
    <name>A0A3S1BIV7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_007416</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000192">
        <property type="protein sequence ID" value="RUS84801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BIV7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS84801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="164" mass="18777" checksum="1599D3CB06EB0DEF" modified="2019-04-10" version="1">MFCYNIIGWCEVKSYVYIVYIPKKKLFTHIFSVMFPLGLEKFQINYAQQNNWINPYFDEFFSSAHFSFTPLHFECIYLSLSSLAACCFLPFVSILSLFGIDCISLSLSLSLSFSLSPSLSLPHTHTHTHTHCLLLLVESVIGPMYDADKHVNIVSSIAYHVIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BK33</accession>
    <name>A0A3S1BK33_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_002186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000041">
        <property type="protein sequence ID" value="RUS90073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BK33"/>
    <dbReference type="OrthoDB" id="6084396at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="40"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS90073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="149" mass="16987" checksum="80C229C397E63DE5" modified="2019-04-10" version="1">MAQNGAKDEALTIFSKYQSSFARRLKKPEAMSLLQTEFGLTEAEADIMFQAFDKDHNEVLSLWEFRQFYQTIGANAHDMIQMFRSIEDGDSGNVDMEKTFDALKTVETGKGRLTDDEIENFLKATAGESKTIDLHKFLNLLCRLKVYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BLD3</accession>
    <name>A0A3S1BLD3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_022433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001570">
        <property type="protein sequence ID" value="RUS69806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BLD3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS69806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="584" mass="63222" checksum="C9F0076096B8AA0A" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BNP2</accession>
    <name>A0A3S1BNP2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Metalloendopeptidase</fullName>
            <ecNumber evidence="8">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_020989</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7 8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="8"/>
    <dbReference type="EMBL" id="RQTK01001246">
        <property type="protein sequence ID" value="RUS71254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BNP2"/>
    <dbReference type="STRING" id="188477.A0A3S1BNP2"/>
    <dbReference type="OrthoDB" id="6156706at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="9">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="9"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS71254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="386" mass="43215" checksum="814ABB7D9816B7E6" modified="2019-04-10" version="1">MRELTSLTCITFREVDSSYTDKPVLDFMKGYGCWSHVGREQAYPFQEMSVAESCFMKGIILHELGHVIGFWHEQSRPDRDDYVTFVQENVNRRESYNFKMETWGDIDSYGVPYDVGSIMHYGSTSYSKNGEVTLRSKDPLLQRSMGQRERMSFYDIKAANMAYCKDVCSTVTFSCLHDGYPDPKDCSRCRCPDGLHGSRCQAAAPSVESCGGCFPTLQPQVPCLLAKTESCMLKWLAQEYVACPVYFRVLTSACNKYITRQHSRPSVCHREEEQCCTGFQLRDGMCHATEEAILNMGNVDSGTTGDSSGKLPQPQATADPLSGWMNWAPWSTCSASCGGCGRRGRVRNCSKISMCGGKLEDRETQVCNYQPCPKYQAYACVASLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BQN9</accession>
    <name>A0A3S1BQN9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_003138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000065">
        <property type="protein sequence ID" value="RUS89130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BQN9"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS89130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="245" mass="28434" checksum="9C5A7484E672D412" modified="2019-04-10" version="1">MREQSFPGGSPTLSRVARSTRSGPVNFYGSQDLPVTSEEDSWRKLARPKTGSLYAPCDGQFYHWGGQSNDSVCSDTYAWNIFSRPCLMTSSPRPQPTPWRQYDLDHPRPTEGILFDPKRNGFYSWSKPNRMDNQRFTSQDGLSDQESWSQSTITSRSGSGYDVNGNTVSSNSRRRFYGRRDRSRNCLDVSLILCRHELRRLFPEEDSEDEEPTHSVQENRKEVQKYSTFHRNLTRRRDEELLRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BVW0</accession>
    <name>A0A3S1BVW0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Nuclear hormone receptor HR96</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_002211</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear hormone receptor family. NR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000042">
        <property type="protein sequence ID" value="RUS90024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BVW0"/>
    <dbReference type="STRING" id="188477.A0A3S1BVW0"/>
    <dbReference type="OrthoDB" id="6352325at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06929">
        <property type="entry name" value="NR_LBD_F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050234">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001728">
        <property type="entry name" value="ThyrH_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082:SF283">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR HR96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00546">
        <property type="entry name" value="THYROIDHORMR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="119"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="13">
        <location>
            <begin position="268"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="16"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="206"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="501"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="523"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS90024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="547" mass="61851" checksum="E69C2FBBC6D297EC" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BWW5</accession>
    <name>A0A3S1BWW5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Centrosomal protein of 76 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_001405</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CEP76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000024">
        <property type="protein sequence ID" value="RUS90786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BWW5"/>
    <dbReference type="STRING" id="188477.A0A3S1BWW5"/>
    <dbReference type="OrthoDB" id="5527234at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046599">
        <property type="term" value="P:regulation of centriole replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052299">
        <property type="entry name" value="CEP76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028926">
        <property type="entry name" value="CEP76-C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056288">
        <property type="entry name" value="CEP76_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056289">
        <property type="entry name" value="CEP76_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056290">
        <property type="entry name" value="CEPT76/DRC7_peptidase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46436">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 76 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46436:SF1">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 76 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15627">
        <property type="entry name" value="CEP76-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24652">
        <property type="entry name" value="CEP76_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24654">
        <property type="entry name" value="CEP76_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24656">
        <property type="entry name" value="CEPT76_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CEP76 N-terminal" evidence="9">
        <location>
            <begin position="10"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="CEP76 C2" evidence="7">
        <location>
            <begin position="98"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="CEP76/DRC7 peptidase-like" evidence="10">
        <location>
            <begin position="360"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Centrosomal protein of 76 kDa C-terminal" evidence="8">
        <location>
            <begin position="519"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF15627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS90786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="659" mass="73850" checksum="F10E912B4B0479CC" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BXX4</accession>
    <name>A0A3S1BXX4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_014502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000556">
        <property type="protein sequence ID" value="RUS77743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BXX4"/>
    <dbReference type="STRING" id="188477.A0A3S1BXX4"/>
    <dbReference type="OrthoDB" id="6114487at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS77743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="19617" checksum="3E7600E7049C99AB" modified="2019-04-10" version="1">MKCVTHYTNVNPLATIVATGKATGPDNISVELLEALDDYGMDKITSLLNEIYETGQIPADITKSIFIALPKKPGATECELHRTISLMSHMTKLHRTISLMSHMTKILLRIIMKGVRNKIKPEIAEEQCGFVEGKGTANAIFILRNLLERALEVKKDVYLCFIDYTKALTEYATMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BYA6</accession>
    <name>A0A3S1BYA6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_014181</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000535">
        <property type="protein sequence ID" value="RUS78069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BYA6"/>
    <dbReference type="STRING" id="188477.A0A3S1BYA6"/>
    <dbReference type="OrthoDB" id="5948003at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF293">
        <property type="entry name" value="A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018601907" description="Ig-like domain-containing protein" evidence="4">
        <location>
            <begin position="26"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="171"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="273"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="273"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="290"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS78069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="389" mass="43839" checksum="5AA9CA266AD84D13" modified="2019-04-10" version="1" fragment="single">MAPPHRGLCFLDLWVLFVTVGLTSAQNYDQEPASWELSDFGLCSSPCGGGLQTRHVNCVRRISWATFSNSMKIRVANSECPKPAPPKSQSCNDHKCQAEWSPQEWSRCSTTCGLGTQTRRVHCTVSWGRRTLLPGGDQHLVSDSECGGSRPLTSRACHLMDCPVMEDPDQPLIEAENYTLWQLSKTKRLTANVGGQLNLLPGQNVVIRCPVRHSSAEELIYWTKDRKLLSLYDHLTIRRASLARDAGTYTCTAQHDSANITINFIKSRGAVDSYNSTNRNNSSNIRRRQQRDQSHQERNKHVRRGERDRTRKKQDMTPAFVTGAWSRCNATCSSRGQRSREVTCSQVTRKFAKVMPETECLKSGLVKPNATISCFHRGRCAIWMPGHWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C208</accession>
    <name>A0A3S1C208_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ERC protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_011467</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Presynapse</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000374">
        <property type="protein sequence ID" value="RUS80744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C208"/>
    <dbReference type="STRING" id="188477.A0A3S1C208"/>
    <dbReference type="OrthoDB" id="2019763at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048788">
        <property type="term" value="C:cytoskeleton of presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098882">
        <property type="term" value="F:structural constituent of presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007274">
        <property type="term" value="P:neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048167">
        <property type="term" value="P:regulation of synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019323">
        <property type="entry name" value="ELKS/CAST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18861:SF0">
        <property type="entry name" value="BRUCHPILOT, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18861">
        <property type="entry name" value="ELKS/RAB6-INTERACTING/CAST PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10174">
        <property type="entry name" value="Cast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0770">Synapse</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="208"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="711"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="881"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1066"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="283"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="387"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="497"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="946"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="886"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="909"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1071"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1097"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1145"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1167"/>
            <end position="1184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS80744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1215" mass="137554" checksum="C9774E6958F5763C" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C3R4</accession>
    <name>A0A3S1C3R4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_010044</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000299">
        <property type="protein sequence ID" value="RUS82162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C3R4"/>
    <dbReference type="STRING" id="188477.A0A3S1C3R4"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050479">
        <property type="entry name" value="CYP11_CYP27_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279:SF120">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS82162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="39610" checksum="841AFC10921E77DC" modified="2019-04-10" version="1" fragment="single">MGAEELAETFFKYASESIAVVCFNTRLGFLEPQSRRSVDTERFSQASLKHFQLLMHSVTGESVAHRFYRNKTYREFEDTCNVMNEITDKYLHKAIAEVQAKKEKQSFDPNEPNLLYSFLSDSTLNYTRIKVIMNNLYNGGTDSTAKNLMVLLYNLAMNQDKQQKLYEEIQTVLGSEEPLTKDALAMMPYLKACLRESFRLINPTALSALRVLHHDTVIRGYRIPAGVTVAYSTHKSSREDFVEPERYVPERWLRDQKQRREEESHILANIPFGYGARGCLGRWFAEQEIYLATVKILQSLQVDVHPESQHVKFGYAIFVEPDKPIQFLFTPRETSGEKSSTMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C611</accession>
    <name>A0A3S1C611_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_008285</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000224">
        <property type="protein sequence ID" value="RUS83930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C611"/>
    <dbReference type="OrthoDB" id="6072422at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="458"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="24"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="270"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="575"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="582"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS83930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="710" mass="80918" checksum="EAAF590290F5638C" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1CGL1</accession>
    <name>A0A3S1CGL1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_000267</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000003">
        <property type="protein sequence ID" value="RUS92054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1CGL1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS92054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="56" mass="6470" checksum="6881947E2BAA712C" modified="2019-04-10" version="1" fragment="single">FSTCRSVIIECCTSSFCSCRKWKDTELTKNDTCRRSNCTRPSMLRTLFSLLPICLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1GY08</accession>
    <name>A0A3S1GY08_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Regulator of rDNA transcription protein 15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_023803</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01002934">
        <property type="protein sequence ID" value="RUS68435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1GY08"/>
    <dbReference type="OrthoDB" id="6107234at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052997">
        <property type="entry name" value="RRT15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047:SF8">
        <property type="entry name" value="REGULATOR OF RDNA TRANSCRIPTION PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS68435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="139" mass="15081" checksum="8674E43879526335" modified="2019-04-10" version="1">MIGRADIEGSKSNVAMNAWLPQASYPCGNFSDTSCLKLLKSKGSIGHAFTVCIRTENQNQASFCPFALREVSVLAELALGHLRYLLTDVPPQSNSPPDTVFRADCARRTVGTPRGPCRTAMPRLIPESRGASPALRFTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H075</accession>
    <name>A0A3S1H075_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_022613</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001619">
        <property type="protein sequence ID" value="RUS69626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H075"/>
    <dbReference type="OrthoDB" id="2413960at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Cas12f1-like_TNB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051491">
        <property type="entry name" value="Recombinase/Transposase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36172">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36172:SF1">
        <property type="entry name" value="RESOLVASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="Cas12f1-like_TNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Probable transposase IS891/IS1136/IS1341" evidence="5">
        <location>
            <begin position="254"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Cas12f1-like TNB" evidence="6">
        <location>
            <begin position="386"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS69626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="459" mass="52878" checksum="758C9334D9139B04" modified="2019-04-10" version="1">MAEIIRKQLWYPGYKPENLSGVVEKLKEVGASNDESALGTFKIKLRPTAYQKACLKRVLAASNLAWNWTKWLIEEKGVSWKDKKTMQAIVVKKSIESLENQDMVAPEVRANQQLLSKTTSVRLTAMCSFVAATKSSMTLHKGCTRKFDVGYKELYPRSGTFGVQKPYIRKFEESMLPAKMPTEARKNFNRLRLSILPNSFAAKGNPNERFLRIGKRRSWESMPPISHDCKVEMRKDGSWLLLIPCDRSYLRFSKPVAEKNHAVSLDPGVRTFQTEYNPFKQETRNHGSQRDKDRINFFKTKAQRHEVLAKTNKKEYVRKEHKRQADKYWHKHGKYRDNIHRELASKLVNENDLVIVGDFSSSRCAAKRAGSKLTKQTRAEMYSWAHYRFKQRLIERARGTGTRVHFQDESYTSKTCGNCGNIKEDLGGNKTYACEVCGVVMDRDVNGARNIMIKSLTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H9B2</accession>
    <name>A0A3S1H9B2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glycosyltransferase family 92 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_017486</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000802">
        <property type="protein sequence ID" value="RUS74757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H9B2"/>
    <dbReference type="OrthoDB" id="6146740at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461:SF69">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="369"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="432"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="305"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="369"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="461"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS74757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="667" mass="76295" checksum="EDAA26D90E11C789" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SIA9</accession>
    <name>A0A433SIA9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_023632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01002234">
        <property type="protein sequence ID" value="RUS68603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SIA9"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS68603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="601" mass="67357" checksum="CDF3D777F46574BF" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SM54</accession>
    <name>A0A433SM54_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7869 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_022003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001455">
        <property type="protein sequence ID" value="RUS70232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SM54"/>
    <dbReference type="STRING" id="188477.A0A433SM54"/>
    <dbReference type="OrthoDB" id="6161632at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057191">
        <property type="entry name" value="DUF7869"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25273">
        <property type="entry name" value="DUF7869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7869" evidence="2">
        <location>
            <begin position="256"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS70232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="486" mass="56772" checksum="B17423D0413C6B52" modified="2019-05-08" version="1">MEHMETQLTKDPTNQELQKKILDIRKEIEIRMVGEIRGAQIRSGFPPKDRRGKHFNRPHRVSDERHERIRSQISSFRGRLSHYSRHKSRKLYLPAELNIMKMFALYEQQYGDGVSYDTYRQIFNGDFNISFGYPRTDTCAICDEFFAGLTNINKELDASPEDANLLRQKAEIVAHRELHQRKSETFYERKRNAKVKAKRLETMRAVAFDFQKELYCPSKTSNDVYYKRQLSDHSFNVHDLGSDYVDFYCYDETIGKKGSDAVASMLSKYVMEVVPETVKEIEFFCDSCCGQNKNYTIFRFFYFLVHCRNRFDKIKVMFPERGHSYMECDRDFSIVNTKSEVELPQEWFRVIREARKSLSPYAVYEMGLCDFKDFTGFLKLRHPFPNSTFFFSALDSGPGSTLSGFEKDLAETKQSLAETKQSLSETKQILSETKQSLSETKKAKYKDLQVLKKFCSPTTHQYYEQLPHDGCTPDALHEKSGGSDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SN83</accession>
    <name>A0A433SN83_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_021559</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001354">
        <property type="protein sequence ID" value="RUS70683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SN83"/>
    <dbReference type="STRING" id="188477.A0A433SN83"/>
    <dbReference type="OrthoDB" id="6156654at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS70683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="19272" checksum="A312469ABED77688" modified="2019-05-08" version="1">MAKRRKGIWRGKDTRQRKHHNTVTSTGNLGPTNRSLFDPQTKRSPLFPRWTPWVVTLVTFAIRVHHVMQPRNWWVLHPDEIYQSMEVAHSELFGYGHRPYEFIAPPKGNNLSHRGGGVAHSELFGYGHRPYEFIAPPKGNNLSHYQLRELTLNKKTNFTIISFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SP07</accession>
    <name>A0A433SP07_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_021293</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001298">
        <property type="protein sequence ID" value="RUS70948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SP07"/>
    <dbReference type="OrthoDB" id="6271941at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051527">
        <property type="entry name" value="KLR_subfamily_B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46784">
        <property type="entry name" value="KILLER CELL LECTIN-LIKE RECEPTOR SUBFAMILY B MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46784:SF1">
        <property type="entry name" value="KILLER CELL LECTIN-LIKE RECEPTOR SUBFAMILY B MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019119732" description="C-type lectin domain-containing protein" evidence="3">
        <location>
            <begin position="26"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="186"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS70948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="480" mass="54568" checksum="0AC69E647118D3F4" modified="2019-05-08" version="1">MYTRTRGCRLVILALALTALCGTHADECVIDQDEEFNRTVCPQGWFETGSKNCLLFYNERLNQSAARAVCHKQDANLVRLYDDTMTREHHEYVLQRMNYTTEVWVALTYNSDSGNSTWPGETNQGTFFVGRRRSKAGHSCTTLVMTQGFLNAQLCDGVEYNYTCEIVKPAGGCPLGWHPLGDLKWCLYGDIKVASYTNASATCEAFNGTVITFKDYQKFMILNAFFRRVWLDASDEGNPSRFYWSNGALLGELVTEERHTHLVENCLSVDVNSYTRNDDYCSLEIPFACQKESEMGEGYPVMEINPRFITVEPDFFYGRLWKNVFFEGDDITVTCRALRLPNGTVGWTFKSSFSIGRKYIKFTRFNNMDNWVVNSVGTILLDDTCVNQTVSTFSTPALKNITFGFPSCYSKIQETYSMCPPGGEPLMFCDTTFEFNIIDRPLKGPEFRLEFSSRSHILVAGEWLVAHCQVYPVQANPRCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SPE6</accession>
    <name>A0A433SPE6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BING4 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_021135</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001273">
        <property type="protein sequence ID" value="RUS71102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SPE6"/>
    <dbReference type="STRING" id="188477.A0A433SPE6"/>
    <dbReference type="OrthoDB" id="10251154at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000378">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012952">
        <property type="entry name" value="BING4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040315">
        <property type="entry name" value="WDR46/Utp7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085">
        <property type="entry name" value="WD-REPEAT PROTEIN BING4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08149">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01033">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="294"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="BING4 C-terminal" evidence="8">
        <location>
            <begin position="379"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="487"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="500"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS71102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="556" mass="63191" checksum="CAD7B66F4A65CEEA" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SPP0</accession>
    <name>A0A433SPP0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Beclin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_021019</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001252">
        <property type="protein sequence ID" value="RUS71220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SPP0"/>
    <dbReference type="STRING" id="188477.A0A433SPP0"/>
    <dbReference type="OrthoDB" id="20368at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043548">
        <property type="term" value="F:phosphatidylinositol 3-kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.40:FF:000001">
        <property type="entry name" value="beclin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.40">
        <property type="entry name" value="Autophagy protein 6/Beclin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007243">
        <property type="entry name" value="Atg6/Beclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038274">
        <property type="entry name" value="Atg6/Beclin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041691">
        <property type="entry name" value="Atg6/beclin_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040455">
        <property type="entry name" value="Atg6_BARA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768">
        <property type="entry name" value="BECLIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768:SF4">
        <property type="entry name" value="BECLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04111">
        <property type="entry name" value="APG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17675">
        <property type="entry name" value="APG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Atg6/beclin coiled-coil" evidence="5">
        <location>
            <begin position="128"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Atg6 BARA" evidence="4">
        <location>
            <begin position="258"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="138"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS71220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="50882" checksum="5D42B7359D35BCD4" modified="2019-05-08" version="1">MSNARMEAGKAGAAFVHFCCQSCKLPLKLDSSFNDLSREMYKELAEPLASSSDMEESIQFVRPEPDFVFEEAEDFSRISIPSGGFEESNDFTFLGDPGPGSIGTMSIRSKVTGQLFDLMSGYSEIDHPLCEECTDHLLDNLDHQLKIVEDENKEYREYLEKLGYSEEVTREPELNEELKQLMQEEKQLQQELVQAERERAKVAEAMAAEKEKADKLTEEEERYWREYNDQCRIAIELEEEQKSVDNQLKYAQVQLDRLKKTNVFNATFHIWHDGEFGTINDFRLGRLPGTTVEWSEINAAWGQVVLLLVSLANKIGLKFKKYRPVPYGNHSYIEVLDENKQLPLYGSGGIRFLWDTKFDSAMVAFLECLQQFRDEVEKEDSSFNLPYKMSKGKIYEGEKTQYSIKMQFNSEEQWTKALKYMLTNLKWALAWLSARKSLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-05-03" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SPZ1</accession>
    <name>A0A433SPZ1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_021025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001253">
        <property type="protein sequence ID" value="RUS71215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SPZ1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS71215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="147" mass="17826" checksum="805A2C346A9C468B" modified="2019-05-08" version="1" fragment="single">IHALIYKSNCNNDNQMFNLYITSRNNDNLRFDLCNTSRNNDNLRFDLYNTSRNNDNLRFDLYNTSRNNDNLRFDLYNTSRNNDNLRFDLYNTSRNNDNLRFDLCNISRNNDNLRFDLCNTSRNNDNQRFDLYNPSRNNDNLRFDLCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SQK7</accession>
    <name>A0A433SQK7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_020708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001201">
        <property type="protein sequence ID" value="RUS71523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SQK7"/>
    <dbReference type="OrthoDB" id="10017343at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031526">
        <property type="entry name" value="DUF4698"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34754">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34754:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS71523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="241" mass="27314" checksum="66989CE2C90E815B" modified="2019-05-08" version="1" fragment="single">RDPRSYVKAEPLPIPPATGLKLQARSDTVFNPTVPSRDDVRKWNYHRRKMQMSEQGFNALNYKPYKGIGDPFYLDEKKLILHSLGQWDENQEWETSSSSEEEDENTSSADAPKASMTAAKFVLRRTRKDLNTLNKEVVKGRSMIRNVRLGHGLFDLIRQERLAKKVAAAAEKKKSLEQQRNQWQAARDSSSDADSDAGCDVNANQSDLDEDLGKDEDLENYFGPSIPDNHNDVGITNDTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SRB7</accession>
    <name>A0A433SRB7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_020454</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001159">
        <property type="protein sequence ID" value="RUS71785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SRB7"/>
    <dbReference type="STRING" id="188477.A0A433SRB7"/>
    <dbReference type="OrthoDB" id="332250at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903724">
        <property type="term" value="P:positive regulation of centriole elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039893">
        <property type="entry name" value="CEP120-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022136">
        <property type="entry name" value="DUF3668"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21574">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 120 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21574:SF0">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 120 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12416">
        <property type="entry name" value="DUF3668"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="600"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="674"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS71785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="961" mass="110462" checksum="C9F3B887EFCCD31E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SRR2</accession>
    <name>A0A433SRR2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transforming acidic coiled-coil-containing protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_020272</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TACC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001135">
        <property type="protein sequence ID" value="RUS71959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SRR2"/>
    <dbReference type="STRING" id="188477.A0A433SRR2"/>
    <dbReference type="OrthoDB" id="10255048at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1700:FF:000001">
        <property type="entry name" value="Transforming acidic coiled-coil-containing protein 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039915">
        <property type="entry name" value="TACC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007707">
        <property type="entry name" value="TACC_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13924">
        <property type="entry name" value="TRANSFORMING ACIDIC COILED-COIL CONTAINING PROTEIN 1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13924:SF10">
        <property type="entry name" value="TRANSFORMING ACIDIC COILED-COIL PROTEIN, ISOFORM K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05010">
        <property type="entry name" value="TACC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transforming acidic coiled-coil-containing protein C-terminal" evidence="9">
        <location>
            <begin position="461"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="461"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="185"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="347"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS71959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="647" mass="71294" checksum="2CC77E7BB55EC4E6" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SW77</accession>
    <name>A0A433SW77_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_018730</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000928">
        <property type="protein sequence ID" value="RUS73515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SW77"/>
    <dbReference type="STRING" id="188477.A0A433SW77"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="516"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="572"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="654"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="654"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS73515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="842" mass="92480" checksum="4F4E6E3485495E9B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SXS0</accession>
    <name>A0A433SXS0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7802 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_018155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000867">
        <property type="protein sequence ID" value="RUS74092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SXS0"/>
    <dbReference type="OrthoDB" id="188749at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056704">
        <property type="entry name" value="DUF7802"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35982">
        <property type="entry name" value="AGAP005361-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35982:SF1">
        <property type="entry name" value="SPIROCYCLASE, AVEC FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25085">
        <property type="entry name" value="DUF7802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7802" evidence="2">
        <location>
            <begin position="21"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS74092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="421" mass="49160" checksum="82A89D41B827CFB0" modified="2019-05-08" version="1">MDEYITLVRETVHKLMPKNAKEVEWWVKFRKPEDILKKHATYLYLEVVLYVLSFLTFCHAMRSGGRFRWLWFATIAHGLTVESLSYFVPDIDNFWHAQSMVMFLGQRLPLHIILLYPVFIYTACAAVSHMNLRWWAEPFAVGLSVVLIDIPFDIMGIKLLWWTWHDDDPNIFDRHYWVPWTSYYFHATFASSFTLLFFGLRRLLCRPGLKYQSCGFFCELPILIITGLFAMPLGILQFVPVYHPLHDSMGIHSEVCVLLLLAVYALIVWSADRTPYEGARLSSSSFSAITLLIHLHYAFYVYLVFNAKPEGERSYGLHQQIGNCNVPVKVMTPFGQVLKKNKFLCVDRYDEGYFNFKCVKKVPAANTEWYTICGTPYENHAEYILVVCSFCAIGVFWFMHLLFFSGPQPRTQKAPRKQHRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T043</accession>
    <name>A0A433T043_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytoskeleton-associated protein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_017345</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CKAP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000789">
        <property type="protein sequence ID" value="RUS74899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T043"/>
    <dbReference type="STRING" id="188477.A0A433T043"/>
    <dbReference type="OrthoDB" id="6288182at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029197">
        <property type="entry name" value="CKAP2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15297">
        <property type="entry name" value="CKAP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytoskeleton-associated protein 2 C-terminal" evidence="7">
        <location>
            <begin position="237"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="52"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="144"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF15297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS74899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="340" mass="38418" checksum="4E848D60155ECD0C" modified="2019-05-08" version="1" fragment="single">MPSNHTTRTGLFPTITKKEETQSKSTVKQRETVKTTVKKEKSPVASILKRKGAANLKRKSAPASFTPNSERHVKFKSKASEQESLREKLNSWLLAKGKTPSRCRHLMCFNEQVSAKKRKGQPEDCLVDRTITQNLLSEQLKVLKNEESNKAETEKNQLEDGPSSAKKPRRSTEKENRQTRRSIRFCDETDEQASDPKEEQISFRKEPACPEAPQSPVPDMIRAAASGQEWSGEKVLQHLNSLLEECLTLYDSGCPLDNLLPWLADIEAYVPRALTFAPYYICKAKVLSAFPRQVLDVFCQAVRNDAQPRELLAQEMNASLSLLLIPPPPELPPISPRHKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T074</accession>
    <name>A0A433T074_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_017303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000784">
        <property type="protein sequence ID" value="RUS74948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T074"/>
    <dbReference type="STRING" id="188477.A0A433T074"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000178">
        <property type="entry name" value="Calmodulin-2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS74948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="22545" checksum="EA767BE9CD969650" modified="2019-05-08" version="1">MRDLPWCVDADKLDTSLMEYGSFSFPKSLKGLGNSALNDKLRIVSWTSVLLHLGQTHEIPLDKILNYLSTSNLRGSTSMWGRRAISQREAKKTNTKEASIPRPEEVVELTEDQKLELREAFSMFEKTGGKGRIPARDLGELLRCLGWNPSEQDLEEARHELELTTRGTISFPEVEAYIARRGGIYNGANAEEDIMVAFQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T178</accession>
    <name>A0A433T178_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_016934</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000753">
        <property type="protein sequence ID" value="RUS75313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T178"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS75313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="233" mass="25674" checksum="A2AAA3EA5348B19D" modified="2019-05-08" version="1">MERAGTQPDNQSTRQPVNQATSQPDNQSTRPAGPGTELSPSLGFQDVTARWGQLSTSATRTASCVTCAGLLYVSLFFIVIVKHFASCFLLPICLSLPSFTPILCKQWNQLSAHTLDVSSRHYSPGAGFPEPPGAVRARTVGDEWAVRQIQYRLQNTDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDENDNDFAQLALQSAYSLAPDDLRPVPSPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T2T1</accession>
    <name>A0A433T2T1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_016388</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000705">
        <property type="protein sequence ID" value="RUS75867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T2T1"/>
    <dbReference type="STRING" id="188477.A0A433T2T1"/>
    <dbReference type="OrthoDB" id="423283at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046928">
        <property type="term" value="P:regulation of neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45911">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45911:SF3">
        <property type="entry name" value="DYSFERLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="8"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS75867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="139" mass="15993" checksum="DCA9152D2CAD263D" modified="2019-05-08" version="1" fragment="single">MSMEAETIIYGLPLTEDQAENAQTRLLRIKVIEGVNLAKKDIFGASDPYVKVSLNDSGTLVDVKQTSIVRKSLNPKWYEEFIFRVNPERNNLLFEVFDSNRVTRDDFLGMVDFTLNMTTISKERAGRDISCRNFVLRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T3B0</accession>
    <name>A0A433T3B0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Metalloendopeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_016221</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000693">
        <property type="protein sequence ID" value="RUS76016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T3B0"/>
    <dbReference type="STRING" id="188477.A0A433T3B0"/>
    <dbReference type="OrthoDB" id="6131366at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.20.10">
        <property type="entry name" value="Plasminogen Kringle 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031569">
        <property type="entry name" value="ApeC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000001">
        <property type="entry name" value="Kringle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038178">
        <property type="entry name" value="Kringle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19324:SF33">
        <property type="entry name" value="MUCIN-5AC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19324">
        <property type="entry name" value="PERFORIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16977">
        <property type="entry name" value="ApeC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00051">
        <property type="entry name" value="Kringle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00130">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50070">
        <property type="entry name" value="KRINGLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0420">Kringle</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0768">Sushi</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CUB" evidence="10">
        <location>
            <begin position="348"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Kringle" evidence="11">
        <location>
            <begin position="468"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="12">
        <location>
            <begin position="584"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS76016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="699" mass="77161" checksum="CD4A3DF631E831F8" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TAL6</accession>
    <name>A0A433TAL6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_013613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000498">
        <property type="protein sequence ID" value="RUS78643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TAL6"/>
    <dbReference type="STRING" id="188477.A0A433TAL6"/>
    <dbReference type="OrthoDB" id="7492290at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009306">
        <property type="entry name" value="DUF963"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06131">
        <property type="entry name" value="DUF963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS78643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="101" mass="10336" checksum="DD9776C260B63C24" modified="2019-05-08" version="1" fragment="single">VNTTVVSKATIVSKDTVVNKATVVNKATVVNKATVVSKATIVSKATVVSKATVVNKATIVNKATIVSKATVVNKATVVNKATVVNKATIVSKATVVNKAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TED2</accession>
    <name>A0A433TED2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ras-related protein Rab</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_012305</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The small GTPases Rab are key regulators in vesicle trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000420">
        <property type="protein sequence ID" value="RUS79917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TED2"/>
    <dbReference type="STRING" id="188477.A0A433TED2"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045335">
        <property type="term" value="C:phagocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090385">
        <property type="term" value="P:phagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04107">
        <property type="entry name" value="Rab32_Rab38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002133">
        <property type="entry name" value="Ras family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030697">
        <property type="entry name" value="Rab29/Rab38/Rab32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF39">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS79917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="238" mass="26743" checksum="30928ED8DDFBDB2B" modified="2019-05-08" version="1">MATAAGLELNSTAAAVTGRTEHLYKVLVIGEFGVGKTSLIRRYTEGNFSPNYKLTIGVDFALKCLEWDNNTKINLQLWDIAGHERFGHMTRVYYKYALLSNKMCMYCFESPQWLEDVNSKVMLANEDPVPVMLLANKCDIDDITVEVEKMNNFCKDKNFIGWYQTSAKTGMNIEECMQFLVEHVLSLPSGAKKPRDRMTNSMGAMENIEISSSASERMESRELARNRGGGDERGGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TEJ2</accession>
    <name>A0A433TEJ2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Notch ligand N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_012253</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000417">
        <property type="protein sequence ID" value="RUS79988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A433TEJ2"/>
    <dbReference type="OrthoDB" id="6162843at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011651">
        <property type="entry name" value="Notch_ligand_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07657">
        <property type="entry name" value="MNNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019513844" description="Notch ligand N-terminal domain-containing protein" evidence="7">
        <location>
            <begin position="25"/>
            <end position="1883"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1811"/>
            <end position="1834"/>
        </location>
    </feature>
    <feature type="domain" description="Notch ligand N-terminal" evidence="8">
        <location>
            <begin position="25"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="262"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="434"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="531"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="627"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="699"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1006"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1043"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1242"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1337"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1507"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1607"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1723"/>
            <end position="1747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="439"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="538"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="636"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="648"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="659"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="708"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1008"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1046"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1059"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1347"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1507"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1537"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1724"/>
            <end position="1737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS79988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1883" mass="208339" checksum="7CD4320218D60FEA" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TGI2</accession>
    <name>A0A433TGI2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_011531</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000377">
        <property type="protein sequence ID" value="RUS80708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TGI2"/>
    <dbReference type="STRING" id="188477.A0A433TGI2"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00878">
        <property type="entry name" value="Arf_Arl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000412">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="29"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="132"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS80708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="189" mass="20838" checksum="A9DF3D04A22769D4" modified="2019-05-08" version="1">MGLLMSKLFEVLQGFSTGTNSSTRVLMLGLDAAGKTTILYKVKLNETVCTIPTIGFNVETVTPVKGVTFTVWDVGGQEKIRQLWKYYYANTQGLLFIVDSADRLRLEEAKSELFGILQSADMARVPVVVVANKQDLPGALSTAEVAHGLGMREMRNRKWHVQGACAVNGDGVFESMQEMARLVKEVYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433THM9</accession>
    <name>A0A433THM9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_011160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000356">
        <property type="protein sequence ID" value="RUS81074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433THM9"/>
    <dbReference type="STRING" id="188477.A0A433THM9"/>
    <dbReference type="OrthoDB" id="5406014at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF194">
        <property type="entry name" value="INVERSIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="164"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="317"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="516"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="567"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS81074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="612" mass="66896" checksum="3DF8734A5CC43808" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TLX1</accession>
    <name>A0A433TLX1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_009657</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000280">
        <property type="protein sequence ID" value="RUS82583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TLX1"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006857">
        <property type="term" value="P:oligopeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="359"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="587"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS82583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="658" mass="73189" checksum="4C57237776C1855C" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TQA7</accession>
    <name>A0A433TQA7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_008505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000232">
        <property type="protein sequence ID" value="RUS83754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TQA7"/>
    <dbReference type="OrthoDB" id="10473394at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS83754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="206" mass="23341" checksum="A0894B39AA0D17DC" modified="2019-05-08" version="1">MLLDIKELGDRKPSEVMDKMLALLGHHRPCFLFHNILSRLLPEAIRAPLANSSNISDYRALAKEADNLYNSLTTNVKSFRGEEITVTNSLTPMYYSATANEVACRSVGNRLYLLVPPQVRIKCQTMHQPLQTFSNFQTKRKPGKRESGPALDCQSVGPLCFAATRPTSEPKISQLRRTTLDDNLRLRLTTDKSRKGRQVRLPVRFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TRB4</accession>
    <name>A0A433TRB4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_008182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000219">
        <property type="protein sequence ID" value="RUS84070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TRB4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS84070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="260" mass="28631" checksum="4D2C3BD40C6B3F4E" modified="2019-05-08" version="1">MELQARLLGYFLCSPGAIRPRFGATNATTGNCSLVTWFQTHRAGLRCKASELVRLLNDASYTIIPRGVIEISPGGTKNATNGKYIPLLTWIYQDGMTNATMGTFSLIPCFPPNGTTSATTGIFPLLTWCYQTKIWSYKRHNGKLFSRHLVSDPLGRPVVQGFRACAPSNGGWCLKKQVGQSDSGGGDDDDDDDDDDDNDDDDDGGDDDDDNNDDDDDNDDDDDDDENDVPYLIVTAVLIFLVYIYYIGAQLDKTLKLKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TS03</accession>
    <name>A0A433TS03_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_007897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000208">
        <property type="protein sequence ID" value="RUS84365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TS03"/>
    <dbReference type="OrthoDB" id="10679378at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS84365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="419" mass="45394" checksum="CE2B7E8D7F9A7A54" modified="2019-05-08" version="1" fragment="single">KGIPESTAVEKRDRSPPSGQAGGDNLQGSWSERAFAASRLAGQGSGSDRGTFRTPDASPRVAAKSRDLQVSWSERRLASPLSLEEQEQQEEEEEEGGSAHWKLPRDTRRFRRKADVEREQRKESDKEEEEVVEKLRDTQNDVSREEPRDQSSVEFSDARPLSAERDSETRGEGSAQPACPLEVSSSTLKAMRIEGQTRTDADSRLSGGFEPSLEALETDQQEEELKSGGDKSGSCTGTFAGQVDGERKSSPPLTETKFNGSSNTDTCGEEKDGNRDGEGITGKDSGFDPMDGEKDEDCGEETNKSVGANGVHKYQTLLIVIRDLLVDYLTGMAQVPDEQDGGAPIVTATMKYLDQQCSRTELGALARCVGDGLGLDLPEDSASAREGQVALQRLLGLCDRFRALHLMSVLRGGVANGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TUA2</accession>
    <name>A0A433TUA2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_007124</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000181">
        <property type="protein sequence ID" value="RUS85119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TUA2"/>
    <dbReference type="OrthoDB" id="10044919at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="349"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="160"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="164"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS85119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="400" mass="44959" checksum="320A4B017B1B23C2" modified="2019-05-08" version="1">MNIVLTRLLLKSLELLSRDDDKYVTRKLTLGLLVLVWVISAAVAAGPLVGWGRYGYDAKTHYCGYDRTASISYTILIAAGTIGAPAMAVCYFNYSIFSFVREARRTLNKWRKDANTEDEKKSSVDGSPPRLNNHVMQTCLAKAACRNKCREDEEMRTYLEEKSTNISSSTPETSISTGSDPQSRSAERPKRRKKQISSRSMSQRPGSLKLKRQKDRKSRQRAEPQKHSNSYIIFPRFRSRGSRAQFSPSITNSVDSKDSTRSPCALRTSSNERILELLPQGSASQLLPPAENLGTNGTITPMRQNCSQPLGIKNLDMIRTLFVVFVCMAVFMSPYMVTTMADVHDRWSALVHCACSYLAVVNNAINWMLYGMLNSSFRAGYRKVMLDLCARRGRVLQTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TVG1</accession>
    <name>A0A433TVG1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_006696</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000166">
        <property type="protein sequence ID" value="RUS85553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TVG1"/>
    <dbReference type="STRING" id="188477.A0A433TVG1"/>
    <dbReference type="OrthoDB" id="424572at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04197">
        <property type="entry name" value="eIF-2B_epsilon_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11558">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000066">
        <property type="entry name" value="Translation initiation factor eIF-2B subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035543">
        <property type="entry name" value="eIF-2B_epsilon_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051956">
        <property type="entry name" value="eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044123">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="10">
        <location>
            <begin position="561"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="438"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="505"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="442"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="505"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="535"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS85553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="748" mass="83202" checksum="D21AAAAD3571FAAC" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TWP9</accession>
    <name>A0A433TWP9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-terminal amino-acid N(alpha)-acetyltransferase NatA</fullName>
            <ecNumber evidence="4">2.3.1.255</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_006233</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-alanyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-alanyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50500"/>
            <dbReference type="Rhea" id="RHEA-COMP:12701"/>
            <dbReference type="Rhea" id="RHEA-COMP:12702"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64718"/>
            <dbReference type="ChEBI" id="CHEBI:83683"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-cysteinyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-cysteinyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50512"/>
            <dbReference type="Rhea" id="RHEA-COMP:12707"/>
            <dbReference type="Rhea" id="RHEA-COMP:12708"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:65250"/>
            <dbReference type="ChEBI" id="CHEBI:133372"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N-terminal L-seryl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50504"/>
            <dbReference type="Rhea" id="RHEA-COMP:12703"/>
            <dbReference type="Rhea" id="RHEA-COMP:12704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-threonyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-threonyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50516"/>
            <dbReference type="Rhea" id="RHEA-COMP:12709"/>
            <dbReference type="Rhea" id="RHEA-COMP:12710"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64739"/>
            <dbReference type="ChEBI" id="CHEBI:133375"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-terminal L-valyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-valyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50508"/>
            <dbReference type="Rhea" id="RHEA-COMP:12705"/>
            <dbReference type="Rhea" id="RHEA-COMP:12706"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64741"/>
            <dbReference type="ChEBI" id="CHEBI:133371"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N-terminal glycyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetylglycyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50496"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133369"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. ARD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.255" evidence="4"/>
    <dbReference type="EMBL" id="RQTK01000153">
        <property type="protein sequence ID" value="RUS86021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TWP9"/>
    <dbReference type="STRING" id="188477.A0A433TWP9"/>
    <dbReference type="OrthoDB" id="25586at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990190">
        <property type="term" value="F:protein-N-terminal-glutamate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000101">
        <property type="entry name" value="N-alpha-acetyltransferase 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045047">
        <property type="entry name" value="Ard1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091:SF4">
        <property type="entry name" value="N-TERMINAL AMINO-ACID N(ALPHA)-ACETYLTRANSFERASE NATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="11">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS86021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="182" mass="20976" checksum="DBD93047E9698A1E" modified="2019-05-08" version="1">MNIRCATPNDLMNMQHCNLLCLPENYQMKYYFYHGLSWPQLSYVAEDHGGTIVGYVLAKMEEDPEDSVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMVENFKAQYVSLHVRKSNRAALHLYTETLKFSISEIEPKYYADGEDAYAMRRDLSEFREKCEADAEIPAIKGIFEAKEPIKQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TX56</accession>
    <name>A0A433TX56_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_006078</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000148">
        <property type="protein sequence ID" value="RUS86184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TX56"/>
    <dbReference type="OrthoDB" id="6157771at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF44">
        <property type="entry name" value="ZINC FINGER PROTEIN 271-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="848"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="876"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="219"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="327"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="612"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="350"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="385"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="641"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS86184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="981" mass="108382" checksum="AFDEF19689EEFC13" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TY34</accession>
    <name>A0A433TY34_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_005741</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000137">
        <property type="protein sequence ID" value="RUS86491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TY34"/>
    <dbReference type="OrthoDB" id="6158851at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008506">
        <property type="term" value="F:sucrose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF35">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 45 MEMBER 3 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="493"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="565"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="597"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS86491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="618" mass="67313" checksum="15434C83C60BC872" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U0G0</accession>
    <name>A0A433U0G0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Formin GTPase-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_004970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000115">
        <property type="protein sequence ID" value="RUS87290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U0G0"/>
    <dbReference type="STRING" id="188477.A0A433U0G0"/>
    <dbReference type="OrthoDB" id="1104827at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.40">
        <property type="entry name" value="Formin, diaphanous GTPase-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044933">
        <property type="entry name" value="DIA_GBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formin GTPase-binding" evidence="2">
        <location>
            <begin position="60"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS87290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="156" mass="17600" checksum="4E540668BA8F4306" modified="2019-05-08" version="1" fragment="single">MDKKDKDKNRNSFLDKVGGTFKVGSKTKKKSTSSANNKGPQIDENDSSDPFTESVDFDSMETAEVNERFEQLLDDMNLTEPKKAPLRSKDLKFRRQMLSMHSRGASKARRGELDTPHAFVQELMNADLKGQKRTQVLESLKVSLTSKPVSWAVEFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U312</accession>
    <name>A0A433U312_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EGW08_004049</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">EC2010</strain>
            <tissue evidence="17">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="EMBL" id="RQTK01000090">
        <property type="protein sequence ID" value="RUS88217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U312"/>
    <dbReference type="STRING" id="188477.A0A433U312"/>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000062">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057598">
        <property type="entry name" value="Fn3_PTPRU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF562">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23144">
        <property type="entry name" value="Fn3_PTPRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="18"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="14">
        <location>
            <begin position="395"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="15">
        <location>
            <begin position="568"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="14">
        <location>
            <begin position="680"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RUS88217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="852" mass="97675" checksum="9FC5849E94A95EB4" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U5Q7</accession>
    <name>A0A433U5Q7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Symplekin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_003086</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000064">
        <property type="protein sequence ID" value="RUS89143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A433U5Q7"/>
    <dbReference type="OrthoDB" id="331600at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021850">
        <property type="entry name" value="Symplekin/Pta1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032460">
        <property type="entry name" value="Symplekin/Pta1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022075">
        <property type="entry name" value="Symplekin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245:SF20">
        <property type="entry name" value="SYMPLEKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245">
        <property type="entry name" value="SYMPLEKIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11935">
        <property type="entry name" value="SYMPK_PTA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12295">
        <property type="entry name" value="Symplekin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Symplekin/Pta1 N-terminal" evidence="5">
        <location>
            <begin position="155"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Symplekin C-terminal" evidence="6">
        <location>
            <begin position="901"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="369"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1125"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1162"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1185"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1441"/>
            <end position="1459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS89143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1459" mass="164894" checksum="81858513A4A4B502" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U603</accession>
    <name>A0A433U603_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_003005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000061">
        <property type="protein sequence ID" value="RUS89262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U603"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS89262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="100" mass="11517" checksum="7971E3320A2F438A" modified="2019-05-08" version="1" fragment="single">MSQVKQRTVWSASLSQVKQRIVWSVSLLRVERGTVWSASLSQVKQWTAWSASLSQVKQRTVWSASLSQVKQRTVWSASLSQVKQRTVWSASLLRVERWTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U6G7</accession>
    <name>A0A433U6G7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_002809</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000056">
        <property type="protein sequence ID" value="RUS89436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U6G7"/>
    <dbReference type="STRING" id="188477.A0A433U6G7"/>
    <dbReference type="OrthoDB" id="5981855at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="155"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="492"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="639"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="643"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="673"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS89436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="742" mass="82319" checksum="228AD47343576029" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U751</accession>
    <name>A0A433U751_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_002563</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000050">
        <property type="protein sequence ID" value="RUS89642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U751"/>
    <dbReference type="STRING" id="188477.A0A433U751"/>
    <dbReference type="OrthoDB" id="432528at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46228">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46228:SF2">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_4G14350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS89642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="472" mass="53821" checksum="856E92AF95FAC588" modified="2019-05-08" version="1">MNKNVSMKPLTSLQSWVSCKILPDNNEGPITPDAIYCPGRVGHVAVCIRDELFVWGGYYQNEQWGTVYCKKAEVWVYSLDRDRWSRYFPRGAGSRHSSGSCSTMVWPYWYVLCGYLARGYTNIIWRLNMLTCTFESVRPQGDAISPRDKTVAWALDSRIFVLGGYGSVPLMCHIWDAEEDIYVREPMIEEDRGWLDQLAAFDTLTQTWALVETRGVSPLPRAAHSAVRVDMAVYIFGGRLAGVRMSDLHRLDLQSFTWSGALACNGDGPEGRSWHTMTRINEKNVILMGGYSDSNEILDDLWMLNVESLTWSLLQQHTQMPRLWHTACTNSMGDLLIFGGCTNNILDIASPMESSGDVLTVRLEPYSLERLSMHVLWKSRPGSWASWRSLPRNFRNWLEQREKAGWEMNRMIYRCQAYSMYGPSLTQLSVLQPGQADLINKSIVDIVELELEKQKDSQDKSTVDDSGIPYVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U7E2</accession>
    <name>A0A433U7E2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_002462</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:36684"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="RQTK01000048">
        <property type="protein sequence ID" value="RUS89759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U7E2"/>
    <dbReference type="STRING" id="188477.A0A433U7E2"/>
    <dbReference type="OrthoDB" id="4096362at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12349">
        <property type="entry name" value="ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12349:SF2">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="45"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS89759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="243" mass="27520" checksum="F6169131D0A58821" modified="2019-05-08" version="1" fragment="single">MMLNLCLSTFMDPGIFPRAPDDEAKDDDFRSPLYKTIDIKGVSTRMKWCTTCQFYRPPRSSHCSSCDTCIDTFDHHCPWLNNCIGRRNYRYFFTFLLSLCVHIVTIFAQCAVYAIHHNSNLLRPGPIISIVIMVVIGIIIVPVFGLTGFHMFLVAKGTTTNEQVTGKFKGGPNPFTRGCVKNCCYVFYGPRWPKLMGYIPRTKTVKLDSSKITYTAAGNNVSINQGNNSNGIRTINKNHNWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U9H4</accession>
    <name>A0A433U9H4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_001793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000032">
        <property type="protein sequence ID" value="RUS90452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U9H4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS90452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="33878" checksum="273ADAD4ED80C406" modified="2019-05-08" version="1">MLRLASVLLGQVIPGSTTLSYDTVDPRLVYLGVAVHLHHTFKTQSTMAEAAQFLFGCKAVMTSMAMAGRQSAAHAPSAPAPASVELQLILELLRSLNERMERLERQGSWQPGQTERPKDLLRRRRRTKGRSQMRCRRCRQPGNFARECRTPAPIGSTGRVVRGKAELGGKGVPVLADMGVEMSTVRQELGVDPGSSSSTIRPPTLPDRPVAPEPTVLPPERTVRSVNVVPSVASESRRRTPQLPEVNRNVPPRPMLSSQGQTLQIVNEVSPVVSRPRRRPMHLPQRRQDAKPIAFQPVVLSKDWSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UA29</accession>
    <name>A0A433UA29_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SUMO-activating enzyme subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ubiquitin-like 1-activating enzyme E1A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_001552</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of SAE1 and UBA2/SAE2. The heterodimer corresponds to the two domains that are encoded on a single polypeptide chain in ubiquitin-activating enzyme E1. Interacts with UBE2I.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000027">
        <property type="protein sequence ID" value="RUS90652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UA29"/>
    <dbReference type="STRING" id="188477.A0A433UA29"/>
    <dbReference type="OrthoDB" id="412647at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01492">
        <property type="entry name" value="Aos1_SUMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000744">
        <property type="entry name" value="Smt3 activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF162">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="9">
        <location>
            <begin position="18"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS90652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="336" mass="37688" checksum="1DD253102F5D0604" modified="2019-05-08" version="1">MEVGDNMETITEDEAELYDRQIRLWGLDAQRRLRAASILLIGLKGLGAEIAKNIILSGVKAVTLMDPNNIDEEDKMSQFFVSNAPIGQNRAVASAAPAQLLNPMVKVTADASDPSNKADDFFAQFDVICATGCKNSLQCRLDNLCQEKKIKFFSGDIFGFYGFMFSDLGRHEYLHEEIKKRKKDDDDKEDEGVTVTREVSNFSRLEDELKFDWTADTPGMKKKIRQTPSAFFITRVYEEFLELHGRRPSVATMEVDSKELQNLRILILNKLGVPAKCIPEDFYKYGFGELSPVCAIVGGVLGQEIIKAVSQKDAPLNNFFLFNGINDEGMVDKISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UAB9</accession>
    <name>A0A433UAB9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_001462</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000025">
        <property type="protein sequence ID" value="RUS90751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UAB9"/>
    <dbReference type="OrthoDB" id="431034at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS90751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="20478" checksum="DD1556341652272B" modified="2019-05-08" version="1" fragment="single">TNHSYTWLNNYLHLELQSTSRGGSKGFWIYYEAYPPLATTIEAPDTSNREDSSIDVDIPRGSNDWELSQPHQTDSMKLAGDSRAQTGDQNGESTPGKGGNPGSTVPLYRDDNKDSGKKLPFAAIAGGVIGTLSLILLVLLLLLFIKWCKERRYHKAEKILEIRNPAFRSSNDFHDTQGHAGYYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UAL9</accession>
    <name>A0A433UAL9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">PDZ and LIM domain protein Zasp</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_001451</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000024">
        <property type="protein sequence ID" value="RUS90832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UAL9"/>
    <dbReference type="STRING" id="188477.A0A433UAL9"/>
    <dbReference type="OrthoDB" id="1293114at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031941">
        <property type="term" value="C:filamentous actin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051371">
        <property type="term" value="F:muscle alpha-actinin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061061">
        <property type="term" value="P:muscle structure development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23068">
        <property type="entry name" value="PDZ_ZASP52-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000055">
        <property type="entry name" value="PDZ and LIM domain protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031847">
        <property type="entry name" value="PDLI1-4/Zasp-like_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050604">
        <property type="entry name" value="PDZ-LIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006643">
        <property type="entry name" value="Zasp-like_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214">
        <property type="entry name" value="PDZ AND LIM DOMAIN PROTEIN ZASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214:SF38">
        <property type="entry name" value="PDZ AND LIM DOMAIN PROTEIN ZASP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15936">
        <property type="entry name" value="DUF4749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00735">
        <property type="entry name" value="ZM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0440">LIM domain</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PDZ" evidence="8">
        <location>
            <begin position="13"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="240"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS90832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="33700" checksum="9CB72D873B505D8B" modified="2019-05-08" version="1">MSNIEYKPAEKLQIQLSRPDSKFPWGFRLQGGIDFSTPLSIQSVNPNSVSEQCGLKPGDAILAINNMTSDAMTHDDAKEVIMRSGNHITMLVERGAVKIWKPQVTPLNELRPQELRTITAATGDDVTPVQKTSLAINKPPDAPCTIGSSHNRSAQPFGKPKAAVPNVVHAQYNSPMGLYSANNIADTFAKQTVGIQKEMENVALYQLIHTVPCALLSGGFKSVSAPIAKPPSERPQQPSMRCGGCDMLATGVIVKASGVPYHVACFKCESCSMNLKQKGFFLVEGKLYCETHARRHAKPPGPDMVAVATYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UDH9</accession>
    <name>A0A433UDH9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_000427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000005">
        <property type="protein sequence ID" value="RUS91856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UDH9"/>
    <dbReference type="OrthoDB" id="6115351at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013879">
        <property type="entry name" value="DUF1761"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08570">
        <property type="entry name" value="DUF1761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS91856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="129" mass="14050" checksum="4A3157779DD07420" modified="2019-05-08" version="1">MIGCVVAVISNFIIGALYYHPKSPSGRVWLKRVFPDKSVNDIENSAAVGVTIVVNIMLVLLLRFILIDTFHAVNAVDGLKLGVGLWCLTSMLGFPPVLFAHRSVDVYVIEQVHNVISMAVSGVCIVSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z208</accession>
    <name>A0A3S0Z208_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">L-serine ammonia-lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_023215</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001861">
        <property type="protein sequence ID" value="RUS69022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z208"/>
    <dbReference type="STRING" id="188477.A0A3S0Z208"/>
    <dbReference type="OrthoDB" id="192663at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051318">
        <property type="entry name" value="Fe-S_L-Ser"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004644">
        <property type="entry name" value="Fe-S_L-Ser_mono"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005130">
        <property type="entry name" value="Ser_deHydtase-like_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005131">
        <property type="entry name" value="Ser_deHydtase_bsu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00720">
        <property type="entry name" value="sda_mono"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30182">
        <property type="entry name" value="L-SERINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30182:SF1">
        <property type="entry name" value="L-SERINE DEHYDRATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03313">
        <property type="entry name" value="SDH_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03315">
        <property type="entry name" value="SDH_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="Serine metabolism enzymes domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine dehydratase beta chain" evidence="10">
        <location>
            <begin position="2"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Serine dehydratase-like alpha subunit" evidence="9">
        <location>
            <begin position="124"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS69022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="43018" checksum="797258080EC319C1" modified="2019-04-10" version="1" fragment="single">YASILGVMGFSPETIDIDLANKLYDNLLKTNKITLVNKYKINFDPTKDVVFNNKVFLPEHPNGMILRLYNGDTPLVSEKYFSIGGGFIKNENNIKNGSDNDSNTTIKKPYEFSSAKELFDMCAKNNLTIADVMYENEKTAYTESEILAKIMEIWEVMDTSITKGLESDQAILDGGLGTRRRAPKLYKKLVNSNIASSDYNYLNIYAMAVNEQNASGGKVVTAPTNGAAGIVPAVFKYYLVSNNITDTKEIEKLATKYFLTNAAIGLLYKSRASISGAEVGCQGEVGVACSMAAAGYCSLIGGDNESVETAAEIAMEHNLGLTCYPVGGLVQVPCIERNAMAAVQSINAAKLAYLDSGEKHIVGLDSVIDTMYQTGLDMNSKYRETSLGGLAVSVPLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z6X8</accession>
    <name>A0A3S0Z6X8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_023847</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01004232">
        <property type="protein sequence ID" value="RUS68391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z6X8"/>
    <dbReference type="OrthoDB" id="6077660at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS68391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="137" mass="15244" checksum="005F266808FF63CF" modified="2019-04-10" version="1">MEVLLGVVDGGKLVKTAVFKGDHTSYMNWFSESHYINSSWPDLKGQHTHTYSIKGDEGHGRRFFINHNYNGCSNDAGWLVVVDSLTAGSCAWEKDESFPVIKYAAAENFENWSTGNIRNAQALVMFVKYSSAESIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z748</accession>
    <name>A0A3S0Z748_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane protein 33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_020115</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PER33/POM33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001108">
        <property type="protein sequence ID" value="RUS72128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z748"/>
    <dbReference type="STRING" id="188477.A0A3S0Z748"/>
    <dbReference type="OrthoDB" id="5581259at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071786">
        <property type="term" value="P:endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051645">
        <property type="entry name" value="PER33/POM33_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005344">
        <property type="entry name" value="TMEM33/Pom33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03661">
        <property type="entry name" value="TMEM33_Pom33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS72128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="30224" checksum="816A0FC38514FA4C" modified="2019-04-10" version="1">MSDSSENRQSSNIPPTDGSGDGQAPSQGSPLMAHLMQNKVETTLWLTRIFTVVCAIMFMLPIFGGNPYSFYQRTLLATAATSALRMHQRMPHVQLNMDFLRLLFTEDSCHYLMYCIIFLNSYPMTMSLIPCFLFALLHACSFTKTVLNLMGPTSLMFVRNMITKLEAQQVNILRFIASTEIFLMPAAVILVFTGKSSFFLPFLYYRFLSLRYTSRRNPYNRIIFSEFRQVTEYLCSKPQCPGLVRTLSFKCISIISRLAPVAQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z9P7</accession>
    <name>A0A3S0Z9P7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_019534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001030">
        <property type="protein sequence ID" value="RUS72698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z9P7"/>
    <dbReference type="STRING" id="188477.A0A3S0Z9P7"/>
    <dbReference type="OrthoDB" id="166212at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23011">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23011:SF28">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="60"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS72698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="209" mass="23848" checksum="2B1435576A59BDC5" modified="2019-04-10" version="1">MDEYGAKISFRGLTFRRKDFRANDQHSLSRGARRLLQQEPRTRTERDINLLLVALRHIPAFAEYPRKMQWRLCQVGRFEAYEPRRVVLKEGDVPTSFYFILSGTVIVTAFEEATQTSRTLVSLTKGMSFGEFKEIFMAGGRDILASEKQREFIKAAAKPLHQSRFWLVLFSSAHEVYTSGFYGCFAAKSASDRQPCDYLGGSTPCDVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZAC8</accession>
    <name>A0A3S0ZAC8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_017859</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000836">
        <property type="protein sequence ID" value="RUS74378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZAC8"/>
    <dbReference type="STRING" id="188477.A0A3S0ZAC8"/>
    <dbReference type="OrthoDB" id="6084619at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070593">
        <property type="term" value="P:dendrite self-avoidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000005">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF100">
        <property type="entry name" value="FASCICLIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="10"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="103"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS74378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="153" mass="17288" checksum="350A8E5651FE907A" modified="2019-04-10" version="1" fragment="single">CLFTSEEAPPGKAYVTPNGAKATLNKEFLLECFFSGKPIPTISWKNSSNHVITRGDPLYELDEFSRTLTIKNVRQEDEGTFQCTSENYLATEEATIKVNVTTPPLRTSESLRNYISPDKRDFTLTCKAKAALGERLEPPTWYRNGEVLTENYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZFF1</accession>
    <name>A0A3S0ZFF1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">POPDC1-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EGW08_014616</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">EC2010</strain>
            <tissue evidence="17">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell junction</location>
            <location evidence="3">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lateral cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the popeye family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000566">
        <property type="protein sequence ID" value="RUS77616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZFF1"/>
    <dbReference type="STRING" id="188477.A0A3S0ZFF1"/>
    <dbReference type="OrthoDB" id="425611at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016328">
        <property type="term" value="C:lateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051146">
        <property type="term" value="P:striated muscle cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006916">
        <property type="entry name" value="POPDC1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055272">
        <property type="entry name" value="POPDC1-3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12101:SF17">
        <property type="entry name" value="BLOOD VESSEL EPICARDIAL SUBSTANCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12101">
        <property type="entry name" value="POPEYE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04831">
        <property type="entry name" value="POPDC1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="10" id="KW-0965">Cell junction</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0796">Tight junction</keyword>
    <keyword evidence="8 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="POPDC1-3" evidence="16">
        <location>
            <begin position="84"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="28"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="363"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RUS77616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="420" mass="45579" checksum="E4AFC2CE8E27EBB8" modified="2019-04-10" version="1">MGEVVLFLESFTNLSKLGLRNSSHVIHPKHGVPGPGSGRGSVLSAPPFSSSSSSSSSSSSSSSSMSSVAEAGEWGVTCRDWQEAQHALFQLANLCAVISLLTPGSFRYHLLFLRCLLLVAFFLFVLWAGLFVCMVDVLIWNGIFLLVDLVHIVGLAYHNFPGKFSASLADFYTRRLKPLKVCSRDYSDMCTAGEVLPLRLGCHYAQEGFTESGRKLSVLLRGRLKVTVGEIFLHYVEANEFVDSPEFDAVPLETDPSQVLAGKYQVTITACEDCLILTWYRAALIEFLEYNPFLAAVLMNLIGKDVSDKLYRVQEQLIKESPSTGKVCSSHTSSLSGGRSCAVAGVASDMNACSTHAHEQSVPPRVACRQARHGQAGKSKRSSSNSSNNSNNSNSSNNSNSSTCSRCSRLGLELTVETTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZHH4</accession>
    <name>A0A3S0ZHH4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_017243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000779">
        <property type="protein sequence ID" value="RUS74994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZHH4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34999">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34999:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS74994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="324" mass="35445" checksum="5A27AE91B81718C9" modified="2019-04-10" version="1">MIRLDVACYNNVCPVLQQRLSCATPTSVLCYTDVCPVLHQRLSCATPTSVLCYTDVCPLLHQCLSCATPTSVLCYTNVCPVLHQCLSCATPTSVLCYTNVCPVLHQRLSCATPTSVLCYTNACPVLHQRMSCSTPTSVLCYTKVCPVVHQPLSCATTTYVLCYNNVFPVLQQRMSSATTTSVLCYTNVCLVLHQCLSCATPMSVLCYTNVCPVLHQCLSCATPTHVLCYTNVCPVLHQRMSSATPTSFLWYTNVCPVLQQRMSSATTTSVLCYNVCPLLQQHLSCATPTSVLCYSNVCHVLHQRLSCATLTYVLCITNVCPVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZJL7</accession>
    <name>A0A3S0ZJL7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_011800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000391">
        <property type="protein sequence ID" value="RUS80431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZJL7"/>
    <dbReference type="STRING" id="188477.A0A3S0ZJL7"/>
    <dbReference type="OrthoDB" id="3561125at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="285"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="314"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="345"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="401"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="429"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="485"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="540"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS80431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="572" mass="64383" checksum="AFB5FF09814BB5C4" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZTX7</accession>
    <name>A0A3S0ZTX7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein phosphatase 1 regulatory subunit 12B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Myosin phosphatase-targeting subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EGW08_017030</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">EC2010</strain>
            <tissue evidence="15">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, and one or several targeting or regulatory subunits. PPP1R12B mediates binding to myosin. Isoform 3 and isoform 4 bind PPP1R12A, but not isoform 1 of PPP1R12B itself. Binds IL16.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NRARP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000762">
        <property type="protein sequence ID" value="RUS75214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZTX7"/>
    <dbReference type="STRING" id="188477.A0A3S0ZTX7"/>
    <dbReference type="OrthoDB" id="19014at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019208">
        <property type="term" value="F:phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000004">
        <property type="entry name" value="Phosphatase 1 regulatory subunit 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000007">
        <property type="entry name" value="Phosphatase 1 regulatory subunit 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051226">
        <property type="entry name" value="PP1_Regulatory_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179:SF21">
        <property type="entry name" value="MYOSIN BINDING SUBUNIT, ISOFORM O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="77"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="110"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="203"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="236"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="359"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="319"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="411"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="436"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RUS75214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="527" mass="57045" checksum="739FA34CC6BD628D" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZU16</accession>
    <name>A0A3S0ZU16_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CP-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_006386</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000158">
        <property type="protein sequence ID" value="RUS85834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZU16"/>
    <dbReference type="STRING" id="188477.A0A3S0ZU16"/>
    <dbReference type="OrthoDB" id="269151at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1580.10:FF:000004">
        <property type="entry name" value="Mitochondrial GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782:SF4">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="4">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS85834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="439" mass="48447" checksum="6ECFB130465A4985" modified="2019-04-10" version="1">MQAKLKKIDCIVEIHDARIPFSGRNTRLKDFIKLRPHILLLNKVDLTDLNANKARRSGIEARLKLDGVDNVFFTSFHAMQNSSFLNSELLPLSKQLVESRPRYQREGADDFNMLVIGVPNVGKSTFINTLRNNQLYRKGKATTVGAKAGVTRSVLNKIKVGLNPPMYLIDTPGILPPNVSSLEAGMRLAACACVPDHIVGEVNIADYILYWLNSRENFQYVEYFGLTEASDNILDVLSKIAIDNRMVTKVKSVVTNTYVYRPDNVSSARMFLSAFREDAENLEQDTRDFDIHSILTPSHLERSKLDHAIVFNPIRGGRGSPASESDAGGPSFKPQRLRPTLVGSVSGSLRILQYCNRISKETVLWAFVYVGVLSIHVEALAAAHGMINKPGGGEVQDSCPGHGPHRDRVELGVYSEGSGVPKATWLARAETCQGGSTNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZVK8</accession>
    <name>A0A3S0ZVK8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating)</fullName>
            <ecNumber evidence="4">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_015928</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="4"/>
    <dbReference type="EMBL" id="RQTK01000673">
        <property type="protein sequence ID" value="RUS76304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZVK8"/>
    <dbReference type="STRING" id="188477.A0A3S0ZVK8"/>
    <dbReference type="OrthoDB" id="434986at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000002">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000007">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006113">
        <property type="entry name" value="6PGDH_Gnd/GntZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006184">
        <property type="entry name" value="6PGdom_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000109">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00461">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="198"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="14"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="37"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="79"/>
            <end position="81"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS76304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="436" mass="48531" checksum="DA15B0EB0A107E27" modified="2019-04-10" version="1">MFLSLTRGDIALIGLAVMGQNIILNMNDHGYTVVAFNRTVSKVEKFMANEAKGTNIIGATSLENMVSLLKKPRRVMLLVKAGAAVDAFIDSVVPLLEKGDIIIDGGNSEYTDTIRRVKSLKEKGIHYLGCGVSGGEEGARYGPSIMPGGAEEGWPSVKPIFQSISAKAGGEPCCDWRVHLILPYFLYYYYYHKITSYYLSLQVFNDWNNSELESFLIEITRDIMQYNDSDGAPLVEKILDSAGQKGTGKWTAISSLEYGVPVTLIGEAVFARCLSSLKDERMEASKQLQGPKKTKYDGDRKQFIEDIKMALYASKIVSYAQGFMLMRETAKELGWKLNFGSIALMWRGGCIIRSVFLGNIKQAYDKNPDLSNLLLDDFFKQEVQRCQDSWRKVVSQAVLMGIPTPAFSTALAFFDGYRSARVPANLIQVRLSIVQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZVS3</accession>
    <name>A0A3S0ZVS3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_005012</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000117">
        <property type="protein sequence ID" value="RUS87172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZVS3"/>
    <dbReference type="STRING" id="188477.A0A3S0ZVS3"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21245">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="36"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="150"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="208"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS87172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="244" mass="26736" checksum="CC0AA2EABD154B65" modified="2019-04-10" version="1" fragment="single">MSEKDTKSEINLLKHRDLHGGMQVPDDPYGESDDDKRLWFGNLDINMTEYAILKIVQKFGSIRKMDFIYHKAGPDKGKSKGYCFVSFHEWKTAEKTRKTLDGKFFFGRPIYVKWARSSKERDEFLMVNVKGSSGPLDAASATSSLALASSSSSSSSSKGAESQGPSVKGAEPLPGLSGGELEAASTSAKIQAIEAKLRLMEQTQKDFGVDATIKAPPGYVPLSTSQNKQGHGHHSSSRPTPYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZVT0</accession>
    <name>A0A3S0ZVT0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_004235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000095">
        <property type="protein sequence ID" value="RUS87957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZVT0"/>
    <dbReference type="STRING" id="188477.A0A3S0ZVT0"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS87957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="210" mass="23438" checksum="11C26EC801894FAD" modified="2019-04-10" version="1">MLYLLFKRYDLIAVAVDNGGGGDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDGGGGAVQHSPHCQRQQAQRHDGEPAHEVRDHHQVQLLSDGNVLLALVVAQLAMGVHILSLYVAHWPSPINKKSMKFSPTNMETEYCQPGSRSDRRGSPRHIPLLEYIPSPGRREGKAPLLRKLQTAGTQLLQLPLSDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZVU5</accession>
    <name>A0A3S0ZVU5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_005060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000117">
        <property type="protein sequence ID" value="RUS87220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZVU5"/>
    <dbReference type="OrthoDB" id="6062462at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF18">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="78"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="300"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS87220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="429" mass="47113" checksum="351B0ECD40D41431" modified="2019-04-10" version="1">MAENFIAIFLINTSAPNSEASTNASTAARAAHNGGSVGSGGAGVDVGAAGLVPYTSYSNIVLMTGSLNAVLCTLGIVANIVSLRTFLAMNGILQEGVTLTLFALTLSDLGLCVASLCWTVAATCYTVEHRLGVLHGRGFYLFSVDPRALGIYFVNVMSVFGVTTTLITTYLAVARCLCVLMPLRFRRAFSPARTVVVTSLFLLVVLATRLPLFALMDIRPRFDPRTNVTRWTRWYHPDRELVKDVLRSAVDIPLPVVAEVTLTFCVIVMVRALRASRKFRDVSCADVKISSSEQRRFKYKYTSDRNSAPTPASKPDDKGRETTNPAGNTAHGCKLSAKEFRVVKQLVIISCTYMVCNLPKLVRILADSVEPEFKLSGRYRNLYDIASHVQFMADTANSGVNLFIYLAFNARFREKCCLVHLFKLDAKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZY13</accession>
    <name>A0A3S0ZY13_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CNNM transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_014276</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ACDP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000540">
        <property type="protein sequence ID" value="RUS77967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZY13"/>
    <dbReference type="STRING" id="188477.A0A3S0ZY13"/>
    <dbReference type="OrthoDB" id="5353557at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008340">
        <property type="term" value="P:determination of adult lifespan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905941">
        <property type="term" value="P:positive regulation of gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040018">
        <property type="term" value="P:positive regulation of multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032026">
        <property type="term" value="P:response to magnesium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000006">
        <property type="entry name" value="DUF21 and CBS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF97">
        <property type="entry name" value="METAL TRANSPORTER CNNM-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="9">
        <location>
            <begin position="31"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS77967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="399" mass="44894" checksum="3103FBA3B5D56264" modified="2019-04-10" version="1">MDFVNCTIISEEKVLCDGKDYELPEAILTYKDEWFWIYIGIYVGLVLFAGLMSGLTMGLLSLDYTTLITMKEGGTPKERKYAARIIPLVKRHHLLLVTLLLSNAVAVEAMPIFLDHVSNPVIAIIVSVTAVLIFGEVVPQAVCTRYGLAIGAYLAPLVYFMMGAFFIIAYPFSKMLDWFLGTDHGTFYRRGQLKALIDIHGEESQTGGHSSLEDALSKDEVLIIKGCLDMRNKQAKDAMLNIEETFMLSINARLDHDTMTQVIEMGHSRIPVYESDRTNIVGCLLTKTLIKLDPDDAVPVSSLVCDTRYGRPPMFIESDQPLFDLLNTFQTGKSRLTIMIIFFFFLSLSVLKTIVGIITLEDVIEELLQEEIEDEVDITKEIAKKLHFSIARRKKSQVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZZW9</accession>
    <name>A0A3S0ZZW9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_013019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000463">
        <property type="protein sequence ID" value="RUS79234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZZW9"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS79234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="110" mass="12751" checksum="BE3352CC8973D81A" modified="2019-04-10" version="1" fragment="single">MSVKNCFLSQVKRLCQILIKSNHQVPSSLRKTQLVHLCRSCSTLLREQNHTVYQVQTRLKSSITRFRSENMAESKDGERQTEQLPSELFHTSVGQQEGWLVVGPYKVFAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A0D4</accession>
    <name>A0A3S1A0D4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_012736</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the patched family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000447">
        <property type="protein sequence ID" value="RUS79504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A0D4"/>
    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF130">
        <property type="entry name" value="PATCHED DOMAIN-CONTAINING PROTEIN 3-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="520"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="564"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="606"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="638"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="4">
        <location>
            <begin position="125"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="671"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS79504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="712" mass="77858" checksum="5C80F256444DD022" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A109</accession>
    <name>A0A3S1A109_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Defective in cullin neddylation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_001129</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000018">
        <property type="protein sequence ID" value="RUS91104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A109"/>
    <dbReference type="STRING" id="188477.A0A3S1A109"/>
    <dbReference type="OrthoDB" id="286637at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000436">
        <property type="term" value="P:positive regulation of protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000030">
        <property type="entry name" value="DCN1-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.200:FF:000001">
        <property type="entry name" value="DCN1-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF32">
        <property type="entry name" value="DCN1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DCUN1" evidence="5">
        <location>
            <begin position="60"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU410713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS91104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="259" mass="30495" checksum="34B93F46B0FACC86" modified="2019-04-10" version="1">MQRLKSSQKDKVRQFVAFTQTGEKTAINCLCAHEWKLDVAVDNYFIAPDRYNTAESRSSVDKRKIEALWQRYKDPGDEDKMLVDGVMQFLEDLQLNPESRTVLILAWRFKAKTQCEFTKEEFVQGMLEMGCDSVDKLRAKCNMLEHEIRDPNSFKDFYQFTFNYAKNPEQKGLDQEMAIAYWNIVLTGRFKFLDLWCKFLQENHKRSIPKDTWNLLLDFCNMINDDMSNYDEEGAWPVLIDDFVEYARPVVHGSRSTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A1P8</accession>
    <name>A0A3S1A1P8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Laminin EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_011812</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000391">
        <property type="protein sequence ID" value="RUS80443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A1P8"/>
    <dbReference type="STRING" id="188477.A0A3S1A1P8"/>
    <dbReference type="OrthoDB" id="6159857at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000051">
        <property type="entry name" value="Laminin subunit alpha 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050440">
        <property type="entry name" value="Laminin/Netrin_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574:SF444">
        <property type="entry name" value="BASEMENT MEMBRANE-SPECIFIC HEPARAN SULFATE PROTEOGLYCAN CORE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574">
        <property type="entry name" value="NETRIN/LAMININ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 6" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="9">
        <location>
            <begin position="2"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="9">
        <location>
            <begin position="105"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="234"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="254"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS80443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="281" mass="30798" checksum="63C9FF06014FB3E0" modified="2019-04-10" version="1" fragment="single">ECECEWPGTSGESLTCDTSPGAKYCTCDEGYEGMFCERCAPGFYRTAPHFPCHACPCNMHGANRTTCQYIEGFLKCDACEIGYEGTMCHRCSRGFYRYRKYCVPCHCNGNTPKDAHQMCLPSTGMCRSCQYNTTGFHCEFCLKGYVGSAKSFKKCVLPEDAVGLNMPGSADGLSEKSDSNTSGLSAGLIVTITMLVLLAIAAGGFLAFRRYRTWRRRKGPAFWTVGMSPSGDAVDISSVHNPDARLDDEDDDYRGDGVDGGDVREGRGKQSSKYLRLVEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AG78</accession>
    <name>A0A3S1AG78_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_001049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000017">
        <property type="protein sequence ID" value="RUS91136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AG78"/>
    <dbReference type="STRING" id="188477.A0A3S1AG78"/>
    <dbReference type="OrthoDB" id="419768at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010828">
        <property type="term" value="P:positive regulation of D-glucose transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090314">
        <property type="term" value="P:positive regulation of protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031340">
        <property type="term" value="P:positive regulation of vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08688">
        <property type="entry name" value="C2_KIAA0528-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037785">
        <property type="entry name" value="C2_C2CD5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038983">
        <property type="entry name" value="C2CD5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057815">
        <property type="entry name" value="C2CD5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056430">
        <property type="entry name" value="C2CD5_YbjQ-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056431">
        <property type="entry name" value="C2CD5_YbjQ-rel_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37412">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37412:SF2">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23025">
        <property type="entry name" value="YbjQ_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23028">
        <property type="entry name" value="YbjQ_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23128">
        <property type="entry name" value="YbjQ_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS91136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="937" mass="102935" checksum="19EEF2B52AFF4388" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AVP2</accession>
    <name>A0A3S1AVP2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_023687</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="RQTK01002361">
        <property type="protein sequence ID" value="RUS68551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AVP2"/>
    <dbReference type="STRING" id="188477.A0A3S1AVP2"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12198">
        <property type="entry name" value="MELK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.80:FF:000011">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="KA1" evidence="9">
        <location>
            <begin position="90"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS68551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="140" mass="15809" checksum="3E9177253ACC8947" modified="2019-04-10" version="1">MHMTTPVSGSKSGRKPGAVFGSIERMFNMLTPKRKGSLIDGPRKARALHNVCITNELSPDHVLAQLKTVLHKKCIPCQQSAYSLRCSVTDDWGRAKLAFDLEVCALPKNSFMGIHRKRVKGDLWHYKRLCEDILRSAKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AWY5</accession>
    <name>A0A3S1AWY5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_021793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001408">
        <property type="protein sequence ID" value="RUS70444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AWY5"/>
    <dbReference type="OrthoDB" id="8916439at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="51"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS70444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="122" mass="14472" checksum="A6E9FDA396F150D7" modified="2019-04-10" version="1" fragment="single">RFTSEVTLKNERDDLRIKYYDAKAECLDEHIKYTDERLARSMQEVAVPRRSQAETQEMLDLRTENTALKRELLELQQKKEEEAAALLEKYKREVGKRKALHNALVELRGNIRVYLRPKPLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AWZ5</accession>
    <name>A0A3S1AWZ5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_021781</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001405">
        <property type="protein sequence ID" value="RUS70457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AWZ5"/>
    <dbReference type="STRING" id="188477.A0A3S1AWZ5"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="AntiFam" id="ANF00263">
        <property type="entry name" value="Spurious protein deried from human HSATII repeats"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS70457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="830" mass="95890" checksum="4E342F874E4800A3" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AXN7</accession>
    <name>A0A3S1AXN7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_021242</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001290">
        <property type="protein sequence ID" value="RUS70992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AXN7"/>
    <dbReference type="OrthoDB" id="5807119at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS70992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="142" mass="16022" checksum="3B4B652367D86231" modified="2019-04-10" version="1">MDYLLANGKSAKKAGVSLTELSRKLFRTEGELARWQALRLAESYNRPQVQTGASQDPQSPIHQIRNNHHSLLDPTAASDADVTLAFVRDAFFHLLTDPIDREQHVRALLKIFAYPEPNLQRVKTGLADFKNIKLKKVFADAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B0J2</accession>
    <name>A0A3S1B0J2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase C1A papain C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_019076</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000970">
        <property type="protein sequence ID" value="RUS73167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B0J2"/>
    <dbReference type="STRING" id="188477.A0A3S1B0J2"/>
    <dbReference type="OrthoDB" id="190265at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="3">
        <location>
            <begin position="72"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS73167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="312" mass="33647" checksum="0885B6338EE388A8" modified="2019-04-10" version="1">MCRIFTVLARLSLSMVKRTPQSLNSSKFHPGRAELTRDIPGERPALAETTTGLAITRTKPRPYEDPAVMAALPRTWDWRNVSGVNYASPTRNQHIPVYCGSCWAMGSTSSIADRFNIARKGAWPSAYFSVQEVIDCAGAGSCGGGIPYGVFEYAHEQGIPDETCNNYQATYKLCTPETQCKTCAPNGSCHAIEGYKRWKVGDYGRVSGRDKMKAEIYNNGPISCGMVVTEAFVNYTGGVYREHSVPERLDHEVSVAQAGGSRVTWTQAWSTGLCGTRGARPGGRMAGSGSSPAATGTATGGCAWRKTALLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B1H4</accession>
    <name>A0A3S1B1H4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_018390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000894">
        <property type="protein sequence ID" value="RUS73846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B1H4"/>
    <dbReference type="OrthoDB" id="2020426at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS73846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="32757" checksum="A085CEB346E4D920" modified="2019-04-10" version="1">MISLGFEVKPSPSSGQAGLSHHVSGSSRTMSPTKRSNQGASPAKQQPKPQPKREVSIAEKARIINQLKREFPNSDPNVISIAATTCEFDMDKTKELIQAFEKKSDDHQDRHKGTRVSVTSSGPTSSPSSQPTQPSQQSLFPAGLSEEIPREGQSGTFSQHGPGHSKGSATVQGGTVSRSAQPQQARAQHVTSFYFRPKQKKTRQTAVVTSQPEPQRPAAECSNRTPTVGPNQELLRGPDSSLLSSEHIQAQGPNKALRVGPDLSRVAGPQGCKGADVTLSCGPQHGLLCHQQQDRVVTPSGILVSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B2G4</accession>
    <name>A0A3S1B2G4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_017777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000829">
        <property type="protein sequence ID" value="RUS74461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B2G4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS74461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="345" mass="37753" checksum="857BAD846BE0AF21" modified="2019-04-10" version="1">MQQKVQKTCIDRLNPKIAMSTESQDRQLELEKAVAVLEGCLAAEDAGGLQHPGVSPVKHLPLKKRHSFDFQPVTDTWADRPPVSAGFHLEQNNRSSERQIGLNSHVHLSKLESKTKSLSLARDQRSAQLLVGSSDDKLQGPQDHLTPKPTTYSQTEVQQEVRWSMGSLSSQACEASLSSEGWIMSPVFNACITRLVFCDSRGRRASGQVRRVRELELGARSTEQHLTIWRMRSGLWPWFGGTHGEGAEAAEQQGLTLMVPCANNHLDMMICVSSRKARQRLGAQTSGATGGITKTSAEPQGGGSCAGGRVLAFRPGGLISDIAHDDFTQYMTQEIVLPTVQISKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B3J6</accession>
    <name>A0A3S1B3J6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">IC97/Casc1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_018074</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNAI7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000859">
        <property type="protein sequence ID" value="RUS74159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B3J6"/>
    <dbReference type="STRING" id="188477.A0A3S1B3J6"/>
    <dbReference type="OrthoDB" id="297923at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031826">
        <property type="entry name" value="IC97/Casc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023247">
        <property type="entry name" value="IC97/Dnai7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20929:SF11">
        <property type="entry name" value="DYNEIN AXONEMAL INTERMEDIATE CHAIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20929">
        <property type="entry name" value="LUNG ADENOMA SUSCEPTIBILITY 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15927">
        <property type="entry name" value="Casc1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02043">
        <property type="entry name" value="CANCERSCCP1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IC97/Casc1 N-terminal" evidence="3">
        <location>
            <begin position="47"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="285"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="431"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="698"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="734"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="350"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="442"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="746"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS74159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="832" mass="95415" checksum="7AEC8A24395134A0" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B6Z7</accession>
    <name>A0A3S1B6Z7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Death domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_010942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000345">
        <property type="protein sequence ID" value="RUS81300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B6Z7"/>
    <dbReference type="OrthoDB" id="535509at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Death" evidence="1">
        <location>
            <begin position="88"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS81300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="163" mass="17910" checksum="1F0251F39DC3ACB8" modified="2019-04-10" version="1">MAAAASSAYDDIEEINDAGESAKPEVRSVILSDQNTGRPTVYVNSAKVVTSGDIHINNFGPKKSKKSKPLKPLTTCTEALSREQVIHISGKLGTRWKQLGRLLGFEDGALEQLELDNLGNSDERNYEMLKRWIDREGGHANQAQLAKHLAKAFMGKLADYLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BA71</accession>
    <name>A0A3S1BA71_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_016477</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000714">
        <property type="protein sequence ID" value="RUS75751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BA71"/>
    <dbReference type="STRING" id="188477.A0A3S1BA71"/>
    <dbReference type="OrthoDB" id="10264062at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF466">
        <property type="entry name" value="SI:DKEY-238D18.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS75751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="101" mass="12151" checksum="B1777103D11734EE" modified="2019-04-10" version="1" fragment="single">MREILLTFSAYHDQVGYAQGMNDILSRFLYVMGSEAETYWCFKTYMEKIRNDFMEEGLTRKIDLVRMLMKEMDPALLRHLEVVDLGNLFFCHRWLLLGFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BAM3</accession>
    <name>A0A3S1BAM3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U3 small nucleolar RNA-associated protein 11</fullName>
            <shortName evidence="5">U3 snoRNA-associated protein 11</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_016158</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the UTP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000688">
        <property type="protein sequence ID" value="RUS76084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BAM3"/>
    <dbReference type="STRING" id="188477.A0A3S1BAM3"/>
    <dbReference type="OrthoDB" id="29058at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007144">
        <property type="entry name" value="SSU_processome_Utp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03998">
        <property type="entry name" value="Utp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015952">
        <property type="entry name" value="U3snoRNP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR015952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS76084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="249" mass="29525" checksum="F0B39FA4AEA35C58" modified="2019-04-10" version="1">MSSWKKGKVQKVHRERPQPEARAHLGMLERKKDYRQRARAFHKKEETIKKLKRKAEDRNPDEFYFNMTRTKKVDGDHQLREASEPVVTEEQHKMMATQDKKYVLFRLSKELKKIEKLKKTLHLIDSSEKKNSHTIFVDDDNEAKSFDVAKFFDTHPAFLDRTFNRPTLESLKKGKFSVDPDELEAVMESKNIAYKELSKRIDRAKELKIIAEKLDAKLLGLDKKRKKKRVAEETKESAAQYKFAYQRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BDT5</accession>
    <name>A0A3S1BDT5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_013761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000507">
        <property type="protein sequence ID" value="RUS78473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BDT5"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="613"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="788"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="788"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS78473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="848" mass="92954" checksum="A56E0432116DEBFA" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BHG0</accession>
    <name>A0A3S1BHG0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DED domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_008198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000220">
        <property type="protein sequence ID" value="RUS84020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BHG0"/>
    <dbReference type="OrthoDB" id="6160190at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00045">
        <property type="entry name" value="DED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001875">
        <property type="entry name" value="DED_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48169:SF7">
        <property type="entry name" value="CASPASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48169">
        <property type="entry name" value="DED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01335">
        <property type="entry name" value="DED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50168">
        <property type="entry name" value="DED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DED" evidence="2">
        <location>
            <begin position="15"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS84020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="298" mass="34178" checksum="480F09872311F659" modified="2019-04-10" version="1">MATNLGQLVPSDDWELNLLLLKIAQQLDSSELENLKFLCSGSKGVPKRILSKFSTPEAFFTYLREQMMISRDNLLLLQAFMWHLQRKDLHELAADYARRIGNTLYFYAPSQEPEDGFKHVQFHVEGNLDRFQRSDLEALRATMARLLFVPQEFIFLSGVEPSSSLTLTFMIHEQYVDPLTELFRQHSDSFGKLGVDGMSVDDSEYMDPTLAVRRRASAPVGQATNEQLRVLYERSQQLQSQAEQSQIRSMEAQADAKLARQEALRYQQKGDYFRALVARILEDPDKPAPLDEHTLSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BIF8</accession>
    <name>A0A3S1BIF8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_007864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000207">
        <property type="protein sequence ID" value="RUS84402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BIF8"/>
    <dbReference type="STRING" id="188477.A0A3S1BIF8"/>
    <dbReference type="OrthoDB" id="10591010at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS84402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="421" mass="47039" checksum="CCC247017BC2FAB4" modified="2019-04-10" version="1">MPTAPSPPTATAKRRPLTAPSYGRRPVHAPGQASHKPDHASSSKYKYLKLNIVGSRLPLVTTREAQQPVGLKLPKLPETVSLSDRRLEEALDQTYLVNQPSLTPSGQLQVDGHHHSRLRRSEEELYTEVDDSKGHRREEELADVAAIRIDGRSTWKSKHVEVLSETEEEDISSTAPRTVEAEQPSVEEDGYVEDAGQESEKPQVLAEIAEEMERREETQEVEGDLETVPNVQEDAGVNQKEVGEENEFGVNQKEVGEENEEIAKEKDDEEEDQAEDNDEDNAREVDTDPEQTALETGEEEGQREETEEETDKVESEDEPDLEEATGDQVEMPKEDIDNEEEQEVQDEEIGDPAHSEGDEDVKVDENVKADDQDQDGVRFFITEDGVGNITKSGHDHPPHDGVKSEPAVEDENQDPENDGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BK42</accession>
    <name>A0A3S1BK42_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Polynucleotide 5'-hydroxyl-kinase NOL9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_009575</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Clp1 family. NOL9/GRC3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000276">
        <property type="protein sequence ID" value="RUS82672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BK42"/>
    <dbReference type="STRING" id="188477.A0A3S1BK42"/>
    <dbReference type="OrthoDB" id="2405412at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000448">
        <property type="term" value="P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057570">
        <property type="entry name" value="NOL9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057573">
        <property type="entry name" value="NOL9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF3">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-HYDROXYL-KINASE NOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24419">
        <property type="entry name" value="Cupin_NOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25467">
        <property type="entry name" value="NOL9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NOL9 N-terminal" evidence="12">
        <location>
            <begin position="285"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 P-loop" evidence="11">
        <location>
            <begin position="473"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="NOL9 C-terminal" evidence="13">
        <location>
            <begin position="691"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="216"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF24419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF25467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS82672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="843" mass="93433" checksum="40A6766C0E315BE7" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BLK5</accession>
    <name>A0A3S1BLK5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_022295</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001530">
        <property type="protein sequence ID" value="RUS69939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BLK5"/>
    <dbReference type="STRING" id="188477.A0A3S1BLK5"/>
    <dbReference type="OrthoDB" id="10051775at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4020.10">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003309">
        <property type="entry name" value="SCAN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038269">
        <property type="entry name" value="SCAN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888:SF1">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888">
        <property type="entry name" value="ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02023">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47353">
        <property type="entry name" value="Retrovirus capsid dimerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50804">
        <property type="entry name" value="SCAN_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SCAN box" evidence="4">
        <location>
            <begin position="186"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="322"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS69939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="50436" checksum="197A2F268AF10E67" modified="2019-04-10" version="1">MSSIQEIKELAEELQLRGDEKRKFIIEQMDKLRQLQAEKEEREAKLLREEREAKLQAEKELKMEEMRTQLELARIQAQASQQSEHNLTSGSTRSVHDEGEHSKFKMPKLPAFVDRKDDLDSWLLRFERFATTSGWPKESWCTPLSALLTGRALEAFCRLSETEATDYDRVKEVLQKRYNLTEDGYRQRFRTGSPEEGENPSMFIVRLKTYLERWMKLAEAPQTYEALRDLFVKEQFLDSSPADLSTYLRERRLADLEEVARSAELFLTARKRQLSDRARQGITREQNRPSSSKEEEIICHICRKPGHSTRNCRNKATHGRGCYHCGELTHVRKDCPKLRMNNSKKEGDNEIDPYVYRTKIKTADANTFPRMLKLNFRGNPRFRGQFPSHLTHVLPSLRLSTIPTPKSPVLSSSLCFLLLCQEHLLLTAREGDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BR25</accession>
    <name>A0A3S1BR25_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_002826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000057">
        <property type="protein sequence ID" value="RUS89389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BR25"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS89389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="193" mass="20794" checksum="F8DC6F4F93C85B8A" modified="2019-04-10" version="1">MDFSSFVKEEDGSKQPNVTLVKRFSSVEPKSPNSPLRTPSGLDNAYSLPEDDAVFKEEQQPPQRISSVESKSSISPLRSRSFHDNTYSLPDDDAVFTEPSPKENNNLGHMATPPPTPGTAPAASGHASNQRKPRLRHLACILVAVVVLTGLVASVALILVFVNKESSSPRSLPISASPRTVQGKNKIALDINP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BRG5</accession>
    <name>A0A3S1BRG5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_005309</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000124">
        <property type="protein sequence ID" value="RUS86904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BRG5"/>
    <dbReference type="STRING" id="188477.A0A3S1BRG5"/>
    <dbReference type="OrthoDB" id="10045365at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050969">
        <property type="entry name" value="Dev_Signal_Modulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013111">
        <property type="entry name" value="EGF_extracell"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14949:SF56">
        <property type="entry name" value="EGF-LIKE-DOMAIN, MULTIPLE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14949">
        <property type="entry name" value="EGF-LIKE-DOMAIN, MULTIPLE 7, 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07974">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="61"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS86904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="98" mass="10610" checksum="1FB8981060155116" modified="2019-04-10" version="1" fragment="single">CRRACQNGGQCVGLNRCHCPSGFQGRHCESPVCVPACLNAGTCLKPGLCACPPGYRGNRCQEAVCRPKCMNQGRCVGPNQCMCTSGWTGHRCDQREYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BT38</accession>
    <name>A0A3S1BT38_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_001307</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000022">
        <property type="protein sequence ID" value="RUS90910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BT38"/>
    <dbReference type="STRING" id="188477.A0A3S1BT38"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000532">
        <property type="entry name" value="SLC (SoLute Carrier) homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF399">
        <property type="entry name" value="FI19708P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018720022" description="Major facilitator superfamily (MFS) profile domain-containing protein" evidence="6">
        <location>
            <begin position="20"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS90910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="366" mass="39785" checksum="DF92C6F1EA499C41" modified="2019-04-10" version="1">MIMRIIAGLSQGVVWPAMAVLWTKWAPSLESGKLTGICYAGSQIGNVVTFPVASYLCEYGFDGGWPSVFYVLGSFGVLWFIGWMIIVADTPEQHPRISNAEREYICEDRKGNNAPEKEKPTAPTPWLAIMTSRHVWALIVTHTCANWGTYTFLTNIPSYMKEVLYFDLKKNGLLSALPYIGFGAIISISGALIDLVVSRGLLGKTAARKLGNTLGLLVPGVFVVGLAFVDCTQSTLAVVLLVIGVAMSGFQYGAGFLTNPAELAPHYAGVIFGISNTFATLSGIFAPIMIGYITTDQTQEQWQKVFFIAAAIYIFGALVFIFFGSAEVQPWDQVTLEVEVQVKASGEKTVVGDNALNKPEKEEHSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BTE5</accession>
    <name>A0A3S1BTE5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_001062</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000017">
        <property type="protein sequence ID" value="RUS91149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BTE5"/>
    <dbReference type="STRING" id="188477.A0A3S1BTE5"/>
    <dbReference type="OrthoDB" id="284854at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051984">
        <property type="entry name" value="Alsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059093">
        <property type="entry name" value="HA_Alsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46089">
        <property type="entry name" value="ALSIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46089:SF2">
        <property type="entry name" value="ALSIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26202">
        <property type="entry name" value="HA_Alsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="VPS9" evidence="3">
        <location>
            <begin position="396"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS91149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="541" mass="60234" checksum="1DC6E4C8F5ED1BF7" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BTY8</accession>
    <name>A0A3S1BTY8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_017410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000795">
        <property type="protein sequence ID" value="RUS74820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BTY8"/>
    <dbReference type="STRING" id="188477.A0A3S1BTY8"/>
    <dbReference type="OrthoDB" id="151490at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039340">
        <property type="entry name" value="Tfc4/TFIIIC-102/Sfc4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIIC TFIIIC , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS74820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="216" mass="25160" checksum="E0627024D9A83276" modified="2019-04-10" version="1" fragment="single">NVEFLCLKAGPVNDNVYHLVRNLVSDNTENHQAWNLYNYILTRMKGAGVDLRFTVRALMKNPNSIPLSILNGNERLISSTYTQAVAEYMDVFKKMPDNDMVILCSAISLLHIASNAHVVRKNNLILQITSLLNVYREMRGECQETYYNIGRAWNQMNIQFAAVHYYKKALEFPAAVIDDKGTFDLRREIAYNLSRIYMRSNNYDYARYYIERYCVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BU89</accession>
    <name>A0A3S1BU89_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_003399</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000072">
        <property type="protein sequence ID" value="RUS88854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BU89"/>
    <dbReference type="STRING" id="188477.A0A3S1BU89"/>
    <dbReference type="OrthoDB" id="5959154at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14981">
        <property type="entry name" value="7tmA_Prostanoid_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008365">
        <property type="entry name" value="Prostanoid_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11866">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR FAMILY 1 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11866:SF16">
        <property type="entry name" value="PROSTAGLANDIN E2 RECEPTOR EP4 SUBTYPE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01788">
        <property type="entry name" value="PROSTANOIDR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018719486" description="G-protein coupled receptors family 1 profile domain-containing protein" evidence="12">
        <location>
            <begin position="20"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="1"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="407"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="483"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="588"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="645"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="451"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="483"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="496"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="536"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="588"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="666"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="687"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS88854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="721" mass="78944" checksum="610BFFBB15559F0E" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BVR2</accession>
    <name>A0A3S1BVR2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_002355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000045">
        <property type="protein sequence ID" value="RUS89914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BVR2"/>
    <dbReference type="STRING" id="188477.A0A3S1BVR2"/>
    <dbReference type="OrthoDB" id="25503at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12908">
        <property type="entry name" value="SPRYD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035783">
        <property type="entry name" value="SPRYD3_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="1">
        <location>
            <begin position="50"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS89914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="488" mass="54576" checksum="985AA95F51506E8C" modified="2019-04-10" version="1">MAGLDQLQAILRYRRDAMQQLQQARGLGGRPPVPEGYNPHQLLFVNNQRRGLGVGRPPPDIANQILLNNPHVRRGQPAPPARVGPVLNHIKMEDDVLSYSSEAGDQIGLYIASHPIEHYENYFEIQILDVGDLGQIAIGLVPEKYPLNVQPGIEPNSVGYMTESGKIYLNHGRGMRDATQQGPACEMGDKIGVGVRLVDEHARPERRGRRVFFTKNGQEVKSVYLSARFGPLYPAVGMQSEGEEVSLRLDAVWNPDDVTQMLVDCGEEDWLRLEDIRLNGNMLEYTGRGHSIHDVGLAQAKHPLDTANHYFEFEIVDQGEKGFVAIGLARRNYPARRHPGWNHGSIAYHADDGKLFHGSGMGMHFGPKCSRGDIMGCGIYFPLDYDDEAENPDEDGDGDPGIPDYEILDDPINNLLWDSDDEDHPLMWPPIQRHHRRDVGKKVKVFFKRNGKLIGLREVNVPRGGFFPTVGMMSCNEKVRVDLHPLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BWP1</accession>
    <name>A0A3S1BWP1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ZP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_001667</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000029">
        <property type="protein sequence ID" value="RUS90579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BWP1"/>
    <dbReference type="STRING" id="188477.A0A3S1BWP1"/>
    <dbReference type="OrthoDB" id="10063988at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4100">
        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3210">
        <property type="entry name" value="Zona pellucida, ZP-N domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055355">
        <property type="entry name" value="ZP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042235">
        <property type="entry name" value="ZP-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14002:SF43">
        <property type="entry name" value="DELTA-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14002">
        <property type="entry name" value="ENDOGLIN/TGF-BETA RECEPTOR TYPE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00100">
        <property type="entry name" value="Zona_pellucida"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="ZP" evidence="4">
        <location>
            <begin position="60"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="20"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="275"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="275"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="345"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS90579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="439" mass="49877" checksum="BA5623BBFF3F7827" modified="2019-04-10" version="1">MPFIHPAFSPTPVPANVDCRLPQENGPSAPIPTPTNNGGRLLQDDVGPQQSPGQLQHDFDCHATNMLVHIPSSLAPNSKMYMRDKNCELTNNGTHFVLTLPYDSCGTALTFYTDYVFARNEVTVHLDIDPNAPVQFDSDYEIPLECKVPRDHRVDGAFVAVTRDPIVEAGGEVATAEFVLREFKSALYREEITEYPLVVPLNKEVFFEVDVENVHQVDVGVYVTWCDATPTPDADDPRAYRLIEDGCPASPAVHIEPVPSPDRFRFRSQSFHFSGEANNENQSTKSNNNNNNNNSNNNNNNCNNRQNSNSNNHYNDSNNHNNSNNQKNNSNNHYNNSKNHKNHNNHNNNSNNHFNNSNNNYNNSNNHNNNSNNYYNNSNNYFNNYFNNHYNNHNNNSNNHFNNSNNNYNNHYNNHNNNSNNHFNNSNNNYNSPAKHEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BX46</accession>
    <name>A0A3S1BX46_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_001283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000021">
        <property type="protein sequence ID" value="RUS90979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BX46"/>
    <dbReference type="OrthoDB" id="6161789at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS90979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="409" mass="46924" checksum="E46D54481310767A" modified="2019-04-10" version="1">MSLKENKIFFKENKLSLKDQKMFPQETKRSLKDNKNSVQDNKNTFQDNKMSFQAILNKSAKNSVISHVDTAKKGRPSLTRKGKKKTDQLFETAGSNQDKSSDKPTSLYSYKPSVEEYFAEGMERYRLELELEANEWSHLGSTEREQTPSSGLLGDVLDRQLCNLEMITRACQTDWKWLLMAVRWRHARIINSSLPQPPRAPTAIEYDLDATHVASAVSCKHHASGSQEHVSKILRIKRSKASSLGHQQHRHKDKCVDTRDLDFNAFDHKLRYTPTQTRMSTGKFLAHRSSSMIFRWKDIARSTIISQHRRRSLKTGSTSSSYSGRSTISVQSANDRPDSIVKDDILTPRSRSRSSSSEEEQERPARLRFTETVLVEEKGLRPGQEQGRKSSSQRKSRKESIIEYEKTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C172</accession>
    <name>A0A3S1C172_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_012062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000407">
        <property type="protein sequence ID" value="RUS80173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C172"/>
    <dbReference type="OrthoDB" id="10678716at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS80173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="330" mass="36414" checksum="5FB68BF611E2D43C" modified="2019-04-10" version="1">MFVNASSAEVCLRSLALAESARNNSTLAESTLGNLTLAESSALFNSSLASIILSRSNLSYLLNTAKSNVNLFPLTERFVFLRSMMNTDHCFQSMQSPAQEGGKEMGSTNVSLLQMRAKAFHRATMELLIHVISFESEASKATPLLLGLDHHKQLVKQLLDHLQDSLSEVYNMELKLAGMTEVIKTILTDNCAKKPTVLDTPTFEVEDADDPEDSTELPEHPEYMMSANTQFSESQSLPDANTALGEQHAAMTPASDHTIKELYSVNYDPEDSTELPEHPEYMMSANTQFSESQSLPDANTALGEQHAAMTPASDHTWTKELYSVNFHNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C3S9</accession>
    <name>A0A3S1C3S9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_010040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000298">
        <property type="protein sequence ID" value="RUS82200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C3S9"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS82200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="107" mass="11484" checksum="F4932E021C6C643F" modified="2019-04-10" version="1" fragment="single">DLDDLLRVPHGVLVLAVVALLALLAVQLKHHIARVGGRVQVEPEDHATLHGRPAHVTDLAGEPDLGTVLEDAPSLAGWHEGREQVPRVVGVLGEQAVKLPVPYQFHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-05-03" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1CDT1</accession>
    <name>A0A3S1CDT1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_002313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000044">
        <property type="protein sequence ID" value="RUS89961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1CDT1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018592665" evidence="1">
        <location>
            <begin position="20"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS89961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="212" mass="22050" checksum="C8A3EBA4511B40FE" modified="2019-04-10" version="1">MKLTLTLVYMAALVLCVQCMPGRFRRDANDIVAETARIAAKEDSDVSNFVASEQQALSDASSLVSQLQADSSDPAKLQADLAKIPAAANQASSAGENFQAQWEADVAAGDRLAAQVQQANLPPDAQAVANMADAIQSEAKANVQALSSGWADLQQEAAGLDNTVSAGQGSVQLDIKDAAQFVKDVQSGLDAFVNDMEGVRAKAKALVAEVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1CFF1</accession>
    <name>A0A3S1CFF1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_001046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000016">
        <property type="protein sequence ID" value="RUS91240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1CFF1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS91240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="110" mass="12614" checksum="279BA98EFABE1B9C" modified="2019-04-10" version="1">MVVESGQEERRFSLHRERFSKSEAFSLFGVTVSVMSTEELWSQQTRWFGFDRTSLQIRRISARSLSCGVSEKRQESMYDLVWDASSCTVLGISIRTNDRSVHSLDVRASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H1Q8</accession>
    <name>A0A3S1H1Q8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">SRCR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_021778</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001404">
        <property type="protein sequence ID" value="RUS70459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S1H1Q8"/>
    <dbReference type="OrthoDB" id="6153669at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000005">
        <property type="entry name" value="Neurotrypsin isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000016">
        <property type="entry name" value="Scavenger receptor cysteine-rich protein type 12"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000007">
        <property type="entry name" value="Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF18">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1311"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="13">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="13">
        <location>
            <begin position="96"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="13">
        <location>
            <begin position="208"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="13">
        <location>
            <begin position="319"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="13">
        <location>
            <begin position="426"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="13">
        <location>
            <begin position="562"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="13">
        <location>
            <begin position="654"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="13">
        <location>
            <begin position="769"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="13">
        <location>
            <begin position="883"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="13">
        <location>
            <begin position="992"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="13">
        <location>
            <begin position="1102"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1212"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1260"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1260"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="500"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="613"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="722"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="795"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="841"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="924"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="953"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="1060"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="1170"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS70459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1452" mass="157314" checksum="9E04D42BB54DDC68" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HRL8</accession>
    <name>A0A3S1HRL8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_007494</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000194">
        <property type="protein sequence ID" value="RUS84752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HRL8"/>
    <dbReference type="STRING" id="188477.A0A3S1HRL8"/>
    <dbReference type="OrthoDB" id="6152035at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="6">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS84752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="105" mass="11646" checksum="083FAE6D5BE2C6E2" modified="2019-04-10" version="1" fragment="single">PVTCPSASGQFAYTADCAKFYQCDNGVATVTNCQSQLVFNPQTGYCDWPANKVPQTEIRIPPEMFKPQFANLCTQNPYGGNPGETFLVRHPEYCNAFFTCTEGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HW44</accession>
    <name>A0A3S1HW44_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MD-2-related lipid-recognition domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_004964</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000115">
        <property type="protein sequence ID" value="RUS87284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HW44"/>
    <dbReference type="OrthoDB" id="6140224at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018786158" description="MD-2-related lipid-recognition domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="2">
        <location>
            <begin position="54"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS87284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="167" mass="18766" checksum="2747F3C896BAFE2B" modified="2019-04-10" version="1">MHFKQTSLLVSAVVLVTIGTAFCDSGAVLRFNPRNDGIGYATNCGQNPFNFSWSPKILSAQHSVDITFEYTFAYKLDGGFYNLTLREFGEAEPFLSHAYPFSCDDITKTVACPVSKGFSVNLKKTITNTKYLLSFPGRYILIVEIKNSERQQMLCARMDITINNNIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1I223</accession>
    <name>A0A3S1I223_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EGW08_001503</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">EC2010</strain>
            <tissue evidence="17">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TMTC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="5"/>
    <dbReference type="EMBL" id="RQTK01000026">
        <property type="protein sequence ID" value="RUS90699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1I223"/>
    <dbReference type="STRING" id="188477.A0A3S1I223"/>
    <dbReference type="OrthoDB" id="19588at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013618">
        <property type="entry name" value="TMTC_DUF1736"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052943">
        <property type="entry name" value="TMTC_O-mannosyl-trnsfr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44809">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44809:SF1">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE TMTC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08409">
        <property type="entry name" value="TMTC_DUF1736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="9 13" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018749356" description="dolichyl-phosphate-mannose--protein mannosyltransferase" evidence="15">
        <location>
            <begin position="20"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="265"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1736" evidence="16">
        <location>
            <begin position="276"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="451"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="516"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="584"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="759"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="793"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RUS90699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="844" mass="94090" checksum="BDA5F1084CA4D4A0" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SID0</accession>
    <name>A0A433SID0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA topoisomerase 2</fullName>
            <ecNumber evidence="10">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_023585</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16 10">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type II topoisomerase GyrB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the type II topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="10"/>
    <dbReference type="EMBL" id="RQTK01002137">
        <property type="protein sequence ID" value="RUS68653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SID0"/>
    <dbReference type="STRING" id="188477.A0A433SID0"/>
    <dbReference type="OrthoDB" id="276498at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00822">
        <property type="entry name" value="TopoII_Trans_DNA_gyrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000005">
        <property type="entry name" value="DNA gyrase subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.670:FF:000004">
        <property type="entry name" value="DNA gyrase subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002288">
        <property type="entry name" value="DNA_gyrase_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041423">
        <property type="entry name" value="GyrB_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000565">
        <property type="entry name" value="Topo_IIA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45866:SF1">
        <property type="entry name" value="DNA GYRASE SUBUNIT B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45866">
        <property type="entry name" value="DNA GYRASE/TOPOISOMERASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00986">
        <property type="entry name" value="DNA_gyraseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18053">
        <property type="entry name" value="GyrB_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01159">
        <property type="entry name" value="DNAGYRASEB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="DNA topoisomerase type IIA subunit B" evidence="11">
        <location>
            <begin position="64"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="DNA gyrase subunit B insert" evidence="13">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="DNA gyrase B subunit C-terminal" evidence="12">
        <location>
            <begin position="297"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS68653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="369" mass="40525" checksum="2A233C7CF0DE08F0" modified="2019-05-08" version="1">MVFEVVDNAIDEALAGHCDDIKVIINTDGSVSVSDNGRGIPTDIHKEEGRSAAEVIMTVLHAGVNGIKDDIQVELALQWNDTYKESIFCFTNNIPQRDGGTHLSGLKAAITRTMNSYIESEGLNKKLKVALTGDDSREGLAAVLSVKVPDPKFSSQTKDKLVSSDVKSAVESLVNEKLQEFLQENPRESKIICEKILDSAKAREAARKARDMTRRKGALDIAGLPGKLADCQEKDPAMSELYLVEGDSAGGSAKQARDRKTQAILPLKGAYVERGARKEYVDSFESAIDWLLSEARKGHDVQRYKGLGEMNPEQLWETTMDPENRILLQVTVADAVVADSLFTTLMGDDVEPRREFIESNALNVMNLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SJC4</accession>
    <name>A0A433SJC4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_023077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001802">
        <property type="protein sequence ID" value="RUS69162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SJC4"/>
    <dbReference type="STRING" id="188477.A0A433SJC4"/>
    <dbReference type="OrthoDB" id="6436361at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22961">
        <property type="entry name" value="DD_TEX55-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS69162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="141" mass="16793" checksum="F579DA7E46516AD8" modified="2019-05-08" version="1">MSVASREVAKQYLNQHKIPQLFESLLSSLMMERPNNPVEYIEKKMCQIRDLGIENVTWETLISHLHPYRDQIRRQFVRDGSLYDKEYTILQGEIEEFRQRKKDQFETMHSGVGFEDSNEDDCPMETQQYDSQLFQLTEAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SK33</accession>
    <name>A0A433SK33_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_022903</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001722">
        <property type="protein sequence ID" value="RUS69336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SK33"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS69336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="127" mass="14719" checksum="13EFEFE86E6B2201" modified="2019-05-08" version="1" fragment="single">NITWVLVQRVYRTTGEVLVQRIHRNIGEILVQRIHRNIGEILVQRIHRNIGEILVQRIHRNIAKTLVQIVHMAIVEVVVQMVHRDIAKILVQIVIRATVEVVVQIVHRNIANILVQVVHMNITDIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SKA4</accession>
    <name>A0A433SKA4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_022705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001651">
        <property type="protein sequence ID" value="RUS69532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SKA4"/>
    <dbReference type="STRING" id="188477.A0A433SKA4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS69532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="236" mass="23750" checksum="8EB703F555114C41" modified="2019-05-08" version="1" fragment="single">QPPNGLSGQTTLTSLAAAGGSSSFGGAATAGSSLFSAKTLSATPGTQGGGFTSSAAPAPAGFGSVGSAGTLSGGFSSTPQSSAFVTPASGQSPATPINLTARQPPAFPGLSKAGPPVSNSAPSPAGLFGADKAKPPQSNLSAFTLSKPAAPAQQTPADVTPGPPVESQKSIDARLDSAFTHNIIEEIRDFQEELRQLRSRAQGGIKSVGTREEMQRLKQDTEKMIHFSQEIKSVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SKL9</accession>
    <name>A0A433SKL9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_022605</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001618">
        <property type="protein sequence ID" value="RUS69631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SKL9"/>
    <dbReference type="STRING" id="188477.A0A433SKL9"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="4">
        <location>
            <begin position="39"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="9"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS69631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="201" mass="22243" checksum="42DB8E24AF1158F5" modified="2019-05-08" version="1" fragment="single">DCKYALLVATAQPESRRDHDEKHTGHEDKKEKEKEKEKRDREKDLVQAAVDGTVNVLGAIAENNPGIIRVVLTSSLSAVASHGGNSQPYSEFDWPHFDDPAVLPQTKAKVAAERAAWDFVKKLPHGKKFDLAVVNPAEMMGPVQHHHHGPATELLCQLLEKKVSSVPAFILPCVDVRDVARAHLVCMNNVNTIGQRHILYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SKP6</accession>
    <name>A0A433SKP6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_022536</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001601">
        <property type="protein sequence ID" value="RUS69700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SKP6"/>
    <dbReference type="OrthoDB" id="10441012at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS69700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="36210" checksum="72B6393AB50D78EB" modified="2019-05-08" version="1">MVIVRDREFIHKPYNILFLGLNSAIVMSTSFMDEIKIEMLKNLHRIIDGSNLLILRPTSIAITWYKDPADISNHFHWTNKISSLLIVQEVFVILAAVIAFVSLPFHRGYVVFTLYCLSLCAGMTLQVFFISSILEPSSRLYATMVRSAVSELENKYKLLTNSTYVSTVNSYMINARCCGVIGPHDFLHVNLSFSKTNFLFPYNPYRGADLYFPPGVVSYSFKFPPACCHSYLFNGGSKENAFRSVAMCAQGKNMTQLNWKGCLKRTEEFVGKKREFLIDVVTVMFILEMVCLTMGVYLPFAERRRYEDMIENEKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SLR1</accession>
    <name>A0A433SLR1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glucose-methanol-choline oxidoreductase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_022108</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001484">
        <property type="protein sequence ID" value="RUS70131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SLR1"/>
    <dbReference type="STRING" id="188477.A0A433SLR1"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="2">
        <location>
            <begin position="52"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS70131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="212" mass="23724" checksum="C510C4811CC6FB36" modified="2019-05-08" version="1">MEWPDIQLHIQNSIFKRSASRSLNMAEEMVEELGHRDAWEYGFTCMTSVPRPESRGNISLVSVDPFDPPRIYPNYLDNPYDMDILVKGLDGCRNLMTSKPMQAVGAMFLDTTPLKACGQHKFDSREYWTCAIEQRPLTIYHPVGTCKMGPRGDPTAVVDSKLRVQGLTGLRVVDASIMPWIPSANTHIPTIMVAEKAADLILGKQPPPPIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SMK7</accession>
    <name>A0A433SMK7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_021868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001425">
        <property type="protein sequence ID" value="RUS70366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SMK7"/>
    <dbReference type="OrthoDB" id="6156430at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS70366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="30885" checksum="43C3A5C8D62C628C" modified="2019-05-08" version="1">MRVHKDLFSKTAYKRVCTEFLASHPSLTINKATWPRLLKQTWDSTMREGLLKKAFEATGIYPVDRSRIPDSVFSASDAIRSMVPVVDAEEGDNPEDGAEGETTAATAEAGTGAEHHEDITQEDIAGETEDTNPVVSFDDMEQLQFLNGLMIDITDDDIEQAVDASNLVQRVDALPSPSATSTDTTPSLDAPGTSFSSAAGAWNAEIDAIFDLRPAPSKATAPKRSRAITTHRLLTSQELINEKKARLEKKEKEDAAKRERKGKALQKKLEKTQSQTTHSDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SP43</accession>
    <name>A0A433SP43_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_021214</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001284">
        <property type="protein sequence ID" value="RUS71027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SP43"/>
    <dbReference type="STRING" id="188477.A0A433SP43"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000009">
        <property type="entry name" value="Visinin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF178">
        <property type="entry name" value="NEUROCALCIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="60"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="144"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS71027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="191" mass="22016" checksum="392AB1D0CE22A777" modified="2019-05-08" version="1">MGKANSKLKPEVMEDLLEQTQFTEKELQDWYKEFLKDCPSGKLNVDEFKMIYANFFPNGDPSTFAELVFRTFDKDGNNTIEFREFICGLSVTSRAPLDRKLRWAFTVYDVDGNGFVSREEMVHIVRAIHKMVGDAVRLPNDEWTPEKRVEKILRQLDTDLDGKLSIQEFIKGAKKDPTLARLLQCDASVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SP98</accession>
    <name>A0A433SP98_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_021156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001276">
        <property type="protein sequence ID" value="RUS71078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SP98"/>
    <dbReference type="OrthoDB" id="6118055at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS71078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="309" mass="31833" checksum="375A11F52F61E3BB" modified="2019-05-08" version="1">MEACAASNVSSLSLELDRVELSNTIRYQMSSVLAMAFAYKMRISAAGGDGSRLVLQSLVPSSSVSARTSESPGLVSASSKLVGRRYSGAQNNQARGEISGEVAGMPGTHSDQLLQMFSSSLQTSPHPRLPDLPAVSATGPMSGSSADGLTNSTGGMRRQGSSPVLSSMAHQKGSLVQGYLRRRASSSALSSVSESGVDNSVVATTSSSSSSSSSSKTTPSSVVAVVRDTDADTSGELVKKSRAITPAVPTSGLQKDSSVDATDGHGSKGKGYGILNSTRRFGAWLGKVTHGEKMEVSKKDLNVFAPTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SQC6</accession>
    <name>A0A433SQC6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_020800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001211">
        <property type="protein sequence ID" value="RUS71439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SQC6"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS71439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="99" mass="11025" checksum="01BE07758919552D" modified="2019-05-08" version="1">MPIIGTTQYLSLHNYIKGEKPATATASMTMLKNKCLMCTARSTETSLVGENTNTAFLKPLHFFFLHSGPSYKQNESKNKSTLRTAVSFALPLYINPFSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SQE3</accession>
    <name>A0A433SQE3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Contactin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_020770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001206">
        <property type="protein sequence ID" value="RUS71471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SQE3"/>
    <dbReference type="STRING" id="188477.A0A433SQE3"/>
    <dbReference type="OrthoDB" id="3666223at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF6">
        <property type="entry name" value="CONTACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="C-type lectin" evidence="5">
        <location>
            <begin position="60"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="211"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="313"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="422"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="517"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="610"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS71471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="772" mass="85806" checksum="E53C223083CA48D1" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SSR6</accession>
    <name>A0A433SSR6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_019935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001084">
        <property type="protein sequence ID" value="RUS72303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SSR6"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS72303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="246" mass="26674" checksum="38CCFB8665D30139" modified="2019-05-08" version="1">MTGRFGKVGSTTLSMHRWPVCATDDDDDDDDDDDDDDDDDDDDDDDDVDDDIGDDDDDGDADFFFFFFYFFPPRPRFLVSAIRGCCDADADGGDDEYKDDGDGDADADGGDDEYKDDGDGDADADADGGDDDNYKDDVVVMIKGSARHLLVKPGSFLFDLSLINVTSDYFKHTGGFSSEVRNMSSPIACRYLKLSYWQTKVSDGLPADVTVTLLCWAIEAITGFGSANGSQRPAACGGSQVLNGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433STT7</accession>
    <name>A0A433STT7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_019555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001032">
        <property type="protein sequence ID" value="RUS72685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433STT7"/>
    <dbReference type="STRING" id="188477.A0A433STT7"/>
    <dbReference type="OrthoDB" id="409956at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22755">
        <property type="entry name" value="OTU_CeDUB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="387"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS72685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="572" mass="64021" checksum="F28494640C84F625" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433STW2</accession>
    <name>A0A433STW2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_019633</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001044">
        <property type="protein sequence ID" value="RUS72598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433STW2"/>
    <dbReference type="STRING" id="188477.A0A433STW2"/>
    <dbReference type="OrthoDB" id="6081913at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000036">
        <property type="entry name" value="CYtochrome P450 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF375">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS72598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="56981" checksum="55CBEFC7618E071D" modified="2019-05-08" version="1">MLSFLLSAVTSPWTLAAGALSLLVCYAWMKTRLKHGSSSNIPPFPAPAAPFLGHTLLLLKSDLLGSITRMRGKAGNVFSLNLLGQHLIVVSGYAPMREVLTRHADKTQDRPVDLSSQILGEEDHGLMSSRGDNWKEQRATALSILRELGLGKNVLATKTEEEVAIYIERLSSLQGKATDFRPLISAAVSNIICSIVFGHRFDYGDEYFNRIMENLNKFGAKLPHPLIFYAATYIKKLPADIFGLKEWLACIDELYTNFICLQTNKIKESYSPDTDPHNFIHAYLKLMRQKQESGTPTYLDEPNLVSNVKSIFGAGTETTGTTINWCVLYCLHHPAIQDKVFQEIDSHVGTARSPRMSDMAQLPFLTAVIRETLRIRGVLPIMAREVTRSFQLQGYLIPEGSQIIFNLKSALMDPDTWENPDEFLPERFLDSDGRLVKPSEFIPFAIGRRVCPGESMALMELHLFLASMFQRFRFEPEDSSAELPSLTGIFGVTLSPRPYKVRFVTRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SU43</accession>
    <name>A0A433SU43_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_019433</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001016">
        <property type="protein sequence ID" value="RUS72809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A433SU43"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08477">
        <property type="entry name" value="Roc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="375"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1150"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1215"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1276"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="376"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1238"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1294"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS72809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1346" mass="150592" checksum="254B34BC69E0924E" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SWX3</accession>
    <name>A0A433SWX3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_018423</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000897">
        <property type="protein sequence ID" value="RUS73806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SWX3"/>
    <dbReference type="STRING" id="188477.A0A433SWX3"/>
    <dbReference type="OrthoDB" id="5866312at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14721">
        <property type="entry name" value="bZIP_Fos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000006">
        <property type="entry name" value="fos-related antigen 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000837">
        <property type="entry name" value="AP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004826">
        <property type="entry name" value="bZIP_Maf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351:SF24">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351">
        <property type="entry name" value="FOS TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03131">
        <property type="entry name" value="bZIP_Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00042">
        <property type="entry name" value="LEUZIPPRFOS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="5">
        <location>
            <begin position="308"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="22"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="82"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="168"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="418"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="554"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="243"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="297"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="554"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS73806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="584" mass="63447" checksum="4692F7BBC1158C43" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SX84</accession>
    <name>A0A433SX84_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_018305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000884">
        <property type="protein sequence ID" value="RUS73933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SX84"/>
    <dbReference type="STRING" id="188477.A0A433SX84"/>
    <dbReference type="OrthoDB" id="5970758at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="25"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS73933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="195" mass="21520" checksum="360D4478DF0092DF" modified="2019-05-08" version="1">MDQQMSAGDLDLDGLDGRDDVTGQAEDLEGSLEMLGINGKWTRVHCSLKEPAVLTHCAECEESDDDQSTPHTTDITGYQVTELVDQIQAKRFVLRLDHQTGPPILLSLDSRDDLALWKHSITGRLDMAKHAHCDATPTTSFDQGRTGDEAPPSGEPRPLANTSSAQSIKQKLLAEMLRQRVELERMQAARAEMKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SYV9</accession>
    <name>A0A433SYV9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pseudouridine synthase RsuA/RluA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_017735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000825">
        <property type="protein sequence ID" value="RUS74504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SYV9"/>
    <dbReference type="STRING" id="188477.A0A433SYV9"/>
    <dbReference type="OrthoDB" id="9349396at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="2">
        <location>
            <begin position="573"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS74504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="647" mass="72464" checksum="DC15FF9BDEC6A077" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T0K3</accession>
    <name>A0A433T0K3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_017171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000774">
        <property type="protein sequence ID" value="RUS75065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T0K3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS75065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="109" mass="12492" checksum="17A0035D7284F485" modified="2019-05-08" version="1" fragment="single">VLFQVYSLLQTSQTCVLFQVYSLLQTSQTCVLFQVYSLLQTSQTFVLFQVYSLLQTSQTCVLFQVYSLLQTSQTCVLFQVSSLLQTSQTCVLFQVYSFLQTSQTCVLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T0Y3</accession>
    <name>A0A433T0Y3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_017041</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000763">
        <property type="protein sequence ID" value="RUS75204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T0Y3"/>
    <dbReference type="STRING" id="188477.A0A433T0Y3"/>
    <dbReference type="OrthoDB" id="10252227at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17999">
        <property type="entry name" value="DEXHc_Mot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000009">
        <property type="entry name" value="B-TFIID TATA-box-binding protein-associated factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000428">
        <property type="entry name" value="TATA-binding protein-associated factor 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044972">
        <property type="entry name" value="Mot1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044078">
        <property type="entry name" value="Mot1_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022707">
        <property type="entry name" value="Mot1_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498:SF1">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12054">
        <property type="entry name" value="DUF3535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="294"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="660"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="831"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="831"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="842"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS75204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="882" mass="97966" checksum="6A4CA3B50ED52403" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T1P6</accession>
    <name>A0A433T1P6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_016777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000741">
        <property type="protein sequence ID" value="RUS75454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T1P6"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS75454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="109" mass="12219" checksum="CCEA85B38EC8E12A" modified="2019-05-08" version="1">MHTSFYRGVITMLQSYLFHNWYGYHINALCDRHCFSTTILNIIFTLFYNIYFSGGFTYSFFLLSSPSCGLGPKPSQILHPSQTLSSVHVCHLTSSSSSSNSSSHVFACA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T265</accession>
    <name>A0A433T265_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_016620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000724">
        <property type="protein sequence ID" value="RUS75627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T265"/>
    <dbReference type="OrthoDB" id="6152726at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="8"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS75627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="242" mass="28561" checksum="832641408233EFED" modified="2019-05-08" version="1">MQLILQCIILKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKRRTRIRKQPKEVKCSVLKLGSKKSGTKYTMKEKGNGEEHEIVLEEHDVEKDLGVYVDNDLSFKEHVSRSTAKANKVVEIIRRTFDFLTEDLLVCLYKSLVRPLLEYGHSVWQPQHKTLCSDVEDVQRRATKLLASIRDKPYPERLATLKLPSLEFRRKRGDMIDLWKYIHGVYDTDRPHFDIGLGILGTPEETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T520</accession>
    <name>A0A433T520_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">EGW08_015614</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">EC2010</strain>
            <tissue evidence="19">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000648">
        <property type="protein sequence ID" value="RUS76638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A433T520"/>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:animal organ morphogenesis"/>
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        <property type="term" value="P:cell morphogenesis involved in neuron differentiation"/>
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        <property type="term" value="P:dendrite development"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="4"/>
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        <property type="match status" value="5"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="4"/>
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="Cadherin-like_dom"/>
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        <property type="entry name" value="Cadherin_CS"/>
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        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
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        <property type="entry name" value="Laminin_G"/>
    </dbReference>
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        <property type="entry name" value="FAT ATYPICAL CADHERIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026:SF126">
        <property type="entry name" value="PROTOCADHERIN FAT 4"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="3"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CADHERIN"/>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="5"/>
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    <dbReference type="SMART" id="SM00282">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 13" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1034"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="26"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="131"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="236"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="626"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="16">
        <location>
            <begin position="677"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="863"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="902"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="942"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="980"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="497"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1067"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1136"/>
            <end position="1163"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1220"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
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            <begin position="1324"/>
            <end position="1414"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="14">
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            <begin position="1547"/>
            <end position="1577"/>
        </location>
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        <location>
            <begin position="1609"/>
            <end position="1634"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="14">
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            <begin position="1227"/>
            <end position="1238"/>
        </location>
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            <end position="1402"/>
        </location>
    </feature>
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        <location>
            <begin position="1609"/>
            <end position="1621"/>
        </location>
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    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="653"/>
            <end position="662"/>
        </location>
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    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="890"/>
            <end position="899"/>
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    <feature type="disulfide bond" evidence="13">
        <location>
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        <location>
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        <location>
            <begin position="1007"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RUS76638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1634" mass="179800" checksum="AE2DEFF5678191F0" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T8E2</accession>
    <name>A0A433T8E2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">T-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_014425</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000550">
        <property type="protein sequence ID" value="RUS77808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="188477.A0A433T8E2"/>
    <dbReference type="OrthoDB" id="7442607at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.820:FF:000023">
        <property type="entry name" value="CSON002431 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.820">
        <property type="entry name" value="Transcription factor, T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046360">
        <property type="entry name" value="T-box_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036960">
        <property type="entry name" value="T-box_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001699">
        <property type="entry name" value="TF_T-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018186">
        <property type="entry name" value="TF_T-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267">
        <property type="entry name" value="T-BOX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267:SF190">
        <property type="entry name" value="T-BOX TRANSCRIPTION FACTOR TBX20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00907">
        <property type="entry name" value="T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00937">
        <property type="entry name" value="TBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00425">
        <property type="entry name" value="TBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01264">
        <property type="entry name" value="TBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50252">
        <property type="entry name" value="TBOX_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="T-box" evidence="7">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS77808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="281" mass="31461" checksum="EE0A5A818A0D6A4E" modified="2019-05-08" version="1" fragment="single">RSSWLVAGKADPPLPARLHLHPDSPFSGEHLMKQTVSFEKVKLTNNMLDKNGHIILNSMHKYQPRVHLVRKTESTKLPITSLEGLDVTTYVFPETVFIAVTAYQNQLITKLKIDSNPFAKGFRDSSRLTEFDRETMESLLHNHSYARSPLRAFSEAEFEEAIKNRDSKDHAAALSLLYTWRMQSASLLPGQPPATTSMLGPSPYAAMYGSFLSHAYRGALEAAPSPADMRSGNAAMMNEAILRSSLYKQSMTSTLAAAAYQRGLYRYHPYLPPDRVRSPDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TDR7</accession>
    <name>A0A433TDR7_ELYCH</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_012550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000434">
        <property type="protein sequence ID" value="RUS79696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TDR7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS79696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="99" mass="11619" checksum="557EC2DAF715DFCC" modified="2019-05-08" version="1">MMICMFFYLPPFSPIHPPLPSWSNILNLFSLNVCFAYDSMILMRPEKDELSIVYILLIIEIICSTKRPNFIPQRNNTDVADECILVDNLLARLKEMLFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TI94</accession>
    <name>A0A433TI94_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_010936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000345">
        <property type="protein sequence ID" value="RUS81294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A433TI94"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF46">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="12"/>
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            <end position="94"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS81294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="2473" mass="273663" checksum="BBD6288D9FB920EA" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TKG6</accession>
    <name>A0A433TKG6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_010204</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Toll-like receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000307">
        <property type="protein sequence ID" value="RUS82048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TKG6"/>
    <dbReference type="STRING" id="188477.A0A433TKG6"/>
    <dbReference type="OrthoDB" id="6107924at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365:SF541">
        <property type="entry name" value="PROTEIN TOLL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365">
        <property type="entry name" value="TOLL-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01582">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01537">
        <property type="entry name" value="INTRLKN1R1F"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="TIR" evidence="12">
        <location>
            <begin position="757"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="898"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS82048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="939" mass="106880" checksum="056A579413A2C60F" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TKI1</accession>
    <name>A0A433TKI1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_010166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000305">
        <property type="protein sequence ID" value="RUS82058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TKI1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS82058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="162" mass="18082" checksum="36C7ADAB8332287C" modified="2019-05-08" version="1">MQTHVIQAKINLFRAEKLFNSPSAFVCLHSGSLRLISSYFVSCQLTSARFNELRIISARFGSLRLTLCHANSLRLVSMNFGSFRLISSHFSLLCVILAHFGLLRIISAHFDSLRLILAQFGSFQPTSAHFAAIRLILAHFGSIRLVSHHPGLHLLTSTQFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TLY2</accession>
    <name>A0A433TLY2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glyoxalase domain-containing protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_009667</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glyoxalase I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000280">
        <property type="protein sequence ID" value="RUS82593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TLY2"/>
    <dbReference type="STRING" id="188477.A0A433TLY2"/>
    <dbReference type="OrthoDB" id="5371818at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07253">
        <property type="entry name" value="GLOD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050383">
        <property type="entry name" value="GlyoxalaseI/FosfomycinResist"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21366:SF14">
        <property type="entry name" value="GLYOXALASE DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21366">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="3">
        <location>
            <begin position="49"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS82593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="176" mass="19432" checksum="61473011BC41501C" modified="2019-05-08" version="1">MIRRFSTSIIRHLWLANQCQAPVAAGSSSTFHSNLQSCGFATRPFQIAGLDHLVLTVQDLDKTVEFYTKVLGMEATTFRGGRKALNFGEQKINLHEKGNEFNPKAEVPTPGSADLCFITPTGLDDVQEHLHKCNVPVIEGPVERTGAVGGIRSVYIRDPDGNLIEISNYIKRVIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TM07</accession>
    <name>A0A433TM07_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_009642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000280">
        <property type="protein sequence ID" value="RUS82568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TM07"/>
    <dbReference type="OrthoDB" id="6159458at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS82568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="669" mass="73534" checksum="6A422F279492A7D0" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TM85</accession>
    <name>A0A433TM85_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Twinfilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_009577</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with G-actin; ADP-actin form.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000276">
        <property type="protein sequence ID" value="RUS82674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TM85"/>
    <dbReference type="STRING" id="188477.A0A433TM85"/>
    <dbReference type="OrthoDB" id="10006997at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030016">
        <property type="term" value="C:myofibril"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010976">
        <property type="term" value="P:positive regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010591">
        <property type="term" value="P:regulation of lamellipodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11284">
        <property type="entry name" value="ADF_Twf-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11285">
        <property type="entry name" value="ADF_Twf-N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000042">
        <property type="entry name" value="Actin depolymerizing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000007">
        <property type="entry name" value="Twinfilin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028458">
        <property type="entry name" value="Twinfilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759:SF1">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ADF-H" evidence="12">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="ADF-H" evidence="12">
        <location>
            <begin position="128"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS82674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="292" mass="32948" checksum="9400ADB8D726F514" modified="2019-05-08" version="1">MPHYDAMVLPLLEEKMPCYIMYRLDSQNDMGYEWLFITWSPDFAMVRHKMLYAATRATVKMQFGGGQIKDELFGTVQQDVSLSGFRRHEQAAKAPAPLTMAEEELQLIKQTEVNAHINVDSKSQTMQGVSFPLTDEASDAVASFLQGSINYVQLELDLTKEIVNVSATDTFKVKNLVSHVPTDSARYHLYNFSHTHEGDATDSVVFIYSLPGFKCSIKERMLYSSGKSPLVEQLEAMGVVIEKKIEVDDPNELTEEFIYDEVHPKKNVARQAFAKPKGPAGRGPKRMTRPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TN40</accession>
    <name>A0A433TN40_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_009240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000262">
        <property type="protein sequence ID" value="RUS83003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TN40"/>
    <dbReference type="OrthoDB" id="6156820at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="494"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="575"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="600"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS83003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="799" mass="85256" checksum="88D774DA25BB1B48" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TNG2</accession>
    <name>A0A433TNG2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Acyl carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EGW08_009108</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">EC2010</strain>
            <tissue evidence="16">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000257">
        <property type="protein sequence ID" value="RUS83119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TNG2"/>
    <dbReference type="STRING" id="188477.A0A433TNG2"/>
    <dbReference type="OrthoDB" id="448946at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000035">
        <property type="term" value="F:acyl binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000008">
        <property type="entry name" value="Acyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002148">
        <property type="entry name" value="PRK00982.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="ACYL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863:SF28">
        <property type="entry name" value="ACYL CARRIER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 14" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Carrier" evidence="15">
        <location>
            <begin position="9"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RUS83119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="92" mass="10740" checksum="41EBB969BF1E5264" modified="2019-05-08" version="1" fragment="single">QRWYAGKAPLTLETVQKRVELVLKLYDKINPEKLSLDSHFINDLGLDSLDQVEIIMAIEDEFGFEIPDADSERLMRPRDIVQYIADKEDVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TNJ8</accession>
    <name>A0A433TNJ8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_009102</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the VTI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000256">
        <property type="protein sequence ID" value="RUS83155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TNJ8"/>
    <dbReference type="STRING" id="188477.A0A433TNJ8"/>
    <dbReference type="OrthoDB" id="430637at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903076">
        <property type="term" value="P:regulation of protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15890">
        <property type="entry name" value="SNARE_Vti1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000002">
        <property type="entry name" value="Vesicle transport through interaction with t-SNAREsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.400">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027027">
        <property type="entry name" value="GOSR2/Membrin/Bos1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038407">
        <property type="entry name" value="v-SNARE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007705">
        <property type="entry name" value="Vesicle_trsprt_v-SNARE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF89">
        <property type="entry name" value="VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05008">
        <property type="entry name" value="V-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028865">
        <property type="entry name" value="Membrin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="123"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS83155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="217" mass="24749" checksum="7EEAC4BFB4EA50DF" modified="2019-05-08" version="1">MSSEKFESLESDLNDIIETLHEGEKRLNAYNGEERKIAYRKAERKLEEANILVQDMEGEAKLAPVNYRTQMLGRIRHYRNDIDQLARNLKRGSGGGSRGADNFGFDRNERLETSNRAKLFQGHQSLQRASESIARSHQIAAETDQIGVEIIDELGTQRETIERARDRLEETDVNLGRSRGILKSMARRVTTDKLILALIIVVELAILGGITYWKFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TNW3</accession>
    <name>A0A433TNW3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">COMM domain-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_008959</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the COMM domain-containing protein 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000250">
        <property type="protein sequence ID" value="RUS83279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TNW3"/>
    <dbReference type="STRING" id="188477.A0A433TNW3"/>
    <dbReference type="OrthoDB" id="1917519at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04751">
        <property type="entry name" value="Commd3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017920">
        <property type="entry name" value="COMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037355">
        <property type="entry name" value="COMMD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31159">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31159:SF1">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07258">
        <property type="entry name" value="COMM_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21672">
        <property type="entry name" value="COMM_HN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51269">
        <property type="entry name" value="COMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COMM" evidence="3">
        <location>
            <begin position="124"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00093469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS83279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="195" mass="21860" checksum="8FD16E8BDA2E1B70" modified="2019-05-08" version="1">MELGASVLENISLAGDVAHIPDKLFGKFVMSACQGVLFEKHRDAVSDNPAFKDVDKATMKAAYSGLVNLLLEAAKHDTTEQNLSTLLEECKYTTERIKEFNKIFLAQKSHIQLLLGKVGSSFPHIVDIDWRLDYYMKNNHMEKVNAAVYLISLKTEVPGEAELRDIQFSCSLEQLQDLVGKLRDATKCLEKIAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TVD9</accession>
    <name>A0A433TVD9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_006693</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(His) + L-histidine + ATP = L-histidyl-tRNA(His) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="2"/>
    <dbReference type="EMBL" id="RQTK01000166">
        <property type="protein sequence ID" value="RUS85550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TVD9"/>
    <dbReference type="STRING" id="188477.A0A433TVD9"/>
    <dbReference type="OrthoDB" id="1906957at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000008">
        <property type="entry name" value="histidine--tRNA ligase, cytoplasmic isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000021">
        <property type="entry name" value="Probable histidine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476:SF7">
        <property type="entry name" value="HISTIDINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476">
        <property type="entry name" value="HISTIDYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="11">
        <location>
            <begin position="95"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="56"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="164"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="365"/>
            <end position="366"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001549-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS85550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="526" mass="58237" checksum="0FF1D0B793BBEEAC" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TVW3</accession>
    <name>A0A433TVW3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SEFIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_006548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000162">
        <property type="protein sequence ID" value="RUS85672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TVW3"/>
    <dbReference type="OrthoDB" id="6158429at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS85672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="863" mass="95861" checksum="6C9382684461865D" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TWE2</accession>
    <name>A0A433TWE2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_006409</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="RQTK01000158">
        <property type="protein sequence ID" value="RUS85857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TWE2"/>
    <dbReference type="STRING" id="188477.A0A433TWE2"/>
    <dbReference type="OrthoDB" id="6152825at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="28"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="4">
        <location>
            <begin position="301"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="384"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS85857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="412" mass="45794" checksum="D13613AD7F844A9D" modified="2019-05-08" version="1">MYIKVQIKQIFRFRKEVGSMKFPIFSMQEGCGKTFFIEIILASQRAKGSIAIATASTGLAATLLPGGRTVHSTFKVPLNIINAETPSCSIKKGTALSRVLQDASVLIVDEATLLHRKVIEAIDTTLKDIRSSSEVMGGLLTLLCGDFRQILPVIRQGTRANIVDACLKSSSLWRLVQQYRLTTNMRVALQADERAEMFANKLLRLGNGETDTVQSPDYVSLLNFGTPADNIDIILDRIYPQIHSNYENHTWLMQRAILAPHNDSVSQINKLLAEKLPTQTHTYTAINSVVDEEQAVQFPVEFLNSIEVSELPPHVLDLKCGMPVMLLRSIKPPELINGTRCIIHNCDRHFVEVEIAAGIYSGQNDKSQTHSSVRSTVRVVCCPSKDKTPSKRESRTPTQKPCLAHSRSPKMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TXD0</accession>
    <name>A0A433TXD0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_005982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000145">
        <property type="protein sequence ID" value="RUS86240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TXD0"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS86240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="226" mass="23783" checksum="595F290608EB16FE" modified="2019-05-08" version="1">MGSFKVVVVEEEDVLVVVVVVDVGGGGGAGGGVVVVVKYIQRRGFFTWILVFLIPFKSLNTAALERLAQVVSIRDLLKPSAIVLFTLSPNPPGPELEVTDDAVIRPGRVLVFLPAAAGHDSVAVAAVHPAAALLALARVVTRPLCGQGGGVEGELKERIRTNSLDSSWLERLWIVVHLVGDTLVSSSRTSSRSITQTSLGLQQPASLVHSSFVAEHFKGGEGVGHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TZM0</accession>
    <name>A0A433TZM0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Fanconi-associated nuclease</fullName>
            <ecNumber evidence="17">3.1.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">EGW08_005182</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">EC2010</strain>
            <tissue evidence="19">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.</text>
            <dbReference type="EC" id="3.1.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="17">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the FAN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.1" evidence="17"/>
    <dbReference type="EMBL" id="RQTK01000121">
        <property type="protein sequence ID" value="RUS87029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TZM0"/>
    <dbReference type="STRING" id="188477.A0A433TZM0"/>
    <dbReference type="OrthoDB" id="76364at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070336">
        <property type="term" value="F:flap-structured DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004528">
        <property type="term" value="F:phosphodiesterase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22326">
        <property type="entry name" value="FAN1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.10:FF:000004">
        <property type="entry name" value="Fanconi-associated nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033315">
        <property type="entry name" value="Fan1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049132">
        <property type="entry name" value="FAN1-like_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049126">
        <property type="entry name" value="FAN1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014883">
        <property type="entry name" value="VRR_NUC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749:SF4">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21170">
        <property type="entry name" value="FAN1_TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08774">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00990">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 17" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14 17" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 17" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 17" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VRR-NUC" evidence="18">
        <location>
            <begin position="527"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU365033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RUS87029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="644" mass="73171" checksum="D73F6247C9C8DC67" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U137</accession>
    <name>A0A433U137_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_004727</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000108">
        <property type="protein sequence ID" value="RUS87551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U137"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS87551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="227" mass="25482" checksum="1AFE3AAD752082E3" modified="2019-05-08" version="1">MCLFLCLYCQPHHLKVLKNKGEAKALGLIKEDGFLVNQEILMQGRLLMRGLSPGSGLCLSLDRALDDRKYTRSLVVFFSDLTQWETGVLRNTREAKALGLMGEDGYLANPDVLRNKREAKALGLTDMDGFLVNLAILLQGHLLMRDLCGGRSLLVDRTRIDFLTKCSWMCFHRPPADAGLVLRNTREAKALGLMGEDGYLANPEVLHQDLRHSRLGRRRSQATFIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U363</accession>
    <name>A0A433U363_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_003966</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000088">
        <property type="protein sequence ID" value="RUS88264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U363"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS88264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="229" mass="23524" checksum="F85C47C473CF192C" modified="2019-05-08" version="1" fragment="single">MADLVQVGQVCGPREPGHGRLVQASLQHDALADVAQRAGDLPGWNLALEHVAHVQARAPVARHVRKLCIDLWCTHISPASHGVDGVVPAQLVRPIHVQNLVPVPPSSSTMKYEPCTHISPASHGVDGVVPAQAEVHDAPVDGLAAALGGEVLLGHLHPAQGAHGVADSLLAAGGPATLAAGVGPGSEGQEERVVVVVGVTFELRQVALCARPGSGAARSRRDGTHGAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U8C7</accession>
    <name>A0A433U8C7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_002188</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000041">
        <property type="protein sequence ID" value="RUS90075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U8C7"/>
    <dbReference type="OrthoDB" id="422206at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF27">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 49 MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS90075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="48460" checksum="CB2021502BAC3FBB" modified="2019-05-08" version="1" fragment="single">QVYKRRWYILILFSLVCFTQGLMWNTFGPISTSSERVFGWGDPTIAWLSALGGLSFLITSFPVYWLMQVKGERGVTELKGALGRIMDLYWEEIAMGVKWRIVNTCFLINLGQFIAGFATPVSMGACPTLSATWFPQDERVTATAISASIGVFGVASAFVLGKVKPCYIRVIYMYFNPPYVSCIIRLMFSLYPLTLECGWAGLLFLAIVCYFPNTPPCPPSISAFSERHTFWAGLRSLFRNRDFVIISLTYGFTAGVFGAWQSVLTVNLKPAGISQDEAGWLGFYSVVSGCLASVLVGRFADRFLRHMKLFILVMYTLATACFIVFSLELFGPMLPHSEGLLYASVICGGTLLLGATPLMFELGCEIGYPASESAANGMFALFNNLTGVTFMIPFAIPHIGTMWMNWVFVGFCLASLPLVAVVRSSFNRLNLDEEVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UB59</accession>
    <name>A0A433UB59_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_001182</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000019">
        <property type="protein sequence ID" value="RUS91054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UB59"/>
    <dbReference type="OrthoDB" id="9989228at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS91054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="107" mass="12026" checksum="EA454426039BE901" modified="2019-05-08" version="1" fragment="single">YGTFGYSLLIINTHLRAGVGHAVAKYLADAFSDSFVRKVFVLSALRLDHLERKSHQELFENTWNGMCPGTEYPELPKGMKIFDPLLCDMIQMFLIEGISFSVISIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UDG6</accession>
    <name>A0A433UDG6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Essential protein Yae1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_000436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000005">
        <property type="protein sequence ID" value="RUS91865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UDG6"/>
    <dbReference type="STRING" id="188477.A0A433UDG6"/>
    <dbReference type="OrthoDB" id="6150444at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038881">
        <property type="entry name" value="Yae1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18829">
        <property type="entry name" value="PROTEIN YAE1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18829:SF0">
        <property type="entry name" value="PROTEIN YAE1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS91865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="23855" checksum="12EA13B47CB4887C" modified="2019-05-08" version="1">MAAVHTMSEPPTKINEPFALSSDDEDFSLMHKEWSKIDEGLKNAGIRDALESSQDHVLQEGFNAAFRKTLQMAMSAGKLQGSISAMLSYQALAVDSEDGKHSESVLSESTQTQLQELLAENTRLLSSIPQIVENADHKAGGYGRSEITQTGHKNSGASDTDSVSPCLEVYNGPRDGAGQGNQTGASSQGCEQVCSNRSHFWSQLESFKVQARPLGIFTDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UDN3</accession>
    <name>A0A433UDN3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Complex III subunit 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_000291</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UQCR10/QCR9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000004">
        <property type="protein sequence ID" value="RUS91889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UDN3"/>
    <dbReference type="STRING" id="188477.A0A433UDN3"/>
    <dbReference type="OrthoDB" id="6133085at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.260:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.260">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008027">
        <property type="entry name" value="QCR9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036656">
        <property type="entry name" value="QCR9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12980:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12980">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX, SUBUNIT X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05365">
        <property type="entry name" value="UCR_UQCRX_QCR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81514">
        <property type="entry name" value="Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS91889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="67" mass="7793" checksum="87531687C9672DE6" modified="2019-05-08" version="1" fragment="single">SSLANLSKNVYHAVFRRTSTFVIAVVVMAYPFERAFNVGTERYFRFINKGKFYDDIKSQFGQDGEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-05-03" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z6S1</accession>
    <name>A0A3S0Z6S1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_020332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001142">
        <property type="protein sequence ID" value="RUS71903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z6S1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS71903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="213" mass="23633" checksum="F990274E6AB73554" modified="2019-04-10" version="1">MAAAGAAAAAKYFGVNCHGPKTPQPRQTANDCIQSVQTFTPNHPARHGTGCRLRFAVERAIARPRASQTQPLLWRGFHYPQRGRHPTPHPPVGPSRPRYAHSQPVGYRITRTSSLTGRQHKFWGAGTTGDRGASGQQMEPAMGTDEYDSTPYGVFEFLDIVYDFGSSKSNTRKFATPKRGQRVSAREDSRFARHQSRVECLPNTVKAMFKYGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z6Y5</accession>
    <name>A0A3S0Z6Y5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_023829</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01003609">
        <property type="protein sequence ID" value="RUS68409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z6Y5"/>
    <dbReference type="OrthoDB" id="10692523at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS68409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="247" mass="28261" checksum="21D4D7B17B4BD365" modified="2019-04-10" version="1">MVTTWLCWISHLNVFNCVSHLNVFGWMVTTWLCWISHLNVFNCVSHLNVFGWMVTTWLCWISHLNVFNCVSHLNVFGWMVTSVWLDGDYLVVLGFSPEGVWLDGDYLVVLGFSPDGFSPERVWLDGDYLVVLDFSPERVWLSGVYLCSVLGFSPERVWLDGDYLVMLDFSPERVWLDGDHLVVLDFSPEGFSPEGVWLDGDYMVVLGFSPEGVWLDGDYLAVLDFSPERVWLDGDHLVVLDFSPEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZAV8</accession>
    <name>A0A3S0ZAV8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_017511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000804">
        <property type="protein sequence ID" value="RUS74737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZAV8"/>
    <dbReference type="STRING" id="188477.A0A3S0ZAV8"/>
    <dbReference type="OrthoDB" id="6063402at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050784">
        <property type="entry name" value="IAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044:SF139">
        <property type="entry name" value="DEATH-ASSOCIATED INHIBITOR OF APOPTOSIS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044">
        <property type="entry name" value="INHIBITOR OF APOPTOSIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS74737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="122" mass="14581" checksum="78EECBE146181AC5" modified="2019-04-10" version="1" fragment="single">EEDNKKNDARQQSKKNFIPLPRTDPEKKPNIWASDEMRTSVYPEMVNVNDRLKSFNHYLQKHHHHHRVLADLGFFYSGGDCIRCFHCGLELRNWLPDDDVAKEHYQYSPSCDYPLRSKGWEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZCJ0</accession>
    <name>A0A3S0ZCJ0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_017684</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000820">
        <property type="protein sequence ID" value="RUS74559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZCJ0"/>
    <dbReference type="STRING" id="188477.A0A3S0ZCJ0"/>
    <dbReference type="OrthoDB" id="6143803at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="7">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="7">
        <location>
            <begin position="85"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS74559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="120" mass="13612" checksum="C585494A1A22577F" modified="2019-04-10" version="1">MSNDARVTRVAGKSVEYKSWLNTVNRKYKHIGQVFMKMYRTEGLRSIYRGFTPTMLGAIPYSGCSFFTYETLKKLHAELHQGRDPNPLERMVCGAVAGMVGQSASYPLDIVRRRMQTAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZHE7</accession>
    <name>A0A3S0ZHE7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">EGW08_014530</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">EC2010</strain>
            <tissue evidence="20">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000559">
        <property type="protein sequence ID" value="RUS77694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZHE7"/>
    <dbReference type="STRING" id="188477.A0A3S0ZHE7"/>
    <dbReference type="OrthoDB" id="5980076at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752:SF10">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 16" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14 16" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 16 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="19">
        <location>
            <begin position="64"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="397"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="397"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="429"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RUS77694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="444" mass="48336" checksum="A7BEAFBC18373191" modified="2019-04-10" version="1" fragment="single">SAVVHSSSTGHDTGRDGVSLPTSDPGSVSNSSSREPSASGVTMSSQTIVLGLILVLVLVASLVANAFVLIVFCKRKSLSLSNRFVANLTICNCLNAFFVMPFALASLLSQRWLFGDAWCICTGFLMSVLVSASILTLAVMSIDRYFAVVTPLHYSMRLTSRRCSLLILSIWAGAILISAPPIFGWNSIGFQVDKMVCTVRWSSRRSLDAYYTFFLVSCSFLVPLVAMLWTYARIFRAARGNSVRARRNSVIRGIGSLSQHSATPLNGRRRSSTVPIIRRLSHSSSRSSSLLWRMEEWKTAVTSFLVLSSFAVCWAPYFVVMSVEAAIGVSDWPLISSVSIVLAMASCAVNPLVYVFRNKVFRKDLRLIVQRRRFWFLGGGGSAGAAKDAICVPQEISGTGSSTGGQAPSSRRTSVVRNESGRSLKSMAELEEREEGGAEEMEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZKI0</accession>
    <name>A0A3S0ZKI0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_012380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000424">
        <property type="protein sequence ID" value="RUS79854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZKI0"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS79854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="227" mass="24316" checksum="83E93D73F999DA53" modified="2019-04-10" version="1">MKVNCGRGATVPFGEGGGDNCVGLAEWTVVDIGALLENAQQWRQPLSARIVPTEKDGCVRFPSPPHPFPCSMTTCINQFQSRDQPAISCLEAARSTLGPSPPALPNCPIMFLVDPDQHSASNAIYPRIPDNQFEMSSPLPQVGLPGERGSQSAGLRVNISPPGQPLLSLARLSSSPLTDFRNSVKHLKWLVLQADIIDLGIQDKDKIKVVDSKPESENVPICGALSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZLP9</accession>
    <name>A0A3S0ZLP9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_011581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000379">
        <property type="protein sequence ID" value="RUS80677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZLP9"/>
    <dbReference type="STRING" id="188477.A0A3S0ZLP9"/>
    <dbReference type="OrthoDB" id="2187496at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS80677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="480" mass="50884" checksum="77BFD64DB4355891" modified="2019-04-10" version="1">MNKVPQKPFIPDKPAPSPLGPASCYTFCLLYIFVCMQLFSTAADKSPATQPPSAIPRLTSQPLPGPAPFPVAPPPVIEKERESPAPKSPISPVAAPVSPVSGTAPTASFASPTPPKVGAPRPATTFMSPRPYAAPALPPKPAPSLLLSKKDTPPPPSATFIPKPVQFVPPKKPDGVSSSPSPSKPTPPTKPTGSSLPTRPVTFTPSPRQSSALSPKPAPFSPPSGEASATGPRPAPFVPPSRPISGGGPKPAPFYPPTSLPRPVTFAPRPPLGPKPGTGPGDEVTSPVSPTSPTNILDVRKSARMPSGIPKKAATNADIEKMSFREKQKYFEKEIQDSSAPKAPGEEGDVTADHDLDQVLSNYTHPAQQLEGAGSNPTPWWPGAESVSLRAREAEQRASWRRARFNPTYSYHNHYYLNYVRMKSLEVDAVQAQAVIAKAQELSREPANGAQLNHPNHNGDSRVELTGNQILNKGLSESRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZN79</accession>
    <name>A0A3S0ZN79_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_020892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001229">
        <property type="protein sequence ID" value="RUS71349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZN79"/>
    <dbReference type="STRING" id="188477.A0A3S0ZN79"/>
    <dbReference type="OrthoDB" id="6122938at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS71349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="23497" checksum="68E74F33313712EE" modified="2019-04-10" version="1">MLHQTKEHSDDEIEKFYEELDNVKNNLKTQDVKIVMGDFNAKVGNKRIEDTICPHGIEDFCITCECIGIQTYSNCSNSKYFHDKIKDVAGRKPSPKSSCIKSQSGQFLVDIDDILKKWSQYAEELFDDPRPPIRNNKGPPIMEEEVRNAIRKMKHNKATGPDEIPVELFDALNETCLIHFTKLLNLIYDTGQWPSDWKKNQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZQP2</accession>
    <name>A0A3S0ZQP2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Spermatogenesis-associated protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_019168</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May play a role in apoptosis regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000980">
        <property type="protein sequence ID" value="RUS73071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZQP2"/>
    <dbReference type="STRING" id="188477.A0A3S0ZQP2"/>
    <dbReference type="OrthoDB" id="62528at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051493">
        <property type="term" value="P:regulation of cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000061">
        <property type="entry name" value="Spermatogenesis associated 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010441">
        <property type="entry name" value="CH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052111">
        <property type="entry name" value="Spermatogenesis_Ciliary_MAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12509">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12509:SF8">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06294">
        <property type="entry name" value="CH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CH-like" evidence="6">
        <location>
            <begin position="8"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="211"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00058372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00071322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS73071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="273" mass="32006" checksum="0DC8CEA402B91A38" modified="2019-04-10" version="1">MSGVSREVLKWLQSLDLTWQIKNPKWDLSNGYLIAEIFSWYFPQDIQLHSFYNRQSLELKKRNWYILKNFILRNDIDLKMEDVDGTIHCREGAAAQLIESLYEILTNRRVKKIPPEIEVDYTDHAYQLQLPMHARSTASKAVKNNLRLTEVIADQNIITCAQKPGWFSDRSVFKSQRIINEHIEHRREERLQDPQRFGIKATLGDRCVRRPEPPQQIQSEPSHISNTTDIPAELAGDCNSERPLTREPSVHFKEVEVKQMDKSAFYQLPIQSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZS53</accession>
    <name>A0A3S0ZS53_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_007703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000202">
        <property type="protein sequence ID" value="RUS84534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZS53"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS84534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="343" mass="36172" checksum="6D23BC46F44017FA" modified="2019-04-10" version="1" fragment="single">MATTELKEPPFYLSSHNSARLPKLPSAVGSSAVSPPTSPPAGSEQQFSNNYHHHHPHHPHQVSSDIQVHSRAKHLNHRDQNHLNHHNVTGLSADHRDHVTAESSSGTTSRTFPSPVLGPLIPHSGKAPTLILSPEEAAAAAGREVNGNYYAHSANSGIALHHGSDPRSSKDCLSGPNDSSSGFNSSSELVLKMPGHAFRCDGEDSINGNPIGNNADDCEVPTTNGEVQCNCECDSPNAKTGRHLENRQRERDLEAVGQKCGLPYVVTDGALRSLSSSSSSGSSSLSCQKCHGSRPEPSGQPGSHVTFQIGENGGLHEEQENNALSNNHLASSSLSSLSSSAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZSX3</accession>
    <name>A0A3S0ZSX3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_010291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000313">
        <property type="protein sequence ID" value="RUS81946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZSX3"/>
    <dbReference type="STRING" id="188477.A0A3S0ZSX3"/>
    <dbReference type="OrthoDB" id="9996127at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032006">
        <property type="term" value="P:regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031793">
        <property type="entry name" value="KICSTOR_ITFG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16317">
        <property type="entry name" value="INTEGRIN ALPHA REPEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16317:SF1">
        <property type="entry name" value="KICSTOR COMPLEX PROTEIN ITFG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15907">
        <property type="entry name" value="Itfg2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS81946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="624" mass="68694" checksum="A7216555170B3F73" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZTX8</accession>
    <name>A0A3S0ZTX8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_009538</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000275">
        <property type="protein sequence ID" value="RUS82701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZTX8"/>
    <dbReference type="STRING" id="188477.A0A3S0ZTX8"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000017">
        <property type="entry name" value="dnaJ homolog subfamily C member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051434">
        <property type="entry name" value="DnaJ_C_subfamily_member5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44027">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44027:SF7">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0564">Palmitate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="17"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="149"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS82701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="226" mass="24551" checksum="E0F27FA811A242F4" modified="2019-04-10" version="1">MSQIPQRTRTYSRSGTSLYELLGLKKGATNEEVKKAYRRLALKYHPDKNRDDPDAADKFKEINRANTILSDSTRRGIYDRYGSLGIYAAEQFGEENVNTYLVLTSGWCKAFAIFCGIITGCYCCCCCCMCCNFCCGKCRPGPPSDEGDYANLHDEAGTTPEDEEPVTSQPISLGPPAGVEKKKEDEEEVEGEAVPDERTNLHTGLNQPSYGADVSAGAGGDGGGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZV04</accession>
    <name>A0A3S0ZV04_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_005745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000137">
        <property type="protein sequence ID" value="RUS86495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZV04"/>
    <dbReference type="STRING" id="188477.A0A3S0ZV04"/>
    <dbReference type="OrthoDB" id="1702031at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS86495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="130" mass="15397" checksum="10ED1192C0753C1C" modified="2019-04-10" version="1" fragment="single">RIQLKSSRVQFKSSRIQLKSSRIQLKSSRIQLKSSRIQLKSSRIQFKSSRIQLKSSRIQFNEFGAMEFKSSRIQLKSSRIQFKSSRIQLKSSRVQFKSSCIQLKSSRVQFKSSRIQFKSSRIQFRNVKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZZF0</accession>
    <name>A0A3S0ZZF0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_013283</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000480">
        <property type="protein sequence ID" value="RUS78942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZZF0"/>
    <dbReference type="STRING" id="188477.A0A3S0ZZF0"/>
    <dbReference type="OrthoDB" id="10063208at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039958">
        <property type="entry name" value="RYBP/YAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033774">
        <property type="entry name" value="YAF2_RYBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12920:SF4">
        <property type="entry name" value="GEO03726P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12920">
        <property type="entry name" value="RYBP AND YAF2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17219">
        <property type="entry name" value="YAF2_RYBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="10">
        <location>
            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="61"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS78942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="161" mass="17744" checksum="62DF45D365731258" modified="2019-04-10" version="1">MDEKRSSGRSKRQAKVLDEGFWDCSVCTFKNSPEAYKCEMCDVRKGTSTRKPRINPQLVALQKAQQFQPPPKKEKSHSSKRDKNGEGGSDSNSFPRLKNVDRKNPSHLSVTVGNVTVVMTDFQPKPDSRLSDSHLSSDASDSNSVTAPDLTDDSSRDAAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZZR8</accession>
    <name>A0A3S0ZZR8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_001406</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000024">
        <property type="protein sequence ID" value="RUS90787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZZR8"/>
    <dbReference type="STRING" id="188477.A0A3S0ZZR8"/>
    <dbReference type="OrthoDB" id="10062389at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053110">
        <property type="entry name" value="Ribosomal_L1-TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48162:SF1">
        <property type="entry name" value="RIBOSOMAL L1 DOMAIN-CONTAINING PROTEIN CG13096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48162">
        <property type="entry name" value="YALI0A06930P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="263"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS90787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="361" mass="40461" checksum="DE0384F378049C7D" modified="2019-04-10" version="1">MKGIRNRKQHGNGYLKKEVAIFPEKCYINFDYYYYYDDDGDDDDGDDDDGDDDDGDDDDGDDDDGDDDDDDDDDDDDDDDDDDDDDDDDDDIVFIHSPSISCATVASRAAPRRHHCPLLQKLGVSCFGQCCRFIHLGFTACPKIVRQRPLPQKLRVFLCDRQRGFPHLEGRAPIGGLYRNSVTFQPHGPSLHATRAIRSCQQVAAWLLQVSPPLLALYGILINFQNIGFTGNPPLFVQNVIANRQSQVKVGSSLSDSFEQGALRGSVLSPILFGIQINSIAEILKNNVNFSLYVDDFAVCYKASSIPTMQRQLQLHLNVHQKWSGTNGFKVSPQKTILFNFAMKEISQGFVSLHRARPKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A0R7</accession>
    <name>A0A3S1A0R7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_012434</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000427">
        <property type="protein sequence ID" value="RUS79787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A0R7"/>
    <dbReference type="STRING" id="188477.A0A3S1A0R7"/>
    <dbReference type="OrthoDB" id="10046198at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000037">
        <property type="entry name" value="B-cell lymphoma/leukemia 11A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001175">
        <property type="entry name" value="Zinc finger, C2H2 type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051497">
        <property type="entry name" value="Dev/Hematopoietic_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056438">
        <property type="entry name" value="Znf-C2H2_CTCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45993">
        <property type="entry name" value="B-CELL LYMPHOMA/LEUKEMIA 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45993:SF6">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23611">
        <property type="entry name" value="zf-C2H2_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="85"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="118"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS79787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="147" mass="16167" checksum="77040E9DE2A1A9DE" modified="2019-04-10" version="1" fragment="single">SSPTRLLLPSNGSGLTPRKPEASKRNDTCEYCGKVFKNCSNLTVHRRSHTGEKPYKCSLCSYACAQSSKLTRHMKTHGRLGKDVYTCKFCNMPFSVPSTLEKHMRKCVENRNAHLMGQDAGDLSSESTGDLSLHSEPADLSSGGQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A1N2</accession>
    <name>A0A3S1A1N2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibrinogen C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_000573</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000008">
        <property type="protein sequence ID" value="RUS91600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A1N2"/>
    <dbReference type="STRING" id="188477.A0A3S1A1N2"/>
    <dbReference type="OrthoDB" id="6146709at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF327">
        <property type="entry name" value="FI21813P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018536701" description="Fibrinogen C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="2">
        <location>
            <begin position="17"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS91600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="223" mass="25859" checksum="562B8CC1EB3E9796" modified="2019-04-10" version="1">MDKVLIFLVLVVLTYVTATWAMIPRCHEGMGLHIPVVYRIRERINRQSHTILCDTATDGGGWIILQRRYRFTVSFERNWEEYKYGFGSLDDDYWLGLEYVSSLTAHGTWELRVDLSDNGPRSYVIWSNFRIGNESDGYRLYLWGEKSGDDIDDIGNSMLLSNNTPFTTYDVDNARRSDGYNCAETAGGWWFKTDGFCAGINLNEPWTIQNNVASRMSFRFRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A230</accession>
    <name>A0A3S1A230_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_000301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000004">
        <property type="protein sequence ID" value="RUS91899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A230"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS91899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="307" mass="35198" checksum="325DB9C78B91082F" modified="2019-04-10" version="1" fragment="single">MNILSRSCERSFSIPYSAYNTMGLVDQRKTAILIFEALEKLVSFLSDLNRALVAFIRQELEQLNAIIDEERDNNDYVNRVLLQRGNKLTQNLPDLLSDLPVHHQSYTNMTLCNADPDILAGGNPKDFHTDRQNNSRNCRSSRHYSNTQIISPSAPENNSHSNRCQTFRRQRRRSSAQMGINVNTYNYRCTIDCHPLHCTFCFEDGIMNHLNPHGRSKNDLVHAISDELDQDECDSNISSFQDIGRNSICIRCRLPEHECCNVHNNRFGNRLYENIPVSSHRNGAEQSNPLDDETVNEHRVPLHSQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A2W1</accession>
    <name>A0A3S1A2W1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_003018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000062">
        <property type="protein sequence ID" value="RUS89208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A2W1"/>
    <dbReference type="STRING" id="188477.A0A3S1A2W1"/>
    <dbReference type="OrthoDB" id="6163161at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS89208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="155" mass="17379" checksum="AA1762204D2C76EA" modified="2019-04-10" version="1">MSAPGTDEEEARTEVEVLDTEEVLPDGTIHHVHKVHRHSVKITHKSVSSEDGQTRVVDVKEDVPGTVRDDVLETFQERPHLEHDVEVVDEVRPDGSHVKHKLVLNRMVAHTHIHQESFDEGLGGRRKVSDFDTDEVVPGTESAFQEELEPSGDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A3W3</accession>
    <name>A0A3S1A3W3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Pyruvate dehydrogenase E1 component subunit beta</fullName>
            <ecNumber evidence="11">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_010108</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 15">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="11"/>
    <dbReference type="EMBL" id="RQTK01000301">
        <property type="protein sequence ID" value="RUS82134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A3W3"/>
    <dbReference type="STRING" id="188477.A0A3S1A3W3"/>
    <dbReference type="OrthoDB" id="10266385at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000006">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027110">
        <property type="entry name" value="PDHB_mito-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006667">
        <property type="entry name" value="PRK09212.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008854">
        <property type="entry name" value="PRK11892.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624">
        <property type="entry name" value="DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624:SF96">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="9 11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="12">
        <location>
            <begin position="35"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS82134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="362" mass="39221" checksum="8E9667EFCADCBD3A" modified="2019-04-10" version="1">MATLCKTISSVTRSATKLNQFSRLLSTSQRCSVQMAVRDALNTAMDEEIERDEKVFILGEEVGQYNGAYKVTKGLWEKWGDKRVMDTPITEMGFAGIAVGAAMAGLRPVCEFMTFNFSMQAIDQVINSAAKTYYMSAGQVPVPIVFRGPNGAAAGVGAQHSQCFASWYSQCPGLIVASPYSSEDARGLLKAAIRNENPVVFLENELMYGTSFEVSDEALGKDFLIPFGKAKIERAGSHITLVAHSKSVGLCLEAANELVGQGVECEVINLRTLRPLDDQTIIESVMKTNHLVTVESGWHHCGIGAEVVALVMESPAFNYLDAPVLRVTGADVPMPYAKSLEDLALPQVKNVLTAVRKSLNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A4X6</accession>
    <name>A0A3S1A4X6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_009459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000271">
        <property type="protein sequence ID" value="RUS82795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A4X6"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS82795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="132" mass="15773" checksum="F9C01315D9F35B56" modified="2019-04-10" version="1">MLVYRTEIQTRSLRTLWGRTFSRFFSYRLTTNYETASYRRRTLITSSRQGQARCVVISVSTLNKTIHRKWRRSLPCDAMRCVYGYGKYHSVVTFSRRNSHCVITTKSVGLLFHDWQLLMFREKIENKITSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AGT0</accession>
    <name>A0A3S1AGT0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_000636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000008">
        <property type="protein sequence ID" value="RUS91663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AGT0"/>
    <dbReference type="STRING" id="188477.A0A3S1AGT0"/>
    <dbReference type="OrthoDB" id="2156856at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11378">
        <property type="entry name" value="DUF296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.80">
        <property type="entry name" value="Hypothetical protein, similar to alpha- acetolactate decarboxylase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005175">
        <property type="entry name" value="PPC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34988:SF1">
        <property type="entry name" value="DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34988">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03479">
        <property type="entry name" value="PCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117856">
        <property type="entry name" value="AF0104/ALDC/Ptd012-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51742">
        <property type="entry name" value="PPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPC" evidence="1">
        <location>
            <begin position="15"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS91663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="148" mass="15701" checksum="B1C4C699C1277D98" modified="2019-04-10" version="1">MSCAEIETNVLSKQCGALQCYPLRLCPGEELQTTLAQFVRSRGLEAAFVLSCVGSVTKAHLRMANSTDTKLYTQGPYEIVSLVGTLSGGSSGHLHTSLSDAQGEVVGGHVLGQMVVHTTAEVVIGNVQGLVFTREPDSRTGYDELCVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AZQ8</accession>
    <name>A0A3S1AZQ8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_015961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000675">
        <property type="protein sequence ID" value="RUS76289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AZQ8"/>
    <dbReference type="STRING" id="188477.A0A3S1AZQ8"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF176">
        <property type="entry name" value="ARRESTIN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="200"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS76289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="409" mass="46708" checksum="F0E518E90CB945E3" modified="2019-04-10" version="1">MICCGTNAPMQHNHDKSGTSAYLELSLEQADLVYYSGDRIRGALIVHVAAPVTIAGVELRFRGAAWAKWREIGTEGSRKTEVEHEKEEIYFDDRFCLWGKVADDSRWESREVLNRGRHLFPFQYKLPDGIPCSFEGPDASIRYTIHGALVRVAGANIITNKIVTVLRDLDVKKDSEKKSPTSRHILEDHAERTFSTTCCRPSRVSCSLCVPKRSFVPGETIHADVQIHNMTMKKSGVCRLQLKQLVTYDESHCRPILLEELEFHEGMRPGQRRQWNSLNMVVPATCPSRLSKCRVIDVRYCVAIECQFSDSVLYAAVPITIVTVPERGIIPVRWSYQECVQDYTEGNEEETSTDEVFRPKYKFFEELKDIRKDKYFILKLRQSPGIKRRLLGNEAESRADSEAVNESKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B1I5</accession>
    <name>A0A3S1B1I5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Adenosine kinase</fullName>
            <shortName evidence="10">AK</shortName>
            <ecNumber evidence="3 10">2.7.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Adenosine 5'-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_022603</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>adenosine + ATP = AMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20824"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 3 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.20" evidence="3 10"/>
    <dbReference type="EMBL" id="RQTK01001617">
        <property type="protein sequence ID" value="RUS69638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B1I5"/>
    <dbReference type="STRING" id="188477.A0A3S1B1I5"/>
    <dbReference type="OrthoDB" id="432447at2759"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004001">
        <property type="term" value="F:adenosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01168">
        <property type="entry name" value="adenosine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000006">
        <property type="entry name" value="Adenosine kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001805">
        <property type="entry name" value="Adenokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769:SF3">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00989">
        <property type="entry name" value="ADENOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 10" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="11">
        <location>
            <begin position="25"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS69638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="342" mass="37683" checksum="DAE0DC3F0E8E1766" modified="2019-04-10" version="1">MVEQGILLGYGNPLLDISVQATKDYLDKYGLEANNAILAEDKHKPMYAEMSEQFKDVEYVPGGAALNTTRVAQWLLQCPSATSFFGCIAQDKFGDILTKAAKSAGVDVKFQYTDKEPTGTCAVVCTDKNRSLVANLAAANCFSEDHLDVAQNWAQVEKAKFYYFAGYPLTVCPAAMLRIAKHAAEKNKVVCMNMSAPFLCTFFKEPMLQMLPYVDYWFGNETEADEFAKVNEFGTTDRKEIAKKMGTWEKVNKSRSRVVVITQGSDPVLVYTDGEVKEYPVIAIKSDSIVDSNGAGDSFVGGFLSQLVQGKSLTECIRCGHHTANIVLQRTGCTLPEKPTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B2K1</accession>
    <name>A0A3S1B2K1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_013885</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EF-1-beta/EF-1-delta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000515">
        <property type="protein sequence ID" value="RUS78365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B2K1"/>
    <dbReference type="STRING" id="188477.A0A3S1B2K1"/>
    <dbReference type="OrthoDB" id="331763at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005853">
        <property type="term" value="C:eukaryotic translation elongation factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00292">
        <property type="entry name" value="EF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.60:FF:000001">
        <property type="entry name" value="Elongation factor 1-beta 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036219">
        <property type="entry name" value="eEF-1beta-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018940">
        <property type="entry name" value="EF-1_beta_acid_region_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049720">
        <property type="entry name" value="EF1B_bsu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014038">
        <property type="entry name" value="EF1B_bsu/dsu_GNE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595">
        <property type="entry name" value="EF-HAND AND COILED-COIL DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595:SF21">
        <property type="entry name" value="ELONGATION FACTOR 1-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10587">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00736">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00888">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54984">
        <property type="entry name" value="eEF-1beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange" evidence="6">
        <location>
            <begin position="177"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="113"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="75"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS78365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="264" mass="28954" checksum="68CB94934BC6E61F" modified="2019-04-10" version="1">MANPLLLENVWLQQQKFEDAERLYQQLKAGTTSASQTNTENKCTLAGEIAQVRQDIQSALNKPPLQGSPASGVVDAAVMKRLEALEKENKELRKITDDLRALILTVRSSVEGGAAPASAPASSAPPKKPAPADDDDDDDLDDEDLFGSDDEETKAIKEKRLAAYAEKKAKKPVIIAKSSVLLDVKPWDDETDMVELEKKVRSIEQDGLLWGASKLIEVGYGIKKLQIMSVIEDDKVSVDDLQEKITTDFEDLCQSVDVAAFNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B365</accession>
    <name>A0A3S1B365_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_021417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001327">
        <property type="protein sequence ID" value="RUS70825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B365"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS70825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="120" mass="13311" checksum="EDE9A276E943FBA3" modified="2019-04-10" version="1" fragment="single">ADVFGGVNLEGLELGDGFLEGTDFSHHAHYFVCLLTLDVKLTGGGEERTCLHRKLELGGPEHEELPPGLLQQQDLVSERQSRERGHRLGPLDRHEQQARSRLADRLGVVGVAQEQLVRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B4Z4</accession>
    <name>A0A3S1B4Z4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1899 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_017121</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000770">
        <property type="protein sequence ID" value="RUS75114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B4Z4"/>
    <dbReference type="STRING" id="188477.A0A3S1B4Z4"/>
    <dbReference type="OrthoDB" id="1850764at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF44">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF1899" evidence="4">
        <location>
            <begin position="4"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="351"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="449"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="721"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1166"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="366"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="381"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="409"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="524"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="739"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="812"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="840"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="873"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="980"/>
            <end position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS75114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1201" mass="129938" checksum="A56EE44C5E7D00C0" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B6C0</accession>
    <name>A0A3S1B6C0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_011356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000368">
        <property type="protein sequence ID" value="RUS80885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B6C0"/>
    <dbReference type="OrthoDB" id="10622740at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS80885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="240" mass="25200" checksum="5DBA9C2ED380730B" modified="2019-04-10" version="1" fragment="single">MADSNSGENSPISRDLELSDPGQKLLRPSDSTSAAASASSSKTSYSSSSFSSSSSSSFSVSSSSSQSQCSSSSASSATSQSTVKYRTSMLYAEDPGPVRRKSLDLGKSTEPDAPGRRRHNTDMDEMEEELMRPVADGEDAVLGESASSLSSTQSSSGEASPSQAAIQRIASSSSLRKSGASDPYKALERSQSDASLMRDLILLDAEDVHLTAAESSSGQNISECNRVYLDLSRAEAFEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B7J5</accession>
    <name>A0A3S1B7J5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein quiver</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_010576</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000325">
        <property type="protein sequence ID" value="RUS81659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B7J5"/>
    <dbReference type="OrthoDB" id="6083863at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032222">
        <property type="term" value="P:regulation of synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030431">
        <property type="term" value="P:sleep"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031424">
        <property type="entry name" value="QVR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050975">
        <property type="entry name" value="Sleep_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562">
        <property type="entry name" value="ATILLA, ISOFORM B-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17064">
        <property type="entry name" value="QVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS81659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="29457" checksum="6ECA035C76EF771D" modified="2019-04-10" version="1">MRANWGYPFYAKSGRSTDMRKGAEVELDQVLPAITMWTLDIRLLILATLFSLARRRLPVGDSLLCYRCDNLSNPPCNQYFMAYQFRAITCPMKSNGDRPMCGKQPLPVGDSLLCYRCDNLSNPACNQYFMAYQFRAITCPMKSNGDRPMCGKQQQPPLRNGWVGVLRSCYYPGDLPDMNETLGCHHHMIVDTNFSAIYCLCDRDLCNGAKSTLSGRHFRGSGSHWWFSTHALSYLLTLLTSSVACPILLAGCAFARVLLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BC92</accession>
    <name>A0A3S1BC92_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_011600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000380">
        <property type="protein sequence ID" value="RUS80650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BC92"/>
    <dbReference type="OrthoDB" id="10664475at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS80650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="336" mass="36405" checksum="0BC66A8C40DBF0AD" modified="2019-04-10" version="1">MMSPVELQQLWKEVSSMSSMHSGVDEHLLKAANGVHGSAPFPGSGANPASSSSASSSLPTASSSYSSAASSSAAGHGSNSGYHNNNNNNNSSNNNNNAVTSNGGSYDLSRRRNSSSPIHFPPHPHHHHQQQQHHHQQHQRHLGQVHSRSINGSASPGPSTPYMNGDAEGHGLSGRDDQANKASVTNLHPTPNKVKNKEGPGDRNVSGSLRWSNRNIRESLPPMFSNRDPLQPFVIFRDDVTPLFSANPSLRWPKMLEMCCESLHLEGRGSSRRPYACKEHEGAELIYVSTGHIVALCEDPVVPSRRLCFLCLHGPGWCLCRTRLAQIPAYIGLDVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BE38</accession>
    <name>A0A3S1BE38_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_010386</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000317">
        <property type="protein sequence ID" value="RUS81863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BE38"/>
    <dbReference type="OrthoDB" id="6103133at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032727">
        <property type="entry name" value="CLAMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28457">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28457:SF2">
        <property type="entry name" value="SIMILAR TO 4930578I06RIK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS81863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="167" mass="19429" checksum="15D95690BE3453A3" modified="2019-04-10" version="1" fragment="single">MCFKMNTQKSHHHIATKMATHGKSDGSKNMLTEKDIKEITALQVDDAKELLSKKLKLSPYLDPNDLQKAPFITFLYENISFASEKGFPLMHIGLVVKFAHEYLKRILVKDHRLADAVKDFKELAEIIAPLNDRHKQQYTDFIHQTVLCHYNLYKYVFSHLRDIVCPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BF63</accession>
    <name>A0A3S1BF63_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_005364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000125">
        <property type="protein sequence ID" value="RUS86885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BF63"/>
    <dbReference type="STRING" id="188477.A0A3S1BF63"/>
    <dbReference type="OrthoDB" id="8918678at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402">
        <property type="entry name" value="RGPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402:SF6">
        <property type="entry name" value="SECRETORY 16, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS86885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="209" mass="21428" checksum="DC7454B3B334C13B" modified="2019-04-10" version="1">MILPDDKDPAIVWDPTKKKWVNADGTEDETQSAAPPPTDSDLMGKPPSGGPPLSNSTGLTGGGAPPPMQAGSGANRFSLKAKGARNQYVDVNNPKPVAVPSNLFNVMPGAPPVGNAALPQVLMPGAAPPTDGSQMDSNTNSSQGLLSVPENDQPPPAADVTVNNSAPPQLPQLPQMPMMFNPASLKGNQGSAASAGTGMKYGQRRAYPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BF64</accession>
    <name>A0A3S1BF64_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase M12B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_012867</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000455">
        <property type="protein sequence ID" value="RUS79376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BF64"/>
    <dbReference type="STRING" id="188477.A0A3S1BF64"/>
    <dbReference type="OrthoDB" id="2149267at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051489">
        <property type="entry name" value="ADAM_Metalloproteinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702">
        <property type="entry name" value="ADAM10/ADAM17 METALLOPEPTIDASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702:SF2">
        <property type="entry name" value="KUZBANIAN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13688">
        <property type="entry name" value="Reprolysin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="596"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="5">
        <location>
            <begin position="166"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="4">
        <location>
            <begin position="397"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS79376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="718" mass="79953" checksum="0C0C2176DCFC06D9" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BFK2</accession>
    <name>A0A3S1BFK2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Acetoacetyl-CoA synthetase</fullName>
            <ecNumber evidence="2 7">6.2.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_005102</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Converts acetoacetate to acetoacetyl-CoA in the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16117"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.16" evidence="2 7"/>
    <dbReference type="EMBL" id="RQTK01000118">
        <property type="protein sequence ID" value="RUS87170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BFK2"/>
    <dbReference type="STRING" id="188477.A0A3S1BFK2"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05943">
        <property type="entry name" value="AACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005914">
        <property type="entry name" value="Acac_CoA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01217">
        <property type="entry name" value="ac_ac_CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002937">
        <property type="entry name" value="PRK03584.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921:SF1">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="9">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="8">
        <location>
            <begin position="62"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS87170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="627" mass="69703" checksum="D51343B300EB617C" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BGZ1</accession>
    <name>A0A3S1BGZ1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_011721</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000387">
        <property type="protein sequence ID" value="RUS80500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S1BGZ1"/>
    <dbReference type="OrthoDB" id="10032537at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
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</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BH98</accession>
    <name>A0A3S1BH98_ELYCH</name>
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        <recommendedName>
            <fullName evidence="13">Cytochrome P450</fullName>
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        <name type="scientific">Elysia chlorotica</name>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">EC2010</strain>
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            <name>heme</name>
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    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
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    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
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    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:xenobiotic metabolic process"/>
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        <property type="entry name" value="Cytochrome_P450_fam2"/>
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        <property type="entry name" value="CYTOCHROME P450 306A1"/>
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        <property type="entry name" value="CYTOCHROME_P450"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="27"/>
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    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
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            <begin position="310"/>
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        <location>
            <position position="488"/>
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        <ligandPart>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS83909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
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    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="60907" checksum="B41E72F05B308534" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BHD4</accession>
    <name>A0A3S1BHD4_ELYCH</name>
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        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_003907</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="RQTK01000086">
        <property type="protein sequence ID" value="RUS88336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BHD4"/>
    <dbReference type="STRING" id="188477.A0A3S1BHD4"/>
    <dbReference type="OrthoDB" id="249932at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042078">
        <property type="term" value="P:germ-line stem cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22655">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE TDRD12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22655:SF2">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE TDRD12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Tudor" evidence="10">
        <location>
            <begin position="217"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="11">
        <location>
            <begin position="702"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="837"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS88336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="876" mass="99687" checksum="95944D68FCF24508" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BIT6</accession>
    <name>A0A3S1BIT6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ETS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_002913</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ETS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000059">
        <property type="protein sequence ID" value="RUS89306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BIT6"/>
    <dbReference type="STRING" id="188477.A0A3S1BIT6"/>
    <dbReference type="OrthoDB" id="10067219at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000039">
        <property type="entry name" value="Friend leukemia integration 1 transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF304">
        <property type="entry name" value="DNA-BINDING PROTEIN D-ETS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00345">
        <property type="entry name" value="ETS_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETS" evidence="7">
        <location>
            <begin position="189"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="125"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="303"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="333"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS89306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="372" mass="39675" checksum="19AD04421AC2B758" modified="2019-04-10" version="1" fragment="single">LSPTITVSLPFPEEPVESVPNKDRSGSLDYIGTSPLGDSFKQPPSYEEYIKAHNSNTTVILPSPTLGCTDTTSQCSDTNTGTENEAGACVAMETTVDSLVKSGADEHVPSNLLDDIMECIQLEAGADDKSDDSQLDSINGDSNMPGSGEATPAKQEVTSGNTSPTLPKTEDNDKMREIAAAVLAGSGQVQLWQFLLELLTDPGNESCIRWLGKGGEFRMVDPEEVARRWGRRKNKPNMNYDKVSRAMRYYYDKMILSKVHGKRYTYRFNFGVIMRAQRPAQTPTDPAELAELLNIISSSSSVATTSGSSAHAQAHVPTPASATVAGNPRSGESHSPSHYAPTSGNPGVVSRAGGNGIGNSSVSMDDSAFGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BIV0</accession>
    <name>A0A3S1BIV0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">OBG-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_002870</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000058">
        <property type="protein sequence ID" value="RUS89350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BIV0"/>
    <dbReference type="STRING" id="188477.A0A3S1BIV0"/>
    <dbReference type="OrthoDB" id="347018at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="entry name" value="GTP1/OBG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702:SF43">
        <property type="entry name" value="GTP-BINDING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="Obg GTP-binding protein N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="4">
        <location>
            <begin position="11"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="147"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS89350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="40992" checksum="B2902B80B7125F47" modified="2019-04-10" version="1">MSYMIPKSRVPAFVDFLQIRACGGAGGQGLPKFGGFGGDGGKVIVVAKKKIKTLKQVLQKYPRQMCKAPTGQNSDKFHLLGENGGDITIQVPVGVLVHKHDGSIVDLNQENELCVVAHGGVGGNHTTNFLGVKGDENLIGLELKLLADVGLVGFPNAGKSTFLKAISKAKPKIAAYPFTTISPQLGQMEYDDGRMISVADLPGLIEGAHQNYGMGIKFLRHAERTKLLLYVLDINAFQLSHKYPERSPFETLLLLNKELDEYGHGMLEKPSILAINKIDTDASGRSLARLMDLIKNLPASLDQVSEDLHPSHLAQFDEILTMSALNNSGLVVIKDKIREVMDVQAELQRTEELAKTKTLSQIGNIHKEQNKRRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BNN3</accession>
    <name>A0A3S1BNN3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_021001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001249">
        <property type="protein sequence ID" value="RUS71236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BNN3"/>
    <dbReference type="OrthoDB" id="6271941at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS71236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="119" mass="13280" checksum="68A61B6E9A025F07" modified="2019-04-10" version="1">MTFFEATVACDVVDGKLPQILSPEDQTRLEKFLSSAGAGVSTNIWLGATDLQQEGTFRYISRDNQDAISAWSHWAPGYPHTDRTSNCAVINLANGWRWQDSICSYHLQVMCEVVLRQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BPZ8</accession>
    <name>A0A3S1BPZ8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_006275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000155">
        <property type="protein sequence ID" value="RUS85946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BPZ8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS85946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="335" mass="34545" checksum="794AC84FC30CD379" modified="2019-04-10" version="1">MLDTDSDTEVNLDPDSEAVGELDPDSEAVGDMDPDSEAVGDMDPDSDSVAGIDPDGDPVGDTDPDGDAVGDTDLDSATVPNAVPDSDAVGNGDADSDAASSVEPYIDAVGELDSKSDSFAAESGSLGMPVPTDRALRMFGCAVIVGSKIGDDGVCDAVANNTELDPATVDPIEERTRPVAVKPTVVVEMDPDSDGVANIDADCKSVAIVEPDSDSVADMDIDADGVVSIADMDPDSDPVPDMDPDTTYVAVKDPDSSDVAIVDPDRDASGSVDWESDPFGTKLAFLRMRLRTDLTWRMFGCALIVDSKIGKVDDGAVSDSSVVDTGSIDSVEDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BR32</accession>
    <name>A0A3S1BR32_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Receptor ligand binding region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_002742</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000054">
        <property type="protein sequence ID" value="RUS89509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BR32"/>
    <dbReference type="STRING" id="188477.A0A3S1BR32"/>
    <dbReference type="OrthoDB" id="10065302at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017046">
        <property type="term" value="F:peptide hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052612">
        <property type="entry name" value="ANP_Clearance_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44755:SF11">
        <property type="entry name" value="ATRIAL NATRIURETIC PEPTIDE RECEPTOR 3 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44755">
        <property type="entry name" value="NATRIURETIC PEPTIDE RECEPTOR 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Receptor ligand binding region" evidence="5">
        <location>
            <begin position="98"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS89509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="231" mass="26048" checksum="4EAD6CDC0D69AD5F" modified="2019-04-10" version="1">MKTRKFRASSVPRIPSTTLFILVAAFVLSLAQDDHFFDKASVGVLPDQSVDRALDTGQVSGLVPLRTLAINPGTRRPVNVLLLVPYNNSIPWAYRKIMPALEIALQRIDADQVLPNHYLRMRYFDSKCDDSHSMNYAINAYMDKKGDAFFGPCCDYALAPVSRQATFWQVPLLTVGAEAPDFLTFKFQKFRTLTRAGPKNLQDVSDFLIMMIKSFHFTKMSIVSLVFVTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BSV1</accession>
    <name>A0A3S1BSV1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_004250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000095">
        <property type="protein sequence ID" value="RUS87972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BSV1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS87972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="276" mass="29183" checksum="6ACC6F0CADE4B603" modified="2019-04-10" version="1" fragment="single">KKFLGDEAVELLLVALEELWSSEAAVAAGDGAGVGTRRSVDQLVALQGSRRFECLFTRLASKWSCQANLAVPAHVILGGEELAAVWALELFALHSVHVLVVLVQVRLVVGAVLAQLTLELLGLVREVGVVVHLGAVLEDLLTHSTLVGRGALALAGVLLYADLVTLDVAVADLAELEVQLVTVVLQHMLAQRQPRLRHKGASGAREDAVGEQVPVERGLLGASVAAVRALVWHVHLHLVHLLHVPAEGGAASRLVLALVALHKVQALLVAAHRLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BXC7</accession>
    <name>A0A3S1BXC7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small monomeric GTPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_001078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000017">
        <property type="protein sequence ID" value="RUS91165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BXC7"/>
    <dbReference type="STRING" id="188477.A0A3S1BXC7"/>
    <dbReference type="OrthoDB" id="265044at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS91165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="21425" checksum="6B99E807BFFC67CE" modified="2019-04-10" version="1">MFCFRKDKSKTNMDAQSVRHRVYDLRVALVGDSDVGKTSISRVFTGDDKLKVKARPTIGYEFGFALRRYANGDSVRYIVVDTAGQERYSHALPNYMRDSDAVVLVYDVCVREGKKKAESHNMYFLESSAITGQQVHRIFDYLATEIRDRKLHELFHGTKKRLSQMAFKLPRPDQEEKKTGCQNCLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BXP7</accession>
    <name>A0A3S1BXP7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EGW08_014653</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">EC2010</strain>
            <tissue evidence="15">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000570">
        <property type="protein sequence ID" value="RUS77577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S1BXP7"/>
    <dbReference type="OrthoDB" id="6226898at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001228">
        <property type="entry name" value="Zinc finger protein 236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21549">
        <property type="entry name" value="PRDM2_PR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="14">
        <location>
            <begin position="39"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="832"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="858"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="897"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="923"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="960"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="986"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="1077"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="1103"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="1137"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="1163"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="1274"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="1334"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="1362"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="1390"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="196"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="260"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="339"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="547"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="627"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="781"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1839"/>
            <end position="1874"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1748"/>
            <end position="1777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="342"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="470"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1862"/>
            <end position="1874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RUS77577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1971" mass="217155" checksum="AC2E7A8D9334E2A8" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C938</accession>
    <name>A0A3S1C938_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitotic checkpoint protein BUB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EGW08_005951</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">EC2010</strain>
            <tissue evidence="17">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the WD repeat BUB3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000143">
        <property type="protein sequence ID" value="RUS86307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C938"/>
    <dbReference type="STRING" id="188477.A0A3S1C938"/>
    <dbReference type="OrthoDB" id="10262475at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000047">
        <property type="entry name" value="Mitotic checkpoint protein bub3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="13" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="11" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 16" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="93"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="240"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RUS86307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="330" mass="37152" checksum="3DF172294C758937" modified="2019-04-10" version="1">MADSPIEFKLSNMPSDGISAVKFGPNSSQFLLVSSWDETVRLYDVISDSQRFMYSHSAPVLDCCFYDAVHSFSGGLDKTLKMYDFNTSTDQVIGTHTAPIRCVEYAPDVNMVVTGSWDSTIKLWDPRSPTLVGTFPQLAKVILIIIIQTPLSKIVGTAGRRVLVWDLRNMGYVQQRRESNLKYQTRCIRSFPNKQGYVLSSIEGRVAVEYLDPNPEIQKKKYAFKCHRIKENGQELIYPVNAIAFHYGYNTFATGGCDGYVNIWDGFNKKRLCQFHRYPTSIASLAFSHDGSVLAIASSFTCEKEVDKSPAPDTVFIRNVTDQETKPKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1CB23</accession>
    <name>A0A3S1CB23_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_004360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000098">
        <property type="protein sequence ID" value="RUS87882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1CB23"/>
    <dbReference type="OrthoDB" id="6217024at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="346"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS87882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="430" mass="44897" checksum="0551E179852AD475" modified="2019-04-10" version="1" fragment="single">MINGKAQSIPQTSFTNGNFQPTRKLPVEGKVSTGLKQNTPTSSGNTTIVVGKPKIPQKPPKLGALEGFIGNSPSVEEDLNTGVNSATNASTAQLEDSKPPLVRLTSFTADSEDAILPFIEKTPVLSPDSIKRHVERSINPASQAPQVPVHALNAFDNSSTSTHDKASNPNPNSVRTKSDSTTQNFFPSSVKTDGKLSNTDTYSARTKREVSPAYNSRVSPSSQKKSLPFDESSGPQSPVPPPLPPRPTLPSLGKTQAPVTLKPTLSGGVNPGMSKSASGAIKPLLALSPKPGVANSNGFRSPGISDTCGSKEFYFGYDSSISTTTTSIPLPPPPPPPPPPPPPLLLLPLSPSTISSLKPQQINQPPRASSPPLPPPSPSLVNSMPTPPPSPPSLKTVNTVKPSNFSHTPLPLPPSPPPPPPPPPPAQDKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1CFY9</accession>
    <name>A0A3S1CFY9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_000602</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000008">
        <property type="protein sequence ID" value="RUS91629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1CFY9"/>
    <dbReference type="STRING" id="188477.A0A3S1CFY9"/>
    <dbReference type="OrthoDB" id="497880at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF26">
        <property type="entry name" value="MFS-TYPE TRANSPORTER SLC18B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS91629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="149" mass="15667" checksum="B92A058679AFDE5C" modified="2019-04-10" version="1" fragment="single">MVGIVFSSYEFVNFMMTPVFGNFVSEIGPKFMYAAGISVAGSCSVLFGFLDQGPGGLTFIAMSLLVRIVEALGMSAFSTSSFAIISAEFPNHISSVFSLLETFIGMGLLVGPTIGGSLYELGGFGLPFWVTGVLIMSTGILFFGCLPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H475</accession>
    <name>A0A3S1H475_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_020363</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001147">
        <property type="protein sequence ID" value="RUS71872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H475"/>
    <dbReference type="STRING" id="188477.A0A3S1H475"/>
    <dbReference type="OrthoDB" id="6161632at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS71872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="352" mass="41173" checksum="5CAF4CA2614FD84F" modified="2019-04-10" version="1">MFPVFEELCYKNEQTSTTVITVNKVKQRRSRREEDEAEFHSYSYQYQLLIAEDSLSKTQICFKAVLSIFGITKSRLERIQKALTSTGLPPIDGRGKHGNRPRAFTDVKIQSIIDHIRSFRGRQSHYTLRDSKKLYLPEELNVTKMHEMYMAEHPGETCSRESYRRVFVEKFNVTFGYPRKDTCSSCDSFKVELSKELPADELRRLAAERELHWRKSQVFYERKTAAAQEAQSSLQHAAAAFDFWKNFQCPNISTNDVYYKRQLSLFTFNVHDLGTGEVHLFPYDETVGRKGANDMASMLLFLFNEILPKEVTHLQLFCDSCPGQNKNWTMLRFLHFMVHTKKRFDTSSSPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H7A0</accession>
    <name>A0A3S1H7A0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_018587</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000913">
        <property type="protein sequence ID" value="RUS73655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H7A0"/>
    <dbReference type="STRING" id="188477.A0A3S1H7A0"/>
    <dbReference type="OrthoDB" id="6091075at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF133">
        <property type="entry name" value="POLY(A) RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="8">
        <location>
            <begin position="64"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="7">
        <location>
            <begin position="320"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="458"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="500"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS73655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="522" mass="57861" checksum="B0FE8E2A6A6DE538" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HJ40</accession>
    <name>A0A3S1HJ40_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">1-phosphatidylinositol-3-phosphate 5-kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_011772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000390">
        <property type="protein sequence ID" value="RUS80456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HJ40"/>
    <dbReference type="STRING" id="188477.A0A3S1HJ40"/>
    <dbReference type="OrthoDB" id="158357at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000285">
        <property type="term" value="F:1-phosphatidylinositol-3-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052810">
        <property type="term" value="F:1-phosphatidylinositol-5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032438">
        <property type="term" value="P:melanosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090385">
        <property type="term" value="P:phagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903426">
        <property type="term" value="P:regulation of reactive oxygen species biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000007">
        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043548">
        <property type="entry name" value="PIKfyve"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46715">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46715:SF1">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="909"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="972"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="917"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="933"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="972"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1004"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1025"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1055"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1066"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS80456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1066" mass="116292" checksum="91BAB8CF67F7E3ED" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HPY0</accession>
    <name>A0A3S1HPY0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_008414</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DENND6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000228">
        <property type="protein sequence ID" value="RUS83833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HPY0"/>
    <dbReference type="STRING" id="188477.A0A3S1HPY0"/>
    <dbReference type="OrthoDB" id="10265409at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024224">
        <property type="entry name" value="DENND6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13677">
        <property type="entry name" value="LD41638P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13677:SF0">
        <property type="entry name" value="LD41638P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="2">
        <location>
            <begin position="28"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS83833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="569" mass="64987" checksum="31BD72C4A12FE3B0" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SIA4</accession>
    <name>A0A433SIA4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_023593</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01002147">
        <property type="protein sequence ID" value="RUS68645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SIA4"/>
    <dbReference type="STRING" id="188477.A0A433SIA4"/>
    <dbReference type="OrthoDB" id="6155266at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS68645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="536" mass="60580" checksum="F0A1355C8046EAB1" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SJS1</accession>
    <name>A0A433SJS1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_022923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001732">
        <property type="protein sequence ID" value="RUS69317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SJS1"/>
    <dbReference type="OrthoDB" id="10545191at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS69317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="223" mass="24300" checksum="C8E82016764223FF" modified="2019-05-08" version="1">MTTDGSGVVGRRRRGTGASATPCICRPDATLMQDAANSKRELNVDLSWIGNSLDDKDSLEVCVLTTWPHDVTRSHAHLGAKCTGVQIKRNRREMRALGLATPQGDLINIDLVYGGRARRDLPRVDYSGMAAPQRRARGRRARRDFMDLDICQQHGSLEVWLSPPPVAVAPSPEPVPNRMDESPQQHGSLEVWLSPPPVAVAPSPPVAVAPSPEPVPNRMDESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SKJ7</accession>
    <name>A0A433SKJ7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_022567</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily. Omega family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001610">
        <property type="protein sequence ID" value="RUS69662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SKJ7"/>
    <dbReference type="STRING" id="188477.A0A433SKJ7"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS69662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="128" mass="14824" checksum="6056954AED4E987B" modified="2019-05-08" version="1" fragment="single">MKVTLYTAKYCPYSLRARIALAEKKMSMEIVESGDLAPEMLKKVSPSGTFPVLIEKDYSISNKRALLIYIDERFPAPSLLPSIVNERIKVRQSMDKIDELWYPLLDQIRENRTNKAKLKTLFQDVKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433ST35</accession>
    <name>A0A433ST35_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyltransferase 2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_019805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001068">
        <property type="protein sequence ID" value="RUS72426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433ST35"/>
    <dbReference type="STRING" id="188477.A0A433ST35"/>
    <dbReference type="OrthoDB" id="6082660at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF126">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS72426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="778" mass="86001" checksum="14F0C6A29659B8F1" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433ST83</accession>
    <name>A0A433ST83_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_019875</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001076">
        <property type="protein sequence ID" value="RUS72359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433ST83"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF20">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019304578" description="VWFA domain-containing protein" evidence="2">
        <location>
            <begin position="40"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="86"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS72359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="288" mass="30782" checksum="4571F94EA7346503" modified="2019-05-08" version="1">MASPRVCNHRISHGAPRRNFPAFAPLLVFLCCAVGGASGGIVHHDPGDIQDSYSLFNLLNNYVLSEPQSGTGIMTQLQIVTECPPNVIFVLDGSGSISFSGFETAKEAVIREIEALTASFAKVDVGVVLFSETNLVIPLQTRTSAQVSELIQQIRTLSHPRLGTELNEAIRVARRALAAYSINADRALNGDKSGNILVLFTDGQVEPEIEALSAQEVTTAQSKGILVLIDTVEEPSKTVQNIAPTVLESRTPINWVDFVACPRVTLDPPPKGSGATLEPPPKGSGLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433STK1</accession>
    <name>A0A433STK1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_019612</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001042">
        <property type="protein sequence ID" value="RUS72614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433STK1"/>
    <dbReference type="STRING" id="188477.A0A433STK1"/>
    <dbReference type="OrthoDB" id="1696654at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050573">
        <property type="entry name" value="SDH/FRD_Iron-Sulfur"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921:SF29">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] IRON-SULFUR SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS72614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="112" mass="12885" checksum="712389643751A55C" modified="2019-05-08" version="1" fragment="single">MVLDGLIKIKNEMDSTLTFRRSCREGICGSCAMNIDGTNTLACLYKINDNPRKAVKIYPLPHMYVVKDLVPDMSNFYAQYRSIEPYLKKKDVKEEDIGKQSYLQSVQDRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SVG5</accession>
    <name>A0A433SVG5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fumarate hydratase</fullName>
            <ecNumber evidence="2">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_018972</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="RQTK01000957">
        <property type="protein sequence ID" value="RUS73264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SVG5"/>
    <dbReference type="STRING" id="188477.A0A433SVG5"/>
    <dbReference type="OrthoDB" id="1738025at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01362">
        <property type="entry name" value="Fumarase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000002">
        <property type="entry name" value="Fumarate hydratase class II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00979">
        <property type="entry name" value="fumC_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008909">
        <property type="entry name" value="PRK12273.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444:SF1">
        <property type="entry name" value="FUMARATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="4">
        <location>
            <begin position="20"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarase C C-terminal" evidence="5">
        <location>
            <begin position="417"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS73264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="484" mass="51964" checksum="9E1BC4EFD6EA7A62" modified="2019-05-08" version="1">MTDEIGKNLAGFRLETDTFGDINVPVDKYYGANTARSLINFNIGGPSEIMPIAIIRAFGILKKCAAQVNEEFGLDSNIANLIVKAADEVIAGKLDDSFPLVIWQTGSGTQSNMNVNEVISNRAIEMTGGVMGSKKPVHPNDHVNMCQSSNDTFPTAMHIAVAQECTSRLIPAIDSLAAGFESKSKEFDSIIKIGRTHLQDATPLTLGQEFSAYHQQVLNAKDRIKATFPRLMELALGGTAVGTGLNTKRGFAEKAAAKLADATGIPFVPAKNKFEALAAHDAMVEFHGALNVFACSLMKIANDIRLLGSGPRCGIGEISLPENEPGSSIMPGKVNPTQCEALTMVAAQVMGNQTAITIGGSQGHFELNVYKPLIVSNVLRSIRLLSDACVSFNTHCLQGITANEDRIQYLRDNSLMLVTALNPHIGYDNAAKIAKNAHREGISLKESALALGLLTSEQFDSWVKPENMLGPEVWVKPENMSGPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SVH5</accession>
    <name>A0A433SVH5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_018946</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000954">
        <property type="protein sequence ID" value="RUS73297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SVH5"/>
    <dbReference type="OrthoDB" id="6162106at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050801">
        <property type="entry name" value="Ca-Dep_Lectins_ImmuneDev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801:SF63">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801">
        <property type="entry name" value="LITHOSTATHINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019215952" description="C-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="42"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS73297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="183" mass="20211" checksum="398F7699F2005377" modified="2019-05-08" version="1">MCAVALLCLLAITGAVSGSGTIEDSCPAALLGRVDIYYLQVWESSCFYFGLSDKKSYSAASAFCKEDGGTLAMPKSKSLNDFLTNQVVSYYGVGGEFVWIGLDDKKNESAFIWADDTKMTWDNFAPQNGPSNIWIVRDTEDCAAMDDQGLWHDHRCVDNQVLSWAGWANSAMFFICQYTIGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SWW9</accession>
    <name>A0A433SWW9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_018443</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000898">
        <property type="protein sequence ID" value="RUS73804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SWW9"/>
    <dbReference type="STRING" id="188477.A0A433SWW9"/>
    <dbReference type="OrthoDB" id="10063139at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000003">
        <property type="entry name" value="Protein CBG25708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000063">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000026">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="8">
        <location>
            <begin position="47"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="9">
        <location>
            <begin position="603"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS73804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="849" mass="95965" checksum="E185119CD05A10F8" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SXI8</accession>
    <name>A0A433SXI8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_018209</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000874">
        <property type="protein sequence ID" value="RUS74035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SXI8"/>
    <dbReference type="STRING" id="188477.A0A433SXI8"/>
    <dbReference type="OrthoDB" id="5975336at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238:SF69">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="304"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="53"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="266"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS74035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="387" mass="45010" checksum="618C4B2752ACEB45" modified="2019-05-08" version="1" fragment="single">MKETYNQMILQYMINSSSTNFNFREPYIKRSLIYVYPLFMLLHAIVCLAGIISNVAMVVVIIRRRLYQDQTFVLFINLAFADLIKCVFVMPMTLANLLIQNWLFGSFLCFFMPMLQYFPVHATMLTFLTIAIDRYRMIVQPFKSRVQASLCIIAIWVGSVCLVLPFAIYIKYIDLKATLGEEFDGVGLCTVRVERRIEEYIRAMFVTLYAMPLATMALLYVRISAEMKSKESATSRPLSVHFSPISTSTEVDLDRSSMLHHHHNHAWSPVLEPPSPPTRQHRQESTQGSDNDLNLPRERRTQNYLITMNTLFAVCWCPSHILVLVNYFVHETDNNVGHYDVTYMLFTWFGFLSTCTTPVLFMSWVMSDAAKDRLRGYFRFSNRRRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SYH0</accession>
    <name>A0A433SYH0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="18">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">EGW08_017882</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">EC2010</strain>
            <tissue evidence="22">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 18">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine(out) + ATP + H2O = a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66036"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:22801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:66037"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="18"/>
    <dbReference type="EMBL" id="RQTK01000839">
        <property type="protein sequence ID" value="RUS74359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SYH0"/>
    <dbReference type="STRING" id="188477.A0A433SYH0"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140327">
        <property type="term" value="F:flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000054">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000009">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000023">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF218">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 17 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 16 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 18" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="450"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="970"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1046"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1078"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1106"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1142"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="20">
        <location>
            <begin position="33"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="21">
        <location>
            <begin position="950"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="773"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="15">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="558"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="601"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="625"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="665"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="745"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="746"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="747"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="871"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="877"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="897"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="900"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="901"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="901"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00050913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="RUS74359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1167" mass="131154" checksum="7908FAC9AC08C089" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SYR6</accession>
    <name>A0A433SYR6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_017779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000829">
        <property type="protein sequence ID" value="RUS74463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SYR6"/>
    <dbReference type="OrthoDB" id="6075263at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS74463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="240" mass="26583" checksum="8C92F59132B86E9E" modified="2019-05-08" version="1" fragment="single">VLFAREWRGRFRQIGNALCWCRTRKEKHWLGPGADMCKLSLGVQDRRSECDLQLDDLEAPRPEHATTSGPYIARIMGEEGTPCCGRAIRSERSVRDKIQVFDASKPARAGRRVDRLLTQPRQGQNGSGAGQKSNLEAEETDPTKPRQAQQSNAQDNHHHHQHHHHHHHYLSPQQQAALKAGPSPRPGETASQALPCTAGCSVWSTSTPLSRQPACRSGPALVSLAPDVHYKLRPEMAAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T5F2</accession>
    <name>A0A433T5F2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="13">6.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EGW08_015478</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">EC2010</strain>
            <tissue evidence="15">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19713"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19714"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:36139"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:61526"/>
            <dbReference type="ChEBI" id="CHEBI:72745"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:36140"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA = 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52112"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:90718"/>
            <dbReference type="ChEBI" id="CHEBI:136408"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:52113"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA = 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52116"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:78832"/>
            <dbReference type="ChEBI" id="CHEBI:136409"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:52117"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65341"/>
            <dbReference type="ChEBI" id="CHEBI:136407"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:52109"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:15422"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:30751"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:30752"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="13"/>
    <dbReference type="EMBL" id="RQTK01000637">
        <property type="protein sequence ID" value="RUS76771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T5F2"/>
    <dbReference type="STRING" id="188477.A0A433T5F2"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047676">
        <property type="term" value="F:arachidonate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05927">
        <property type="entry name" value="LC-FACS_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045311">
        <property type="entry name" value="LC-FACS_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 13" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="14">
        <location>
            <begin position="94"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RUS76771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="700" mass="76804" checksum="7DC6908FFBAF0461" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T675</accession>
    <name>A0A433T675_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_015158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000612">
        <property type="protein sequence ID" value="RUS77075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T675"/>
    <dbReference type="STRING" id="188477.A0A433T675"/>
    <dbReference type="OrthoDB" id="6144727at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS77075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="513" mass="56009" checksum="B68CBFD5F78EE2FD" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T880</accession>
    <name>A0A433T880_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">rRNA methyltransferase 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_014455</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000552">
        <property type="protein sequence ID" value="RUS77791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T880"/>
    <dbReference type="STRING" id="188477.A0A433T880"/>
    <dbReference type="OrthoDB" id="270651at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18105">
        <property type="entry name" value="SpoU-like_MRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047182">
        <property type="entry name" value="MRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047261">
        <property type="entry name" value="MRM1_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46103">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46103:SF1">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="RNA 2-O ribose methyltransferase substrate binding" evidence="11">
        <location>
            <begin position="77"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="31"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS77791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="347" mass="38737" checksum="948B7BB4BB13FE62" modified="2019-05-08" version="1">MFNNKELRTMFRLSKHLFRIISQQEQSCSVKRASNYNAQKPDSQSQPRPKYNHGLSGKGKSKRLNKIQDLPKIQGEIVFGLHPVYLAIRAERRNKFHTLYVGEKFMDTENRNSAVSELLELAQHRNIMICPLRKPILDQLAGNRPHQGVCLDADQLEVPEWTFETEVSSSSQGMPIWLLLQSIQDPMNLGAILRTAYYLGLDKVVIPAVESCRLSPTVSKASAGALEVIDLVRLPKGVSETALCEWWQARGWQVVGTALDKKESTSSDSSLPQSLYKFSTSRPTMVLLGNEGTGLSPDLIQACDTLVTIPNYEQSHKGLPRISSLNVSVAAGILLHWIKVSSSKSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TA02</accession>
    <name>A0A433TA02_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LanC-like protein 3 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_013948</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LanC-like protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000520">
        <property type="protein sequence ID" value="RUS78284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TA02"/>
    <dbReference type="OrthoDB" id="10257263at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031179">
        <property type="term" value="P:peptide modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04794">
        <property type="entry name" value="euk_LANCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000012">
        <property type="entry name" value="LanC-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007822">
        <property type="entry name" value="LANC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020464">
        <property type="entry name" value="LanC-like_prot_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12736">
        <property type="entry name" value="LANC-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12736:SF7">
        <property type="entry name" value="LANC-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05147">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01951">
        <property type="entry name" value="LANCEUKARYTE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01950">
        <property type="entry name" value="LANCSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM01260">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158745">
        <property type="entry name" value="LanC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR607822-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS78284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="49565" checksum="5B9B0EA16054813C" modified="2019-05-08" version="1">MGPSVESALIYYVKTASRQPKLLKVLKIWIMPRRRFFRNQLPDHSPGDAVLIDKDWWHGQILALVQTVTEALSSNVSQEGGLYVGSAGIAYMLYYVSTYEPFYQHKANYIHIAQSIFKRDLTFTERQSSKPADRVSFLLGPSGLYTLGALLGKLSQKEDMVQDNINKFKAVASECIKPNFLGCGSDELFVGRAGFLSGALTLEKRIGIKVLDDDTINSICRAMVMSGAEYSKRKKSKSPLMYAYYDTEYLGAAHGLSSILQMIISCPSFLTADPQSAQVVRNSVDWLLSTQTPDGNFVPATDELVSSRSESEELVHWCHGAPGVVYLLAKAYLVWQDERYLQACIACAELTWNKGLLKKGPGICHGVAGSGYVFLLLYRLTDNKKYLHRAVQFGRFIFSEEFQAEAKTPDNPFSLYEGLAGTVCFMLDLLQPDRAEFPFFDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TBI6</accession>
    <name>A0A433TBI6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_013298</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000480">
        <property type="protein sequence ID" value="RUS78957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TBI6"/>
    <dbReference type="STRING" id="188477.A0A433TBI6"/>
    <dbReference type="OrthoDB" id="6435638at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032870">
        <property type="term" value="P:cellular response to hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241:SF59">
        <property type="entry name" value="ADIPOKINETIC HORMONE RECEPTOR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="161"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS78957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="312" mass="33906" checksum="427E5A2B0A05D6BC" modified="2019-05-08" version="1">MRTKHLQLSPARSCRGLFASGATLLSLLTTVLSAALASSVSQKQDSTAPSVDALSGAEPNASCYEVKMVVVRSSSSSMPLNATTSGMHGEGTNTLEKAMQPVGEDHNLYFNTYSELEVFCANLTFEEAANYSFCNGPLWLTDNNAVSVISYSCLLVIALCGNLTVFITLFRNRRHKSRINMFIMHLAIADLIVTFIILPLEIAWHATVSWWAGDLACRGLMFCRALGFYLSSCIVVSISLDRYLAIMRPFSIAAADTRAKLMLVISWGLSIVASIPQDGVQIMVACGNKNSRFNFNAPFGSRVGQDSANINM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TC12</accession>
    <name>A0A433TC12_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_013090</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MnmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000468">
        <property type="protein sequence ID" value="RUS79143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TC12"/>
    <dbReference type="STRING" id="188477.A0A433TC12"/>
    <dbReference type="OrthoDB" id="3329at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070899">
        <property type="term" value="P:mitochondrial tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.570:FF:000001">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.570">
        <property type="entry name" value="GidA associated domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049312">
        <property type="entry name" value="GIDA_C_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026904">
        <property type="entry name" value="MnmG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047001">
        <property type="entry name" value="MnmG_C_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044920">
        <property type="entry name" value="MnmG_C_subdom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="GLUCOSE INHIBITED DIVISION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PROTEIN MTO1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21680">
        <property type="entry name" value="GIDA_C_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13932">
        <property type="entry name" value="SAM_GIDA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01228">
        <property type="entry name" value="GIDA_assoc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain" evidence="5">
        <location>
            <begin position="78"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS79143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="164" mass="18587" checksum="DED4B2D9F1DB5553" modified="2019-05-08" version="1">MRAELDTNLQLLQQTRRSSHAWRRPLGLPENKDAGLMSGRDILCNADVTLDDLAATFPEFSHLRDASRQLRERLEIEVKYSHEIQAQQEAIQQVKREEQMLLPEDMDYFSLNMSNDAKSKLAEARPASIAAASRIPGMTPAAIVILLNHVKSTQRATSPRPNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TFJ9</accession>
    <name>A0A433TFJ9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_011865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000395">
        <property type="protein sequence ID" value="RUS80368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TFJ9"/>
    <dbReference type="STRING" id="188477.A0A433TFJ9"/>
    <dbReference type="OrthoDB" id="6114554at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS80368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="210" mass="24013" checksum="038888ED3568EEA8" modified="2019-05-08" version="1">MSLPSAPHIATAEIAPAGMRWPKFIGYMLWCMLEPTRHDKAALLPQSRRTCLKPDCLSAEEYKCGKARLFSMLEDSDDPVVKTVQPSIKTGRKWKAVTAVDQAKECLKIKEVIGQTQTDRKGLGSSTTKWWSKAEGKEKRDMVINEIRLNEDSRKTQKAVQQRQQGQWTNWDNVLQKSLSWNDIWHMAPLRISFLIRSVYDLLPSNANLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TGK0</accession>
    <name>A0A433TGK0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GRF-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_011514</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000376">
        <property type="protein sequence ID" value="RUS80728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TGK0"/>
    <dbReference type="STRING" id="188477.A0A433TGK0"/>
    <dbReference type="OrthoDB" id="431817at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008988">
        <property type="term" value="F:rRNA (adenine-N6-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041370">
        <property type="entry name" value="Mlase_EEF1AKMT1/ZCCHC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039846">
        <property type="entry name" value="ZCCHC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13493:SF3">
        <property type="entry name" value="RRNA N6-ADENOSINE-METHYLTRANSFERASE ZCCHC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13493">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10237">
        <property type="entry name" value="N6-adenineMlase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GRF-type" evidence="10">
        <location>
            <begin position="22"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS80728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="377" mass="43730" checksum="ED42F751D44D98B5" modified="2019-05-08" version="1" fragment="single">MAARQANIEVLAPPQNMIVPSCPHGPALLFEQYDRSSKTSRQFFACSAFRDKKECDLHVWADEGAYKSTQISQHISHKQYRMRFRKFRALPRNKRHVCCTCGLLLLPSEISDHERQDHEMKRRVLLKDLRKPSFLFSPLDNNKTFAQYLFSPMTVDFLIGSIERLACYTHVLCVGAPRMHEEIQLRRRRGDSALTSMLLDLDERYAQLYSPGSFAKYNMFNHHFFEKSGRKRLEMFLKDASQGALLLTDPPFGGMVEALVQSFVKISSMWQEIVGSPTAERDVSIPMMWIFPYFLESRIVTSLPSLSMLDYKVDYDNHNLFNNNHKQKGSPVRIYTNIPSAQFQLPEEDGYWFCEPCQRFSAKENHHCRDCGTCPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TIG6</accession>
    <name>A0A433TIG6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_010876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000341">
        <property type="protein sequence ID" value="RUS81378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TIG6"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS81378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="156" mass="17981" checksum="BBE810D9B64C8F1D" modified="2019-05-08" version="1">MNSSTVTRQPRGLQRNQRRGKRIRRGLRPQPQVLNMKKKNSSTVMGQAGGLQRNQSHVKTRQRDLRFQPQVAHEKGLNMKKRNTTTVMRQPSGMKLKQSHVKKRQLDLRLPPQVAHEKGNKIKKMNTTTVTRQPSGKQMQLDLRLQPQAVQPKAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TIH8</accession>
    <name>A0A433TIH8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_010898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000343">
        <property type="protein sequence ID" value="RUS81331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TIH8"/>
    <dbReference type="OrthoDB" id="6122308at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS81331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="292" mass="33430" checksum="A69C579BA06E51AD" modified="2019-05-08" version="1" fragment="single">MSFLFEPVSAAIQTLKHIKSASDKGPDPERFIVRLPMHPGKLALGAAFKRKHNLWKWTHFRPSKVPRKRKFKIGQKKRNVRHEIDETPEAAEAGQATADLDTPVAGAPSAPTQDDVTGSGSGSALQSSQDQDTESVQRHSKTARVSIIPDDDMPYFPIPDEEERENEVKRIAEMSPEQRVYHRSCEHYKVKPLRQIMKQIDTKEIILAHTKMKDTEFKAFSTALVMNFTVRRVDMSDTMPTEQQTTYLTDLLEDDNGITDLIFKDNHLEGRLMSRIFYSMRQKDIMIYLDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TII7</accession>
    <name>A0A433TII7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_010867</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000341">
        <property type="protein sequence ID" value="RUS81369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TII7"/>
    <dbReference type="STRING" id="188477.A0A433TII7"/>
    <dbReference type="OrthoDB" id="6242194at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027124">
        <property type="entry name" value="Swc5/CFDP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23227">
        <property type="entry name" value="BUCENTAUR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23227:SF67">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS81369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="35971" checksum="C48A2F6DC83EAFDE" modified="2019-05-08" version="1">MDRIWKVVLASGETIIYSGLAEGETHMHGVALMMSHKATGALLSWEPLSPRVLTARFNSKGRKVTVIQCYAPTNTADIEDKEDFYEQIQAAIDKTPKRDMKILMGDLNAKVGADNTDRELIMGRHGVGQQNENGELFTEFCSFNDLTIGGTLFPHKIIHKTTWTSPDGKTENQIDHITIETWRVTKTNSKKIQGFTNRCLRNILGVHWPEVISNEELWERTRQTPVETEIMKRKWGWIGHTLRKPASNITRQALDWNPQGKRKVGRPKQSWRRSVEEEVKASGTTWAELKRTCQNRVRWRSFVEALCSSRNQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TIP9</accession>
    <name>A0A433TIP9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BMP and activin membrane-bound inhibitor homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_010829</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000339">
        <property type="protein sequence ID" value="RUS81391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TIP9"/>
    <dbReference type="STRING" id="188477.A0A433TIP9"/>
    <dbReference type="OrthoDB" id="5914644at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23576">
        <property type="entry name" value="TFP_LU_ECD_BAMBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045806">
        <property type="entry name" value="BAMBI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045807">
        <property type="entry name" value="BAMBI_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06211">
        <property type="entry name" value="BAMBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19337">
        <property type="entry name" value="BAMBI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="BMP and activin membrane-bound inhibitor N-terminal" evidence="3">
        <location>
            <begin position="5"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="BMP and activin membrane-bound inhibitor C-terminal" evidence="4">
        <location>
            <begin position="148"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS81391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="477" mass="50979" checksum="64A81C25CA6AC4D6" modified="2019-05-08" version="1" fragment="single">LSTSSGELRCHCNESGCVATGYMCKSQAGQCYTALEVRGEDTHLTHGCLDSLPSHHRALCQRVADPAGPSAGATASRLAGDGDPQGGDSSAPTLLCCTEHMCNYREDTDIGVNLMPKHNSTYRRGGLAKINEGSVYARDHHSARRRDDEADRDLWFKAAVIAVPIAGGFILVLLVLLAVRMLRSDSTRHRRLIQIRRERSLTKAQMYISEHFMGGAGTSTSIGVKNKLQHSSLFSEKPQQHPHRESYSIYSEKIPASSAALTVSSARAASNHGGGSVTAPRGSSDNSNVFSSTGSSICKNSSNASSSGGHNNTGGFTSDICCTDERPCCGGLCSVQRETQTRHCEACNNKRRSLSSFNTTYCRCSKTCHSNPSDCASSPKSTSAIKTPISSSSNSEEDLSAGRQPKSSSHARHSPCSFSTDSPPIINPGGGVLSTDKYSEIPAHLNSAPSNNCDHNQYRTVVAHWDKTNPRAPTALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TIW9</accession>
    <name>A0A433TIW9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_010731</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000334">
        <property type="protein sequence ID" value="RUS81503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TIW9"/>
    <dbReference type="OrthoDB" id="10644035at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019275610" evidence="2">
        <location>
            <begin position="17"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="93"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS81503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="271" mass="31861" checksum="3E0D6B5816F36A31" modified="2019-05-08" version="1">MVPLLCLMALVPMAFAGMSMEEMMHMQQMMNWQEQQQGWNNWGNGMGNGMGNGMGNGGGGMQQGGGNMQQGGQWWNMMSAEDAEAYRKWCEERQRATAEQQQQKELLEMWEKQEEQRKMEAEKRKREHEAEERHESMMAQWKMWQQRIAQQHEFDDLMYKFHEQKHMYMYLVTMEVLKFCRCTDFTSELGRYFMHDGISWDSHDDFDLDELEKISTDDAFAVAQALAGRPKSDQVKAFFGGLAESLCGSARGYVEQVMQWEKTYNFIDRYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TK15</accession>
    <name>A0A433TK15_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_010284</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000313">
        <property type="protein sequence ID" value="RUS81939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TK15"/>
    <dbReference type="STRING" id="188477.A0A433TK15"/>
    <dbReference type="OrthoDB" id="6021021at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF248">
        <property type="entry name" value="PICKPOCKET 17, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 11" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="9 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS81939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="550" mass="60178" checksum="79B2BDD6E4360992" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TKC4</accession>
    <name>A0A433TKC4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_010235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000309">
        <property type="protein sequence ID" value="RUS82008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TKC4"/>
    <dbReference type="STRING" id="188477.A0A433TKC4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS82008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="131" mass="15016" checksum="CD91250D05F911EA" modified="2019-05-08" version="1" fragment="single">VDLKYLFNETGSKLFYIETGSNLFYIESGLKLFYSESGSKLFYIETGSKLFYTESGLKLFYTETGLKLFYIETGSKLFYSESGSKLFYIETGSKLFYTESGLKLFYSETGSKLFYSESGLKLFYTETGSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TLB7</accession>
    <name>A0A433TLB7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_009964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000293">
        <property type="protein sequence ID" value="RUS82286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TLB7"/>
    <dbReference type="STRING" id="188477.A0A433TLB7"/>
    <dbReference type="OrthoDB" id="413313at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF1">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS82286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="261" mass="30678" checksum="5E346703E7BEF970" modified="2019-05-08" version="1" fragment="single">QFSHCRYKEITRKEGIDTFFVYTWFSDNFTDSAPLPLWHDNVVSECFDTNGAVISRSYFPLIRKKPEIEERLHKKYQTHVEKNSPTETLSILMIGVDGMSKQNFERALPKTRKFLLEAMGAIELYKYNKLAFETFPNVLALLTGHTPEEFYKNWRYNRTGFVDQINDAFLWTDARNIGYRTGMMLDCYDITAFHYQKKGFKVSPVDYYQRQTVIASTRDKLMRGNNSNCVGDMPEVTQIHDYWLQMARAFGKDKSTPFFAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TM77</accession>
    <name>A0A433TM77_ELYCH</name>
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        <recommendedName>
            <fullName evidence="5">Mob1/phocein family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_009520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">EC2010</strain>
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    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="188477.A0A433TM77"/>
    <dbReference type="OrthoDB" id="8170117at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="239"/>
            <end position="380"/>
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    </feature>
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            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="542"/>
        </location>
    </feature>
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            <begin position="240"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <end position="344"/>
        </location>
    </feature>
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    </feature>
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    </feature>
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            <end position="542"/>
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    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS82683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="542" mass="57940" checksum="98EBF5B791845E40" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TNK3</accession>
    <name>A0A433TNK3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SAND domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_009109</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000257">
        <property type="protein sequence ID" value="RUS83120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6160714at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Deformed epidermal autoregulatory factor 1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAND-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR000770">
        <property type="entry name" value="SAND_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10417">
        <property type="entry name" value="GLUCOCORTICOID MODULATORY ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10417:SF15">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN-CONTAINING 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01342">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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        </location>
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</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
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            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000246">
        <property type="protein sequence ID" value="RUS83364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TP65"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019236985" evidence="1">
        <location>
            <begin position="19"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS83364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="148" mass="15999" checksum="1A4EDE78062B674F" modified="2019-05-08" version="1">MKVAVALLLTLAVSLVSAASIETRFIGNFFKDTWSNIKSATTNAWNKVSNTVSDYNIGDRLGQIKDKIQAKYGDITSDMNNVTFVDIAKAAKDVFVDSEQILGVDVVKSKVIEAIKEKSDIMFNDAINKAVEGVVEDIASSISFGGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TPF4</accession>
    <name>A0A433TPF4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_008771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000242">
        <property type="protein sequence ID" value="RUS83455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TPF4"/>
    <dbReference type="STRING" id="188477.A0A433TPF4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS83455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="163" mass="19975" checksum="F1B35A7BD8A4F760" modified="2019-05-08" version="1" fragment="single">HYTESQLTYTGHRISNHTVSQLTYTDHRIRNHTESQLTYTYHRIRNHTESQLTYTDHRIRNHTESQLTYTDHRIRNHTESQLTYTDHRIRNHTESQLTYTDHRIRNHTESQLTYTDHRIRNHTESQLTYTDHRISNHTEPKLTHTYHIMRYYTGPQLTDTDHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TPH8</accession>
    <name>A0A433TPH8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_008739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000241">
        <property type="protein sequence ID" value="RUS83489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TPH8"/>
    <dbReference type="STRING" id="188477.A0A433TPH8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS83489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="221" mass="25169" checksum="C863D8088C5EF0DC" modified="2019-05-08" version="1" fragment="single">VRLVPQTASVLTLRYVRLIPQTARVQTSRYVRLIPQTASVLTSRYVRLIPQTASVLTSRYVRLIPQTASVLTLRYVRLIPQTSSVLTLRYVRLIPQRASVQTSRYVRLIPQTASVLTLRYVRLIPQRASILTLRYVRLIPQTASVLTLRYVRLIPQTASVLTSRYVCLVPQTASVLTLRYVRLIPQTASLLTSRYVRLIPQTASVLTSRYVRLIPQTASLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TRQ3</accession>
    <name>A0A433TRQ3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_007965</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000211">
        <property type="protein sequence ID" value="RUS84272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TRQ3"/>
    <dbReference type="OrthoDB" id="6149331at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15039">
        <property type="entry name" value="7tmB3_Methuselah-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053231">
        <property type="entry name" value="GPCR_LN-TM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902:SF1">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="528"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="568"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="610"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="658"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="685"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="6">
        <location>
            <begin position="519"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS84272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="748" mass="84533" checksum="51303C761AD56165" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TS32</accession>
    <name>A0A433TS32_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_007882</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000208">
        <property type="protein sequence ID" value="RUS84350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A433TS32"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
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        <property type="entry name" value="Su(sable)-like"/>
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        <property type="entry name" value="Znf-CCCH_ZC3H4/6/8"/>
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    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
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    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13119:SF12">
        <property type="entry name" value="PROTEIN SUPPRESSOR OF SABLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13119">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22623">
        <property type="entry name" value="zf-CCCH_9"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="67"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="259"/>
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    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="288"/>
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    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="631"/>
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    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="682"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="891"/>
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    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1004"/>
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    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1352"/>
            <end position="1646"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="67"/>
            <end position="91"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="149"/>
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            <begin position="177"/>
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            <begin position="220"/>
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            <begin position="259"/>
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            <begin position="296"/>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
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    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50103"/>
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    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS84350.1"/>
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    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
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    <sequence length="1674" mass="175246" checksum="EBEFDDEC196DF6D1" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TTT1</accession>
    <name>A0A433TTT1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial</fullName>
            <ecNumber evidence="5">2.3.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">2-oxoglutarate dehydrogenase complex component E2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">E2K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">EGW08_007279</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">EC2010</strain>
            <tissue evidence="18">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.61" evidence="5"/>
    <dbReference type="EMBL" id="RQTK01000187">
        <property type="protein sequence ID" value="RUS84968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TTT1"/>
    <dbReference type="STRING" id="188477.A0A433TTT1"/>
    <dbReference type="OrthoDB" id="5391403at2759"/>
    <dbReference type="UniPathway" id="UPA00868">
        <property type="reaction ID" value="UER00840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000006">
        <property type="entry name" value="Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
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        <property type="entry name" value="2-oxoacid_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006255">
        <property type="entry name" value="SucB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01347">
        <property type="entry name" value="sucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416:SF5">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="17">
        <location>
            <begin position="84"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00005145"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
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            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RUS84968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="469" mass="50139" checksum="C10666CFF6407CDD" modified="2019-05-08" version="1">MQASLTMSMRRFSQFRWLSACKQTHKTIQNASAFTQALPTATVSNGRSSLHTSHERARLPNRISPCTLSSRAFHTSLRHGAGEVISVNAPSFADSVSEGDIRWEKAVGDSVSADELVGEIETDKTNMPVYAPSDGVIEKFLVEDGATVTAGIPLFKMKLGAGAAKPAAASAPKAADAPPPPKEEPVAAAGAPIPTVLPPVGAPPAGPMASTPTAAVKPQPAASASIAPSIVGHVAGSRSEQRVKMNRMRQRIAQRLKDAQNTAAMLTTFNEIDMSNAMEMRSKYKDAFMKKHNLKLGFMSAFVKAAAFALQDQPVVNAVIDDMEIVYRDFIDISVAVATPKGLVVPVIRNVEGMNYADIEKTIAELGEKARAGSLAIEDMDGGTFTISNGGVFGSMFGTPIINPPQSAILGMHGIFERPVAIKGKVEIRPMMYVALTYDHKLVDGREAVTFLRKIKDAVEDPRTMLLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TTZ6</accession>
    <name>A0A433TTZ6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_007203</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000185">
        <property type="protein sequence ID" value="RUS85019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TTZ6"/>
    <dbReference type="STRING" id="188477.A0A433TTZ6"/>
    <dbReference type="OrthoDB" id="2419613at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="8">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS85019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="197" mass="21659" checksum="EE839EA0AAD47660" modified="2019-05-08" version="1">MLLVILTVVNPLMALFRPDKGSPSRSTFKWTHWAVGMFAWILAIALLAIGLDLPKSQADLLAVYAVFAFAGYQLVMEVLVRSIPYCLGSILTFCFDSVCTRNKHGFDLHMTNFSSPEVASVTGSGIAPDKEAAARQNAAAKRRENTIKSTILVLHMLMSACFAVGVVYFLLRKPFEYVTSGESRDEDTLDEKFAVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TWZ4</accession>
    <name>A0A433TWZ4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Replicase polyprotein 1a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_006201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000152">
        <property type="protein sequence ID" value="RUS86047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TWZ4"/>
    <dbReference type="STRING" id="188477.A0A433TWZ4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053110">
        <property type="entry name" value="Ribosomal_L1-TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48162:SF1">
        <property type="entry name" value="RIBOSOMAL L1 DOMAIN-CONTAINING PROTEIN CG13096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48162">
        <property type="entry name" value="YALI0A06930P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS86047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="42189" checksum="F2DC1052A6ADCF8A" modified="2019-05-08" version="1">MQFDNDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDNDDPTAAATSSATGARSSGHLHSHSAPQHEEQGSEGWGHLSDGDARLSDGKAISRGGPVNQVRVSHVRAQSPQGEGTSDKSSSSNRLGSSIRVHNEGQRVKRTAGRHVLVKRFNEFVGKRAREAWRRAAQAGLPFGAVGGSLSFKSFQDVDNSLGGGSLEDLQNNKLDTVQSGGEWRDQDGLRKLSSLQQPDSDLLTGAASAAGVKGGSVWPEGDAGSVESAAWRAALIKVRESPLAITKKYAEFLGKRSLPGYFGTGDESPMDEPAAPANKRYAEFLRKRAAATARGVLEAAVARGVLGQWLERMAKQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U0A2</accession>
    <name>A0A433U0A2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_004998</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000116">
        <property type="protein sequence ID" value="RUS87246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U0A2"/>
    <dbReference type="STRING" id="188477.A0A433U0A2"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005412">
        <property type="term" value="F:D-glucose:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11819:SF195">
        <property type="entry name" value="SODIUM_GLUCOSE COTRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11819">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="601"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS87246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="622" mass="67485" checksum="E20F4B3532DB541D" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U0C6</accession>
    <name>A0A433U0C6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_005038</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000117">
        <property type="protein sequence ID" value="RUS87198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U0C6"/>
    <dbReference type="STRING" id="188477.A0A433U0C6"/>
    <dbReference type="OrthoDB" id="10072641at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026811">
        <property type="entry name" value="CIZ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15491">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15491:SF9">
        <property type="entry name" value="CIP1-INTERACTING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="7">
        <location>
            <begin position="391"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="87"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="323"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="444"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="552"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="128"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="323"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="445"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="503"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="552"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="575"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="651"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS87198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="668" mass="74225" checksum="4234A5AC8F94FF6D" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U0J9</accession>
    <name>A0A433U0J9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_004825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000112">
        <property type="protein sequence ID" value="RUS87371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U0J9"/>
    <dbReference type="OrthoDB" id="6207867at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS87371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="104" mass="11864" checksum="E72D94F012D5D8F9" modified="2019-05-08" version="1" fragment="single">ALHRIYEESPTCAGNKSVQQRFIDNEEVCISRFEIPNLDETDSANCGPFKNLRNCDRNFVRSLCGDLYGWFSDRLWLAIAKVYFPICVSDLESDQQPFPPSPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U2D7</accession>
    <name>A0A433U2D7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_004269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000095">
        <property type="protein sequence ID" value="RUS87991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U2D7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS87991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="102" mass="10551" checksum="771B81C45BDA9905" modified="2019-05-08" version="1" fragment="single">DSSAVLWVGCFIAVDSAAVLWVGCFIAVDSSAVLWVGCFITVDSSAVLWVGCFIAVDSAAVLRVGCSMAVDSPAVLWVGCFITVDSSAVLWVGCFIAVDSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U2Y5</accession>
    <name>A0A433U2Y5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_004031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000090">
        <property type="protein sequence ID" value="RUS88199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U2Y5"/>
    <dbReference type="OrthoDB" id="6154219at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS88199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="408" mass="44520" checksum="893639735C89DD5D" modified="2019-05-08" version="1">MSSLRSSSVGVMRPPKPPCWRDFVVSSARSFAATDALDTFQETAGRALGSRCAVTDLEPLGPSNSRPSALSAAPGARIGRLARRPRARIHRTRSEHVILPEDLPDSSGATPVPRTAAVPEDSRPALRPRPRALTPDDQIDVEENNKRCQNWLASIEAAEPLDEVDYNSLGELGQEQSSVKNVPLARRDIDLDLRGEAKTSNEEEDEHITELGQATVEMEIPEETFQWEEDAFPPSDSHRETRHRFPTDSDAGECRACKVSARGGGVSANTPVPSGSNSRKFTGPPLCGTCTDCISCGSGDPSSSGASENNTQYTGRAINVEDRSRVLCTCTHSPTSPKSANKRSILRKSLSSKTPGFRPGTDRSTSSPAVTRSSGRMVFMGIGRWRWWRWSWRRWPVRQIGPKAAADC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U3D3</accession>
    <name>A0A433U3D3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_003895</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000086">
        <property type="protein sequence ID" value="RUS88324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U3D3"/>
    <dbReference type="STRING" id="188477.A0A433U3D3"/>
    <dbReference type="OrthoDB" id="5141738at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17317">
        <property type="entry name" value="MFS_SLC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="517"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="18"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS88324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="602" mass="66916" checksum="77DFE3F27B747A5B" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U4I6</accession>
    <name>A0A433U4I6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_003526</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000075">
        <property type="protein sequence ID" value="RUS88711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U4I6"/>
    <dbReference type="STRING" id="188477.A0A433U4I6"/>
    <dbReference type="OrthoDB" id="7765170at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006259">
        <property type="term" value="P:DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="3">
        <location>
            <begin position="386"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="527"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS88711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="609" mass="68560" checksum="A813E26BC6F9A720" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U8X7</accession>
    <name>A0A433U8X7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Tyrosine-protein kinase receptor</fullName>
            <ecNumber evidence="22">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">EGW08_002017</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">EC2010</strain>
            <tissue evidence="28">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20 22">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="22">Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="22"/>
    <dbReference type="EMBL" id="RQTK01000037">
        <property type="protein sequence ID" value="RUS90236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A433U8X7"/>
    <dbReference type="OrthoDB" id="5809444at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005899">
        <property type="term" value="C:insulin receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005009">
        <property type="term" value="F:insulin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043560">
        <property type="term" value="F:insulin receptor substrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042593">
        <property type="term" value="P:glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="3"/>
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        <property type="entry name" value="PTKc_InsR_like"/>
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        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Receptor L-domain"/>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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        <property type="entry name" value="Furin_repeat"/>
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        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
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        <property type="entry name" value="Ig-like_fold"/>
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        <property type="entry name" value="Prot_kinase_dom"/>
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        <property type="entry name" value="Protein_kinase_ATP_BS"/>
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        <property type="entry name" value="Rcpt_L-dom"/>
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        <property type="entry name" value="Rcpt_L-dom_sf"/>
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        <property type="entry name" value="RTK"/>
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        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
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    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
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        <property type="entry name" value="Tyr_kinase_cat_dom"/>
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    <dbReference type="InterPro" id="IPR002011">
        <property type="entry name" value="Tyr_kinase_rcpt_2_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF525">
        <property type="entry name" value="INSULIN-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
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        <property type="match status" value="3"/>
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        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00239">
        <property type="entry name" value="RECEPTOR_TYR_KIN_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="19" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 22" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17 22" id="KW-0675">Receptor</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 25" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 22 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="15" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="25">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019506573" description="Tyrosine-protein kinase receptor" evidence="25">
        <location>
            <begin position="32"/>
            <end position="1758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="979"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="27">
        <location>
            <begin position="496"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="27">
        <location>
            <begin position="617"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="27">
        <location>
            <begin position="874"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="26">
        <location>
            <begin position="1042"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="790"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1367"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1480"/>
            <end position="1758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="792"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="1480"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="1521"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="1626"/>
            <end position="1637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="1654"/>
            <end position="1664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="1678"/>
            <end position="1690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="1748"/>
            <end position="1758"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="1077"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU000312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="RUS90236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1758" mass="196140" checksum="D1D5DC44718FB1FF" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UAW2</accession>
    <name>A0A433UAW2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA mismatch repair protein MLH1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">DNA mismatch repair protein Mlh1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">MutL protein homolog 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">EGW08_001309</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">EC2010</strain>
            <tissue evidence="18">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000022">
        <property type="protein sequence ID" value="RUS90912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UAW2"/>
    <dbReference type="STRING" id="188477.A0A433UAW2"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03483">
        <property type="entry name" value="MutL_Trans_MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000014">
        <property type="entry name" value="DNA mismatch repair protein Mlh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000034">
        <property type="entry name" value="DNA mismatch repair protein mlh1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032189">
        <property type="entry name" value="Mlh1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF12">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16413">
        <property type="entry name" value="Mlh1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="17">
        <location>
            <begin position="216"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="347"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="625"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="353"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="393"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00082865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RUS90912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="692" mass="77465" checksum="43FA7EC68B44D3D7" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UDB0</accession>
    <name>A0A433UDB0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_000487</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000006">
        <property type="protein sequence ID" value="RUS91779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UDB0"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS91779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="154" mass="16540" checksum="BDB4AE1A4D06EE4C" modified="2019-05-08" version="1">MLNPPTVKSLPLRTDGCWAANLTTEVTSVLLNTTTAAFSDSTTLSASGEGGSSRLYLSYQHYSTLTLLVSVVVACLVSLITGRNNKQVVDPRTYIHYSWSSLNSDTLTTYDLNDSSGSSSDEGKGKVKDLHRGTDSEEDKGKQNSPKIFVTGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z8P0</accession>
    <name>A0A3S0Z8P0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine/threonine-protein kinase 40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_022876</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001711">
        <property type="protein sequence ID" value="RUS69361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z8P0"/>
    <dbReference type="STRING" id="188477.A0A3S0Z8P0"/>
    <dbReference type="OrthoDB" id="410920at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024104">
        <property type="entry name" value="Tribbles/Ser_Thr_kinase_40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22961">
        <property type="entry name" value="SER/THR PROTEIN KINASE-TRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22961:SF16">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="642"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="323"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="597"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="956"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="75"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="131"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="341"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="397"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="421"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="474"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="493"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="521"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="618"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS69361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1059" mass="114612" checksum="255F1F22F9AE1D0C" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2024-05-29" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZEX3</accession>
    <name>A0A3S0ZEX3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_014895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000588">
        <property type="protein sequence ID" value="RUS77341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZEX3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS77341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="121" mass="13941" checksum="7DAD8EBD7F266B46" modified="2019-04-10" version="1">MGRNGSLLIQPQGTKQIVLKPPASFAIQRQSNYKSSTKHKLTKYLSCHTTLLIINRGYKSINTVLSFWDLHCMSYRIRNVQKNQTTTIYKKHLRSNIIGNKFPNFNSSSSLTIFHPTSFQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZIT7</accession>
    <name>A0A3S0ZIT7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_013482</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DONSON family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000491">
        <property type="protein sequence ID" value="RUS78766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZIT7"/>
    <dbReference type="STRING" id="188477.A0A3S0ZIT7"/>
    <dbReference type="OrthoDB" id="534063at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033260">
        <property type="term" value="P:nuclear DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024861">
        <property type="entry name" value="Donson"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12972">
        <property type="entry name" value="DOWNSTREAM NEIGHBOR OF SON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12972:SF0">
        <property type="entry name" value="PROTEIN DOWNSTREAM NEIGHBOR OF SON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02064">
        <property type="entry name" value="DONSON"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="177"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS78766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="445" mass="50479" checksum="66DCCBA4DE4D889B" modified="2019-04-10" version="1">MRVVVESREETFRRIPGIDAKNVFNFVHHTLQNGSDWKELDIFQKLRRCCLHYSYPQYPWMRKFPRMSGDFRSRSMSFLSNNEDVLSDIQSDWSSVFTALYQQLRGGICPYFYVCTHQFTVLFRCQRFSPKEASFSALLSPSTRGFREMLSKEDITFRLPNIDMHKIPSDEIKPKVEFESPSSAQVRSPSTVDNHGDNTDETGPVEDAASENEDEEDDINDHHGASEWLEQMGLERKDFPSLEPLKVKLQRDGYREIDNRPQSMVYVEGGDVHAFFNFLLNYPSCIASSGPQHGLPPTLLSPVPFVGGALVQNTVKHSQLRDVPVKLPGTEQNMYSHVFEISGPILPHHTLNIAAILEDYHAQQQGSSVVTYNTHLPSAALNTQAVNQPETDRLAVNLHKLFVDFDLANKGLLSSCKDSLGSKPKLSSGAFLREMKISQQGYLWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZJ71</accession>
    <name>A0A3S0ZJ71_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_023537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01002086">
        <property type="protein sequence ID" value="RUS68701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZJ71"/>
    <dbReference type="OrthoDB" id="6142965at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018660160" description="Fibronectin type-III domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="244"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS68701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="377" mass="42999" checksum="0526813782F835CC" modified="2019-04-10" version="1" fragment="single">MAAARKNYTLWNLIYLISICGTANSLFNQPKAVIDPPDSFVIIGETVRVTCSSSELFKGDVSQVQFKITTNNNAWFLPTENQTDLGNSVVQTYVHVTEQFSSITSLSCFHREKQVRSTKIYTEKPLMRINITKIFFEDRGSYVHFTWLSNTKYYIDPDKIQTKALYSFGGQPENWTTDGTACGEIPDFLCDANQAIGYNIYIRFYVSYSTLRKRPGLDYLQPLFDTQVSSDYNFTFEDIRKTTPVTDVQLKDVGKVCTNVTWTLPYYIAEICYKCPQLLYMIELIEGGNEKLLIEGTQRPPASGQSVQVCGLTPFTQYTLTVRVKVQEVNPWSDPSIPIQLTTAEDRPLAGPLLMDTGYHTERSCNNGKRQMLIYWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZJZ5</accession>
    <name>A0A3S0ZJZ5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribonuclease 3</fullName>
            <ecNumber evidence="6">3.1.26.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Ribonuclease III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19 20">protein Drosha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">EGW08_015693</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">EC2010</strain>
            <tissue evidence="25">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ribonuclease III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.3" evidence="6"/>
    <dbReference type="EMBL" id="RQTK01000654">
        <property type="protein sequence ID" value="RUS76538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S0ZJZ5"/>
    <dbReference type="OrthoDB" id="67027at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070877">
        <property type="term" value="C:microprocessor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031054">
        <property type="term" value="P:pre-miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031053">
        <property type="term" value="P:primary miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19877">
        <property type="entry name" value="DSRM_RNAse_III_meta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000002">
        <property type="entry name" value="Drosha ribonuclease III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000012">
        <property type="entry name" value="Drosha ribonuclease III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00104">
        <property type="entry name" value="RNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058938">
        <property type="entry name" value="Helical_CED_Drosha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011907">
        <property type="entry name" value="RNase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044442">
        <property type="entry name" value="RNAse_III_DSRM__animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF0">
        <property type="entry name" value="RIBONUCLEASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26050">
        <property type="entry name" value="Helical_CED_Drosha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0464">Manganese</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="15 21" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="24">
        <location>
            <begin position="967"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="24">
        <location>
            <begin position="1199"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="23">
        <location>
            <begin position="1354"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="116"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="548"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1445"/>
            <end position="1504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="244"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="302"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="360"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="22">
        <location>
            <begin position="557"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="573"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="589"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="1445"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="22">
        <location>
            <begin position="1474"/>
            <end position="1484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00078955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00083702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="RUS76538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1504" mass="172360" checksum="87B50177EB90C80D" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZKR8</accession>
    <name>A0A3S0ZKR8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_012202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000414">
        <property type="protein sequence ID" value="RUS80032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="6162830at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="523"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS80032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="753" mass="82253" checksum="BA9A1DC359F2173E" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZLF9</accession>
    <name>A0A3S0ZLF9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_014632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000567">
        <property type="protein sequence ID" value="RUS77611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZLF9"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS77611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="107" mass="13062" checksum="67B597A8F8C2FE63" modified="2019-04-10" version="1">MIYTLCTKLQGHINGQLDTFFMLISYLYLMPIMHIMEANPTWRILDEHFSKKKRGKYIYIYIYPYKHNSYIMHKEKNFDSFYVTVFSKSVLILLYTYVNLMSFMKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZNJ6</accession>
    <name>A0A3S0ZNJ6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_009052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MTFR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000254">
        <property type="protein sequence ID" value="RUS83195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZNJ6"/>
    <dbReference type="STRING" id="188477.A0A3S0ZNJ6"/>
    <dbReference type="OrthoDB" id="2133332at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007972">
        <property type="entry name" value="Mtfr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14215">
        <property type="entry name" value="PROTEIN OF UNKNOWN FUNCTION DUF729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14215:SF0">
        <property type="entry name" value="WH2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05308">
        <property type="entry name" value="Mito_fiss_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="350"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS83195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="408" mass="44768" checksum="49C04AB183F06345" modified="2019-04-10" version="1">MTDVIDDLEHALGRAVQCLTFILENLLHRIQLNQHRPLNRRTLVRWISAFMPAPKDPRVRLQPKLRDGPNNAPLHRWGSCGSLGSAYSAASLQNLVEEDLGDNLVRFRIDNNDDDYDYSAVAFEETHFAPIENLSNRFTSTPNFDQSESSSAMFSDQQGGKLAEMEVELAALRKQIAMLVMAQESSMVTDKTEEVEFLEESQTLSASPAAALPLPGSPALCSTLNDSGCESSESIPVGQKVAQSIPVAPETNAPVVIPAPPPPPPLPLFLETNRESVAELIKKRKASGFSQQEPKGVPDMADVLKGLGSVKLKAVERSPGGTPMCRRKLDHTPTDPASIIARALKRKFASHRGLSPESDQENDMSSFLSDSSSPFGQRMLKKTQRRLSLFNDSDDWTPVPSPMKTINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZNQ7</accession>
    <name>A0A3S0ZNQ7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_020521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001171">
        <property type="protein sequence ID" value="RUS71711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZNQ7"/>
    <dbReference type="STRING" id="188477.A0A3S0ZNQ7"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF136">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX35-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS71711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="119" mass="13180" checksum="E3A214723EFDBFB2" modified="2019-04-10" version="1">MAECPLSPSFAKMLLSSGQFGCSEEAITVCAMTQIQNVFVTPSGKKKEMAKEMRKFSVLEGDHLTLVNVFKAFLQNGQNAKWCHQHLLNYKGLNRAVEISNQLGRLLDKFKVKVVSCGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZPB9</accession>
    <name>A0A3S0ZPB9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">K-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_008495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000232">
        <property type="protein sequence ID" value="RUS83744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZPB9"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002487">
        <property type="entry name" value="TF_Kbox"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51297">
        <property type="entry name" value="K_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="K-box" evidence="2">
        <location>
            <begin position="41"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS83744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="315" mass="39319" checksum="8207A7619EB4F007" modified="2019-04-10" version="1" fragment="single">MPQQQQLTQSVWSHMPAQPQVQQPASLWDVDVNSEGLSSAYKAQLEQMKRQQREVERLREEERLREEEMLRQEELERKHEELRRQQEELEQQRELVRREKEELERQKQIDLQKREESKRLEEEARRQEDEKIQKEIQKQRREQHEAEKRRQDEDKKRQEEERKRERELKKQEEKKRKEEEKKRLQEDQRRQEEIRIKKQEEEEERLRQLQLEQELRLQVELQQQQEREEEERLQREAAEKDKVETHRRQQMELQRQHESLRKLQQAQREQLANMQLPAHSNWADQQSQQGGPSQSRSLTEIQEEEARKENDRLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZPT7</accession>
    <name>A0A3S0ZPT7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_012299</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000419">
        <property type="protein sequence ID" value="RUS79955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZPT7"/>
    <dbReference type="STRING" id="188477.A0A3S0ZPT7"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF113">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="12"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter family G" evidence="8">
        <location>
            <begin position="98"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF19055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS79955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="19090" checksum="3DDFE181529DE7BD" modified="2019-04-10" version="1">MHDYAKQLFDGQHQVQAVIELMGLKHVAESRIGGAMIRGVSGGEKRRISIGLQLLKDPEILLLDEPTSGLDSFTARNLVSTLANLAHKKGKLVLMSVHQPRSDIVNMLDKIAILTGGQLAYLGTPSQMVPYFTGIGYTCPLNENPCDIYSPTFEVGISIMSLSEMGAWYLRTISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZRB0</accession>
    <name>A0A3S0ZRB0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Amyloid-beta A4 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_007313</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the APP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000189">
        <property type="protein sequence ID" value="RUS84903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZRB0"/>
    <dbReference type="STRING" id="188477.A0A3S0ZRB0"/>
    <dbReference type="OrthoDB" id="6147836at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.770">
        <property type="entry name" value="Amyloid precursor protein, E2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.140">
        <property type="entry name" value="Amyloidogenic glycoprotein, copper-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.570.10">
        <property type="entry name" value="Amyloidogenic glycoprotein, heparin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036669">
        <property type="entry name" value="Amyloid_Cu-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008155">
        <property type="entry name" value="Amyloid_glyco"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011178">
        <property type="entry name" value="Amyloid_glyco_Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024329">
        <property type="entry name" value="Amyloid_glyco_E2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008154">
        <property type="entry name" value="Amyloid_glyco_extra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015849">
        <property type="entry name" value="Amyloid_glyco_heparin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036454">
        <property type="entry name" value="Amyloid_glyco_heparin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019744">
        <property type="entry name" value="APP_CUBD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036176">
        <property type="entry name" value="E2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23103">
        <property type="entry name" value="ALZHEIMER'S DISEASE BETA-AMYLOID RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23103:SF15">
        <property type="entry name" value="AMYLOID-BETA-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12924">
        <property type="entry name" value="APP_Cu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12925">
        <property type="entry name" value="APP_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02177">
        <property type="entry name" value="APP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00006">
        <property type="entry name" value="A4_EXTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56491">
        <property type="entry name" value="A heparin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89811">
        <property type="entry name" value="Amyloid beta a4 protein copper binding domain (domain 2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109843">
        <property type="entry name" value="CAPPD, an extracellular domain of amyloid beta A4 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00319">
        <property type="entry name" value="APP_CUBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51869">
        <property type="entry name" value="APP_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51870">
        <property type="entry name" value="APP_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018524725" description="Amyloid-beta A4 protein" evidence="10">
        <location>
            <begin position="20"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="E1" evidence="11">
        <location>
            <begin position="24"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="E2" evidence="12">
        <location>
            <begin position="235"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="GFLD subdomain" evidence="8">
        <location>
            <begin position="24"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="CuBD subdomain" evidence="8">
        <location>
            <begin position="121"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="185"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="123"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="134"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS84903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="41183" checksum="03DF91DE03EF3F01" modified="2019-04-10" version="1" fragment="single">MASFGVALAIVGLLQFAASASLEDKYEPMVAFICERPAMHRTVNSWVADRSVDCLDGLEDILAYCQKMYPEHNVSNVVEASYLVTIPDWPMMHTDRALPHRVRPFRCLSGTFQSDALLVPQHCEFDHRHDQSKCDGFSDWSKVAEDACRKKGDRLESFGMLLNCKLGHFSGVEYVCCPQGNSDESTRYHAPQENDKPDSWIKSSEEVTTATGKQDSASWESSISADADDDLNEDAVDLYEAYLRDQPFPTKYDNEHKKFLVAKAWMKKDQQRKITKLLQDWQAAREHVDEVRKTDKEAANRLSEEITERFQNLYSAYQDEHNSEREQLVALHLQRVQALLNDRKREAMDRYIEALDDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZSL0</accession>
    <name>A0A3S0ZSL0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nicotinate-nucleotide pyrophosphorylase [carboxylating]</fullName>
            <ecNumber evidence="5">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_007426</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12733"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Hexamer formed by 3 homodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NadC/ModD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="5"/>
    <dbReference type="EMBL" id="RQTK01000192">
        <property type="protein sequence ID" value="RUS84811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZSL0"/>
    <dbReference type="STRING" id="188477.A0A3S0ZSL0"/>
    <dbReference type="OrthoDB" id="10067394at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034213">
        <property type="term" value="P:quinolinate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000090">
        <property type="entry name" value="Nicotinate-nucleotide pyrophosphorylase [carboxylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="entry name" value="Quinolinate phosphoribosyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179:SF3">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase N-terminal" evidence="13">
        <location>
            <begin position="101"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase C-terminal" evidence="12">
        <location>
            <begin position="177"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS84811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="364" mass="39418" checksum="3D3E78FC3D9AF059" modified="2019-04-10" version="1" fragment="single">IRRTLVGPHCVTGTIISIPVQPFHRPLDLTTSVSEGKVRDSSRLRPKIIAMTTNSKDDAILKRIHNPSFLHVLSPASLKHMAREWLKEDVPSFDYAGFVVGEKEEQAIILQKESGVLAGQPFVDAVFKELDCSIEWHVAEGSHVEPIKTVATVSGKVRHLLLGERVALNCLTRASGIATAARRMAHIAAACGWNGEVAGTRKTTPGFRLVEKYALLVGGVSTHRHDLSSMIMLKDNHIWTAGNITQAVKDARVVGGFSTKIEVECRSYEEAIEAAAAGAEIVMLDNFSPQTASSTAKDLKDKFPNLIVEISGGITEATLATFCVDNVDVISLGKLTQGYQALDLSFKICKEGKDPTNPLVNNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZWE6</accession>
    <name>A0A3S0ZWE6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptide-methionine (R)-S-oxide reductase</fullName>
            <ecNumber evidence="6">1.8.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_015288</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(R)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="6"/>
    <dbReference type="EMBL" id="RQTK01000622">
        <property type="protein sequence ID" value="RUS76939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZWE6"/>
    <dbReference type="STRING" id="188477.A0A3S0ZWE6"/>
    <dbReference type="OrthoDB" id="44061at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.20:FF:000001">
        <property type="entry name" value="Peptide methionine sulfoxide reductase MsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.20">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00357">
        <property type="entry name" value="peptide-methionine (R)-S-oxide reductase MsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173">
        <property type="entry name" value="METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173:SF52">
        <property type="entry name" value="METHIONINE-R-SULFOXIDE REDUCTASE B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MsrB" evidence="8">
        <location>
            <begin position="50"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS76939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="175" mass="19295" checksum="16C78E0273704ADF" modified="2019-04-10" version="1">MNILHYVTQKQEISPKLKKLKASCDAAVAEGAKDDEGGGGAKSPPGLYDKDELQKRLSPAQFRITQKLGTEKPFSGKYVHQKDEGQYNCVVCGTALFTSDVKFESGSGWPAFYDVISKDRVVLKEESLGGLQRMEVKCSECRAHLGHVFDDGPKPTGFRFCVNSCSLDFKKHTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZXD0</accession>
    <name>A0A3S0ZXD0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_003218</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000068">
        <property type="protein sequence ID" value="RUS89047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZXD0"/>
    <dbReference type="STRING" id="188477.A0A3S0ZXD0"/>
    <dbReference type="OrthoDB" id="6081913at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF375">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS89047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="370" mass="41755" checksum="BD697CA7B9636E0D" modified="2019-04-10" version="1">MLFGVLSAMFTPWTLAASALTLLVYYAWTKTRLKHEGSNIPPFPAPAKPFLGHSLLLKGDILDNLAWMRKKTGDIYSLNLFGQHWIVVNGYENLKEVLVKHADKTQDRPLSLASKVLKEDNHGLITSTGRNFKEQRMITNTILRDFGMGKNIMAEKVALEVQTFIETLESYEEKPTDVHQIVSAAVCNIICSILVGHRSRRKCLRKSKRMLEPPARPPSQTCPKLRYLTAVIRETQRLAGVSPLGTRAVSQSFELQGYLIPEGSQLFINLNSALHDQSSWENPLQFRPERFLDANGDVLKPGEFLPFGLGRHNCVGEALARTELDLFLASMFQRFRFEPENPTQLPPLKGVLTINLSPQTFKVKFVGRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZYF7</accession>
    <name>A0A3S0ZYF7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mediator of RNA polymerase II transcription subunit 15</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Mediator complex subunit 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">MED15</name>
        <name evidence="5" type="ORF">EGW08_002470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000048">
        <property type="protein sequence ID" value="RUS89767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZYF7"/>
    <dbReference type="OrthoDB" id="10055322at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.20">
        <property type="entry name" value="Coactivator CBP, KIX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036529">
        <property type="entry name" value="KIX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019087">
        <property type="entry name" value="Med15_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09606">
        <property type="entry name" value="Med15_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0010">Activator</keyword>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator of RNA polymerase II transcription subunit 15 N-terminal" evidence="4">
        <location>
            <begin position="31"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="97"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS89767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="127" mass="14816" checksum="32844A1FC35C7B6D" modified="2019-04-10" version="1">MADTENEVQVVSDDPQEPVKPMEPEEETVDTEEWKMEKYRIKVVERIQDEITKTESEVTKTATELEEFAYNKAVSKRTYLDFIARILVYVAQFNEKKEEKARAEEKGNAEESETVKQEDESQETTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A147</accession>
    <name>A0A3S1A147_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CHCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_004279</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000095">
        <property type="protein sequence ID" value="RUS88001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A147"/>
    <dbReference type="STRING" id="188477.A0A3S1A147"/>
    <dbReference type="OrthoDB" id="7481291at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039289">
        <property type="entry name" value="CHCHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622:SF0">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS88001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="11327" checksum="3687203870245525" modified="2019-04-10" version="1" fragment="single">YIKCSSFSQTGKDQVIFATQEDMGEPSKAIINVDDSEEQPGDFLLVLSQGLILPNGDINWECPCLGGMATGPCGVQFREAFSCFHYSAAEPKGSDCYEAFLTMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A2K0</accession>
    <name>A0A3S1A2K0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_011190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000358">
        <property type="protein sequence ID" value="RUS81050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A2K0"/>
    <dbReference type="OrthoDB" id="8964540at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS81050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="109" mass="12591" checksum="27C10038CFCC7D81" modified="2019-04-10" version="1" fragment="single">RCVRESTSKTRNIAKTRNIVKTRNIAKTRNIAKTRNIAKTRIIAKTRNIAKTRNIAKTRNIAKTRNVVNMRNIAKTRNIAKTRNIVKTRNIAKTRNIAKTRNIVKTRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A3K4</accession>
    <name>A0A3S1A3K4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase S54 rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_010390</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000317">
        <property type="protein sequence ID" value="RUS81867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A3K4"/>
    <dbReference type="STRING" id="188477.A0A3S1A3K4"/>
    <dbReference type="OrthoDB" id="2146116at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042058">
        <property type="term" value="P:regulation of epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050708">
        <property type="term" value="P:regulation of protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051512">
        <property type="entry name" value="Inactive_Rhomboid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45965">
        <property type="entry name" value="INACTIVE RHOMBOID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45965:SF3">
        <property type="entry name" value="INACTIVE RHOMBOID PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="8">
        <location>
            <begin position="324"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS81867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="530" mass="58948" checksum="E3EA6A11B0E55C6F" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AQN8</accession>
    <name>A0A3S1AQN8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Glycosyl transferase 64 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_022909</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001726">
        <property type="protein sequence ID" value="RUS69328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AQN8"/>
    <dbReference type="STRING" id="188477.A0A3S1AQN8"/>
    <dbReference type="OrthoDB" id="5954868at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015012">
        <property type="term" value="P:heparan sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004263">
        <property type="entry name" value="Exostosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040911">
        <property type="entry name" value="Exostosin_GT47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015338">
        <property type="entry name" value="GT64_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261">
        <property type="entry name" value="ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261:SF4">
        <property type="entry name" value="EXOSTOSIN LIKE GLYCOSYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03016">
        <property type="entry name" value="Exostosin_GT47"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09258">
        <property type="entry name" value="Glyco_transf_64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Exostosin GT47" evidence="12">
        <location>
            <begin position="247"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Exostosin GT47" evidence="12">
        <location>
            <begin position="519"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase 64" evidence="13">
        <location>
            <begin position="778"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="112"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS69328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="957" mass="107325" checksum="C72AE55B4308BDD4" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1ASY0</accession>
    <name>A0A3S1ASY0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_021002</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001249">
        <property type="protein sequence ID" value="RUS71237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1ASY0"/>
    <dbReference type="OrthoDB" id="58529at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07828">
        <property type="entry name" value="lipocalin_heme-bd-THAP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014878">
        <property type="entry name" value="THAP4-like_heme-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052579">
        <property type="entry name" value="Zinc_finger_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048325">
        <property type="entry name" value="ZSWIM3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08768">
        <property type="entry name" value="THAP4_heme-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21599">
        <property type="entry name" value="ZSWIM3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZSWIM3 N-terminal" evidence="3">
        <location>
            <begin position="3"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="THAP4-like heme-binding" evidence="2">
        <location>
            <begin position="724"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS71237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="806" mass="89533" checksum="4F5A8C3D6D005919" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AYE3</accession>
    <name>A0A3S1AYE3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_021813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001412">
        <property type="protein sequence ID" value="RUS70423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AYE3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018790759" evidence="1">
        <location>
            <begin position="20"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS70423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="118" mass="13213" checksum="202874BF04C5C2A9" modified="2019-04-10" version="1" fragment="single">MHCLASFLFYYTLFYQIGAEENCGDASTTILEVTKTAKNVSVLCQGRKIQSSTSTAKPVLELYAVWRSGDRDDFRIKDAELFHSGTRLGRKEDEYTKNGTAKQHSFVTNGQIAVIHDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B245</accession>
    <name>A0A3S1B245_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
            <ecNumber evidence="5">3.1.3.48</ecNumber>
            <ecNumber evidence="4">3.1.3.67</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Inositol polyphosphate 3-phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">EGW08_014216</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">EC2010</strain>
            <tissue evidence="25">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:43560"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83420"/>
            <dbReference type="ChEBI" id="CHEBI:83423"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:43561"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:43552"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83416"/>
            <dbReference type="ChEBI" id="CHEBI:83419"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:43553"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,4,5,6-tetrakisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57627"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:77144"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77155"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57895"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:77156"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:20630"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:47005"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:10685"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:25017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="EC" id="3.1.3.67"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:25018"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Neuron projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTEN phosphatase protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EC" id="3.1.3.48" evidence="5"/>
    <dbReference type="EC" id="3.1.3.67" evidence="4"/>
    <dbReference type="EMBL" id="RQTK01000537">
        <property type="protein sequence ID" value="RUS78041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B245"/>
    <dbReference type="STRING" id="188477.A0A3S1B245"/>
    <dbReference type="OrthoDB" id="16692at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016314">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048870">
        <property type="term" value="P:cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051896">
        <property type="term" value="P:regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14509">
        <property type="entry name" value="PTP_PTEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000029">
        <property type="entry name" value="Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051281">
        <property type="entry name" value="Dual-spec_lipid-protein_phosph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045101">
        <property type="entry name" value="PTP_PTEN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014020">
        <property type="entry name" value="Tensin_C2-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029023">
        <property type="entry name" value="Tensin_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305">
        <property type="entry name" value="PHOSPHATASE WITH HOMOLOGY TO TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305:SF81">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10409">
        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22785">
        <property type="entry name" value="Tc-R-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01326">
        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01301">
        <property type="entry name" value="PTPlike_phytase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51182">
        <property type="entry name" value="C2_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51181">
        <property type="entry name" value="PPASE_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatase tensin-type" evidence="23">
        <location>
            <begin position="15"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="22">
        <location>
            <begin position="103"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="C2 tensin-type" evidence="24">
        <location>
            <begin position="191"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="25">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00043734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00043760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00043762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00051341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="RUS78041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="345" mass="39921" checksum="EE6E23DB7AE1A26A" modified="2019-04-10" version="1" fragment="single">MANKLIKGLVSRNKRRLKEDGFDLDLTYITPNIIAMGFPAEKLEGVYRNHMEDVIKFLETKHKDHYKVYNLCSERSYDPVKFHNRVAYYPFDDHNPPRLELIKPFCEDLDQWLASHEDNVAAIHCKAGKGRTGVMICSYMLHRQRFKDAESALKHYGAARTQDEKGVTIPSQRRYVLYYAELLQPGVVYRQVSLLLRGIRFETIPMFSGGTCTPYFEVHQLKVKVYTSPAYDGVGKDRNSLFMPVNQSNQSVPLCGDIKMEFFNKSKINKKEKMFHFWFNTFFVREAEKNHQNGVSTSFSSGGFEHNEILSLTFTKSELDRANKDKAHRLFSPNFKVSGVCLIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B2A0</accession>
    <name>A0A3S1B2A0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_018968</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000956">
        <property type="protein sequence ID" value="RUS73273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B2A0"/>
    <dbReference type="OrthoDB" id="6286464at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF306">
        <property type="entry name" value="RE01051P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="191"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="416"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="484"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="508"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="578"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="100"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS73273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="708" mass="75917" checksum="E05803003C3E46E9" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B2F4</accession>
    <name>A0A3S1B2F4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_021980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001449">
        <property type="protein sequence ID" value="RUS70258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B2F4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS70258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="191" mass="21265" checksum="0A1CDF8B2442A8CE" modified="2019-04-10" version="1">MIGLIAAFSSAEALCPLLRINGLTYDETRIWHVATQFSVHKGISLFIVLLARKEFRRQMLFVFESKQNIKRTRTANLLITQNTARQQSSRQLRFSGQAAEHQQSGSGRETPTTGPRGKTSPHPLTAMPLVVPDSQTIVCPKQGGMLSRDKQNDYETPEWLLKKEAPAPVWSLSRLLGRQKPSPVASVANSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B3R7</accession>
    <name>A0A3S1B3R7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Myosin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_020980</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001245">
        <property type="protein sequence ID" value="RUS71257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B3R7"/>
    <dbReference type="STRING" id="188477.A0A3S1B3R7"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005902">
        <property type="term" value="C:microvillus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030048">
        <property type="term" value="P:actin filament-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000004">
        <property type="entry name" value="Unconventional myosin ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010926">
        <property type="entry name" value="Myosin_TH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF802">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-IB ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06017">
        <property type="entry name" value="Myosin_TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51757">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 7" id="KW-0518">Myosin</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="8">
        <location>
            <begin position="1"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="TH1" evidence="9">
        <location>
            <begin position="836"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="7">
        <location>
            <begin position="486"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS71257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1024" mass="118170" checksum="439AC7F595A42A96" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B3V6</accession>
    <name>A0A3S1B3V6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Costars domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_013024</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000463">
        <property type="protein sequence ID" value="RUS79239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B3V6"/>
    <dbReference type="OrthoDB" id="9871914at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030017">
        <property type="term" value="C:sarcomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035025">
        <property type="term" value="P:positive regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1540">
        <property type="entry name" value="Costar domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026111">
        <property type="entry name" value="Abra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027817">
        <property type="entry name" value="Costars_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038095">
        <property type="entry name" value="Costars_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22739:SF7">
        <property type="entry name" value="EG:152A3.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22739">
        <property type="entry name" value="STRIATED MUSCLE ACTIVATOR OF RHO-DEPENDENT SIGNALING-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14705">
        <property type="entry name" value="Costars"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01283">
        <property type="entry name" value="Costars"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Costars" evidence="2">
        <location>
            <begin position="72"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS79239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="154" mass="17746" checksum="E35AC931FD5720AB" modified="2019-04-10" version="1">MTSKLSARERGQVETRSLVDRWQSFAENHRAGQSINPWNEWGHRKALDRTDPEYGRPVKGSLTEQRGKKAEQHVNNEIRELCHWINEIGTTHEDGTASVTFGKLFDAYTRISDTLVGWLVRARKRGYVTFEGEMLYQGKDNDVIITRVKMPEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B533</accession>
    <name>A0A3S1B533_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_017047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000764">
        <property type="protein sequence ID" value="RUS75188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B533"/>
    <dbReference type="OrthoDB" id="6196471at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="33"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS75188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="147" mass="16309" checksum="A0666DD122632032" modified="2019-04-10" version="1" fragment="single">MHFKLFFTGPTCTFITIAILTNKGEGITIADSFALVGTTRNFTEAERECRGRGYDGLGVVSSPEEYNHVILASQQLRTQWGLWVGLRYDLGLQKLQWDDGTDPSPNMPWVKGSAAPSEAVACARLFVAGAMGMLECHRQRFYICGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B8N4</accession>
    <name>A0A3S1B8N4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_014524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000558">
        <property type="protein sequence ID" value="RUS77712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B8N4"/>
    <dbReference type="OrthoDB" id="6159110at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS77712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="371" mass="41440" checksum="522DE23AA2F5F368" modified="2019-04-10" version="1">MTFDLLGARRKKRQTKLDRPASADVSQAMLSSGDAAASDGDTLSNGDTPVKSGKSRTRLWDSFLSKTRKIRIRKSKAPAAESSKLQARASSQPNIPISADESFRSRPMSASSPDETNKTFPSGPSKDRWRDYGIVDDEDDIDNKAYRRRREDDGNDEDDEDDESNALNRPGSSSNLRRAVYRRAPEMNENSRTRSSSSNDDIYDSTHERSVTDQTPVTRKRVGRRFFHRQTPDDGYRSSQDHSNNNSGNVDKVSRLPPSGNRRARANDLNNDLSSTPKKGNPAHEPRSLSREDLDRADSPAGSEDVVRENHRASEAVPEDDRRESMGVEEAEPEEDGVPVVEQSDLQNLGDRQCHLFQSRAATWPPSLVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BB04</accession>
    <name>A0A3S1BB04_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_012977</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000462">
        <property type="protein sequence ID" value="RUS79247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BB04"/>
    <dbReference type="STRING" id="188477.A0A3S1BB04"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS79247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="247" mass="27155" checksum="E964E33DF141B817" modified="2019-04-10" version="1">MATLISSPVTCDYIDIPSDLAKPIPTPVTCDYIDIPSDLDNHIPTPVTCDYIDIPSDLDNHIPTAVTCDYIDIPSDLDNHIPTPVTCDYIDIPSDLANHIPTPVTCDYIDIPSDLANHIPTAVTCDYIDIPSDLDNHIPTPVTCDYIDIPSDLDNHIPTPVTCDYIDIPSDLDNHIPTPVTCDYIDIPSDLDNHIPTPVTCDYIDIPSDLDNHIPTPVTCDYIDIPSDLDNHIPTPVTCDYIDIPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BCB3</accession>
    <name>A0A3S1BCB3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_014942</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000591">
        <property type="protein sequence ID" value="RUS77315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BCB3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018744962" evidence="2">
        <location>
            <begin position="20"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS77315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="141" mass="15680" checksum="F7F059F847EA8798" modified="2019-04-10" version="1" fragment="single">MRLYPLLLVLLELLAPAFSYFVLGSLSSGDNVADTGDRPQLYLDAERSYGEWGRVDKTRFGQKHKAPSSKFVNIFPSLSRHANVGRYGTERESENENGGMERNISPASQPRSDKSALIDDVISSLTKRAMPPTNELCKMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BCB7</accession>
    <name>A0A3S1BCB7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_007352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000190">
        <property type="protein sequence ID" value="RUS84883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BCB7"/>
    <dbReference type="OrthoDB" id="10573125at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS84883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="133" mass="15072" checksum="95344EA5FC5601DF" modified="2019-04-10" version="1" fragment="single">VNASRVKPGSTVKSYKVNPDTNAKLHEKNPLTDAEQPKIIQSNSSSKIHAETRDNQQEALKGKRKNKHFSTHRDDPIKAMEHWRHEIGFEAAQTIDAQCGHLYQQLGYRPVTTHRDLVNTAEISMVVDPHPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BE05</accession>
    <name>A0A3S1BE05_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PWWP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_010404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000319">
        <property type="protein sequence ID" value="RUS81812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BE05"/>
    <dbReference type="OrthoDB" id="6207887at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS81812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="26662" checksum="D6C8945332BC95D3" modified="2019-04-10" version="1">MAVDNLPWAHCMALESEADECSNFSHIPVEELRQAHNSDTIIGVWMSALRLKCRPKIVNTPDMVKHGVMRRSFDKLFFVRGVMRRRTASAKQRRELWSKAVRMGKALRAQHRAEDRKVLMESLAKAFPPIKKSGHRGSKNQPRKSAATHSPPPIPAVHQGDLIAVACEDRRYPALVLDATKADMIKVDFKWPNGHDIHEVSKRSIVWGALYFEPRAGGRAWLVTNAKEVQAKFQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BEI5</accession>
    <name>A0A3S1BEI5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chitin-binding type-4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_013288</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000480">
        <property type="protein sequence ID" value="RUS78947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BEI5"/>
    <dbReference type="STRING" id="188477.A0A3S1BEI5"/>
    <dbReference type="OrthoDB" id="64893at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018632539" description="Chitin-binding type-4 domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-4" evidence="2">
        <location>
            <begin position="25"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS78947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="222" mass="24470" checksum="9D318101C327CEE1" modified="2019-04-10" version="1" fragment="single">MSPFSPIAVLTCIMAAGLPGGVRGHGRMLDPPSRMSAYLAGFDTPPNYEDHQMNCGGISLQWDTNGGRCGVCGDPWSGPRLYERPDGAMVQGEPVITKTYSENESIKVSIQITMNHKVRFQIQFVVSRLNRQYSDQDCLDKHLLADDTGRTRFDSPSDSTGLFDFYLVLPSGVTCPQCMLQWKWRAGNNWGCDANGDCGVGKGERQEEFYACSDVKIDPRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BIE5</accession>
    <name>A0A3S1BIE5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_010749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000335">
        <property type="protein sequence ID" value="RUS81493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BIE5"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS81493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="113" mass="13872" checksum="2D5DDB659EF1D452" modified="2019-04-10" version="1" fragment="single">MYIFTNEIGLYSIMYFRNEIGLYSTMYCINEIGLYCIMYFRNEKGLYRILYFINEIGLNSTTYFKNEIGLYSTMYFRNEIGLYSIMYFRNEIGLYSIMYFRNEIGLYSIMYFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BJC4</accession>
    <name>A0A3S1BJC4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_023634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01002234">
        <property type="protein sequence ID" value="RUS68605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BJC4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS68605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="202" mass="23450" checksum="F9CFC6C31BAC8BF5" modified="2019-04-10" version="1">MIDLRNMEEERRRTLAELRDAFRLAEDRKDETKVVFQSTFITVTTKSSDFCIGFTPVLQSGSGFEKYESFMLKYNPHMNLVQCPHMTLPNIPVDLQSAVEKMSCPCVAKYGRRGVFLVIHDLLYRHVRRAFEAWGKQVDMYNDNAKNISDIVFREDDVVADSPSAGEPSTVYTMHQMKIWLDDFKQCVGKKLQRRALRIREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BNE9</accession>
    <name>A0A3S1BNE9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_004503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000102">
        <property type="protein sequence ID" value="RUS87757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BNE9"/>
    <dbReference type="OrthoDB" id="9945857at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22980">
        <property type="entry name" value="DD_VEST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040687">
        <property type="entry name" value="DUF5586"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32000:SF3">
        <property type="entry name" value="RIKEN CDNA A830018L16 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32000">
        <property type="entry name" value="SIMILAR TO HYPOTHETICAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17824">
        <property type="entry name" value="DUF5586"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS87757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="492" mass="54705" checksum="F87B303399639B6C" modified="2019-04-10" version="1">MSSQAKINAYMERHRIGPLFEDLMNKTLRDMPEEPLVYLLRTIYKKAGIEIPQTIRYGGLRKSTHELTKSVSPERPSRSADVTGSRDYEKPWATSPTRRTKPKKSEEGSKSKPDWNSDNKTKHLSSFDELWEGGGAGAGPAKKDRAVSSSAGVRKSKAGLSSSINAWASVGLEDNDEQYTSPPHRQQKFVSTRMTEEELLASEVLVSSRKSQDQKQLRSGPEDSGTASCSARERKGEIKKHRQHLGEILTQTRETSNDSGVGSDLSSAMDDDDDNDAIELLENADDLRREGVVNIPRTGYKLSRNLRHRENEPRVKLNINVNPEQFDSWQGMAREVDSLETPRSSPEQVDFEEEDEFESVSQVTGPRQPVWKVPGSDGDNKPGTSIPLRPPVADETPSQHHRRTTNKSAHPAPSRERSVEDAEELSASAKPWSEGANQVSFDESPDEPLSSRSLNSAATSGGWNIPDDTELGSAYDWNQRVRSGAPRDPRAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BQ51</accession>
    <name>A0A3S1BQ51_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_020144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001114">
        <property type="protein sequence ID" value="RUS72099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10599939at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="630"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="731"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="796"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="835"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1089"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1186"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1236"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1289"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="440"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="700"/>
            <end position="716"/>
        </location>
    </feature>
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        <location>
            <begin position="738"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="757"/>
            <end position="771"/>
        </location>
    </feature>
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            <begin position="803"/>
            <end position="814"/>
        </location>
    </feature>
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        <location>
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            <end position="857"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="858"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="996"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1097"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1123"/>
            <end position="1132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS72099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1399" mass="156744" checksum="C656D38A7C424814" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
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    <name>A0A3S1BT72_ELYCH</name>
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        </recommendedName>
        <alternativeName>
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        </alternativeName>
    </protein>
    <gene>
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    </gene>
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        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Lophotrochozoa</taxon>
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            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000847">
        <property type="protein sequence ID" value="RUS74285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23040:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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            <end position="666"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
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    <feature type="compositionally biased region" description="Basic residues" evidence="9">
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    <feature type="compositionally biased region" description="Basic residues" evidence="9">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS74285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1305" mass="144983" checksum="9BA55F1173529894" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BT75</accession>
    <name>A0A3S1BT75_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_001285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000021">
        <property type="protein sequence ID" value="RUS90981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BT75"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS90981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="212" mass="23888" checksum="8287ADC73EE62ADB" modified="2019-04-10" version="1" fragment="single">METSSNRHSSIISIGSQERFLVDLDPAQEQMKKVKKKIGKKRKPLGSPFENAIPPYETMEWTDRNSWSEGSSLLGEKLEQQLTYMELVNRATQCDWRWARAAAIWGNARLLRPTIATKPPRRPTQIVKDAVTETEHEEGALNKASQTHIEPRDEDKHKDRQDSKAKLDGTERAKESAVPIVSLTNVSDEGGEPPMIAIIDDEGTVQEVSHPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BUK1</accession>
    <name>A0A3S1BUK1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
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        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
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            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000066">
        <property type="protein sequence ID" value="RUS89090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S1BUK1"/>
    <dbReference type="OrthoDB" id="6512918at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000298">
        <property type="entry name" value="ATP-binding cassette sub-family A member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056264">
        <property type="entry name" value="R2_ABCA1-4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF250">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23321">
        <property type="entry name" value="R1_ABCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="371"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="833"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="899"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1085"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1125"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1162"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1193"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1306"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="524"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1346"/>
            <end position="1591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS89090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1724" mass="194166" checksum="5F34794C714ACD61" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BVQ0</accession>
    <name>A0A3S1BVQ0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Retinoblastoma-associated protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_016214</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the retinoblastoma protein (RB) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000693">
        <property type="protein sequence ID" value="RUS76009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BVQ0"/>
    <dbReference type="STRING" id="188477.A0A3S1BVQ0"/>
    <dbReference type="OrthoDB" id="844594at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000134">
        <property type="term" value="P:negative regulation of G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.140:FF:000001">
        <property type="entry name" value="Retinoblastoma-like 2, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000082">
        <property type="entry name" value="retinoblastoma-like protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028309">
        <property type="entry name" value="RB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024599">
        <property type="entry name" value="RB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13742:SF17">
        <property type="entry name" value="RE32990P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13742">
        <property type="entry name" value="RETINOBLASTOMA-ASSOCIATED PROTEIN RB -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11934">
        <property type="entry name" value="DUF3452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01367">
        <property type="entry name" value="DUF3452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Retinoblastoma-associated protein N-terminal" evidence="10">
        <location>
            <begin position="64"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS76009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="412" mass="46973" checksum="7E7102308E267BAB" modified="2019-04-10" version="1">MGLSEEGVDLVQQKFEEICLDLNMDTTAKQEAWINYNKMLAHYTLEGDQIHWLACALYEACRRMYTPTVGSGTMEGNCVSLTRLLRSSKLSLIQFFSKMRKWSDMASLPKSFRDKIDKLERNFAVSTVIFKKFEPIFLDIFVDPAQSHEMPRQARGRKQRRSPCTTQEVFNFAWTLFIQVKGNFPAISDDLVNSYHLLLCCIDWIFANALLGGRKDLLKKDFEGLPEDFLSVNFRPGDEAPCIMQLLCETHDGLVVEAKTIKEHWWKPFIKKLFEKKTLKGKMDNLSAVLEMGNFEENVKMINNLYEEYVLGVGDFDERIFLGDDAQEEIGTPGGQNTSDLSEQMAKRSLKQHFDETKTLTPSTPLTGRRYLKEKEASVTPVTTATQSVSRLQNMLSGCKTCPSAALLALFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BWG4</accession>
    <name>A0A3S1BWG4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_015612</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000648">
        <property type="protein sequence ID" value="RUS76636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BWG4"/>
    <dbReference type="OrthoDB" id="6150115at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS76636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="411" mass="43052" checksum="C2AD4E31FB902D8F" modified="2019-04-10" version="1">MDTIWKTCSSLYRKMNSTKDLCRIFLIFWATSLPLGDAACTFPSQLSGSWVRSRDSKSLTFTSSSVSGLAVLYSGVDLGDFSCDTLSSGRYIIASGQFSTDFGQNKYYMCWQFVAVTDNSFLLYELTSDLTATNYQVRPGVTQAASAAVDASSICSKSTSTTLFTTLVKTGASESDVAATCPTSIQANFRYNSCSSASLQACTNTKYVAADYSICNEQVFGSAGGLVSCMGSAIYQGERYVNLFLHDSGNNVVCWKVPDTNTAGDMSSTYYSGDCTTTGGASTALTLVYSAACSTDSSSDNNAGGGSEAGDGGGGGSNVGVIVGAAMGGVALIALVAVLVYCLKNRGNKVQIVYSGEEPKTNGVKSHDENVDTTEETKVEMKIPEKTPSAPSGLPPIESSNKLPPGEALRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1C1X5</accession>
    <name>A0A3S1C1X5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4502 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_011576</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000379">
        <property type="protein sequence ID" value="RUS80672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1C1X5"/>
    <dbReference type="OrthoDB" id="1914453at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070202">
        <property type="term" value="P:regulation of establishment of protein localization to chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053054">
        <property type="entry name" value="DNA_repair-scaffolding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028026">
        <property type="entry name" value="DUF4502"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34347:SF1">
        <property type="entry name" value="DNA REPAIR-SCAFFOLDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34347">
        <property type="entry name" value="DNA REPAIR-SCAFFOLDING PROTEIN SPIDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14950">
        <property type="entry name" value="DUF4502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4502" evidence="2">
        <location>
            <begin position="28"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS80672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="152" mass="17051" checksum="CD87D3EFB179407F" modified="2019-04-10" version="1" fragment="single">QSRDEISPPSSPAAGNLELEENRSSPPSFKDSQISIESEISSQSSLQQKDKMKASDWASMLQRQTTPVKGKGIQELDHEDSAKKKKKFASGSLADRLYQIQRRLKSSARMWYHSAKTEAISGKPEKEARSITVQVQSVDKMFSLYLCNCKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1GY20</accession>
    <name>A0A3S1GY20_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_023779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01002753">
        <property type="protein sequence ID" value="RUS68459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1GY20"/>
    <dbReference type="STRING" id="188477.A0A3S1GY20"/>
    <dbReference type="OrthoDB" id="6045195at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS68459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="203" mass="22051" checksum="BBE548D4148D111E" modified="2019-04-10" version="1" fragment="single">VSVMQSFQHPHIVPCVLAARCPLYLAVAMPVYPLGSLDSQLSGLCPALARLYLLQTGHALAQLHAARIAHGDVKLDNVFLMHAHHAVLGDFGLAVRLPELSMGLVPASQCGGTPSYMAPEARDAAAGSLVDPVKLDVYALGVMLWCMLVKVKASWTYDYLEETNTDPDIPDIFRPILRGVLEPVPAKRASLYELLDTLTRLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1H6I3</accession>
    <name>A0A3S1H6I3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_019022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000964">
        <property type="protein sequence ID" value="RUS73221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1H6I3"/>
    <dbReference type="STRING" id="188477.A0A3S1H6I3"/>
    <dbReference type="OrthoDB" id="10250153at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018548960" description="SCP domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="29"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS73221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="191" mass="20714" checksum="836B4AC1CA1E5663" modified="2019-04-10" version="1">MNVFAETSLTLLATLTPVTRAAITALTESDRQFLLQKHNTYRANENAVTMPDLTWSASLASEAQAWADNCNFAHQTGQSWGENIAARTSGLSTNQNAMSLMVDQWTSESQYNTDGSFSCCSSSDYSCCHLTQVVWAATTEVGCGLAMCSTLTTSSGSMSDAAYLVCYYNPRGNSPTPTCTWDWSPYQVASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HHG0</accession>
    <name>A0A3S1HHG0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_012810</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000451">
        <property type="protein sequence ID" value="RUS79433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HHG0"/>
    <dbReference type="STRING" id="188477.A0A3S1HHG0"/>
    <dbReference type="OrthoDB" id="762982at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008494">
        <property type="term" value="F:translation activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070935">
        <property type="term" value="P:3'-UTR-mediated mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12412">
        <property type="entry name" value="RRM_DAZL_BOULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000167">
        <property type="entry name" value="protein boule-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034988">
        <property type="entry name" value="DAZ_BOULE_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11176">
        <property type="entry name" value="BOULE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11176:SF57">
        <property type="entry name" value="PROTEIN BOULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0744">Spermatogenesis</keyword>
    <keyword evidence="5" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="45"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS79433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="364" mass="39400" checksum="E4E8D50E3F51CCCE" modified="2019-04-10" version="1">MNNTNTQMYETCSKMSSADVSPVTTPSSTPLTGGHPPKFGTVIPSRIFVGGIAANTTDAELKQYFSAFGAVKDTKIITDRAGVSKGYGFVTFENQDDADRIIKKESDNLIFKDRKLNIGPAVRKQGLPRPYDATIPPGSVLFTNGVPYTYQNGMAIFQTPDGSYPMAQPQQQSYATTAVMIPQNQLYMTPQYPYQQSSLQPVPANPGYIWATMPSAADVVYQTPQAYQGAELADATFVDGTTVEGNVIPVEQSLANRIHSPVTEVNCTADQTSVATVPVIPVQATAKNAVASYKKHYALTRRSFNSPTILVKHGHKVQRLMVSGTSPPTMYNGQILNPCNPTDTGDGSDAYIRYTHLPGHSTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HI31</accession>
    <name>A0A3S1HI31_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_012423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000426">
        <property type="protein sequence ID" value="RUS79824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HI31"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS79824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="151" mass="17588" checksum="57AEAE039FE2D34F" modified="2019-04-10" version="1" fragment="single">QRKEPNQKTTARNTFSSICSCQLLNKCIVERHKQNKKHHHFFSHLFFFHCTYTMLDLAPDDISIHVYTRSHQHLHEIIQHIKYYTYVQNAGGTNHHTSYPQTTCLITLTLQSKNIMGMGTVYNNTYKCALINNYNNVLGPQLEIPGCSFRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HKY8</accession>
    <name>A0A3S1HKY8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_010626</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000327">
        <property type="protein sequence ID" value="RUS81613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HKY8"/>
    <dbReference type="STRING" id="188477.A0A3S1HKY8"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034653">
        <property type="term" value="P:retinoic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF252">
        <property type="entry name" value="CYTOCHROME P450 26B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS81613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="46909" checksum="A7BBA01D33A7CA09" modified="2019-04-10" version="1">MDLPGKVGWPIVGDKSVEFYRDPLQFLNKYVDQVKSPIFKTRFLNKPTVFVCSNQGVQDVLKSTGESLDFGYEAFMKGMFGHNILFSKNGEADLFRQFLGKLFTTHCLEEYETVIKCIIAKHVDSLESTRDSFCLYKFFKVLFTDVCLTLFLGLDSTENSEQATSVMSLTTDHWRGIVAVPLDLRLVHPSSTYSKALQAKSNLLEMINTHKKRAKSGFPLKMKETCTVDGSIVNNHLLLFTSALLPKVLASICTSFCAEVGKAETSHYQERARCEDTWLDYLLKETMRLSPPLLGGRRLATKSCVIAGYTIPQDYTLVYMTHPAQRDSSVFEDPHLFKPERWAERPDLKDKLYIYGFGARGCIGEKLSSMILKSTLRSLLTKFAVQVCADQDFSHKYLPVLRPKNNLLVHLEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HMP0</accession>
    <name>A0A3S1HMP0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_009729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000283">
        <property type="protein sequence ID" value="RUS82515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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</entry>
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</entry>
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</entry>
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        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <feature type="domain" description="SH3" evidence="7">
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    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="141"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="255"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="6">
        <location>
            <begin position="379"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="287"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="226"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="287"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="319"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS91077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="481" mass="51862" checksum="54CFE72EDA7FFAEB" modified="2019-04-10" version="1">MAEGQQPEPTQLVAKYEYRAENSQELTMRKGERLLLVDDSKDWWKVRSPETGKEGFVPSNFIKVAKPKASLFSTILKKGGKKKTEGTGGIGGGRQQVTGSNYPNNSMVHNNGDARTNGNNAFNMGRGRMGGLPGTETFQLGQCVPACAKFFYTAQRADEISLSKGERIMVIERSSDGWWRGRKDDGSVGWFPSNYVEEVTAATGANSNSEGGGNLIYYTAAEAKSQSSPSHHSSHHSSSSAGGGSAENYLSAGGPAVSVVVALYTFSGKNPGELPSCEKGERLEVLNSTADSDSSPEWLSVRNSRGESGIVPTNYVTPASSAALSSGEEGSDRGTSSSSSNPQSQSHSISSVSNNSLSLSLLAGRRQFGVSGPLADHDWYYGKISRLQCEDILTKFALDGDFLIRDSESTAGHYTVSLKAPGRNKHFRVKNSAGILEIGQQKFSCLEDLIEHYKKHPIFKQESEKLYLVKPFVCPQSPPDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SJ79</accession>
    <name>A0A433SJ79_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein eS28</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S28</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_023129</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001831">
        <property type="protein sequence ID" value="RUS69109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SJ79"/>
    <dbReference type="STRING" id="188477.A0A433SJ79"/>
    <dbReference type="OrthoDB" id="10258930at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04457">
        <property type="entry name" value="S1_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000025">
        <property type="entry name" value="40S ribosomal protein S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000289">
        <property type="entry name" value="Ribosomal_eS28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028626">
        <property type="entry name" value="Ribosomal_eS28_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01200">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00961">
        <property type="entry name" value="RIBOSOMAL_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS69109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="70" mass="8114" checksum="B728E962FE9B0847" modified="2019-05-08" version="1">MLRFNARDFQKVNQVLKVLGRTGSQGQCTQVRVEFLDDSNRSIIRNVKGPVREGDILTLLESEREARRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SPW1</accession>
    <name>A0A433SPW1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alkylglycerol monooxygenase</fullName>
            <ecNumber evidence="11">1.14.16.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EGW08_020974</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">EC2010</strain>
            <tissue evidence="17">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>1-O-(1,2-saturated-alkyl)-sn-glycerol + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 = a 1-(1-hydroxyalkyl)-sn-glycerol + (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:36255"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="ChEBI" id="CHEBI:59560"/>
            <dbReference type="ChEBI" id="CHEBI:73418"/>
            <dbReference type="ChEBI" id="CHEBI:83957"/>
            <dbReference type="EC" id="1.14.16.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the sterol desaturase family. TMEM195 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.16.5" evidence="11"/>
    <dbReference type="EMBL" id="RQTK01001244">
        <property type="protein sequence ID" value="RUS71260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SPW1"/>
    <dbReference type="STRING" id="188477.A0A433SPW1"/>
    <dbReference type="OrthoDB" id="6354873at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050479">
        <property type="term" value="F:glyceryl-ether monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006643">
        <property type="term" value="P:membrane lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056853">
        <property type="entry name" value="AGMP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051689">
        <property type="entry name" value="Sterol_desaturase/TMEM195"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21624:SF1">
        <property type="entry name" value="ALKYLGLYCEROL MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21624">
        <property type="entry name" value="STEROL DESATURASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24858">
        <property type="entry name" value="AGMP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="15">
        <location>
            <begin position="31"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Alkylglycerol monooxygenase C-terminal" evidence="16">
        <location>
            <begin position="250"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF24858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RUS71260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="364" mass="42267" checksum="45C89163744D881F" modified="2019-05-08" version="1" fragment="single">FLFRPVELVIYSWIYQNWRVVELPWNNPWVWFAAFLLTDLLYYWFHRISHESNIVWASHQVHHSSEDYNLSTALRQSAMQKYYSMFLYFLMAPFVPTPIFYVHQQFNLLYQFWIHTECIDTVGPLEYILNTPSHHRVHHGRNPYCIDKNYAGTLIIWDRLFNTFQAEGEKVVYGLVHPNTFWNPLYGQAVHYLYILGLVKQHKTVGDKVSAVVKGPGWGPGKPWTGLPGDVPQVEQPVRKYNSDLPLWANAYVVLHFLLVIATSSLVAPYKKEFGFLTGLGFVLFFVYSLTVFGALFDHRKYSSMMEFVRCVVCVAVAHHVRDTALFTLSFAGIVEIIFLASAALWGVLTLLQYNVHMITKKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SQ70</accession>
    <name>A0A433SQ70_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_020846</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001221">
        <property type="protein sequence ID" value="RUS71391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SQ70"/>
    <dbReference type="STRING" id="188477.A0A433SQ70"/>
    <dbReference type="OrthoDB" id="449487at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07723">
        <property type="entry name" value="hydroxyacylglutathione_hydrolase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035680">
        <property type="entry name" value="Clx_II_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032282">
        <property type="entry name" value="HAGH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935">
        <property type="entry name" value="BETA LACTAMASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935:SF116">
        <property type="entry name" value="HYDROLASE PNKD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16123">
        <property type="entry name" value="HAGH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="7">
        <location>
            <begin position="61"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="322"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS71391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="376" mass="41741" checksum="952BE96A651050F8" modified="2019-05-08" version="1">MGSCMFKAGYTLYADTCIGRCIHNRIIANFQKQFGENAMHSKLTPFVFQELLILPIPVLVNNYAYLVADLSDHIFILVDVGDATIIKRMQVQPEAVLTTHKHWDHSGGNRLMRSTFPGLKVYGGVLDHVPDSTHNVNDGQELRFGKLKFTAMWTPGHTKGHTVWRLDGSDFGCADSVFTGDLLMLGGCGAAFEGPVRQLAASLDMMKALPEETMVWPGHELALENLELAVFIEPENISALLKLVWAFNRREAKVCTCPSTIGEEKSYNPFLRTQDPQMLAALGIAERVRCPNHPMTSDQINELSFDMIIAYSAKMSQLKRAMRHAQQERNRDQRAAQPTAANNAEPQLPQAESPRAAALSITYKAGNQKVTETIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SR83</accession>
    <name>A0A433SR83_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_020483</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001165">
        <property type="protein sequence ID" value="RUS71752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SR83"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS71752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="104" mass="11853" checksum="5CAAF5B596819CB2" modified="2019-05-08" version="1">MLLCCDFCQDVCTATLDKSIIKKIGFCSLINSYYCLRKGQITSFFFKYNVFLEETNLSRLTEIKSLHLTLSVTIDLINSDSDSRLCSRSQAHLCLGLIIRRCVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SSR8</accession>
    <name>A0A433SSR8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fibronectin type III-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_019916</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001081">
        <property type="protein sequence ID" value="RUS72324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SSR8"/>
    <dbReference type="STRING" id="188477.A0A433SSR8"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721:SF42">
        <property type="entry name" value="FIBRONECTIN TYPE III-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="SUGAR HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019523506" description="Fibronectin type III-like domain-containing protein" evidence="4">
        <location>
            <begin position="24"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="5">
        <location>
            <begin position="697"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS72324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="793" mass="88341" checksum="F299DEA12BEF9CF3" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SV63</accession>
    <name>A0A433SV63_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sushi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_019064</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000969">
        <property type="protein sequence ID" value="RUS73172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SV63"/>
    <dbReference type="STRING" id="188477.A0A433SV63"/>
    <dbReference type="OrthoDB" id="6160091at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051277">
        <property type="entry name" value="SEZ6_CSMD_C4BPB_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45656">
        <property type="entry name" value="PROTEIN CBR-CLEC-78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45656:SF4">
        <property type="entry name" value="PROTEIN CBR-CLEC-78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="91"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="204"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS73172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="28817" checksum="0C7D7BCF5D4486A8" modified="2019-05-08" version="1" fragment="single">VSFQFQELALDPEDKLTVYDGAGRTAPVITHIDGLYGAQSPTVDRDVDSLVAGASVRRPPLIVSSGNRLFVSLSTAGGGSRKIVAKYVQGCDLVVRHTDPVLILSPGYGVTKYPALRNCSWTVQGSNARRNLIFLPQFHTEPANDVVKVYNSLSPHKVTLLATLSGSSLSQTQAKHTSQSGDFHITFQTDQFVSQGSWAALISTDCNRLEEPHLRADVTDTSFGARVELSCEDGYYLNGDSARTCWLGGRWFPDHAPVCKDITCGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SW60</accession>
    <name>A0A433SW60_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_018816</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000938">
        <property type="protein sequence ID" value="RUS73428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SW60"/>
    <dbReference type="STRING" id="188477.A0A433SW60"/>
    <dbReference type="OrthoDB" id="7763451at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343:SF22">
        <property type="entry name" value="LD29830P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343">
        <property type="entry name" value="SERINE/ARGININE-RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="8"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="162"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="268"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="352"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="394"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="430"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="465"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="486"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="547"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="579"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="598"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS73428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="614" mass="70016" checksum="5B08B8307F0EB3A4" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SZQ7</accession>
    <name>A0A433SZQ7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_017475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000801">
        <property type="protein sequence ID" value="RUS74777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SZQ7"/>
    <dbReference type="OrthoDB" id="6161758at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="398"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="484"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="638"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="767"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1140"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="976"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="498"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="781"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS74777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1179" mass="127053" checksum="E462B5D4CB34E297" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SZT4</accession>
    <name>A0A433SZT4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vitellogenin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_017409</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000795">
        <property type="protein sequence ID" value="RUS74819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SZT4"/>
    <dbReference type="STRING" id="188477.A0A433SZT4"/>
    <dbReference type="OrthoDB" id="6484170at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.230.10">
        <property type="entry name" value="Lipovitellin, beta-sheet shell regions, chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015819">
        <property type="entry name" value="Lipid_transp_b-sht_shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015816">
        <property type="entry name" value="Vitellinogen_b-sht_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050733">
        <property type="entry name" value="Vitellogenin/Apolipophorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001747">
        <property type="entry name" value="Vitellogenin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345:SF15">
        <property type="entry name" value="VITELLOGENIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345">
        <property type="entry name" value="VITELLOGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01347">
        <property type="entry name" value="Vitellogenin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56968">
        <property type="entry name" value="Lipovitellin-phosvitin complex, beta-sheet shell regions"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51211">
        <property type="entry name" value="VITELLOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0758">Storage protein</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019396641" description="Vitellogenin domain-containing protein" evidence="4">
        <location>
            <begin position="18"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Vitellogenin" evidence="5">
        <location>
            <begin position="40"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS74819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="297" mass="33335" checksum="7D9F6767BCF3551D" modified="2019-05-08" version="1">MEPRLLALLALASVAFAVPIKVPQTNDCATQCKASTKMNYNKGTTYVYDYRVDYSTSMSGASEDSAKLTLTTKAELEVLGPCEMALSLRDTRLFHSDAMGGLKAADGEDNFRRGLEASALRFSYGDGAVEHICTATREEPWVMNVKKGILSAFQNNMDDLRTDQNVTETDVTGTCKTEYKAIDRGYYADTVRKTKDVLSCMDRNDYKTILQMVPYTESSDLQGNPLMKTTHECDQVIERGSYLKSTKCKETHVYRPFSNGQDGVTTFVEQTLTYSTYKQSGYTRKGSFWRCLFVNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T231</accession>
    <name>A0A433T231_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_016621</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000724">
        <property type="protein sequence ID" value="RUS75628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T231"/>
    <dbReference type="STRING" id="188477.A0A433T231"/>
    <dbReference type="OrthoDB" id="769138at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000006">
        <property type="entry name" value="Cyclin I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="3">
        <location>
            <begin position="49"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS75628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="334" mass="37936" checksum="62E15FED2B539D31" modified="2019-05-08" version="1">MDRLSSGLDARRVMHMLSSNLEKERQLSERNIRLSNKTITEQQRDEAATWLTHLAAQFRFLPETCGLAVLLMDRVLLLVKVQAKYLQCVAVTCLFLAAKSLEEDENIPPTPDFVRKSRCGCSFSEISRMEMVILSKLDWNIRMPSAVDFLHTIHAVVVLHYPHLLSSLSDTSPSEHLTVVMRRLIRCLTWHGVLQFRPSTVALALISLELEQITPGWLRLVHVLQRMTNVGSEQLMLCREEIAGFLGQQLITMHAYRSRKSSSSAPSSKKRKVDHSATPAEEDNIYDGIKRLYNEDIVSVAMDKPPLRTSCSLEMHQDSEENAKLKSQTTLLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T3S4</accession>
    <name>A0A433T3S4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_016078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000683">
        <property type="protein sequence ID" value="RUS76166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T3S4"/>
    <dbReference type="OrthoDB" id="6101031at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS76166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="22697" checksum="2F43EC462854FAA1" modified="2019-05-08" version="1">MLSLTCIVFGMASSQWIRVRASLFSNDLGIMRHCDVVSQYCGDMERLNDLVDAQYASLFRSLQAVYLMHCVGMLISAVVYFLFAVKFFESKGGFRALTAFNFLTLAAGVYTLALFGTKYRQFFGLTSPLYDNNIIFSKDGHDSHHVSDFGYGFIMAIIGCVLSAIVTVCSGMEASRAVDLLRNMQNRLTVWTSPYTLFVDQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T4A4</accession>
    <name>A0A433T4A4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_015823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000664">
        <property type="protein sequence ID" value="RUS76413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T4A4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS76413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="204" mass="23041" checksum="11CC0D7F6D3F2B25" modified="2019-05-08" version="1">MSFHFQRQDGGYPIEEVKSSLAFMEMKTIWRAFRVYCLTVIETNALFPSLLSRPRALLLHFVNLWALKVPSLFLKPCEAECRAAAPPTHLRPIRADPFPIETTRPLSGGIQRFSVSVSRAIGHSDTRTLGHMDSPPLSLAPDGHLSGQWSVHSLDMSTSQRGQQVWEILDADLISAAGHCDVTSAWSDRAWRHRGDIRVVEWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T4J6</accession>
    <name>A0A433T4J6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">YLP motif-containing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Nuclear protein ZAP3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EGW08_015712</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">EC2010</strain>
            <tissue evidence="15">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in the reduction of telomerase activity during differentiation of embryonic stem cells by binding to the core promoter of TERT and controlling its down-regulation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with PPP1CA and NCOA5. Forms a complex with ILF2, ILF3, KHDRBS1, RBMX, NCOA5 and PPP1CA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000656">
        <property type="protein sequence ID" value="RUS76519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A433T4J6"/>
    <dbReference type="OrthoDB" id="513595at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032204">
        <property type="term" value="P:regulation of telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000399">
        <property type="entry name" value="YLP motif containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058903">
        <property type="entry name" value="Spectrin_YLPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026314">
        <property type="entry name" value="YLP_motif_con_p1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13413">
        <property type="entry name" value="YLP MOTIF CONTAINING PROTEIN NUCLEAR PROTEIN ZAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13413:SF0">
        <property type="entry name" value="YLP MOTIF-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26583">
        <property type="entry name" value="Spectrin_YLPM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="YLPM1-like spectrin repeat" evidence="14">
        <location>
            <begin position="181"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="81"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="245"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="727"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="835"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="917"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1445"/>
            <end position="1464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1668"/>
            <end position="1706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="257"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="328"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="379"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="454"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="548"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="586"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="624"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="639"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="744"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="768"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="891"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="917"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="973"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1058"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1077"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1144"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1154"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1227"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1251"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1357"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1452"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1683"/>
            <end position="1699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00058677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF26583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RUS76519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1817" mass="206473" checksum="95E15C0593790000" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T589</accession>
    <name>A0A433T589_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GrpE protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_015528</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GrpE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000642">
        <property type="protein sequence ID" value="RUS76701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T589"/>
    <dbReference type="STRING" id="188477.A0A433T589"/>
    <dbReference type="OrthoDB" id="201635at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.22.10:FF:000002">
        <property type="entry name" value="GrpE protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.20.20:FF:000003">
        <property type="entry name" value="GrpE protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="GRPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237:SF23">
        <property type="entry name" value="GRPE PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="Coiled-coil domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS76701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="25704" checksum="2ACEE594B351D6B1" modified="2019-05-08" version="1">MATTGAAVRVFGMSSRLIRGFMPNNGLSTNSRCLCRNVTTATSDGSKPDANPPNPVESEDNTETLVKEKEKLASQIEKLQEDLKSSKDKYVRSLAEAENIRTRMGKQIEDAKLFGIQGFCKDLLEVSDILGTAVSSVPKEELTDSNPHLVNLYQGLNMTESQLIKVFKKHGLESIKPSEGEKFDPHFHEALFQVPIQSTETQEADTVAVVQKIGFKLHKRTLRPALVGVFKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T5T7</accession>
    <name>A0A433T5T7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_015328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000624">
        <property type="protein sequence ID" value="RUS76925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T5T7"/>
    <dbReference type="OrthoDB" id="10545046at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="645"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="694"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS76925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="723" mass="79462" checksum="58E191458A02AC5C" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T674</accession>
    <name>A0A433T674_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_015198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000615">
        <property type="protein sequence ID" value="RUS77041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T674"/>
    <dbReference type="STRING" id="188477.A0A433T674"/>
    <dbReference type="OrthoDB" id="5978526at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34615">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34615:SF1">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS77041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="534" mass="62203" checksum="845E1D33914ACB1C" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T7H0</accession>
    <name>A0A433T7H0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_014750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000576">
        <property type="protein sequence ID" value="RUS77503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T7H0"/>
    <dbReference type="STRING" id="188477.A0A433T7H0"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS77503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="202" mass="22585" checksum="3825C412854D79B2" modified="2019-05-08" version="1">MEYQVGREYQVGWNINWDGMSSGIEYQVGWNIKWDGISSGMEYQVGRNIKWDGISSGMGYQVGWNINWDGISSGMEYQVGWNIKWNRISSGMEYQVGWNIKCDGISSVMEYQVGWDIKWDGIPSGMEYQVGWNIKWEPGKKCTTDSDCDGALKELSGKCDLTKGRCICADGYSATGDKCDGVAQLAASILLVLVAAIFTRLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T8Q9</accession>
    <name>A0A433T8Q9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_014248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000539">
        <property type="protein sequence ID" value="RUS77987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T8Q9"/>
    <dbReference type="STRING" id="188477.A0A433T8Q9"/>
    <dbReference type="OrthoDB" id="10503322at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35151">
        <property type="entry name" value="ELONGATION FACTOR 1 BETA CENTRAL ACIDIC REGION EUKARYOTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35151:SF2">
        <property type="entry name" value="ELONGATION FACTOR 1 BETA CENTRAL ACIDIC REGION EUKARYOTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS77987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="408" mass="53468" checksum="993D393CBFDD8B9D" modified="2019-05-08" version="1">MKWFPFNTMKWFPFTTMKWFPFNTMKWFPFTTMKWFPFNTMKWFPFTTMKWFPFNTMKWFPFTTMKWFPFNTMKWFPFTTMKWFPFNTMKWFPFTTMKWFPFNTMKWFPFTTMKWFPFNTMKWFPFTTMKWFPFNTMKWFPFTTMKWFPFNTMKWFPFTTMKWFPFNTMKWFPFTTMKWFPFNTMKWFPFTTMKWFPFNTMKWFPFTTMKWFPFNTMKWFPFTTMKWFPFNTMKWFPFTTMKWFPFNTMKWFPFTTMKWFPFNTMKWFPFTTMKWFPFNTMKWFPFTTMKWFPFNTMKWFPFTTMKWFPFNTMKWFPFTTMKWFPFNTMKWFPFNTMKWFPFNTMKWFPFNTMKWFPFNTMKWFPFNTMKWFPFNTMKWFPFNTMKWFPFNTMKWFPFNTMKWFPFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T975</accession>
    <name>A0A433T975_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_014108</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000531">
        <property type="protein sequence ID" value="RUS78135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T975"/>
    <dbReference type="STRING" id="188477.A0A433T975"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14017">
        <property type="entry name" value="STKc_TTBK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000481">
        <property type="entry name" value="Asator, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000358">
        <property type="entry name" value="Tau tubulin kinase 2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047916">
        <property type="entry name" value="TTBK_Asator-like_STKc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="588"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="696"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="384"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="620"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="696"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="734"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="765"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="836"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="959"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS78135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="971" mass="106432" checksum="D13F840801EB00A1" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TA75</accession>
    <name>A0A433TA75_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_013874</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000515">
        <property type="protein sequence ID" value="RUS78354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TA75"/>
    <dbReference type="OrthoDB" id="6138985at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038875">
        <property type="entry name" value="PLA2_conodipine-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37687">
        <property type="entry name" value="AGAP006772-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37687:SF1">
        <property type="entry name" value="AGAP006772-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019478671" evidence="2">
        <location>
            <begin position="22"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS78354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="706" mass="78269" checksum="C01AFB8FD7C291AF" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TAQ0</accession>
    <name>A0A433TAQ0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_013560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000496">
        <property type="protein sequence ID" value="RUS78672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TAQ0"/>
    <dbReference type="OrthoDB" id="6137119at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="573"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS78672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="862" mass="94534" checksum="F78C3A2063EEC5FE" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TCS3</accession>
    <name>A0A433TCS3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_012834</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000452">
        <property type="protein sequence ID" value="RUS79421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TCS3"/>
    <dbReference type="STRING" id="188477.A0A433TCS3"/>
    <dbReference type="OrthoDB" id="10028801at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="99"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS79421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="205" mass="23187" checksum="EDC9060A3AEC67BF" modified="2019-05-08" version="1" fragment="single">MTVLVHTNITMKCVLQDLQGDVQWTKDGFGFSFNRSVPGQPRISITGNDQGYVRSFNLHITDVQLSDDDKYTCQVSPGHDTPPLIARATLTVTAPPEEPFIENYSNNSKVEVHYNSSSVQLVCVARAGKPAVNIFWYRDGQRVTENIEYETIPLTPSKKVTARSKLTISLDNYREENQRQYKCEVQRGPLWTEPLRPAVVTLDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TD55</accession>
    <name>A0A433TD55_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ZSWIM1/3 RNaseH-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_012807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000451">
        <property type="protein sequence ID" value="RUS79430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TD55"/>
    <dbReference type="STRING" id="188477.A0A433TD55"/>
    <dbReference type="OrthoDB" id="92090at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052579">
        <property type="entry name" value="Zinc_finger_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048324">
        <property type="entry name" value="ZSWIM1-3_RNaseH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21056">
        <property type="entry name" value="ZSWIM1-3_RNaseH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZSWIM1/3 RNaseH-like" evidence="1">
        <location>
            <begin position="23"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS79430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="235" mass="27907" checksum="40AE2508CCA6D05C" modified="2019-05-08" version="1">MEQVKTMLRMKANKKLLQQHIRKETGRCSFEVVEKEGVLQALFYQRTEWQHIYKKYPEVILIDATYKLNDLRMPLYLILCVDGNGESEVVAMWLVSSEDKVTMKAMIGFFIKHNGGEKTTCVMANKDWVERDVIKEELPHASLLICLFHMLRSFCREVSEKSMCFTQDQRQQALEFLERLAYSANEQQYFKHRDALLALGLHNVIDYFLKQWDNIRHEWVEGLKKQCQPFVEQYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TDW2</accession>
    <name>A0A433TDW2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Voltage-gated hydrogen channel 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Hydrogen voltage-gated channel 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EGW08_012481</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">EC2010</strain>
            <tissue evidence="17">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000429">
        <property type="protein sequence ID" value="RUS79765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TDW2"/>
    <dbReference type="STRING" id="188477.A0A433TDW2"/>
    <dbReference type="OrthoDB" id="427456at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030171">
        <property type="term" value="F:voltage-gated proton channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031846">
        <property type="entry name" value="Hvcn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46480">
        <property type="entry name" value="F20B24.22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46480:SF1">
        <property type="entry name" value="VOLTAGE-GATED HYDROGEN CHANNEL 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="16">
        <location>
            <begin position="54"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="266"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="174"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RUS79765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="292" mass="32675" checksum="72B915D8FBC036CC" modified="2019-05-08" version="1">MAIDGLETMDSDLERIIKKHRGDGDSQSASAGVFKAEPEDLRTRLDHLIHSHMFMVGVIVLVVLDCLMVVAELLFDLEIVKLGDDHHFIPHIFHYCSLAILSLFLIEVGMRIFVLRLDFLKHKLEVLDAVVVVVSWVLDIVFRDNEDAAAGVGLLIILRLWRITRIINGIVLSVQKQAEQKIEKEKHLREAAEQDLSGYSIYCKAIETRMKELEELLQKQGVDFSSVAKVTVEKPKERPQEAVEKKKGGKEAVDETVQELNEIVSKVNEMGSTETQHGGGDDSGSNGKNAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TJN2</accession>
    <name>A0A433TJN2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EGW08_010475</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">EC2010</strain>
            <tissue evidence="15">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000321">
        <property type="protein sequence ID" value="RUS81783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TJN2"/>
    <dbReference type="STRING" id="188477.A0A433TJN2"/>
    <dbReference type="OrthoDB" id="9996086at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027430">
        <property type="entry name" value="Retinal_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00238">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0157">Chromophore</keyword>
    <keyword evidence="8 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="10 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="11 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RUS81783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="237" mass="26425" checksum="77169B319A0C25F8" modified="2019-05-08" version="1" fragment="single">STACELYGLVGGVFGIMSINTLAVIAFDRYNVIARPIKASRTLSYKRAFMMLMVVWTWSSAWPLPPLFGWGAYIPTMTSTLAGSDRMFLTTPAGGFQTSCTFDYLTMDQSTRSYILCLYILGFAVPLAIIMFCYYHIYSAVAAHEKEMGKMAKKLNAEIRQGQSAKKSEIKTARIAMTIIITFLLSWTPYATVALIAQFGPQELITPYVSELPVMFAKASAMHNPLIYALSHPKFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TJP7</accession>
    <name>A0A433TJP7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_010505</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000322">
        <property type="protein sequence ID" value="RUS81751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TJP7"/>
    <dbReference type="STRING" id="188477.A0A433TJP7"/>
    <dbReference type="OrthoDB" id="18853at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034993">
        <property type="term" value="C:meiotic nuclear membrane microtubule tethering complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052403">
        <property type="entry name" value="LINC-complex_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47535">
        <property type="entry name" value="MUSCLE-SPECIFIC PROTEIN 300 KDA, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47535:SF1">
        <property type="entry name" value="NESPRIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="7">
        <location>
            <begin position="71"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS81751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="450" mass="51061" checksum="E71162203D9FAE2B" modified="2019-05-08" version="1">MKHIMGIHGTGEQNENGEFFTEFCSFHDLRWVTPHWSGGEAVRAAPGSGHVPLVHQACWSLLVTADEQERVQKKTFTNWMNTYLCQRNPAIKVENLFEEVKDGVVLLSLLEVLSGEKLNGVSEKHFDRQQLTPVVDSQTYPCPWCKEPETCHAVQATPVLDSQTYSCLWYKEPKTYHAVQATPVLDSQTYSCPWYKEPETCHAVQATPVLDSQTYSCLWYKEPETCHAVQATPVLDSQATPVLDSHTYSCLWYKEPETCHAVQATPVLDSQATPVLDSQTYSCLWYKEPKTCHAVQATPVLDSHTYSCLWYKEPKTCHAVQATPVLDSQATPVLDSHTYSCPWYKEPETCHAVQATPVLDSQTYSCPWYKEPETCHTVQATPVLDSQTYSCLWYKEPETCHTVQATPVLDSQTYSCPWYKEPETCHTVQAHMRISHVTFKAARLPYSMCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TKC3</accession>
    <name>A0A433TKC3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_010301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000313">
        <property type="protein sequence ID" value="RUS81956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A433TKC3"/>
    <dbReference type="OrthoDB" id="6061841at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16897:SF2">
        <property type="entry name" value="OS03G0226600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16897">
        <property type="entry name" value="OS10G0105400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="2614"/>
            <end position="2716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS81956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="3533" mass="387167" checksum="C5A7DABCE3588B53" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TL13</accession>
    <name>A0A433TL13_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_009965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000293">
        <property type="protein sequence ID" value="RUS82287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TL13"/>
    <dbReference type="STRING" id="188477.A0A433TL13"/>
    <dbReference type="OrthoDB" id="6098511at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF1">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS82287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="127" mass="14953" checksum="3B0FDA7824101C8D" modified="2019-05-08" version="1" fragment="single">FSFFRETYHGRIETSTPYLFLTFPPWFERKYPELIKTLKINQNRLSSHYDVYETMKDILFLKGHKRPEGTVQERGISLFREIPKARTCRNAGIPDEFCACGKFQEPKVTRETISILGITLLNKINSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TMY7</accession>
    <name>A0A433TMY7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_009284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000264">
        <property type="protein sequence ID" value="RUS82947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TMY7"/>
    <dbReference type="OrthoDB" id="6517071at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="924"/>
            <end position="1059"/>
        </location>
    </feature>
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        <location>
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            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="350"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="435"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="486"/>
        </location>
    </feature>
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        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="622"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="985"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1047"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS82947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1059" mass="113733" checksum="6CB21207E1E13E2C" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TNL9</accession>
    <name>A0A433TNL9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_009073</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000255">
        <property type="protein sequence ID" value="RUS83173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TNL9"/>
    <dbReference type="OrthoDB" id="6154172at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS83173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="196" mass="22117" checksum="FA19920A33E3BBEA" modified="2019-05-08" version="1">MTPSITRTRTIQNRTLIWARWGLVCQILEIALSGENNNDTVSYFIFLTGFSAPLEITIDADIPSGMEKVIAEDNQNALQDENNPSANCSRISVLQCNSEIFKNKSQGQKQGIVHFKLSKTPSLRDSLQSSSILNVCLPQRQTNQLNNWQTVSLCSRTAHMFWICTGRHAFRGKLKQEYFSLRRALHPSGCVSTIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TQE4</accession>
    <name>A0A433TQE4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_008410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000228">
        <property type="protein sequence ID" value="RUS83829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TQE4"/>
    <dbReference type="STRING" id="188477.A0A433TQE4"/>
    <dbReference type="OrthoDB" id="2104158at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027912">
        <property type="entry name" value="CFAP54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33487">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33487:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14858">
        <property type="entry name" value="CFAP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="535"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS83829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="735" mass="82482" checksum="83D7B6E121FF7211" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TR19</accession>
    <name>A0A433TR19_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-formylglutathione hydrolase</fullName>
            <ecNumber evidence="3">3.1.2.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Esterase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_008242</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Serine hydrolase involved in the detoxification of formaldehyde.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the esterase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.12" evidence="3"/>
    <dbReference type="EMBL" id="RQTK01000222">
        <property type="protein sequence ID" value="RUS83981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TR19"/>
    <dbReference type="STRING" id="188477.A0A433TR19"/>
    <dbReference type="OrthoDB" id="6121068at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018738">
        <property type="term" value="F:S-formylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014186">
        <property type="entry name" value="S-formylglutathione_hydrol"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061:SF0">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0719">Serine esterase</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS83981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="122" mass="13743" checksum="072C2E30D70130C1" modified="2019-05-08" version="1" fragment="single">LNPGLFSSVSAFAPIANPTECPWGHKCFGGYLGANKEAWKAYDATVLVRSYDGPPLDILIDQGAADNFLTEKQLLPEKFIEACKDSNVPCVLRMKEGYDHSYFFIATFMEDHMRHHAKHLHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TTL7</accession>
    <name>A0A433TTL7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_007317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000189">
        <property type="protein sequence ID" value="RUS84907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TTL7"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS84907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="211" mass="24936" checksum="41F3FC91DE907D84" modified="2019-05-08" version="1">MLDVEPSQQAPIKALSETYEANERSDNDVIMLSVNFLCVVKSVILATGTGRKKTKKRWEKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKEKGDRDGEEEGEEEGEGRPRRRRRRRRRRENETEKKEKKKETGERDGEGEYHIHKSHPDDTMMRANARKRRVLYTTVSSPSWSLLPPRLASLPPSLPHVRYSPRSVDKLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TVE3</accession>
    <name>A0A433TVE3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">EGW08_006754</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">EC2010</strain>
            <tissue evidence="19">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HRD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="RQTK01000168">
        <property type="protein sequence ID" value="RUS85478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TVE3"/>
    <dbReference type="STRING" id="188477.A0A433TVE3"/>
    <dbReference type="OrthoDB" id="7759664at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16479">
        <property type="entry name" value="RING-H2_synoviolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000088">
        <property type="entry name" value="E3 ubiquitin-protein ligase synoviolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057992">
        <property type="entry name" value="TPR_SYVN1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058051">
        <property type="entry name" value="Znf_RING_synoviolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF184">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SYNOVIOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25563">
        <property type="entry name" value="TPR_SYVN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="235"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="282"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="498"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="339"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="353"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="511"/>
            <end position="523"/>
        </location>
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        <location>
            <begin position="536"/>
            <end position="545"/>
        </location>
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        <location>
            <begin position="560"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="582"/>
            <end position="604"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="612"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RUS85478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="648" mass="72677" checksum="9F28833438B1FE0E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TX24</accession>
    <name>A0A433TX24_ELYCH</name>
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        <recommendedName>
            <fullName evidence="4">Nose resistant-to-fluoxetine protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_006099</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000149">
        <property type="protein sequence ID" value="RUS86151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="118951at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00703">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019165683" description="Nose resistant-to-fluoxetine protein N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="28"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="492"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="726"/>
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        <location>
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            <end position="767"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="844"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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        <location>
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        <location>
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            <end position="415"/>
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            <begin position="391"/>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00703"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RUS86151.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="940" mass="104246" checksum="7011F013873B06CB" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TYJ3</accession>
    <name>A0A433TYJ3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mesoderm induction early response protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_005638</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Lophotrochozoa</taxon>
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            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000133">
        <property type="protein sequence ID" value="RUS86622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TYJ3"/>
    <dbReference type="STRING" id="188477.A0A433TYJ3"/>
    <dbReference type="OrthoDB" id="5916873at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="SANT_MTA3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Metastasis-associated 1 family, member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000949">
        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040138">
        <property type="entry name" value="MIER/MTA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10865:SF28">
        <property type="entry name" value="ELM2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10865">
        <property type="entry name" value="METASTASIS-ASSOCIATED PROTEIN AND MESODERM INDUCTION EARLY RESPONSE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01448">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ELM2" evidence="7">
        <location>
            <begin position="148"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="8">
        <location>
            <begin position="252"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="48"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="115"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="362"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="134"/>
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    </feature>
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        <location>
            <begin position="368"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="398"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="506"/>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51156"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51293"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="584" mass="64028" checksum="D508546D12DD8D85" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-05-03" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TYR3</accession>
    <name>A0A433TYR3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_005514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000130">
        <property type="protein sequence ID" value="RUS86724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TYR3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="246"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS86724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="459" mass="51715" checksum="51A1CA72866CDAD0" modified="2019-05-08" version="1">MMATPAQSQIDSLLQDLATAASSTFISNGAVIFHILNTNSESKFKKKDFGRTTEVICCLIGENTPNGPEPNKIRLKCKDTYNRFCQLKKHMSQPSAWSKLVDFLSREFYRQTVTSVQLDHIYEAREVDELPEPTAGPLFHVTLNTPLSQHVTSHPPSPKKLKGDCENCANRRQSLKVQTEALRNQKSIAYTLRRQKADMTRVYGKRTIDQRHRRHKIRVKTLVGHNKELLSKIEKLEKSGFFSVRKKKLLMKNDTLERENANLKHEVSILKEKVQKLEEECRHLHFQFADQEMMSNTSSSSNTVEAKEGKSFSRPIRESVYLMLCRQVPVEACGPVLKTILAKVANKTLTAIPFPSTCAQMSYELGISSLQVASHLMEAENGCLSWDATSVDGSHKELNCELIELHCNVHPMDAFANRSKAQLTAIDAQHDTAGKCYGKEGCAANLIQAVAYTYINSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U256</accession>
    <name>A0A433U256_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_004358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000098">
        <property type="protein sequence ID" value="RUS87880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U256"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS87880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="107" mass="12617" checksum="CF4E51AF9EC01000" modified="2019-05-08" version="1">MPNGEKYLLCQLCVLIRFQLRKMAEQRKFIFISVNLRKMCWPHFQQTSIICLSLKEKILINLCMMLNVLIIMTVVLIKGGVFSGQFMKVCLSISACQFYYLEKEKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U3R0</accession>
    <name>A0A433U3R0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_003782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000082">
        <property type="protein sequence ID" value="RUS88445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U3R0"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS88445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="218" mass="24220" checksum="8A6107870EFC5412" modified="2019-05-08" version="1">MIGRRCRFPHIIVVFVFVIGPYRKTCNVDLRVPRPALHVEPTEIRPFRSPGGKDQREASPCSRPIYSSETKHAIQAARASKWRTNLPVSGALRAVSLVRNMADMSHLQPDGWTIRGQCGDNSATIPRQYPAGKSSGLGAKSCRELYTVYTRLLSWRSGNTRTPCLGCREPAYLWAYRARWSVRMEANGSRGTWNPRGGEGVGGAGRGKRSKHASAKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U4D5</accession>
    <name>A0A433U4D5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_003607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000077">
        <property type="protein sequence ID" value="RUS88648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U4D5"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS88648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="201" mass="22913" checksum="933D8AA9877A03DE" modified="2019-05-08" version="1">MKSKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKCGSVSEQTRRCAKNVCSARVCSVSEQVPCAVCKQSRKYPGEKPPRGRQSVPPPKTLSKGSSRVDVHPLRGNMVERAAPRHTSQVLSHDLLISSNFDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDGDGDDDELGKKYLSLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U5V0</accession>
    <name>A0A433U5V0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_003026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000062">
        <property type="protein sequence ID" value="RUS89216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U5V0"/>
    <dbReference type="OrthoDB" id="6149959at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS89216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="359" mass="40505" checksum="A806C3CB5BE10680" modified="2019-05-08" version="1">MEAARFKLDIAFQEKGESLHQWADRLKDIGFRIARGERGAYGAVEPRLVFKFCLAGLDKEAGHKVIETGPPSDLETAVERVQWLQHVESASRGRSWYEDSGKDYSRCGGNPHYWEDQDYRQRRDLVDKDYQRDSDGQEHQYRGPWSEEGRTVSPNFREQRTRDYSPAVCDVGRGVESPLETLMKTNLVQEVKGLGNSMESESKEPVTMDGCLQVIDSKVQTLERARRGSLSQSPHRRSPPHVEGSLPVPKPASLSSNHGVPGIMVGDEDDRCRPKIKGQVIACSGKCLGSREVMAGVRVGDEDDRYRPKIKGQVCIFSRKVLGSKENMPGSRVDSANVFRGLENDDGRCRPKLERDWWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U5W2</accession>
    <name>A0A433U5W2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein phosphatase inhibitor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_003036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein phosphatase inhibitor 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000062">
        <property type="protein sequence ID" value="RUS89226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U5W2"/>
    <dbReference type="STRING" id="188477.A0A433U5W2"/>
    <dbReference type="OrthoDB" id="551302at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1050">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007062">
        <property type="entry name" value="PPI-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398:SF20">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY INHIBITOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398">
        <property type="entry name" value="PROTEIN PHOSPHATASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04979">
        <property type="entry name" value="IPP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="19"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="137"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS89226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="16611" checksum="87259D7D9AA4E3D9" modified="2019-05-08" version="1" fragment="single">KEIEWDEMNILATYHPPDKDYGFMKVDEPPTPYNKAGVSDEEETTIERKGSVSSVPDLDPAALAERYVESMGYSETRKAFLLKRKMHYNEFQAVQLAKKLMAEEDDDDEDCDDAKGSFSEAPAPASKCISVDGVETSGKTQSGGASGSSSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U6X2</accession>
    <name>A0A433U6X2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_002681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000052">
        <property type="protein sequence ID" value="RUS89563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U6X2"/>
    <dbReference type="STRING" id="188477.A0A433U6X2"/>
    <dbReference type="OrthoDB" id="2722301at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="24"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS89563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="318" mass="35504" checksum="B76312E8FB9199FA" modified="2019-05-08" version="1">MASANPHETYGLHLQVDYFELFEFRVESHLGSGRSGDVYLACSERHEGITRAVKKASTKAEDLLVRGVSLQELKQKFYREVEILQSINFPCILRGVNLIVCPDYLAITMDYCERGPLSEGLSRVDNAKTYIISLYLIRALDYLHYHRIAHGDIKPSKILFAGFRENIRPVLAGFSAAFRLPQNSNMVRAYGQTPCYVAPEARRKSESVDALKCESFAMGTVMLCMALRTAPPPETDSYADVIKGLPGLCDGMRALMHGMVQDDPANRISISEANKLISCIDVEECRAAQVPINTANNEAVGRCHYTIPQAFFHIMCLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U7U6</accession>
    <name>A0A433U7U6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Neurotransmitter-gated ion-channel ligand-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_002321</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000045">
        <property type="protein sequence ID" value="RUS89880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U7U6"/>
    <dbReference type="STRING" id="188477.A0A433U7U6"/>
    <dbReference type="OrthoDB" id="6148344at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18989">
        <property type="entry name" value="LGIC_ECD_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="7">
        <location>
            <begin position="19"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="8">
        <location>
            <begin position="232"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS89880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="47945" checksum="5AC64742EBF2E48C" modified="2019-05-08" version="1">MLLLLVSPCQGGSYSQKKALHDALLSSSNYNPDQRPVLDQAHTLHVDVMFALVSIVEINDVIQNFRCNGFLGLFWTDEILRWNSSDYGGEVVMAPKITSVFRPRVIMLNTMENRDLFEDDYAPLSVMSDGSVDWAPGSIFPASCKLDLTKYPFDQQHCQIEMLAMNFNATELLFQPTSNFVGMNFFTENGQWDITNMSVSCPLRDIGSEQKSTVLVSFDLKRKPTFLVLSVLLPIVFLSLLNLLVFVIPVDSGEKISYGITVLLALSVFMSIMSSMLPSSSESMPLMISYIFILMIISVLTVVDSIIIVGLHHMEEKEEKSQKARTNFKSAMPKIGFLRKAVTPLNQTSPMVSEDPINQDELGLKVKPVSADDRTSPEKSAPPYESLTRSSEGPRVNKYKLIGKYIDLVSLAVFGVVWLSVTVGFMASMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U802</accession>
    <name>A0A433U802_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_002287</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000044">
        <property type="protein sequence ID" value="RUS89935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U802"/>
    <dbReference type="STRING" id="188477.A0A433U802"/>
    <dbReference type="OrthoDB" id="5847285at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14692">
        <property type="entry name" value="bZIP_ATF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000021">
        <property type="entry name" value="Cyclic AMP-dependent transcription factor ATF-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR ATF 4/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044:SF14">
        <property type="entry name" value="CRYPTOCEPHAL, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="297"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="260"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS89935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="368" mass="40837" checksum="1DB25F62F5BED9D0" modified="2019-05-08" version="1">MEMSLLNDDWGLDWPFHQENGLFGDLKFDSHVDGTDSSFQSHDAAEHSISSENAGDEGSLSLEWMESSDLSVYLNELDDKLVPLDSSLQEFTSLISPEQPAVWDQLNLNDNIAGLKTLTDVVSSEESVLSDVSFDALASSPESPEQVTPVIKFELCGLDHRNVFEESSLGSAEQSSGVLISEDILDQLQFSHINNLGESPVCLDPVVELISSPLSADDVDSLLSASEPASPSSLSFDKRSNVIKASPELYKIISTSSLNASKRTTPYPNSKPKKESRTPQRRTPAQPVPEHVILEQVNKKDRKKLQNKNAAIRYRQKKKDEALGIKSEEQILEETNSDLKTQVDDLEREIKYMKGLMHDIYKAKGLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U8K9</accession>
    <name>A0A433U8K9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Macroglobulin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_002095</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000039">
        <property type="protein sequence ID" value="RUS90128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U8K9"/>
    <dbReference type="STRING" id="188477.A0A433U8K9"/>
    <dbReference type="OrthoDB" id="6156464at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF136">
        <property type="entry name" value="CD109 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0882">Thioester bond</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019181807" description="Macroglobulin domain-containing protein" evidence="3">
        <location>
            <begin position="17"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS90128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="18967" checksum="59839A7CC7CB9580" modified="2019-05-08" version="1" fragment="single">MAVIVLLSAIVALALGQRVPLRPIPENINYVPTTPVPPVFNGTYWLTMSSKVRPGTAFQVSAQLLEGEDPVDVTVIFQDQFGKKNILESPAFTVTPGDIQTFGIAIPLDIEKPREVSDMYWYDISYNVLVKGVGRSINFKHAAQIKYEEKSFSTFIQTDKGMYKPGQKGGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UBS9</accession>
    <name>A0A433UBS9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanylate cyclase</fullName>
            <ecNumber evidence="2">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_000960</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="2"/>
    <dbReference type="EMBL" id="RQTK01000015">
        <property type="protein sequence ID" value="RUS91248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UBS9"/>
    <dbReference type="STRING" id="188477.A0A433UBS9"/>
    <dbReference type="OrthoDB" id="6127067at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008074">
        <property type="term" value="C:guanylate cyclase complex, soluble"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019934">
        <property type="term" value="P:cGMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070482">
        <property type="term" value="P:response to oxygen levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.260:FF:000002">
        <property type="entry name" value="guanylate cyclase soluble subunit alpha-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000007">
        <property type="entry name" value="Guanylate cyclase soluble subunit alpha-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.260">
        <property type="entry name" value="Haem NO binding associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042463">
        <property type="entry name" value="HNOB_dom_associated_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655">
        <property type="entry name" value="GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655:SF13">
        <property type="entry name" value="SOLUBLE GUANYLATE CYCLASE GCY-32-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="10">
        <location>
            <begin position="256"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS91248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="400" mass="44307" checksum="4F36D7F01170C787" modified="2019-05-08" version="1" fragment="single">GSATVSILNGSYLKPNTPKNTGRQKAASLDKTRQADGDSAEDMNPQPVTLTSDQLCTTFPYHLIFDRKLRLRQFGRTMARLSPVPLYTGLLVTSVFHVLFPRISFTVENILQFTNSIYILGVGPSPSGKQNGGAAESGLSLKGQMIWFAESEMMLFIGSPRLQSLTEMKRMNIYMSDIPLYDVTREMVLLYQQRNAEIDITKKLDETTAELKRTSRELALEKQLTDRLLYQMLPAKVADQLKLGMKVEAEKFDQVTVLFSDIVEFTSIAAACSPLDVVNMLNNLYHKFDVQTNEHGVYKVETIGDAYMVVSGVPEVTTTHAQNVADFALTMTRLARSVLTPDSGKPIKIRVGVHTGPVVAGVVGVKMPRYCLFGDTVNTASRMESHGVPARIHVSLSCFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z1Y1</accession>
    <name>A0A3S0Z1Y1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_023274</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001901">
        <property type="protein sequence ID" value="RUS68965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z1Y1"/>
    <dbReference type="STRING" id="188477.A0A3S0Z1Y1"/>
    <dbReference type="OrthoDB" id="434324at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052268">
        <property type="entry name" value="SAM_domain-containing_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20843:SF0">
        <property type="entry name" value="PROTEIN AVEUGLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20843">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="2">
        <location>
            <begin position="33"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS68965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="139" mass="16159" checksum="0D05D27AF1FE7CA7" modified="2019-04-10" version="1">MLGATLEARPTSYMDGFAVKRGMKGKTKPLHFWTSADVNKWLRKHGGLYFELYGDLLSKHEVTGRTLIRINDIKLERMGILDTTHRHDLMQFILRLRLKHEMSDLRNHYQRGSGFELKLPEARQSSMDKAPSDKFLSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z3C2</accession>
    <name>A0A3S0Z3C2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_022409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001562">
        <property type="protein sequence ID" value="RUS69831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z3C2"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48209">
        <property type="entry name" value="AGL056WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48209:SF2">
        <property type="entry name" value="FI24008P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS69831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="207" mass="23001" checksum="D70AD07F1FF1C326" modified="2019-04-10" version="1">MCPVAGLGQVYFDICLFCQGGEGRKGNDDNDNDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDGKRRRRRGMTNTANTERDLGACMPWGVCNSSLGKYLASVIARQSDTFLERSYSKEANKVEISVLGLGQLSARQALSVGGDNSSTQCHTEIGLDRGRKGNYETFHIILMFSVLMINYTGFKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z5Q9</accession>
    <name>A0A3S0Z5Q9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bridge-like lipid transfer protein family member 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_020961</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001241">
        <property type="protein sequence ID" value="RUS71277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S0Z5Q9"/>
    <dbReference type="OrthoDB" id="10051416at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033616">
        <property type="entry name" value="BLTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056742">
        <property type="entry name" value="BLTP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056741">
        <property type="entry name" value="BLTP1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047104">
        <property type="entry name" value="BLTP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31640:SF1">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31640">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN KIAA1109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25040">
        <property type="entry name" value="BLTP1_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25039">
        <property type="entry name" value="BLTP1_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20413">
        <property type="entry name" value="BLTP1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01220">
        <property type="entry name" value="FSA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="3447"/>
            <end position="3467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="3518"/>
            <end position="3536"/>
        </location>
    </feature>
    <feature type="domain" description="Bridge-like lipid transfer protein family member 1 C-terminal" evidence="3">
        <location>
            <begin position="4153"/>
            <end position="4735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1128"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1191"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1279"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1770"/>
            <end position="1790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2296"/>
            <end position="2316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2417"/>
            <end position="2453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2788"/>
            <end position="2826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3626"/>
            <end position="3673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3826"/>
            <end position="3879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="4033"/>
            <end position="4088"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="4106"/>
            <end position="4159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="4637"/>
            <end position="4657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="560"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1151"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1196"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1771"/>
            <end position="1790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2790"/>
            <end position="2816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="3626"/>
            <end position="3635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3636"/>
            <end position="3652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3662"/>
            <end position="3673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3859"/>
            <end position="3879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="4052"/>
            <end position="4061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="4144"/>
            <end position="4153"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS71277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="4756" mass="526702" checksum="03314E25D9DC2609" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z7V6</accession>
    <name>A0A3S0Z7V6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_019515</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001027">
        <property type="protein sequence ID" value="RUS72717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z7V6"/>
    <dbReference type="STRING" id="188477.A0A3S0Z7V6"/>
    <dbReference type="OrthoDB" id="6141373at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018682050" description="C-type lectin domain-containing protein" evidence="4">
        <location>
            <begin position="36"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="38"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="5">
        <location>
            <begin position="108"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="5">
        <location>
            <begin position="338"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS72717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="52705" checksum="3284A766DD466391" modified="2019-04-10" version="1">MKMQRVRSQAKGRFGCLCVLFLALASLSLPSPSLGADLMCSQPGPAPDGKPVGDVIKDSYAIGEEVTYKCDYSEATRIRSCETTGKWSPMGQVCSECPENFELNPEFGKCYYFPNILKSWVQGEAFCEQYGALMAFPENEAENLFLASFINYPTFIGITDRVQEGMFMTVTGIVPPYVNWNRGEPNNSGGGGEDCAENGGIGVWNDRNCENGELYFICQKDKLALHHCLDFLDNCAELFHANPNVCKTDPAFANSKCRFTCGVCGATSTPACRVDTPGAEAGDRQVLRRGQSLTLPCPEGMIPVSGSELRGCTATGYLSGHHLECAKSCPGEWTKNPANNFCYKLFPEKSEFVEAEAACAKIPGGLLTTAADEEELAFVSALRGSAGHIWIGLTDILVQGTYRWVDGTELTYKNWQRGEPNNRHERCVMMYTNTRWNDARCETKLPFVCKVGLEQFEEYAWFWSALRSGVSTLRSVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z860</accession>
    <name>A0A3S0Z860_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_020679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001196">
        <property type="protein sequence ID" value="RUS71561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z860"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS71561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="386" mass="43284" checksum="718495D4126867F4" modified="2019-04-10" version="1">MALVIDDEAREAELAICGELPFTTLVSGSKKGAVSVKKRKTITISSDDNDDSDGEKIGKGRIKEDRKIKREDETDSTWRLDVYTRNKMGYQPKGLRLTGYTITTYPRVCAQLDQPESKCLHITAQYRDGMELISKTQPSVSISLLSTEMVWSLYQRHSQVSPYHCSVQRWYGACIKDTAKAFRAVGGYCIGTKLQEMEETEANTQKPLLKGRKYFHSGHVQTMQDQKDNKKAVGGCCIGTEVQKPAAVGGCCIDTAVQIPASDAKPIIHTKGKKRSADEEVLIYLEERETNRPQERDGALRLRSVEAHTQYALREEEKEEKSKESLAAELIMTSFIVHQNMSFFATGISPECLRQAFKDSKIAAGKKRSADEEVLICLEEQETNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2024-03-27" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZB42</accession>
    <name>A0A3S0ZB42_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_017334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000788">
        <property type="protein sequence ID" value="RUS74903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZB42"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46155">
        <property type="entry name" value="BIFUNCTIONAL INHIBITOR/LIPID-TRANSFER PROTEIN/SEED STORAGE 2S ALBUMIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46155:SF1">
        <property type="entry name" value="BIFUNCTIONAL INHIBITOR_LIPID-TRANSFER PROTEIN_SEED STORAGE 2S ALBUMIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS74903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="179" mass="21228" checksum="4B9F0A0B4FC60DD5" modified="2019-04-10" version="1" fragment="single">MIQTMIQTMIQTMIQTMIQTMIQTMIQTMIQTMIQTMIQTMIQTMIQTMIQTMIQTMIQTMIQTMIQTMIQTMIQTMIQTMIQTMIQTMIQTMIQTMIQTMIQTMIQTMIQTMIQTMIQTMIQTMIQTMIQTMIQTMIQTMIQTMIQTMIQTMIQTMIQTMIQTMIQTMIQTMIQTMIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZBL4</accession>
    <name>A0A3S0ZBL4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Forkhead box protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_017087</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000767">
        <property type="protein sequence ID" value="RUS75147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZBL4"/>
    <dbReference type="STRING" id="188477.A0A3S0ZBL4"/>
    <dbReference type="OrthoDB" id="5402974at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20028">
        <property type="entry name" value="FH_FOXL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000016">
        <property type="entry name" value="Forkhead box protein I1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047515">
        <property type="entry name" value="FH_FOXL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF411">
        <property type="entry name" value="FORKHEAD BOX PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Fork-head" evidence="13">
        <location>
            <begin position="138"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="11">
        <location>
            <begin position="138"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS75147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="471" mass="49931" checksum="0979B7656D48372A" modified="2019-04-10" version="1">MNSSGNTNITSSSSSKRKYGGSESKQSSSKSQSHNNSERSGAKIQSQNTANYRGEKFVKSEPDSNKASLPSPSASPPTCDSEDKLSRDSTSSPQGTTTTGTATATTAATTTGATDTTRKSMTPNNKDNPESFKDPNIKPPYSYVALIAMAIKETPEKRLTLSGIYQFIINRFPYYEKNKKGWQNSIRHNLSLNECFVKVAREGGGERKGNFWTLDPAFEDMFEKGNYRRRRRMKRPYRPTLSLNKSFFSDPTHALNQFAFNSYFNTAPSYSQYSGYSPWALASHHHHHHHNTTAAAAAAAASAGPLGVTQLPSYRGCHQRFSNSAFNGLHAQYHGMGSMSAAVGMGSMGSMNAMGSMSSMGSMGSMGSMSSMGAALGAHAAGGTPTQVMATSPMASPGGYSTGAYTPHAQFSGHHDYPSAGSGAAAAATLGFQYGSGGSGGGGSTAAIRQAGDGFGSAHHYSSYWVGDRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZBS4</accession>
    <name>A0A3S0ZBS4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_020903</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001230">
        <property type="protein sequence ID" value="RUS71338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZBS4"/>
    <dbReference type="OrthoDB" id="6217214at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS71338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="518" mass="56660" checksum="1BA48658244CE4B4" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZBT7</accession>
    <name>A0A3S0ZBT7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_018144</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000866">
        <property type="protein sequence ID" value="RUS74097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZBT7"/>
    <dbReference type="STRING" id="188477.A0A3S0ZBT7"/>
    <dbReference type="OrthoDB" id="5981855at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004995">
        <property type="term" value="F:tachykinin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001681">
        <property type="entry name" value="Neurokn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46925">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR TKR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46925:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR TKR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00244">
        <property type="entry name" value="NEUROKININR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS74097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="318" mass="36911" checksum="975A62A1B5A3D484" modified="2019-04-10" version="1">MYQNWFFGLEYCKIDFFIAPLTISVSVLTFMAIAIDRYIAIIHPLRPRLPGYVVLSIISVIWVLSFLLALPNLLFATTYRMEDGRLVCWLEWPDSSAQGHSKQDFAYHILLMILNYFLPIITLTATYVRIGWELWGSKVIGETVPMQADRVKSKRKVVKMMIAVVVIFGLCWLPTHIYFILTSILTDIVYWRYIQQVYLLIYWLAMSNSMYNPIIYCLMNARFRQGFLRFFRWCPCSVCRRQHHLLTPERGALYSARLSMGSNAGGLIDKNGSVQHTTLDSMDENTLSTYRMVPLRSVSTLSTRTGNNNYTHIGHRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZC15</accession>
    <name>A0A3S0ZC15_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_018001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000852">
        <property type="protein sequence ID" value="RUS74233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZC15"/>
    <dbReference type="OrthoDB" id="10636879at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS74233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="156" mass="17389" checksum="5ED01D700B6FC6E5" modified="2019-04-10" version="1">MSFRNSSKPNPYNQDLNEGLVYDSKCLDKDATSLALPASLQAQFKSDSANEYDDSQLDNYWALQGKTLKGLTPGSESKAFTLEEELGEGGDWVLCPSKSEVPDADYAPNLRTRRPPNPKKLAKATARSKRVKRKNNKEPDVLIIIDLHMDIGPIMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZC18</accession>
    <name>A0A3S0ZC18_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome-binding factor A, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_016807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000743">
        <property type="protein sequence ID" value="RUS75428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZC18"/>
    <dbReference type="STRING" id="188477.A0A3S0ZC18"/>
    <dbReference type="OrthoDB" id="418445at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000238">
        <property type="entry name" value="RbfA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023799">
        <property type="entry name" value="RbfA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039212">
        <property type="entry name" value="RBFA_mitochondrial"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14725">
        <property type="entry name" value="RIBOSOME-BINDING FACTOR A, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14725:SF0">
        <property type="entry name" value="RIBOSOME-BINDING FACTOR A, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02033">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89919">
        <property type="entry name" value="Ribosome-binding factor A, RbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS75428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="395" mass="45135" checksum="7247571856E4A566" modified="2019-04-10" version="1">MIGVCRQQLKHCLQLQSGYHFTLALNGISRQNSGGIESSKHMLKLLTKKGAKTKRKWYQPHVAEPQELSGRKQQPNKYGVTEAQGHRARQLSHVLYAKICQIANSGELDEEILNKQVLFTKVKMHPTFSGINVYWDAKRSDAAEIETLLDGLSGKLRSLLISYHVLGRIPTITFVKDRSRGDLAQLNQLFEIADYGPDYVPSTEMDKDKSHIMMLNSPQNTTESPGHPTKNNLHENLSALALSFEQPGDIHESEKSRGDRLKTLSSEAGWESECEPPTGVGLKDTPDELVSGFRANLYGLPRDDLMKKIMIKKKKVRFQTSSTEDSRDTSISDLQLRDYRKLRSRVVKDKEKMLQQRDSTKIKQRLLERGFDEEQDFLHEDFTDDERNNNDRETH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZIU6</accession>
    <name>A0A3S0ZIU6_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_013465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000490">
        <property type="protein sequence ID" value="RUS78781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZIU6"/>
    <dbReference type="OrthoDB" id="6156642at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="445"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS78781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="481" mass="52255" checksum="DDA48DBA3F8DD56D" modified="2019-04-10" version="1" fragment="single">DLNETAAQKPWLEETTPGSGLFTFSFAGLANFKSKVMEMVAQKNKYLAERALLRQQMAEALFNRSVPYFQTMQSNFTDGGVDIEPFSVIQRIFGLGTDKPIDDDNVNEGKENGVIKQKDSNANSDNEDSAAAVTEISGDAIIDSALTLNQAEREEADKAVSPAISPIQTGKSTRFSEVTETTTKYPWGRWKAVHKNMWWNSDAAKKRQDFIQAKIQKSIEKRQMWERFASERFSGQEAHATPWGGVQSPPVGDGSEAHNIQDQGGILEDIKEKLRDQFESAITKLNESRNAFLKAKEDMAQGAAGKPWEKPALGGGTTFDPAALMSFKAKIHEMVTLKNQYVAERAALKQEMLTTLRDLLLEHLAQLTESEESPGSQELATPEGTPDTDLNAILQELIDTDTDAVDADVTEGLPFAQSLMLAAAPQGPPSGSDHVTGESGGSGSFAALITMGVVAVVATVVVVGGIMLKKAGRRSLYSHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZLI5</accession>
    <name>A0A3S0ZLI5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_011685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000385">
        <property type="protein sequence ID" value="RUS80545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZLI5"/>
    <dbReference type="STRING" id="188477.A0A3S0ZLI5"/>
    <dbReference type="OrthoDB" id="10059338at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480:SF5">
        <property type="entry name" value="SI:DKEY-51D8.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS80545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="743" mass="84720" checksum="E5895A626D5FE302" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZM11</accession>
    <name>A0A3S0ZM11_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">RecQ-like DNA helicase BLM</fullName>
            <ecNumber evidence="17">5.6.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">DNA 3'-5' helicase BLM</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">EGW08_011344</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">EC2010</strain>
            <tissue evidence="25">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="17"/>
    <dbReference type="EMBL" id="RQTK01000368">
        <property type="protein sequence ID" value="RUS80873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S0ZM11"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000537">
        <property type="entry name" value="Bloom syndrome RecQ-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000340">
        <property type="entry name" value="Bloom syndrome, RecQ helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000495">
        <property type="entry name" value="RecQ family helicase MusN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="23">
        <location>
            <begin position="613"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="24">
        <location>
            <begin position="814"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="22">
        <location>
            <begin position="1145"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="20"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="141"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="532"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1251"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1314"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1348"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="1263"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="25">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00073450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="RUS80873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1368" mass="153474" checksum="C6D60FB506E65E6A" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZNL6</accession>
    <name>A0A3S0ZNL6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tryptophan 5-hydroxylase 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tryptophan 5-monooxygenase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EGW08_020616</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">EC2010</strain>
            <tissue evidence="15">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with DNAJC12.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001186">
        <property type="protein sequence ID" value="RUS71624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZNL6"/>
    <dbReference type="STRING" id="188477.A0A3S0ZNL6"/>
    <dbReference type="OrthoDB" id="983542at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004510">
        <property type="term" value="F:tryptophan 5-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009072">
        <property type="term" value="P:aromatic amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046189">
        <property type="term" value="P:phenol-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04929">
        <property type="entry name" value="ACT_TPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.800.10:FF:000004">
        <property type="entry name" value="Tyrosine 3-monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.800.10">
        <property type="entry name" value="Aromatic amino acid hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001273">
        <property type="entry name" value="ArAA_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018301">
        <property type="entry name" value="ArAA_hydroxylase_Fe/CU_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036951">
        <property type="entry name" value="ArAA_hydroxylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036329">
        <property type="entry name" value="Aro-AA_hydroxylase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019774">
        <property type="entry name" value="Aromatic-AA_hydroxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019773">
        <property type="entry name" value="Tyrosine_3-monooxygenase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473">
        <property type="entry name" value="AROMATIC AMINO ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473:SF16">
        <property type="entry name" value="TRYPTOPHAN 5-HYDROXYLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00351">
        <property type="entry name" value="Biopterin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000336">
        <property type="entry name" value="TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00372">
        <property type="entry name" value="FYWHYDRXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56534">
        <property type="entry name" value="Aromatic aminoacid monoxygenases, catalytic and oligomerization domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00367">
        <property type="entry name" value="BH4_AAA_HYDROXYL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51410">
        <property type="entry name" value="BH4_AAA_HYDROXYL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0408">Iron</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="14">
        <location>
            <begin position="89"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Biopterin-dependent aromatic amino acid hydroxylase family profile" evidence="13">
        <location>
            <begin position="168"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000336-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601273-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601273-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RUS71624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="523" mass="59364" checksum="B9C020FDD9D1FAEA" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZNM9</accession>
    <name>A0A3S0ZNM9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_013111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000469">
        <property type="protein sequence ID" value="RUS79133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZNM9"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS79133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="158" mass="17108" checksum="7E16F1EB6FE311C0" modified="2019-04-10" version="1">MGLTMPSTGTTLYLVGSLCLGDVALGHEGHHEDGNNQRQATILALAICVGILGAMLIAITLAYFCKRRRVCFRCETSGADQDSQTTKSSAMSVGIMKSLFFSNDRQTVSEFTTLEEAVEKVPSTKELQEVQAEPETVAVTQPTHQEVLVTDVVELTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZQZ7</accession>
    <name>A0A3S0ZQZ7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_019000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000961">
        <property type="protein sequence ID" value="RUS73241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZQZ7"/>
    <dbReference type="OrthoDB" id="10425043at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS73241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="99" mass="11105" checksum="E206AA632B38C123" modified="2019-04-10" version="1">MKKQQSYLEGTHERVIHRHHATCIVKLSTVIGCRKQRDQLALGEKLITIFNNLQTETKSQIQNSILVMSVEELADHVCSKCEGHAPIILPPAHDILVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZTK8</accession>
    <name>A0A3S0ZTK8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_006723</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000167">
        <property type="protein sequence ID" value="RUS85515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZTK8"/>
    <dbReference type="OrthoDB" id="6132562at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018586018" description="EF-hand domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="16"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="91"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS85515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="145" mass="17353" checksum="0956315F0AEFD6A5" modified="2019-04-10" version="1">MLAPCIILLLVLQAQANPNYFQQRFAQTDRNRDNKISLKEYMDSLQFYDRNNDGRTTLSEWVSQMTRKANIPIDVSSLIFYVLDSDGNYLLNYVDKREVFKVMDFNDDGFVSREEFNTYWEQMKISVYRQLHRTRRSPDQDEVQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZX07</accession>
    <name>A0A3S0ZX07_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CHCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_004168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000093">
        <property type="protein sequence ID" value="RUS88115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZX07"/>
    <dbReference type="STRING" id="188477.A0A3S0ZX07"/>
    <dbReference type="OrthoDB" id="1106148at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055304">
        <property type="entry name" value="CHCHD2/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523:SF2">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2/NUR77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS88115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="156" mass="15715" checksum="91B74632BFD7CCA0" modified="2019-04-10" version="1">MPRRGRSGGMSRPAPAPAAPRRMSPAPAPVPAHAPPAQPPAMAQPKQPGLFAQMATTAAGVAVGSAVGHTIGAALSGGGGGHAAPEVAQAAAPTTALPAQPAPVAPAPLTNYDPNANPCKFQLEQFLQCTQTQHDISLCSGFNEALKECKVRYGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZX55</accession>
    <name>A0A3S0ZX55_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_007013</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000177">
        <property type="protein sequence ID" value="RUS85252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZX55"/>
    <dbReference type="STRING" id="188477.A0A3S0ZX55"/>
    <dbReference type="OrthoDB" id="72033at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057478">
        <property type="entry name" value="DAAF9_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056414">
        <property type="entry name" value="DAAF9_CobW_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040342">
        <property type="entry name" value="DNAAF9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058844">
        <property type="entry name" value="PB_DAAF9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058843">
        <property type="entry name" value="PH_DAAF9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33664:SF1">
        <property type="entry name" value="DYNEIN AXONEMAL ASSEMBLY FACTOR 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33664">
        <property type="entry name" value="RCG26366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23319">
        <property type="entry name" value="CobW_C_DAAF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25204">
        <property type="entry name" value="DAAF9_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25203">
        <property type="entry name" value="PB_DAAF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26246">
        <property type="entry name" value="PH_DAAF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAAF9 pita-bread-like" evidence="2">
        <location>
            <begin position="2"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="DAAF9 PH" evidence="4">
        <location>
            <begin position="179"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="DAAF9" evidence="3">
        <location>
            <begin position="368"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="DAAF9 CobW C-like" evidence="1">
        <location>
            <begin position="584"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS85252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="781" mass="87397" checksum="70B7EE05FB9F6D4C" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZYA9</accession>
    <name>A0A3S0ZYA9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">polyribonucleotide nucleotidyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Polynucleotide phosphorylase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_002589</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyribonucleotide nucleotidyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.8" evidence="2"/>
    <dbReference type="EMBL" id="RQTK01000050">
        <property type="protein sequence ID" value="RUS89668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZYA9"/>
    <dbReference type="STRING" id="188477.A0A3S0ZYA9"/>
    <dbReference type="OrthoDB" id="437922at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004654">
        <property type="term" value="F:polyribonucleotide nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000958">
        <property type="term" value="P:mitochondrial mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000965">
        <property type="term" value="P:mitochondrial RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09033">
        <property type="entry name" value="KH-I_PNPT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11363">
        <property type="entry name" value="RNase_PH_PNPase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11364">
        <property type="entry name" value="RNase_PH_PNPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000001">
        <property type="entry name" value="Polyribonucleotide nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000001">
        <property type="entry name" value="Polyribonucleotide nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000113">
        <property type="entry name" value="polyribonucleotide nucleotidyltransferase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000006">
        <property type="entry name" value="polyribonucleotide nucleotidyltransferase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012162">
        <property type="entry name" value="PNPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015848">
        <property type="entry name" value="PNPase_PH_RNA-bd_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036456">
        <property type="entry name" value="PNPase_PH_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03591">
        <property type="entry name" value="polynuc_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008805">
        <property type="entry name" value="PRK11824.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11252">
        <property type="entry name" value="POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11252:SF0">
        <property type="entry name" value="POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03726">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005499">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46915">
        <property type="entry name" value="Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S1 motif" evidence="9">
        <location>
            <begin position="674"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS89668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="761" mass="83148" checksum="09BC0514C6446878" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0ZZZ5</accession>
    <name>A0A3S0ZZZ5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transforming acidic coiled-coil-containing protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_005057</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TACC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000117">
        <property type="protein sequence ID" value="RUS87217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0ZZZ5"/>
    <dbReference type="OrthoDB" id="10255048at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007707">
        <property type="entry name" value="TACC_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05010">
        <property type="entry name" value="TACC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transforming acidic coiled-coil-containing protein C-terminal" evidence="8">
        <location>
            <begin position="548"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="507"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="642"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS87217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="720" mass="81320" checksum="D70ECB5D18CBD23F" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1A6M3</accession>
    <name>A0A3S1A6M3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Globin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Myoglobin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_000312</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the globin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000004">
        <property type="protein sequence ID" value="RUS91910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1A6M3"/>
    <dbReference type="OrthoDB" id="10417287at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="8" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="9">
        <location>
            <begin position="122"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS91910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="276" mass="31564" checksum="DBD7F794A9925254" modified="2019-04-10" version="1">MGCFMCTRLCDRGVASKGSFDSLDSDDHGFRALTNTCQEGLYHVEDIKAPEKSEFDVPKFSSSAMVYMNNSRQRPDLNPFAHGVEKNPEVYFRYFPFLKVKESGGVYILETEISQETVKSKDSIDKIQKTDEFLKHLKITNKIINCLVGIAITDDLEMVEPHLIRIGAKHAELGIPAKHMHAFQESFLDYLQELIELDKITYEKWNLFIKYIINTIIHGMNEHYNKVLFVYWSVHRNHGIKCFSANCGGRPKVRGIDGDCMLSLRNMAATVEALQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1ARJ9</accession>
    <name>A0A3S1ARJ9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit delta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_022157</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001496">
        <property type="protein sequence ID" value="RUS70082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1ARJ9"/>
    <dbReference type="STRING" id="188477.A0A3S1ARJ9"/>
    <dbReference type="OrthoDB" id="10254737at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233:SF14">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="462"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="94"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS70082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="545" mass="58745" checksum="9B9C21A4AF9C8822" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1ARZ5</accession>
    <name>A0A3S1ARZ5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hcy-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_021824</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001414">
        <property type="protein sequence ID" value="RUS70416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1ARZ5"/>
    <dbReference type="STRING" id="188477.A0A3S1ARZ5"/>
    <dbReference type="OrthoDB" id="261426at2759"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00083"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008898">
        <property type="term" value="F:S-adenosylmethionine-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033528">
        <property type="term" value="P:S-methylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017226">
        <property type="entry name" value="BHMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051486">
        <property type="entry name" value="Hcy_S-methyltransferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007020">
        <property type="entry name" value="PRK09485.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015:SF1">
        <property type="entry name" value="HOMOCYSTEINE S-METHYLTRANSFERASE-LIKE ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015">
        <property type="entry name" value="ZGC:172121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037505">
        <property type="entry name" value="Betaine_HMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="7">
        <location>
            <begin position="1"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS70416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="317" mass="34671" checksum="EA4ABE8BD5529202" modified="2019-04-10" version="1">MTSALIRSSKNVVVLDGGTGTSLANLGHSVEDLTWCSGLIETHPHHVKQVHKDFFIAGADVVCTSTYQAFVDGFVKQFGVSEQEALDLIKRGVKLAKEARDEAELETGRHGFVAASVGAYGATLCDKSEYSGVYVDKLSREELYEWHLPRMRVLCAAGPDILACETIPAVEEALALVRCLETLKTHAWITFSLRDAKSTCHGEDIRVALAAVVSSPYVVAVGANCFSLTLVDDFLRYVKDLPLFDKPLIIKPNAEKSEHDRSLSEQKLHERVLDWVDAGASWIGGCCKTDSTDIASVRDQLAKASHICFKKNGEALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1ASP7</accession>
    <name>A0A3S1ASP7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_021215</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001284">
        <property type="protein sequence ID" value="RUS71028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1ASP7"/>
    <dbReference type="STRING" id="188477.A0A3S1ASP7"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000009">
        <property type="entry name" value="Visinin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF178">
        <property type="entry name" value="NEUROCALCIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="60"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="144"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS71028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="191" mass="21979" checksum="4EA8B1D0DC84F363" modified="2019-04-10" version="1">MGKANSKLKPEVMEDLLEQTQFTEKELQDWYKEFLKDCPSGKLNVDEFKMIYANFFPNGDPSTFAELVFRTFDKDGNNTIEFREFICGLSVTSRAPLDRKLRWAFTVYDVDGNGFVSREEMVHIVRAIHKMVGDAVRLPNDEWTPEKRVEKIFSQLDTDLDGKLSIQEFIRGAKKDPALARLLQCDASVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1AVZ7</accession>
    <name>A0A3S1AVZ7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_022474</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001582">
        <property type="protein sequence ID" value="RUS69768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1AVZ7"/>
    <dbReference type="STRING" id="188477.A0A3S1AVZ7"/>
    <dbReference type="OrthoDB" id="6354171at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055303">
        <property type="entry name" value="ATMIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46664">
        <property type="entry name" value="ATM INTERACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46664:SF1">
        <property type="entry name" value="ATM INTERACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS69768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="96" mass="11394" checksum="719E6CC4C2693DF0" modified="2019-04-10" version="1" fragment="single">KDVIKQYHCPVTSCYYNNSSERFFKNMDILRVHYMKVHSEKNFKCVKCDKGFGLARDCQRHEEECGQTFPCPQCGKVYTKKDSLLRHCDVQKHCRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B000</accession>
    <name>A0A3S1B000_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_019486</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001023">
        <property type="protein sequence ID" value="RUS72751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B000"/>
    <dbReference type="OrthoDB" id="6150053at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018780672" description="Ig-like domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="257"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS72751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="389" mass="42742" checksum="B21635B885B2B30C" modified="2019-04-10" version="1">MALCTLQFLLLFIFIQGAKAQTITLLKFEPSFKCSNDFLVENEDYIFFEYEFTGGSSTYGHDAFTGPKIYHTIASSTVLHNPCNVFEVVNPICQDKLGVPFQCSCFELTAGSHYRTEFNMTALVDFSRESVWLQWPGPPPINSENTTLPEIRDACPATGKDRDFDKWVVPVLFCVNVAVLISVVIFLKFCAEMGSTIKMALPIIFALAFLIAFVIILAVCSDFLENWETGLAIVAIILDGIHVLMIIIFVKGYRVLPCYQAHTATKTHSVENGKELSADQVEGVMGGEVSLPCQLDSNLTPSAVTWSKGGKQLDLTSTAKYGEGTVKEPSLRIFGLDKSDAGSYTYSVSFGKGKEESRKINLRVTDKQTNAQDGDGNDGDGAPSKNHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B0A7</accession>
    <name>A0A3S1B0A7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EGW08_023511</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">EC2010</strain>
            <tissue evidence="5">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01002058">
        <property type="protein sequence ID" value="RUS68726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B0A7"/>
    <dbReference type="STRING" id="188477.A0A3S1B0A7"/>
    <dbReference type="OrthoDB" id="79941at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038">
        <property type="entry name" value="RIBONUCLEOPROTEIN RB97D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038:SF1">
        <property type="entry name" value="RIBONUCLEOPROTEIN RB97D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="4"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RUS68726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="104" mass="11554" checksum="B79B4A4F64F84E7D" modified="2019-04-10" version="1" fragment="single">MVGTKLFIGNLPDTVDKDELEGMFNKFGKVVEFDILKDYGFVHYENESEAKAAVEALDGQVHRGSNIRVEVSRSRVRQKAGMGGKGECYRCGGEGHWSKECPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B3B9</accession>
    <name>A0A3S1B3B9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein 180</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_017149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000772">
        <property type="protein sequence ID" value="RUS75095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B3B9"/>
    <dbReference type="STRING" id="188477.A0A3S1B3B9"/>
    <dbReference type="OrthoDB" id="62987at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040035">
        <property type="entry name" value="TMEM180"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28658">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28658:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13347">
        <property type="entry name" value="MFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS75095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="55252" checksum="3FEE7207A297F1F4" modified="2019-04-10" version="1" fragment="single">KMAAPTVSLETAYGSVTLFTSILHNVFLLYHVDMFVSVYQISKTAFWCGEALFLVWNSLNDPLFGWFSDRNLLEYSADESKHSKDIVWTRLRALQIYCPLFTLSFCLFWIGWAFPGVQFAICLCLYDGFLTMIDLHHSALLADLSVSAVVRARLNSKCSIFSAIGSASVFLSYLVWNKADLKAFRMFCGCLALFSFLGYIVMVRSLKKAYMKKTEDATSVERTWEKNGERADHTLQTVSVAKFGCQLLSHKNFMWFSMLNLLQVFHCHFNSNFFPLFLDALLGESVSPTLSSLLLGVSFVVPHLNNLYFLTLTSRYGVYSVIQALLLVKLILSLLMWQIGPTAIWLLCIFIASNRVFTEGTCKLLSLVISDLVDEDAVLHCRPNAVSALIFGTAALLSKPGQTFAPVIGTWVLSLQTGHDIFRSGLESGSIKADLSLMDSNAREAHRSGVFFILVCVPVVCALLQLLVWSQFSLKGHRLAQVKAAREGLNHIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B3D2</accession>
    <name>A0A3S1B3D2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LRRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_021254</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001291">
        <property type="protein sequence ID" value="RUS70989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B3D2"/>
    <dbReference type="STRING" id="188477.A0A3S1B3D2"/>
    <dbReference type="OrthoDB" id="6156721at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000770">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF370">
        <property type="entry name" value="FISH-LIPS, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018664083" description="LRRCT domain-containing protein" evidence="7">
        <location>
            <begin position="23"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="957"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="32"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="640"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1042"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="657"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="686"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="700"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="721"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="834"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1067"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1092"/>
            <end position="1104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS70989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1125" mass="118913" checksum="18D1625BFB11CDFB" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B5K8</accession>
    <name>A0A3S1B5K8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_011826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000392">
        <property type="protein sequence ID" value="RUS80414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B5K8"/>
    <dbReference type="OrthoDB" id="6152605at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS80414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="403" mass="43268" checksum="5CF43C3E74D765E4" modified="2019-04-10" version="1" fragment="single">MASEPGISFIENFDTNCLGLDVSMDNNDLFMTDGIMNPKELYLTEEESGLVKDAASSSDSGISTFDDLQDIANVTDLNSLMDGDLRDLDFGIEFALHTADHDVFDPAVLVKEEPLSPASDGSTCQSTDSALDFSCLQQPVSPQFCNFHNEITIKEECGVDFSSHDQIFVHRQQQHSSPYSHADVISHQPLQQQQQQQQFDSLYNGASHFSASSPTSYVLSPSTHHSEATMEAALSSPSSSTSSSSSYEPLMSLVHASHKQQQQQQQQHNNVAFKMSPNSSPSPGQPHGYVVVPTSPQQSQSSGSGSVSGPVRKIVLGTKRLSVLPAQSLRQPVRQLSSGSERDLAGLSQSQCVSPTSLSSSLSSPSSSSMSMTALASSCASYQIDAILNSNIRIQPKPGADVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1B7Y1</accession>
    <name>A0A3S1B7Y1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RCC1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_015034</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000600">
        <property type="protein sequence ID" value="RUS77207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1B7Y1"/>
    <dbReference type="STRING" id="188477.A0A3S1B7Y1"/>
    <dbReference type="OrthoDB" id="70707at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070131">
        <property type="term" value="P:positive regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053035">
        <property type="entry name" value="Mitochondrial_GEF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46337">
        <property type="entry name" value="RCC1-LIKE G EXCHANGING FACTOR-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46337:SF1">
        <property type="entry name" value="RCC1-LIKE G EXCHANGING FACTOR-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="72"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="3">
        <location>
            <begin position="74"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="141"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="207"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="263"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="316"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="369"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="427"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS77207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="478" mass="51649" checksum="A6B74871AE863B08" modified="2019-04-10" version="1">MIKLRHLATLAIDACKQCGSVHASRPAVTVLSQSRSFFTGTCLTNWKKKHAKREAKKAEVHKYVGDNADRTTIVYAWGAADSGALGIPSYLRPNLKNLQRQFLITMINRPARVRFYDKQKMKALKVACGHGFTITSVKFQNKKFLLGCGINTDSQIGFHEAPKGSGRIMDQLIEPGRIRLPLQRPDHCSVVSMACGRAHSVVVVEDEGVFTLGNNAFGQCGRSIVEGEDYSKNPTINRVRELPDDVIKVVCGQDHTLFLTESGQVYSCGLGADGQTGSGHYKPVGHPVLVAGDIQGETIVSIGARADCSLAVSDKGDVFGWGNSEYGQLGLVTDLTQVNMAAHLPTSRCGRVVKAVAGGSLCALLNDAGQVFVWGFGILGKGPKLESTAEPSLIPEPIFGRNELNPDTRVVDIDCGLTYVAAINDQGDLYTWGKNSRGCLGLGEEKNQFFPWRVALPAQTVEFSCGSDHMAAICKSYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BGE1</accession>
    <name>A0A3S1BGE1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">Ionotropic glutamate receptor C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">EGW08_012031</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">EC2010</strain>
            <tissue evidence="24">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Postsynaptic cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000405">
        <property type="protein sequence ID" value="RUS80206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S1BGE1"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043226">
        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000078">
        <property type="entry name" value="glutamate receptor ionotropic, NMDA 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="539"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="578"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="610"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="788"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="22">
        <location>
            <begin position="420"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="23">
        <location>
            <begin position="420"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="245"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1010"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1107"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1148"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="1387"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="1037"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1156"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="500"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="699"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with the cone snail toxin Con-ikot-ikot" evidence="17">
        <location>
            <position position="469"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="714"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="RUS80206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="26">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1417" mass="158374" checksum="21A86CC59373E2A3" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BH61</accession>
    <name>A0A3S1BH61_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphatidylinositol-glycan biosynthesis class W protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_004051</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000090">
        <property type="protein sequence ID" value="RUS88219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BH61"/>
    <dbReference type="STRING" id="188477.A0A3S1BH61"/>
    <dbReference type="OrthoDB" id="15270at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032216">
        <property type="term" value="F:glucosaminyl-phosphatidylinositol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009447">
        <property type="entry name" value="PIGW/GWT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06423">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS88219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="35940" checksum="7214AF69ED1A43BD" modified="2019-04-10" version="1">MSDFKHEHEAFLAGHNGTSFLEIGALTSIPCIGCFSREIILIFMLDLDGISKRRRFLLDFLTLVMPSAIAATLMSNHIVYICAFLLAVSLLAYWIGLKRNVMDLHSLHMANLSEQKLCIVWYRSIVNLMTAIAILAVDFPIFPRRLAKSETYGFGGMDNGVGFFVIANAIVSPEARGKHCQIPVFIQLKHSFKGCIPIMLLGFVRLIAVKGTDYHEHVTEYGVHWNFFFTLAALRLMSTLLYCLICVDQSMLIGLAITVLQQLLLSLCGLSNYIINGSEGTGSRVGIFDANREGILSIPGYLAIYLFGVAIGQFFFEKRFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BLD2</accession>
    <name>A0A3S1BLD2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mos1 transposase HTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_008752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000241">
        <property type="protein sequence ID" value="RUS83502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BLD2"/>
    <dbReference type="STRING" id="188477.A0A3S1BLD2"/>
    <dbReference type="OrthoDB" id="6154603at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041426">
        <property type="entry name" value="Mos1_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF1">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17906">
        <property type="entry name" value="HTH_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mos1 transposase HTH" evidence="1">
        <location>
            <begin position="6"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS83502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="193" mass="22584" checksum="914B2B0786257E80" modified="2019-04-10" version="1">MEAVEYRSVIKFLHLKEQTPTEIHQQMVEVYAEKCPNYSTVTHWVRKFKSGFLSVMDEPREGRPTSVVTEKNVSTVEGLVKQDRRITVKQLASETRISVGSVEKILHDHLNLNKVSARWVPRLLTADQKKERADCCKHLLRLEANDDLFLREREEREERDRGRERVSVQYHEIGEVLVSRSKIQALHSLLREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BLL7</accession>
    <name>A0A3S1BLL7_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_008533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000234">
        <property type="protein sequence ID" value="RUS83685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BLL7"/>
    <dbReference type="OrthoDB" id="6207654at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="116"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS83685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="150" mass="16656" checksum="A2CAC3CAAEA885EB" modified="2019-04-10" version="1">MAIYKTDPDRPGTQRDSRKPFLVASVNSQQPILSRVANAIKVDGRLENYTTSIRLELFKQEDCRAEFTCQLVAVDAQGRELVRTSHLLQQPSSSASHSAGGQGWTPAVVMHLVDLAQDLNTNMQLMRSAMDDFRNRLSGVEDKVAALRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BLW9</accession>
    <name>A0A3S1BLW9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SMB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_022097</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001481">
        <property type="protein sequence ID" value="RUS70144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BLW9"/>
    <dbReference type="OrthoDB" id="6216652at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036024">
        <property type="entry name" value="Somatomedin_B-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001212">
        <property type="entry name" value="Somatomedin_B_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90188">
        <property type="entry name" value="Somatomedin B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50958">
        <property type="entry name" value="SMB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMB" evidence="3">
        <location>
            <begin position="151"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS70144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="767" mass="84989" checksum="BBAE0568D4AA0BAD" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BSU3</accession>
    <name>A0A3S1BSU3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_004234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000095">
        <property type="protein sequence ID" value="RUS87956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BSU3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS87956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="259" mass="29255" checksum="BB693400BBF883A8" modified="2019-04-10" version="1">MTLLVHDRIEQGEVSFNASFKNMSRKNFIPGALYIRPSEVLKARSAADLFPMRYQSQMTAAVALIVALDVHLPLDFYLMGGDYSVGEDAARTDWDIFYRAYEIFTTGRKEFRSRRRFSKRQSRNSVDEIDTVWHIITSKSWAEASGFLQAKLIGDSYYELDRIVHDQKLIVEGEQRDDLVAELDRLLYRCDRSGRYPGVPFSQVCDGVSGADEALCGETGYPRCHPTSFSSPRTSACRWRRGVTSFGTAGTRATAQTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BU48</accession>
    <name>A0A3S1BU48_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_000629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000008">
        <property type="protein sequence ID" value="RUS91656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BU48"/>
    <dbReference type="OrthoDB" id="6161508at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS91656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="442" mass="47027" checksum="7BE7CCC9F749637B" modified="2019-04-10" version="1">MDQVSEQSCNVSSRSKGFPFSILGAGGTHSTSFFHIGEQHPHSVVDSSSLIHRTHAFSYSPQTRKTLPPPPPAPAPAAPSQVAGDGEKTIRMTLVTADGQTPRRGRRRSSLFDSNVEPPKQMQVSVLSVASQGSRSFSKEREVRVSDHRSSRRYSAAQGSLEDMSQDTASFLHNTYTSALSHHDEEVQFSSKESSALNVYADSPSLPATAGVSAPVPIHGAIHRNPDAFYTSSDDLKPLSSISTIAQALPSVQNATESMGNARQTLPLVPNNDLDIESPALPQHSFENQSIGMSRSPGKVLSAIASNPAVLSSINSGLKNADGNTNQNLSVPARNHDLAQNSSKDNANLLEIVQQDKAVAPKSRQSGTPVIFRSSHIADVRPAERSAGIDAGPGLDTHRSGRGGDGLFSWVRKIGAWMGATGDTDQVDVSKKDLNVIAPSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BUP3</accession>
    <name>A0A3S1BUP3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_016907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000752">
        <property type="protein sequence ID" value="RUS75318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BUP3"/>
    <dbReference type="STRING" id="188477.A0A3S1BUP3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS75318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="116" mass="10230" checksum="1B69828F187A9934" modified="2019-04-10" version="1" fragment="single">IQRACFGPGPGGPAGLLGPRPEGPAGPGGPGGTLGPESCGPVGTLGPASWGPVGTLGPASWGPVGTLGPASWGPGGPAGPGGTLGPASCGPSGTLGPASWGPGGPCGAGGPLGPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BUZ1</accession>
    <name>A0A3S1BUZ1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_002836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000057">
        <property type="protein sequence ID" value="RUS89399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1BUZ1"/>
    <dbReference type="OrthoDB" id="10587180at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS89399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="183" mass="20676" checksum="84AE216FA90120D1" modified="2019-04-10" version="1" fragment="single">METTPIARRKDSVTSFRKRSSVPALRKGSYVAFQPVTRNTGLRRHSCREVLGLTSRQLSSPLSFDLQTDEPDATTWSVLMSSIPAADRRMSQIRRQHLVISVPVCVVGKENPVTLTSMEAIERTLRRHHPEIVVKKKASPDEDLSSTTRTDNKIDLMSPPTTPGQSPTRDRKKAVVSEYRHHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1BYN6</accession>
    <name>A0A3S1BYN6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fatty acid synthase</fullName>
            <ecNumber evidence="1">2.3.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_013895</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H(+) = a long-chain fatty acid + (n+1) CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.85"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.85" evidence="1"/>
    <dbReference type="EMBL" id="RQTK01000516">
        <property type="protein sequence ID" value="RUS78344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A3S1BYN6"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000047">
        <property type="entry name" value="NADP-dependent L-serine/L-allo-threonine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF6">
        <property type="entry name" value="BETA-ALANINE-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="551"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS78344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1308" mass="145306" checksum="81D712C8FD71600C" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HJ83</accession>
    <name>A0A3S1HJ83_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA mismatch repair proteins mutS family domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EGW08_011718</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">EC2010</strain>
            <tissue evidence="9">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000386">
        <property type="protein sequence ID" value="RUS80534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HJ83"/>
    <dbReference type="STRING" id="188477.A0A3S1HJ83"/>
    <dbReference type="OrthoDB" id="276261at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.110:FF:000003">
        <property type="entry name" value="mutS protein homolog 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000870">
        <property type="entry name" value="MutS protein homolog 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF21">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein MutS core" evidence="7">
        <location>
            <begin position="276"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="8">
        <location>
            <begin position="610"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="16"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RUS80534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="877" mass="98544" checksum="62B2BE4AC57FC752" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HQU1</accession>
    <name>A0A3S1HQU1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_007924</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000209">
        <property type="protein sequence ID" value="RUS84330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HQU1"/>
    <dbReference type="OrthoDB" id="6160426at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="337"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS84330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="414" mass="44368" checksum="45F8D08A72BD3A71" modified="2019-04-10" version="1">MDVLWSGGDGWIPPDFVEHSRLHKWTMSSKRKNTPTKLPKEDIDEQEEDHIHTDFALDHVTSDRGAFQVDGWGNSGYHSNATNTNSGDCFSLPNAPSASIAGTSADAPNRVLSQSQNGGDPERNNSAEKLSFSERQTNGCINNSFEDAGETTETQTENKPSKSFGLISGETLELDEPQLEAGTCLSGTGTSGSSPGTNSPLSASSVLPQQKRSMESVIRRLNSKASDSFGVGGGFSSVSEISVGDDPVTSTGESMTLTPAGGSDLDPATLTPGEENPPVMDTVQAVLAGEATLSEKERQISEMIHHLQNIKENLSKQKPTCQSPTAGSAKTRQVITLILFGIPGKFLAVVALAYLASSAFAASRRRRSGHSRRAWGLQMWIPGLGAPLGWRYPDTRSRLPTRQAAKEEKPRQNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HRC4</accession>
    <name>A0A3S1HRC4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_007597</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000199">
        <property type="protein sequence ID" value="RUS84625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HRC4"/>
    <dbReference type="STRING" id="188477.A0A3S1HRC4"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01450">
        <property type="entry name" value="vWFA_subfamily_ECM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF20">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018557650" description="VWFA domain-containing protein" evidence="1">
        <location>
            <begin position="31"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="198"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="506"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS84625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="637" mass="68282" checksum="C636B33D8BE599FD" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S1HVB9</accession>
    <name>A0A3S1HVB9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_005462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000128">
        <property type="protein sequence ID" value="RUS86802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S1HVB9"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS86802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="140" mass="15779" checksum="037847746E8C8D55" modified="2019-04-10" version="1">MRAPCRYSAAPHPHRGSGNSAPARPPTTPAPRNGIRTSPITFTSPTFPSTLIRTAVRRTFITLARTCPHPSRSIGTRLRRTSYFSTGANPHWRLDTNTRSGLRLSPSERTRAPTQKRRTTWSLHAPLKTLRMRTPTRTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SI86</accession>
    <name>A0A433SI86_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_023819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01003267">
        <property type="protein sequence ID" value="RUS68420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SI86"/>
    <dbReference type="STRING" id="188477.A0A433SI86"/>
    <dbReference type="OrthoDB" id="1914839at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048264">
        <property type="term" value="P:determination of ventral identity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28654">
        <property type="entry name" value="AXIN INTERACTOR, DORSALIZATION-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28654:SF1">
        <property type="entry name" value="AXIN INTERACTOR, DORSALIZATION-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS68420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="135" mass="15202" checksum="590848378227B2E2" modified="2019-05-08" version="1" fragment="single">ERKKEVKENSKENGLNEKAGDTKTPQPHSIEKLLDKAEQFIDEFKYELAQKFCQRALELEPDNVRALETSASLLLELGDVESAKHCLGRAVQVSPENGFSKYMTLGQLMEGATAVQCYQKGVELMLAEKEKRQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SLE8</accession>
    <name>A0A433SLE8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_022269</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001524">
        <property type="protein sequence ID" value="RUS69973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SLE8"/>
    <dbReference type="STRING" id="188477.A0A433SLE8"/>
    <dbReference type="OrthoDB" id="6278242at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000634">
        <property type="entry name" value="Zinc finger X-chromosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS69973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="194" mass="23290" checksum="015520D936892094" modified="2019-05-08" version="1" fragment="single">YSCPICMVMYDSPEDLQRHMKHHDETKPYKCDVCGRGFRTKYMMQKHASVHQEEVSCRCEICGVAFYNIKTLQYSHKSKILKRYNCEICNKAFSSNSDLKTHRRTHSGETPFKCDYCERSFKQRGHRKLHIQVVHTKEMPYKCDECDAAFPTRYRYQIHMKRHTGVRDYKCVICDKEFYTLGKLNDHMKRRHPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SPG2</accession>
    <name>A0A433SPG2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_021203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001283">
        <property type="protein sequence ID" value="RUS71032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SPG2"/>
    <dbReference type="STRING" id="188477.A0A433SPG2"/>
    <dbReference type="OrthoDB" id="6147016at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46114">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46114:SF1">
        <property type="entry name" value="ZAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS71032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="409" mass="47536" checksum="6E4D6F0A5754BF70" modified="2019-05-08" version="1">MTESQKVALVRKYLGCSVQDEFACYPAESGDSMVRESLIFLSDNIGHDHHAVQDFTHRSIDILRQKMSIKKLTIWRDGAASQYLYKKVHTRRQHRSHRAWRGCANHPWLRKYRQFQALGQYVLQARRLACFCSACRENKPAQCLNVDYYTVHKCKPSTITQLNQGFLEAPEAEDNSSTFSSATPSAVATKDRHWDQKEWPVRTSLTVGEKNVINEPLVDRARIVFPPLHIKLGLMKQFVKALDTDGECFKYLCEAFPGVTYEKLKAGIFDGPQIRKLIKDTSFVRSIKSAEKNAWESFVSVVREFLGNRRSENYKELVQNMLEKYCALGCNMSIKVHFLHSHLDRFPENLGDVSDEQGERFHQDLKVMEDRYQGRWDIHMMADYCWSIQRDCVGKKHSRKSLKRKFVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SQQ1</accession>
    <name>A0A433SQQ1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EXPERA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_020669</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001193">
        <property type="protein sequence ID" value="RUS71576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SQQ1"/>
    <dbReference type="OrthoDB" id="8181520at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059044">
        <property type="entry name" value="TM_Tm6sf1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14568:SF8">
        <property type="entry name" value="EXPERA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14568">
        <property type="entry name" value="TRANSMEMBRANE SUPERFAMILY 6 MEMBER 1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26083">
        <property type="entry name" value="TM_Tm6sf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="7">
        <location>
            <begin position="114"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS71576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="296" mass="33651" checksum="4E2FA7A89E6B3A00" modified="2019-05-08" version="1">MVTGIEPFMKTSFGVVSTYWNGIVHLILYLAAVTLYVRRDSHREVTLFWAGSFLNMYVVLLPALITQTPNDKSAIFINAPIIVIPVIAIGYYMHRRPVQARSFLEAPKIWKRPVDLLFFVYFLIAACVVVFRGMAVVGGKASCMKDYLNNCEPYLKDSHNFPKFQALSYLYFYLAYYLSAMYGLVYPGQHWMADWSLVHAGAAAQAQFTHIAGAFNRRTAANMRPPTAGTNGLIFWSINLIMLVIPQLFALWCLRDPENHGRTYTVDLATPNYLVGDIVKKPARIYHSKRETKKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SRF4</accession>
    <name>A0A433SRF4_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_020518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001170">
        <property type="protein sequence ID" value="RUS71721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SRF4"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS71721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="604" mass="80325" checksum="8B03E01BE7947BC3" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SU92</accession>
    <name>A0A433SU92_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_019491</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001024">
        <property type="protein sequence ID" value="RUS72741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SU92"/>
    <dbReference type="STRING" id="188477.A0A433SU92"/>
    <dbReference type="OrthoDB" id="6160520at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="72"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="105"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS72741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="236" mass="26397" checksum="A3E54CDF93F40222" modified="2019-05-08" version="1">MLARTKVDNSNKNWRSGCSCWTSAATEGEKRTGQEIPKEHLNVSLLEACRKGREFVVQKLVRSGIEVNVKGNCFTLLHVATERNFVDIADFLLDKEVDVGAIDHHGNTALILAVTRAGCSDMLNLLLACRANVDYQNSQKAIDLMRAIELWILAQTQTEPTGVGRRPFFLDMSEKDLGSVKQQVNTGANLEACNSEWWTPLLPAARCCHTQVVELLKDCGANMKWIKVVEMLYFNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SX22</accession>
    <name>A0A433SX22_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_018376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000893">
        <property type="protein sequence ID" value="RUS73854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SX22"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS73854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="101" mass="11683" checksum="F24580BDD8A783ED" modified="2019-05-08" version="1">MHQIFRDRNQICAHVLSVHHKHTNTQSSSSYSSTHTHTHTNTQSSSSYSSTHTQTPKALHLTAAHTHKHKHPKLFILQQHTHTNTLSLSHRFYRIKSYSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SY98</accession>
    <name>A0A433SY98_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_017985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000851">
        <property type="protein sequence ID" value="RUS74247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SY98"/>
    <dbReference type="STRING" id="188477.A0A433SY98"/>
    <dbReference type="OrthoDB" id="10011262at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF23">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS74247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="27196" checksum="440CF112D76B34E6" modified="2019-05-08" version="1">MTQSLHNTSTVSPLEDGLQPHLADLDYADLYPDADTIVDVWYWLVGVAGSLIGCLGIVCNILSLGVLTSKPMRTTSNLYLTALAAHDLLFVVASTMFVSMEYFHHGLTGQNDWYYSFVNPSLPFADAFMNTSVTGSVYTTILVSVDSLYLGFEPRSNRSFYTDSFPLQINTTAKAITTTITTTNINNITITTTVNTNKTTATNTTTTITTTTTTITTTNNTAATTTITTTKTPKLPPPPPPQTIKSSSFSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SYP7</accession>
    <name>A0A433SYP7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_017819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000832">
        <property type="protein sequence ID" value="RUS74425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SYP7"/>
    <dbReference type="STRING" id="188477.A0A433SYP7"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF68">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATG1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="67"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS74425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="200" mass="22951" checksum="4CF73230ABFE0EB4" modified="2019-05-08" version="1">MRHEFVTLLRDLEHEGSPAVTHTHPCELEDIWAYRFPLPLSRIKPKAIKTGNKYYDQILPDLPKIGYKPLQVIAKGQSGTIILAQDVREGTEIRETECQPVAIKLHSGKRRKQTKADDGQGRELADEILIHKRLQHQNIVSLLNTILYQGRTGLVLEFCESGNLESLLRVHDARFVSEAIARRYLRQLHSGVEYMHLSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433SZV5</accession>
    <name>A0A433SZV5_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_017393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000794">
        <property type="protein sequence ID" value="RUS74836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433SZV5"/>
    <dbReference type="OrthoDB" id="6210549at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS74836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="210" mass="23433" checksum="841A54EF8F5B49D2" modified="2019-05-08" version="1">MGPKEKPMHVHFLKRNISREGKVRRKQEAASGEVSGPCDLKQAVISYRIHCMGAGSGPPPDEPPYYGWILNIMGDRLVAEAIQVNIPDSWDDNTIIKQQNMSSMYGSLQENGNADMTGVPPTEDSDEAQSLSLTPSVSFGTAADQQRWSQPQPKMFNNRKRTAAKARFAFGNGNPQLCDELIKVQIEYYKVKTELVKEQLLKLRNNPPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T0L9</accession>
    <name>A0A433T0L9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_017133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000771">
        <property type="protein sequence ID" value="RUS75102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T0L9"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS75102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="201" mass="21847" checksum="D3613E14EC0B5F83" modified="2019-05-08" version="1">MRRPHFELEDEFRKEKPSGFSRFQPPPSKNFSRHSHIGRCAGQTVLGEIKADSLLGRPPWTPVRCATCDALATTKGTNIAEKTCQQTDLRPSIGMAGGRQLLDIGHEYPAAPRGALTALFGDFPSQIPVGARMVRTLLGQAETSSVRGEPAPPGVDAELVPQIVGPYRCCCSARSRVWSAFPPLATIVYGDRTITTLPQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T2N2</accession>
    <name>A0A433T2N2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_016440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000710">
        <property type="protein sequence ID" value="RUS75813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T2N2"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS75813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="172" mass="18693" checksum="33220E6D92625567" modified="2019-05-08" version="1" fragment="single">CITLTNVQFSCVRVCSTTLTSVQFSCVRVCITLSCTSTTLTSVQFSCVRVCITLSYTTLTSVQFSCVRVCITLSCTTLTNVQFSCVRVCITLSCTTLTNVQFSCVRVCITLSCTTVTSVQFSCVRVCITTLTIVQFSCVRVCSTLTVVQFSCVRVCSTTLTSVQFSCVRVCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T4B6</accession>
    <name>A0A433T4B6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_015850</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000667">
        <property type="protein sequence ID" value="RUS76370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T4B6"/>
    <dbReference type="STRING" id="188477.A0A433T4B6"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005335">
        <property type="term" value="F:serotonin:sodium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015842">
        <property type="term" value="P:aminergic neurotransmitter loading into synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF23">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS76370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="29846" checksum="91512ABC0864D419" modified="2019-05-08" version="1" fragment="single">MSSTDDSAINARSRMNPSRVPKISPKRHAKRIGYGATIGSRKQSHLTPPPTSNPKNYSFKDDDGGDGRRRGDGNDDESDIKTDAFWKLTSASSTCEAAGGSCCCGFPCCGCGENRRRPARRGCVVFIVFLALLLDSLLLTCMVPIIPNYLRESATKEDRPSPATPSITPATIIEPGLSVHKWGLDDSFQMSPVLPHNSVKSMSNNADVQQPLFKKPTTSPSMANMTYTKENTKISLLFASKTLVQVLTNLIVGPLTERIGYSVPMFSGFVVLLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T6B1</accession>
    <name>A0A433T6B1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_015129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000609">
        <property type="protein sequence ID" value="RUS77113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T6B1"/>
    <dbReference type="STRING" id="188477.A0A433T6B1"/>
    <dbReference type="OrthoDB" id="6142134at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS77113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="621" mass="68904" checksum="81B1688BCFEF3CCC" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T705</accession>
    <name>A0A433T705_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EGW08_015009</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">EC2010</strain>
            <tissue evidence="6">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000597">
        <property type="protein sequence ID" value="RUS77234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T705"/>
    <dbReference type="OrthoDB" id="422206at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF27">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 49 MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RUS77234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="26205" checksum="E80B58FC701F0E7C" modified="2019-05-08" version="1">MVYFPAKPPLPPTISASVKRLSHGEGIRSLLKNVQFHLILFIFGFGAGVYQGFSQVLDINLDTLGVSQTTAGWMGFYSIIGGCLLGCFMSWISDMFTRKLKLFLLLMVIPGTAALVWFLMLINEYIPTDMPSLYITVILPGCFIYGSQPLFYELACEAAYPTGEDVATFLLTTAQNLVAFLILAVMVVPGSSVSWINWVLMVSAALGLVLLLLVREDYNRLKVDDMEVQIPKPDGDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T746</accession>
    <name>A0A433T746_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_014826</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000583">
        <property type="protein sequence ID" value="RUS77407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T746"/>
    <dbReference type="STRING" id="188477.A0A433T746"/>
    <dbReference type="OrthoDB" id="10070415at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF25">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS77407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="14785" checksum="5AEE25103BB75273" modified="2019-05-08" version="1">MAFVIGLNFTAFKRFEIKDGKVLTRIMLERLKTALDKKLREEQAGFRQERSCTDQFATLRNIIEQSLEWQSPLYTVFVDFQKVETEIMKRKWGWIGHTLRKPASNITRQALDWNPQGKRKVGRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433T8I0</accession>
    <name>A0A433T8I0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_014330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000544">
        <property type="protein sequence ID" value="RUS77899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433T8I0"/>
    <dbReference type="OrthoDB" id="10252017at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043:SF8">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019024897" description="EGF-like domain-containing protein" evidence="2">
        <location>
            <begin position="48"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="60"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="116"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="153"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="194"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS77899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="229" mass="24466" checksum="D190F914EB488578" modified="2019-05-08" version="1" fragment="single">MFLRLSSNLVITGTLCSNRLIHWNYFLHNSMLAFVLLALTLCGTTHGCEEGLYGPDCDKTCSATCEFGRCHSSTGRCRSCPPGRDGSQCNRDCKTGMFGHGCDKYCSRYCWSGSEACDPVDGACVNGCKAGYLPPLCVDTCPPGRYGINCTSDCIGNCLDGKCDHAYGYCDKCPEGKTGTRCLDDCPSGKYGMDCAEGCPPSCLNGLCHPITGQCEACPEGFKGISCNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TBY8</accession>
    <name>A0A433TBY8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_013117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000470">
        <property type="protein sequence ID" value="RUS79107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TBY8"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS79107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="153" mass="17689" checksum="5E2E3FCBED7C0FDC" modified="2019-05-08" version="1" fragment="single">DQCVSYSLFWRHRCGWSGCRDQCVSYSLFWRHRCGWSGCRDQCVSYSLFWRHRCGWSGCRDQSVSNPLFWLHRGGWCGDQSVSNPLFWLHRGGWCGDESVSNPLFWLHRGGWCGDQSVSNPLFWLHRGGWCGDQSVSNPLIQANALRSAYCAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TFW2</accession>
    <name>A0A433TFW2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_011755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000389">
        <property type="protein sequence ID" value="RUS80477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TFW2"/>
    <dbReference type="OrthoDB" id="10648964at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS80477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="155" mass="18430" checksum="7526C2740E1FEC37" modified="2019-05-08" version="1">MPKSAAEKMREYRARMSNEKRQEMCNKNREQQKASRSKWSEDRRQCESENAKERKKKSRTRMKQTNQNVPLTPLTASCSTPFRTNQSLSKAGTKLHKLYQKVPERRQPLLRNCLTHFYHMLNLKPTVTDLNLTKSFNNFTKVTQFPDSYQEERTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433THF9</accession>
    <name>A0A433THF9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_011198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000359">
        <property type="protein sequence ID" value="RUS81032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433THF9"/>
    <dbReference type="STRING" id="188477.A0A433THF9"/>
    <dbReference type="OrthoDB" id="624345at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043454">
        <property type="entry name" value="NPH3/RPT2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027356">
        <property type="entry name" value="NPH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32370">
        <property type="entry name" value="OS12G0117600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03000">
        <property type="entry name" value="NPH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="13"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="634"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="533"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="643"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS81032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="732" mass="80342" checksum="8C320F7EEE71A233" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TIS1</accession>
    <name>A0A433TIS1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_010743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000335">
        <property type="protein sequence ID" value="RUS81487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TIS1"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS81487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="149" mass="16760" checksum="6675A3146BD8B618" modified="2019-05-08" version="1" fragment="single">KAQGKELSHQPQRRPNHPPQSPQSKRRDGTAKHKNVIPKQKLSRQDLALSFSSQQTKALVSPVSPTSPTSPQSPRGCRARPMSPLTVPGSPAPHHQKLSPQSPDGSVPGKQKQLQQQQQEQQQQLQQQQHLQRQQQQQQEQLQQHSLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TJJ4</accession>
    <name>A0A433TJJ4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isopropylmalate dehydrogenase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_010553</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000324">
        <property type="protein sequence ID" value="RUS81691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TJJ4"/>
    <dbReference type="STRING" id="188477.A0A433TJJ4"/>
    <dbReference type="OrthoDB" id="6118555at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000051">
        <property type="entry name" value="Isocitrate dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF42">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS81691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="249" mass="27713" checksum="BD08301F58F305EE" modified="2019-05-08" version="1" fragment="single">RRELDLFANVVCVRSLPGFPTRHNNLDFIIIREQTEGEYSALEHESVPGVVECLKIVTEQNSMRIAKFAFDYAMRHNRKKVTAVHKANIMKLGDGLFMRCCEEVSKLYPKIKFETMIIDNCCMQLVSNPYQFDVMVMPNLYGNIVDNLAAGLVGGAGVVPGESYSSRVAVFEQGARHSFAEAVGKDIANPTATLLSSCNMLKHMNLEHHARLIEDTVLKVVKGGKIRTKDMGGYSSTSNFIAEVIHCLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TKR1</accession>
    <name>A0A433TKR1_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_010112</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000301">
        <property type="protein sequence ID" value="RUS82138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TKR1"/>
    <dbReference type="OrthoDB" id="10463982at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS82138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="332" mass="36213" checksum="C31B018D079214CC" modified="2019-05-08" version="1">MPDESVYVAIAIACVVALLLLAIMVIYCVKRQQDKMHERIIRERRLREERQRRNFMRAQMVHPPSYEASRGRDQIICPVNRDIPWSPPPEYKEVATPIPGLRHNQVVGIGGAPDLFNGAAEYNEIPSVSRNVAPAYTYMPPGVSAQANNAVAISTNNNSSNINSNNNRNMVGSRTNASTRRSDNAIQVQVSPRAAHSLPDVVTSTTGSNNSIGANNRAQRSTGQNVHHPQSLHSSQGGNVHTMANSNTNNDRSNVVSTNRTNTESNRFRTAGTQPSSTYNSHSANAPGMSDSGNSYNEAVRSPAANQETASSSMSQRAKSQPQSQFQDLSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TLD9</accession>
    <name>A0A433TLD9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_009898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000290">
        <property type="protein sequence ID" value="RUS82345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TLD9"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS82345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="110" mass="12546" checksum="3ECE48B8F70DE1AE" modified="2019-05-08" version="1">MHYFSPKRAENVGKYDFLCLWLAALESAGLCWEHSLGIKSIEYVKLPYVILGPILEIDMLLKLDIKKSTLPPLIPRDKTLPVKSIRKTQLPPYVSLSDVWARYNLSQGVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TMY0</accession>
    <name>A0A433TMY0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_009280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000264">
        <property type="protein sequence ID" value="RUS82943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TMY0"/>
    <dbReference type="STRING" id="188477.A0A433TMY0"/>
    <dbReference type="OrthoDB" id="6156841at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS82943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="172" mass="19249" checksum="0A1E7F9796A2D8DA" modified="2019-05-08" version="1" fragment="single">MERRMFSLVLDWAKNNLNDLKPKMDRLIEQVNVLYLDSDNTLRDCAQVEDLVLSSDDEVVQDYQKMARRRSNGTKKDGGKSRMSVKSHGAQPFHKFSLNPEEALSVAEREWSIIAIHKTSDKAYLAIAMLDGHLMAISVHVRPPVIAPCTWGNVALDSATDRHSTNGNAKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TPQ6</accession>
    <name>A0A433TPQ6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Senescence domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_008636</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000238">
        <property type="protein sequence ID" value="RUS83582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TPQ6"/>
    <dbReference type="STRING" id="188477.A0A433TPQ6"/>
    <dbReference type="OrthoDB" id="20821at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009686">
        <property type="entry name" value="Senescence/spartin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045036">
        <property type="entry name" value="Spartin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21068">
        <property type="entry name" value="SPARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21068:SF43">
        <property type="entry name" value="SPARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06911">
        <property type="entry name" value="Senescence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Senescence" evidence="3">
        <location>
            <begin position="225"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS83582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="716" mass="79049" checksum="FE5CFFB0C2002D75" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TQF2</accession>
    <name>A0A433TQF2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">26S proteasome non-ATPase regulatory subunit 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">26S proteasome regulatory subunit RPN9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">26S proteasome regulatory subunit S11</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">26S proteasome regulatory subunit p40.5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_008445</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD13, a base containing 6 ATPases and few additional components.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the proteasome subunit S11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000230">
        <property type="protein sequence ID" value="RUS83787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TQF2"/>
    <dbReference type="STRING" id="188477.A0A433TQF2"/>
    <dbReference type="OrthoDB" id="1093at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054179">
        <property type="entry name" value="PSD13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035298">
        <property type="entry name" value="PSMD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22037">
        <property type="entry name" value="PSD13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="176"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS83787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="378" mass="43276" checksum="2C2A4C6CD454A878" modified="2019-05-08" version="1">MPKDVAGYLSEQQRKSAGDIATEWTTIDELYNKKLWHQLTLKLLQFCKNPIFAKGDGLLRLYENFLSDFEHRINPLSLAELSVFIVRQITDPKSALEFLEKMKDKVKASEEAKVLCMTLMGIIHLRNREFPPVKALIEESEKILNDIDGVSPVHGRFYELTSNYHKLMGNHAQYYQEALRFLGCTDLKDMPSGEQAERAFNIGLAAIIGDRVYNFGELLAHEILASLQNTNNAWLVELLYAFNSGNIDKFNALKDKWSAQPDLQANETVMRNKINLLCLMEMTFQRPATDRQLTFDNIAETARIPKDDVELLVMKALSLGLVRGSIDEIDQKCHMTWVQPRVLDRQQIASMQKRLDVLGNDIGHMERLLETHAHDILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TQI9</accession>
    <name>A0A433TQI9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_008408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000228">
        <property type="protein sequence ID" value="RUS83827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TQI9"/>
    <dbReference type="OrthoDB" id="6159119at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019319996" description="CUB domain-containing protein" evidence="2">
        <location>
            <begin position="35"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS83827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="40107" checksum="B1D70D94EA66381C" modified="2019-05-08" version="1">MASDEATTQVLPKLARFVFTLLWLKSVQLPTISCETVYFDKYGHCQRSWKPFDLDDDVYTLKSTGGNDAYNSMKCSMTFRAPSEYGICLTFKDVKITRCDVTIEIHNSKSDGNTEPAWYGHCQRSWKPFDLDDDVYTLKSTGGNDAYNSMKCSMTFRAPSEYGICLTFKDVKITRCDVTIEIHNSKSDGNTEPAWRTLSCYEDVPSPMCTSNRYVTVTVSKTRFSHYDGYEFEIEVEKNHAIGDWLPRQQEDTWGLTSPNILGNSLTSSSELDRGRTQDNGARDLTPNRGSAQPDMAPPVDEIYRPNEVTPVLAPDHQSSQDLPPPYVLPPPYEEEYSTSSAPPLHQENSGTSPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TQL1</accession>
    <name>A0A433TQL1_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha-carbonic anhydrase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_008316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000225">
        <property type="protein sequence ID" value="RUS83902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TQL1"/>
    <dbReference type="STRING" id="188477.A0A433TQL1"/>
    <dbReference type="OrthoDB" id="429145at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00326">
        <property type="entry name" value="alpha_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF124">
        <property type="entry name" value="CARBONIC ANHYDRASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS83902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="152" mass="16339" checksum="58D18D54CB97C761" modified="2019-05-08" version="1" fragment="single">MELHIVHYNTKYASLGEALDKADGLAVLGFMFEVSTENNSAYAGLVSSLAEIQASGASTSLTANVGSMIGDTADFYRYQGSLTTPNCAESVTWTVFKNTIPISQQQLAAFRSVLDSNGAAMVNNYRPVQPLAGRTVEASFSPNIKWGYLNNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TRA8</accession>
    <name>A0A433TRA8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_008238</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000221">
        <property type="protein sequence ID" value="RUS84016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TRA8"/>
    <dbReference type="STRING" id="188477.A0A433TRA8"/>
    <dbReference type="OrthoDB" id="5792673at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046974">
        <property type="term" value="F:histone H3K9 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070828">
        <property type="term" value="P:heterochromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01395">
        <property type="entry name" value="HMT_MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10517">
        <property type="entry name" value="SET_SETDB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21181">
        <property type="entry name" value="Tudor_SETDB1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.890.10">
        <property type="entry name" value="Methyl-cpg-binding Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001739">
        <property type="entry name" value="Methyl_CpG_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047232">
        <property type="entry name" value="SETDB1/2-like_MBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051516">
        <property type="entry name" value="SETDB_methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041292">
        <property type="entry name" value="Tudor_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46024">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE EGGLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46024:SF1">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE EGGLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01429">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05033">
        <property type="entry name" value="Pre-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18358">
        <property type="entry name" value="Tudor_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00391">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00468">
        <property type="entry name" value="PreSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50982">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50867">
        <property type="entry name" value="PRE_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MBD" evidence="13">
        <location>
            <begin position="141"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-SET" evidence="12">
        <location>
            <begin position="271"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="11">
        <location>
            <begin position="344"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="432"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS84016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="541" mass="62005" checksum="76A43AED36226D26" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TTL0</accession>
    <name>A0A433TTL0_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidoglycan-recognition protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EGW08_007361</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">EC2010</strain>
            <tissue evidence="11">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000190">
        <property type="protein sequence ID" value="RUS84892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TTL0"/>
    <dbReference type="STRING" id="188477.A0A433TTL0"/>
    <dbReference type="OrthoDB" id="10001926at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042834">
        <property type="term" value="F:peptidoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.80.10:FF:000001">
        <property type="entry name" value="Peptidoglycan recognition protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="entry name" value="Peptidoglycan recognition protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017331">
        <property type="entry name" value="Peptidoglycan_recognition"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015510">
        <property type="entry name" value="PGRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006619">
        <property type="entry name" value="PGRP_domain_met/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022">
        <property type="entry name" value="PEPTIDOGLYCAN RECOGNITION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022:SF41">
        <property type="entry name" value="PEPTIDOGLYCAN-RECOGNITION PROTEIN LC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037945">
        <property type="entry name" value="PGRPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00701">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="N-acetylmuramoyl-L-alanine amidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0391">Immunity</keyword>
    <keyword evidence="2 6" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019215765" description="Peptidoglycan-recognition protein" evidence="8">
        <location>
            <begin position="25"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidoglycan recognition protein family" evidence="10">
        <location>
            <begin position="36"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="9">
        <location>
            <begin position="48"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="35"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="74"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR037945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037945-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RUS84892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="199" mass="21691" checksum="0CC22B932DFFB6E2" modified="2019-05-08" version="1">MANKMFTPIWVCGLCLSLSVLVCAAPAKEKRAVSCPYIVPRSGWGARAPKSVTYLTNQPVQYAFIHHSESPADCMTRERCAAAVRSFQNYHMDTRGWSDVGYSFLIGGEGTVFEGRGWDRVGAHTGGYNSVGLGFCFIGNFGSQSPTAVQLDAAKQLITCGVSKGKIRSDYTVRGHRDMGSTSCPGDTLYNIIRGWSHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TTV0</accession>
    <name>A0A433TTV0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_007240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000186">
        <property type="protein sequence ID" value="RUS84995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TTV0"/>
    <dbReference type="STRING" id="188477.A0A433TTV0"/>
    <dbReference type="OrthoDB" id="8963064at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS84995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="240" mass="26087" checksum="CE81D6276DB30FFC" modified="2019-05-08" version="1">MNVNWIANARTKHTEGHIWSIQSPAFSLQHSVFSIQSSAFSIQHSVFSIQSSAAFGLQPSVFSIQPSAFSLQHSVFSLQSSAAFGLQHSVFSIQHSAFSIQSSAFSLQHSAFSSIWSSAFSLQHSAFSIQPLAFSLQHLVFSIQPSAAFGLQHSVFSIQHSAFRIQSSAFSLQQHLVFSIQSSAFSLQHSAFNIQPSAAFGLQHSVSSIQSSAFSLQHSAFNIQPSAAFGLQHSVFSTQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TUJ9</accession>
    <name>A0A433TUJ9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_006996</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000177">
        <property type="protein sequence ID" value="RUS85235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TUJ9"/>
    <dbReference type="STRING" id="188477.A0A433TUJ9"/>
    <dbReference type="OrthoDB" id="432447at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000157">
        <property type="entry name" value="Protein-tyrosine phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057023">
        <property type="entry name" value="PTP-SAK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF1">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22784">
        <property type="entry name" value="PTP-SAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="24"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS85235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="211" mass="24173" checksum="9A86B71D1A5A9FC8" modified="2019-05-08" version="1">MRHVGKELRIVRVPVRDYTPPTMEQVEQFIQEVLHNKARGQATCVHCAHGLGRTGTMLACYFVSAHGHDPEMAVDKTRKLRPGSIETSDQEELRSELVRRRRGKLRNGVLLLHDNAPAHRARQAVETADQCGYEMLPHPPYSPDLAPSDFCLFPNLKKSIKGRRFEDIEDAISAVEEWFQAQNDTFYSQGLLKVKDRWQKCVTMQGDYVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TVZ8</accession>
    <name>A0A433TVZ8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_006564</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000162">
        <property type="protein sequence ID" value="RUS85688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TVZ8"/>
    <dbReference type="STRING" id="188477.A0A433TVZ8"/>
    <dbReference type="OrthoDB" id="5984265at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF583">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS85688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="217" mass="24677" checksum="6D73A8FF0B0C1519" modified="2019-05-08" version="1" fragment="single">MLQEGSDEKLCDDFLKEIQLMKRVGYHRNVATMLGCCTMREPMCLLVEHLARGDLHNFMRKCRVRSAQVSRPQTQTYVNESADVINPMDLVKFALDIAKGMTFLSSKGFVHRDLAARNVLVARDKTCKIGDFGLARFIYNDAVYVNRKGGRLPVKWMSVEAIFDQSFSSASDVWSFGILLFELVTLGGVPYPTVPTRDLLRRLQAGYRMPRPDSCRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TXL7</accession>
    <name>A0A433TXL7_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fibrillar collagen NC1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_005926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000142">
        <property type="protein sequence ID" value="RUS86341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TXL7"/>
    <dbReference type="STRING" id="188477.A0A433TXL7"/>
    <dbReference type="OrthoDB" id="8939548at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1082">
        <property type="entry name" value="COLLAGEN TRIPLE HELIX REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="475"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="549"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="577"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="627"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="666"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="681"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS86341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="751" mass="77611" checksum="77B7D340662DE968" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433TZE8</accession>
    <name>A0A433TZE8_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_005284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000123">
        <property type="protein sequence ID" value="RUS86959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433TZE8"/>
    <dbReference type="OrthoDB" id="24526at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS86959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="105" mass="11593" checksum="17A7A3B8E28B03C1" modified="2019-05-08" version="1">MTPLVARNIPPLVARNILPLVARNILPLVARNIPPLVARNILPLVAGNIQLLVARHILPLVARNILPLVARNILPLVARNILPLVARNILPLVARNIIRLFARHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U060</accession>
    <name>A0A433U060_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">General transcription factor IIH subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_005047</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Part of TBP-based Pol II pre-initiation complex (PIC), in which Pol II core assembles with general transcription factors and other specific initiation factors including GTF2E1, GTF2E2, GTF2F1, GTF2F2, TCEA1, ERCC2, ERCC3, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2A1, GTF2A2, GTF2B and TBP; this large multi-subunit PIC complex mediates DNA unwinding and targets Pol II core to the transcription start site where the first phosphodiester bond forms.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TFB2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000117">
        <property type="protein sequence ID" value="RUS87207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U060"/>
    <dbReference type="STRING" id="188477.A0A433U060"/>
    <dbReference type="OrthoDB" id="364513at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2610:FF:000001">
        <property type="entry name" value="General transcription factor IIH subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040662">
        <property type="entry name" value="Tfb2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004598">
        <property type="entry name" value="TFIIH_p52/Tfb2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00625">
        <property type="entry name" value="tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152">
        <property type="entry name" value="TFIIH, POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03849">
        <property type="entry name" value="Tfb2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18307">
        <property type="entry name" value="Tfb2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor Tfb2 C-terminal" evidence="11">
        <location>
            <begin position="363"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00064576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS87207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="435" mass="49499" checksum="8498264FC3A76E0B" modified="2019-05-08" version="1" fragment="single">KLVCKDLHSYLRSLPPSVLDNLYCHPATCLAVYRDLPVLAQHYVMRILFVEQAVAQAVVKQWSTTSSEEQLEAAAALMELRVWYEQSLPGGMPGWLLNPIFRKNLSTSLLGGGTPWLGNKNLTPDKYAKDVPFLDKYALERWECVLHFMVGSNEGSDGVNKDITDILLHSRLMRLEGEPSITAEGFQFLLMDTSSQVWFFLLQYLDTVQTRGMDLVECLTFLFQLSFSTLGKDYSAEDMNENQLRFLQHLREFGLVYQRKRKSHRYYPTRLAINIVSGVSKASVASFSSASLVLLASLVSPLSPVALIFLLFPNLAVANLTRASARAAMSRGITAEQILHFLVSHAHPEMMKNTPILPATISDQIKLWELERDRIRFTDGVMYNQFLSQADFELLRNYAKDIDVLVWEMPEKRVIIVTKAGHDDVKKFWKRQRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U144</accession>
    <name>A0A433U144_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein-tyrosine-phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EGW08_004675</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">EC2010</strain>
            <tissue evidence="4">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000107">
        <property type="protein sequence ID" value="RUS87569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U144"/>
    <dbReference type="STRING" id="188477.A0A433U144"/>
    <dbReference type="OrthoDB" id="6272991at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF531">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE LAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="149"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RUS87569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="35154" checksum="F61D85A2EFFB498D" modified="2019-05-08" version="1">MDSTVHPITVGSDPQYRKLNRWTNILPYDHTRVKLKVVDGDEKCSDDYINANFLVGYRTSKDYIATQGPLTATIPDFWRMVWEQESSVLVMLSAFQEVDPVSLNIFISHMTGYTLIYQHITPKTYSDYRYVKHFFFKSWTDHKADISPSDLINFVNTVRDEAESHPPGPIVVHCSAGVGRTGTFIAVDYFCRYIKELSKKSKLSKITDVMGSLRGSWVKRKSVLWEDSPIDVYGRIIALRDCRRYMVQTKSQYAFIYDTVMELIRRGARGDDLSESGCDTESCLSEPLPAAGTSGTSDAVYDDVDVLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U1R0</accession>
    <name>A0A433U1R0_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EGW08_004515</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">EC2010</strain>
            <tissue evidence="7">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000102">
        <property type="protein sequence ID" value="RUS87769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="188477.A0A433U1R0"/>
    <dbReference type="OrthoDB" id="6252103at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001417">
        <property type="entry name" value="WD repeat domain 90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055441">
        <property type="entry name" value="Beta-prop_WDR90_POC16_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007714">
        <property type="entry name" value="CFA20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050630">
        <property type="entry name" value="WD_repeat_EMAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720:SF24">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720">
        <property type="entry name" value="WD-40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23393">
        <property type="entry name" value="Beta-prop_WDR90_POC16_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05018">
        <property type="entry name" value="CFA20_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CFA20" evidence="5">
        <location>
            <begin position="2"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="CFA20" evidence="5">
        <location>
            <begin position="143"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="719"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="WDR90/POC16 second beta-propeller" evidence="6">
        <location>
            <begin position="730"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="337"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RUS87769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1292" mass="142396" checksum="7BFAC9D7CEB27819" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U335</accession>
    <name>A0A433U335_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_004015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000089">
        <property type="protein sequence ID" value="RUS88249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U335"/>
    <dbReference type="STRING" id="188477.A0A433U335"/>
    <dbReference type="OrthoDB" id="6147954at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS88249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="104" mass="11824" checksum="FBB3882A96E9181F" modified="2019-05-08" version="1" fragment="single">EQQLTLYNKRRKSIVRPIIKAQEKLDRLGKKRSHKSGSEVTTPDSMKNTEGSMTTSSELVLPSPTKMRARKSRHRRNNSRGSIKDAGYPMFNTPPYGSTNDMTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U3G2</accession>
    <name>A0A433U3G2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EGW08_003904</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">EC2010</strain>
            <tissue evidence="8">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000086">
        <property type="protein sequence ID" value="RUS88333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U3G2"/>
    <dbReference type="STRING" id="188477.A0A433U3G2"/>
    <dbReference type="OrthoDB" id="5876240at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000604">
        <property type="entry name" value="Histone H4 transcription factor-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050688">
        <property type="entry name" value="Zinc_finger/UBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403:SF67">
        <property type="entry name" value="FI01116P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="481"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="509"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="547"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="576"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="604"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="632"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="336"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="872"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="876"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RUS88333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="1014" mass="110890" checksum="F96CC1949531295E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U3S8</accession>
    <name>A0A433U3S8_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_003801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000082">
        <property type="protein sequence ID" value="RUS88464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U3S8"/>
    <dbReference type="OrthoDB" id="1421278at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21513">
        <property type="entry name" value="MAJOR SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21513:SF19">
        <property type="entry name" value="MAJOR SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS88464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="39000" checksum="A041532DB07C2179" modified="2019-05-08" version="1">MGVSVDAGLDRPRLQSRKTLPNIKQADQMRQTDGKLHICFIDYSKAFDCVKHEELWETLKVNYSTQPALQAGYCVERPAHSFGLIFKLDTPLVLASQAVNSLQRHSRTQNDNLANNWELSSNSPGFLLSILVESVDVSKISPDAAGVLVSLNRHCMKYDAPTGHLNKSTLSSLQSLLVPLTFRVLFSSAAKVLIPTIPNTCTCEKLVDARDDDDDEGEDLGEGEHILHTGGPRDIGAIDKCEESCERSMERKQKPNLAEMAQRRKEREKERKQEGRTEEKKKEDEKKKKKKKKKKKKKKKKKKKKKKKKKKKKKMKKKKKKKKKKKKKKKKKKKKKKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U4I9</accession>
    <name>A0A433U4I9_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Beta-glucuronidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_003515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 79 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000075">
        <property type="protein sequence ID" value="RUS88700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U4I9"/>
    <dbReference type="OrthoDB" id="10066041at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005199">
        <property type="entry name" value="Glyco_hydro_79"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46145">
        <property type="entry name" value="HEPARANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46145:SF4">
        <property type="entry name" value="HEPARANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03662">
        <property type="entry name" value="Glyco_hydro_79n"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019333786" description="Beta-glucuronidase C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RUS88700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="538" mass="60562" checksum="B831C4CB62560022" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U4Z6</accession>
    <name>A0A433U4Z6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="4 13">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EGW08_003405</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">EC2010</strain>
            <tissue evidence="14">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Endoplasmic reticulum membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="4 13"/>
    <dbReference type="EMBL" id="RQTK01000072">
        <property type="protein sequence ID" value="RUS88860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U4Z6"/>
    <dbReference type="STRING" id="188477.A0A433U4Z6"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025770">
        <property type="entry name" value="PPMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51564">
        <property type="entry name" value="SAM_ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RUS88860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="287" mass="33285" checksum="A820580D231AEB08" modified="2019-05-08" version="1">MGMIRQARISLLSFCAGSSLILFPLVFYCLPFVSFLWRDLWLAVLLIHFVAVNGIFSAVYVHQKDSYRIVVRAGNLGIVFGLGFLLSLYSARWNLFGWYVMSLTFFHWSEYQITAMTNPKSLTLESFLLDHSTEYKIAAAASCVEFFLESLFLPNMKTLRYVSLIGAVMAVGGDFLRKLSMWTARTNFNHYIQHTKQDGHVLVSWGVYSLFRHPSYVGWYCWSVGTQVMLCNPICLVTYTVVSWKFFNERIYDEEICLLNFFGEDYLDYQRKVPTGIPFVYGYRQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U6M2</accession>
    <name>A0A433U6M2_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein FRG1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EGW08_002768</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">EC2010</strain>
            <tissue evidence="12">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Cajal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FRG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000055">
        <property type="protein sequence ID" value="RUS89471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U6M2"/>
    <dbReference type="STRING" id="188477.A0A433U6M2"/>
    <dbReference type="OrthoDB" id="5539371at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055120">
        <property type="term" value="C:striated muscle dense body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23338">
        <property type="entry name" value="beta-trefoil_FSCN_FRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000061">
        <property type="entry name" value="Protein FRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008999">
        <property type="entry name" value="Actin-crosslinking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013865">
        <property type="entry name" value="FAM32A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010414">
        <property type="entry name" value="FRG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928">
        <property type="entry name" value="FRG1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928:SF0">
        <property type="entry name" value="FSHD REGION GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08555">
        <property type="entry name" value="FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06229">
        <property type="entry name" value="FRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50405">
        <property type="entry name" value="Actin-crosslinking proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0517">Myogenesis</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RUS89471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="267" mass="29847" checksum="3DC1F904F2122A87" modified="2019-05-08" version="1">MADSYALVKGGKLNLKGHKIKKSKKHKSHKRKHDGSSASTPTDKQNDQEDVAKHGGWWEVKQFNDITANIAIEVGDRVYIAALDNGGLAIGEPRDEGDGPDPTEIFTAIKINDTKVAFKSGYGKYVTVEADGSLEAKVEAMGAREQFEPVFQDGKLALNGCNNCFLTCDEDGELACSARTAGEGEFLRLRSQAVRERDPMEDIPQEERGSVKDAEINYVKKFQSFQDRRLRVNEEDKTALKKAKKEGDFHEVMLDRRSKMKADRYCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U7Z4</accession>
    <name>A0A433U7Z4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Serine/threonine-protein kinase receptor</fullName>
            <ecNumber evidence="16">2.7.11.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">EGW08_002282</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">EC2010</strain>
            <tissue evidence="20">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[receptor-protein] + ATP = O-phospho-L-threonyl-[receptor-protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44880"/>
            <dbReference type="Rhea" id="RHEA-COMP:11024"/>
            <dbReference type="Rhea" id="RHEA-COMP:11025"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.30"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="16">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.30" evidence="16"/>
    <dbReference type="EMBL" id="RQTK01000044">
        <property type="protein sequence ID" value="RUS89930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U7Z4"/>
    <dbReference type="STRING" id="188477.A0A433U7Z4"/>
    <dbReference type="OrthoDB" id="69842at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004675">
        <property type="term" value="F:transmembrane receptor protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071363">
        <property type="term" value="P:cellular response to growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23532">
        <property type="entry name" value="TFP_LU_ECD_BMPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000018">
        <property type="entry name" value="Receptor protein serine/threonine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000055">
        <property type="entry name" value="Receptor protein serine/threonine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000472">
        <property type="entry name" value="Activin_recp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003605">
        <property type="entry name" value="GS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000333">
        <property type="entry name" value="TGFB_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255:SF68">
        <property type="entry name" value="RECEPTOR PROTEIN SERINE_THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01064">
        <property type="entry name" value="Activin_recp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08515">
        <property type="entry name" value="TGF_beta_GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00653">
        <property type="entry name" value="ACTIVIN2R"/>
    </dbReference>
    <dbReference type="SMART" id="SM00467">
        <property type="entry name" value="GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51256">
        <property type="entry name" value="GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 16" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7 17" id="KW-0732">Signal</keyword>
    <keyword evidence="4 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019474755" description="Serine/threonine-protein kinase receptor" evidence="17">
        <location>
            <begin position="29"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="GS" evidence="19">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="214"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RUS89930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="513" mass="58367" checksum="BEECD485C76CC636" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U8J3</accession>
    <name>A0A433U8J3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_002111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000039">
        <property type="protein sequence ID" value="RUS90144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U8J3"/>
    <dbReference type="STRING" id="188477.A0A433U8J3"/>
    <dbReference type="OrthoDB" id="10684316at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="691"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="778"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="424"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="449"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="476"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="637"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS90144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="817" mass="88103" checksum="9FF196873F83B712" modified="2019-05-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U954</accession>
    <name>A0A433U954_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_001916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000035">
        <property type="protein sequence ID" value="RUS90318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U954"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS90318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="173" mass="21140" checksum="8898C209C071A73C" modified="2019-05-08" version="1" fragment="single">MATHRERQVQHKQDLRGLATHRERQVQHQQDLRGLEETHRERQVQHQQDLRGLEETHRERQVQHQQDLRGLEETHRERQVQHQQDLRGLATHRERQVQHKQDLRGLATHRERQVQHQQDLRGLATHRERQVQHQQDLRGLATHRERQVQHQQDLRGLATHRERQVQHQQDLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U9X4</accession>
    <name>A0A433U9X4_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_001555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000027">
        <property type="protein sequence ID" value="RUS90655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U9X4"/>
    <dbReference type="STRING" id="188477.A0A433U9X4"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03044">
        <property type="entry name" value="GST_N_EF1Bgamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000233">
        <property type="entry name" value="Elongation factor 1-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050802">
        <property type="entry name" value="EF-GSTs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986:SF1">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS90655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="134" mass="14590" checksum="6C0627F10B813743" modified="2019-05-08" version="1">MASGTLYTYPNSFRANKALIAAQYSGAAVTVASNFKLGETNTSAEYLKKFPNGKVPAFEAKDGFCLSESNAIAYYVSNPQLHGENSKDAALVQQWISFSDNEILPAACTWVFPCLGITQFNKQVSLALKKMYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433U9Z6</accession>
    <name>A0A433U9Z6_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_001619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000028">
        <property type="protein sequence ID" value="RUS90622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433U9Z6"/>
    <dbReference type="STRING" id="188477.A0A433U9Z6"/>
    <dbReference type="OrthoDB" id="10059790at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF25">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="391"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS90622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="565" mass="65056" checksum="79182D8D01E6C411" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UBE3</accession>
    <name>A0A433UBE3_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">5'-nucleotidase</fullName>
            <ecNumber evidence="3 9">3.1.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EGW08_001093</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">EC2010</strain>
            <tissue evidence="10">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="EC" id="3.1.3.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the pyrimidine 5'-nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5" evidence="3 9"/>
    <dbReference type="EMBL" id="RQTK01000017">
        <property type="protein sequence ID" value="RUS91180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UBE3"/>
    <dbReference type="STRING" id="188477.A0A433UBE3"/>
    <dbReference type="OrthoDB" id="10014216at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.340:FF:000001">
        <property type="entry name" value="Cytosolic 5-nucleotidase 3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000032">
        <property type="entry name" value="Cytosolic 5-nucleotidase 3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.340">
        <property type="entry name" value="Pyrimidine 5'-nucleotidase (UMPH-1), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006434">
        <property type="entry name" value="Pyrimidine_nucleotidase_eu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01544">
        <property type="entry name" value="HAD-SF-IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13045">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13045:SF0">
        <property type="entry name" value="7-METHYLGUANOSINE PHOSPHATE-SPECIFIC 5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05822">
        <property type="entry name" value="UMPH-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01128">
        <property type="entry name" value="C1.4:_5'-Nucleotidase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RUS91180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="341" mass="39255" checksum="E0B26EE08EC51562" modified="2019-05-08" version="1" fragment="single">FLRSLYHHNTKPRVSNFHPAAYWSNKNVQALKIRTIIAAMLDSLKKLVPEFDRSNVRMRDPQLVEKAIRVMMKDAQHKLQVVADFDRTLSKYTENGQPCSTTHSVLEESKHMPEFYRVESLKLKELYLPIEFDHTKTIEEKIPKMIEWWHKGHALLTSCHLTQEDLTPIVTDSMARLRNGCKDFFNLLHSMDIPILIFSAGIGDVISETIKQQATFYPKNMKVVANFLQFDEMGKMVGFVGDEIIHTFNKNESAIHSSDYFYNIRHRENLLLMGDSLGDLRMAEGADQVECILKIGFLNFKVEENLDVYMKSYDVVILEDESLDVVNGIVKAILGKPTVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UC11</accession>
    <name>A0A433UC11_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine/threonine-protein kinase ULK4/RUNKEL HEAT repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EGW08_000837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">EC2010</strain>
            <tissue evidence="2">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000012">
        <property type="protein sequence ID" value="RUS91407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UC11"/>
    <dbReference type="STRING" id="188477.A0A433UC11"/>
    <dbReference type="OrthoDB" id="24822at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056981">
        <property type="entry name" value="HEAT_ULK4_RUNKEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045906">
        <property type="entry name" value="ULK4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46240">
        <property type="entry name" value="SER/THR PROTEIN KINASE ULK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46240:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ULK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23606">
        <property type="entry name" value="HEAT_ULK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine-protein kinase ULK4/RUNKEL HEAT repeats" evidence="1">
        <location>
            <begin position="5"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RUS91407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="308" mass="34154" checksum="C072F4DABBC2D05B" modified="2019-05-08" version="1">MDTRVDTSQLHGIIAEKLLPQFEPILLDLDPLPSYALKLTLALLEHDATFIRQMEQQGLVVVLFQVLMDHQTNPLGRVMQGVVAVVGCLVGHKETNMRELYDQGLIDHLTNLFFEVWTSVCEGEEGGRDVKTAVTMLLTLLDALNAVLRYVSEVVRRALQVKNKGGDGAQKEAEFGEQLLMMNKSLTDLTSLLTQLLCYEDTEIQDLAIKCLSLLVQLFGGENRDALAPENMDCYSKALKSTEAKKQKVLLRVIKRLLTTDARHLDTMKKQGVNLAKTIQSLADTASSHADIALTTVAAEILKMSGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A433UCC2</accession>
    <name>A0A433UCC2_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_000748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000010">
        <property type="protein sequence ID" value="RUS91527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A433UCC2"/>
    <dbReference type="OrthoDB" id="7489468at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS91527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="137" mass="15041" checksum="E490C3905B837BA0" modified="2019-05-08" version="1" fragment="single">CPSENCLLSPCPSENCLLSPCPSENCSHHVHQKTVLTMSTRKLFSPCPSENCLFSPCPSENCSHHVHQKTVCSHHVHQKTVLTMSIRKLSVLTMSIRKLSVLSPCPSENCLFSPCPSENCLFSPCSPENCLFGDQPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z4P3</accession>
    <name>A0A3S0Z4P3_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EGW08_021612</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">EC2010</strain>
            <tissue evidence="1">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001365">
        <property type="protein sequence ID" value="RUS70628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z4P3"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RUS70628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <sequence length="256" mass="34428" checksum="54ADF1FBD6F2A04E" modified="2019-04-10" version="1" fragment="single">RKWICDIRRKWLCNIRRKWLCNIRRKWICNIRRKWICDIRRKWLCNIRWKRFRDIWRKWLCDIRRKWICDVSSWWICDIRRKWICNIRWKWLCDIRRKRLCNIRRKWISHIWRKWISHIRRKWISHIWRKWISHIRRKWISHIRRKWICDVSSWWVCDIRRKWISHIRRKWLCNIRRKWLCDIRRKWFRDIWRKWIGDIWRKWIGDIRWKWLCYIWRKWICDIRRKWICDIRRKWICDIRRKWICDIRRKWFSHCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z8U5</accession>
    <name>A0A3S0Z8U5_ELYCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Peptidase M13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EGW08_018872</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">EC2010</strain>
            <tissue evidence="13">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01000944">
        <property type="protein sequence ID" value="RUS73370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z8U5"/>
    <dbReference type="STRING" id="188477.A0A3S0Z8U5"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018626808" description="Peptidase M13 N-terminal domain-containing protein" evidence="10">
        <location>
            <begin position="17"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="12">
        <location>
            <begin position="197"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="11">
        <location>
            <begin position="659"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RUS73370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000271974"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="874" mass="99824" checksum="2BE3ECEC74646154" modified="2019-04-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S0Z8V9</accession>
    <name>A0A3S0Z8V9_ELYCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EGW08_022741</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Elysia chlorotica</name>
        <name type="common">Eastern emerald elysia</name>
        <name type="synonym">Sea slug</name>
        <dbReference type="NCBI Taxonomy" id="188477"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Mollusca</taxon>
            <taxon>Gastropoda</taxon>
            <taxon>Heterobranchia</taxon>
            <taxon>Euthyneura</taxon>
            <taxon>Panpulmonata</taxon>
            <taxon>Sacoglossa</taxon>
            <taxon>Placobranchoidea</taxon>
            <taxon>Plakobranchidae</taxon>
            <taxon>Elysia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>A draft genome assembly of the solar-powered sea slug Elysia chlorotica.</title>
            <authorList>
                <person name="Cai H."/>
                <person name="Li Q."/>
                <person name="Fang X."/>
                <person name="Li J."/>
                <person name="Curtis N.E."/>
                <person name="Altenburger A."/>
                <person name="Shibata T."/>
                <person name="Feng M."/>
                <person name="Maeda T."/>
                <person name="Schwartz J.A."/>
                <person name="Shigenobu S."/>
                <person name="Lundholm N."/>
                <person name="Nishiyama T."/>
                <person name="Yang H."/>
                <person name="Hasebe M."/>
                <person name="Li S."/>
                <person name="Pierce S.K."/>
                <person name="Wang J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">EC2010</strain>
            <tissue evidence="3">Whole organism of an adult</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="RQTK01001664">
        <property type="protein sequence ID" value="RUS69494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S0Z8V9"/>
    <dbReference type="OrthoDB" id="6144776at2759"/>
    <dbReference type="Proteomes" id="UP000271974">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature typ